MCID: END035
MIFTS: 49

Endocrine Gland Cancer

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Gland Cancer

MalaCards integrated aliases for Endocrine Gland Cancer:

Name: Endocrine Gland Cancer 12 15
Malignant Neoplasm of Endocrine Gland 12 73
Endocrine Gland Neoplasms 44 73
Endocrine Neoplasm 12 55
Endocrine Cancer 29 55
Malignant Tumour of Endocrine Gland 12
Neoplasm of the Endocrine System 29
Neoplasm of Endocrine System 12
Carcinoma of Endocrine Gland 73
Neoplasm of Endocrine Gland 12
Malignant Endocrine Tumor 12
Endocrine Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:170
ICD10 33 C75.9
ICD9CM 35 194.9
MeSH 44 D004701
NCIt 50 C3010 C3575

Summaries for Endocrine Gland Cancer

Disease Ontology : 12 An organ system cancer located in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system.

MalaCards based summary : Endocrine Gland Cancer, also known as malignant neoplasm of endocrine gland, is related to non-functioning pancreatic endocrine tumor and islet cell tumor. An important gene associated with Endocrine Gland Cancer is RET (Ret Proto-Oncogene), and among its related pathways/superpathways are Signaling by GPCR and Glioma. The drugs Gemcitabine and Pancrelipase have been mentioned in the context of this disorder. Affiliated tissues include endocrine system, breast and pancreas, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Endocrine Gland Cancer

Diseases related to Endocrine Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 non-functioning pancreatic endocrine tumor 35.0 CHGA GAST SYP
2 islet cell tumor 33.2 CALCA CHGA GAST SST VIP
3 multiple endocrine neoplasia, type iia 32.9 CALCA RET SDHB
4 multiple endocrine neoplasia 32.9 CALCA CHGA RET SDHB
5 neuroendocrine tumor 32.8 CALCA CHGA GAST SST SYP
6 multiple endocrine neoplasia, type i 32.6 CHGA GAST GNAS RET SDHB SST
7 small cell cancer of the lung 32.5 CALCA CHGA GAST SST SYP VIP
8 pancreatic cancer 32.1 AREG GAST HRAS KDR KRAS SST
9 thyroid cancer 32.0 CALCA CHGA GNAS HRAS KDR KRAS
10 thyroiditis 31.4 CALCA RET TG
11 functioning pancreatic endocrine tumor 12.1
12 pancreatic neuroendocrine tumor 11.6
13 carney complex variant 11.3
14 esophageal neuroendocrine tumor 11.3 CHGA SYP
15 ureter small cell carcinoma 11.3 CHGA SYP
16 urinary bladder small cell neuroendocrine carcinoma 11.2 CHGA SYP
17 adenoma of the pancreas 11.2 CHGA SST SYP
18 gastrointestinal neuroendocrine tumor 11.2 CHGA SST SYP
19 autoimmune atrophic gastritis 11.2 CHGA GAST
20 testotoxicosis 11.2 CYP19A1 GNAS
21 pancreatoblastoma 11.2 CHGA SST SYP
22 mucoepidermoid thyroid carcinoma 11.2 CALCA TG
23 carcinoid tumors, intestinal 11.2 CHGA SST SYP
24 glucagonoma 11.2 CHGA SST VIP
25 pancreatic somatostatinoma 11.2 CALCA SST SYP
26 ectopic cushing syndrome 11.2 RET SST SYP
27 wdha syndrome 11.2 CALCA SST VIP
28 sigmoid neoplasm 11.2 HRAS KRAS
29 respiratory system benign neoplasm 11.2 CHGA KRAS SYP
30 ovarian large-cell neuroendocrine carcinoma 11.2 CHGA SYP
31 benign struma ovarii 11.2 HRAS RET TG
32 intestinal pseudo-obstruction 11.2 RET SST SYP
33 acute thyroiditis 11.2 CALCA CHGA TG
34 auditory system cancer 11.2 CHGA SYP
35 gastrointestinal neuroendocrine benign tumor 11.2 CHGA GAST SST
36 gastric neuroendocrine neoplasm 11.2 CHGA GAST SST
37 pulmonary blastoma 11.2 CHGA KRAS SYP
38 malignant glandular tumor of peripheral nerve sheath 11.1 SST SYP
39 malignant struma ovarii 11.1 HRAS RET TG
40 leprosy 2 11.1 CALCA VIP
41 villous adenoma 11.1 GNAS KRAS SST
42 hyperinsulinemic hypoglycemia, familial, 2 11.1 CHGA GAST SST
43 mccune-albright syndrome 11.1 CYP19A1 GNAS SST
44 gender identity disorder 11.1 AR CYP19A1 ESR1
45 nodular goiter 11.1 CALCA RET TG
46 acinar cell cystadenocarcinoma 11.1 CHGA SYP
47 breast papillary carcinoma 11.1 CHGA ESR1 RET SYP
48 diffuse pulmonary fibrosis 11.1 CALCA CHGA VIP
49 mucinous adenofibroma 11.1 ESR1 SYP
50 periampullary adenoma 11.1 HRAS KRAS SST

Graphical network of the top 20 diseases related to Endocrine Gland Cancer:



Diseases related to Endocrine Gland Cancer

Symptoms & Phenotypes for Endocrine Gland Cancer

GenomeRNAi Phenotypes related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.05 HRAS KRAS
2 Decreased viability GR00106-A-0 10.05 KRAS
3 Decreased viability GR00221-A-1 10.05 HRAS KRAS RET KDR ESR1
4 Decreased viability GR00221-A-2 10.05 HRAS KRAS RET KDR ESR1
5 Decreased viability GR00221-A-3 10.05 HRAS KDR
6 Decreased viability GR00221-A-4 10.05 RET KDR ESR1
7 Decreased viability GR00231-A 10.05 RET
8 Decreased viability GR00301-A 10.05 KRAS RET
9 Decreased viability GR00381-A-1 10.05 KRAS
10 Decreased viability GR00402-S-2 10.05 HRAS RET KDR ESR1 KRAS

MGI Mouse Phenotypes related to Endocrine Gland Cancer:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.44 TG VIP SST AREG ESR1 CHGA
2 endocrine/exocrine gland MP:0005379 10.39 TG VIP AREG ESR1 CHGA AR
3 cardiovascular system MP:0005385 10.35 VIP CYP19A1 AREG ESR1 CHGA AR
4 growth/size/body region MP:0005378 10.35 TG SST CYP19A1 AREG CHGA AR
5 behavior/neurological MP:0005386 10.32 SST SYP VIP AR CYP19A1 HRAS
6 mortality/aging MP:0010768 10.3 VIP SDHB SST AREG CHGA AR
7 immune system MP:0005387 10.27 VIP SST CYP19A1 AREG AR GAST
8 digestive/alimentary MP:0005381 10.26 SST AREG ESR1 AR CYP19A1 GAST
9 hematopoietic system MP:0005397 10.26 TG SDHB AR CYP19A1 AREG IAPP
10 nervous system MP:0003631 10.14 SST SYP TG AR CYP19A1 HRAS
11 integument MP:0010771 10.13 AR CYP19A1 AREG HRAS GNAS ESR1
12 normal MP:0002873 10.1 SYP VIP SST ESR1 AR CYP19A1
13 neoplasm MP:0002006 10.09 ESR1 AR GAST GNAS HRAS KRAS
14 no phenotypic analysis MP:0003012 10.02 SDHB SST ESR1 CHGA HRAS GNAS
15 renal/urinary system MP:0005367 9.91 SDHB CYP19A1 ESR1 CHGA AR HRAS
16 reproductive system MP:0005389 9.81 VIP AR CYP19A1 AREG CHGA ESR1
17 respiratory system MP:0005388 9.56 VIP HRAS GNAS ESR1 RET KRAS
18 skeleton MP:0005390 9.28 SST AR CYP19A1 HRAS IAPP GNAS

Drugs & Therapeutics for Endocrine Gland Cancer

Drugs for Endocrine Gland Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemcitabine Approved Phase 3 95058-81-4 60750
2
Pancrelipase Approved, Investigational Phase 3 53608-75-6
3 Antibodies Phase 3
4 Antibodies, Monoclonal Phase 3
5 Anti-Infective Agents Phase 3
6 Antimetabolites Phase 3
7 Antimetabolites, Antineoplastic Phase 3
8 Antiviral Agents Phase 3
9 Gastrointestinal Agents Phase 3
10 Immunoglobulins Phase 3
11 Immunosuppressive Agents Phase 3
12 pancreatin Phase 3
13
Denosumab Approved Phase 2 615258-40-7
14
Doxorubicin Approved, Investigational Phase 2,Phase 1 23214-92-8 31703
15
Etoposide Approved Phase 2 33419-42-0 36462
16
Mitotane Approved Phase 2 53-19-0 4211
17
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
18
Doxil Approved June 1999 Phase 2,Phase 1 31703
19 Bone Density Conservation Agents Phase 2
20 Calcium, Dietary Phase 2
21 Diphosphonates Phase 2
22 Anti-Bacterial Agents Phase 2,Phase 1
23 Antibiotics, Antitubercular Phase 2,Phase 1
24 Antimitotic Agents Phase 2
25 Antineoplastic Agents, Hormonal Phase 2
26 Antineoplastic Agents, Phytogenic Phase 2
27 Etoposide phosphate Phase 2
28 Krestin Phase 2
29 Topoisomerase Inhibitors Phase 2,Phase 1
30 Liver Extracts Phase 1
31
Epinephrine Approved, Vet_approved 51-43-4 5816
32
Racepinephrine Approved 329-65-7 838
33 Hormones Not Applicable
34 Epinephryl borate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas Terminated NCT01231347 Phase 3 AMG 479;Placebo;AMG 479;gemcitabine
2 Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Completed NCT00896454 Phase 2 denosumab
3 Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer Completed NCT00071058 Phase 2 XR9576 (Tariquidar)
4 Prospective Study Assessing Thyroidectomy Using Robot Active, not recruiting NCT02839655 Phase 2
5 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
6 Genetic Evaluation of Families With Endocrine Cancers Completed NCT01794676
7 Feasibility of Activity Monitoring in Patients With Cancer: Physical Activity Monitoring in Cancer Patients (PAMCaP) Completed NCT02583815
8 B-Receptor Signaling in Cardiomyopathy Completed NCT01135849
9 Pilot for The Breast Cancer Endocrine Therapy Adherence (BETA) Trial Completed NCT02256670 Not Applicable
10 Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms Recruiting NCT01005654

Search NIH Clinical Center for Endocrine Gland Cancer

Cochrane evidence based reviews: endocrine gland neoplasms

Genetic Tests for Endocrine Gland Cancer

Genetic tests related to Endocrine Gland Cancer:

# Genetic test Affiliating Genes
1 Neoplasm of the Endocrine System 29
2 Endocrine Cancer 29

Anatomical Context for Endocrine Gland Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Gland Cancer:

19
Endocrine System

MalaCards organs/tissues related to Endocrine Gland Cancer:

41
Breast, Pancreas, Liver, Bone

Publications for Endocrine Gland Cancer

Articles related to Endocrine Gland Cancer:

# Title Authors Year
1
Endocrine gland cancer. ( 8001005 )
1995

Variations for Endocrine Gland Cancer

Expression for Endocrine Gland Cancer

Search GEO for disease gene expression data for Endocrine Gland Cancer.

Pathways for Endocrine Gland Cancer

Pathways related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 AR CALCA ESR1 GAST GCG GNAS
2
Show member pathways
12.64 ESR1 GNAS HRAS KDR KRAS
3
Show member pathways
12.59 AR AREG HRAS KRAS MLH1 RET
4 12.42 AR ESR1 GNAS HRAS KRAS MLH1
5
Show member pathways
12.29 CALCA GCG GNAS IAPP
6
Show member pathways
12.27 ESR1 HRAS KDR KRAS
7 12.16 ESR1 HRAS KDR KRAS
8
Show member pathways
12.06 AREG HRAS KDR KRAS
9 11.95 AR CYP19A1 ESR1 KRAS
10 11.72 GNAS HRAS KRAS
11 11.56 HRAS KRAS RET
12 11.52 CALCA GCG GNAS IAPP VIP
13 11.5 GNAS HRAS KRAS
14
Show member pathways
11.48 HRAS KDR KRAS RET
15
Show member pathways
11.33 AR ESR1 GCG
16 11.31 AR CALCA CYP19A1
17 11.23 HRAS KDR KRAS
18 10.86 ESR1 HRAS KRAS
19 10.72 HRAS KRAS
20 10.61 ESR1 HRAS KRAS RET
21 10.38 GAST VIP
22 10.01 CYP19A1 ESR1

GO Terms for Endocrine Gland Cancer

Cellular components related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AREG CALCA CHGA GAST GCG IAPP
2 extracellular region GO:0005576 9.32 CALCA CHGA GAST GCG GNAS IAPP

Biological processes related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.93 AR AREG HRAS KDR KRAS VIP
2 cell-cell signaling GO:0007267 9.89 AR AREG CALCA IAPP SST
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.86 GCG HRAS KDR RET
4 epidermal growth factor receptor signaling pathway GO:0007173 9.72 AREG HRAS KRAS
5 negative regulation of bone resorption GO:0045779 9.57 CALCA IAPP
6 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.56 CALCA GCG GNAS VIP
7 response to isolation stress GO:0035900 9.54 HRAS KRAS
8 regulation of long-term neuronal synaptic plasticity GO:0048169 9.54 HRAS KRAS SYP
9 amylin receptor signaling pathway GO:0097647 9.52 CALCA IAPP
10 prostate gland growth GO:0060736 9.51 AR CYP19A1
11 mammary gland alveolus development GO:0060749 9.5 AR AREG ESR1
12 epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 9.48 AREG ESR1
13 positive regulation of MAPK cascade GO:0043410 9.35 AR HRAS IAPP KDR RET
14 positive regulation of cAMP metabolic process GO:0030816 9.33 CALCA CHGA IAPP
15 regulation of signaling receptor activity GO:0010469 9.23 AREG CALCA GAST GCG IAPP SST
16 signal transduction GO:0007165 10.1 AR ESR1 GAST GCG GNAS HRAS
17 G-protein coupled receptor signaling pathway GO:0007186 10.03 AREG CALCA GAST GCG GNAS IAPP

Molecular functions related to Endocrine Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 CALCA GAST GCG IAPP SST TG

Sources for Endocrine Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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