MCID: END036
MIFTS: 24

Endocrine Organ Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases
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Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0060089

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology: 11 An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary: Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is MIR483 (MicroRNA 483), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Sudden infant death syndrome (SIDS) susceptibility pathways. Affiliated tissues include endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body, and related phenotypes are neoplasm and no phenotypic analysis

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 32.7 REN POMC MIR483 MEN1
2 pheochromocytoma 32.4 SST SDHD SDHB RET REN PRL
3 benign exocrine pancreas neoplasm 11.3
4 pineocytoma 11.3
5 bronchial adenomas/carcinoids childhood 10.5 SST POMC
6 chiasmal syndrome 10.5 SST PRL POMC
7 sporadic pheochromocytoma/secreting paraganglioma 10.5 SDHD SDHB RET
8 prolactin producing pituitary tumor 10.5 PRL POMC MEN1
9 parathyroid transitional clear cell adenoma 10.5 PTH MEN1
10 acidophil adenoma 10.5 SST PRL POMC
11 nodular goiter 10.5 RET PTH MIR199A1
12 tsh producing pituitary tumor 10.5 SST PRL POMC
13 nonsyndromic paraganglioma 10.5 SDHB RET CHGA
14 pituitary-dependent cushing's disease 10.5 SST PRL POMC
15 carotid body cancer 10.5 SDHD SDHB CHGA
16 neural crest tumor 10.5 SDHD SDHB
17 peripartum cardiomyopathy 10.5 PRL MIR21 MIR199A1
18 goiter 10.5 SST RET PRL
19 cranial nerve palsy 10.5 SDHD SDHB PRL POMC
20 nelson syndrome 10.5 SST PRL POMC
21 hypocalciuric hypercalcemia, familial, type i 10.5 PTH MIR139 MEN1
22 hypocalciuric hypercalcemia, familial, type ii 10.5 PTH MIR139 MEN1
23 cerebral angioma 10.5 SDHD SDHB RET
24 thyroid dyshormonogenesis 2a 10.5 SST RET POMC
25 pituitary apoplexy 10.5 SST PRL POMC
26 miyoshi muscular dystrophy 1 10.5 MIR221 MIR210 MIR21
27 glioma 10.5 NGF MIR221 MIR210 MIR21
28 primary pigmented nodular adrenocortical disease 10.5 PRL POMC MIR483 MEN1
29 paragangliomas 4 10.5 SDHD SDHB
30 inappropriate adh syndrome 10.5 REN PRL POMC
31 pituitary infarct 10.5 SST PRL POMC MEN1
32 horner's syndrome 10.5 SDHD SDHB NGF
33 substernal goiter 10.5 RET PTH
34 hypoaldosteronism 10.5 REN POMC
35 non-functioning pancreatic endocrine tumor 10.5 SST MEN1 CHGA
36 steroid inherited metabolic disorder 10.5 REN PRL POMC
37 carcinoid syndrome 10.5 SST SDHD CHGA
38 gastric leiomyosarcoma 10.5 SDHD SDHB
39 pituitary adenoma 1, multiple types 10.5 SST PRL MEN1
40 endometriosis of ovary 10.5 MIR221 MIR199A1 MIR139
41 gastric gastrinoma 10.5 SST MEN1 CHGA
42 central nervous system benign neoplasm 10.5 POMC MIR21 MIR199A1 MIR139
43 functionless pituitary adenoma 10.5 SST POMC
44 hormone producing pituitary cancer 10.5 SST PRL POMC MEN1
45 ectopic cushing syndrome 10.5 SST PRL POMC CHGA
46 hyperpituitarism 10.5 SST PRL POMC MEN1
47 tuberculum sellae meningioma 10.5 PRL POMC
48 pancreatic cholera 10.5 SST MEN1 CHGA
49 lymph node disease 10.5 SDHD SDHB RET MIR483
50 gastrointestinal neuroendocrine benign tumor 10.5 SST MEN1 CHGA

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:



Diseases related to Endocrine Organ Benign Neoplasm

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.7 MEN1 MIR139 POMC PRL RET SDHB
2 no phenotypic analysis MP:0003012 9.61 CHGA MIR126 MIR199A1 MIR210 NGF POMC
3 mortality/aging MP:0010768 9.47 CHGA MEN1 MIR126 MIR139 MIR199A1 MIR210

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Endocrine Organ Benign Neoplasm

Genetic Tests for Endocrine Organ Benign Neoplasm

Anatomical Context for Endocrine Organ Benign Neoplasm

Organs/tissues related to Endocrine Organ Benign Neoplasm:

FMA: Endocrine Glands Which Secretes A Type Of Hormone Directly Into The Bloodstream To Regulate The Body

Publications for Endocrine Organ Benign Neoplasm

Variations for Endocrine Organ Benign Neoplasm

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 MIR221 MIR210 MIR21
2 11.13 SST RET NGF MIR210
3 10.92 MIR21 MIR199A1 MIR126
4
Show member pathways
10.34 SDHD SDHB

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.8 MIR221 MIR210 MIR21 MIR199A1 MIR183 MIR139
2 extracellular space GO:0005615 9.64 SST REN PTH PRL POMC NGF
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.46 SDHD SDHB

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.78 MIR210 MIR21 MIR199A1 MIR126
2 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.76 SDHD SDHB
3 miRNA-mediated gene silencing GO:0035195 9.7 MIR483 MIR221 MIR210 MIR21 MIR199A1 MIR183
4 hormone-mediated apoptotic signaling pathway GO:0008628 9.67 SST PTH
5 positive regulation of protein kinase B signaling GO:0051897 9.63 MIR126 MIR199A1 MIR21 MIR221 RET
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 MIR221 MIR210 MIR126
7 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.5 MIR483 MIR221 MIR199A1
8 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.4 MIR210 MIR21
9 negative regulation of interleukin-21 production GO:0032705 9.26 MIR221 MIR21
10 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.02 MIR483 MIR221 MIR210 MIR21 MIR126

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.86 SST PTH PRL POMC
2 ubiquinone binding GO:0048039 9.62 SDHD SDHB
3 mRNA 3'-UTR binding GO:0003730 9.56 MIR483 MIR210 MIR21 MIR199A1 MIR183 MIR139
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.46 SDHD SDHB
5 mRNA base-pairing translational repressor activity GO:1903231 9.28 MIR483 MIR221 MIR210 MIR21 MIR199A1 MIR183

Sources for Endocrine Organ Benign Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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