Endocrine Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: END036 MIFTS: 26	Endocrine Organ Benign Neoplasm Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060089

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Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and MicroRNAs in cancer. Affiliated tissues include endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body, pituitary and thyroid, and related phenotypes are homeostasis/metabolism and no phenotypic analysis

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Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal adenoma	32.6	REN POMC MIR483 MEN1
2	pheochromocytoma	32.1	TMEM127 SST SDHD SDHB SDHA RET
3	benign exocrine pancreas neoplasm	11.2
4	bronchial adenomas/carcinoids childhood	10.6	SST POMC
5	adenohypophysitis	10.6	PRL POMC
6	tuberculum sellae meningioma	10.6	PRL POMC
7	parathyroid transitional clear cell adenoma	10.6	PTH MEN1
8	sella turcica neoplasm	10.6	PRL POMC
9	clear cell adenoma	10.6	PTH MEN1
10	acute adrenal insufficiency	10.6	REN POMC
11	acidophil adenoma	10.6	SST PRL POMC
12	tsh producing pituitary tumor	10.6	SST PRL POMC
13	sporadic pheochromocytoma/secreting paraganglioma	10.6	SDHD SDHB RET
14	chiasmal syndrome	10.6	SST POMC
15	pituitary-dependent cushing's disease	10.6	SST PRL POMC
16	benign essential hypertension	10.6	REN PRL POMC
17	plethora of newborn	10.6	SDHD SDHB
18	nelson syndrome	10.6	SST PRL POMC
19	foster-kennedy syndrome	10.6	SDHD SDHA
20	neural crest tumor	10.5	SDHD SDHB SDHA
21	miyoshi muscular dystrophy 1	10.5	MIR221 MIR210 MIR21
22	nonsyndromic paraganglioma	10.5	SDHB RET CHGA
23	prolactin producing pituitary tumor	10.5	PRL POMC
24	steroid inherited metabolic disorder	10.5	REN PRL POMC
25	gastric leiomyosarcoma	10.5	SDHD SDHB SDHA
26	functionless pituitary adenoma	10.5	SST POMC
27	cranial nerve palsy	10.5	SDHD SDHB PRL POMC
28	hypoaldosteronism	10.5	REN POMC
29	paragangliomas 1	10.5	SDHD SDHB SDHA
30	peripartum cardiomyopathy	10.5	PRL MIR210 MIR21
31	colon neuroendocrine neoplasm	10.5	SST POMC CHGA
32	chromophobe adenoma	10.5	PRL POMC
33	pituitary adenoma 1, multiple types	10.5	SST PRL MEN1
34	gastrointestinal neuroendocrine benign tumor	10.5	SST MEN1 CHGA
35	sexual disorder	10.5	REN PRL POMC
36	non-functioning pancreatic endocrine tumor	10.5	SST MEN1 CHGA
37	carney triad	10.5	SDHD SDHB SDHA
38	pituitary infarct	10.5	SST PRL POMC MEN1
39	gastric gastrinoma	10.5	MEN1 CHGA
40	ampulla of vater benign neoplasm	10.5	SST CHGA
41	duodenal gastrinoma	10.5	SST MEN1 CHGA
42	lipomatosis	10.5	SDHB MIR483 MEN1
43	gastric neuroendocrine neoplasm	10.5	SST MEN1 CHGA
44	abducens nerve disease	10.5	PRL POMC
45	endocrine pancreas disease	10.5	SST MEN1 CHGA
46	hormone producing pituitary cancer	10.5	SST PRL POMC MEN1
47	multiple mucosal neuroma	10.5	RET MEN1
48	chondroma	10.5	SDHD SDHB SDHA
49	premenstrual tension	10.5	REN POMC
50	ectopic cushing syndrome	10.5	SST PRL POMC CHGA

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:

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Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.77	CHGA MEN1 NGF POMC PRL PTH
2	no phenotypic analysis	MP:0003012	9.17	CHGA NGF POMC RET SDHB SST

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Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

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Genetic Tests for Endocrine Organ Benign Neoplasm

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Anatomical Context for Endocrine Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

¹⁹

Endocrine Glands Which Secretes A Type Of Hormone Directly Into The Bloodstream To Regulate The Body

MalaCards organs/tissues related to Endocrine Organ Benign Neoplasm:

⁴⁰

Pituitary, Thyroid, Pancreas, Bone, Heart, Small Intestine, Kidney

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Publications for Endocrine Organ Benign Neoplasm

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Genes for Endocrine Organ Benign Neoplasm

Genes related to Endocrine Organ Benign Neoplasm (0 elite genes):

(show top 50) (show all 59)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR483	MicroRNA 483	RNA Gene	10.45	DISEASES inferred ¹⁵ ¹⁵
2	POMC	Proopiomelanocortin	Protein Coding	9.68	DISEASES inferred ¹⁵
3	MIR221	MicroRNA 221	RNA Gene	9.38	DISEASES inferred ¹⁵ ¹⁵
4	PRL	Prolactin	Protein Coding	9.37	DISEASES inferred ¹⁵
5	MIR21	MicroRNA 21	RNA Gene	9.36	DISEASES inferred ¹⁵ ¹⁵
6	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	9.3	DISEASES inferred ¹⁵
7	MIR139	MicroRNA 139	RNA Gene	9.26	DISEASES inferred ¹⁵ ¹⁵
8	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	9.26	DISEASES inferred ¹⁵
9	MIR210	MicroRNA 210	RNA Gene	9.22	DISEASES inferred ¹⁵ ¹⁵
10	PTH	Parathyroid Hormone	Protein Coding	9	DISEASES inferred ¹⁵
11	RET	Ret Proto-Oncogene	Protein Coding	8.94	DISEASES inferred ¹⁵
12	SST	Somatostatin	Protein Coding	8.86	DISEASES inferred ¹⁵
13	MEN1	Menin 1	Protein Coding	8.85	DISEASES inferred ¹⁵
14	REN	Renin	Protein Coding	8.83	DISEASES inferred ¹⁵
15	NGF	Nerve Growth Factor	Protein Coding	8.73	DISEASES inferred ¹⁵
16	MIR126	MicroRNA 126	RNA Gene	8.68	DISEASES inferred ¹⁵ ¹⁵
17	MIR93	MicroRNA 93	RNA Gene	8.64	DISEASES inferred ¹⁵ ¹⁵
18	CHGA	Chromogranin A	Protein Coding	8.48	DISEASES inferred ¹⁵
19	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	8.4	DISEASES inferred ¹⁵
20	TMEM127	Transmembrane Protein 127	Protein Coding	8.37	DISEASES inferred ¹⁵
21	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	8.33	DISEASES inferred ¹⁵
22	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	8.33	DISEASES inferred ¹⁵
23	MIR582	MicroRNA 582	RNA Gene	8.33	DISEASES inferred ¹⁵ ¹⁵
24	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	8.29	DISEASES inferred ¹⁵
25	SYP	Synaptophysin	Protein Coding	8.23	DISEASES inferred ¹⁵
26	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	8.23	DISEASES inferred ¹⁵
27	IGF1	Insulin Like Growth Factor 1	Protein Coding	8.19	DISEASES inferred ¹⁵
28	MIR191	MicroRNA 191	RNA Gene	8.12	DISEASES inferred ¹⁵ ¹⁵
29	NF1	Neurofibromin 1	Protein Coding	8.12	DISEASES inferred ¹⁵
30	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	8.11	DISEASES inferred ¹⁵
31	MIR181A1	MicroRNA 181a-1	RNA Gene	8.06	DISEASES inferred ¹⁵ ¹⁵
32	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	7.95	DISEASES inferred ¹⁵
33	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	7.88	DISEASES inferred ¹⁵
34	ADM	Adrenomedullin	Protein Coding	7.83	DISEASES inferred ¹⁵
35	CDC73	Cell Division Cycle 73	Protein Coding	7.78	DISEASES inferred ¹⁵
36	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	7.76	DISEASES inferred ¹⁵
37	CRH	Corticotropin Releasing Hormone	Protein Coding	7.75	DISEASES inferred ¹⁵
38	SSTR5	Somatostatin Receptor 5	Protein Coding	7.75	DISEASES inferred ¹⁵
39	TRH	Thyrotropin Releasing Hormone	Protein Coding	7.72	DISEASES inferred ¹⁵
40	FH	Fumarate Hydratase	Protein Coding	7.72	DISEASES inferred ¹⁵
41	H2AC18	H2A Clustered Histone 18	Protein Coding	7.72	DISEASES inferred ¹⁵ ¹⁵
42	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	7.71	DISEASES inferred ¹⁵
43	MIR142	MicroRNA 142	RNA Gene	7.71	DISEASES inferred ¹⁵ ¹⁵
44	ENO2	Enolase 2	Protein Coding	7.67	DISEASES inferred ¹⁵
45	SSTR2	Somatostatin Receptor 2	Protein Coding	7.66	DISEASES inferred ¹⁵
46	SERPINA3	Serpin Family A Member 3	Protein Coding	7.64	DISEASES inferred ¹⁵ ¹⁵
47	TP53	Tumor Protein P53	Protein Coding	7.61	DISEASES inferred ¹⁵
48	TG	Thyroglobulin	Protein Coding	7.61	DISEASES inferred ¹⁵
49	MIR335	MicroRNA 335	RNA Gene	7.58	DISEASES inferred ¹⁵ ¹⁵
50	GHRH	Growth Hormone Releasing Hormone	Protein Coding	7.57	DISEASES inferred ¹⁵

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Variations for Endocrine Organ Benign Neoplasm

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Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

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Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Citrate cycle (TCA cycle) ³⁶ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.51	SDHD SDHB SDHA
2	MicroRNAs in cancer ³⁶	11.51	MIR483 MIR221 MIR210 MIR21 MIR126
3	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	11.47	SST RET NGF MIR210
4	miRNAs involved in DNA damage response ¹	11.03	MIR93 MIR221 MIR210
5	EV release from cardiac cells and their functional effects ¹	10.21	PRL MIR126

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GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular vesicle	GO:1903561	9.46	MIR93 MIR221 MIR21 MIR126
2	extracellular space	GO:0005615	9.44	SST REN PTH PRL POMC NGF
3	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	9.13	SDHD SDHB SDHA

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	response to drug	GO:0042493	9.83	SST RET REN PTH
2	positive regulation of protein kinase B signaling	GO:0051897	9.78	RET MIR221 MIR21 MIR126
3	regulation of blood pressure	GO:0008217	9.69	REN POMC CHGA
4	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.61	MIR221 MIR210 MIR126
5	gene silencing by miRNA	GO:0035195	9.5	MIR93 MIR483 MIR221 MIR210 MIR21 MIR139
6	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.49	MIR210 MIR21
7	succinate metabolic process	GO:0006105	9.46	SDHB SDHA
8	miRNA mediated inhibition of translation	GO:0035278	9.46	MIR483 MIR221 MIR210 MIR21
9	tricarboxylic acid cycle	GO:0006099	9.43	SDHD SDHB SDHA
10	negative regulation of interleukin-21 production	GO:0032705	9.4	MIR221 MIR21
11	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.37	SDHD SDHA
12	hormone-mediated apoptotic signaling pathway	GO:0008628	9.32	SST PTH
13	negative regulation of cell proliferation	GO:0008285	9.17	TMEM127 SST NGF MIR93 MIR221 MIR21

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.62	MIR93 MIR21 MIR139 MIR126
2	electron transfer activity	GO:0009055	9.58	SDHD SDHB SDHA
3	ubiquinone binding	GO:0048039	9.37	SDHD SDHB
4	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.26	SDHB SDHA
5	hormone activity	GO:0005179	9.26	SST PTH PRL POMC
6	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.17	MIR93 MIR483 MIR221 MIR210 MIR21 MIR139
7	succinate dehydrogenase activity	GO:0000104	9.16	SDHD SDHA

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Sources for Endocrine Organ Benign Neoplasm

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