MCID: END036
MIFTS: 26

Endocrine Organ Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060089

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is MIR483 (MicroRNA 483), and among its related pathways/superpathways are Citrate cycle (TCA cycle) and MicroRNAs in cancer. Affiliated tissues include endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body, pituitary and thyroid, and related phenotypes are homeostasis/metabolism and no phenotypic analysis

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 32.6 REN POMC MIR483 MEN1
2 pheochromocytoma 32.1 TMEM127 SST SDHD SDHB SDHA RET
3 benign exocrine pancreas neoplasm 11.2
4 bronchial adenomas/carcinoids childhood 10.6 SST POMC
5 adenohypophysitis 10.6 PRL POMC
6 tuberculum sellae meningioma 10.6 PRL POMC
7 parathyroid transitional clear cell adenoma 10.6 PTH MEN1
8 sella turcica neoplasm 10.6 PRL POMC
9 clear cell adenoma 10.6 PTH MEN1
10 acute adrenal insufficiency 10.6 REN POMC
11 acidophil adenoma 10.6 SST PRL POMC
12 tsh producing pituitary tumor 10.6 SST PRL POMC
13 sporadic pheochromocytoma/secreting paraganglioma 10.6 SDHD SDHB RET
14 chiasmal syndrome 10.6 SST POMC
15 pituitary-dependent cushing's disease 10.6 SST PRL POMC
16 benign essential hypertension 10.6 REN PRL POMC
17 plethora of newborn 10.6 SDHD SDHB
18 nelson syndrome 10.6 SST PRL POMC
19 foster-kennedy syndrome 10.6 SDHD SDHA
20 neural crest tumor 10.5 SDHD SDHB SDHA
21 miyoshi muscular dystrophy 1 10.5 MIR221 MIR210 MIR21
22 nonsyndromic paraganglioma 10.5 SDHB RET CHGA
23 prolactin producing pituitary tumor 10.5 PRL POMC
24 steroid inherited metabolic disorder 10.5 REN PRL POMC
25 gastric leiomyosarcoma 10.5 SDHD SDHB SDHA
26 functionless pituitary adenoma 10.5 SST POMC
27 cranial nerve palsy 10.5 SDHD SDHB PRL POMC
28 hypoaldosteronism 10.5 REN POMC
29 paragangliomas 1 10.5 SDHD SDHB SDHA
30 peripartum cardiomyopathy 10.5 PRL MIR210 MIR21
31 colon neuroendocrine neoplasm 10.5 SST POMC CHGA
32 chromophobe adenoma 10.5 PRL POMC
33 pituitary adenoma 1, multiple types 10.5 SST PRL MEN1
34 gastrointestinal neuroendocrine benign tumor 10.5 SST MEN1 CHGA
35 sexual disorder 10.5 REN PRL POMC
36 non-functioning pancreatic endocrine tumor 10.5 SST MEN1 CHGA
37 carney triad 10.5 SDHD SDHB SDHA
38 pituitary infarct 10.5 SST PRL POMC MEN1
39 gastric gastrinoma 10.5 MEN1 CHGA
40 ampulla of vater benign neoplasm 10.5 SST CHGA
41 duodenal gastrinoma 10.5 SST MEN1 CHGA
42 lipomatosis 10.5 SDHB MIR483 MEN1
43 gastric neuroendocrine neoplasm 10.5 SST MEN1 CHGA
44 abducens nerve disease 10.5 PRL POMC
45 endocrine pancreas disease 10.5 SST MEN1 CHGA
46 hormone producing pituitary cancer 10.5 SST PRL POMC MEN1
47 multiple mucosal neuroma 10.5 RET MEN1
48 chondroma 10.5 SDHD SDHB SDHA
49 premenstrual tension 10.5 REN POMC
50 ectopic cushing syndrome 10.5 SST PRL POMC CHGA

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:



Diseases related to Endocrine Organ Benign Neoplasm

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.77 CHGA MEN1 NGF POMC PRL PTH
2 no phenotypic analysis MP:0003012 9.17 CHGA NGF POMC RET SDHB SST

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

Genetic Tests for Endocrine Organ Benign Neoplasm

Anatomical Context for Endocrine Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

19
Endocrine Glands Which Secretes A Type Of Hormone Directly Into The Bloodstream To Regulate The Body

MalaCards organs/tissues related to Endocrine Organ Benign Neoplasm:

40
Pituitary, Thyroid, Pancreas, Bone, Heart, Small Intestine, Kidney

Publications for Endocrine Organ Benign Neoplasm

Variations for Endocrine Organ Benign Neoplasm

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Pathways for Endocrine Organ Benign Neoplasm

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular vesicle GO:1903561 9.46 MIR93 MIR221 MIR21 MIR126
2 extracellular space GO:0005615 9.44 SST REN PTH PRL POMC NGF
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.13 SDHD SDHB SDHA

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.83 SST RET REN PTH
2 positive regulation of protein kinase B signaling GO:0051897 9.78 RET MIR221 MIR21 MIR126
3 regulation of blood pressure GO:0008217 9.69 REN POMC CHGA
4 positive regulation of blood vessel endothelial cell migration GO:0043536 9.61 MIR221 MIR210 MIR126
5 gene silencing by miRNA GO:0035195 9.5 MIR93 MIR483 MIR221 MIR210 MIR21 MIR139
6 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.49 MIR210 MIR21
7 succinate metabolic process GO:0006105 9.46 SDHB SDHA
8 miRNA mediated inhibition of translation GO:0035278 9.46 MIR483 MIR221 MIR210 MIR21
9 tricarboxylic acid cycle GO:0006099 9.43 SDHD SDHB SDHA
10 negative regulation of interleukin-21 production GO:0032705 9.4 MIR221 MIR21
11 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.37 SDHD SDHA
12 hormone-mediated apoptotic signaling pathway GO:0008628 9.32 SST PTH
13 negative regulation of cell proliferation GO:0008285 9.17 TMEM127 SST NGF MIR93 MIR221 MIR21

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.62 MIR93 MIR21 MIR139 MIR126
2 electron transfer activity GO:0009055 9.58 SDHD SDHB SDHA
3 ubiquinone binding GO:0048039 9.37 SDHD SDHB
4 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.26 SDHB SDHA
5 hormone activity GO:0005179 9.26 SST PTH PRL POMC
6 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR93 MIR483 MIR221 MIR210 MIR21 MIR139
7 succinate dehydrogenase activity GO:0000104 9.16 SDHD SDHA

Sources for Endocrine Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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