Endocrine Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060089

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Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and parathyroid transitional clear cell adenoma. An important gene associated with Endocrine Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Aldosterone synthesis and secretion. Affiliated tissues include endocrine gl, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

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Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal adenoma	30.8	CRH CYP11B1 CYP11B2 KCNJ5 MEN1 POMC
2	parathyroid transitional clear cell adenoma	10.9	MEN1 PTH
3	silent pituitary adenoma	10.9	AIP MEN1
4	null pituitary adenoma	10.9	AIP MEN1
5	bronchus adenoma	10.9	POMC SST
6	acute adrenal insufficiency	10.9	POMC REN
7	scleredema adultorum	10.9	POMC PTH
8	hypoaldosteronism	10.8	CYP11B2 POMC REN
9	pituitary apoplexy	10.8	AIP POMC PRL
10	galactorrhea	10.8	IGF1 PRL
11	pancreatic gastrinoma	10.8	MEN1 SST
12	tsh producing pituitary tumor	10.8	PRL SST
13	chiasmal syndrome	10.8	POMC PRL SST
14	mineral metabolism disease	10.7	POMC PTH REN
15	generalized resistance to thyroid hormone	10.7	PRL TRH
16	multiple endocrine neoplasia, type iv	10.7	AIP MEN1 PRL
17	adenohypophysitis	10.7	POMC PRL TRH
18	pancreatic somatostatinoma	10.7	MEN1 SST
19	steroid inherited metabolic disorder	10.7	CYP11B1 CYP11B2 POMC
20	carney complex variant	10.7	AIP MEN1 POMC
21	central nervous system organ benign neoplasm	10.7	IGF1 POMC PRL
22	inappropriate adh syndrome	10.7	POMC REN
23	adrenal rest tumor	10.7	CYP11B1 CYP11B2 POMC
24	postural hypotension	10.7	REN SST
25	growth hormone secreting pituitary adenoma	10.7	AIP PRL SST
26	acidophil adenoma	10.6	IGF1 POMC SST
27	pituitary hormone deficiency, combined, 2	10.6	IGF1 POMC PRL
28	hyperandrogenism	10.6	IGF1 POMC PRL
29	endocrine exophthalmos	10.6	POMC TG
30	acth-secreting pituitary adenoma	10.6	CRH POMC PRL
31	pseudohypoparathyroidism, type ia	10.6	IGF1 PRL TRH
32	adrenal cortical hypofunction	10.5	CRH POMC REN
33	pancreas disease	10.5	IGF1 POMC SST
34	mccune-albright syndrome	10.5	IGF1 PRL SST
35	fibrous dysplasia	10.5	IGF1 PRL SST
36	prolactin producing pituitary tumor	10.5	PRL SST
37	adrenocortical carcinoma, hereditary	10.5	CYP11B1 CYP11B2 POMC
38	apparent mineralocorticoid excess	10.5	NR3C2 POMC REN
39	lipoid congenital adrenal hyperplasia	10.5	CYP11B1 CYP11B2 POMC REN
40	substernal goiter	10.5	PTH TG
41	arthrogryposis, distal, type 3	10.5	NR3C2 REN
42	thyroid crisis	10.4	POMC PTH TG
43	pseudohyperkalemia, familial, 2, due to red cell leak	10.4	CYP11B2 NR3C2 REN
44	fasting hypoglycemia	10.4	CRH IGF1 POMC
45	craniopharyngioma	10.4	IGF1 PRL TRH
46	pituitary infarct	10.4	IGF1 POMC PRL SST
47	hyperparathyroidism 3	10.4	CDC73 MEN1
48	persistent fetal circulation syndrome	10.4	CRH IGF1 POMC
49	postsurgical hypothyroidism	10.4	PTH TG
50	glucose metabolism disease	10.4	IGF1 POMC REN SST

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:

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Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.23	ATP1A1 ATP1A4 CYP11B1 IGF1 KCNJ5 MEN1

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.41	CYP11B2 CDC73 AIP CRH ATP1A1 ATP1A4
2	growth/size/body region	MP:0005378	10.39	CACNA1D CYP11B2 CDC73 AIP CRH ATP1A4
3	cardiovascular system	MP:0005385	10.32	CYP11B1 CACNA1D CYP11B2 CDC73 AIP ATP1A1
4	endocrine/exocrine gland	MP:0005379	10.32	CYP11B1 CACNA1D CYP11B2 CDC73 AIP CRH
5	cellular	MP:0005384	10.24	CYP11B1 CACNA1D CDC73 AIP CRH ATP1A4
6	immune system	MP:0005387	10.14	CDC73 CRH POMC PRL MEN1 CYP11B2
7	mortality/aging	MP:0010768	10.1	CYP11B1 CACNA1D CDC73 AIP ATP1A1 IGF1
8	liver/biliary system	MP:0005370	9.97	CDC73 AIP CRH POMC PRL MEN1
9	muscle	MP:0005369	9.8	CYP11B1 CDC73 ATP1A1 IGF1 MEN1 NR3C2
10	nervous system	MP:0003631	9.8	CACNA1D CYP11B2 CDC73 CRH PRL MEN1
11	neoplasm	MP:0002006	9.63	CDC73 AIP IGF1 POMC PRL MEN1
12	renal/urinary system	MP:0005367	9.23	CYP11B1 CYP11B2 CDC73 CRH NR3C2 IGF1

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Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

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Genetic Tests for Endocrine Organ Benign Neoplasm

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Anatomical Context for Endocrine Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

¹⁹

Endocrine Gl

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Publications for Endocrine Organ Benign Neoplasm

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Genes for Endocrine Organ Benign Neoplasm

Genes related to Endocrine Organ Benign Neoplasm (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	19.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	REN	Renin	Protein Coding	18.97	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PRL	Prolactin	Protein Coding	18.87	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PTH	Parathyroid Hormone	Protein Coding	18.54	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	18.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MEN1	Menin 1	Protein Coding	17.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	17.81	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	KCNJ5	Potassium Voltage-Gated Channel Subfamily J Member 5	Protein Coding	17.79	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	SST	Somatostatin	Protein Coding	17.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	17.49	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	IGF1	Insulin Like Growth Factor 1	Protein Coding	17.31	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	TRH	Thyrotropin Releasing Hormone	Protein Coding	17.24	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	ATP1A1	ATPase Na+/K+ Transporting Subunit Alpha 1	Protein Coding	17.03	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	ATP1A4	ATPase Na+/K+ Transporting Subunit Alpha 4	Protein Coding	17.02	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
15	CRH	Corticotropin Releasing Hormone	Protein Coding	16.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
16	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	16.92	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
17	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	16.82	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
18	CDC73	Cell Division Cycle 73	Protein Coding	16.74	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
19	GHRH	Growth Hormone Releasing Hormone	Protein Coding	16.39	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
20	TG	Thyroglobulin	Protein Coding	16.35	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Endocrine Organ Benign Neoplasm

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Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

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Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Myometrial Relaxation and Contraction Pathways ¹ Show member pathways Calcium Regulation in the Cardiac Cell ¹	12.3	ATP1A4 CACNA1D CRH KCNJ5
2	Aldosterone synthesis and secretion ³⁷ Show member pathways Adrenergic signaling in cardiomyocytes ³⁷ Ca2+ activated K+ channels ⁶⁶ Cortisol synthesis and secretion ³⁷ Cushing's syndrome ³⁷ Insulin secretion ³⁷ Melanogenesis ³⁷ Thyroid hormone synthesis ³⁷	12.22	AIP ATP1A1 ATP1A4 CACNA1D CRH CYP11B1
3	Corticotropin-releasing hormone signaling pathway ¹	11.64	CRH CYP11B1 POMC
4	G alpha (s) signalling events ⁶⁶	11.62	CRH GHRH POMC PTH
5	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid andamp; Mineralcorticoid Metabolism ¹ glucocorticoid biosynthesis ¹ Glucocorticoid biosynthesis ⁶⁶ mineralocorticoid biosynthesis ¹ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.6	CYP11B1 CYP11B2 POMC
6	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶¹ Show member pathways ACE Inhibitor Pathway ¹ ACE Inhibitor Pathway, Pharmacodynamics ⁶¹ Renin-angiotensin system ³⁷	11.54	CYP11B2 NR3C2 REN
7	Cardiac muscle contraction ³⁷	11.5	ATP1A1 ATP1A4 CACNA1D
8	Antiarrhythmic Pathway, Pharmacodynamics ⁶¹	11.29	ATP1A1 CACNA1D KCNJ5
9	Carbohydrate digestion and absorption ³⁷	11.08	ATP1A1 ATP1A4 CACNA1D
10	Aldosterone-regulated sodium reabsorption ³⁷	10.82	ATP1A1 ATP1A4 IGF1 NR3C2
11	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶¹	10.25	CRH POMC
12	Thyroxine (Thyroid Hormone) Production ¹	10.1	TG TRH

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GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	CRH GHRH IGF1 POMC PRL PTH
2	extracellular space	GO:0005615	9.28	CRH GHRH IGF1 POMC PRL PTH
3	sodium:potassium-exchanging ATPase complex	GO:0005890	9.16	ATP1A1 ATP1A4

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.93	GHRH POMC PTH SST TRH
2	response to drug	GO:0042493	9.91	ATP1A1 CRH PTH REN SST
3	glucose homeostasis	GO:0042593	9.81	CYP11B1 IGF1 POMC
4	response to nutrient levels	GO:0031667	9.72	IGF1 PRL PTH
5	potassium ion import	GO:0010107	9.67	ATP1A1 ATP1A4 KCNJ5
6	cellular sodium ion homeostasis	GO:0006883	9.64	ATP1A1 ATP1A4
7	cardiac muscle cell action potential involved in contraction	GO:0086002	9.63	ATP1A1 CACNA1D
8	positive regulation of glycogen biosynthetic process	GO:0045725	9.62	IGF1 PTH
9	cellular potassium ion homeostasis	GO:0030007	9.62	ATP1A1 ATP1A4
10	response to corticosterone	GO:0051412	9.61	CRH TRH
11	sodium ion export across plasma membrane	GO:0036376	9.61	ATP1A1 ATP1A4
12	establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	9.6	ATP1A1 ATP1A4
13	positive regulation of insulin-like growth factor receptor signaling pathway	GO:0043568	9.59	GHRH IGF1
14	C21-steroid hormone biosynthetic process	GO:0006700	9.58	CYP11B1 CYP11B2
15	small molecule metabolic process	GO:0044281	9.58	CYP11B1 CYP11B2
16	cellular response to potassium ion	GO:0035865	9.57	CYP11B1 CYP11B2
17	potassium ion import across plasma membrane	GO:1990573	9.56	ATP1A1 KCNJ5
18	regulation of blood pressure	GO:0008217	9.56	ATP1A1 CYP11B1 POMC REN
19	secondary metabolite biosynthetic process	GO:0044550	9.52	CYP11B1 CYP11B2
20	cellular response to peptide hormone stimulus	GO:0071375	9.5	CYP11B1 CYP11B2 MEN1
21	dehydroaustinol biosynthetic process	GO:1900563	9.48	CYP11B1 CYP11B2
22	cortisol metabolic process	GO:0034650	9.46	CYP11B1 CYP11B2
23	aldosterone biosynthetic process	GO:0032342	9.43	CYP11B1 CYP11B2
24	austinol biosynthetic process	GO:1900560	9.4	CYP11B1 CYP11B2
25	cortisol biosynthetic process	GO:0034651	9.37	CYP11B1 CYP11B2
26	glucocorticoid biosynthetic process	GO:0006704	9.33	CRH CYP11B1 CYP11B2
27	regulation of signaling receptor activity	GO:0010469	9.23	GHRH IGF1 POMC PRL PTH SST
28	hormone-mediated apoptotic signaling pathway	GO:0008628	9.13	CRH PTH SST

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	insulin-like growth factor receptor binding	GO:0005159	9.32	IGF1 REN
2	sodium:potassium-exchanging ATPase activity	GO:0005391	9.26	ATP1A1 ATP1A4
3	hormone activity	GO:0005179	9.23	CRH IGF1 POMC PRL PTH SST
4	corticosterone 18-monooxygenase activity	GO:0047783	9.16	CYP11B1 CYP11B2
5	steroid 11-beta-monooxygenase activity	GO:0004507	8.96	CYP11B1 CYP11B2

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