Endocrine Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm ¹¹ ¹⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060089

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Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology: ¹¹ An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary: Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is MIR483 (MicroRNA 483), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Sudden infant death syndrome (SIDS) susceptibility pathways. Affiliated tissues include endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body, and related phenotypes are neoplasm and no phenotypic analysis

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Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal adenoma	32.7	REN POMC MIR483 MEN1
2	pheochromocytoma	32.4	SST SDHD SDHB RET REN PRL
3	benign exocrine pancreas neoplasm	11.3
4	pineocytoma	11.3
5	bronchial adenomas/carcinoids childhood	10.5	SST POMC
6	chiasmal syndrome	10.5	SST PRL POMC
7	sporadic pheochromocytoma/secreting paraganglioma	10.5	SDHD SDHB RET
8	prolactin producing pituitary tumor	10.5	PRL POMC MEN1
9	parathyroid transitional clear cell adenoma	10.5	PTH MEN1
10	acidophil adenoma	10.5	SST PRL POMC
11	nodular goiter	10.5	RET PTH MIR199A1
12	tsh producing pituitary tumor	10.5	SST PRL POMC
13	nonsyndromic paraganglioma	10.5	SDHB RET CHGA
14	pituitary-dependent cushing's disease	10.5	SST PRL POMC
15	carotid body cancer	10.5	SDHD SDHB CHGA
16	neural crest tumor	10.5	SDHD SDHB
17	peripartum cardiomyopathy	10.5	PRL MIR21 MIR199A1
18	goiter	10.5	SST RET PRL
19	cranial nerve palsy	10.5	SDHD SDHB PRL POMC
20	nelson syndrome	10.5	SST PRL POMC
21	hypocalciuric hypercalcemia, familial, type i	10.5	PTH MIR139 MEN1
22	hypocalciuric hypercalcemia, familial, type ii	10.5	PTH MIR139 MEN1
23	cerebral angioma	10.5	SDHD SDHB RET
24	thyroid dyshormonogenesis 2a	10.5	SST RET POMC
25	pituitary apoplexy	10.5	SST PRL POMC
26	miyoshi muscular dystrophy 1	10.5	MIR221 MIR210 MIR21
27	glioma	10.5	NGF MIR221 MIR210 MIR21
28	primary pigmented nodular adrenocortical disease	10.5	PRL POMC MIR483 MEN1
29	paragangliomas 4	10.5	SDHD SDHB
30	inappropriate adh syndrome	10.5	REN PRL POMC
31	pituitary infarct	10.5	SST PRL POMC MEN1
32	horner's syndrome	10.5	SDHD SDHB NGF
33	substernal goiter	10.5	RET PTH
34	hypoaldosteronism	10.5	REN POMC
35	non-functioning pancreatic endocrine tumor	10.5	SST MEN1 CHGA
36	steroid inherited metabolic disorder	10.5	REN PRL POMC
37	carcinoid syndrome	10.5	SST SDHD CHGA
38	gastric leiomyosarcoma	10.5	SDHD SDHB
39	pituitary adenoma 1, multiple types	10.5	SST PRL MEN1
40	endometriosis of ovary	10.5	MIR221 MIR199A1 MIR139
41	gastric gastrinoma	10.5	SST MEN1 CHGA
42	central nervous system benign neoplasm	10.5	POMC MIR21 MIR199A1 MIR139
43	functionless pituitary adenoma	10.5	SST POMC
44	hormone producing pituitary cancer	10.5	SST PRL POMC MEN1
45	ectopic cushing syndrome	10.5	SST PRL POMC CHGA
46	hyperpituitarism	10.5	SST PRL POMC MEN1
47	tuberculum sellae meningioma	10.5	PRL POMC
48	pancreatic cholera	10.5	SST MEN1 CHGA
49	lymph node disease	10.5	SDHD SDHB RET MIR483
50	gastrointestinal neuroendocrine benign tumor	10.5	SST MEN1 CHGA

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:

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Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.7	MEN1 MIR139 POMC PRL RET SDHB
2	no phenotypic analysis	MP:0003012	9.61	CHGA MIR126 MIR199A1 MIR210 NGF POMC
3	mortality/aging	MP:0010768	9.47	CHGA MEN1 MIR126 MIR139 MIR199A1 MIR210

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Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials, NIH Clinical Center for Endocrine Organ Benign Neoplasm

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Genetic Tests for Endocrine Organ Benign Neoplasm

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Anatomical Context for Endocrine Organ Benign Neoplasm

Organs/tissues related to Endocrine Organ Benign Neoplasm:

FMA: Endocrine Glands Which Secretes A Type Of Hormone Directly Into The Bloodstream To Regulate The Body

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Publications for Endocrine Organ Benign Neoplasm

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Genes for Endocrine Organ Benign Neoplasm

Genes related to Endocrine Organ Benign Neoplasm (0 elite genes):

(show top 50) (show all 68)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR483	MicroRNA 483	RNA Gene	10.16	DISEASES inferred ¹⁴ ¹⁴
2	MIR199A1	MicroRNA 199a-1	RNA Gene	9.97	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
3	POMC	Proopiomelanocortin	Protein Coding	9.56	DISEASES inferred ¹⁴
4	MIR139	MicroRNA 139	RNA Gene	9.38	DISEASES inferred ¹⁴ ¹⁴
5	MIR21	MicroRNA 21	RNA Gene	9.27	DISEASES inferred ¹⁴ ¹⁴
6	PRL	Prolactin	Protein Coding	9.21	DISEASES inferred ¹⁴
7	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	9.15	DISEASES inferred ¹⁴
8	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	9.1	DISEASES inferred ¹⁴
9	PTH	Parathyroid Hormone	Protein Coding	8.86	DISEASES inferred ¹⁴
10	MIR221	MicroRNA 221	RNA Gene	8.77	DISEASES inferred ¹⁴ ¹⁴
11	MIR210	MicroRNA 210	RNA Gene	8.76	DISEASES inferred ¹⁴ ¹⁴
12	RET	Ret Proto-Oncogene	Protein Coding	8.74	DISEASES inferred ¹⁴
13	MEN1	Menin 1	Protein Coding	8.73	DISEASES inferred ¹⁴
14	SST	Somatostatin	Protein Coding	8.69	DISEASES inferred ¹⁴
15	MIR126	MicroRNA 126	RNA Gene	8.62	DISEASES inferred ¹⁴ ¹⁴
16	REN	Renin	Protein Coding	8.62	DISEASES inferred ¹⁴
17	MIR183	MicroRNA 183	RNA Gene	8.47	DISEASES inferred ¹⁴ ¹⁴
18	NGF	Nerve Growth Factor	Protein Coding	8.41	DISEASES inferred ¹⁴
19	CHGA	Chromogranin A	Protein Coding	8.39	DISEASES inferred ¹⁴
20	MEG8	Maternally Expressed 8, Small Nucleolar RNA Host Gene	RNA Gene	8.38	DISEASES inferred ¹⁴ ¹⁴
21	MIR93	MicroRNA 93	RNA Gene	8.34	DISEASES inferred ¹⁴ ¹⁴
22	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	8.3	DISEASES inferred ¹⁴
23	TMEM127	Transmembrane Protein 127	Protein Coding	8.27	DISEASES inferred ¹⁴
24	MIR582	MicroRNA 582	RNA Gene	8.24	DISEASES inferred ¹⁴ ¹⁴
25	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	8.23	DISEASES inferred ¹⁴
26	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	8.21	DISEASES inferred ¹⁴
27	SYP	Synaptophysin	Protein Coding	8.2	DISEASES inferred ¹⁴
28	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	8.16	DISEASES inferred ¹⁴
29	IGF1	Insulin Like Growth Factor 1	Protein Coding	8.08	DISEASES inferred ¹⁴
30	MIR26A1	MicroRNA 26a-1	RNA Gene	8.06	DISEASES inferred ¹⁴ ¹⁴
31	NF1	Neurofibromin 1	Protein Coding	8.06	DISEASES inferred ¹⁴
32	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	7.98	DISEASES inferred ¹⁴
33	MIR145	MicroRNA 145	RNA Gene	7.96	DISEASES inferred ¹⁴ ¹⁴
34	MIR138-1	MicroRNA 138-1	RNA Gene	7.95	DISEASES inferred ¹⁴ ¹⁴
35	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	7.94	DISEASES inferred ¹⁴
36	H2AC18	H2A Clustered Histone 18	Protein Coding	7.94	DISEASES inferred ¹⁴ ¹⁴
37	KCNJ5	Potassium Inwardly Rectifying Channel Subfamily J Member 5	Protein Coding	7.9	DISEASES inferred ¹⁴
38	KDM4C	Lysine Demethylase 4C	Protein Coding	7.86	DISEASES inferred ¹⁴ ¹⁴
39	NR3C2	Nuclear Receptor Subfamily 3 Group C Member 2	Protein Coding	7.75	DISEASES inferred ¹⁴
40	MIR335	MicroRNA 335	RNA Gene	7.67	DISEASES inferred ¹⁴ ¹⁴
41	MIR10B	MicroRNA 10b	RNA Gene	7.66	DISEASES inferred ¹⁴ ¹⁴
42	CDC73	Cell Division Cycle 73	Protein Coding	7.64	DISEASES inferred ¹⁴
43	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	7.64	DISEASES inferred ¹⁴
44	MIR338	MicroRNA 338	RNA Gene	7.59	DISEASES inferred ¹⁴ ¹⁴
45	CRH	Corticotropin Releasing Hormone	Protein Coding	7.59	DISEASES inferred ¹⁴
46	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	7.59	DISEASES inferred ¹⁴
47	TP53	Tumor Protein P53	Protein Coding	7.58	DISEASES inferred ¹⁴
48	FH	Fumarate Hydratase	Protein Coding	7.58	DISEASES inferred ¹⁴
49	SSTR5	Somatostatin Receptor 5	Protein Coding	7.57	DISEASES inferred ¹⁴
50	MIR17	MicroRNA 17	RNA Gene	7.56	DISEASES inferred ¹⁴ ¹⁴

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Variations for Endocrine Organ Benign Neoplasm

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Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

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Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	miRNAs involved in DNA damage response ⁷⁴	11.16	MIR221 MIR210 MIR21
2	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	11.13	SST RET NGF MIR210
3	miRNAs involvement in the immune response in sepsis ⁷⁴	10.92	MIR21 MIR199A1 MIR126
4	Mitochondrial complex II assembly ⁷⁴ Show member pathways aerobic respiration I (cytochrome c) ⁶¹	10.34	SDHD SDHB

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GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RISC complex	GO:0016442	9.8	MIR221 MIR210 MIR21 MIR199A1 MIR183 MIR139
2	extracellular space	GO:0005615	9.64	SST REN PTH PRL POMC NGF
3	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	9.46	SDHD SDHB

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of angiogenesis	GO:0045766	9.78	MIR210 MIR21 MIR199A1 MIR126
2	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.76	SDHD SDHB
3	miRNA-mediated gene silencing	GO:0035195	9.7	MIR483 MIR221 MIR210 MIR21 MIR199A1 MIR183
4	hormone-mediated apoptotic signaling pathway	GO:0008628	9.67	SST PTH
5	positive regulation of protein kinase B signaling	GO:0051897	9.63	MIR126 MIR199A1 MIR21 MIR221 RET
6	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.61	MIR221 MIR210 MIR126
7	negative regulation of cell migration involved in sprouting angiogenesis	GO:0090051	9.5	MIR483 MIR221 MIR199A1
8	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.4	MIR210 MIR21
9	negative regulation of interleukin-21 production	GO:0032705	9.26	MIR221 MIR21
10	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.02	MIR483 MIR221 MIR210 MIR21 MIR126

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.86	SST PTH PRL POMC
2	ubiquinone binding	GO:0048039	9.62	SDHD SDHB
3	mRNA 3'-UTR binding	GO:0003730	9.56	MIR483 MIR210 MIR21 MIR199A1 MIR183 MIR139
4	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.46	SDHD SDHB
5	mRNA base-pairing translational repressor activity	GO:1903231	9.28	MIR483 MIR221 MIR210 MIR21 MIR199A1 MIR183

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Sources for Endocrine Organ Benign Neoplasm

¹ BitterDB

² CDC

³ Cell Signaling Technology

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⁸ Cosmic

⁹ dbSNP

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¹¹ Disease Ontology

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¹⁵ DrugBank

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¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

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²⁹ HMDB

³⁰ HPO

³¹ ICD10

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³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

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⁴⁰ MedGen

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⁵¹ NIH Clinical Center

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⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: END036 MIFTS: 24	Endocrine Organ Benign Neoplasm Categories: Cancer diseases, Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
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