Endocrine Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: END036 MIFTS: 31	Endocrine Organ Benign Neoplasm Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060089

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Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Carbon metabolism and Citrate cycle (TCA cycle). Affiliated tissues include pituitary, thyroid and kidney, and related phenotypes are no effect and homeostasis/metabolism

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Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal adenoma	32.3	CYP11B2 MEN1 POMC REN
2	pheochromocytoma	30.4	ADM CALCA CHGA MEN1 NGF POMC
3	bronchus adenoma	10.5	POMC SST
4	bronchial adenomas/carcinoids childhood	10.5	POMC SST
5	parathyroid transitional clear cell adenoma	10.5	MEN1 PTH
6	clear cell adenoma	10.5	MEN1 PTH
7	acidophil adenoma	10.5	POMC SST
8	acute adrenal insufficiency	10.5	POMC REN
9	adenohypophysitis	10.5	POMC PRL
10	pituitary infarct	10.4	POMC PRL SST
11	chiasmal syndrome	10.4	POMC PRL SST
12	chondroma	10.4	SDHB SDHC SDHD
13	paraganglioma and gastric stromal sarcoma	10.4	SDHB SDHC SDHD
14	premenstrual tension	10.4	POMC PRL REN
15	carney triad	10.4	SDHB SDHC SDHD
16	nelson syndrome	10.4	POMC PRL SST
17	scleredema adultorum	10.4	INS POMC PTH
18	sclerosing hepatic carcinoma	10.4	CHGA PTH
19	sheehan syndrome	10.4	INS POMC PRL
20	tsh producing pituitary tumor	10.4	POMC PRL SST
21	hypothalamic disease	10.4	POMC PRL
22	hypoaldosteronism	10.4	CYP11B2 POMC REN
23	silent pituitary adenoma	10.4	AIP MEN1
24	null pituitary adenoma	10.4	AIP MEN1
25	familial isolated hyperparathyroidism	10.4	MEN1 PTH RET
26	chromophobe adenoma	10.4	INS POMC PRL
27	pancreatic endocrine carcinoma	10.4	INS POMC SST
28	steroid inherited metabolic disorder	10.4	CYP11B2 POMC REN
29	hyperaldosteronism, familial, type i	10.4	CYP11B2 POMC REN
30	inappropriate adh syndrome	10.4	POMC REN
31	algoneurodystrophy	10.4	CALCA NGF
32	gastrointestinal neuroendocrine benign tumor	10.4	CHGA SST
33	adrenal rest tumor	10.4	CYP11B2 POMC PRL
34	hyperprolactinemia	10.4	POMC PRL SST
35	wdha syndrome	10.4	CALCA SST
36	fibrogenesis imperfecta ossium	10.4	CALCA PTH
37	hyperandrogenism	10.4	INS POMC PRL
38	cortical thymoma	10.4	NGF SST
39	hypopituitarism	10.4	INS POMC PRL
40	sella turcica neoplasm	10.4	POMC PRL
41	gastrointestinal neuroendocrine tumor	10.4	CHGA SST
42	gastric neuroendocrine neoplasm	10.3	CHGA SST
43	postgastrectomy syndrome	10.3	INS SST
44	gonadal disease	10.3	INS POMC PRL
45	granulosa cell tumor of the ovary	10.3	CHGA INS PRL
46	lipoid congenital adrenal hyperplasia	10.3	CYP11B2 POMC REN
47	sporadic pheochromocytoma	10.3	RET SDHB SDHC SDHD
48	duodenal gastrinoma	10.3	CHGA MEN1 SST
49	insulinomatosis and diabetes mellitus	10.3	CHGA INS SST
50	pancreas disease	10.3	INS POMC SST

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:

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Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	9.92	ADM AIP CALCA CHGA CYP11B2 INS

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

⁴⁷ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	ADM AIP CHGA CYP11B2 INS MEN1
2	cardiovascular system	MP:0005385	10.3	ADM AIP CHGA CYP11B2 INS MEN1
3	endocrine/exocrine gland	MP:0005379	10.29	ADM AIP CHGA CYP11B2 INS MEN1
4	growth/size/body region	MP:0005378	10.27	AIP CHGA CYP11B2 INS MEN1 NGF
5	hematopoietic system	MP:0005397	10.22	ADM CYP11B2 INS POMC PTH REN
6	mortality/aging	MP:0010768	10.21	ADM AIP CHGA INS MEN1 NGF
7	immune system	MP:0005387	10.17	ADM CYP11B2 INS MEN1 POMC PRL
8	liver/biliary system	MP:0005370	9.95	ADM AIP CYP11B2 INS MEN1 POMC
9	nervous system	MP:0003631	9.9	CHGA CYP11B2 INS MEN1 NGF POMC
10	muscle	MP:0005369	9.87	ADM CHGA INS MEN1 NGF REN
11	neoplasm	MP:0002006	9.8	AIP MEN1 POMC PRL RET SDHB
12	no phenotypic analysis	MP:0003012	9.56	CHGA INS NGF POMC RET SDHB
13	renal/urinary system	MP:0005367	9.23	ADM CHGA CYP11B2 INS POMC REN

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Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

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Genetic Tests for Endocrine Organ Benign Neoplasm

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Anatomical Context for Endocrine Organ Benign Neoplasm

MalaCards organs/tissues related to Endocrine Organ Benign Neoplasm:

⁴²

Pituitary, Thyroid, Kidney, Lymph Node, Pancreas, Cortex, Adrenal Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

²⁰

Endocrine Gl

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Publications for Endocrine Organ Benign Neoplasm

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Genes for Endocrine Organ Benign Neoplasm

Genes related to Endocrine Organ Benign Neoplasm (0 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	18.95	DISEASES inferred ¹⁵
2	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	18.86	DISEASES inferred ¹⁵
3	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	18.66	DISEASES inferred ¹⁵
4	PRL	Prolactin	Protein Coding	18.55	DISEASES inferred ¹⁵
5	REN	Renin	Protein Coding	18.48	DISEASES inferred ¹⁵
6	NGF	Nerve Growth Factor	Protein Coding	18.45	DISEASES inferred ¹⁵
7	PTH	Parathyroid Hormone	Protein Coding	18.35	DISEASES inferred ¹⁵
8	RET	Ret Proto-Oncogene	Protein Coding	18.21	DISEASES inferred ¹⁵
9	MEN1	Menin 1	Protein Coding	18.18	DISEASES inferred ¹⁵
10	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	18.09	DISEASES inferred ¹⁵
11	SST	Somatostatin	Protein Coding	18.02	DISEASES inferred ¹⁵
12	INS	Insulin	Protein Coding	17.94	DISEASES inferred ¹⁵
13	CHGA	Chromogranin A	Protein Coding	17.7	DISEASES inferred ¹⁵
14	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	17.6	DISEASES inferred ¹⁵
15	ADM	Adrenomedullin	Protein Coding	17.46	DISEASES inferred ¹⁵
16	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	17.43	DISEASES inferred ¹⁵
17	TMEM127	Transmembrane Protein 127	Protein Coding	17.42	DISEASES inferred ¹⁵
18	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	17.33	DISEASES inferred ¹⁵
19	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	17.32	DISEASES inferred ¹⁵
20	PGLS	6-Phosphogluconolactonase	Protein Coding	7.63	DISEASES inferred ¹⁵
21	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	7.28	DISEASES inferred ¹⁵
22	KCNJ5	Potassium Voltage-Gated Channel Subfamily J Member 5	Protein Coding	7.21	DISEASES inferred ¹⁵
23	SYP	Synaptophysin	Protein Coding	7.15	DISEASES inferred ¹⁵
24	IGF1	Insulin Like Growth Factor 1	Protein Coding	7.14	DISEASES inferred ¹⁵
25	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	7.02	DISEASES inferred ¹⁵
26	TRH	Thyrotropin Releasing Hormone	Protein Coding	6.88	DISEASES inferred ¹⁵

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Variations for Endocrine Organ Benign Neoplasm

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Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

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Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Carbon metabolism ³⁸ Show member pathways 2-Oxocarboxylic acid metabolism ³⁸ Biosynthesis of amino acids ³⁸ formaldehyde oxidation ¹	11.58	PGLS SDHB SDHC SDHD
2	Citrate cycle (TCA cycle) ³⁸ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.34	SDHB SDHC SDHD
3	G alpha (s) signalling events ⁶⁷	11.09	ADM CALCA POMC PTH

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GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.96	ADM CALCA CHGA INS NGF POMC
2	extracellular space	GO:0005615	9.65	ADM CALCA CHGA INS NGF POMC
3	endosome lumen	GO:0031904	9.37	INS PRL
4	secretory granule	GO:0030141	9.32	CHGA POMC
5	respiratory chain complex II	GO:0045273	9.16	SDHB SDHC
6	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.8	SDHB SDHC SDHD

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.88	ADM MEN1 NGF SST TMEM127
2	cellular protein metabolic process	GO:0044267	9.8	CALCA INS MEN1 PRL
3	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.71	ADM CALCA PTH
4	response to drug	GO:0042493	9.71	PTH REN RET SST
5	cell-cell signaling	GO:0007267	9.65	CALCA INS POMC PTH SST
6	regulation of blood pressure	GO:0008217	9.62	CALCA CHGA POMC REN
7	positive regulation of glycogen biosynthetic process	GO:0045725	9.55	INS PTH
8	positive regulation of blood vessel diameter	GO:0097755	9.54	ADM CALCA INS
9	G protein-coupled receptor internalization	GO:0002031	9.52	ADM CALCA
10	negative regulation of blood vessel diameter	GO:0097756	9.51	CHGA INS
11	amylin receptor signaling pathway	GO:0097647	9.46	ADM CALCA
12	hormone-mediated apoptotic signaling pathway	GO:0008628	9.43	PTH SST
13	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	9.33	SDHAF2 SDHC SDHD
14	tricarboxylic acid cycle	GO:0006099	9.26	SDHAF2 SDHB SDHC SDHD
15	regulation of signaling receptor activity	GO:0010469	9.23	ADM CALCA INS NGF POMC PRL

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.65	ADM CALCA NGF POMC REN
2	electron transfer activity	GO:0009055	9.5	SDHB SDHC SDHD
3	insulin-like growth factor receptor binding	GO:0005159	9.37	INS REN
4	hormone activity	GO:0005179	9.17	ADM CALCA INS POMC PRL PTH
5	ubiquinone binding	GO:0048039	9.16	SDHB SDHD
6	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.13	SDHB SDHC SDHD

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