MCID: END036
MIFTS: 31

Endocrine Organ Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060089

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Carbon metabolism and Citrate cycle (TCA cycle). Affiliated tissues include lung, kidney and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 32.1 CYP11B2 MEN1 POMC REN
2 pheochromocytoma 31.2 ADM CALCA CHGA MEN1 NGF POMC
3 bronchus adenoma 10.3 POMC SST
4 bronchial adenomas/carcinoids childhood 10.3 POMC SST
5 acidophil adenoma 10.3 POMC SST
6 parathyroid transitional clear cell adenoma 10.3 MEN1 PTH
7 clear cell adenoma 10.3 MEN1 PTH
8 acute adrenal insufficiency 10.3 POMC REN
9 adenohypophysitis 10.3 POMC PRL
10 pituitary infarct 10.3 POMC PRL SST
11 chiasmal syndrome 10.3 POMC PRL SST
12 chondroma 10.3 SDHB SDHC SDHD
13 paraganglioma and gastric stromal sarcoma 10.3 SDHB SDHC SDHD
14 carney triad 10.3 SDHB SDHC SDHD
15 premenstrual tension 10.3 POMC PRL REN
16 nelson syndrome 10.3 POMC PRL SST
17 pituitary apoplexy 10.3 INS POMC PRL
18 sclerosing hepatic carcinoma 10.3 CHGA PTH
19 scleredema adultorum 10.3 INS POMC PTH
20 tsh producing pituitary tumor 10.3 POMC PRL SST
21 sheehan syndrome 10.3 INS POMC PRL
22 hypothalamic disease 10.3 POMC PRL
23 hypoaldosteronism 10.3 CYP11B2 POMC REN
24 sex differentiation disease 10.3 INS POMC PRL
25 familial isolated hyperparathyroidism 10.3 MEN1 PTH RET
26 algoneurodystrophy 10.3 CALCA NGF
27 adenoma of the pancreas 10.3 CHGA SST
28 chromophobe adenoma 10.3 INS POMC PRL
29 pancreatic endocrine carcinoma 10.3 INS POMC SST
30 steroid inherited metabolic disorder 10.3 CYP11B2 POMC REN
31 multiple endocrine neoplasia, type iv 10.3 MEN1 PRL RET
32 hyperaldosteronism, familial, type i 10.2 CYP11B2 POMC REN
33 inappropriate adh syndrome 10.2 POMC REN
34 postural hypotension 10.2 INS REN SST
35 gastrointestinal neuroendocrine benign tumor 10.2 CHGA SST
36 hyperprolactinemia 10.2 POMC PRL SST
37 adrenal rest tumor 10.2 CYP11B2 POMC PRL
38 wdha syndrome 10.2 CALCA SST
39 cortical thymoma 10.2 NGF SST
40 fibrogenesis imperfecta ossium 10.2 CALCA PTH
41 hyperandrogenism 10.2 INS POMC PRL
42 hypopituitarism 10.2 INS POMC PRL
43 gastrointestinal neuroendocrine tumor 10.2 CHGA SST
44 gastric neuroendocrine neoplasm 10.2 CHGA SST
45 postgastrectomy syndrome 10.2 INS SST
46 gonadal disease 10.2 INS POMC PRL
47 sporadic pheochromocytoma 10.2 RET SDHB SDHC SDHD
48 granulosa cell tumor of the ovary 10.2 CHGA INS PRL
49 duodenal gastrinoma 10.2 CHGA MEN1 SST
50 lipoid congenital adrenal hyperplasia 10.2 CYP11B2 POMC REN

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:



Diseases related to Endocrine Organ Benign Neoplasm

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 ADM CHGA CYP11B2 INS MEN1 NGF
2 cardiovascular system MP:0005385 10.29 ADM CHGA CYP11B2 INS MEN1 NGF
3 endocrine/exocrine gland MP:0005379 10.24 ADM CHGA CYP11B2 INS MEN1 POMC
4 growth/size/body region MP:0005378 10.22 CHGA CYP11B2 INS MEN1 NGF POMC
5 hematopoietic system MP:0005397 10.2 ADM CYP11B2 INS POMC PTH REN
6 mortality/aging MP:0010768 10.18 ADM CHGA INS MEN1 NGF POMC
7 immune system MP:0005387 10.14 ADM CYP11B2 INS MEN1 POMC PRL
8 nervous system MP:0003631 9.9 CHGA CYP11B2 INS MEN1 NGF POMC
9 muscle MP:0005369 9.87 ADM CHGA INS MEN1 NGF REN
10 neoplasm MP:0002006 9.73 MEN1 POMC PRL RET SDHB SDHD
11 no phenotypic analysis MP:0003012 9.56 CHGA INS NGF POMC RET SDHB
12 renal/urinary system MP:0005367 9.23 ADM CHGA CYP11B2 INS POMC REN

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

Genetic Tests for Endocrine Organ Benign Neoplasm

Anatomical Context for Endocrine Organ Benign Neoplasm

MalaCards organs/tissues related to Endocrine Organ Benign Neoplasm:

41
Lung, Kidney, Bone, Lymph Node, Ovary, Pituitary, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

19
Endocrine Gl

Publications for Endocrine Organ Benign Neoplasm

Variations for Endocrine Organ Benign Neoplasm

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Pathways for Endocrine Organ Benign Neoplasm

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 ADM CALCA CHGA INS NGF POMC
2 mitochondrial inner membrane GO:0005743 9.72 CYP11B2 ENSG00000255292 SDHB SDHC SDHD
3 extracellular space GO:0005615 9.65 ADM CALCA CHGA INS NGF POMC
4 secretory granule GO:0030141 9.54 CHGA POMC PRL
5 mitochondrial envelope GO:0005740 9.43 ENSG00000255292 SDHD
6 endosome lumen GO:0031904 9.4 INS PRL
7 respiratory chain complex II GO:0045273 9.16 SDHB SDHC
8 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 ENSG00000255292 SDHB SDHC SDHD

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 ADM MEN1 NGF SST TMEM127
2 cellular protein metabolic process GO:0044267 9.8 CALCA INS MEN1 PRL
3 response to drug GO:0042493 9.8 PRL PTH REN RET SST
4 regulation of signaling receptor activity GO:0010469 9.76 ADM CALCA INS NGF POMC PRL
5 cell-cell signaling GO:0007267 9.73 ADM CALCA INS POMC PTH SST
6 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.71 ADM CALCA PTH
7 regulation of blood pressure GO:0008217 9.62 CALCA CHGA POMC REN
8 positive regulation of glycogen biosynthetic process GO:0045725 9.55 INS PTH
9 positive regulation of blood vessel diameter GO:0097755 9.54 ADM CALCA INS
10 G protein-coupled receptor internalization GO:0002031 9.52 ADM CALCA
11 negative regulation of blood vessel diameter GO:0097756 9.51 CHGA INS
12 amylin receptor signaling pathway GO:0097647 9.46 ADM CALCA
13 hormone-mediated apoptotic signaling pathway GO:0008628 9.43 PTH SST
14 tricarboxylic acid cycle GO:0006099 9.35 ENSG00000255292 SDHAF2 SDHB SDHC SDHD
15 mitochondrial electron transport, succinate to ubiquinone GO:0006121 8.92 ENSG00000255292 SDHAF2 SDHC SDHD

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 ADM CALCA NGF POMC REN
2 heme binding GO:0020037 9.56 CYP11B2 ENSG00000255292 SDHC SDHD
3 electron transfer activity GO:0009055 9.54 SDHB SDHC SDHD
4 insulin-like growth factor receptor binding GO:0005159 9.4 INS REN
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.33 SDHB SDHC SDHD
6 ubiquinone binding GO:0048039 9.26 ENSG00000255292 SDHB SDHC SDHD
7 hormone activity GO:0005179 9.17 ADM CALCA INS POMC PRL PTH

Sources for Endocrine Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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