MCID: END036
MIFTS: 31

Endocrine Organ Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060089

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Carbon metabolism and Citrate cycle (TCA cycle). Affiliated tissues include pituitary, thyroid and kidney, and related phenotypes are no effect and homeostasis/metabolism

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 32.3 CYP11B2 MEN1 POMC REN
2 pheochromocytoma 30.4 ADM CALCA CHGA MEN1 NGF POMC
3 bronchus adenoma 10.5 POMC SST
4 bronchial adenomas/carcinoids childhood 10.5 POMC SST
5 parathyroid transitional clear cell adenoma 10.5 MEN1 PTH
6 clear cell adenoma 10.5 MEN1 PTH
7 acidophil adenoma 10.5 POMC SST
8 acute adrenal insufficiency 10.5 POMC REN
9 adenohypophysitis 10.5 POMC PRL
10 pituitary infarct 10.4 POMC PRL SST
11 chiasmal syndrome 10.4 POMC PRL SST
12 chondroma 10.4 SDHB SDHC SDHD
13 paraganglioma and gastric stromal sarcoma 10.4 SDHB SDHC SDHD
14 premenstrual tension 10.4 POMC PRL REN
15 carney triad 10.4 SDHB SDHC SDHD
16 nelson syndrome 10.4 POMC PRL SST
17 scleredema adultorum 10.4 INS POMC PTH
18 sclerosing hepatic carcinoma 10.4 CHGA PTH
19 sheehan syndrome 10.4 INS POMC PRL
20 tsh producing pituitary tumor 10.4 POMC PRL SST
21 hypothalamic disease 10.4 POMC PRL
22 hypoaldosteronism 10.4 CYP11B2 POMC REN
23 silent pituitary adenoma 10.4 AIP MEN1
24 null pituitary adenoma 10.4 AIP MEN1
25 familial isolated hyperparathyroidism 10.4 MEN1 PTH RET
26 chromophobe adenoma 10.4 INS POMC PRL
27 pancreatic endocrine carcinoma 10.4 INS POMC SST
28 steroid inherited metabolic disorder 10.4 CYP11B2 POMC REN
29 hyperaldosteronism, familial, type i 10.4 CYP11B2 POMC REN
30 inappropriate adh syndrome 10.4 POMC REN
31 algoneurodystrophy 10.4 CALCA NGF
32 gastrointestinal neuroendocrine benign tumor 10.4 CHGA SST
33 adrenal rest tumor 10.4 CYP11B2 POMC PRL
34 hyperprolactinemia 10.4 POMC PRL SST
35 wdha syndrome 10.4 CALCA SST
36 fibrogenesis imperfecta ossium 10.4 CALCA PTH
37 hyperandrogenism 10.4 INS POMC PRL
38 cortical thymoma 10.4 NGF SST
39 hypopituitarism 10.4 INS POMC PRL
40 sella turcica neoplasm 10.4 POMC PRL
41 gastrointestinal neuroendocrine tumor 10.4 CHGA SST
42 gastric neuroendocrine neoplasm 10.3 CHGA SST
43 postgastrectomy syndrome 10.3 INS SST
44 gonadal disease 10.3 INS POMC PRL
45 granulosa cell tumor of the ovary 10.3 CHGA INS PRL
46 lipoid congenital adrenal hyperplasia 10.3 CYP11B2 POMC REN
47 sporadic pheochromocytoma 10.3 RET SDHB SDHC SDHD
48 duodenal gastrinoma 10.3 CHGA MEN1 SST
49 insulinomatosis and diabetes mellitus 10.3 CHGA INS SST
50 pancreas disease 10.3 INS POMC SST

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:



Diseases related to Endocrine Organ Benign Neoplasm

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ADM AIP CALCA CHGA CYP11B2 INS

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ADM AIP CHGA CYP11B2 INS MEN1
2 cardiovascular system MP:0005385 10.3 ADM AIP CHGA CYP11B2 INS MEN1
3 endocrine/exocrine gland MP:0005379 10.29 ADM AIP CHGA CYP11B2 INS MEN1
4 growth/size/body region MP:0005378 10.27 AIP CHGA CYP11B2 INS MEN1 NGF
5 hematopoietic system MP:0005397 10.22 ADM CYP11B2 INS POMC PTH REN
6 mortality/aging MP:0010768 10.21 ADM AIP CHGA INS MEN1 NGF
7 immune system MP:0005387 10.17 ADM CYP11B2 INS MEN1 POMC PRL
8 liver/biliary system MP:0005370 9.95 ADM AIP CYP11B2 INS MEN1 POMC
9 nervous system MP:0003631 9.9 CHGA CYP11B2 INS MEN1 NGF POMC
10 muscle MP:0005369 9.87 ADM CHGA INS MEN1 NGF REN
11 neoplasm MP:0002006 9.8 AIP MEN1 POMC PRL RET SDHB
12 no phenotypic analysis MP:0003012 9.56 CHGA INS NGF POMC RET SDHB
13 renal/urinary system MP:0005367 9.23 ADM CHGA CYP11B2 INS POMC REN

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

Genetic Tests for Endocrine Organ Benign Neoplasm

Anatomical Context for Endocrine Organ Benign Neoplasm

MalaCards organs/tissues related to Endocrine Organ Benign Neoplasm:

42
Pituitary, Thyroid, Kidney, Lymph Node, Pancreas, Cortex, Adrenal Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

20
Endocrine Gl

Publications for Endocrine Organ Benign Neoplasm

Variations for Endocrine Organ Benign Neoplasm

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Pathways for Endocrine Organ Benign Neoplasm

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.96 ADM CALCA CHGA INS NGF POMC
2 extracellular space GO:0005615 9.65 ADM CALCA CHGA INS NGF POMC
3 endosome lumen GO:0031904 9.37 INS PRL
4 secretory granule GO:0030141 9.32 CHGA POMC
5 respiratory chain complex II GO:0045273 9.16 SDHB SDHC
6 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.8 SDHB SDHC SDHD

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 ADM MEN1 NGF SST TMEM127
2 cellular protein metabolic process GO:0044267 9.8 CALCA INS MEN1 PRL
3 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.71 ADM CALCA PTH
4 response to drug GO:0042493 9.71 PTH REN RET SST
5 cell-cell signaling GO:0007267 9.65 CALCA INS POMC PTH SST
6 regulation of blood pressure GO:0008217 9.62 CALCA CHGA POMC REN
7 positive regulation of glycogen biosynthetic process GO:0045725 9.55 INS PTH
8 positive regulation of blood vessel diameter GO:0097755 9.54 ADM CALCA INS
9 G protein-coupled receptor internalization GO:0002031 9.52 ADM CALCA
10 negative regulation of blood vessel diameter GO:0097756 9.51 CHGA INS
11 amylin receptor signaling pathway GO:0097647 9.46 ADM CALCA
12 hormone-mediated apoptotic signaling pathway GO:0008628 9.43 PTH SST
13 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.33 SDHAF2 SDHC SDHD
14 tricarboxylic acid cycle GO:0006099 9.26 SDHAF2 SDHB SDHC SDHD
15 regulation of signaling receptor activity GO:0010469 9.23 ADM CALCA INS NGF POMC PRL

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 ADM CALCA NGF POMC REN
2 electron transfer activity GO:0009055 9.5 SDHB SDHC SDHD
3 insulin-like growth factor receptor binding GO:0005159 9.37 INS REN
4 hormone activity GO:0005179 9.17 ADM CALCA INS POMC PRL PTH
5 ubiquinone binding GO:0048039 9.16 SDHB SDHD
6 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHB SDHC SDHD

Sources for Endocrine Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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38 KEGG
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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