Endocrine Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: END036 MIFTS: 31	Endocrine Organ Benign Neoplasm Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Pathways Expand all tables

Sources

Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060089

Sources

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : ¹² An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Carbon metabolism and Citrate cycle (TCA cycle). Affiliated tissues include lung, kidney and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Sources

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)

#	Related Disease	Score	Top Affiliating Genes
1	adrenal adenoma	32.1	CYP11B2 MEN1 POMC REN
2	pheochromocytoma	31.2	ADM CALCA CHGA MEN1 NGF POMC
3	bronchus adenoma	10.3	POMC SST
4	bronchial adenomas/carcinoids childhood	10.3	POMC SST
5	acidophil adenoma	10.3	POMC SST
6	parathyroid transitional clear cell adenoma	10.3	MEN1 PTH
7	clear cell adenoma	10.3	MEN1 PTH
8	acute adrenal insufficiency	10.3	POMC REN
9	adenohypophysitis	10.3	POMC PRL
10	pituitary infarct	10.3	POMC PRL SST
11	chiasmal syndrome	10.3	POMC PRL SST
12	chondroma	10.3	SDHB SDHC SDHD
13	paraganglioma and gastric stromal sarcoma	10.3	SDHB SDHC SDHD
14	carney triad	10.3	SDHB SDHC SDHD
15	premenstrual tension	10.3	POMC PRL REN
16	nelson syndrome	10.3	POMC PRL SST
17	pituitary apoplexy	10.3	INS POMC PRL
18	sclerosing hepatic carcinoma	10.3	CHGA PTH
19	scleredema adultorum	10.3	INS POMC PTH
20	tsh producing pituitary tumor	10.3	POMC PRL SST
21	sheehan syndrome	10.3	INS POMC PRL
22	hypothalamic disease	10.3	POMC PRL
23	hypoaldosteronism	10.3	CYP11B2 POMC REN
24	sex differentiation disease	10.3	INS POMC PRL
25	familial isolated hyperparathyroidism	10.3	MEN1 PTH RET
26	algoneurodystrophy	10.3	CALCA NGF
27	adenoma of the pancreas	10.3	CHGA SST
28	chromophobe adenoma	10.3	INS POMC PRL
29	pancreatic endocrine carcinoma	10.3	INS POMC SST
30	steroid inherited metabolic disorder	10.3	CYP11B2 POMC REN
31	multiple endocrine neoplasia, type iv	10.3	MEN1 PRL RET
32	hyperaldosteronism, familial, type i	10.2	CYP11B2 POMC REN
33	inappropriate adh syndrome	10.2	POMC REN
34	postural hypotension	10.2	INS REN SST
35	gastrointestinal neuroendocrine benign tumor	10.2	CHGA SST
36	hyperprolactinemia	10.2	POMC PRL SST
37	adrenal rest tumor	10.2	CYP11B2 POMC PRL
38	wdha syndrome	10.2	CALCA SST
39	cortical thymoma	10.2	NGF SST
40	fibrogenesis imperfecta ossium	10.2	CALCA PTH
41	hyperandrogenism	10.2	INS POMC PRL
42	hypopituitarism	10.2	INS POMC PRL
43	gastrointestinal neuroendocrine tumor	10.2	CHGA SST
44	gastric neuroendocrine neoplasm	10.2	CHGA SST
45	postgastrectomy syndrome	10.2	INS SST
46	gonadal disease	10.2	INS POMC PRL
47	sporadic pheochromocytoma	10.2	RET SDHB SDHC SDHD
48	granulosa cell tumor of the ovary	10.2	CHGA INS PRL
49	duodenal gastrinoma	10.2	CHGA MEN1 SST
50	lipoid congenital adrenal hyperplasia	10.2	CYP11B2 POMC REN

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:

Sources

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

⁴⁶ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.34	ADM CHGA CYP11B2 INS MEN1 NGF
2	cardiovascular system	MP:0005385	10.29	ADM CHGA CYP11B2 INS MEN1 NGF
3	endocrine/exocrine gland	MP:0005379	10.24	ADM CHGA CYP11B2 INS MEN1 POMC
4	growth/size/body region	MP:0005378	10.22	CHGA CYP11B2 INS MEN1 NGF POMC
5	hematopoietic system	MP:0005397	10.2	ADM CYP11B2 INS POMC PTH REN
6	mortality/aging	MP:0010768	10.18	ADM CHGA INS MEN1 NGF POMC
7	immune system	MP:0005387	10.14	ADM CYP11B2 INS MEN1 POMC PRL
8	nervous system	MP:0003631	9.9	CHGA CYP11B2 INS MEN1 NGF POMC
9	muscle	MP:0005369	9.87	ADM CHGA INS MEN1 NGF REN
10	neoplasm	MP:0002006	9.73	MEN1 POMC PRL RET SDHB SDHD
11	no phenotypic analysis	MP:0003012	9.56	CHGA INS NGF POMC RET SDHB
12	renal/urinary system	MP:0005367	9.23	ADM CHGA CYP11B2 INS POMC REN

Sources

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

Sources

Genetic Tests for Endocrine Organ Benign Neoplasm

Sources

Anatomical Context for Endocrine Organ Benign Neoplasm

MalaCards organs/tissues related to Endocrine Organ Benign Neoplasm:

⁴¹

Lung, Kidney, Bone, Lymph Node, Ovary, Pituitary, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

¹⁹

Endocrine Gl

Sources

Publications for Endocrine Organ Benign Neoplasm

Sources

Genes for Endocrine Organ Benign Neoplasm

Genes related to Endocrine Organ Benign Neoplasm (0 elite genes):

(show all 26)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	18.92	DISEASES inferred ¹⁵
2	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	18.84	DISEASES inferred ¹⁵
3	SDHD	Succinate Dehydrogenase Complex Subunit D	Protein Coding	18.65	DISEASES inferred ¹⁵
4	NGF	Nerve Growth Factor	Protein Coding	18.47	DISEASES inferred ¹⁵
5	PRL	Prolactin	Protein Coding	18.44	DISEASES inferred ¹⁵
6	REN	Renin	Protein Coding	18.43	DISEASES inferred ¹⁵
7	RET	Ret Proto-Oncogene	Protein Coding	18.22	DISEASES inferred ¹⁵
8	PTH	Parathyroid Hormone	Protein Coding	18.19	DISEASES inferred ¹⁵
9	MEN1	Menin 1	Protein Coding	18.18	DISEASES inferred ¹⁵
10	SDHC	Succinate Dehydrogenase Complex Subunit C	Protein Coding	18.08	DISEASES inferred ¹⁵
11	SST	Somatostatin	Protein Coding	17.97	DISEASES inferred ¹⁵
12	INS	Insulin	Protein Coding	17.91	DISEASES inferred ¹⁵
13	CHGA	Chromogranin A	Protein Coding	17.68	DISEASES inferred ¹⁵
14	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	17.54	DISEASES inferred ¹⁵
15	ADM	Adrenomedullin	Protein Coding	17.44	DISEASES inferred ¹⁵
16	SDHAF2	Succinate Dehydrogenase Complex Assembly Factor 2	Protein Coding	17.4	DISEASES inferred ¹⁵
17	TMEM127	Transmembrane Protein 127	Protein Coding	17.39	DISEASES inferred ¹⁵
18	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	17.32	DISEASES inferred ¹⁵
19	ENSG00000255292		Protein Coding	8.64	DISEASES inferred ¹⁵
20	PGLS	6-Phosphogluconolactonase	Protein Coding	7.59	DISEASES inferred ¹⁵
21	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	7.29	DISEASES inferred ¹⁵
22	SDHA	Succinate Dehydrogenase Complex Flavoprotein Subunit A	Protein Coding	7.24	DISEASES inferred ¹⁵
23	SYP	Synaptophysin	Protein Coding	7.18	DISEASES inferred ¹⁵
24	KCNJ5	Potassium Voltage-Gated Channel Subfamily J Member 5	Protein Coding	7.18	DISEASES inferred ¹⁵
25	IGF1	Insulin Like Growth Factor 1	Protein Coding	7.08	DISEASES inferred ¹⁵
26	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	7	DISEASES inferred ¹⁵

Sources

Variations for Endocrine Organ Benign Neoplasm

Sources

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Sources

Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Carbon metabolism ³⁷ Show member pathways 2-Oxocarboxylic acid metabolism ³⁷ Biosynthesis of amino acids ³⁷ formaldehyde oxidation ¹	11.58	PGLS SDHB SDHC SDHD
2	Citrate cycle (TCA cycle) ³⁷ Show member pathways pyruvate decarboxylation to acetyl CoA ¹ superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle ¹ TCA cycle ¹ TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) ¹	11.34	SDHB SDHC SDHD
3	G alpha (s) signalling events ⁶⁶	11.09	ADM CALCA POMC PTH

Sources

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.96	ADM CALCA CHGA INS NGF POMC
2	mitochondrial inner membrane	GO:0005743	9.72	CYP11B2 ENSG00000255292 SDHB SDHC SDHD
3	extracellular space	GO:0005615	9.65	ADM CALCA CHGA INS NGF POMC
4	secretory granule	GO:0030141	9.54	CHGA POMC PRL
5	mitochondrial envelope	GO:0005740	9.43	ENSG00000255292 SDHD
6	endosome lumen	GO:0031904	9.4	INS PRL
7	respiratory chain complex II	GO:0045273	9.16	SDHB SDHC
8	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	GO:0005749	8.92	ENSG00000255292 SDHB SDHC SDHD

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell proliferation	GO:0008285	9.88	ADM MEN1 NGF SST TMEM127
2	cellular protein metabolic process	GO:0044267	9.8	CALCA INS MEN1 PRL
3	response to drug	GO:0042493	9.8	PRL PTH REN RET SST
4	regulation of signaling receptor activity	GO:0010469	9.76	ADM CALCA INS NGF POMC PRL
5	cell-cell signaling	GO:0007267	9.73	ADM CALCA INS POMC PTH SST
6	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.71	ADM CALCA PTH
7	regulation of blood pressure	GO:0008217	9.62	CALCA CHGA POMC REN
8	positive regulation of glycogen biosynthetic process	GO:0045725	9.55	INS PTH
9	positive regulation of blood vessel diameter	GO:0097755	9.54	ADM CALCA INS
10	G protein-coupled receptor internalization	GO:0002031	9.52	ADM CALCA
11	negative regulation of blood vessel diameter	GO:0097756	9.51	CHGA INS
12	amylin receptor signaling pathway	GO:0097647	9.46	ADM CALCA
13	hormone-mediated apoptotic signaling pathway	GO:0008628	9.43	PTH SST
14	tricarboxylic acid cycle	GO:0006099	9.35	ENSG00000255292 SDHAF2 SDHB SDHC SDHD
15	mitochondrial electron transport, succinate to ubiquinone	GO:0006121	8.92	ENSG00000255292 SDHAF2 SDHC SDHD

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	9.72	ADM CALCA NGF POMC REN
2	heme binding	GO:0020037	9.56	CYP11B2 ENSG00000255292 SDHC SDHD
3	electron transfer activity	GO:0009055	9.54	SDHB SDHC SDHD
4	insulin-like growth factor receptor binding	GO:0005159	9.4	INS REN
5	succinate dehydrogenase (ubiquinone) activity	GO:0008177	9.33	SDHB SDHC SDHD
6	ubiquinone binding	GO:0048039	9.26	ENSG00000255292 SDHB SDHC SDHD
7	hormone activity	GO:0005179	9.17	ADM CALCA INS POMC PRL PTH

Sources

Sources for Endocrine Organ Benign Neoplasm

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia