MCID: END036
MIFTS: 29

Endocrine Organ Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060089

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and parathyroid transitional clear cell adenoma. An important gene associated with Endocrine Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Myometrial Relaxation and Contraction Pathways and Aldosterone synthesis and secretion. Affiliated tissues include endocrine gl, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 30.8 CRH CYP11B1 CYP11B2 KCNJ5 MEN1 POMC
2 parathyroid transitional clear cell adenoma 10.9 MEN1 PTH
3 silent pituitary adenoma 10.9 AIP MEN1
4 null pituitary adenoma 10.9 AIP MEN1
5 bronchus adenoma 10.9 POMC SST
6 acute adrenal insufficiency 10.9 POMC REN
7 scleredema adultorum 10.9 POMC PTH
8 hypoaldosteronism 10.8 CYP11B2 POMC REN
9 pituitary apoplexy 10.8 AIP POMC PRL
10 galactorrhea 10.8 IGF1 PRL
11 pancreatic gastrinoma 10.8 MEN1 SST
12 tsh producing pituitary tumor 10.8 PRL SST
13 chiasmal syndrome 10.8 POMC PRL SST
14 mineral metabolism disease 10.7 POMC PTH REN
15 generalized resistance to thyroid hormone 10.7 PRL TRH
16 multiple endocrine neoplasia, type iv 10.7 AIP MEN1 PRL
17 adenohypophysitis 10.7 POMC PRL TRH
18 pancreatic somatostatinoma 10.7 MEN1 SST
19 steroid inherited metabolic disorder 10.7 CYP11B1 CYP11B2 POMC
20 carney complex variant 10.7 AIP MEN1 POMC
21 central nervous system organ benign neoplasm 10.7 IGF1 POMC PRL
22 inappropriate adh syndrome 10.7 POMC REN
23 adrenal rest tumor 10.7 CYP11B1 CYP11B2 POMC
24 postural hypotension 10.7 REN SST
25 growth hormone secreting pituitary adenoma 10.7 AIP PRL SST
26 acidophil adenoma 10.6 IGF1 POMC SST
27 pituitary hormone deficiency, combined, 2 10.6 IGF1 POMC PRL
28 hyperandrogenism 10.6 IGF1 POMC PRL
29 endocrine exophthalmos 10.6 POMC TG
30 acth-secreting pituitary adenoma 10.6 CRH POMC PRL
31 pseudohypoparathyroidism, type ia 10.6 IGF1 PRL TRH
32 adrenal cortical hypofunction 10.5 CRH POMC REN
33 pancreas disease 10.5 IGF1 POMC SST
34 mccune-albright syndrome 10.5 IGF1 PRL SST
35 fibrous dysplasia 10.5 IGF1 PRL SST
36 prolactin producing pituitary tumor 10.5 PRL SST
37 adrenocortical carcinoma, hereditary 10.5 CYP11B1 CYP11B2 POMC
38 apparent mineralocorticoid excess 10.5 NR3C2 POMC REN
39 lipoid congenital adrenal hyperplasia 10.5 CYP11B1 CYP11B2 POMC REN
40 substernal goiter 10.5 PTH TG
41 arthrogryposis, distal, type 3 10.5 NR3C2 REN
42 thyroid crisis 10.4 POMC PTH TG
43 pseudohyperkalemia, familial, 2, due to red cell leak 10.4 CYP11B2 NR3C2 REN
44 fasting hypoglycemia 10.4 CRH IGF1 POMC
45 craniopharyngioma 10.4 IGF1 PRL TRH
46 pituitary infarct 10.4 IGF1 POMC PRL SST
47 hyperparathyroidism 3 10.4 CDC73 MEN1
48 persistent fetal circulation syndrome 10.4 CRH IGF1 POMC
49 postsurgical hypothyroidism 10.4 PTH TG
50 glucose metabolism disease 10.4 IGF1 POMC REN SST

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:



Diseases related to Endocrine Organ Benign Neoplasm

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

GenomeRNAi Phenotypes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ATP1A1 ATP1A4 CYP11B1 IGF1 KCNJ5 MEN1

MGI Mouse Phenotypes related to Endocrine Organ Benign Neoplasm:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 CYP11B2 CDC73 AIP CRH ATP1A1 ATP1A4
2 growth/size/body region MP:0005378 10.39 CACNA1D CYP11B2 CDC73 AIP CRH ATP1A4
3 cardiovascular system MP:0005385 10.32 CYP11B1 CACNA1D CYP11B2 CDC73 AIP ATP1A1
4 endocrine/exocrine gland MP:0005379 10.32 CYP11B1 CACNA1D CYP11B2 CDC73 AIP CRH
5 cellular MP:0005384 10.24 CYP11B1 CACNA1D CDC73 AIP CRH ATP1A4
6 immune system MP:0005387 10.14 CDC73 CRH POMC PRL MEN1 CYP11B2
7 mortality/aging MP:0010768 10.1 CYP11B1 CACNA1D CDC73 AIP ATP1A1 IGF1
8 liver/biliary system MP:0005370 9.97 CDC73 AIP CRH POMC PRL MEN1
9 muscle MP:0005369 9.8 CYP11B1 CDC73 ATP1A1 IGF1 MEN1 NR3C2
10 nervous system MP:0003631 9.8 CACNA1D CYP11B2 CDC73 CRH PRL MEN1
11 neoplasm MP:0002006 9.63 CDC73 AIP IGF1 POMC PRL MEN1
12 renal/urinary system MP:0005367 9.23 CYP11B1 CYP11B2 CDC73 CRH NR3C2 IGF1

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

Genetic Tests for Endocrine Organ Benign Neoplasm

Anatomical Context for Endocrine Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

19
Endocrine Gl

Publications for Endocrine Organ Benign Neoplasm

Variations for Endocrine Organ Benign Neoplasm

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.3 ATP1A4 CACNA1D CRH KCNJ5
2
Show member pathways
12.22 AIP ATP1A1 ATP1A4 CACNA1D CRH CYP11B1
3 11.64 CRH CYP11B1 POMC
4 11.62 CRH GHRH POMC PTH
5
Show member pathways
11.6 CYP11B1 CYP11B2 POMC
6
Show member pathways
11.54 CYP11B2 NR3C2 REN
7 11.5 ATP1A1 ATP1A4 CACNA1D
8 11.29 ATP1A1 CACNA1D KCNJ5
9 11.08 ATP1A1 ATP1A4 CACNA1D
10 10.82 ATP1A1 ATP1A4 IGF1 NR3C2
11 10.25 CRH POMC
12 10.1 TG TRH

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 CRH GHRH IGF1 POMC PRL PTH
2 extracellular space GO:0005615 9.28 CRH GHRH IGF1 POMC PRL PTH
3 sodium:potassium-exchanging ATPase complex GO:0005890 9.16 ATP1A1 ATP1A4

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.93 GHRH POMC PTH SST TRH
2 response to drug GO:0042493 9.91 ATP1A1 CRH PTH REN SST
3 glucose homeostasis GO:0042593 9.81 CYP11B1 IGF1 POMC
4 response to nutrient levels GO:0031667 9.72 IGF1 PRL PTH
5 potassium ion import GO:0010107 9.67 ATP1A1 ATP1A4 KCNJ5
6 cellular sodium ion homeostasis GO:0006883 9.64 ATP1A1 ATP1A4
7 cardiac muscle cell action potential involved in contraction GO:0086002 9.63 ATP1A1 CACNA1D
8 positive regulation of glycogen biosynthetic process GO:0045725 9.62 IGF1 PTH
9 cellular potassium ion homeostasis GO:0030007 9.62 ATP1A1 ATP1A4
10 response to corticosterone GO:0051412 9.61 CRH TRH
11 sodium ion export across plasma membrane GO:0036376 9.61 ATP1A1 ATP1A4
12 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.6 ATP1A1 ATP1A4
13 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.59 GHRH IGF1
14 C21-steroid hormone biosynthetic process GO:0006700 9.58 CYP11B1 CYP11B2
15 small molecule metabolic process GO:0044281 9.58 CYP11B1 CYP11B2
16 cellular response to potassium ion GO:0035865 9.57 CYP11B1 CYP11B2
17 potassium ion import across plasma membrane GO:1990573 9.56 ATP1A1 KCNJ5
18 regulation of blood pressure GO:0008217 9.56 ATP1A1 CYP11B1 POMC REN
19 secondary metabolite biosynthetic process GO:0044550 9.52 CYP11B1 CYP11B2
20 cellular response to peptide hormone stimulus GO:0071375 9.5 CYP11B1 CYP11B2 MEN1
21 dehydroaustinol biosynthetic process GO:1900563 9.48 CYP11B1 CYP11B2
22 cortisol metabolic process GO:0034650 9.46 CYP11B1 CYP11B2
23 aldosterone biosynthetic process GO:0032342 9.43 CYP11B1 CYP11B2
24 austinol biosynthetic process GO:1900560 9.4 CYP11B1 CYP11B2
25 cortisol biosynthetic process GO:0034651 9.37 CYP11B1 CYP11B2
26 glucocorticoid biosynthetic process GO:0006704 9.33 CRH CYP11B1 CYP11B2
27 regulation of signaling receptor activity GO:0010469 9.23 GHRH IGF1 POMC PRL PTH SST
28 hormone-mediated apoptotic signaling pathway GO:0008628 9.13 CRH PTH SST

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 9.32 IGF1 REN
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP1A1 ATP1A4
3 hormone activity GO:0005179 9.23 CRH IGF1 POMC PRL PTH SST
4 corticosterone 18-monooxygenase activity GO:0047783 9.16 CYP11B1 CYP11B2
5 steroid 11-beta-monooxygenase activity GO:0004507 8.96 CYP11B1 CYP11B2

Sources for Endocrine Organ Benign Neoplasm

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11 DGIdb
17 ExPASy
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69 SNOMED-CT via HPO
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