MCID: END036
MIFTS: 22

Endocrine Organ Benign Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Endocrine Organ Benign Neoplasm

MalaCards integrated aliases for Endocrine Organ Benign Neoplasm:

Name: Endocrine Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060089

Summaries for Endocrine Organ Benign Neoplasm

Disease Ontology : 12 An organ system benign neoplasm that is located in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

MalaCards based summary : Endocrine Organ Benign Neoplasm is related to adrenal adenoma and pheochromocytoma. An important gene associated with Endocrine Organ Benign Neoplasm is MIR483 (MicroRNA 483), and among its related pathways/superpathways are MicroRNAs in cancer and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body.

Related Diseases for Endocrine Organ Benign Neoplasm

Diseases related to Endocrine Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 adrenal adenoma 33.1 REN POMC MIR483 MEN1
2 pheochromocytoma 32.7 SST SDHD SDHB RET REN PRL
3 bronchial adenomas/carcinoids childhood 10.8 SST POMC
4 multiple endocrine neoplasia 10.8 SDHB RET MEN1
5 neurofibromatosis 10.8 SDHD SDHB RET
6 parathyroid transitional clear cell adenoma 10.8 PTH MEN1
7 adenohypophysitis 10.8 PRL POMC
8 polymyositis 10.8 MIR221 MIR210 MIR21
9 sporadic pheochromocytoma/secreting paraganglioma 10.8 SDHD SDHB RET
10 acute adrenal insufficiency 10.8 REN POMC
11 neural crest tumor 10.8 SDHD SDHB
12 acidophil adenoma 10.8 SST PRL POMC
13 pheochromocytoma-paraganglioma 10.8 SDHD SDHB RET
14 pituitary-dependent cushing's disease 10.8 SST PRL POMC
15 acth-dependent cushing syndrome 10.7 PRL POMC
16 tuberculum sellae meningioma 10.7 PRL POMC
17 chiasmal syndrome 10.7 SST POMC
18 hypoaldosteronism 10.7 REN POMC
19 gastric leiomyosarcoma 10.7 SDHD SDHB PGLS
20 sella turcica neoplasm 10.7 PRL POMC
21 miyoshi muscular dystrophy 1 10.7 MIR221 MIR210 MIR21
22 nelson syndrome 10.7 SST PRL POMC
23 ectopic cushing syndrome 10.7 SST RET POMC
24 cerebellar angioblastoma 10.7 SDHD SDHB MEN1
25 steroid inherited metabolic disorder 10.7 REN PRL POMC
26 peripartum cardiomyopathy 10.7 PRL MIR210 MIR21
27 pituitary infarct 10.7 SST PRL POMC MEN1
28 prolactin producing pituitary tumor 10.7 PRL POMC
29 gastrointestinal neuroendocrine benign tumor 10.7 SST MEN1 CHGA
30 non-functioning pancreatic endocrine tumor 10.7 SST MEN1 CHGA
31 chromophobe adenoma 10.7 PRL POMC
32 cranial nerve palsy 10.7 SDHD PRL POMC PGLS
33 chondroma 10.7 SDHD SDHB PGLS
34 hormone producing pituitary cancer 10.7 SST PRL POMC MEN1
35 gastric neuroendocrine neoplasm 10.7 SST MEN1 CHGA
36 duodenal somatostatinoma 10.7 SST PGLS MEN1
37 pituitary apoplexy 10.7 SST PRL POMC MEN1
38 lipomatosis 10.7 SDHB MIR483 MEN1
39 duodenal gastrinoma 10.7 SST MEN1 CHGA
40 hyperpituitarism 10.7 SST PRL POMC MEN1
41 pituitary tumors 10.7 SST PRL POMC MEN1
42 pancreatic cholera 10.7 SST MEN1 CHGA
43 growth hormone secreting pituitary adenoma 10.7 SST PRL POMC MEN1
44 pancreatic gastrinoma 10.7 SST MEN1 CHGA
45 endocrine pancreas disease 10.7 SST MEN1 CHGA
46 skin lipoma 10.7 RET MEN1
47 somatostatinoma 10.7 SST MEN1 CHGA
48 gastrointestinal neuroendocrine tumor 10.7 SST MEN1 CHGA
49 hereditary paraganglioma-pheochromocytoma syndromes 10.7 SDHD SDHB RET
50 carcinoid tumors, intestinal 10.7 SST MEN1 CHGA

Graphical network of the top 20 diseases related to Endocrine Organ Benign Neoplasm:



Diseases related to Endocrine Organ Benign Neoplasm

Symptoms & Phenotypes for Endocrine Organ Benign Neoplasm

Drugs & Therapeutics for Endocrine Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Endocrine Organ Benign Neoplasm

Genetic Tests for Endocrine Organ Benign Neoplasm

Anatomical Context for Endocrine Organ Benign Neoplasm

The Foundational Model of Anatomy Ontology organs/tissues related to Endocrine Organ Benign Neoplasm:

19
Endocrine Glands Which Secretes A Type Of Hormone Directly Into The Bloodstream To Regulate The Body

Publications for Endocrine Organ Benign Neoplasm

Variations for Endocrine Organ Benign Neoplasm

Expression for Endocrine Organ Benign Neoplasm

Search GEO for disease gene expression data for Endocrine Organ Benign Neoplasm.

Pathways for Endocrine Organ Benign Neoplasm

Pathways related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 MIR483 MIR221 MIR210 MIR21 MIR126
2 11.47 SST RET NGF MIR210
3 11.03 MIR93 MIR221 MIR210
4 10.21 PRL MIR126

GO Terms for Endocrine Organ Benign Neoplasm

Cellular components related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.44 SST REN PTH PRL POMC NGF
2 extracellular vesicle GO:1903561 9.26 MIR93 MIR221 MIR21 MIR126
3 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.16 SDHD SDHB

Biological processes related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.73 RET MIR221 MIR21 MIR126
2 regulation of blood pressure GO:0008217 9.65 REN POMC CHGA
3 positive regulation of blood vessel endothelial cell migration GO:0043536 9.58 MIR221 MIR210 MIR126
4 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.46 MIR210 MIR21
5 miRNA mediated inhibition of translation GO:0035278 9.46 MIR483 MIR221 MIR210 MIR21
6 negative regulation of cell proliferation GO:0008285 9.43 SST NGF MIR93 MIR221 MIR21 MEN1
7 negative regulation of interleukin-21 biosynthetic process GO:0045391 9.37 MIR221 MIR21
8 negative regulation of interleukin-21 production GO:0032705 9.32 MIR221 MIR21
9 hormone-mediated apoptotic signaling pathway GO:0008628 9.26 SST PTH
10 gene silencing by miRNA GO:0035195 9.23 MIR93 MIR582 MIR483 MIR221 MIR210 MIR21

Molecular functions related to Endocrine Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 SST PTH PRL POMC
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR93 MIR582 MIR483 MIR221 MIR210 MIR21
3 ubiquinone binding GO:0048039 9.16 SDHD SDHB

Sources for Endocrine Organ Benign Neoplasm

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68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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