MCID: END038
MIFTS: 38

Endocrine Pancreas Disease

Categories: Endocrine diseases

Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease 12 15
Disorder of Endocrine Pancreas 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1428
ICD10 33 E16
ICD9CM 35 251

Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to mixed cell adenoma and secondary adrenal insufficiency. An important gene associated with Endocrine Pancreas Disease is INS (Insulin), and among its related pathways/superpathways are Developmental Biology and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include pancreas, lung and kidney, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 mixed cell adenoma 10.3 IGF1 IRS1
2 secondary adrenal insufficiency 10.3 IGF1 INS
3 lipodystrophy, familial partial, type 1 10.3 INS LEP
4 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.3 IGF1 INS
5 cardiomyopathy, dilated, 1o 10.2 ABCC8 KCNJ11
6 acidophil adenoma 10.2 IGF1 SST
7 obesity-hypoventilation syndrome 10.2 ADIPOQ LEP
8 idiopathic recurrent pericarditis 10.2 ADIPOQ LEP
9 pituitary infarct 10.2 IGF1 SST
10 acute insulin response 10.2 ABCC8 INS KCNJ11
11 hirata disease 10.2 ABCC8 INS
12 duodenal somatostatinoma 10.2 INS SST
13 thiamine-responsive megaloblastic anemia syndrome 10.2 ABCC8 INS KCNJ11
14 postural hypotension 10.2 INS SST
15 alstrom syndrome 10.2 INS KCNJ11 LEP
16 diabetes mellitus, transient neonatal, 1 10.2 ABCC8 INS KCNJ11
17 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.2 INS LEP SLC2A4
18 fetal macrosomia 10.2 IGF1 INS LEP
19 lipodystrophy, congenital generalized, type 1 10.2 ADIPOQ INS LEP
20 nonalcoholic steatohepatitis 10.2 ADIPOQ INS LEP
21 fatty liver disease, nonalcoholic 1 10.2 ADIPOQ INS LEP
22 prediabetes syndrome 10.2 ADIPOQ INS LEP
23 insulinomatosis and diabetes mellitus 10.2 ABCC8 INS SST
24 apnea, obstructive sleep 10.2 ADIPOQ INS LEP
25 acquired generalized lipodystrophy 10.2 ADIPOQ INS LEP
26 hormone producing pituitary cancer 10.2 IGF1 SST
27 central precocious puberty 10.2 IGF1 LEP
28 inherited metabolic disorder 10.2 ADIPOQ INS LEP
29 hyperpituitarism 10.2 IGF1 INS SST
30 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 10.2 ABCC8 KCNJ11
31 munchausen by proxy 10.2 ABCC8 GCK KCNJ11
32 endocrine organ benign neoplasm 10.2 IGF1 INS SST
33 pituitary gland disease 10.2 IGF1 INS SST
34 type 1 diabetes mellitus 7 10.2 IGFBP1 INS
35 maturity-onset diabetes of the young, type 14 10.2 ABCC8 GCK
36 cell type benign neoplasm 10.2 IGF1 INS SST
37 hyperinsulinemic hypoglycemia, familial, 6 10.2 HADH INS
38 complete generalized lipodystrophy 10.2 INS LEP
39 hyperproinsulinemia 10.2 IGFBP1 INS SHBG
40 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.2 ADIPOQ INS
41 nutritional deficiency disease 10.2 IGF1 IGFBP1 LEP
42 microvascular complications of diabetes 1 10.2 IGF1 INS SST
43 nonalcoholic fatty liver disease 10.1 ADIPOQ INS LEP
44 hyperprolactinemia 10.1 IGF1 SHBG SST
45 sleep apnea 10.1 ADIPOQ IGF1 INS LEP
46 anovulation 10.1 IGF1 INS LEP SHBG
47 turner syndrome 10.1 IGF1 IGFBP1 SHBG
48 maturity-onset diabetes of the young, type 13 10.1 ABCC8 GCK INS KCNJ11
49 pancreatic agenesis 10.1 ABCC8 GCK INS KCNJ11
50 monogenic diabetes 10.1 ABCC8 GCK INS KCNJ11

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:



Diseases related to Endocrine Pancreas Disease

Symptoms & Phenotypes for Endocrine Pancreas Disease

MGI Mouse Phenotypes related to Endocrine Pancreas Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.31 ADIPOQ AKT1 GCK GIP HADH IGF1
2 homeostasis/metabolism MP:0005376 10.31 ABCC8 ADIPOQ AKT1 GCK GIP HADH
3 adipose tissue MP:0005375 10.29 ADIPOQ AKT1 HADH IGF1 INS IRS1
4 cardiovascular system MP:0005385 10.24 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
5 endocrine/exocrine gland MP:0005379 10.23 ABCC8 ADIPOQ AKT1 GCK HADH IGF1
6 cellular MP:0005384 10.22 ADIPOQ AKT1 HADH IGF1 IGFBP1 INS
7 immune system MP:0005387 10.11 ADIPOQ AKT1 IGF1 IGFBP1 INS IRS1
8 liver/biliary system MP:0005370 10 ADIPOQ AKT1 GCK IGFBP1 INS IRS1
9 integument MP:0010771 9.97 ADIPOQ AKT1 IGF1 INS IRS2 KCNJ11
10 mortality/aging MP:0010768 9.97 ADIPOQ AKT1 GCK IGF1 INS IRS1
11 muscle MP:0005369 9.65 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
12 renal/urinary system MP:0005367 9.23 ADIPOQ GCK HADH IGF1 INS IRS2

Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
2 Antioxidants Not Applicable
3 Central Nervous System Depressants Not Applicable
4 Protective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
2 Glucose Tolerance, Meal Timing and MTNR1B Completed NCT03003936 Not Applicable
3 MTNR1B SNP*Food Timing Interaction on Glucose Control Recruiting NCT03036592 Not Applicable
4 Feasibility of Laryngeal Mask Airway Gastro on Patients Undergoing Endoscopic Retrograde Cholangiopancreatography for Pancreas and Bile Duct Disorders Not yet recruiting NCT03775681 Not Applicable

Search NIH Clinical Center for Endocrine Pancreas Disease

Genetic Tests for Endocrine Pancreas Disease

Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

41
Pancreas, Lung, Kidney, Liver, Heart, Ovary, Pituitary

Publications for Endocrine Pancreas Disease

Variations for Endocrine Pancreas Disease

Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 ADIPOQ AKT1 GCK INS IRS1 IRS2
2
Show member pathways
12.9 AKT1 GCK IGF1 INS IRS1 IRS2
3
Show member pathways
12.85 ADIPOQ HADH LEP LPL SLC2A4
4
Show member pathways
12.81 AKT1 IGF1 IRS1 IRS2 SLC2A4
5
Show member pathways
12.77 ADIPOQ AKT1 INS IRS1 IRS2 LEP
6
Show member pathways
12.76 AKT1 INS IRS1 IRS2 SLC2A4
7
Show member pathways
12.76 ABCC8 AKT1 GCK GIP INS KCNJ11
8
Show member pathways
12.53 AKT1 INS IRS1 IRS2 LPL SLC2A4
9 12.53 ADIPOQ AKT1 IGFBP1 INS IRS1 IRS2
10
Show member pathways
12.49 AKT1 GCK INS IRS1 IRS2 LEP
11
Show member pathways
12.44 AKT1 IGF1 INS IRS1
12
Show member pathways
12.39 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
13
Show member pathways
12.38 AKT1 IGF1 IGFBP1 IRS1 IRS2
14
Show member pathways
12.32 ABCC8 ADIPOQ INS KCNJ11
15
Show member pathways
12.22 AKT1 INS IRS1 IRS2 LEP SLC2A4
16
Show member pathways
12.21 GIP IGF1 INS LEP
17
Show member pathways
12.11 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
18
Show member pathways
12.05 AKT1 IGF1 INS IRS1 IRS2 SLC2A4
19 12.04 AKT1 INS IRS1 IRS2
20
Show member pathways
11.97 AKT1 INS IRS1 IRS2 SLC2A4
21 11.91 AKT1 IGF1 INS SERPINE1
22 11.89 IGF1 INS SERPINE1
23
Show member pathways
11.86 AKT1 GCK INS
24
Show member pathways
11.84 AKT1 IRS1 IRS2
25 11.73 ADIPOQ IGF1 INS IRS1 IRS2 LEP
26 11.72 ADIPOQ AKT1 IRS1 IRS2 LEP SLC2A4
27 11.7 AKT1 INS LPL
28 11.69 AKT1 GCK IGFBP1 LEP SERPINE1
29 11.65 AKT1 INS IRS1
30 11.63 AKT1 IRS1 IRS2
31 11.62 AKT1 INS IRS1 IRS2
32 11.57 AKT1 INS IRS1 LEP
33 11.52 ABCC8 AKT1 IRS1 IRS2 KCNJ11 LEP
34 11.45 AKT1 INS IRS1
35 11.38 IGF1 INS IRS1
36 11.34 ABCC8 AKT1 GCK HADH IGFBP1 INS
37 11.3 AKT1 IGF1 IRS1
38 11.26 AKT1 INS SLC2A4
39
Show member pathways
11.26 ABCC8 ADIPOQ AKT1 GCK INS IRS1
40 11.24 AKT1 IRS1 IRS2
41 11.06 ADIPOQ IRS1 IRS2 LEP SLC2A4
42 10.95 AKT1 SHBG
43 10.89 INS SLC2A4
44
Show member pathways
10.89 IRS1 SLC2A4

GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ADIPOQ GIP IGF1 IGFBP1 INS LEP
2 sarcolemma GO:0042383 9.43 ABCC8 KCNJ11 SLC2A4
3 extracellular region GO:0005576 9.32 ADIPOQ GIP IGF1 IGFBP1 INS LEP
4 inward rectifying potassium channel GO:0008282 9.16 ABCC8 KCNJ11

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.95 AKT1 GCK INS SLC2A4
2 response to drug GO:0042493 9.95 ABCC8 ADIPOQ GIP HADH KCNJ11 LPL
3 positive regulation of protein kinase B signaling GO:0051897 9.93 INS IRS1 IRS2 LEP
4 response to ethanol GO:0045471 9.87 ADIPOQ LEP SLC2A4
5 female pregnancy GO:0007565 9.86 ABCC8 GIP LEP
6 positive regulation of cold-induced thermogenesis GO:0120162 9.86 ADIPOQ HADH LEP
7 circadian rhythm GO:0007623 9.85 ADIPOQ LEP SERPINE1
8 positive regulation of cell growth GO:0030307 9.85 AKT1 IGFBP1 INS
9 response to glucose GO:0009749 9.85 ADIPOQ GIP IRS2 LPL
10 response to nutrient GO:0007584 9.84 ADIPOQ LEP SST
11 response to insulin GO:0032868 9.84 ABCC8 HADH IRS1 LEP
12 insulin receptor signaling pathway GO:0008286 9.83 AKT1 IGFBP1 INS IRS1 IRS2
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.82 IGF1 INS LEP
14 response to nutrient levels GO:0031667 9.82 ADIPOQ GIP LEP
15 response to heat GO:0009408 9.81 AKT1 IGF1 SST
16 fatty acid beta-oxidation GO:0006635 9.8 ADIPOQ HADH LEP
17 cellular response to insulin stimulus GO:0032869 9.8 ADIPOQ AKT1 GCK IRS1 IRS2 SLC2A4
18 glucose homeostasis GO:0042593 9.8 ADIPOQ AKT1 GCK INS IRS1 LEP
19 phosphatidylinositol-mediated signaling GO:0048015 9.79 IGF1 IRS1 IRS2
20 positive regulation of insulin secretion GO:0032024 9.79 GCK GIP IRS2
21 response to activity GO:0014823 9.78 ADIPOQ HADH LEP
22 activation of protein kinase B activity GO:0032148 9.77 AKT1 IGF1 INS
23 regulation of insulin secretion GO:0050796 9.77 ABCC8 GCK GIP KCNJ11 LEP
24 phosphatidylinositol 3-kinase signaling GO:0014065 9.76 AKT1 IGF1 IRS1
25 negative regulation of insulin secretion GO:0046676 9.76 ABCC8 HADH IRS1 KCNJ11
26 positive regulation of cellular protein metabolic process GO:0032270 9.74 ADIPOQ AKT1 INS
27 positive regulation of insulin receptor signaling pathway GO:0046628 9.73 INS IRS1 LEP
28 negative regulation of release of cytochrome c from mitochondria GO:0090201 9.7 AKT1 IGF1
29 cellular glucose homeostasis GO:0001678 9.7 ABCC8 GCK
30 negative regulation of gluconeogenesis GO:0045721 9.7 ADIPOQ GCK INS
31 positive regulation of lipid biosynthetic process GO:0046889 9.69 AKT1 INS
32 cellular response to peptide GO:1901653 9.69 AKT1 IRS2
33 negative regulation of wound healing GO:0061045 9.69 ABCC8 SERPINE1
34 insulin-like growth factor receptor signaling pathway GO:0048009 9.69 AKT1 IGF1 IRS1
35 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.68 AKT1 INS
36 response to acidic pH GO:0010447 9.67 GIP SST
37 positive regulation of glucose metabolic process GO:0010907 9.67 AKT1 IRS1 IRS2
38 cellular response to leptin stimulus GO:0044320 9.66 GCK LEP
39 positive regulation of fatty acid beta-oxidation GO:0032000 9.66 IRS1 IRS2
40 regulation of fatty acid biosynthetic process GO:0042304 9.65 ADIPOQ GIP
41 bone mineralization involved in bone maturation GO:0035630 9.63 IGF1 LEP
42 positive regulation of glucose import GO:0046326 9.63 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
43 negative regulation of plasma membrane long-chain fatty acid transport GO:0010748 9.6 AKT1 IRS2
44 glucose metabolic process GO:0006006 9.5 ADIPOQ AKT1 GCK INS IRS2 KCNJ11
45 positive regulation of glycogen biosynthetic process GO:0045725 9.1 AKT1 GCK IGF1 INS IRS1 IRS2
46 positive regulation of cell proliferation GO:0008284 10.05 AKT1 IGF1 INS IRS1 IRS2 LEP
47 regulation of signaling receptor activity GO:0010469 10.02 ADIPOQ GIP IGF1 INS LEP SERPINE1

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 ADIPOQ IGFBP1 LEP LPL SERPINE1
2 insulin-like growth factor receptor binding GO:0005159 9.33 IGF1 INS IRS1
3 ATP-activated inward rectifier potassium channel activity GO:0015272 9.26 ABCC8 KCNJ11
4 insulin receptor binding GO:0005158 9.26 IGF1 INS IRS1 IRS2
5 hormone activity GO:0005179 9.1 ADIPOQ GIP IGF1 INS LEP SST

Sources for Endocrine Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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