MCID: END038
MIFTS: 25

Endocrine Pancreas Disease

Categories: Endocrine diseases

Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease 12 15
Disorder of Endocrine Pancreas 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1428
ICD9CM 34 251
SNOMED-CT 67 190427005
ICD10 32 E16
UMLS 70 C0154189 C0271633

Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to jejunal somatostatinoma and neurogenic bowel. An important gene associated with Endocrine Pancreas Disease is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drug Melatonin has been mentioned in the context of this disorder. Affiliated tissues include pituitary, pancreas and thyroid.

Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 jejunal somatostatinoma 10.3 SST PPY
2 neurogenic bowel 10.3 VIP GAST
3 gastric antral vascular ectasia 10.2 SST GAST
4 abnormality of glucagon secretion 10.2 SST GCG
5 biliary dyskinesia 10.2 SST SCT
6 ampulla of vater benign neoplasm 10.2 SST CHGA
7 angular cheilitis 10.2 SST GCG
8 extracranial neuroblastoma 10.2 VIP CHGA
9 diamond-blackfan anemia 5 10.2 SST PPY
10 duodenal benign neoplasm 10.2 SST CHGA
11 cervical neuroblastoma 10.2 VIP CHGA
12 auditory system benign neoplasm 10.2 PPY CHGA
13 autoimmune atrophic gastritis 10.2 GAST CHGA
14 middle ear adenoma 10.2 PPY CHGA
15 gastric hemangioma 10.2 SST CHGA
16 volvulus of midgut 10.2 SST GCG
17 angiodysplasia 10.2 SST SCT
18 leprosy 2 10.2 VIP CALCA
19 sensory organ benign neoplasm 10.2 PPY CHGA
20 mixed ductal-endocrine carcinoma 10.2 GAST CHGA
21 bile reflux 10.2 SCT GAST
22 goblet cell carcinoid 10.2 GAST CHGA
23 cluster headache 10.2 VIP CALCA
24 cryptosporidiosis 10.2 VIP SST
25 adrenal medulla cancer 10.2 SST CHGA
26 rectum neuroendocrine neoplasm 10.1 VIP SST GAST
27 lactase deficiency, congenital 10.1 VIP SCT
28 secretory diarrhea 10.1 VIP SST
29 pituitary-dependent cushing's disease 10.1 SST GHRH
30 pancreatoblastoma 10.1 SST CHGA
31 hypertrophic pyloric stenosis 10.1 SST GAST
32 vasomotor rhinitis 10.1 VIP CALCA
33 barre-lieou syndrome 10.1 GCG CALCA
34 nasal cavity adenocarcinoma 10.1 GAST CALCA
35 duodenogastric reflux 10.1 SST SCT GAST
36 binswanger's disease 10.1 VIP SST CHGA
37 active peptic ulcer disease 10.1 SST HRH2
38 postgastrectomy syndrome 10.1 SST GCG GAST
39 ganglioneuroma 10.1 VIP SST CHGA
40 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1 HRH2 GAST
41 bile acid malabsorption, primary 10.1 SST SCT GCG
42 diabetic autonomic neuropathy 10.1 PPY GCG GAST
43 autonomic neuropathy 10.1 PPY GCG GAST
44 hernia, hiatus 10.1 HRH2 GAST
45 irritable bowel syndrome 10.1 VIP SST CHGA
46 appendix lymphoma 10.1 SST GAST CHGA
47 short bowel syndrome 10.1 SST GCG GAST
48 peptic esophagitis 10.1 HRH2 GAST
49 subependymal giant cell astrocytoma 10.0 SST CHGA
50 pancreatic somatostatinoma 10.0 SST PPY CALCA

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:



Diseases related to Endocrine Pancreas Disease

Symptoms & Phenotypes for Endocrine Pancreas Disease

Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
2 Glucose Tolerance, Meal Timing and MTNR1B in a Mediterranean Population Completed NCT03003936
3 MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population Recruiting NCT03036592

Search NIH Clinical Center for Endocrine Pancreas Disease

Genetic Tests for Endocrine Pancreas Disease

Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

40
Pituitary, Pancreas, Thyroid, Small Intestine, Colon, Liver, Lung

Publications for Endocrine Pancreas Disease

Variations for Endocrine Pancreas Disease

Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 VIP SST SCT PPY MEN1 HRH2
2
Show member pathways
13.04 VIP SST SCT PPY HRH2 GHRH
3
Show member pathways
12.14 SST SCT HRH2 GAST
4
Show member pathways
12.07 SCT GHRH GCG CALCA
5 11.94 VIP SST GCG
6 11.26 VIP SCT HRH2 GHRH GCG CALCA
7 10.02 HRH2 GAST
8 9.98 VIP SCT GAST

GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SST SCT PPY GHRH GCG GAST
2 extracellular region GO:0005576 9.28 VIP SST SCT PPY GHRH GCG

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.54 SST GHRH CALCA
2 feeding behavior GO:0007631 9.33 PPY GCG CALCA
3 response to food GO:0032094 9.32 GHRH GAST
4 G protein-coupled receptor signaling pathway GO:0007186 9.28 VIP SST SCT PPY HRH2 GHRH
5 positive regulation of blood vessel diameter GO:0097755 9.26 VIP CALCA
6 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 VIP GHRH GCG CALCA

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 VIP SST SCT PPY GHRH GCG
2 peptide hormone receptor binding GO:0051428 9.16 VIP GHRH
3 neuropeptide hormone activity GO:0005184 9.13 VIP PPY GHRH

Sources for Endocrine Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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