MCID: END038
MIFTS: 39

Endocrine Pancreas Disease

Categories: Endocrine diseases

Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease 12 15
Disorder of Endocrine Pancreas 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1428
ICD9CM 36 251
ICD10 34 E16

Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to mixed cell adenoma and secondary adrenal insufficiency. An important gene associated with Endocrine Pancreas Disease is INS (Insulin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Developmental Biology. The drugs Pancrelipase and Melatonin have been mentioned in the context of this disorder. Affiliated tissues include pancreas, liver and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 mixed cell adenoma 10.4 IGF1 IRS1
2 secondary adrenal insufficiency 10.4 IGF1 INS
3 acidophil adenoma 10.4 IGF1 SST
4 acute insulin response 10.4 ABCC8 INS KCNJ11
5 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.4 INS LEP SLC2A4
6 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.4 IGF1 INS
7 obesity-hypoventilation syndrome 10.3 ADIPOQ LEP
8 idiopathic recurrent pericarditis 10.3 ADIPOQ LEP
9 pituitary infarct 10.3 IGF1 SST
10 thiamine-responsive megaloblastic anemia syndrome 10.3 ABCC8 INS KCNJ11
11 fetal macrosomia 10.3 IGF1 INS LEP
12 alstrom syndrome 10.3 INS KCNJ11 LEP
13 cardiomyopathy, dilated, 1o 10.3 ABCC8 KCNJ11
14 diabetes mellitus, transient neonatal, 1 10.3 ABCC8 INS KCNJ11
15 lipodystrophy, congenital generalized, type 1 10.3 ADIPOQ INS LEP
16 nonalcoholic steatohepatitis 10.3 ADIPOQ INS LEP
17 insulinomatosis and diabetes mellitus 10.3 ABCC8 INS SST
18 fatty liver disease, nonalcoholic 1 10.3 ADIPOQ INS LEP
19 apnea, obstructive sleep 10.3 ADIPOQ INS LEP
20 munchausen by proxy 10.3 ABCC8 GCK KCNJ11
21 duodenal somatostatinoma 10.3 INS SST
22 hyperpituitarism 10.3 IGF1 INS SST
23 inherited metabolic disorder 10.3 ADIPOQ INS LEP
24 nonalcoholic fatty liver disease 10.3 ADIPOQ INS LEP
25 endocrine organ benign neoplasm 10.3 IGF1 INS SST
26 pituitary gland disease 10.3 IGF1 INS SST
27 cell type benign neoplasm 10.3 IGF1 INS SST
28 hyperproinsulinemia 10.2 IGFBP1 INS SHBG
29 hormone producing pituitary cancer 10.2 IGF1 SST
30 nutritional deficiency disease 10.2 IGF1 IGFBP1 LEP
31 hirata disease 10.2 ABCC8 INS
32 hyperprolactinemia 10.2 IGF1 SHBG SST
33 microvascular complications of diabetes 1 10.2 IGF1 INS SST
34 sleep apnea 10.2 ADIPOQ IGF1 INS LEP
35 anovulation 10.2 IGF1 INS LEP SHBG
36 maturity-onset diabetes of the young, type 13 10.2 ABCC8 GCK INS KCNJ11
37 pancreatic agenesis 10.2 ABCC8 GCK INS KCNJ11
38 monogenic diabetes 10.2 ABCC8 GCK INS KCNJ11
39 lipodystrophy, familial partial, type 1 10.2 INS LEP PPARG
40 complete generalized lipodystrophy 10.2 INS LEP PPARG
41 diabetes mellitus, permanent neonatal 10.2 ABCC8 GCK INS KCNJ11
42 maturity-onset diabetes of the young, type 14 10.2 ABCC8 GCK
43 neonatal diabetes mellitus 10.2 ABCC8 GCK INS KCNJ11
44 maturity-onset diabetes of the young, type 10 10.2 INS KCNJ11 PPARG
45 turner syndrome 10.2 IGF1 IGFBP1 SHBG
46 familial partial lipodystrophy 10.2 INS LEP PPARG
47 male reproductive organ cancer 10.2 AKT1 IGF1 SHBG
48 hyperthyroidism 10.2 INS LEP SHBG SST
49 male reproductive system disease 10.1 AKT1 IGF1 SHBG
50 microvascular complications of diabetes 5 10.1 IGF1 INS SERPINE1

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:



Diseases related to Endocrine Pancreas Disease

Symptoms & Phenotypes for Endocrine Pancreas Disease

GenomeRNAi Phenotypes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

27 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 IGFBP1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 IRS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.77 IRS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-128 9.77 IGFBP1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.77 IGFBP1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.77 IGFBP1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.77 AKT1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.77 IGFBP1 IRS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.77 IGFBP1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 AKT1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.77 GLUD1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.77 IRS2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 IRS2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.77 AKT1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.77 IRS2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.77 AKT1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.77 GLUD1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.77 GLUD1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.77 AKT1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.77 IRS2
21 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.77 AKT1 GLUD1 IGFBP1 IRS2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.77 GLUD1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 GLUD1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 AKT1

MGI Mouse Phenotypes related to Endocrine Pancreas Disease:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ABCC8 ADIPOQ AKT1 GCK GIP GLUD1
2 growth/size/body region MP:0005378 10.38 ADIPOQ AKT1 GCK GIP GLUD1 IGF1
3 adipose tissue MP:0005375 10.31 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
4 endocrine/exocrine gland MP:0005379 10.31 ABCC8 ADIPOQ AKT1 GCK GLUD1 IGF1
5 cardiovascular system MP:0005385 10.3 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
6 cellular MP:0005384 10.25 ADIPOQ AKT1 IGF1 IGFBP1 INS IRS1
7 immune system MP:0005387 10.21 ADIPOQ AKT1 IGF1 IGFBP1 INS IRS1
8 mortality/aging MP:0010768 10.17 ADIPOQ AKT1 GCK IGF1 INS IRS1
9 liver/biliary system MP:0005370 10.15 ADIPOQ AKT1 GCK IGFBP1 INS IRS1
10 integument MP:0010771 10.1 ADIPOQ AKT1 IGF1 INS IRS2 KCNJ11
11 muscle MP:0005369 10 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
12 nervous system MP:0003631 9.65 ADIPOQ AKT1 IGF1 INS IRS2 KCNJ11
13 neoplasm MP:0002006 9.63 ADIPOQ AKT1 IGF1 LEP PPARG SERPINE1
14 renal/urinary system MP:0005367 9.23 ADIPOQ GCK IGF1 INS IRS2 LEP

Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Not Applicable 53608-75-6
2
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
3 Antioxidants Not Applicable
4 Protective Agents Not Applicable
5 Central Nervous System Depressants Not Applicable
6 pancreatin Not Applicable
7 Anesthetics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
2 Glucose Tolerance, Meal Timing and MTNR1B Completed NCT03003936 Not Applicable
3 MTNR1B SNP*Food Timing Interaction on Glucose Control Recruiting NCT03036592 Not Applicable
4 Feasibility of Laryngeal Mask Airway Gastro on Patients Undergoing Endoscopic Retrograde Cholangiopancreatography for Pancreas and Bile Duct Disorders Recruiting NCT03775681 Not Applicable

Search NIH Clinical Center for Endocrine Pancreas Disease

Genetic Tests for Endocrine Pancreas Disease

Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

42
Pancreas, Liver, Pituitary, Kidney, Heart, Ovary, Prostate

Publications for Endocrine Pancreas Disease

Variations for Endocrine Pancreas Disease

Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 ADIPOQ AKT1 INS IRS1 IRS2 LEP
2
Show member pathways
13.49 ADIPOQ AKT1 GCK INS IRS1 IRS2
3
Show member pathways
12.95 ABCC8 AKT1 GCK GIP INS KCNJ11
4
Show member pathways
12.9 AKT1 GCK IGF1 INS IRS1 IRS2
5
Show member pathways
12.87 ADIPOQ LEP LPL PPARG SLC2A4
6
Show member pathways
12.83 AKT1 IGF1 IRS1 IRS2 SLC2A4
7
Show member pathways
12.83 AKT1 IGF1 INS IRS1 PPARG
8
Show member pathways
12.78 AKT1 INS IRS1 IRS2 SLC2A4
9
Show member pathways
12.77 ADIPOQ AKT1 INS IRS1 IRS2 LEP
10
Show member pathways
12.54 AKT1 INS IRS1 IRS2 LPL SLC2A4
11 12.51 ADIPOQ AKT1 GLUD1 IGFBP1 INS IRS1
12
Show member pathways
12.49 AKT1 GCK INS IRS1 IRS2 LEP
13
Show member pathways
12.46 AKT1 IGF1 INS IRS1
14
Show member pathways
12.39 AKT1 IGF1 IGFBP1 IRS1 IRS2
15
Show member pathways
12.39 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
16
Show member pathways
12.34 ABCC8 ADIPOQ INS KCNJ11
17
Show member pathways
12.29 AKT1 IGF1 IRS1 PPARG
19
Show member pathways
12.23 AKT1 IRS1 PPARG SERPINE1
20
Show member pathways
12.22 GIP IGF1 INS LEP
21
Show member pathways
12.22 AKT1 INS IRS1 IRS2 LEP SLC2A4
22
Show member pathways
12.18 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
23
Show member pathways
12.09 AKT1 IGF1 INS IRS1 IRS2 SLC2A4
24 12.05 AKT1 INS IRS1 IRS2
25
Show member pathways
11.98 AKT1 INS IRS1 IRS2 SLC2A4
26 11.92 AKT1 IGF1 INS SERPINE1
27 11.9 IGF1 INS SERPINE1
28
Show member pathways
11.87 AKT1 GCK INS
29
Show member pathways
11.86 AKT1 IRS1 IRS2
30 11.78 ADIPOQ IGF1 INS IRS1 IRS2 LEP
31 11.76 AKT1 INS LPL PPARG
32 11.75 ADIPOQ AKT1 IRS1 IRS2 LEP SLC2A4
33 11.73 ADIPOQ LPL PPARG
34 11.71 AKT1 GCK IGFBP1 LEP SERPINE1
35 11.66 AKT1 INS IRS1
36 11.63 AKT1 IRS1 IRS2
37 11.63 AKT1 INS IRS1 IRS2
38 11.57 AKT1 INS IRS1 LEP
39 11.52 ABCC8 AKT1 GCK IGFBP1 INS KCNJ11
40 11.46 AKT1 INS IRS1
41 11.42 ABCC8 AKT1 IRS1 IRS2 KCNJ11 LEP
42 11.39 IGF1 INS IRS1
43 11.31 AKT1 IGF1 IRS1
44 11.27 AKT1 INS SLC2A4
45
Show member pathways
11.26 ABCC8 ADIPOQ AKT1 GCK INS IRS1
46 11.25 AKT1 IRS1 IRS2
47 11.2 ADIPOQ LEP PPARG
48 11.08 ADIPOQ IRS1 IRS2 LEP PPARG SLC2A4
49 10.91 INS SLC2A4

GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 ADIPOQ GIP IGF1 IGFBP1 INS LEP
2 sarcolemma GO:0042383 9.43 ABCC8 KCNJ11 SLC2A4
3 extracellular region GO:0005576 9.32 ADIPOQ GIP IGF1 IGFBP1 INS LEP
4 inward rectifying potassium channel GO:0008282 9.16 ABCC8 KCNJ11

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 carbohydrate metabolic process GO:0005975 9.95 AKT1 GCK INS SLC2A4
2 response to drug GO:0042493 9.95 ABCC8 ADIPOQ GIP KCNJ11 LPL PPARG
3 positive regulation of protein kinase B signaling GO:0051897 9.92 INS IRS1 IRS2 LEP
4 response to nutrient GO:0007584 9.87 ADIPOQ LEP PPARG SST
5 cellular response to insulin stimulus GO:0032869 9.87 ADIPOQ AKT1 GCK IRS1 IRS2 PPARG
6 female pregnancy GO:0007565 9.86 ABCC8 GIP LEP
7 response to glucose GO:0009749 9.86 ADIPOQ GIP IRS2 LPL
8 circadian rhythm GO:0007623 9.85 ADIPOQ LEP SERPINE1
9 positive regulation of cell growth GO:0030307 9.85 AKT1 IGFBP1 INS
10 insulin receptor signaling pathway GO:0008286 9.83 AKT1 IGFBP1 INS IRS1 IRS2
11 response to insulin GO:0032868 9.82 ABCC8 IRS1 LEP
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.82 IGF1 INS LEP
13 response to nutrient levels GO:0031667 9.81 ADIPOQ GIP LEP
14 response to heat GO:0009408 9.8 AKT1 IGF1 SST
15 phosphatidylinositol-mediated signaling GO:0048015 9.79 IGF1 IRS1 IRS2
16 positive regulation of insulin secretion GO:0032024 9.78 GCK GIP GLUD1 IRS2
17 activation of protein kinase B activity GO:0032148 9.77 AKT1 IGF1 INS
18 regulation of insulin secretion GO:0050796 9.77 ABCC8 GCK GIP KCNJ11 LEP
19 phosphatidylinositol 3-kinase signaling GO:0014065 9.76 AKT1 IGF1 IRS1
20 negative regulation of insulin secretion GO:0046676 9.75 ABCC8 IRS1 KCNJ11
21 positive regulation of glucose import GO:0046326 9.73 ADIPOQ AKT1 IGF1 INS IRS1 IRS2
22 positive regulation of cellular protein metabolic process GO:0032270 9.72 ADIPOQ AKT1 INS
23 positive regulation of insulin receptor signaling pathway GO:0046628 9.71 INS IRS1 LEP
24 cellular response to prostaglandin E stimulus GO:0071380 9.7 AKT1 PPARG
25 positive regulation of lipid biosynthetic process GO:0046889 9.7 AKT1 INS
26 regulation of fat cell differentiation GO:0045598 9.7 LEP PPARG
27 negative regulation of gluconeogenesis GO:0045721 9.7 ADIPOQ GCK INS
28 glucose metabolic process GO:0006006 9.7 ADIPOQ AKT1 GCK INS IRS2 KCNJ11
29 fatty acid oxidation GO:0019395 9.69 ADIPOQ PPARG
30 cellular response to peptide GO:1901653 9.69 AKT1 IRS2
31 negative regulation of wound healing GO:0061045 9.69 ABCC8 SERPINE1
32 insulin-like growth factor receptor signaling pathway GO:0048009 9.69 AKT1 IGF1 IRS1
33 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.68 ADIPOQ PPARG
34 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 9.68 AKT1 INS
35 response to acidic pH GO:0010447 9.67 GIP SST
36 positive regulation of glucose metabolic process GO:0010907 9.67 AKT1 IRS1 IRS2
37 cellular response to leptin stimulus GO:0044320 9.66 GCK LEP
38 positive regulation of fatty acid beta-oxidation GO:0032000 9.66 IRS1 IRS2
39 regulation of fatty acid biosynthetic process GO:0042304 9.65 ADIPOQ GIP
40 negative regulation of acute inflammatory response GO:0002674 9.64 INS PPARG
41 bone mineralization involved in bone maturation GO:0035630 9.62 IGF1 LEP
42 negative regulation of plasma membrane long-chain fatty acid transport GO:0010748 9.61 AKT1 IRS2
43 glucose homeostasis GO:0042593 9.56 ADIPOQ AKT1 GCK INS IRS1 LEP
44 positive regulation of glycogen biosynthetic process GO:0045725 9.1 AKT1 GCK IGF1 INS IRS1 IRS2
45 signal transduction GO:0007165 10.27 AKT1 GIP IGF1 IGFBP1 IRS1 IRS2
46 positive regulation of cell proliferation GO:0008284 10.08 AKT1 IGF1 INS IRS1 IRS2 LEP
47 regulation of signaling receptor activity GO:0010469 10 ADIPOQ GIP IGF1 INS LEP SERPINE1

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 ADIPOQ IGFBP1 LEP LPL SERPINE1
2 insulin-like growth factor receptor binding GO:0005159 9.33 IGF1 INS IRS1
3 insulin receptor binding GO:0005158 9.26 IGF1 INS IRS1 IRS2
4 hormone activity GO:0005179 9.1 ADIPOQ GIP IGF1 INS LEP SST
5 ATP-activated inward rectifier potassium channel activity GO:0015272 8.96 KCNJ11
6 protein binding GO:0005515 10.27 ADIPOQ AKT1 GCK GIP GLUD1 IGF1

Sources for Endocrine Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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