MCID: END038
MIFTS: 36

Endocrine Pancreas Disease

Categories: Endocrine diseases

Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease 12 15
Disorder of Endocrine Pancreas 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1428
ICD10 33 E16
ICD9CM 35 251

Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to bronchus adenoma and secondary adrenal insufficiency. An important gene associated with Endocrine Pancreas Disease is INS (Insulin), and among its related pathways/superpathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. The drugs Melatonin and Antioxidants have been mentioned in the context of this disorder. Affiliated tissues include pancreas, and related phenotypes are Reduced mammosphere formation and growth/size/body region

Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 bronchus adenoma 11.0 POMC SST
2 secondary adrenal insufficiency 10.9 IGF1 INS
3 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.9 LEP POMC
4 scleredema adultorum 10.9 INS POMC
5 sheehan syndrome 10.8 IGF1 INS POMC
6 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.8 IGF1 INS
7 acidophil adenoma 10.8 IGF1 POMC SST
8 pituitary infarct 10.8 IGF1 POMC SST
9 pituitary-dependent cushing's disease 10.8 INS POMC SST
10 thyroid gland disease 10.7 IGF1 INS POMC
11 gonadal disease 10.7 IGF1 INS POMC
12 mixed cell adenoma 10.7 IGF1 IRS1
13 endocrine organ benign neoplasm 10.7 IGF1 POMC SST
14 hyperandrogenism 10.7 IGF1 INS POMC
15 pituitary tumors 10.7 IGF1 POMC SST
16 rubeosis iridis 10.7 IGF1 IGF2 INS
17 type 1 diabetes mellitus 2 10.7 IGF2 INS
18 islet cell tumor 10.7 IGF2 INS SST
19 anovulation 10.7 IGF1 INS LEP
20 postural hypotension 10.7 INS SST
21 hypopituitarism 10.7 IGF1 INS POMC
22 maturity-onset diabetes of the young, type 2 10.7 GCK INS
23 organ system benign neoplasm 10.7 IGF1 POMC SST
24 hypoglycemic coma 10.7 IGF2 INS
25 adrenal gland hyperfunction 10.7 LEP POMC SST
26 hyperprolactinemia 10.7 IGF1 POMC SST
27 postgastrectomy syndrome 10.7 GIP INS SST
28 pituitary adenoma, prolactin-secreting 10.7 IGF1 POMC SST
29 fanconi-bickel syndrome 10.7 ABCC8 G6PC INS
30 diabetes mellitus, transient neonatal, 1 10.6 ABCC8 INS KCNJ11
31 carbohydrate metabolic disorder 10.6 ABCC8 G6PC INS
32 alstrom syndrome 10.6 INS KCNJ11 LEP
33 chiasmal syndrome 10.6 POMC SST
34 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.6 INS LEP SLC2A4
35 lipodystrophy, familial partial, type 2 10.6 INS LEP
36 hyperpituitarism 10.6 IGF1 INS POMC SST
37 cardiomyopathy, dilated, 1o 10.6 ABCC8 KCNJ11
38 acquired generalized lipodystrophy 10.6 ADIPOQ LEP
39 pituitary gland disease 10.6 IGF1 INS POMC SST
40 hyperthyroidism 10.6 INS LEP SST
41 cell type benign neoplasm 10.6 IGF1 INS POMC SST
42 type 1 diabetes mellitus 15 10.5 GCG INS
43 hormone producing pituitary cancer 10.5 IGF1 SST
44 munchausen by proxy 10.5 ABCC8 GCK KCNJ11
45 fetal macrosomia 10.5 IGF1 IGF2 INS LEP
46 obesity-hypoventilation syndrome 10.5 ADIPOQ LEP
47 idiopathic recurrent pericarditis 10.5 ADIPOQ LEP
48 nonalcoholic steatohepatitis 10.5 ADIPOQ INS LEP
49 apnea, obstructive sleep 10.5 ADIPOQ INS LEP
50 fasting hypoglycemia 10.4 GLP1R IGF1 IGF2 POMC

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:



Diseases related to Endocrine Pancreas Disease

Symptoms & Phenotypes for Endocrine Pancreas Disease

GenomeRNAi Phenotypes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ABCC8 GLP1R IGF1 IGF2 KCNJ11 POMC

MGI Mouse Phenotypes related to Endocrine Pancreas Disease:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.36 ADIPOQ GLP1R IGF1 DPP4 G6PC IGF2
2 homeostasis/metabolism MP:0005376 10.33 ADIPOQ GLP1R IGF1 DPP4 G6PC IGF2
3 endocrine/exocrine gland MP:0005379 10.27 ADIPOQ GLP1R IGF1 DPP4 IGF2 GCK
4 behavior/neurological MP:0005386 10.24 GLP1R ADIPOQ G6PC IGF2 SLC5A2 SST
5 adipose tissue MP:0005375 10.21 ADIPOQ GLP1R IGF1 SLC5A2 SLC2A4 INS
6 cardiovascular system MP:0005385 10.13 ADIPOQ IGF1 SLC2A4 INS LEP IRS1
7 mortality/aging MP:0010768 10.1 ADIPOQ IGF1 G6PC IGF2 GCK SLC2A4
8 liver/biliary system MP:0005370 10.02 ADIPOQ G6PC IGF2 GCK SLC2A4 INS
9 muscle MP:0005369 9.86 ADIPOQ IGF1 IGF2 SLC2A4 INS LEP
10 no phenotypic analysis MP:0003012 9.7 IGF2 ABCC8 SLC5A2 SST INS POMC
11 renal/urinary system MP:0005367 9.61 ADIPOQ IGF1 G6PC IGF2 GCK SLC5A2
12 skeleton MP:0005390 9.32 ADIPOQ IGF1 G6PC IGF2 SLC5A2 SST

Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
2 Antioxidants Not Applicable
3 Central Nervous System Depressants Not Applicable
4 Protective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
2 Glucose Tolerance, Meal Timing and MTNR1B Completed NCT03003936 Not Applicable
3 MTNR1B SNP*Food Timing Interaction on Glucose Control Recruiting NCT03036592 Not Applicable

Search NIH Clinical Center for Endocrine Pancreas Disease

Genetic Tests for Endocrine Pancreas Disease

Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

41
Pancreas

Publications for Endocrine Pancreas Disease

Variations for Endocrine Pancreas Disease

Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 ABCC8 ADIPOQ G6PC GCG GCK GLP1R
2
Show member pathways
13.29 ABCC8 G6PC GCK KCNJ11 SLC2A4 SLC5A2
3
Show member pathways
12.96 ABCC8 GCG GCK GIP GLP1R INS
4
Show member pathways
12.82 ADIPOQ INS IRS1 LEP SLC2A4
5
Show member pathways
12.82 G6PC GCK IGF1 INS IRS1 SLC2A4
6
Show member pathways
12.77 G6PC GCK SLC2A4 SLC5A2 SLC5A4
7 12.5 ADIPOQ GCG INS IRS1 SLC2A4 SLC5A2
8
Show member pathways
12.43 G6PC INS IRS1 SLC2A4
9
Show member pathways
12.38 GCK INS IRS1 LEP
10
Show member pathways
12.36 ADIPOQ G6PC IGF1 INS IRS1 LEP
11
Show member pathways
12.32 ABCC8 ADIPOQ GCG GLP1R INS KCNJ11
12
Show member pathways
12.13 INS IRS1 LEP SLC2A4
13
Show member pathways
12.06 ADIPOQ IGF1 INS IRS1
14
Show member pathways
12.05 G6PC IGF1 INS IRS1 SLC2A4
15 12.04 GCG GIP GLP1R POMC
16 11.97 ADIPOQ IGF1 INS IRS1 LEP SLC2A4
17
Show member pathways
11.96 DPP4 GCG GIP IGF1 INS LEP
18
Show member pathways
11.89 G6PC INS IRS1 SLC2A4
19
Show member pathways
11.85 G6PC GCK SLC2A4 SLC5A2 SLC5A4
20 11.82 G6PC GCG GCK
21
Show member pathways
11.57 DPP4 GCG GIP LEP
22 11.51 IGF1 IGF2 INS
23 11.47 INS IRS1 LEP
24 11.44 ABCC8 IRS1 KCNJ11 LEP SLC2A4
25 11.3 IGF1 INS IRS1
26 11.3 ABCC8 G6PC GCK INS KCNJ11
27 11.27 ADIPOQ G6PC IRS1 LEP POMC SLC2A4
28
Show member pathways
11.15 ABCC8 ADIPOQ GCK INS IRS1 KCNJ11
29 11.08 ADIPOQ IRS1 LEP SLC2A4
30 10.85 INS SLC2A4
31
Show member pathways
10.84 IRS1 SLC2A4

GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 ADIPOQ DPP4 GCG GIP IGF1 IGF2
2 sarcolemma GO:0042383 9.5 ABCC8 KCNJ11 SLC2A4
3 secretory granule lumen GO:0034774 9.46 GCG GIP INS POMC
4 extracellular space GO:0005615 9.32 ADIPOQ GCG GIP IGF1 IGF2 INS
5 inward rectifying potassium channel GO:0008282 9.26 ABCC8 KCNJ11

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.98 ABCC8 ADIPOQ GIP KCNJ11 SST
2 carbohydrate metabolic process GO:0005975 9.96 GCK IGF2 INS SLC2A4 SLC5A2
3 regulation of gene expression GO:0010468 9.94 G6PC IGF1 IGF2 INS
4 positive regulation of protein kinase B signaling GO:0051897 9.9 IGF2 INS IRS1 LEP
5 positive regulation of MAPK cascade GO:0043410 9.89 IGF1 IGF2 INS LEP
6 glucose metabolic process GO:0006006 9.88 ADIPOQ GCK IGF2 INS KCNJ11 LEP
7 cellular response to insulin stimulus GO:0032869 9.85 ADIPOQ GCK IRS1 SLC2A4
8 response to glucose GO:0009749 9.85 ADIPOQ GIP IGF1 IGF2 INS
9 response to nutrient levels GO:0031667 9.85 ADIPOQ GIP IGF1 IGF2 INS LEP
10 regulation of signaling receptor activity GO:0010469 9.85 ADIPOQ GCG GIP IGF1 IGF2 INS
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 ADIPOQ IGF1 IGF2 INS
12 response to organic substance GO:0010033 9.83 IGF1 IGF2 INS
13 response to insulin GO:0032868 9.83 IGF1 IGF2 INS IRS1 LEP
14 insulin receptor signaling pathway GO:0008286 9.82 IGF2 INS IRS1
15 response to nutrient GO:0007584 9.81 ADIPOQ LEP SST
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 IGF1 IGF2 INS LEP
17 positive regulation of glucose import GO:0046326 9.78 ADIPOQ IGF1 INS IRS1
18 positive regulation of mitotic nuclear division GO:0045840 9.74 IGF1 IGF2 INS
19 positive regulation of insulin receptor signaling pathway GO:0046628 9.72 IGF1 IGF2 INS IRS1 LEP
20 glucose transmembrane transport GO:1904659 9.7 SLC2A4 SLC5A2 SLC5A4
21 positive regulation of cellular protein metabolic process GO:0032270 9.67 ADIPOQ INS
22 negative regulation of gluconeogenesis GO:0045721 9.67 ADIPOQ GCK INS
23 insulin-like growth factor receptor signaling pathway GO:0048009 9.65 IGF1 IRS1
24 response to acidic pH GO:0010447 9.65 GIP SST
25 positive regulation of glycogen biosynthetic process GO:0045725 9.65 GCK IGF1 IGF2 INS IRS1
26 regulation of appetite GO:0032098 9.63 POMC PPY
27 glucose 6-phosphate metabolic process GO:0051156 9.63 G6PC GCK
28 cellular response to leptin stimulus GO:0044320 9.62 GCK LEP
29 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
30 positive regulation of glycogen (starch) synthase activity GO:2000467 9.61 ADIPOQ IGF2
31 regulation of insulin secretion GO:0050796 9.56 ABCC8 DPP4 GCG GCK GIP GLP1R
32 glucose homeostasis GO:0042593 9.32 ADIPOQ G6PC GCK IGF1 IGF2 INS
33 G-protein coupled receptor signaling pathway GO:0007186 10.16 GCG GIP GLP1R INS POMC PPY
34 negative regulation of apoptotic process GO:0043066 10.06 GCG IGF1 IGF2 INS LEP
35 positive regulation of cell proliferation GO:0008284 10.05 DPP4 IGF1 IGF2 INS IRS1 LEP

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.8 ADIPOQ DPP4 GCG LEP POMC
2 insulin receptor binding GO:0005158 9.46 IGF1 IGF2 INS IRS1
3 receptor activator activity GO:0030546 9.43 IGF1 IGF2 INS
4 glucose:sodium symporter activity GO:0005412 9.37 SLC5A2 SLC5A4
5 ATP-activated inward rectifier potassium channel activity GO:0015272 9.32 ABCC8 KCNJ11
6 hormone activity GO:0005179 9.32 ADIPOQ GCG GIP IGF1 IGF2 INS
7 insulin-like growth factor receptor binding GO:0005159 9.26 IGF1 IGF2 INS IRS1

Sources for Endocrine Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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