MCID: END038
MIFTS: 23

Endocrine Pancreas Disease

Categories: Endocrine diseases

Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease 12 15
Disorder of Endocrine Pancreas 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1428
ICD9CM 34 251
ICD10 32 E16
UMLS 71 C0154189 C0271633

Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to jejunal somatostatinoma and gastric antral vascular ectasia. An important gene associated with Endocrine Pancreas Disease is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drug Melatonin has been mentioned in the context of this disorder. Affiliated tissues include pancreas.

Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 jejunal somatostatinoma 10.4 SST PPY
2 gastric antral vascular ectasia 10.3 SST GAST
3 abnormality of glucagon secretion 10.3 SST GCG
4 biliary dyskinesia 10.3 SST SCT
5 petrositis 10.3 SST GCG
6 pancreas, annular 10.3 SCT PPY
7 duodenal benign neoplasm 10.3 SST CHGA
8 ampulla of vater neoplasm 10.3 SST CHGA
9 angiodysplasia 10.3 SST SCT
10 autoimmune atrophic gastritis 10.3 GAST CHGA
11 auditory system benign neoplasm 10.3 PPY CHGA
12 angular cheilitis 10.3 SST GCG
13 bile reflux 10.3 SCT GAST
14 cervical neuroblastoma 10.3 VIP CHGA
15 middle ear adenoma 10.2 PPY CHGA
16 pituitary apoplexy 10.2 SST MEN1
17 gastric hemangioma 10.2 SST CHGA
18 mixed ductal-endocrine carcinoma 10.2 GAST CHGA
19 extracranial neuroblastoma 10.2 VIP CHGA
20 goblet cell carcinoid 10.2 GAST CHGA
21 sensory organ benign neoplasm 10.2 PPY CHGA
22 anal neuroendocrine tumor 10.2 SST SPINK5
23 rectum neuroendocrine neoplasm 10.2 VIP SST GAST
24 acth-secreting pituitary adenoma 10.2 SST MEN1
25 cryptosporidiosis 10.2 VIP SST
26 tricuspid valve stenosis 10.2 SST SPINK5
27 pituitary tumors 10.2 SST MEN1
28 adrenal medulla cancer 10.2 SST CHGA
29 peptic ulcer perforation 10.2 HRH2 GAST
30 secretory diarrhea 10.2 VIP SST
31 hypertrophic pyloric stenosis 10.2 SST GAST
32 pancreatoblastoma 10.2 SST CHGA
33 active peptic ulcer disease 10.2 SST HRH2
34 duodenogastric reflux 10.1 SST SCT GAST
35 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.1 HRH2 GAST
36 hernia, hiatus 10.1 HRH2 GAST
37 binswanger's disease 10.1 VIP SST CHGA
38 postgastrectomy syndrome 10.1 SST GCG GAST
39 pituitary-dependent cushing's disease 10.1 SST GHRH
40 persistent generalized lymphadenopathy 10.1 MEN1 CHGA
41 esophageal neuroendocrine tumor 10.1 SPINK5 CHGA
42 ganglioneuroma 10.1 VIP SST CHGA
43 bile acid malabsorption, primary 10.1 SST SCT GCG
44 diabetic autonomic neuropathy 10.1 PPY GCG GAST
45 autonomic neuropathy 10.1 PPY GCG GAST
46 appendix lymphoma 10.1 SST GAST CHGA
47 gallbladder small cell carcinoma 10.1 SPINK5 CHGA
48 appendiceal neoplasm 10.1 SPINK5 CHGA
49 pituitary adenoma 1, multiple types 10.1 SST MEN1
50 hyperinsulinemic hypoglycemia 10.0 SST MEN1 GCG

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:



Diseases related to Endocrine Pancreas Disease

Symptoms & Phenotypes for Endocrine Pancreas Disease

Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy Recruiting NCT02872571 Phase 1, Phase 2 Intramuscular Islet Autograft
2 Glucose Tolerance, Meal Timing and MTNR1B in a Mediterranean Population Completed NCT03003936
3 MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population Recruiting NCT03036592

Search NIH Clinical Center for Endocrine Pancreas Disease

Genetic Tests for Endocrine Pancreas Disease

Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

40
Pancreas

Publications for Endocrine Pancreas Disease

Variations for Endocrine Pancreas Disease

Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 VIP SST SCT PPY MEN1 HRH2
2
Show member pathways
13.04 VIP SST SCT PPY HRH2 GHRH
3
Show member pathways
12.07 SCT GHRH GCG CALCA
4 11.94 VIP SST GCG
5
Show member pathways
11.8 SST HRH2 GAST
6 11.26 VIP SCT HRH2 GHRH GCG CALCA
7 9.98 VIP SCT GAST
8 9.96 HRH2 GAST

GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SST SCT PPY GHRH GCG GAST
2 extracellular region GO:0005576 9.32 VIP SST SPINK5 SCT PPY GHRH

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 feeding behavior GO:0007631 9.33 PPY GCG CALCA
2 positive regulation of blood vessel diameter GO:0097755 9.32 VIP CALCA
3 G protein-coupled receptor signaling pathway GO:0007186 9.28 VIP SST SCT PPY HRH2 GHRH
4 response to food GO:0032094 9.26 GHRH GAST
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.26 VIP GHRH GCG CALCA

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.23 VIP SST SCT PPY GHRH GCG
2 peptide hormone receptor binding GO:0051428 9.16 VIP GHRH
3 neuropeptide hormone activity GO:0005184 9.13 VIP PPY GHRH

Sources for Endocrine Pancreas Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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