Endocrine Pancreas Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endocrine Pancreas Disease

MalaCards integrated aliases for Endocrine Pancreas Disease:

Name: Endocrine Pancreas Disease ¹² ¹⁵

Disorder of Endocrine Pancreas ⁷¹

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Other disorders of glucose regulation and pancreatic internal secretion

Other disorders of pancreatic internal secretion

External Ids:

Disease Ontology ¹² DOID:1428

ICD9CM ³⁴ 251

ICD10 ³² E16

UMLS ⁷¹ C0154189 C0271633

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Summaries for Endocrine Pancreas Disease

MalaCards based summary : Endocrine Pancreas Disease, also known as disorder of endocrine pancreas, is related to jejunal somatostatinoma and gastric antral vascular ectasia. An important gene associated with Endocrine Pancreas Disease is VIP (Vasoactive Intestinal Peptide), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drug Melatonin has been mentioned in the context of this disorder. Affiliated tissues include pancreas.

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Related Diseases for Endocrine Pancreas Disease

Diseases related to Endocrine Pancreas Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)

#	Related Disease	Score	Top Affiliating Genes
1	jejunal somatostatinoma	10.4	SST PPY
2	gastric antral vascular ectasia	10.3	SST GAST
3	abnormality of glucagon secretion	10.3	SST GCG
4	biliary dyskinesia	10.3	SST SCT
5	petrositis	10.3	SST GCG
6	pancreas, annular	10.3	SCT PPY
7	duodenal benign neoplasm	10.3	SST CHGA
8	ampulla of vater neoplasm	10.3	SST CHGA
9	angiodysplasia	10.3	SST SCT
10	autoimmune atrophic gastritis	10.3	GAST CHGA
11	auditory system benign neoplasm	10.3	PPY CHGA
12	angular cheilitis	10.3	SST GCG
13	bile reflux	10.3	SCT GAST
14	cervical neuroblastoma	10.3	VIP CHGA
15	middle ear adenoma	10.2	PPY CHGA
16	pituitary apoplexy	10.2	SST MEN1
17	gastric hemangioma	10.2	SST CHGA
18	mixed ductal-endocrine carcinoma	10.2	GAST CHGA
19	extracranial neuroblastoma	10.2	VIP CHGA
20	goblet cell carcinoid	10.2	GAST CHGA
21	sensory organ benign neoplasm	10.2	PPY CHGA
22	anal neuroendocrine tumor	10.2	SST SPINK5
23	rectum neuroendocrine neoplasm	10.2	VIP SST GAST
24	acth-secreting pituitary adenoma	10.2	SST MEN1
25	cryptosporidiosis	10.2	VIP SST
26	tricuspid valve stenosis	10.2	SST SPINK5
27	pituitary tumors	10.2	SST MEN1
28	adrenal medulla cancer	10.2	SST CHGA
29	peptic ulcer perforation	10.2	HRH2 GAST
30	secretory diarrhea	10.2	VIP SST
31	hypertrophic pyloric stenosis	10.2	SST GAST
32	pancreatoblastoma	10.2	SST CHGA
33	active peptic ulcer disease	10.2	SST HRH2
34	duodenogastric reflux	10.1	SST SCT GAST
35	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.1	HRH2 GAST
36	hernia, hiatus	10.1	HRH2 GAST
37	binswanger's disease	10.1	VIP SST CHGA
38	postgastrectomy syndrome	10.1	SST GCG GAST
39	pituitary-dependent cushing's disease	10.1	SST GHRH
40	persistent generalized lymphadenopathy	10.1	MEN1 CHGA
41	esophageal neuroendocrine tumor	10.1	SPINK5 CHGA
42	ganglioneuroma	10.1	VIP SST CHGA
43	bile acid malabsorption, primary	10.1	SST SCT GCG
44	diabetic autonomic neuropathy	10.1	PPY GCG GAST
45	autonomic neuropathy	10.1	PPY GCG GAST
46	appendix lymphoma	10.1	SST GAST CHGA
47	gallbladder small cell carcinoma	10.1	SPINK5 CHGA
48	appendiceal neoplasm	10.1	SPINK5 CHGA
49	pituitary adenoma 1, multiple types	10.1	SST MEN1
50	hyperinsulinemic hypoglycemia	10.0	SST MEN1 GCG

Graphical network of the top 20 diseases related to Endocrine Pancreas Disease:

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Symptoms & Phenotypes for Endocrine Pancreas Disease

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Drugs & Therapeutics for Endocrine Pancreas Disease

Drugs for Endocrine Pancreas Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Melatonin

Approved, Nutraceutical, Vet_approved

73-31-4

896

Synonyms:

{N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-} acetamide

{N-[2-(5-methoxyindol-3-yl)ethyl]-} acetamide

0E2B08C1-B325-45B1-8939-6F9081EFDFA4

4-ACETAMIDO-4'-ISOTHIO-CYANATOSTILBENE-2,2'-DISULFONIC ACID

5-22-12-00042 (Beilstein Handbook Reference)

5-methoxy-N-acetyltryptamine

5-Methoxy-N-acetyltryptamine

73-31-4

A4039/0172195

AB00053279

AC1L1A9Q

AC1Q4F1W

AC1Q4F1X

Acetamide, {N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-}

Acetamide, {N-[2-(5-methoxyindol-3-yl)ethyl]-}

Acetamide, N-(2-(5-methoxy-1H-indol-3-yl)ethyl)- (9CI)

Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]- (9CI)

Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]- (6CI,8CI)

AKOS000276269

BAS 01281092

BIDD:ER0618

Bio-0635

BPBio1_000590

BRD-K97530723-001-07-6

BRN 0205542

BSPBio_000536

BSPBio_003006

C01598

CAS-73-31-4

CCRIS 3472

CHEBI:16796

CHEMBL45

ChemDiv2_003916

CID896

Circadin

D008550

D08170

DB01065

DB08189

DivK1c_000353

EINECS 200-797-7

EU-0100787

HMS1380B22

HMS1569K18

HMS1921E04

HMS2089F09

HMS501B15

HSCI1_000400

HSDB 7509

I05-0076

I10-0345

IDI1_000353

IDI1_002631

IN1244

KBio1_000353

KBio2_000665

KBio2_003233

KBio2_005801

KBio3_002226

KBioGR_000591

KBioSS_000665

L001261

Lopac0_000787

Lopac-M-5250

LS-1623

M 5250

M1105

M-1200

M-1250

M5250_SIGMA

Melapure

Mela-T

Melatol

Melatonex

Melatonex, Melatonin

Melatonin

Melatonin (synth.) standard-grade

Melatonin (synth.) ultra-pure

Melatonina

Melatonina (TN)

Melatonine

Mélatonine

Melovine

ML1

MLS000859594

MLS001055382

MLS001240204

MolPort-000-737-883

MT6

N-(2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide

N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide

N-(2-(5-Methoxyindol-3-yl)ethyl)-acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl)acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-acetamide

N-[2-(5-Methoxy-1H-indol-3-yl)-ethyl]-acetamide

N-[2-(5-methoxyindol-3-yl)ethyl]acetamide

N-[2-(5-Methoxyindol-3-yl)ethyl]acetamide

N-[2-(5-Methoxyindol-3-yl)ethyl]-acetamide

N-acetyl-5-methoxy-tryptamine

N-Acetyl-5-methoxytryptamine

N-Acetyl-5-methoxy-tryptamine

N-Acetyl-5-methoxy-tryptamine melatonine

Nature'S Harmony

NCGC00015680-01

NCGC00015680-02

NCGC00015680-03

NCGC00015680-06

NCGC00015680-13

NCGC00090727-01

NCGC00090727-02

NCGC00090727-03

NCGC00090727-04

NCGC00090727-05

NCGC00090727-06

NCGC00090727-07

NCGC00090727-08

NCGC00090727-09

NCI60_004378

Night Rest

NINDS_000353

NMR/14327425

NSC 113928

NSC113928

NSC56423

Oprea1_104553

Oprea1_814234

Pineal Hormone

Posidorm

Prestwick_312

Prestwick0_000458

Prestwick1_000458

Prestwick2_000458

Prestwick3_000458

PREVENTION 1 (MELATONIN) (PREVENTION 1)

PREVENTION 2 (MELATONIN)

PREVENTION 3 (MELATONIN)

PREVENTION 4 (MELATONIN)

PREVENTION 5 (MELATONIN)

Regulin

Revital Melatonin

Rx Balance

S1204_Selleck

SDCCGMLS-0065812.P001

SDCCGMLS-0065812.P002

Sleep Right

SMP2_000309

SMR000326666

SPBio_001527

SPBio_002475

Spectrum_000185

SPECTRUM1500690

Spectrum2_001344

Spectrum3_001393

Spectrum4_000066

Spectrum5_001745

STK386880

TNP00300

UNII-JL5DK93RCL

Vivitas

WLN: T56 BMJ D2MV1 GO1

ZINC00057060

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Evaluation of the Efficacy of Intramuscular Islet Autograft After Extensive Pancreatectomy	Recruiting	NCT02872571	Phase 1, Phase 2	Intramuscular Islet Autograft
2	Glucose Tolerance, Meal Timing and MTNR1B in a Mediterranean Population	Completed	NCT03003936
3	MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population	Recruiting	NCT03036592

Search NIH Clinical Center for Endocrine Pancreas Disease

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Genetic Tests for Endocrine Pancreas Disease

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Anatomical Context for Endocrine Pancreas Disease

MalaCards organs/tissues related to Endocrine Pancreas Disease:

⁴⁰

Pancreas

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Publications for Endocrine Pancreas Disease

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Genes for Endocrine Pancreas Disease

Genes related to Endocrine Pancreas Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	VIP	Vasoactive Intestinal Peptide	Protein Coding	7.87	DISEASES inferred ¹⁵
2	SST	Somatostatin	Protein Coding	7.22	DISEASES inferred ¹⁵
3	PPY	Pancreatic Polypeptide	Protein Coding	6.87	DISEASES inferred ¹⁵
4	GAST	Gastrin	Protein Coding	6.86	DISEASES inferred ¹⁵
5	SCT	Secretin	Protein Coding	6.6	DISEASES inferred ¹⁵
6	MEN1	Menin 1	Protein Coding	6.08	DISEASES inferred ¹⁵
7	GCG	Glucagon	Protein Coding	6.04	DISEASES inferred ¹⁵
8	CHGA	Chromogranin A	Protein Coding	5.88	DISEASES inferred ¹⁵
9	HRH2	Histamine Receptor H2	Protein Coding	5.75	DISEASES inferred ¹⁵
10	GHRH	Growth Hormone Releasing Hormone	Protein Coding	5.71	DISEASES inferred ¹⁵
11	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	5.59	DISEASES inferred ¹⁵
12	SPINK5	Serine Peptidase Inhibitor Kazal Type 5	Protein Coding	5.53	DISEASES inferred ¹⁵

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Variations for Endocrine Pancreas Disease

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Expression for Endocrine Pancreas Disease

Search GEO for disease gene expression data for Endocrine Pancreas Disease.

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Pathways for Endocrine Pancreas Disease

Pathways related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	13.72	VIP SST SCT PPY MEN1 HRH2
2	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	13.04	VIP SST SCT PPY HRH2 GHRH
3	Presynaptic function of Kainate receptors ⁶⁵ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁵ Activation of Kainate Receptors upon glutamate binding ⁶⁵ Activation of Na-permeable Kainate Receptors ⁶⁵ Calcitonin-like ligand receptors ⁶⁵ Class B/2 (Secretin family receptors) ⁶⁵ G beta-gamma signalling through PLC beta ⁶⁵ Glucagon-type ligand receptors ⁶⁵ G-Protein Signaling through Tubby Protein ⁶³ Ionotropic activity of Kainate Receptors ⁶⁵	12.07	SCT GHRH GCG CALCA
4	cAMP signaling pathway ³⁶	11.94	VIP SST GCG
5	Salivary secretion ³⁶ Show member pathways Gastric acid secretion ³⁶	11.8	SST HRH2 GAST
6	G alpha (s) signalling events ⁶⁵	11.26	VIP SCT HRH2 GHRH GCG CALCA
7	Gastric acid production ¹	9.98	VIP SCT GAST
8	Secretion of Hydrochloric Acid in Parietal Cells ¹	9.96	HRH2 GAST

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GO Terms for Endocrine Pancreas Disease

Cellular components related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.56	SST SCT PPY GHRH GCG GAST
2	extracellular region	GO:0005576	9.32	VIP SST SPINK5 SCT PPY GHRH

Biological processes related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	feeding behavior	GO:0007631	9.33	PPY GCG CALCA
2	positive regulation of blood vessel diameter	GO:0097755	9.32	VIP CALCA
3	G protein-coupled receptor signaling pathway	GO:0007186	9.28	VIP SST SCT PPY HRH2 GHRH
4	response to food	GO:0032094	9.26	GHRH GAST
5	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.26	VIP GHRH GCG CALCA

Molecular functions related to Endocrine Pancreas Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	9.23	VIP SST SCT PPY GHRH GCG
2	peptide hormone receptor binding	GO:0051428	9.16	VIP GHRH
3	neuropeptide hormone activity	GO:0005184	9.13	VIP PPY GHRH

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Sources for Endocrine Pancreas Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia