MCID: END039
MIFTS: 48

Endodermal Sinus Tumor

Categories: Cancer diseases, Fetal diseases, Liver diseases

Aliases & Classifications for Endodermal Sinus Tumor

MalaCards integrated aliases for Endodermal Sinus Tumor:

Name: Endodermal Sinus Tumor 12 44 15
Yolk Sac Tumor 12 76 55 73
Infantile Embryonal Carcinoma 12
Hepatoid Yolk Sac Tumour 12
Yolk Sac Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1911
MeSH 44 D018240
NCIt 50 C3011
SNOMED-CT 68 74409009
UMLS 73 C0014145

Summaries for Endodermal Sinus Tumor

Disease Ontology : 12 A germ cell cancer that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Endodermal Sinus Tumor, also known as yolk sac tumor, is related to ovarian endodermal sinus tumor and testicular germ cell tumor. An important gene associated with Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and FOXA1 transcription factor network. The drugs Paclitaxel and Lenograstim have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and liver, and related phenotypes are Reduced mammosphere formation and reproductive system

Wikipedia : 76 Endodermal sinus tumor (EST), also known as yolk sac tumor (YST), is a member of the germ cell tumor... more...

Related Diseases for Endodermal Sinus Tumor

Diseases in the Endodermal Sinus Tumor family:

Adult Endodermal Sinus Tumor

Diseases related to Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 ovarian endodermal sinus tumor 33.5 SERPINA1 SALL4 GPC3 AFP
2 testicular germ cell tumor 32.3 GPC3 CGB3 AFP
3 testicular yolk sac tumor 31.4 SERPINA1 SALL4 GPC3 ALB AFP
4 mixed germ cell tumor 30.6 CGB3 AFP
5 mucinous cystadenofibroma 30.4 SERPINA1 AFP
6 cystadenofibroma 30.4 SERPINA1 AFP
7 testicular seminoma 30.4 CGB3 AFP
8 ovarian germ cell cancer 30.3 SALL4 AFP
9 ovarian embryonal carcinoma 30.3 GPC3 AFP
10 mucinous cystadenocarcinoma 30.2 VIM MUC16
11 malignant teratoma 30.1 SALL4 AFP
12 clear cell adenocarcinoma 30.0 KLK3 MUC16
13 seminal vesicle tumor 30.0 KLK3 GPC3 AFP
14 childhood endodermal sinus tumor 12.6
15 adult endodermal sinus tumor 12.5
16 childhood ovarian endodermal sinus tumor 12.5
17 mediastinal endodermal sinus tumors 12.4
18 macrocystic pattern testicular yolk sac tumor 12.4
19 solid pattern testicular yolk sac tumor 12.4
20 glandular-alveolar pattern testicular yolk sac tumor 12.4
21 myxomatous pattern testicular yolk sac tumor 12.4
22 papillary pattern testicular yolk sac tumor 12.4
23 enteric pattern testicular yolk sac tumor 12.4
24 reticular pattern testicular yolk sac tumor 12.4
25 central nervous system endodermal sinus tumor 12.4
26 endodermal sinus pattern testicular yolk sac tumor 12.3
27 polyvesicular vitelline pattern testicular yolk sac tumor 12.3
28 hepatoid pattern testicular yolk sac tumor 12.3
29 yolk sac tumor of central nervous system 11.9
30 vaginal yolk sac tumor 11.3
31 pineal region yolk sac tumor 11.3
32 glandular pattern ovarian yolk sac tumor 11.3
33 hepatoid pattern ovarian yolk sac tumor 11.3
34 polyvesicular vitelline pattern ovarian yolk sac tumor 11.3
35 teratoma 10.6
36 pineoblastoma 10.5
37 pineal gland cancer 10.5
38 pineocytoma 10.5
39 germ cells tumors 10.4
40 adenocarcinoma 10.3
41 embryonal carcinoma 10.3
42 polyembryoma 10.3 SERPINA1 AFP
43 hepatocellular carcinoma 10.2
44 down syndrome 10.2
45 gonadoblastoma 10.2
46 cardiac tamponade 10.2
47 mature teratoma 10.2
48 gastritis, familial giant hypertrophic 10.2 SERPINA1 ALB
49 hepatoid adenocarcinoma 10.2 ALB AFP
50 constrictive pericarditis 10.2 SERPINA1 ALB

Graphical network of the top 20 diseases related to Endodermal Sinus Tumor:



Diseases related to Endodermal Sinus Tumor

Symptoms & Phenotypes for Endodermal Sinus Tumor

GenomeRNAi Phenotypes related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 AFP ALB CHGA TIMP1 VIM

MGI Mouse Phenotypes related to Endodermal Sinus Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.1 AFP CHGA GPC3 SALL4 TIMP1 VIM

Drugs & Therapeutics for Endodermal Sinus Tumor

Drugs for Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 146)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2, Phase 3,Phase 3,Phase 1 33069-62-4 36314
2
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 135968-09-1
3
Bleomycin Approved, Investigational Phase 2, Phase 3,Phase 3 11056-06-7 5360373
4
Etoposide Approved Phase 2, Phase 3,Phase 3,Phase 1 33419-42-0 36462
5
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1 15663-27-1 2767 441203 84093
6
Oxaliplatin Approved, Investigational Phase 3,Phase 1 61825-94-3 43805 6857599 5310940 9887054
7
Mechlorethamine Approved, Investigational Phase 3,Phase 1,Phase 2 51-75-2 4033
8
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 1177-87-3
10
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 50-02-2 5743
11
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2 3375-50-6 598
12
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 6055-19-2, 50-18-0 2907
13
Captopril Approved Phase 3 62571-86-2 44093
14
Ribavirin Approved Phase 3 36791-04-5 37542
15
Palivizumab Approved, Investigational Phase 3 188039-54-5
16
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
17
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
18
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
19
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
20
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
21
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
22
Ondansetron Approved Phase 3 99614-02-5 4595
23
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
24
Promethazine Approved, Investigational Phase 3 60-87-7 4927
25
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
26
Vinblastine Approved Phase 3 865-21-4 241903 13342
27 Albumin-Bound Paclitaxel Phase 2, Phase 3,Phase 3,Phase 1
28 Etoposide phosphate Phase 2, Phase 3,Phase 3,Phase 1
29 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3,Phase 1
30 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 3
31 Topoisomerase Inhibitors Phase 2, Phase 3,Phase 3,Phase 1
32 Antimitotic Agents Phase 2, Phase 3,Phase 3,Phase 1
33 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3,Phase 1
34
Isophosphamide mustard Phase 3,Phase 1,Phase 2 0
35 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
36 Alkylating Agents Phase 3,Phase 1,Phase 2
37 Immunologic Factors Phase 3,Phase 1,Phase 2
38 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
39 Antimetabolites Phase 3,Phase 1,Phase 2
40 Anti-Infective Agents Phase 3,Phase 1,Phase 2
41 Antiviral Agents Phase 3,Phase 1,Phase 2
42 BB 1101 Phase 3,Phase 1,Phase 2
43 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2
44 Antihypertensive Agents Phase 3
45
protease inhibitors Phase 3,Phase 1
46 Antirheumatic Agents Phase 3,Phase 1
47 HIV Protease Inhibitors Phase 3,Phase 1
48 Angiotensin-Converting Enzyme Inhibitors Phase 3
49 Immunoglobulins Phase 3,Phase 1
50 Antibodies Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
4 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
6 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
9 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
12 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
13 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
14 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
15 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
16 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
17 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
18 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
19 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
20 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
21 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
22 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
23 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
24 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
25 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
26 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
27 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
28 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
29 Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Metastatic Testicular Cancer Completed NCT00004077 Phase 2 cisplatin;ifosfamide;paclitaxel
30 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
31 Temozolomide Followed by Radiation Therapy in Treating Children With Newly Diagnosed Malignant CNS Tumors Completed NCT00005955 Phase 2 temozolomide
32 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
33 Role of Axumin PET Scan in Germ Cell Tumor Recruiting NCT03426865 Phase 2 Axumin PET scan
34 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
35 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
36 MEN-10755 in Treating Patients With Solid Tumors Completed NCT00003982 Phase 1 sabarubicin
37 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
38 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
39 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
40 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
41 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
42 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
43 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
44 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
45 Biological Therapy in Treating Patients With Metastatic Cancer Completed NCT00004604 Phase 1
46 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
47 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
48 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
49 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
50 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate

Search NIH Clinical Center for Endodermal Sinus Tumor

Cochrane evidence based reviews: endodermal sinus tumor

Genetic Tests for Endodermal Sinus Tumor

Anatomical Context for Endodermal Sinus Tumor

MalaCards organs/tissues related to Endodermal Sinus Tumor:

41
Ovary, Testis, Liver, Bone, Pineal, Bone Marrow, Brain

Publications for Endodermal Sinus Tumor

Articles related to Endodermal Sinus Tumor:

(show top 50) (show all 718)
# Title Authors Year
1
Testicular Yolk Sac Tumor and Mature Teratoma: Synchronous Bilateral Occurrence in an Infant. ( 29608939 )
2018
2
A Rare Case of Pediatric Vaginal Yolk Sac Tumor. ( 29548872 )
2018
3
Malignant mixed ovarian germ cell tumor composed of immature teratoma, yolk sac tumor and embryonal carcinoma harboring an EGFR mutation: a case report. ( 30349318 )
2018
4
Peritoneal Carcinomatosis From Yolk Sac Tumor in a Postmenopausal Woman Following Chemotherapy for High-grade Ovarian Serous Carcinoma. ( 30383611 )
2018
5
Synchronous solitary calvarial yolk sac tumor metastasis as the initial presentation of mediastinal germ cell tumor. ( 29032518 )
2018
6
Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors. ( 29166820 )
2018
7
Primary mediastinal yolk sac tumor treated with platinum-based chemotherapy and extended resection: Report of seven cases. ( 29318787 )
2018
8
Abdominal Supernumerary Testis Complicated by Yolk Sac Tumor. ( 29482686 )
2018
9
Right Ventricular Heart Failure from a Cardiac Yolk Sac Tumor. ( 29497026 )
2018
10
Mediastinal yolk sac tumor infiltrating the heart. ( 29600980 )
2018
11
Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors. ( 29753846 )
2018
12
Ovarian yolk sac tumor in postmenopausal females: A case series and a literature review. ( 30113473 )
2018
13
Robot-assisted inguinal sentinel lymph node biopsy in primary yolk sac tumor of the vulva. ( 30217313 )
2018
14
Yolk Sac Tumor of Stomach: Case Report and Review of Literature. ( 30443123 )
2018
15
Is fertility sparing surgery a treatment option for young patients with yolk sac tumor? ( 30465413 )
2018
16
Vaginal Yolk Sac Tumor in an Infant. ( 28969744 )
2017
17
Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma. ( 28969004 )
2017
18
Yolk sac tumor of upper lip: A case report. ( 29113273 )
2017
19
A Case of Urachal Yolk Sac Tumor With Spontaneous Rupture in a Child. ( 27322711 )
2017
20
Yolk Sac Tumor in Extragonadal Pelvic Sites: Still a Diagnostic Challenge. ( 27631522 )
2017
21
Cushing syndrome in a child due to pro-opiomelanocortin (POMC) secretion from a yolk sac tumor. ( 27879325 )
2017
22
Unusual Presentations of Gynecologic Tumors: Extragonadal Yolk Sac Tumor of the Vulva. ( 27959583 )
2017
23
Living donor liver transplantation in a pediatric patient with preexisting yolk sac tumor. ( 28039901 )
2017
24
Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report. ( 28123734 )
2017
25
Chemotherapy for primary mediastinal yolk sac tumor in a patient undergoing chronic hemodialysis: a case report. ( 28202048 )
2017
26
Yolk sac tumor in the abdominal wall of an 18-month-old girl: a case report. ( 28215183 )
2017
27
Morphoproteomics Identifies the EZH2 and SIRT1 Pathways as Potential Blocks to Differentiation in Yolk Sac Tumor of the Ovary and Provides Therapeutic Options: a Case Study. ( 28249923 )
2017
28
Primary intrarenal yolk sac tumor. ( 28469308 )
2017
29
Endometrial Yolk Sac Tumor with Omental Metastasis. ( 28776560 )
2017
30
Tumor lysis syndrome in a patient with ovarian yolk sac tumor. ( 29159262 )
2017
31
Ovarian yolk sac tumor coexisting with epithelial ovarian cancer: An aggressive rare entity. ( 29204510 )
2017
32
Gastric cancer with adenocarcinoma and yolk sac tumor components: A rare entity. ( 29270580 )
2017
33
Bilateral lung metastases unveils an asymptomatic sacrococcygeal yolk sac tumor. ( 29323075 )
2017
34
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor. ( 26916077 )
2016
35
Successful treatment of mixed yolk sac tumor and mature teratoma in the spinal cord: case report. ( 27911225 )
2016
36
Germ Cell Tumor Targeting Chemotherapy in Gastric Adenocarcinoma with an Endodermal Sinus Tumor Component: A Case Report. ( 27351795 )
2016
37
Brief Report: A Second Primary Endodermal Sinus Tumor 9A Years after Initial Diagnosis. ( 27818263 )
2016
38
Retroperitoneal Endodermal Sinus Tumor Patient with Palliative Care Needs. ( 26962288 )
2016
39
Primary Endometrial Yolk Sac Tumor With Endodermal-Intestinal Differentiation Masquerading as Metastatic Colorectal Adenocarcinoma. ( 26598980 )
2016
40
Ovarian Yolk Sac Tumor with Granulomatous Reaction Resembling Tuberculosis - A Unique Presentation. ( 24585354 )
2016
41
Radiological-pathological correlation of yolk sac tumor in 20 patients. ( 25492969 )
2016
42
Primary orbital yolk sac tumor: report of a case and review of literature. ( 26481249 )
2016
43
Pelvic yolk sac tumor. ( 26776239 )
2016
44
Ovarian Yolk Sac Tumor With High-Grade Serous Carcinoma in a 62-Year-Old Woman. ( 26782153 )
2016
45
Is yolk sac tumor related to the pathophysiology of low birthweight? ( 26879004 )
2016
46
Giant Primary Yolk Sac Tumor of the Liver. ( 26956003 )
2016
47
Occult Mediastinal Yolk Sac Tumor Producing α-Fetoprotein Detected by 18F-FDG PET/CT. ( 27088388 )
2016
48
Ovarian Yolk Sac Tumor: The Experience of a Regional Cancer Center. ( 27104939 )
2016
49
A Rare Case of Primary Anterior Mediastinal Yolk Sac Tumor in an Elderly Adult Male. ( 27144043 )
2016
50
Successful radiotherapy in postoperative recurrence of a primary mediastinal yolk sac tumor: A case report. ( 27148423 )
2016

Variations for Endodermal Sinus Tumor

Expression for Endodermal Sinus Tumor

Search GEO for disease gene expression data for Endodermal Sinus Tumor.

Pathways for Endodermal Sinus Tumor

Pathways related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 AFP ALB SERPINA1 VIM
2
Show member pathways
10.82 KLK3 SERPINA1
3 10.6 AFP ALB

GO Terms for Endodermal Sinus Tumor

Cellular components related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 ALB KLK3 MUC16 SERPINA1 TIMP1 VIM
2 extracellular region GO:0005576 9.61 AFP ALB CGB3 CHGA GPC3 KLK3
3 endoplasmic reticulum lumen GO:0005788 9.55 AFP ALB GPC3 SERPINA1 TIMP1
4 platelet alpha granule lumen GO:0031093 9.43 ALB SERPINA1 TIMP1
5 extracellular space GO:0005615 9.28 AFP ALB CGB3 CHGA GPC3 KLK3

Biological processes related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.43 ALB SERPINA1 TIMP1
2 post-translational protein modification GO:0043687 9.35 AFP ALB GPC3 SERPINA1 TIMP1
3 negative regulation of peptidase activity GO:0010466 9.33 GPC3 SERPINA1 TIMP1
4 cellular protein metabolic process GO:0044267 9.1 AFP ALB GPC3 KLK3 SERPINA1 TIMP1

Molecular functions related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase inhibitor activity GO:0030414 8.8 GPC3 SERPINA1 TIMP1

Sources for Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
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51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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