MCID: END039
MIFTS: 42

Endodermal Sinus Tumor

Categories: Cancer diseases, Fetal diseases, Liver diseases

Aliases & Classifications for Endodermal Sinus Tumor

MalaCards integrated aliases for Endodermal Sinus Tumor:

Name: Endodermal Sinus Tumor 12 44 15 17
Yolk Sac Tumor 12 73 54 70
Infantile Embryonal Carcinoma 12
Hepatoid Yolk Sac Tumour 12
Endodermal Sinus Tumour 12
Yolk Sac Neoplasm 12
Yolk Sac Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1911
MeSH 44 D018240
NCIt 50 C3011
SNOMED-CT 67 74409009
UMLS 70 C0014145

Summaries for Endodermal Sinus Tumor

Disease Ontology : 12 A germ cell cancer that has material basis in cells that line the yolk sac of the embryo.

MalaCards based summary : Endodermal Sinus Tumor, also known as yolk sac tumor, is related to ovarian endodermal sinus tumor and childhood endodermal sinus tumor. An important gene associated with Endodermal Sinus Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Metabolism of proteins and Peptide hormone metabolism. The drugs Paclitaxel and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and pineal.

Wikipedia : 73 Endodermal sinus tumor (EST) is a member of the germ cell tumor group of cancers. It is the most common... more...

Related Diseases for Endodermal Sinus Tumor

Diseases in the Endodermal Sinus Tumor family:

Adult Endodermal Sinus Tumor

Diseases related to Endodermal Sinus Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 486)
# Related Disease Score Top Affiliating Genes
1 ovarian endodermal sinus tumor 33.0 KRT7 AFP
2 childhood endodermal sinus tumor 32.5 MIR371A MIR302A GATA6 AFP
3 ovarian embryonal carcinoma 31.1 TNFRSF8 AFP
4 mixed germ cell tumor 31.1 CGB3 AFP
5 clear cell adenocarcinoma 31.0 MUC16 KRT7 KLK3
6 appendix adenocarcinoma 30.8 KRT7 CHGA
7 testicular seminoma 30.8 CGB3 AFP
8 ovarian mixed germ cell neoplasm 30.8 SERPINA1 CEACAM5 AFP
9 chromosomal triplication 30.8 CGB3 AFP
10 polyembryoma 30.7 SERPINA1 AFP
11 urachal adenocarcinoma 30.7 CEACAM5 AFP
12 epididymo-orchitis 30.6 KLK3 AFP
13 teratoma 30.6 KRT7 GATA4 CHGA CGB5 CGB3 CEACAM5
14 gonadal germ cell tumor 30.6 CGB5 AFP
15 nonseminomatous germ cell tumor 30.6 CGB5 AFP
16 pericardial effusion 30.6 TNFRSF8 MUC16 ALB
17 benign teratoma 30.6 KRT7 CHGA CEACAM5 AFP
18 extragonadal germ cell cancer 30.6 CGB5 AFP
19 ovarian gonadoblastoma 30.5 TNFRSF8 AFP
20 ovarian mucinous cystadenocarcinoma 30.5 VIM CEACAM5
21 krukenberg carcinoma 30.5 KRT7 CEACAM5
22 mucinous adenocarcinoma 30.5 VIM MUC16 KRT7 CEACAM5
23 dysgerminoma of ovary 30.5 MIR371A ALPP AFP
24 neuroendocrine carcinoma 30.4 KRT7 CHGA CEACAM5
25 testicular germ cell cancer 30.4 MIR371A ALPP AFP
26 hydrocele 30.4 MIR371A KRT7 AFP
27 juvenile type testicular granulosa cell tumor 30.4 MIR302C AFP
28 mucoepidermoid carcinoma 30.4 KRT7 CHGA CEACAM5
29 benign mesothelioma 30.4 VIM KRT7 CEACAM5
30 hydronephrosis 30.4 KRT7 GATA4 ALB
31 cystadenofibroma 30.4 MUC16 KRT7 INHA
32 acinar cell carcinoma 30.4 SERPINA1 KRT7 CHGA AFP
33 central nervous system germinoma 30.4 MIR302C MIR302A ALPP
34 ovarian germ cell teratoma 30.4 MIR302C KRT7 AFP
35 cryptorchidism, unilateral or bilateral 30.3 GATA4 CGB5 ALPP ALPG AFP
36 tubular adenocarcinoma 30.3 KRT7 CHGA CEACAM5 AFP
37 mucinous cystadenocarcinoma 30.3 VIM MUC16 KRT7 CEACAM5
38 cystadenocarcinoma 30.3 VIM MUC16 KRT7 CEACAM5
39 testicular cancer 30.3 CGB5 CGB3 ALPP AFP
40 gonadoblastoma 30.2 CGB5 CGB3 ALPP ALPG
41 choriocarcinoma 30.2 CGB5 CGB3 ALPP ALPG
42 intestinal obstruction 30.2 KRT7 GATA4 CEACAM5 ALB
43 embryonal carcinoma 30.2 TNFRSF8 MIR302A GATA4 CGB5 CGB3 ALPG
44 ovarian germ cell cancer 30.1 MIR302C KRT7 CEACAM5 AFP
45 germ cell cancer 30.1 MIR371A MIR302C MIR302A GATA4 ALPP ALPG
46 seminoma 30.0 TNFRSF8 INHA CGB5 CGB3 ALPP ALPG
47 germinoma 29.9 MIR371A MIR302A INHA CGB5 CGB3 ALPP
48 dysgerminoma 29.9 MIR371A MIR302C KRT7 INHA ALPP ALPG
49 sertoli-leydig cell tumor 29.9 MIR302C KRT7 INHA ALPP AFP
50 mature teratoma 29.8 TNFRSF8 MIR371A MIR302C MIR302A KRT7 CEACAM5

Graphical network of the top 20 diseases related to Endodermal Sinus Tumor:



Diseases related to Endodermal Sinus Tumor

Symptoms & Phenotypes for Endodermal Sinus Tumor

Drugs & Therapeutics for Endodermal Sinus Tumor

Drugs for Endodermal Sinus Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
2
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
3
Promethazine Approved, Investigational Phase 3 60-87-7 4927
4
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
5
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
6 Albumin-Bound Paclitaxel Phase 3
7 Histamine H2 Antagonists Phase 3
8 Antibiotics, Antitubercular Phase 3
9 Anti-Bacterial Agents Phase 3
10
Mesna Approved, Investigational Phase 2 3375-50-6 598
11
Etoposide Approved Phase 2 33419-42-0 36462
12
Ifosfamide Approved Phase 2 3778-73-2 3690
13
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
14
Lenograstim Approved, Investigational Phase 2 135968-09-1
15
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
16
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
17
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
18
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
19
Levonorgestrel Approved, Investigational Phase 2 797-63-7, 17489-40-6 13109
20
Molgramostim Investigational Phase 2 99283-10-0
21 Immunologic Factors Phase 2
22 Tubulin Modulators Phase 2
23 Etoposide phosphate Phase 2
24 Antimitotic Agents Phase 2
25 Adjuvants, Immunologic Phase 2
26 Alkylating Agents Phase 2
27
Isophosphamide mustard Phase 2 100427
28 Keratolytic Agents Phase 2
29 Dermatologic Agents Phase 2
30 Podophyllotoxin Phase 2 518-28-5
31 Immunosuppressive Agents Phase 2
32 Protective Agents Phase 2
33
Ipilimumab Approved Phase 1 477202-00-9
34
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
35
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
36
Sunitinib Approved, Investigational Phase 1 557795-19-4, 341031-54-7 5329102
37
Fluorouracil Approved Phase 1 51-21-8 3385
38
Levoleucovorin Approved, Investigational Phase 1 68538-85-2 149436
39
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 43805 6857599
40
leucovorin Approved Phase 1 58-05-9 6006
41
Bortezomib Approved, Investigational Phase 1 179324-69-7 93860 387447
42
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
43
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
44
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
45
Tyrosine Approved, Investigational, Nutraceutical Phase 1 60-18-4 6057
46
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
47 Immunoglobulins, Intravenous Phase 1
48 Antineoplastic Agents, Immunological Phase 1
49 Antibodies Phase 1
50 Immunoglobulins Phase 1

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Phase III Study Of Reduced Therapy In The Treatment Of Children With Low And Intermediate Risk Extracranial Germ Cell Tumors Unknown status NCT00053352 Phase 3 cisplatin;etoposide
2 A Randomized Phase III Trial Comparing Conventional-Dose Chemotherapy Using Paclitaxel, Ifosfamide, and Cisplatin (TIP) With High-Dose Chemotherapy Using Mobilizing Paclitaxel Plus Ifosfamide Followed by High-Dose Carboplatin and Etoposide (TI-CE) as First Salvage Treatment in Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
3 A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide;Etoposide Phosphate
4 Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors With Paclitaxel, Ifosfamide and Carboplatin Completed NCT00467051 Phase 2 Carboplatin;Ifosfamide;Paclitaxel
5 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Not yet recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
6 CTLA-4 Blockade With MDX-010 to Induce Graft-Versus-Malignancy Effects Following Allogeneic Hematopoietic Stem Cell Transplantation Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
7 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
8 A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
9 A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
10 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
11 A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors Completed NCT00929903 Phase 1 pazopanib hydrochloride
12 Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressing Autologous T Cells as an Immunotherapy for Children With Solid Tumors (CARE) Not yet recruiting NCT04715191 Phase 1 Cytoxan;Fludara
13 Interleukin-15 Armored Glypican-3-specific Chimeric Antigen Receptor Expressing Autologous T Cells as Immunotherapy for Children With Solid Tumors Not yet recruiting NCT04377932 Phase 1 Cytoxan;Fludara
14 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
15 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355
16 A Prospective Study of Cognitive Function During Chemotherapy for Front-Line Treatment of Ovarian, Primary Peritoneal or Fallopian Tube Cancer Completed NCT01080521
17 Anti-1-amino-3-18F-flurocyclobutane-1-carboxylic Acid (Axumin) Positron Emission Tomography/Computed Tomography Prior to Retroperitoneal Lymph Node Dissection for Testicular Cancer Completed NCT03426865 Axumin PET scan
18 Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. Recruiting NCT04283773

Search NIH Clinical Center for Endodermal Sinus Tumor

Cochrane evidence based reviews: endodermal sinus tumor

Genetic Tests for Endodermal Sinus Tumor

Anatomical Context for Endodermal Sinus Tumor

MalaCards organs/tissues related to Endodermal Sinus Tumor:

40
Ovary, Testis, Pineal, Liver, Lymph Node, Spinal Cord, Brain

Publications for Endodermal Sinus Tumor

Articles related to Endodermal Sinus Tumor:

(show top 50) (show all 1871)
# Title Authors PMID Year
1
Two cases of primary yolk sac tumor of the liver in childhood: case reports and literature review. 61 54
19284801 2009
2
The utility of microscopic findings and immunohistochemistry in the classification of necrotic testicular tumors: a study of 11 cases. 54 61
19461507 2009
3
Alpha-fetoprotein (AFP)-producing ovarian tumor in an elderly woman. 61 54
19225928 2009
4
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. 54 61
18525461 2008
5
Gastric yolk sac tumor complicated with beta-human chorionic gonadotropin-producing metastases. 61 54
19075540 2008
6
Alpha-fetoprotein-producing serous carcinoma of the uterus metastasizing to the ovaries, mimicking primary ovarian yolk sac tumor: a case report and review of the literature. 61 54
17197899 2007
7
Yolk sac tumor of the ovary during pregnancy: a case report. 61 54
16051324 2005
8
Novel human alpha-fetoprotein mRNA isoform lacking exon 1 identified in ovarian yolk sac tumor. 54 61
15914041 2005
9
Regulatory role of CCAAT/enhancer binding protein-beta in the production of plasma proteins in yolk sac tumor. 61 54
15924879 2005
10
Epidemiological and clinical behavior of prepubertal testicular tumors in Korea. 54 61
15247758 2004
11
Juvenile granulosa cell tumor of the testis:: contemporary clinical management and pathological diagnosis. 54 61
15076304 2004
12
Gastric adenocarcinoma with a yolk sac component: a case report and review of the literature. 54 61
10914786 2000
13
Ovarian mucinous cystadenocarcinoma with yolk sac tumor in a 71-year-old woman. 61 54
12090598 1999
14
Yolk sac tumor of the stomach with an adenocarcinomatous component: a case report with immunohistochemical analysis. 61 54
10469400 1999
15
Hepatocytic differentiation in retiform Sertoli-Leydig cell tumors: distinguishing a heterologous element from Leydig cells. 61 54
10374766 1999
16
Detection of alpha-fetoprotein mRNA in seminoma. 54 61
10386812 1999
17
Postchemotherapy retroperitoneal residual mass in infantile yolk sac tumor. 54 61
10226820 1999
18
Histologically pure seminoma with elevated alpha-fetoprotein: a clinicopathologic study of ten cases. 54 61
9769381 1998
19
Ovarian endometrioid adenocarcinoma with ectopic production of alpha-fetoprotein. 54 61
9784334 1998
20
Germ cell tumors of the mediastinum and testis: a comparative immunohistochemical study of 120 cases. 61 54
9670832 1998
21
Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review. 54 61
9702861 1998
22
Developmental alterations of alpha-fetoprotein sugar chain in amniotic fluids analyzed by lectin affinity electrophoresis. 61 54
9548991 1998
23
Alpha-fetoprotein (AFP) levels in normal children. 54 61
9402482 1997
24
The role of subfractionation of alpha-fetoprotein in the treatment of pediatric surgical patients. 61 54
9094031 1997
25
Actual half-life of alpha-fetoprotein as a prognostic tool in pediatric malignant tumors. 61 54
9354734 1997
26
[Combined treatment with resection, intraoperative hypotonic and post-operative systemic chemotherapy using cis-platinum for a mediastinal yolk sac tumor: a case report]. 61 54
8958689 1996
27
Yolk sac tumor of the liver combined with hepatocellular carcinoma. 54 61
8757478 1996
28
Biochemical characterization of alpha-fetoprotein and other serum proteins produced by a uterine endometrial adenocarcinoma. 54 61
8766525 1996
29
Intracranial immature teratoma with syncytiotrophoblasts and tumor marker positive intestinal lining cells. 54 61
8599256 1995
30
Fine needle aspiration cytology of primary mediastinal germ cell tumors. 61 54
7543237 1995
31
[The phenotypic expressions of AFP producing gastric carcinoma]. 61 54
7537833 1995
32
Immunoelectrophoretic differentiation of alpha-fetoprotein in disorders with elevated serum alpha-fetoprotein levels or during pregnancy. 61 54
7492383 1995
33
Clinical significance of serum alpha-fetoprotein subfractionation in pediatric diseases. 54 61
7524830 1994
34
Treatment of nongerminomatous germ-cell tumors of the pineal region. 54 61
7514765 1994
35
Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. 54 61
7507794 1994
36
Production of alpha-fetoprotein by human submandibular gland. 54 61
7507351 1993
37
Increased serum levels of monosialo-alpha-fetoprotein in hepatocellular carcinoma and other malignancies. 54 61
7694351 1993
38
[Intracranial germ cell tumors]. 54 61
1320996 1992
39
[Alpha-fetoprotein in non-hepatocellular malignant tumors]. 54 61
1716196 1991
40
MR imaging of pineal tumors. 54 61
2162137 1990
41
Alpha-fetoprotein (AFP)-producing gastric carcinoma. Is it hepatoid differentiation? 61 54
1690592 1990
42
[A case of mediastinal yolk sac tumor successfully treated with chemotherapy and surgery]. 61 54
2348134 1990
43
Germ cell neoplasms of head and neck soft tissues: a pathologic spectrum of teratomatous and endodermal sinus tumors. 54 61
1690172 1990
44
Management of advanced endodermal sinus tumor of the ovary with preservation of reproductive function. 54 61
2228718 1990
45
Vasculogenic Mesenchymal Tumor: A Clinicopathologic and Molecular Study of 55 Cases of a Distinctive Neoplasm Originating From Mediastinal Yolk Sac Tumor and an Occasional Precursor to Angiosarcoma. 61
33136584 2021
46
Primary intracranial pure endodermal sinus tumor: a retrospective series of 6 cases in a single center and a systematic review of overall survival. 61
33753128 2021
47
Yolk Sac Tumor Arising in Uterine Carcinosarcoma With Endometrioid and Serous Components: A Case Report With Immunohistochemical Analysis. 61
33770060 2021
48
Unusual Presentation, Relapse, and Metastasis of a Pediatric Testicular Yolk Sac Tumor: Case Report. 61
33141029 2021
49
Surveillance Only for High-risk FIGO Stage IA/IB Malignant Ovarian Germ Cell Tumors: Results From a National Cancer Database. 61
33710136 2021
50
Malignant sacrococcygeal germ cell tumors in childhood: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience. 61
33219741 2021

Variations for Endodermal Sinus Tumor

Expression for Endodermal Sinus Tumor

Search GEO for disease gene expression data for Endodermal Sinus Tumor.

Pathways for Endodermal Sinus Tumor

GO Terms for Endodermal Sinus Tumor

Cellular components related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SERPINA1 MUC16 KLK3 INHA CHGA CGB5
2 extracellular region GO:0005576 9.36 SERPINA1 MUC16 KLK3 INHA CHGA CGB5

Biological processes related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.62 INHA GATA4 CGB5 CGB3
2 SMAD protein signal transduction GO:0060395 9.33 VIM INHA AFP
3 intestinal epithelial cell differentiation GO:0060575 9.26 GATA6 GATA4
4 cellular protein metabolic process GO:0044267 9.02 SERPINA1 KLK3 GATA6 ALB AFP
5 positive regulation of cardioblast differentiation GO:0051891 8.96 GATA6 GATA4

Molecular functions related to Endodermal Sinus Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alkaline phosphatase activity GO:0004035 8.62 ALPP ALPG

Sources for Endodermal Sinus Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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