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MCID: END040
MIFTS: 50

Endogenous Depression

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Endogenous Depression

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MalaCards integrated aliases for Endogenous Depression:

Name: Endogenous Depression 12 15 73
Clinical Depression 12 55 73
Unipolar Depression 12 73
Depressive Disorder 44 73

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1595
MeSH 44 D003866
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Summaries for Endogenous Depression

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Disease Ontology : 12 A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.

MalaCards based summary : Endogenous Depression, also known as clinical depression, is related to depression and postpartum depression, and has symptoms including depressed - symptom An important gene associated with Endogenous Depression is TRH (Thyrotropin Releasing Hormone), and among its related pathways/superpathways are NF-KappaB Family Pathway and Spinal Cord Injury. The drugs Adenosine and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and thyroid, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Endogenous depression (melancholia) is an atypical sub-class of the mood disorder, major depressive... more...

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Related Diseases for Endogenous Depression

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Diseases related to Endogenous Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 depression 31.4 BDNF CRH MAOA SLC6A4
2 postpartum depression 31.1 BDNF CRH IER3IP1 MAOA SLC6A4
3 melancholia 30.8 CRH IER3IP1
4 amenorrhea 29.7 CRH GNRH1 POMC TRH
5 major depressive disorder 28.8 BDNF CRH GATA3 IL1B MAOA OXT
6 premenstrual tension 28.4 CRH GNRH1 OXT POMC
7 anxiety 28.3 BDNF CRH MAOA OXT SLC6A4
8 anorexia nervosa 27.7 BDNF CRH OXT POMC SLC6A4
9 autoimmune myocarditis 10.8 IL1B IL2
10 uremic pruritus 10.7 IL1B IL2
11 craniopharyngioma 10.7 GNRH1 INS TRH
12 burns 10.6 CRH IL1B INS
13 scleredema adultorum 10.6 INS POMC
14 adenohypophysitis 10.6 POMC TRH
15 pituitary infarct 10.6 GNRH1 POMC
16 chiasmal syndrome 10.5 GNRH1 POMC
17 suprasellar meningioma 10.5 POMC TRH
18 tuberculous empyema 10.5 IL2 POMC
19 hyperpituitarism 10.4 INS POMC TRH
20 psychosexual disorder 10.4 HTR7 SLC6A4
21 cerebral artery occlusion 10.4 BDNF IL1B
22 empty sella syndrome 10.4 GNRH1 POMC TRH
23 pituitary carcinoma 10.4 CRH POMC
24 pituitary apoplexy 10.4 GNRH1 INS POMC
25 thyroid gland disease 10.4 INS POMC TRH
26 retrograde amnesia 10.4 POMC SLC6A4
27 cell type benign neoplasm 10.4 INS POMC TRH
28 sex differentiation disease 10.4 GNRH1 INS POMC
29 paranoid schizophrenia 10.4 BDNF MAOA SLC6A4
30 borderline personality disorder 10.4 BDNF MAOA SLC6A4
31 generalized anxiety disorder 10.4 BDNF MAOA SLC6A4
32 hyperprolactinemia 10.4 GNRH1 POMC TRH
33 sheehan syndrome 10.4 CRH INS POMC
34 splenic abscess 10.4 IER3IP1 LIPA
35 hypothalamic disease 10.3 CRH GNRH1 POMC
36 personality disorder 10.3 BDNF MAOA SLC6A4
37 hyperandrogenism 10.3 GNRH1 INS POMC
38 bulimia nervosa 10.3 BDNF MAOA SLC6A4
39 acth deficiency, isolated 10.3 CRH POMC
40 endocrine organ benign neoplasm 10.3 CRH POMC TRH
41 euthyroid sick syndrome 10.3 IL1B POMC
42 acromegaly 10.3 INS POMC TRH
43 substance abuse 10.3 BDNF MAOA SLC6A4
44 brunner syndrome 10.3 HTR7 MAOA SLC6A4
45 bronchial disease 10.3 GATA3 IER3IP1 IL1B
46 diabetes insipidus 10.3 CRH INS POMC
47 central nervous system disease 10.3 BDNF IER3IP1 IL1B
48 urinary system disease 10.3 CRH INS POMC
49 childhood disintegrative disease 10.3 BDNF POMC
50 irritable bowel syndrome 10.2 CRH HTR7 SLC6A4

Graphical network of the top 20 diseases related to Endogenous Depression:



Diseases related to Endogenous Depression
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Symptoms & Phenotypes for Endogenous Depression

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UMLS symptoms related to Endogenous Depression:


depressed - symptom

MGI Mouse Phenotypes related to Endogenous Depression:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 BDNF HTR7 CRH IL2 OXT LIPA
2 growth/size/body region MP:0005378 10.22 GNRH1 CRH IL1B IL2 GATA3 BDNF
3 homeostasis/metabolism MP:0005376 10.21 HTR7 CRH IL1B IL2 GATA3 BDNF
4 endocrine/exocrine gland MP:0005379 10.17 CRH IL2 GATA3 BDNF GNRH1 LIPA
5 cardiovascular system MP:0005385 10.13 IL1B IL2 GATA3 INS OXT LIPA
6 integument MP:0010771 10.06 HTR7 CRH IL1B GATA3 INS BDNF
7 digestive/alimentary MP:0005381 10 GNRH1 BDNF IL2 GATA3 INS OXT
8 mortality/aging MP:0010768 10 BDNF HTR7 IL1B IL2 GATA3 INS
9 adipose tissue MP:0005375 9.99 CRH GATA3 INS OXT LIPA POMC
10 nervous system MP:0003631 9.97 HTR7 CRH IL1B GATA3 BDNF GNRH1
11 no phenotypic analysis MP:0003012 9.5 BDNF CRH IL2 GATA3 INS POMC
12 renal/urinary system MP:0005367 9.17 GNRH1 CRH GATA3 INS OXT LIPA
Sources

Drugs & Therapeutics for Endogenous Depression

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Drugs for Endogenous Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational 58-61-7 60961
2 Analgesics
3 Anti-Arrhythmia Agents
4 Neurotransmitter Agents
5 Peripheral Nervous System Agents
6 Vasodilator Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Endogenous Depression

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: depressive disorder

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Genetic Tests for Endogenous Depression

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Anatomical Context for Endogenous Depression

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MalaCards organs/tissues related to Endogenous Depression:

41
Testes, Pituitary, Thyroid, Brain, Liver, Amygdala
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Publications for Endogenous Depression

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Articles related to Endogenous Depression:

(show top 50) (show all 402)
# Title Authors Year
1
Brief Social Isolation in the Adolescent Wistar-Kyoto Rat Model of Endogenous Depression Alters Corticosterone and Regional Monoamine Concentrations. ( 28233145 )
2017
2
Immediate and delayed anxiety- and depression-like profiles in the adolescent Wistar-Kyoto rat model of endogenous depression following postweaning social isolation. ( 28017851 )
2017
3
Lipid parameters - significance in patients with endogenous depression. ( 24596713 )
2014
4
Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. ( 21079605 )
2012
5
Early syphilitic meningoencephalitis masquerading as postclimacteric endogenous depression--a unique dermatologic presentation. ( 21913574 )
2011
6
Hormonal responses to the 5-HT1A agonist buspirone in remitted endogenous depressive patients after long-term imipramine treatment. ( 19762159 )
2010
7
Neonatal clomipramine induced endogenous depression in rats is associated with learning impairment in adulthood. ( 17889946 )
2008
8
Gender based response to fluoxetine hydrochloride medication in endogenous depression. ( 15228850 )
2004
9
Decrease of the platelet 5-HT2A receptor function by long-term imipramine treatment in endogenous depression. ( 15181653 )
2004
10
Alterations in voiding frequency and cystometry in the clomipramine induced model of endogenous depression and reversal with fluoxetine. ( 14532855 )
2003
11
The effect of antidepressants on serum melatonin levels in endogenous depression. ( 12568211 )
2002
12
Endogenous depression, thyroid function and acupuncture. ( 11211567 )
2001
13
Negative attributional style, hopelessness depression and endogenous depression. ( 11153969 )
2001
14
[Interleukin level in endogenous depression]. ( 11586704 )
2001
15
Ontogeny of REM sleep in rats: possible implications for endogenous depression. ( 10713284 )
2000
16
Clinical variables as predictors of response to electroconvulsive therapy in endogenous depression. ( 21407910 )
2000
17
Alterations in the levels of monoamines in discrete brain regions of clomipramine-induced animal model of endogenous depression. ( 10215507 )
1999
18
Effects of electroconvulsive therapy in adolescents with severe endogenous depression resistant to pharmacotherapy. ( 9513748 )
1998
19
Different effects of pyridostigmine on the thyrotropin response to thyrotropin-releasing hormone in endogenous depression and subclinical thyrotoxicosis. ( 9440477 )
1998
20
On the problems of switching from intravenous to oral administration in drug treatment of endogenous depression--a placebo-controlled double-blind trial with doxepin. ( 9131726 )
1997
21
Typus melancholicus is not the premorbid personality trait of unipolar (endogenous) depression. ( 9316163 )
1997
22
Decreased dorsal raphe nucleus neuronal activity in adult chloral hydrate anesthetized rats following neonatal clomipramine treatment: implications for endogenous depression. ( 9187315 )
1997
23
Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission. ( 9335199 )
1997
24
Neuroendocrine aspects of primary endogenous depression. XV: Mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls. ( 9109182 )
1997
25
Problems in validating endogenous depression in the Arab culture by contemporary diagnostic criteria. ( 9241573 )
1997
26
No early effects of electroconvulsive therapy on tryptophan metabolism and disposition in endogenous depression. ( 9232212 )
1997
27
Experimental studies of the therapeutic action of electroconvulsive therapy in endogenous depression. The role of the electrical stimulation and of the seizure studied by variation of stimulus intensity and modification by lidocaine of seizure discharge. ( 8872406 )
1996
28
Neuroendocrine aspects of primary endogenous depression--XIV. Gonadotropin secretion in female patients and their matched controls. ( 8584601 )
1995
29
Electrophysiological activity of raphe dorsalis serotoninergic neurones in a possible model of endogenous depression. ( 7605927 )
1995
30
Brofaromine in endogenous depression. ( 8208975 )
1994
31
Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate? ( 7838010 )
1994
32
Kynurenine in blood plasma and DST in patients with endogenous anxiety and endogenous depression. ( 7948450 )
1994
33
Psychophysiological characteristics and metabolic indices of neurotransmitter metabolism in patients ill with endogenous depression. ( 7916466 )
1994
34
Life events and endogenous depression. A puzzle reexamined. ( 8031225 )
1994
35
Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. II. The central noradrenergic and neuropeptide Y pathways cause immediate and prolonged hypothalamic-pituitary-adrenal activation. Potential involvement in the pseudo-Cushing's syndrome of endogenous depression and anorexia nervosa. ( 8163648 )
1994
36
Subclinical hypothyroidism resulting from autoimmune thyroiditis in female patients with endogenous depression. ( 7868803 )
1994
37
Neuroendocrine and sleep variables in endogenous depression: the role of severity. ( 7502650 )
1994
38
Neuroendocrine aspects of primary endogenous depression. XIII. Influence of race on differences in hypothalamo-pituitary-adrenal and pituitary-thyroid function between patients and matched controls. ( 8110917 )
1993
39
Response to somatic treatment and placebo in patients with melancholia/endogenous depression. ( 8280275 )
1993
40
Multiple HPA profiles in endogenous depression: effect of age and sex on cortisol and beta-endorphin. ( 8382535 )
1993
41
Seizure duration and related issues in ect for endogenous depression. ( 21776168 )
1993
42
Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls. ( 8364347 )
1993
43
Decreased raphe unit activity in a rat model of endogenous depression. ( 8390911 )
1993
44
Endogenous depression: current classifications and new treatments. ( 8444593 )
1993
45
Percutaneous endoscopic gastrostomy and severe endogenous depression. ( 8298856 )
1993
46
The role of moclobemide in endogenous depression: a survey of recent data. ( 8468434 )
1993
47
The disruption of intracortical interaction in endogenous depression. ( 8332243 )
1993
48
Profiles of spontaneous 24-hour and stimulated growth hormone secretion in male patients with endogenous depression. ( 8372160 )
1993
49
Endogenous depression in the elderly: prevalence and agreement among measures. ( 1592961 )
1992
50
Moclobemide versus clomipramine in endogenous depression. A double-blind randomised clinical trial. ( 1571752 )
1992
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Variations for Endogenous Depression

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Expression for Endogenous Depression

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Search GEO for disease gene expression data for Endogenous Depression.
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Pathways for Endogenous Depression

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Pathways related to Endogenous Depression according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
NF-KappaB Family Pathway 64
Show member pathways
 12.38 BDNF GNRH1 IL1B IL2 LTBP3
2
Spinal Cord Injury 1
11.77 BDNF IL1B IL2
3
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.73 BDNF GNRH1 IL1B IL2 LTBP3
4
Serotonergic synapse 37
11.72 HTR7 MAOA SLC6A4
5
Corticotropin-releasing hormone signaling pathway 1
11.62 CRH IL2 POMC
6
Glucocorticoid receptor regulatory network 1
11.55 GATA3 IL2 POMC
7
Innate Lymphoid Cell Differentiation Pathways 65
11.51 GATA3 IL1B IL2
8
Interleukin-4 and 13 signaling 66
11.51 GATA3 IL1B MAOA POMC
9
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.23 BDNF GATA3 IL1B MAOA SLC6A4
10
Monoamine Transport 1
Show member pathways
 11.07 IL1B MAOA SLC6A4
11
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.58 HTR7 MAOA SLC6A4
12
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
10.25 CRH POMC
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GO Terms for Endogenous Depression

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Cellular components related to Endogenous Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 BDNF CRH GNRH1 IL1B IL2 INS
2 extracellular region GO:0005576 9.65 BDNF CRH GNRH1 IL1B IL2 INS
3 secretory granule GO:0030141 8.92 IL1B OXT POMC TRH

Biological processes related to Endogenous Depression according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 9.86 CRH GNRH1 HTR7 IL2 INS OXT
2 positive regulation of gene expression GO:0010628 9.8 CRH GATA3 IL1B INS SLC6A4
3 response to organic cyclic compound GO:0014070 9.76 GNRH1 OXT TRH
4 cytokine-mediated signaling pathway GO:0019221 9.72 GATA3 IL1B IL2 MAOA POMC
5 female pregnancy GO:0007565 9.71 CRH GNRH1 OXT
6 memory GO:0007613 9.69 BDNF OXT SLC6A4
7 positive regulation of T cell differentiation GO:0045582 9.58 GATA3 IL2
8 vasoconstriction GO:0042310 9.57 HTR7 SLC6A4
9 negative regulation of lipid catabolic process GO:0050995 9.56 IL1B INS
10 response to corticosterone GO:0051412 9.55 CRH TRH
11 response to ethanol GO:0045471 9.55 CRH GATA3 GNRH1 IL2 TRH
12 cell-cell signaling GO:0007267 9.5 BDNF GNRH1 IL1B IL2 INS POMC
13 response to prostaglandin E GO:0034695 9.49 GNRH1 OXT
14 negative regulation of feeding behavior GO:2000252 9.48 INS TRH
15 positive regulation of prostaglandin secretion GO:0032308 9.46 IL1B OXT
16 sperm ejaculation GO:0042713 9.43 OXT SLC6A4
17 response to ether GO:0045472 9.37 CRH OXT
18 regulation of signaling receptor activity GO:0010469 9.23 BDNF GNRH1 IL1B IL2 INS OXT
19 signal transduction GO:0007165 10.13 CRH GATA3 GNRH1 HTR7 IL1B OXT

Molecular functions related to Endogenous Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-2 receptor binding GO:0005134 9.16 GATA3 IL2
2 neuropeptide hormone activity GO:0005184 9.13 CRH OXT POMC
3 hormone activity GO:0005179 9.1 CRH GNRH1 INS OXT POMC TRH
Sources

Sources for Endogenous Depression

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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