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MCID: END040
MIFTS: 56

Endogenous Depression

Categories: Mental diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Endogenous Depression

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MalaCards integrated aliases for Endogenous Depression:

Name: Endogenous Depression 12 15 73
Unipolar Depression 12 15 73
Clinical Depression 12 55 73
Depressive Disorder 44 73

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1595
MeSH 44 D003866
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Summaries for Endogenous Depression

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Disease Ontology : 12 A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.

MalaCards based summary : Endogenous Depression, also known as unipolar depression, is related to atypical depressive disorder and postpartum depression, and has symptoms including depressed - symptom An important gene associated with Endogenous Depression is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Adenosine and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and pituitary, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Endogenous depression (melancholia) is an atypical sub-class of the mood disorder, major depressive... more...

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Related Diseases for Endogenous Depression

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Diseases related to Endogenous Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 atypical depressive disorder 33.2 CRH HTR2A HTR7 MAOA SLC6A4
2 postpartum depression 31.6 BDNF CRH IER3IP1 MAOA SLC6A4
3 schizoaffective disorder 30.6 BDNF HTR2A SLC6A4
4 major depressive disorder 30.4 BDNF CRH CRHR1 HTR1A HTR2A IL1B
5 melancholia 30.4 CRH IER3IP1
6 bipolar disorder 30.3 BDNF CRH HTR1A HTR2A MAOA NR3C1
7 depression 30.3 BDNF CRH CRHR1 HTR1A HTR2A MAOA
8 dysthymic disorder 30.1 HTR2A HTR7 MAOA SLC6A4
9 alcohol abuse 30.0 BDNF HTR2A SLC6A4
10 bipolar i disorder 30.0 BDNF HTR1A HTR2A SLC6A4
11 social phobia 30.0 HTR1A MAOA SLC6A4
12 amenorrhea 30.0 CRH GNRH1 TRH
13 conduct disorder 29.9 MAOA SLC6A4 TPH1
14 tobacco addiction 29.9 HTR2A MAOA SLC6A4 TPH1
15 personality disorder 29.9 BDNF HTR1A HTR2A MAOA SLC6A4 TPH1
16 paranoid schizophrenia 29.8 BDNF HTR2A MAOA SLC6A4
17 obsessive-compulsive disorder 29.8 BDNF CRH HTR1A HTR2A MAOA SLC6A4
18 temporal lobe epilepsy 29.8 BDNF HTR1A NPY
19 hypothalamic disease 29.7 CRH GNRH1
20 post-traumatic stress disorder 29.6 BDNF CRH HTR2A IL1B MAOA NR3C1
21 psychotic disorder 29.6 BDNF HTR1A HTR2A SLC6A4 TPH1
22 panic disorder 29.6 BDNF CRH CRHR1 HTR1A HTR2A MAOA
23 eating disorder 29.5 BDNF CRH NPY SLC6A4
24 agoraphobia 29.5 HTR1A MAOA SLC6A4
25 sleep apnea 29.3 HTR2A IL1B INS
26 attention deficit-hyperactivity disorder 29.3 BDNF HTR1A HTR2A MAOA NPY SLC6A4
27 fibromyalgia 29.3 CRH HTR2A NPY SLC6A4
28 kleptomania 29.3 HTR1A HTR7 MAOA SLC6A4
29 autism 29.2 BDNF HTR1A HTR2A HTR7 MAOA SLC6A4
30 borderline personality disorder 29.1 BDNF HTR1A HTR2A MAOA NR3C1 SLC6A4
31 asthma 29.1 BDNF CRH IL1B INS NPY NR3C1
32 chronic fatigue syndrome 29.1 CRH HTR1A HTR2A IL1B IL2 MAOA
33 irritable bowel syndrome 29.1 CRH CRHR1 HTR7 SLC6A4 TPH1
34 substance abuse 29.1 BDNF MAOA NPY SLC6A4
35 generalized anxiety disorder 29.1 BDNF CRHR1 HTR1A HTR2A MAOA SLC6A4
36 bulimia nervosa 29.0 BDNF HTR2A NPY SLC6A4
37 anorexia nervosa 29.0 BDNF CRH HTR2A NPY SLC6A4
38 migraine with or without aura 1 29.0 HTR1A HTR2A HTR7 IER3IP1 MAOA SLC6A4
39 disease of mental health 28.9 BDNF CRH HTR1A HTR2A HTR7 IER3IP1
40 intermittent explosive disorder 28.9 HTR1A HTR7 NPY SLC6A4
41 alcohol dependence 28.9 BDNF CRHR1 HTR1A HTR2A MAOA NPY
42 parkinson disease, late-onset 28.9 BDNF HTR1A HTR2A IER3IP1 MAOA SLC6A4
43 mood disorder 28.5 BDNF CRH CRHR1 HTR1A HTR2A MAOA
44 schizophrenia 28.3 BDNF HTR1A HTR2A HTR7 MAOA NPY
45 mental depression 28.3 BDNF CRH CRHR1 HTR1A HTR2A HTR7
46 anxiety 28.1 BDNF CRH CRHR1 HTR1A HTR2A MAOA
47 neurotic disorder 11.4
48 major depressive disorder 1 11.3
49 major depressive disorder 2 11.3
50 major affective disorder 1 10.4

Graphical network of the top 20 diseases related to Endogenous Depression:



Diseases related to Endogenous Depression
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Symptoms & Phenotypes for Endogenous Depression

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UMLS symptoms related to Endogenous Depression:


depressed - symptom

MGI Mouse Phenotypes related to Endogenous Depression:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.31 BDNF CRH CRHR1 HTR1A HTR2A HTR7
2 homeostasis/metabolism MP:0005376 10.24 BDNF CRH CRHR1 GNRH1 HTR1A HTR7
3 growth/size/body region MP:0005378 10.14 BDNF CRH GNRH1 IL1B IL2 INS
4 cardiovascular system MP:0005385 10.13 CRHR1 HTR1A IL1B IL2 INS MAOA
5 endocrine/exocrine gland MP:0005379 10.13 BDNF CRH CRHR1 GNRH1 HTR2A IL2
6 nervous system MP:0003631 10.07 BDNF CRH CRHR1 GNRH1 HTR1A HTR7
7 digestive/alimentary MP:0005381 10 BDNF GNRH1 HTR2A IL2 INS NPY
8 integument MP:0010771 9.97 BDNF CRH GNRH1 HTR7 IL1B INS
9 no phenotypic analysis MP:0003012 9.76 BDNF CRH CRHR1 HTR1A IL2 INS
10 normal MP:0002873 9.56 BDNF CRH CRHR1 GNRH1 INS NPY
11 skeleton MP:0005390 9.23 CRH GNRH1 HTR2A IL1B INS NPY
Sources

Drugs & Therapeutics for Endogenous Depression

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Drugs for Endogenous Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational 58-61-7 60961
2 Vasodilator Agents
3 Analgesics
4 Anti-Arrhythmia Agents
5 Neurotransmitter Agents
6 Peripheral Nervous System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Quality of Life in Freeman-Sheldon Syndrome and Related Conditions Terminated NCT01307475

Search NIH Clinical Center for Endogenous Depression

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: depressive disorder

Sources

Genetic Tests for Endogenous Depression

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Sources

Anatomical Context for Endogenous Depression

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MalaCards organs/tissues related to Endogenous Depression:

41
Testes, Brain, Pituitary, Heart, Cortex, Thyroid, Bone
Sources

Publications for Endogenous Depression

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Articles related to Endogenous Depression:

(show top 50) (show all 1024)
# Title Authors Year
1
Treatment effectiveness and tolerability outcomes that are most important to individuals with bipolar and unipolar depression. ( 30241026 )
2019
2
Childhood maltreatment and adult medical morbidity in mood disorders: comparison of unipolar depression with bipolar disorder. ( 30232950 )
2018
3
Red Blood Cells Parameters in Patients with Acute Schizophrenia, Unipolar Depression and Bipolar Disorder. ( 30267525 )
2018
4
Correlation of proinflammatory cytokines levels and reduced gray matter volumes between patients with bipolar disorder and unipolar depression. ( 30359810 )
2018
5
Artistic creativity and risk for schizophrenia, bipolar disorder and unipolar depression: a Swedish population-based case-control study and sib-pair analysis. ( 29697041 )
2018
6
Patterns and predictors of conversion to bipolar disorder in 91 587 individuals diagnosed with unipolar depression. ( 29498031 )
2018
7
Factors That Impact Treatment Decisions: Results From an Online Survey of Individuals With Bipolar and Unipolar Depression. ( 30444959 )
2018
8
Frequency of use and perceived helpfulness of wellness strategies for bipolar and unipolar depression. ( 30372507 )
2018
9
Amygdala Activation and Connectivity to Emotional Processing Distinguishes Asymptomatic Patients With Bipolar Disorders and Unipolar Depression. ( 30343134 )
2018
10
Motor activity patterns in acute schizophrenia and other psychotic disorders can be differentiated from bipolar mania and unipolar depression. ( 30312969 )
2018
11
A Randomized Controlled Pilot Study on Mindfulness-Based Cognitive Therapy for Unipolar Depression in Patients With Chronic Pain. ( 28252881 )
2018
12
Differentiating bipolar disorders from unipolar depression by applying the Brief Assessment of Cognition in Affective Disorders. ( 28826415 )
2018
13
Antidepressant combination versus antidepressants plus second-generation antipsychotic augmentation in treatment-resistant unipolar depression. ( 28906325 )
2018
14
Decreased Pretreatment Amygdalae Serotonin Transporter Binding in Unipolar Depression Remitters: A Prospective PET Study. ( 28935838 )
2018
15
Body composition does not affect serum levels of cathelicidin LL-37 in elderly women with unipolar depression. ( 28959904 )
2018
16
Low left amygdala volume is associated with a longer duration of unipolar depression. ( 29159580 )
2018
17
Attentional biases in patients suffering from unipolar depression: results of a dot probe task investigation. ( 29331850 )
2018
18
Alterations in peripheral fatty acid composition in bipolar and unipolar depression. ( 29336895 )
2018
19
Hippocampal shape alterations in healthy young women with familial risk for unipolar depression. ( 29367060 )
2018
20
Cognitive Impairment In Treatment-Naïve Bipolar II and Unipolar Depression. ( 29382902 )
2018
21
Shared and distinct regional homogeneity changes in bipolar and unipolar depression. ( 29466722 )
2018
22
A systematic review of measures of medication adherence in consumers with unipolar depression. ( 29526664 )
2018
23
Psychopathological and sociodemographic features in treatment-resistant unipolar depression versus bipolar depression: a comparative study. ( 29548306 )
2018
24
Comparison of guidelines for the treatment of unipolar depression: a focus on pharmacotherapy and neurostimulation. ( 29577229 )
2018
25
Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects. ( 29580768 )
2018
26
Differentiating between bipolar and unipolar depression in functional and structural MRI studies. ( 29601896 )
2018
27
Neural correlates of processing emotional prosody in unipolar depression. ( 29682814 )
2018
28
Inpatient Volume and Quality of Mental Health Care Among Patients With Unipolar Depression. ( 29695225 )
2018
29
A quantitative review on outcome-to-antidepressants in melancholic unipolar depression. ( 29702301 )
2018
30
Mortality in unipolar depression preceding and following chronic somatic diseases. ( 29761489 )
2018
31
A Comparative Study of Different EEG Reference Choices for Diagnosing Unipolar Depression. ( 29860588 )
2018
32
The association of duration and severity of disease with executive function: Differences between drug-naïve patients with bipolar and unipolar depression. ( 29909305 )
2018
33
Mortality in treatment-resistant unipolar depression: A register-based cohort study in Sweden. ( 29966932 )
2018
34
Effects of different endurance exercise modalities on retinal vessel diameters in unipolar depression. ( 30048648 )
2018
35
Study supports augmentation with a non-antidepressant agent over combining or switching antidepressants in unipolar depression. ( 30054446 )
2018
36
Effects of Magnesium Supplementation on Unipolar Depression: A Placebo-Controlled Study and Review of the Importance of Dosing and Magnesium Status in the Therapeutic Response. ( 30081500 )
2018
37
Differential response to lithium between melancholic and non-melancholic unipolar depression. ( 30149276 )
2018
38
Consumer-related factors influencing antidepressant adherence in unipolar depression: a qualitative study. ( 30288027 )
2018
39
Language bias and comprehensive meta-analysis of folate for unipolar depression. ( 30293526 )
2018
40
Electroconvulsive therapy in unipolar depression treatment guidelines. ( 30295322 )
2018
41
Brief Social Isolation in the Adolescent Wistar-Kyoto Rat Model of Endogenous Depression Alters Corticosterone and Regional Monoamine Concentrations. ( 28233145 )
2017
42
Immediate and delayed anxiety- and depression-like profiles in the adolescent Wistar-Kyoto rat model of endogenous depression following postweaning social isolation. ( 28017851 )
2017
43
C-reactive protein as a differential biomarker of bipolar versus unipolar depression: Response. ( 27587356 )
2017
44
Adaptive emotion regulation mediates the relationship between self-compassion and depression in individuals with unipolar depression. ( 27743450 )
2017
45
Altered Brain Activity in Unipolar Depression Revisited: Meta-analyses of Neuroimaging Studies. ( 27829086 )
2017
46
Consistency, Replication, and Meta-analyses of Altered Brain Activity in Unipolar Depression. ( 27829090 )
2017
47
Evidence-based pharmacotherapy of treatment-resistant unipolar depression. ( 27848269 )
2017
48
Progression from unipolar depression to schizophrenia. ( 27858959 )
2017
49
Lithium, suicide prevention and unipolar depression? ( 27920059 )
2017
50
Augmentation of phenelzine with aripiprazole and quetiapine in a treatment-resistant patient with psychotic unipolar depression: case report and literature review. ( 28004621 )
2017
Sources

Variations for Endogenous Depression

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Copy number variations for Endogenous Depression from CNVD:

7 (show all 23)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 30014 1 239103312 239231293 Duplication RGS7 Depressive disorder
2 46482 10 81631178 81930681 Duplication ANXA11 Depressive disorder
3 46483 10 81631178 81930681 Duplication C10orf57 Depressive disorder
4 46484 10 81631178 81930681 Duplication PLAC9 Depressive disorder
5 46485 10 81631178 81930681 Duplication SFTPD Depressive disorder
6 49583 11 108105203 108301884 Duplication DDX10 Depressive disorder
7 96990 15 97399748 97770838 Duplication LRRC28 Depressive disorder
8 96991 15 97399748 97770838 Duplication TTC23 Depressive disorder
9 188464 4 65074807 68777792 Duplication CENPC1 Depressive disorder
10 188465 4 65074807 68777792 Duplication EPHA5 Depressive disorder
11 188466 4 65074807 68777792 Duplication GNRHR Depressive disorder
12 188467 4 65074807 68777792 Duplication STAP1 Depressive disorder
13 188468 11 117276569 117305325 Duplication TMPRSS11 Depressive disorder
14 188469 4 65074807 68777792 Duplication UBA6 Depressive disorder
15 192627 5 115261015 115369537 Duplication AP3S1 Depressive disorder
16 196524 5 168423758 169070607 Duplication CCDC99 Depressive disorder
17 196525 5 168423758 169070607 Duplication DOCK2 Depressive disorder
18 196526 5 168423758 169070607 Duplication SLIT3 Depressive disorder
19 198486 5 25121416 25298271 Duplication CDH10 Depressive disorder
20 223205 7 17201925 17473214 Duplication AHR Depressive disorder
21 223742 7 24922773 25040936 Duplication OSBPL3 Depressive disorder
22 228816 7 8241584 8363438 Duplication ICA1 Depressive disorder
23 237111 8 21188347 21318056 Duplication GFRA2 Depressive disorder
Sources

Expression for Endogenous Depression

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Search GEO for disease gene expression data for Endogenous Depression.
Sources

Pathways for Endogenous Depression

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Pathways related to Endogenous Depression according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 66
Show member pathways
 13.93 CRH CRHR1 GNRH1 HTR1A HTR2A HTR7
2
Peptide ligand-binding receptors 66
Show member pathways
 13.18 CRH CRHR1 GNRH1 HTR1A HTR2A HTR7
3
CREB Pathway 64
Show member pathways
 13.13 BDNF GNRH1 HTR1A HTR2A HTR7 IL2
4
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.03 BDNF GNRH1 IL1B IL2
6
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.87 BDNF GNRH1 IL1B IL2
7
Spinal Cord Injury 1
11.79 BDNF IL1B IL2
8
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.77 BDNF HTR1A HTR2A IL1B MAOA NR3C1
9
Monoamine GPCRs 1
Show member pathways
 11.75 HTR1A HTR2A HTR7
10
Serotonergic synapse 37
11.69 HTR1A HTR2A HTR7 MAOA SLC6A4 TPH1
11
Corticotropin-releasing hormone signaling pathway 1
11.62 CRH CRHR1 IL2
12
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.48 BDNF IL1B IL2
13
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.38 IL1B IL2 NR3C1
14
Monoamine Transport 1
Show member pathways
 11.13 IL1B MAOA SLC6A4
15
Biogenic Amine Synthesis 1
Show member pathways
 10.92 MAOA TPH1
16
Serotonin Receptor 4/6/7 and NR3C Signaling 1
10.83 HTR7 NR3C1
17
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.55 HTR1A HTR2A HTR7 MAOA SLC6A4 TPH1
18
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 61
10.28 CRH CRHR1
Sources

GO Terms for Endogenous Depression

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Cellular components related to Endogenous Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 BDNF CRH GNRH1 IL1B IL2 INS
2 extracellular region GO:0005576 9.56 BDNF CRH GNRH1 IL1B IL2 INS
3 dendrite GO:0030425 9.02 BDNF GNRH1 HTR1A HTR2A HTR7

Biological processes related to Endogenous Depression according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.99 CRH HTR1A HTR2A IL1B IL2 INS
2 response to drug GO:0042493 9.9 CRH HTR2A IL1B SLC6A4
3 chemical synaptic transmission GO:0007268 9.83 CRH HTR1A HTR2A HTR7 NPY
4 response to organic cyclic compound GO:0014070 9.8 GNRH1 IL1B TRH
5 cell-cell signaling GO:0007267 9.8 GNRH1 IL1B IL2 INS TRH
6 female pregnancy GO:0007565 9.77 CRH CRHR1 GNRH1
7 circadian rhythm GO:0007623 9.76 HTR7 SLC6A4 TPH1
8 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.7 HTR1A HTR2A HTR7
9 memory GO:0007613 9.67 BDNF HTR2A IL1B SLC6A4
10 response to immobilization stress GO:0035902 9.63 CRH IL1B TPH1
11 positive regulation of glycolytic process GO:0045821 9.62 HTR2A INS
12 positive regulation of kinase activity GO:0033674 9.62 HTR2A IL2
13 response to corticosterone GO:0051412 9.61 CRH TRH
14 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B INS
15 parturition GO:0007567 9.58 CRH CRHR1
16 behavior GO:0007610 9.57 HTR1A HTR2A
17 serotonin receptor signaling pathway GO:0007210 9.56 HTR1A HTR2A
18 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.56 HTR1A HTR2A HTR7 NPY
19 negative regulation of feeding behavior GO:2000252 9.55 INS TRH
20 response to ethanol GO:0045471 9.55 CRH GNRH1 IL1B IL2 TRH
21 negative regulation of glutamate secretion GO:0014050 9.54 IL1B TRH
22 vasoconstriction GO:0042310 9.5 HTR1A HTR7 SLC6A4
23 regulation of signaling receptor activity GO:0010469 9.5 BDNF GNRH1 IL1B IL2 INS NPY
24 regulation of serotonin secretion GO:0014062 9.49 CRH HTR1A
25 G protein-coupled receptor signaling pathway GO:0007186 9.32 CRH CRHR1 GNRH1 HTR1A HTR2A HTR7
26 signal transduction GO:0007165 10.13 CRH CRHR1 GNRH1 HTR1A HTR2A HTR7

Molecular functions related to Endogenous Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.43 HTR1A HTR2A HTR7
2 G protein-coupled serotonin receptor activity GO:0004993 9.33 HTR1A HTR2A HTR7
3 serotonin binding GO:0051378 9.13 HTR1A HTR2A SLC6A4
4 hormone activity GO:0005179 9.02 CRH GNRH1 INS NPY TRH
Sources

Sources for Endogenous Depression

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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