Aliases & Classifications for Endogenous Depression

MalaCards integrated aliases for Endogenous Depression:

Name: Endogenous Depression 12 15 71
Unipolar Depression 12 15 71
Clinical Depression 12 54 71
Depressive Disorder 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1595
MeSH 43 D003866
SNOMED-CT 67 300706003
UMLS 71 C0011573 C0011581 C0041696 more

Summaries for Endogenous Depression

Disease Ontology : 12 A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system.

MalaCards based summary : Endogenous Depression, also known as unipolar depression, is related to postpartum depression and depression, and has symptoms including depressed - symptom An important gene associated with Endogenous Depression is MAOA (Monoamine Oxidase A), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. The drugs Parathyroid hormone and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 74 Endogenous depression (melancholia) is an atypical sub-class of the mood disorder, major depressive... more...

Related Diseases for Endogenous Depression

Diseases related to Endogenous Depression via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 617)
# Related Disease Score Top Affiliating Genes
1 postpartum depression 31.9 SLC6A4 OXT NR3C1 MAOA LIPA HTR1A
2 depression 31.4 TPH1 SLC6A4 MAOA HTR2A HTR1A CRHR1
3 bipolar i disorder 31.3 SLC6A4 HTR2A HTR1A BDNF
4 schizoaffective disorder 31.2 SLC6A4 INS HTR2A HTR1A BDNF
5 major depressive disorder 31.1 TPH1 SLC6A4 OXT NR3C1 NPY MAOA
6 melancholia 31.0 SLC6A4 MAOA HTR2A HTR1A CRH BDNF
7 sexual disorder 30.9 SLC6A4 OXT INS HTR3A HTR2A HTR1A
8 antisocial personality disorder 30.8 SLC6A4 MAOA HTR2A
9 somatization disorder 30.7 SLC6A4 OXT HTR2A CRH
10 adjustment disorder 30.7 SLC6A4 NPY HTR2A HTR1A BDNF
11 temporal lobe epilepsy 30.7 NPY IL1B HTR1A BDNF
12 paine syndrome 30.7 IL1B HTR3A BDNF
13 neurotic disorder 30.7 SLC6A4 MAOA HTR2A HTR1A BDNF
14 diabetes insipidus 30.6 OXT INS CRH
15 phobia, specific 30.6 SLC6A4 OXT MAOA HTR1A CRH
16 eating disorder 30.6 SLC6A4 NPY HTR2A CRH BDNF
17 conduct disorder 30.6 TPH1 SLC6A4 MAOA
18 diarrhea 30.5 TPH1 SLC6A4 IL2 IL1B HTR3A HTR1A
19 social phobia 30.5 SLC6A4 OXT MAOA HTR3A HTR1A BDNF
20 hyperprolactinemia 30.5 TRH INS HTR2A GNRH1
21 psychotic disorder 30.5 TPH1 SLC6A4 OXT MAOA HTR3A HTR2A
22 amenorrhea 30.5 TRH INS GNRH1 CRH
23 paranoid schizophrenia 30.5 TPH1 SLC6A4 MAOA HTR2A HTR1A BDNF
24 substance dependence 30.5 TPH1 SLC6A4 MAOA CRHR1 CRH BDNF
25 somatoform disorder 30.5 TPH1 SLC6A4 IL1B HTR3A CRH BDNF
26 substance abuse 30.5 SLC6A4 NPY MAOA INS HTR2A HTR1A
27 amnestic disorder 30.4 HTR3A HTR1A CREB1 BDNF
28 acquired immunodeficiency syndrome 30.4 NR3C1 IL2 IL1B CRH
29 avoidant personality disorder 30.3 TPH1 SLC6A4 MAOA
30 body dysmorphic disorder 30.3 SLC6A4 OXT MAOA HTR2A
31 dissociative disorder 30.3 SLC6A4 OXT HTR2A BDNF
32 opiate dependence 30.3 TPH1 SLC6A4 CRH CREB1
33 pulmonary disease, chronic obstructive 30.3 SLC6A4 NR3C1 INS IL1B
34 thyroiditis 30.3 TRH INS IL2
35 withdrawal disorder 30.3 HTR1A CRHR1 CRH
36 attention deficit-hyperactivity disorder 30.3 TPH1 SLC6A4 OXT NR3C1 NPY MAOA
37 alexithymia 30.2 SLC6A4 OXT HTR1A
38 craniopharyngioma 30.2 TRH INS GNRH1
39 vitiligo-associated multiple autoimmune disease susceptibility 1 30.2 NPY MAOA IL2
40 complex regional pain syndrome 30.2 NPY IL2 IL1B CRHR1
41 hyperandrogenism 30.2 NR3C1 INS GNRH1
42 diabetes mellitus, type i 30.2 TRH NPY INS IL2 IL1B
43 kleptomania 30.2 SLC6A4 MAOA HTR1A
44 serotonin syndrome 30.2 SLC6A4 OXT MAOA HTR3A HTR2A HTR1A
45 atypical depressive disorder 30.2 SLC6A4 NR3C1 MAOA HTR2A HTR1A CRHR1
46 panic disorder 30.2 TRH TPH1 SLC6A4 NPY MAOA HTR3A
47 drug dependence 30.2 SLC6A4 NPY HTR3A CRHR1 CRH BDNF
48 apnea, obstructive sleep 30.1 INS IL1B HTR2A
49 fragile x syndrome 30.1 SLC6A4 MAOA CRHR1 BDNF
50 heroin dependence 30.1 SLC6A4 MAOA BDNF

Graphical network of the top 20 diseases related to Endogenous Depression:



Diseases related to Endogenous Depression

Symptoms & Phenotypes for Endogenous Depression

UMLS symptoms related to Endogenous Depression:


depressed - symptom

MGI Mouse Phenotypes related to Endogenous Depression:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.48 BDNF CREB1 CRH CRHR1 HTR1A HTR2A
2 homeostasis/metabolism MP:0005376 10.43 BDNF CREB1 CRH CRHR1 GNRH1 HTR1A
3 endocrine/exocrine gland MP:0005379 10.39 BDNF CREB1 CRH CRHR1 GNRH1 HTR2A
4 growth/size/body region MP:0005378 10.37 BDNF CREB1 CRH GNRH1 HTR3A IL1B
5 cardiovascular system MP:0005385 10.35 CREB1 CRHR1 HTR1A IL1B IL2 INS
6 nervous system MP:0003631 10.27 BDNF CREB1 CRH CRHR1 GNRH1 HTR1A
7 digestive/alimentary MP:0005381 10.26 BDNF GNRH1 HTR2A IL2 INS LIPA
8 integument MP:0010771 10.23 BCL2A1 BDNF CRH GNRH1 HTR3A IL1B
9 mortality/aging MP:0010768 10.22 BCL2A1 BDNF CREB1 CRHR1 HTR1A HTR3A
10 adipose tissue MP:0005375 10.1 CRH INS LIPA NPY NR3C1 OXT
11 liver/biliary system MP:0005370 9.98 CRH GNRH1 IL2 INS LIPA NPY
12 no phenotypic analysis MP:0003012 9.92 BDNF CRH CRHR1 HTR1A IL2 INS
13 normal MP:0002873 9.91 BDNF CREB1 CRH CRHR1 GNRH1 INS
14 renal/urinary system MP:0005367 9.81 CRH GNRH1 HTR3A INS LIPA NPY
15 respiratory system MP:0005388 9.56 BDNF CREB1 CRH CRHR1 IL2 LIPA
16 skeleton MP:0005390 9.32 CREB1 CRH GNRH1 HTR2A IL1B INS

Drugs & Therapeutics for Endogenous Depression

Drugs for Endogenous Depression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 597)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3
Ropinirole Approved, Investigational Phase 4 91374-20-8, 91374-21-9 497540 5095
4
Reboxetine Approved, Experimental Phase 4 98769-81-4, 71620-89-8 123628 65856
5
Oxcarbazepine Approved Phase 4 28721-07-5 34312
6
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
7
Amitriptyline Approved Phase 4 50-48-6 2160
8
Nortriptyline Approved Phase 4 72-69-5 4543
9
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
10
Memantine Approved, Investigational Phase 4 19982-08-2 4054
11
Ziprasidone Approved Phase 4 146939-27-7 60854
12
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
13
Brexpiprazole Approved, Investigational Phase 4 913611-97-9 11978813
14
Methohexital Approved Phase 4 151-83-7 9034
15
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
16
Propranolol Approved, Investigational Phase 4 525-66-6 4946
17
Desipramine Approved, Investigational Phase 4 50-47-5 2995
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
20
Methyltestosterone Approved Phase 4 58-18-4 6010
21
Moclobemide Approved, Investigational Phase 4 71320-77-9 4235
22
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
23
Iloperidone Approved Phase 4 133454-47-4 71360
24
Terazosin Approved Phase 4 63590-64-7 5401
25
Zolpidem Approved Phase 4 82626-48-0 5732
26
Haloperidol Approved Phase 4 52-86-8 3559
27
Calcium carbonate Approved, Investigational Phase 4 471-34-1
28
Acamprosate Approved, Investigational Phase 4 77337-76-9 71158
29
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
30
Methadone Approved Phase 4 76-99-3 4095
31
Ribavirin Approved Phase 4 36791-04-5 37542
32
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
33
Medroxyprogesterone acetate Approved, Investigational Phase 4 71-58-9
34
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
35
Protriptyline Approved Phase 4 438-60-8 4976
36
Trimipramine Approved Phase 4 739-71-9 5584 4055
37
Topiramate Approved Phase 4 97240-79-4 5284627
38
Isocarboxazid Approved Phase 4 59-63-2 3759
39
Maprotiline Approved, Investigational Phase 4 10262-69-8 4011
40
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
41
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
42
Donepezil Approved Phase 4 120014-06-4 3152
43
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
44
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
45
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
46
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
47
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
48
Metyrapone Approved, Investigational Phase 4 54-36-4 4174
49
Suvorexant Approved, Investigational Phase 4 1030377-33-3
50
Metformin Approved Phase 4 657-24-9 14219 4091

Interventional clinical trials:

(show top 50) (show all 4250)
# Name Status NCT ID Phase Drugs
1 Exploring Alterations of Central Autonomic Modulation in Patients With Bipolar Depression Unknown status NCT01213121 Phase 4 Quetiapine
2 THE AIUNI - Integral Assessment in Unipolar Depression Unknown status NCT02268487 Phase 4 Sertraline
3 Phase 4 Study of Vitamin D3 Supplementation for Outcomes in Patients With Unipolar Depression Unknown status NCT01390662 Phase 4
4 Phase 4 Study of Escitalopram Treatment and Biomarkers in Major Depressive Disorder Unknown status NCT01997580 Phase 4 escitalopram
5 The Effect and Reliability of Escitalopram in the Treatment of Adolescents With Major Depressive Disorder or Anxiety Disorders Unknown status NCT03122158 Phase 4 Escitalopram
6 Role of Inflammation Factors and Insulin Resistance in the Pathophysiology and Treatment Response of Major Depressive Disorder Unknown status NCT01699490 Phase 4 Fluoxetine + Valsartan;Fluoxetine + Placebo
7 Vortioxetine Versus Placebo in Major Depressive Disorder Comorbid With Social Anxiety Disorder Unknown status NCT02294305 Phase 4 Vortioxetine;Placebo
8 Pharmacogenomics Studies of Antidepressants Unknown status NCT01204086 Phase 4 Venlafaxine;Fluoxetine
9 Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder Unknown status NCT02051413 Phase 4 Venlafaxine extended release
10 Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder Unknown status NCT01460212 Phase 4 SSRI antidepressants
11 Clinical Trial of the Use of Ketamine in Treatment Resistant Depression Unknown status NCT02610712 Phase 4 Ketamine
12 Randomized,Controlled and Open-label Study of Buspirone add-on Treatment in Patients With Major Depression Disorder Unknown status NCT02273154 Phase 4 Buspirone;Paroxetine
13 Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression Unknown status NCT00291239 Phase 4
14 Escitalopram and Sleep Architecture in Patients With Major Depressive Disorder Unknown status NCT00442481 Phase 4 Escitalopram
15 Effect of Escitalopram vs. Reboxetine on Somatic and Visceral Sensitivity of Patients With Major Depressive Disorder: a Randomized, Double Blind Clinical Trial Unknown status NCT00209807 Phase 4 escitalopram;Reboxetine
16 A Dimensional Approach to Evaluate Reward Processing in Major Depressive Disorder Before and After Treatment With Desvenlafaxine Unknown status NCT02859103 Phase 4 Desvenlafaxine
17 Turgut Ozal Medical Center Department of Anesthesiology and Reanimation Unknown status NCT02267980 Phase 4 Sevoflurane;Ketamine;Saline
18 Inflammatory Markers and Cognitive Function in Major Depression:a Pilot Study Unknown status NCT01391221 Phase 4 Duloxetine
19 Duloxetine for the Treatment of Major Depression in Midlife Women: Effects on Brain Structure and Functioning, Mood, and Quality of Life Unknown status NCT00889369 Phase 4 Duloxetine
20 Hyperventilation and ECT Seizure Duration: Effects on Cerebral Oxygen Saturation, and Therapeutic Outcome With Comparisons Between Etomidate and Ketamine in Patients With Major Depressive Disorder Unknown status NCT02924090 Phase 4 Etomidate;Ketamine
21 Algorithm Guided Treatment Strategies for Major Depressive Disorder Unknown status NCT01764867 Phase 4 Escitalopram;Mirtazapine;Fluoxetine;Citalopram;Escitalopram;Paroxetine;Sertraline;Fluvoxamine;Venlafaxine;Duloxetine;Mirtazapine;Bupropion;Trazodone
22 A Randomised Trial Investigating the Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder. Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
23 A Placebo Controlled Trial of the Dopamine D-2 Receptor Agonist Ropinirole in Treatment of 60 Patients With Refractory Bipolar I and II Depression. Unknown status NCT00335205 Phase 4 ropinirole
24 Escitalopram Treatment of Major Depression in Diabetes Mellitus: An Open Label Unknown status NCT00650897 Phase 4 Escitalopram
25 White Matter Structure and Response to Treatment With Antidepressants: a Study of Desvenlafaxine in Major Depression. A Pilot Study Unknown status NCT01492621 Phase 4 Desvenlafaxine
26 The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope Unknown status NCT01357967 Phase 4 SSRI monotherapy;Seroquel XR adjunctive
27 Evaluation of the Efficacy of Repetitive Transcranial Magnetic Stimulation on Cognitive, Anxiety and Depressive Symptoms in Patients Diagnosed With Major Depressive Disorder Unknown status NCT02213016 Phase 4
28 A Randomized Controlled Study Comparing Fluoxetine With Bupropion for Impulsivity and Suicidality in Patients With Major Depressive Disorder and Comorbid Alcoholism (Abuse or Dependence) Unknown status NCT00449007 Phase 4 fluoxetine;bupropion
29 A Comparative Trial of TMS Approaches to Treating Depression Unknown status NCT01906905 Phase 4
30 Sequence Towards Remission in Depression Unknown status NCT01628783 Phase 4 escitalopram 10 mg;Placebo
31 Exploratory Study to Assess the Efficacy of Escitalopram Versus Placebo in the Treatment of Depressive Syndrome in Alzheimer’s Disease, Vascular Dementia and Mixed Vascular and Alzheimer’s Dementia Unknown status NCT00229333 Phase 4 Escitalopram
32 Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT") Unknown status NCT00226642 Phase 4 Sertralin;Placebo
33 Brain Mechanisms and Targeting Insomnia in Major Depression Unknown status NCT00628914 Phase 4 escitalopram and eszopiclone;Escitalopram, eszopiclone, and placebo;Escitalopram
34 Hippocampal Volume in Young Patients With Major Depression Before and After Combined Antidepressive Therapy - a Monocentric, Double-Blind, Placebo-Controlled Trial Unknown status NCT00150839 Phase 4 Mirtazapine;Venlafaxine
35 Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child Unknown status NCT01796132 Phase 4 SSRI/SNRI
36 Neurochemical,Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder Unknown status NCT02346682 Phase 4 venlafaxine
37 Clinical Psychopharmacology Division Institute of Mental Health, Peking University Unknown status NCT03148509 Phase 4 risperidone;aripiprazole;bupropion
38 Integrated Smoking Cessation Treatment for Smokers With Serious Mental Illness Unknown status NCT02845440 Phase 4
39 TMSFOS: Preliminary Study to Investigate the Effect of rTMS and SSRI Antidepressants on Leukocyte Expression of the C-FOS and DUSP1 Genes in Patients Treated for Depression Unknown status NCT02042573 Phase 4 SSRI (SEROPLEX ou ZOLOFT)
40 An Exploratory Randomized Open Comparison of Oxtellar XR® vs Oxcarbazepine IR (Trileptal®) for the Treatment of Bipolar Depression Unknown status NCT03567681 Phase 4 Extended release oxcarbazepine vs Immediate release oxcarbazepine
41 Treatment Prediction in Adolescent and Adult Depression Unknown status NCT00106197 Phase 4 Bupropion
42 A Double-Blind, Placebo-Controlled Study of Escitalopram in the Prevention of Depression in Patients With Acute Coronary Syndrome Unknown status NCT00140257 Phase 4 Escitalopram
43 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
44 a Randomized, Double Blind, Placebo-controlled, Multicenter Clinical Trial of Efficacy and Safety of Shu Gan yi Yang Capsule in the Treatment of Depression Associated With Erectile Dysfunction (Stagnation of Liver qi and Kidney Deficiency) Unknown status NCT03290313 Phase 4 shu gan yi yang capsule;shu gan yi yang capsule simulation agent
45 Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy Unknown status NCT02579642 Phase 4 Ketamine;Placebo
46 Prediction of Individual Treatment Response Based on Brain Changes at the Early Phase of Antidepressant Treatment in Major Depressive Disorder Using Machine Learning Classification Analysis Unknown status NCT02330679 Phase 4 Desvenlafaxine;Placebo
47 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
48 Collaborative Care for Depressed Elders in China Unknown status NCT01287494 Phase 4 Sertraline
49 A Multicenter, Double Blind Trial to Compare the Efficacy and Safety of Escitalopram With Placebo in Patients With Acute Stroke for the Prevention of Poststroke Depression and Related Symptoms (Emotional Incontinence, Anger Proneness), and for Improvement of Neurologic, Cognitive Function and Quality of Life Unknown status NCT01278498 Phase 4 Escitalopram;sugar pill
50 Group Mindfulness-Based Cognitive Therapy for the Treatment of Late-Life Depression and Anxiety Symptoms in Primary Care: A Randomized Controlled Trial Unknown status NCT02777905 Phase 4

Search NIH Clinical Center for Endogenous Depression

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Alprazolam
Amitriptyline
Amitriptyline Hydrochloride
Amoxapine
Bupropion
Bupropion hydrobromide
Bupropion Hydrochloride
Buspirone
buspirone hydrochloride
Citalopram
Citalopram hydrobromide
Clomipramine
Clomipramine Hydrochloride
Desipramine
Desipramine Hydrochloride
Doxepin
Doxepin Hydrochloride
Escitalopram
Escitalopram oxalate
Fluoxetine
Fluoxetine Hydrochloride
Fluvoxamine
Fluvoxamine Maleate
HYPERICUM PERFORATUM (ST. JOHN'S WORT)
Imipramine
Imipramine Hydrochloride
Imipramine pamoate
Isocarboxazid
Isoflurane
Kava preparation
Lithium
Lithium Aspartate
Lithium Carbonate
lithium citrate
Lorazepam
Maprotiline
Maprotiline Hydrochloride
Methylphenidate
Methylphenidate Hydrochloride
Mirtazapine
nefazodone
Nortriptyline
Nortriptyline Hydrochloride
Paroxetine
Paroxetine Hydrochloride
Phenelzine
Phenelzine Sulfate
Pramipexole
Pramipexole dihydrochloride
Protriptyline
Protriptyline Hydrochloride
Selegiline
selegiline hydrochloride
Sertraline
Sertraline Hydrochloride
Temazepam
Tranylcypromine
Tranylcypromine sulfate
Trazodone
Trazodone Hydrochloride
Tricyclic Antidepressant [EPC]
Trimipramine
Trimipramine Maleate
venlafaxine
Venlafaxine hydrochloride

Cochrane evidence based reviews: depressive disorder

Genetic Tests for Endogenous Depression

Anatomical Context for Endogenous Depression

MalaCards organs/tissues related to Endogenous Depression:

40
Brain, Testes, Heart, Cortex, Prefrontal Cortex, Breast, Pituitary

Publications for Endogenous Depression

Articles related to Endogenous Depression:

(show top 50) (show all 4224)
# Title Authors PMID Year
1
Different effects of pyridostigmine on the thyrotropin response to thyrotropin-releasing hormone in endogenous depression and subclinical thyrotoxicosis. 54 61
9440477 1998
2
Neuroendocrine aspects of primary endogenous depression. X: Serum growth hormone measures in patients and matched control subjects. 54 61
2111183 1990
3
Beta-lipotropin-beta-endorphin response to low-dose ovine corticotropin releasing factor in endogenous depression. Preliminary studies. 54 61
2139563 1990
4
Chronotype, circadian rhythms and mood. 61
31786494 2020
5
Predicting treatment effects in unipolar depression: A meta-review. 61
32437828 2020
6
Rate of diagnostic conversion to bipolar disorder in adults with unipolar depression and psychopharmacological treatment in the republic of Korea: A nationwide register-based study. 61
32421610 2020
7
Childhood abuse and intimate partner violence among women with mood disorders. 61
32553375 2020
8
The Role of Emotion Regulation on Co-occurring Psychopathology in Emerging Adults with ASD. 61
30875017 2020
9
Intermittent theta-burst stimulation moderates interaction between increment of N-Acetyl-Aspartate in anterior cingulate and improvement of unipolar depression. 61
32380445 2020
10
The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences. 61
32145362 2020
11
Suicidal ideation and attempts in unipolar versus bipolar depression: analysis of 131,740 adolescent inpatients nationwide. 61
32574899 2020
12
A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy. 61
32529966 2020
13
Patients' and providers' experiences with video consultations used in the treatment of older patients with unipolar depression: A systematic review. 61
31677331 2020
14
When and how to use Lithium. 61
32526812 2020
15
Therapeutic Alliance in Technology-Based Interventions for the Treatment of Depression: Systematic Review. 61
32525484 2020
16
Reimagining the Spectrum of Affective Disorders. 61
32557983 2020
17
Serum nesfatin-1, ghrelin, and lipid levels in adolescents with first episode drug naïve unipolar depression. 61
32496844 2020
18
A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression. 61
30874608 2020
19
Latent class analysis of bipolar disorder symptoms and suicidal ideation and behaviors. 61
32579284 2020
20
A specific group of patients with diagnostic conversion from depression to bipolar disorder and finally to dementia as a mental GSK-3 disease: A hypothesis. 61
31742842 2020
21
Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials. 61
31965454 2020
22
Using network analysis to explore cognitive domains in patients with unipolar versus bipolar depression: a prospective naturalistic study. 61
31060642 2020
23
Effects of antidepressant medicines on preventing relapse of unipolar depression: a pooled analysis of parametric survival curves. 61
32501194 2020
24
Identification of Common Neural Circuit Disruptions in Emotional Processing Across Psychiatric Disorders. 61
31964160 2020
25
The Effect of Pulse Width on Subjective Memory Impairment and Remission Rate 6 Months After Electroconvulsive Therapy. 61
32453190 2020
26
Depressive symptom trajectories associated with standard and accelerated rTMS. 61
32289716 2020
27
Anterior cingulate cortex, insula and amygdala seed-based whole brain resting-state functional connectivity differentiates bipolar from unipolar depression. 61
32469830 2020
28
Gender- and age-related differences in the quality of mental health care among inpatients with unipolar depression: a nationwide study. 61
32401125 2020
29
Relationship between the core features of Tellenbach's Typus Melancholicus and unipolar depressive disorders: a cross-sectional study. 61
32489197 2020
30
Activity and subsequent depression levels: a causal analysis of behavioural activation group treatment with weekly assessments over 8 weeks. 61
31976588 2020
31
Development of the National Network of Depression Centers Mood Outcomes Program: A Multisite Platform for Measurement-Based Care. 61
31960777 2020
32
Predicting differential diagnosis between bipolar and unipolar depression with multiple kernel learning on multimodal structural neuroimaging. 61
32238313 2020
33
Pharmacological augmentation in unipolar depression: a guide to the guidelines. 61
32402075 2020
34
Personalise antidepressant treatment for unipolar depression combining individual choices, risks and big data (PETRUSHKA): rationale and protocol. 61
31645364 2020
35
Why are cardiovascular diseases more common among patients with severe mental illness? The potential involvement of electronegative low-density lipoprotein (LDL) L5. 61
32417641 2020
36
Diagnostic conversion from unipolar depression to bipolar disorder, schizophrenia, or schizoaffective disorder: A nationwide prospective 15-year register study on 43 495 inpatients. 61
32385906 2020
37
Prefrontal cortical activation during working memory task anticipation contributes to discrimination between bipolar and unipolar depression. 61
32069475 2020
38
Thyroid hormone treatment in the management of treatment-resistant unipolar depression: a systematic review and meta-analysis. 61
31977066 2020
39
Cost-utility analysis of curative and maintenance repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant unipolar depression: a randomized controlled trial protocol. 61
32248820 2020
40
Differential biomarker signatures in unipolar and bipolar depression: A machine learning approach. 61
31789053 2020
41
Smartteen- a computer assisted cognitive behavior therapy for Indian adolescents with depression- a pilot study. 61
32114331 2020
42
Alterations in levels of 8-Oxo-2'-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current episode and after remission in unipolar and bipolar depression. 61
32062372 2020
43
Depression Onset in Long-term Adolescent Cannabinoid Use: A Neurobiological Review. 61
32455076 2020
44
[Adult attention deficit hyperactivity disorder and comorbidity: new findings on epidemiological and genetic factors]. 61
32266439 2020
45
EAAT2 as a Research Target in Bipolar Disorder and Unipolar Depression: A Systematic Review. 61
32399469 2020
46
Adjunctive folate for major mental disorders: A systematic review. 61
32063563 2020
47
Quality of life in patients with severe mental illness: a cross-sectional survey in an integrated outpatient health care model. 61
32170584 2020
48
Electroconvulsive Therapy in Pregnancy: Safety, Best Practices, and Barriers to Care. 61
32232498 2020
49
Diagnosis, Clinical Features, and Therapeutic Implications of Agitated Depression 61
32008687 2020
50
A Review of Antidepressant-Associated Hypomania in Those Diagnosed with Unipolar Depression-Risk Factors, Conceptual Models, and Management. 61
32215771 2020

Variations for Endogenous Depression

Copy number variations for Endogenous Depression from CNVD:

7 (show all 23)
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 30014 1 239103312 239231293 Duplication RGS7 Depressive disorder
2 46482 10 81631178 81930681 Duplication ANXA11 Depressive disorder
3 46483 10 81631178 81930681 Duplication C10orf57 Depressive disorder
4 46484 10 81631178 81930681 Duplication PLAC9 Depressive disorder
5 46485 10 81631178 81930681 Duplication SFTPD Depressive disorder
6 49583 11 108105203 108301884 Duplication DDX10 Depressive disorder
7 96990 15 97399748 97770838 Duplication LRRC28 Depressive disorder
8 96991 15 97399748 97770838 Duplication TTC23 Depressive disorder
9 188464 4 65074807 68777792 Duplication CENPC1 Depressive disorder
10 188465 4 65074807 68777792 Duplication EPHA5 Depressive disorder
11 188466 4 65074807 68777792 Duplication GNRHR Depressive disorder
12 188467 4 65074807 68777792 Duplication STAP1 Depressive disorder
13 188468 11 117276569 117305325 Duplication TMPRSS11 Depressive disorder
14 188469 4 65074807 68777792 Duplication UBA6 Depressive disorder
15 192627 5 115261015 115369537 Duplication AP3S1 Depressive disorder
16 196524 5 168423758 169070607 Duplication CCDC99 Depressive disorder
17 196525 5 168423758 169070607 Duplication DOCK2 Depressive disorder
18 196526 5 168423758 169070607 Duplication SLIT3 Depressive disorder
19 198486 5 25121416 25298271 Duplication CDH10 Depressive disorder
20 223205 7 17201925 17473214 Duplication AHR Depressive disorder
21 223742 7 24922773 25040936 Duplication OSBPL3 Depressive disorder
22 228816 7 8241584 8363438 Duplication ICA1 Depressive disorder
23 237111 8 21188347 21318056 Duplication GFRA2 Depressive disorder

Expression for Endogenous Depression

Search GEO for disease gene expression data for Endogenous Depression.

Pathways for Endogenous Depression

Pathways related to Endogenous Depression according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 TRH OXT NR3C1 NPY INS IL2
2
Show member pathways
13.39 TRH OXT NR3C1 NPY HTR2A HTR1A
3
Show member pathways
13.16 IL2 HTR3A HTR2A HTR1A GNRH1 CREB1
4
Show member pathways
12.33 NR3C1 INS IL1B CREB1
5
Show member pathways
12.32 OXT IL1B CRHR1 CRH CREB1
7 12.05 OXT NPY HTR1A CREB1 BDNF
8 11.69 TPH1 SLC6A4 MAOA HTR3A HTR2A HTR1A
9 11.64 NR3C1 IL2 CREB1
10 11.64 IL2 CRHR1 CRH CREB1
11 11.53 TPH1 SLC6A4 NR3C1 MAOA IL1B HTR3A
12
Show member pathways
11.36 NR3C1 IL2 IL1B BCL2A1
13 11.31 NR3C1 INS CREB1
14
Show member pathways
11.29 SLC6A4 MAOA IL1B
15
Show member pathways
10.94 SLC6A4 MAOA HTR1A
16 10.88 TPH1 SLC6A4 MAOA HTR3A HTR2A HTR1A
17 10.7 CREB1 BDNF
18 10.36 CRHR1 CRH

GO Terms for Endogenous Depression

Cellular components related to Endogenous Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 TRH OXT NPY INS IL2 IL1B
2 extracellular space GO:0005615 10.01 OXT NPY INS IL2 IL1B GNRH1
3 synapse GO:0045202 9.8 SLC6A4 NPY HTR3A HTR2A HTR1A CRH
4 neuron projection GO:0043005 9.65 TPH1 SLC6A4 HTR3A GNRH1 CRHR1
5 integral component of presynaptic membrane GO:0099056 9.33 SLC6A4 HTR3A HTR2A
6 integral component of postsynaptic membrane GO:0099055 9.13 SLC6A4 HTR3A HTR2A
7 secretory granule GO:0030141 8.92 TRH OXT IL1B BDNF

Biological processes related to Endogenous Depression according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.97 INS IL2 IL1B HTR2A HTR1A CRH
2 response to drug GO:0042493 9.92 SLC6A4 HTR2A CRH CREB1 BDNF
3 aging GO:0007568 9.87 HTR2A GNRH1 CREB1 BCL2A1
4 chemical synaptic transmission GO:0007268 9.85 NPY HTR3A HTR2A HTR1A CRH
5 cell-cell signaling GO:0007267 9.8 TRH INS IL2 IL1B GNRH1
6 response to ethanol GO:0045471 9.78 IL2 HTR3A GNRH1 CRH
7 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.77 NPY HTR2A HTR1A
8 positive regulation of fat cell differentiation GO:0045600 9.75 TPH1 HTR2A CREB1
9 response to cocaine GO:0042220 9.72 OXT HTR3A CRH
10 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.69 IL2 IL1B BCL2A1
11 female pregnancy GO:0007565 9.67 OXT GNRH1 CRHR1 CRH
12 G protein-coupled receptor signaling pathway GO:0007186 9.65 TRH OXT NPY INS IL2 HTR2A
13 behavior GO:0007610 9.62 HTR2A HTR1A
14 circadian rhythm GO:0007623 9.62 TPH1 SLC6A4 CREB1 BDNF
15 sleep GO:0030431 9.61 OXT HTR2A
16 parturition GO:0007567 9.61 CRHR1 CRH
17 response to prostaglandin E GO:0034695 9.6 OXT GNRH1
18 positive regulation of prostaglandin secretion GO:0032308 9.58 OXT IL1B
19 sperm ejaculation GO:0042713 9.56 SLC6A4 OXT
20 memory GO:0007613 9.55 SLC6A4 OXT HTR2A CREB1 BDNF
21 response to ether GO:0045472 9.54 OXT CRH
22 signal transduction GO:0007165 9.44 TRH OXT NR3C1 INS IL1B HTR3A
23 regulation of serotonin secretion GO:0014062 9.43 HTR1A CRH
24 serotonin receptor signaling pathway GO:0007210 9.43 HTR3A HTR2A HTR1A

Molecular functions related to Endogenous Depression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurotransmitter receptor activity GO:0030594 9.43 HTR3A HTR2A HTR1A
2 hormone activity GO:0005179 9.43 TRH OXT NPY INS GNRH1 CRH
3 neuropeptide hormone activity GO:0005184 9.33 OXT NPY CRH
4 serotonin binding GO:0051378 8.92 SLC6A4 HTR3A HTR2A HTR1A

Sources for Endogenous Depression

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....