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MCID: END041
MIFTS: 60

Endometrial Adenocarcinoma

Categories: Reproductive diseases, Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endometrial Adenocarcinoma

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MalaCards integrated aliases for Endometrial Adenocarcinoma:

Name: Endometrial Adenocarcinoma 12 15 73
Endometrial Endometrioid Adenocarcinoma 12 73
Endometrial Adenoacanthoma 12 73
Endometrial Endometrioid Adenocarcinoma, Variant with Squamous Differentiation 6
Endometrial Endometrioid Adenocarcinoma with Squamous Differentiation 12
Endometrioid Carcinoma of Endometrium 12
Endometrioid Adenomas and Carcinomas 12
Adenocarcinoma of the Endometrium 12
Endometrioid Adenoma or Carcinoma 12
Adenocarcinoma of Endometrium 12
Adenocarcinoma of Uterus 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2870
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Summaries for Endometrial Adenocarcinoma

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Disease Ontology : 12 An endometrial carcinoma that derives from epithelial cells of glandular origin.

MalaCards based summary : Endometrial Adenocarcinoma, also known as endometrial endometrioid adenocarcinoma, is related to adenomyosis and adenocarcinoma in situ. An important gene associated with Endometrial Adenocarcinoma is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are ERK Signaling and Gene Expression. The drugs Bupivacaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include uterus, lymph node and endothelial, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Endometrial Adenocarcinoma

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Diseases related to Endometrial Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 31.2 ESR1 PGR VEGFA
2 adenocarcinoma in situ 30.7 CDKN2A KRAS KRT7
3 cervical squamous cell carcinoma 30.6 CDKN2A MKI67 TP53
4 endocervical adenocarcinoma 30.6 CDKN2A KRT7 TP53
5 endometriosis 30.4 ESR1 ESR2 PGR VEGFA
6 adenosarcoma 30.4 ESR1 MKI67 PGR TP53
7 endometriosis of ovary 30.4 ESR1 ESR2 PGR
8 papilloma 30.1 CDKN2A KRT7 PTEN TP53
9 papillary adenocarcinoma 30.0 ERBB2 KRT7 PGR TP53
10 wilms tumor 1 29.7 ERBB2 ESR1 KRAS PGR TP53
11 endometrial stromal sarcoma 29.3 ESR1 MALAT1 PGR TP53
12 hemangioma 29.3 FGF2 KRAS VEGFA
13 cervical adenocarcinoma 29.2 CDKN2A EGFR ERBB2 ESR1 KRT7 TP53
14 adenocarcinoma 28.6 AKT1 CDKN2A EGFR ERBB2 FGFR2 KRAS
15 gastrointestinal stromal tumor 28.3 AKT1 CDKN2A EGFR KRAS MKI67 PTEN
16 lung cancer susceptibility 3 26.6 AKT1 CDKN2A EGFR ERBB2 KRAS KRT7
17 squamous cell carcinoma 25.8 AKT1 CDKN2A EGFR ERBB2 FGFR2 KRAS
18 colorectal cancer 23.6 AKT1 CDKN2A CTSD EGFR ERBB2 ESR2
19 endometrial cancer 23.5 AKT1 CDKN2A CTSD EGFR ERBB2 ESR1
20 breast cancer 21.0 AKT1 CTSD EGFR ERBB2 ESR1 ESR2
21 villoglandular endometrial endometrioid adenocarcinoma 12.2
22 oxyphilic endometrial endometrioid adenocarcinoma 12.2
23 mucin-rich endometrial endometrioid adenocarcinoma 12.2
24 secretory uterine corpus endometrioid adenocarcinoma 11.2
25 sarcomatoid uterine corpus endometrioid adenocarcinoma 11.2
26 vulvar syringoma 11.0 ESR1 PGR
27 endometrium carcinoma in situ 11.0 PGR TP53
28 lung leiomyoma 11.0 ESR1 PGR
29 breast duct papilloma 11.0 PGR PTEN
30 vulvar benign neoplasm 11.0 ESR1 PGR
31 trigonitis 11.0 ESR1 PGR
32 vulvar leiomyoma 10.9 ESR1 PGR
33 brain stem astrocytic neoplasm 10.9 CDKN2A TP53
34 vestibular gland benign neoplasm 10.9 ESR1 PGR TP53
35 bartholin's gland adenoma 10.9 ESR1 PGR TP53
36 vulvar dystrophy 10.9 CDKN2A PGR
37 endometrial squamous cell carcinoma 10.9 CDKN2A ESR1 PGR
38 cervical carcinosarcoma 10.9 ESR1 PGR TP53
39 cervical clear cell adenocarcinoma 10.8 CDKN2A ESR1 PGR
40 inverted transitional papilloma 10.8 CDKN2A KRT7
41 cribriform carcinoma 10.8 ESR1 KRT7 PGR
42 scirrhous adenocarcinoma 10.8 ERBB2 PGR
43 mucinous stomach adenocarcinoma 10.8 PTEN VEGFA
44 breast apocrine carcinoma 10.8 ERBB2 PGR
45 papillary serous adenocarcinoma 10.8 KRT7 PGR TP53
46 endocervical carcinoma 10.7 CDKN2A ESR1 KRT7
47 pancreatic mucinous cystadenoma 10.7 ESR1 KRT7 PGR
48 corneal abscess 10.7 KRT7 PGR PTEN
49 predominantly cortical thymoma 10.7 ESR1 PGR
50 bladder carcinoma in situ 10.7 CDKN2A KRT7 TP53

Graphical network of the top 20 diseases related to Endometrial Adenocarcinoma:



Diseases related to Endometrial Adenocarcinoma
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Symptoms & Phenotypes for Endometrial Adenocarcinoma

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GenomeRNAi Phenotypes related to Endometrial Adenocarcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.3 KRAS EGFR
2 Decreased viability GR00106-A-0 10.3 KRAS
3 Decreased viability GR00221-A-1 10.3 ESR1 CDKN2A EGFR KRAS AKT1
4 Decreased viability GR00221-A-2 10.3 ESR1 KRAS AKT1
5 Decreased viability GR00221-A-3 10.3 CDKN2A ERBB2 AKT1
6 Decreased viability GR00221-A-4 10.3 ESR1 CDKN2A EGFR ERBB2 AKT1
7 Decreased viability GR00301-A 10.3 KRAS
8 Decreased viability GR00381-A-1 10.3 KRAS
9 Decreased viability GR00402-S-2 10.3 CDKN2A KRAS EGFR ERBB2 ESR1 AKT1
10 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.63 CTSD EGFR ERBB2 FGFR2 PTEN VEGFA
11 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 ESR1 ESR2 MKI67 PTEN

MGI Mouse Phenotypes related to Endometrial Adenocarcinoma:

46 (show all 27)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.52 FGF2 FGFR2 KRAS KRT7 MLH1 PGR
2 homeostasis/metabolism MP:0005376 10.5 MLH1 PGR PTEN THEMIS2 TP53 VEGFA
3 behavior/neurological MP:0005386 10.44 AKT1 CDKN2A CTSD ERBB2 ESR1 ESR2
4 cardiovascular system MP:0005385 10.44 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
5 endocrine/exocrine gland MP:0005379 10.44 AKT1 CDKN2A CTSD EGFR ERBB2 ESR1
6 growth/size/body region MP:0005378 10.4 AKT1 CDKN2A CTSD EGFR ERBB2 ESR1
7 digestive/alimentary MP:0005381 10.39 CDKN2A CTSD EGFR ERBB2 ESR1 ESR2
8 hematopoietic system MP:0005397 10.39 AKT1 CDKN2A CTSD EGFR ESR1 ESR2
9 integument MP:0010771 10.39 CDKN2A CTSD EGFR ERBB2 ESR1 ESR2
10 mortality/aging MP:0010768 10.39 AKT1 CDKN2A CTSD EGFR ERBB2 ESR1
11 immune system MP:0005387 10.37 AKT1 CDKN2A CTSD EGFR ESR1 ESR2
12 embryo MP:0005380 10.35 AKT1 CDKN2A EGFR ERBB2 ESR1 FGFR2
13 neoplasm MP:0002006 10.32 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
14 muscle MP:0005369 10.31 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
15 nervous system MP:0003631 10.27 AKT1 CDKN2A CTSD EGFR ERBB2 ESR1
16 limbs/digits/tail MP:0005371 10.24 EGFR ERBB2 ESR1 ESR2 FGFR2 KRAS
17 liver/biliary system MP:0005370 10.22 ESR1 ESR2 FGFR2 KRAS PTEN TP53
18 adipose tissue MP:0005375 10.18 AKT1 EGFR ESR1 ESR2 FGFR2 PTEN
19 normal MP:0002873 10.18 AKT1 EGFR ERBB2 ESR1 ESR2 FGFR2
20 hearing/vestibular/ear MP:0005377 10.13 CTSD EGFR ESR2 FGF2 FGFR2 KRAS
21 no phenotypic analysis MP:0003012 10.13 CDKN2A EGFR ESR1 ESR2 FGFR2 KRAS
22 reproductive system MP:0005389 10.1 ERBB2 ESR1 ESR2 FGF2 FGFR2 KRAS
23 renal/urinary system MP:0005367 9.97 EGFR ESR1 ESR2 FGFR2 KRAS KRT7
24 respiratory system MP:0005388 9.93 ERBB2 ESR1 ESR2 FGFR2 KRAS MLH1
25 pigmentation MP:0001186 9.85 TP53 CDKN2A EGFR FGFR2 KRAS PTEN
26 skeleton MP:0005390 9.77 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
27 vision/eye MP:0005391 9.32 MLH1 PTEN TP53 VEGFA CDKN2A CTSD
Sources

Drugs & Therapeutics for Endometrial Adenocarcinoma

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Drugs for Endometrial Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4 Adrenergic Agents Phase 4
5 Adrenergic Agonists Phase 4
6 Adrenergic alpha-2 Receptor Agonists Phase 4
7 Adrenergic alpha-Agonists Phase 4
8 Analgesics Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Anesthetics Phase 4
11 Anesthetics, Dissociative Phase 4
12 Anesthetics, General Phase 4
13 Anesthetics, Intravenous Phase 4
14 Anesthetics, Local Phase 4
15 Central Nervous System Depressants Phase 4
16 Excitatory Amino Acid Antagonists Phase 4
17 Excitatory Amino Acids Phase 4
18 Hypnotics and Sedatives Phase 4
19 Neurotransmitter Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
22
Carboplatin Approved Phase 2, Phase 3,Phase 1 41575-94-4 10339178 498142 38904
23
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
24
Doxorubicin Approved, Investigational Phase 3,Phase 1 23214-92-8 31703
25
Lenograstim Approved, Investigational Phase 3 135968-09-1
26
Epirubicin Approved Phase 3 56420-45-2 41867
27
Metformin Approved Phase 2, Phase 3,Early Phase 1,Not Applicable 657-24-9 14219 4091
28
Doxil Approved June 1999 Phase 3,Phase 1 31703
29 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
30 Antimitotic Agents Phase 3,Phase 2,Phase 1
31 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
32 Hormones Phase 3,Phase 2,Phase 1
33 Adjuvants, Immunologic Phase 3
34 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
35 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
36 Topoisomerase Inhibitors Phase 3,Phase 1
37 Hypoglycemic Agents Phase 2, Phase 3,Early Phase 1,Not Applicable
38 Estrogens Phase 3,Phase 2,Phase 1
39 Hormone Antagonists Phase 3,Phase 2,Phase 1
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
41 Estrogens, Conjugated (USP) Phase 3
42
Levonorgestrel Approved, Investigational Phase 2,Not Applicable 797-63-7, 17489-40-6 13109
43
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
44
Megestrol acetate Approved, Investigational, Vet_approved Phase 2 595-33-5 11683
45
Docetaxel Approved, Investigational Phase 2,Phase 1 114977-28-5 148124
46
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
47
Gemcitabine Approved Phase 2,Phase 1 95058-81-4 60750
48
Everolimus Approved Phase 2,Phase 1 159351-69-6 6442177
49
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
50
Sirolimus Approved, Investigational Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353

Interventional clinical trials:

(show top 50) (show all 74)
# Name Status NCT ID Phase Drugs
1 Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines Active, not recruiting NCT03164590 Phase 4 Ketamine;dexmedetomidine;bupivacaine
2 Laparoscopic Surgery or Standard Surgery in Treating Patients With Endometrial Cancer or Cancer of the Uterus Completed NCT00002706 Phase 3
3 Comparison of Two Combination Chemotherapy Regimens Plus Radiation Therapy in Treating Patients With Stage III or Stage IV Endometrial Cancer Completed NCT00006011 Phase 3 Doxorubicin Hydrochloride;Cisplatin;Paclitaxel
4 Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Endometrial Cancer Completed NCT00005583 Phase 3 cisplatin;doxorubicin hydrochloride;epirubicin hydrochloride
5 Radiation Therapy or Observation Only in Treating Patients With Endometrial Cancer Who Have Undergone Surgery Completed NCT00002807 Phase 3
6 Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Advanced Endometrial Cancer Completed NCT00002493 Phase 3 cisplatin;doxorubicin hydrochloride
7 Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer Completed NCT00006027 Phase 3 cisplatin;paclitaxel
8 Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer Active, not recruiting NCT02065687 Phase 2, Phase 3 Carboplatin;Metformin Hydrochloride;Paclitaxel
9 Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer Active, not recruiting NCT01672892 Phase 3
10 Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer Terminated NCT00002976 Phase 3 conjugated estrogens
11 Treatment With Medroxyprogesterone Acetate Plus LNG-IUS in Young Women With Early Stage Endometrial Cancer Unknown status NCT01594879 Phase 2
12 Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Endometrial Cancer Unknown status NCT01041027 Phase 2 Paclitaxel;Carboplatin
13 Megestrol Acetate Plus Metformin to Megestrol Acetate in Patients With Endometrial Atypical Hyperplasia or Early Stage Endometrial Adenocarcinoma Completed NCT01968317 Phase 2 Megestrol acetate and metformin;Megestrol acetate
14 A Randomized Pilot Study to Evaluate the Effects of a Short Course of Metformin Versus No Therapy in the Period Prior to Hysterectomy for Grade 1-2 Adenocarcinoma of the Endometrium in Obese Non-Diabetic Women Completed NCT01877564 Phase 2 Metformin
15 A Phase II Evaluation of Docetaxel and Carboplatin Followed by Tumor Volume Directed Pelvic Irradiation Completed NCT00285415 Phase 2 Docetaxel and Carboplatin
16 S9720 Combination Chemotherapy in Treating Patients With Metastatic, Recurrent, or Refractory Endometrial Cancer Completed NCT00003127 Phase 2 amifostine trihydrate;carboplatin;paclitaxel
17 Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus Completed NCT00064025 Phase 2 Medroxyprogesterone
18 Ixabepilone in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00095979 Phase 2 ixabepilone
19 Selumetinib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01011933 Phase 2 Selumetinib
20 Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00820898 Phase 2 Gemcitabine Hydrochloride
21 Everolimus in Treating Patients With Relapsed or Metastatic Endometrial Cancer Completed NCT00870337 Phase 2 everolimus
22 Trastuzumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer Completed NCT00006089 Phase 2
23 Akt Inhibitor MK2206 in Treating Patients With Recurrent or Advanced Endometrial Cancer Completed NCT01307631 Phase 2 Akt Inhibitor MK2206
24 Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01132820 Phase 2 Cediranib Maleate
25 Pemetrexed Disodium in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed NCT00087100 Phase 2 pemetrexed disodium
26 Letrozole in Treating Women With Recurrent or Metastatic Endometrial Cancer Completed NCT00004251 Phase 2 letrozole
27 Erlotinib in Treating Patients With Locally Advanced and/or Metastatic Endometrial Cancer Completed NCT00030485 Phase 2 erlotinib hydrochloride
28 Thalidomide in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00025467 Phase 2 thalidomide
29 Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01642082 Phase 2
30 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2 Nintedanib
31 Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed NCT01210222 Phase 2
32 Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer Completed NCT01005329 Phase 2 Carboplatin;Cisplatin;Paclitaxel
33 Brivanib Alaninate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00888173 Phase 2 Brivanib Alaninate
34 Temsirolimus in Treating Patients With Metastatic or Locally Advanced Recurrent Endometrial Cancer Completed NCT00072176 Phase 2 temsirolimus
35 Ridaforolimus in Treating Patients With Recurrent Metastatic and/or Locally Advanced Endometrial Cancer Completed NCT00770185 Phase 2 ridaforolimus
36 Intensity-Modulated Radiation Therapy to the Pelvis With or Without Chemotherapy in Treating Patients With Endometrial Cancer or Cervical Cancer That Has Been Removed By Surgery Completed NCT00331760 Phase 2 cisplatin
37 Evaluation of Oncoxin-Viusid® in Cervical Cancer and Endometrial Adenocarcinoma. Recruiting NCT03540407 Phase 2
38 Pembro/Carbo/Taxol in Endometrial Cancer Recruiting NCT02549209 Phase 2 Pembrolizumab;Paclitaxel;Carboplatin
39 Hormone Receptor Positive endometrIal Carcinoma Treated by Dual mTORC1/mTORC2 Inhibitor and Anastrozole (VICTORIA) Recruiting NCT02730923 Phase 1, Phase 2 AZD2014;Anastrozole
40 Trial of Letrozole + Palbociclib/Placebo in Metastatic Endometrial Cancer Recruiting NCT02730429 Phase 2 Palbociclib/placebo;Letrozole
41 Improving the Treatment for Women With Early Stage Cancer of the Uterus Recruiting NCT01686126 Phase 2 Levonorgestrel;Metformin
42 Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial Cancer Recruiting NCT00492778 Phase 2 Cisplatin
43 An Open-Label, Dose-Escalation, Safety Study of INCAGN01876 in Subjects With Advanced or Metastatic Solid Tumors Recruiting NCT02697591 Phase 1, Phase 2 INCAGN01876
44 Prospective Randomised Phase II Trial Evaluating Adjuvant Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning for Endometrial Cancer. ICORG 09-06 Recruiting NCT01164150 Phase 2
45 A Phase 1/2, Open-Label, Dose-Escalation, Safety Study of INCAGN01949 in Subjects With Advanced or Metastatic Solid Tumors Recruiting NCT02923349 Phase 1, Phase 2 INCAGN01949
46 The Effect of Neoadjuvant DMPA on Glandular Cellularity in Women Awaiting Hysterectomy Active, not recruiting NCT02335203 Phase 2 Depot medroxyprogesterone acetate
47 Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer Active, not recruiting NCT00977574 Phase 2 Carboplatin;Ixabepilone;Paclitaxel;Temsirolimus
48 Sunitinib Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer Active, not recruiting NCT00478426 Phase 2 Sunitinib Malate
49 A Phase Ib Study of the Oral PARP Inhibitor Olaparib With the Oral mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial, Triple Negative Breast, and Ovarian, Primary Peritoneal, or Fallopian Tube Cancer Active, not recruiting NCT02208375 Phase 1, Phase 2 Olaparib;AZD2014;AZD5363
50 Mirena® ± Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer Enrolling by invitation NCT02990728 Phase 2 Metformin

Search NIH Clinical Center for Endometrial Adenocarcinoma

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Genetic Tests for Endometrial Adenocarcinoma

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Anatomical Context for Endometrial Adenocarcinoma

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MalaCards organs/tissues related to Endometrial Adenocarcinoma:

41
Uterus, Lymph Node, Endothelial, Breast, Liver, Cervix, Ovary
Sources

Publications for Endometrial Adenocarcinoma

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Articles related to Endometrial Adenocarcinoma:

(show top 50) (show all 723)
# Title Authors Year
1
Patterns of Recurrence, Long-term Survival and Toxicity Analysis of Endometrial Adenocarcinoma Patients Reclassified Under the Recent ESMO-ESGO-ESTRO Stratification: Seven-Year Results From a Single Institution. ( 29683879 )
2018
2
Endometrial Adenocarcinoma With Pulmonary Recurrence. ( 29326341 )
2018
3
Endometrial Adenocarcinoma, Endometrioid Type. ( 29976383 )
2018
4
Synchronous endometrial adenocarcinoma and carcinosarcoma in endometrial polyp. ( 29854405 )
2018
5
LRIG2 is a growth suppressor of Hec-1A and Ishikawa endometrial adenocarcinoma cells by regulating PI3K/AKT- and EGFR-mediated apoptosis and cell-cycle. ( 29358688 )
2018
6
Overexpression of HOMER2 predicts better outcome in low-grade endometrioid endometrial adenocarcinoma. ( 29891190 )
2018
7
Amide Proton Transfer MR Imaging of Endometrioid Endometrial Adenocarcinoma: Association with Histologic Grade. ( 29083987 )
2018
8
Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature. ( 29295713 )
2018
9
Fertility-Preserving Treatment in Young Women With Grade 1 Presumed Stage IA Endometrial Adenocarcinoma: A Meta-Analysis. ( 29266019 )
2018
10
Disparate genomic characteristics of concurrent endometrial adenocarcinoma and ovarian granulosa cell tumor, revealed by targeted next-generation sequencing. ( 29937308 )
2018
11
Expression of neurotensin receptor 1 in endometrial adenocarcinoma is correlated with histological grade and clinical outcome. ( 28836043 )
2017
12
Ichthyosis Uteri Associated with Endometrial Adenocarcinoma: A Case Report. ( 28764184 )
2017
13
Gastric-Type Endometrial Adenocarcinoma: Report of Two Cases in Patients From the United States. ( 29281925 )
2017
14
Endometrial adenocarcinoma recurrence presenting with tibial metastasis: Report of a case. ( 28500904 )
2017
15
Image-guided high-dose-rate intracavitary brachytherapy in the treatment of medically inoperable early-stage endometrioid type endometrial adenocarcinoma. ( 28958736 )
2017
16
Dual progestin therapy for fertility-sparing treatment of grade 2 endometrial adenocarcinoma. ( 28831417 )
2017
17
Sporadic endometrial adenocarcinoma with MMR deficiency due to biallelic MSH2 somatic mutations. ( 28819700 )
2017
18
Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma. ( 29243125 )
2017
19
Clinical Targeted Next-Generation Sequencing Shows Increased Mutational Load in Endometrioid-type Endometrial Adenocarcinoma With Deficient DNA Mismatch Repair. ( 29084048 )
2017
20
Sentinel lymph node mapping reduces practice pattern variations in surgical staging for endometrial adenocarcinoma: A before and after study. ( 28363672 )
2017
21
MiR-106a promotes tumor growth, migration, and invasion by targeting<i>BCL2L11</i>in human endometrial adenocarcinoma. ( 29218096 )
2017
22
Endometrial adenocarcinoma with choriocarcinomatous differentiation in the uterus of a goat. ( 28529267 )
2017
23
Deep Infiltrating Endometriosis and Endometrial Adenocarcinoma Express High Levels of Myostatin and Its Receptors Messenger RNAs. ( 28345488 )
2017
24
Robotic Splenectomy for Isolated Splenic Recurrence of Endometrial Adenocarcinoma. ( 29128439 )
2017
25
Endometrioid endometrial adenocarcinoma: an increase of G3 cancers? ( 28421274 )
2017
26
Hypermethylation of WIF1 and its inhibitory role in the tumor growth of endometrial adenocarcinoma. ( 28944908 )
2017
27
Corrigendum to &amp;quot;Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells&amp;quot; [J Nutr Biochem 44 (2017) 60-70]. ( 29078859 )
2017
28
Difference in Diffusion-Weighted Magnetic Resonance Imaging and Diffusion Tensor Imaging Parameters Between Endometrioid Endometrial Adenocarcinoma and Uterine Serous Adenocarcinoma: A Retrospective Study. ( 28945213 )
2017
29
Impact of laparoscopy on the biological behavior and gene expression of endometrial adenocarcinoma cells. ( 28656791 )
2017
30
Pap Smears in Endometrial Adenocarcinoma: Does It Have a Role? ( 28547956 )
2017
31
The importance of hCG in human endometrial adenocarcinoma and breast cancer. ( 28967068 )
2017
32
Radiation-induced circumscribed superficial morphea after brachytherapy for endometrial adenocarcinoma. ( 29234720 )
2017
33
Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma. ( 28890428 )
2017
34
miR-202 Suppresses Cell Proliferation by Targeting FOXR2 in Endometrial Adenocarcinoma. ( 28827892 )
2017
35
Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma. ( 28718377 )
2017
36
Acetylenic derivative of betulin induces apoptosis in endometrial adenocarcinoma cell line. ( 28863383 )
2017
37
Malignant changes in adenomyosis in patients with endometrial adenocarcinoma: A case series. ( 29069006 )
2017
38
BAG3 Protein Is Over-Expressed in Endometrioid Endometrial Adenocarcinomas. ( 27414463 )
2017
39
Curcumin exhibits anti-tumor effect and attenuates cellular migration via Slit-2 mediated down-regulation of SDF-1 and CXCR4 in endometrial adenocarcinoma cells. ( 28402926 )
2017
40
Identification of key genes in endometrioid endometrial adenocarcinoma via TCGA database. ( 29060924 )
2017
41
Overexpression of erythropoietin-producing hepatocyte receptor B4 and ephrin-B2 is associated with estrogen receptor expression in endometrial adenocarcinoma. ( 28454369 )
2017
42
Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma. ( 28929002 )
2017
43
The Anticancer Effects of Radachlorin-mediated Photodynamic Therapy in the Human Endometrial Adenocarcinoma Cell Line HEC-1-A. ( 29061808 )
2017
44
Giant Cavernous Hepatic Hemangioma Diagnosed Incidentally in a Perimenopausal Obese Female with Endometrial Adenocarcinoma: A Case Report. ( 26851037 )
2016
45
Could S6K1 immunopositivity be used to distinguish early and advanced stages of endometrioid endometrial adenocarcinoma? ( 27651726 )
2016
46
Stage I and II Endometrial Adenocarcinoma: Analysis of 2009 FIGO Staging Revision and Impact on Survival by Adjuvant Therapy. ( 26886945 )
2016
47
Endometrial adenocarcinoma in a 13-year-old girl. ( 27004208 )
2016
48
Aberrant expression of hSef and Sprouty4 in endometrial adenocarcinoma. ( 26870165 )
2016
49
Growth Hormone differentially modulates chemoresistance in human endometrial adenocarcinoma cell lines. ( 27585662 )
2016
50
Differential Diagnosis between Primary Endocervical and Endometrial Adenocarcinoma using Immunohistochemical Staining of Estrogen Receptor, Vimentin, Carcinoembryonic Antigen and p16. ( 27266224 )
2016
Sources

Variations for Endometrial Adenocarcinoma

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ClinVar genetic disease variations for Endometrial Adenocarcinoma:

6
(show all 36)
# Gene Variation Type Significance SNP ID Assembly Location
1 FGFR2 NM_022970.3(FGFR2): c.755C> G (p.Ser252Trp) single nucleotide variant Pathogenic rs79184941 GRCh37 Chromosome 10, 123279677: 123279677
2 FGFR2 NM_022970.3(FGFR2): c.755C> G (p.Ser252Trp) single nucleotide variant Pathogenic rs79184941 GRCh38 Chromosome 10, 121520163: 121520163
3 AKT1 NM_005163.2(AKT1): c.49G> A (p.Glu17Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121434592 GRCh37 Chromosome 14, 105246551: 105246551
4 AKT1 NM_005163.2(AKT1): c.49G> A (p.Glu17Lys) single nucleotide variant Pathogenic/Likely pathogenic rs121434592 GRCh38 Chromosome 14, 104780214: 104780214
5 FGFR2 NM_000141.4(FGFR2): c.1694A> G (p.Glu565Gly) single nucleotide variant Likely pathogenic rs121918506 GRCh37 Chromosome 10, 123256215: 123256215
6 FGFR2 NM_000141.4(FGFR2): c.1694A> G (p.Glu565Gly) single nucleotide variant Likely pathogenic rs121918506 GRCh38 Chromosome 10, 121496701: 121496701
7 FGFR2 NM_000141.4(FGFR2): c.1645A> C (p.Asn549His) single nucleotide variant Likely pathogenic rs1057519045 GRCh37 Chromosome 10, 123258036: 123258036
8 FGFR2 NM_000141.4(FGFR2): c.1645A> C (p.Asn549His) single nucleotide variant Likely pathogenic rs1057519045 GRCh38 Chromosome 10, 121498522: 121498522
9 EGFR NM_005228.4(EGFR): c.2068G> A (p.Glu690Lys) single nucleotide variant Likely pathogenic rs1057519794 GRCh37 Chromosome 7, 55241620: 55241620
10 EGFR NM_005228.4(EGFR): c.2068G> A (p.Glu690Lys) single nucleotide variant Likely pathogenic rs1057519794 GRCh38 Chromosome 7, 55173927: 55173927
11 FGFR2 NM_022970.3(FGFR2): c.1978A> G (p.Lys660Glu) single nucleotide variant Likely pathogenic rs1057519795 GRCh37 Chromosome 10, 123247516: 123247516
12 FGFR2 NM_022970.3(FGFR2): c.1978A> G (p.Lys660Glu) single nucleotide variant Likely pathogenic rs1057519795 GRCh38 Chromosome 10, 121488002: 121488002
13 FGFR2 NM_000141.4(FGFR2): c.1849T> A (p.Leu617Met) single nucleotide variant Likely pathogenic rs1057519796 GRCh37 Chromosome 10, 123256060: 123256060
14 FGFR2 NM_000141.4(FGFR2): c.1849T> A (p.Leu617Met) single nucleotide variant Likely pathogenic rs1057519796 GRCh38 Chromosome 10, 121496546: 121496546
15 FGFR2 NM_000141.4(FGFR2): c.1690G> A (p.Val564Ile) single nucleotide variant Likely pathogenic rs1057519797 GRCh37 Chromosome 10, 123256219: 123256219
16 FGFR2 NM_000141.4(FGFR2): c.1690G> A (p.Val564Ile) single nucleotide variant Likely pathogenic rs1057519797 GRCh38 Chromosome 10, 121496705: 121496705
17 FGFR2 NM_022970.3(FGFR2): c.1650T> G (p.Asn550Lys) single nucleotide variant Likely pathogenic rs121913476 GRCh37 Chromosome 10, 123258034: 123258034
18 FGFR2 NM_022970.3(FGFR2): c.1650T> G (p.Asn550Lys) single nucleotide variant Likely pathogenic rs121913476 GRCh38 Chromosome 10, 121498520: 121498520
19 FGFR2 NM_000141.4(FGFR2): c.1647T> A (p.Asn549Lys) single nucleotide variant Likely pathogenic rs121913476 GRCh37 Chromosome 10, 123258034: 123258034
20 FGFR2 NM_000141.4(FGFR2): c.1647T> A (p.Asn549Lys) single nucleotide variant Likely pathogenic rs121913476 GRCh38 Chromosome 10, 121498520: 121498520
21 FGFR2 NM_000141.4(FGFR2): c.1639A> G (p.Ile547Val) single nucleotide variant Likely pathogenic rs1057519798 GRCh37 Chromosome 10, 123258042: 123258042
22 FGFR2 NM_000141.4(FGFR2): c.1639A> G (p.Ile547Val) single nucleotide variant Likely pathogenic rs1057519798 GRCh38 Chromosome 10, 121498528: 121498528
23 FGFR2 NM_022970.3(FGFR2): c.1614G> T (p.Met538Ile) single nucleotide variant Likely pathogenic rs1057519799 GRCh37 Chromosome 10, 123258070: 123258070
24 FGFR2 NM_022970.3(FGFR2): c.1614G> T (p.Met538Ile) single nucleotide variant Likely pathogenic rs1057519799 GRCh38 Chromosome 10, 121498556: 121498556
25 FGFR2 NM_022970.3(FGFR2): c.1614G> C (p.Met538Ile) single nucleotide variant Likely pathogenic rs1057519799 GRCh37 Chromosome 10, 123258070: 123258070
26 FGFR2 NM_022970.3(FGFR2): c.1614G> C (p.Met538Ile) single nucleotide variant Likely pathogenic rs1057519799 GRCh38 Chromosome 10, 121498556: 121498556
27 FGFR2 NM_000141.4(FGFR2): c.1611G> A (p.Met537Ile) single nucleotide variant Likely pathogenic rs1057519799 GRCh38 Chromosome 10, 121498556: 121498556
28 FGFR2 NM_000141.4(FGFR2): c.1611G> A (p.Met537Ile) single nucleotide variant Likely pathogenic rs1057519799 GRCh37 Chromosome 10, 123258070: 123258070
29 FGFR2 NM_000141.4(FGFR2): c.1605G> T (p.Met535Ile) single nucleotide variant Likely pathogenic rs1057519800 GRCh37 Chromosome 10, 123258076: 123258076
30 FGFR2 NM_000141.4(FGFR2): c.1605G> T (p.Met535Ile) single nucleotide variant Likely pathogenic rs1057519800 GRCh38 Chromosome 10, 121498562: 121498562
31 FGFR2 NM_022970.3(FGFR2): c.1608G> C (p.Met536Ile) single nucleotide variant Likely pathogenic rs1057519800 GRCh37 Chromosome 10, 123258076: 123258076
32 FGFR2 NM_022970.3(FGFR2): c.1608G> C (p.Met536Ile) single nucleotide variant Likely pathogenic rs1057519800 GRCh38 Chromosome 10, 121498562: 121498562
33 FGFR2 NM_022970.3(FGFR2): c.1608G> A (p.Met536Ile) single nucleotide variant Likely pathogenic rs1057519800 GRCh37 Chromosome 10, 123258076: 123258076
34 FGFR2 NM_022970.3(FGFR2): c.1608G> A (p.Met536Ile) single nucleotide variant Likely pathogenic rs1057519800 GRCh38 Chromosome 10, 121498562: 121498562
35 PIK3R2 NM_005027.3(PIK3R2): c.1681A> G (p.Asn561Asp) single nucleotide variant Likely pathogenic rs1057519801 GRCh37 Chromosome 19, 18278061: 18278061
36 PIK3R2 NM_005027.3(PIK3R2): c.1681A> G (p.Asn561Asp) single nucleotide variant Likely pathogenic rs1057519801 GRCh38 Chromosome 19, 18167251: 18167251

Cosmic variations for Endometrial Adenocarcinoma:

9
(show top 50) (show all 4113)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6904337 TSC1 endometrium,NS,carcinoma,adenocarcinoma c.2698C>G p.Q900E 9:132897538-132897538 15
2 COSM10709 TP53 endometrium,NS,carcinoma,adenocarcinoma c.722C>G p.S241C 17:7674241-7674241 15
3 COSM44063 TP53 endometrium,NS,carcinoma,adenocarcinoma c.389T>G p.L130R 17:7675223-7675223 15
4 COSM11073 TP53 endometrium,NS,carcinoma,adenocarcinoma c.1024C>T p.R342* 17:7670685-7670685 15
5 COSM44622 TP53 endometrium,NS,carcinoma,adenocarcinoma c.694A>G p.I232V 17:7674269-7674269 15
6 COSM10654 TP53 endometrium,NS,carcinoma,adenocarcinoma c.637C>T p.R213* 17:7674894-7674894 15
7 COSM45035 TP53 endometrium,NS,carcinoma,adenocarcinoma c.761T>G p.I254S 17:7674202-7674202 15
8 COSM43545 TP53 endometrium,NS,carcinoma,adenocarcinoma c.503A>G p.H168R 17:7675109-7675109 15
9 COSM43596 TP53 endometrium,NS,carcinoma,adenocarcinoma c.841G>A p.D281N 17:7673779-7673779 15
10 COSM5154 PTEN endometrium,NS,carcinoma,adenocarcinoma c.697C>T p.R233* 10:87957915-87957915 15
11 COSM5312 PTEN endometrium,NS,carcinoma,adenocarcinoma c.895G>T p.E299* 10:87960987-87960987 15
12 COSM5106 PTEN endometrium,NS,carcinoma,adenocarcinoma c.335T>C p.L112P 10:87933094-87933094 15
13 COSM5039 PTEN endometrium,NS,carcinoma,adenocarcinoma c.518G>A p.R173H 10:87952143-87952143 15
14 COSM5115 PTEN endometrium,NS,carcinoma,adenocarcinoma c.155A>G p.D52G 10:87894100-87894100 15
15 COSM5943 PTEN endometrium,NS,carcinoma,adenocarcinoma c.634+3A>C p.? 10:87952262-87952262 15
16 COSM5276 PTEN endometrium,NS,carcinoma,adenocarcinoma c.386G>T p.G129V 10:87933145-87933145 15
17 COSM5108 PTEN endometrium,NS,carcinoma,adenocarcinoma c.209T>C p.L70P 10:87925557-87925557 15
18 COSM5165 PTEN endometrium,NS,carcinoma,adenocarcinoma c.519C>T p.R173R 10:87952144-87952144 15
19 COSM5215 PTEN endometrium,NS,carcinoma,adenocarcinoma c.356T>A p.V119D 10:87933115-87933115 15
20 COSM5235 PTEN endometrium,NS,carcinoma,adenocarcinoma c.218A>T p.E73V 10:87931054-87931054 15
21 COSM5299 PTEN endometrium,NS,carcinoma,adenocarcinoma c.271G>T p.E91* 10:87933030-87933030 15
22 COSM5048 PTEN endometrium,NS,carcinoma,adenocarcinoma c.196A>G p.K66E 10:87925544-87925544 15
23 COSM937331 POLE endometrium,NS,carcinoma,adenocarcinoma c.890C>T p.S297F 12:132676565-132676565 15
24 COSM5031089 POLE endometrium,NS,carcinoma,adenocarcinoma c.890C>A p.S297Y 12:132676565-132676565 15
25 COSM760 PIK3CA endometrium,NS,carcinoma,adenocarcinoma c.1624G>A p.E542K 3:179218294-179218294 15
26 COSM2726759 PHF6 endometrium,NS,carcinoma,adenocarcinoma c.635G>A p.C212Y 23:134413872-134413872 15
27 COSM13396 MSH6 endometrium,NS,carcinoma,adenocarcinoma c.1723G>T p.D575Y 2:47799706-47799706 15
28 COSM6904333 MSH6 endometrium,NS,carcinoma,adenocarcinoma c.3787C>T p.R1263C 2:47806344-47806344 15
29 COSM532 KRAS endometrium,NS,carcinoma,adenocarcinoma c.38G>A p.G13D 12:25245347-25245347 15
30 COSM516 KRAS endometrium,NS,carcinoma,adenocarcinoma c.34G>T p.G12C 12:25245351-25245351 15
31 COSM535 KRAS endometrium,NS,carcinoma,adenocarcinoma c.39C>G p.G13G 12:25245346-25245346 15
32 COSM1562184 KRAS endometrium,NS,carcinoma,adenocarcinoma c.25G>A p.V9I 12:25245360-25245360 15
33 COSM3735050 KRAS endometrium,NS,carcinoma,adenocarcinoma c.53C>T p.A18V 12:25245332-25245332 15
34 COSM3735049 KRAS endometrium,NS,carcinoma,adenocarcinoma c.45C>T p.G15G 12:25245340-25245340 15
35 COSM22964 FBXW7 endometrium,NS,carcinoma,adenocarcinoma c.1099C>T p.R367* 4:152330755-152330755 15
36 COSM22966 FBXW7 endometrium,NS,carcinoma,adenocarcinoma c.1435C>G p.R479G 4:152326215-152326215 15
37 COSM6856747 FBXW7 endometrium,NS,carcinoma,adenocarcinoma c.1387A>G p.T463A 4:152328239-152328239 15
38 COSM6904330 DDR2 endometrium,NS,carcinoma,adenocarcinoma c.575T>C p.V192A 1:162755673-162755673 15
39 COSM5699 CTNNB1 endometrium,NS,carcinoma,adenocarcinoma c.128C>T p.A43V 3:41224640-41224640 15
40 COSM446029 endometrium,NS,carcinoma,adenocarcinoma c.3145G>C p.G1049R 3:179234302-179234302 15
41 COSM6935601 ZRSR2 endometrium,NS,carcinoma,endometrioid carcinoma c.1124G>T p.S375I 23:15822917-15822917 8
42 COSM6982868 ZRSR2 endometrium,NS,carcinoma,endometrioid carcinoma c.854C>A p.S285Y 23:15820233-15820233 8
43 COSM6935600 ZRSR2 endometrium,NS,carcinoma,endometrioid carcinoma c.514T>A p.C172S 23:15809275-15809275 8
44 COSM6845183 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.2143C>T p.R715* 16:72958003-72958003 8
45 COSM6845177 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.7490C>T p.S2497L 16:72795192-72795192 8
46 COSM6845174 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.4129C>A p.L1377I 16:72798553-72798553 8
47 COSM973503 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.8152G>A p.A2718T 16:72794530-72794530 8
48 COSM6845142 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.3504G>T p.E1168D 16:72829804-72829804 8
49 COSM6845190 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.9555A>C p.Q3185H 16:72788721-72788721 8
50 COSM6845133 ZFHX3 endometrium,NS,carcinoma,endometrioid carcinoma c.2740G>A p.D914N 16:72950945-72950945 8
Sources

Expression for Endometrial Adenocarcinoma

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Search GEO for disease gene expression data for Endometrial Adenocarcinoma.
Sources

Pathways for Endometrial Adenocarcinoma

About this section

Pathways related to Endometrial Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.92 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
2
Gene Expression 66
Show member pathways
 13.88 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
3
GPCR Pathway 64
Show member pathways
 13.79 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
4
TGF-Beta Pathway 64
Show member pathways
 13.59 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
5
Developmental Biology 66
Show member pathways
 13.58 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
6
Class I MHC mediated antigen processing and presentation 66
Show member pathways
 13.53 AKT1 CTSD EGFR ERBB2 FGF2 FGFR2
7
Akt Signaling 64
Show member pathways
 13.5 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
8
Cytokine Signaling in Immune system 66
Show member pathways
 13.44 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
9
CREB Pathway 64
Show member pathways
 13.4 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
10
PAK Pathway 64
Show member pathways
 13.38 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
11
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.35 AKT1 EGFR ERBB2 ESR1 ESR2 FGF2
12
PI3K/AKT activation 66
Show member pathways
 13.2 AKT1 EGFR ERBB2 FGF2 FGFR2 PTEN
13
Phospholipase-C Pathway 64
Show member pathways
 13.14 AKT1 EGFR FGF2 FGFR2 KRAS PTEN
14
Circadian entrainment 37
Show member pathways
 13.1 AKT1 CTSD EGFR ESR1 ESR2 KRAS
15
PI3K-Akt signaling pathway 37
Show member pathways
 13.03 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
16
Regulation of lipid metabolism Insulin signaling-generic cascades 22
Show member pathways
 12.99 AKT1 EGFR ERBB2 KRAS PTEN VEGFA
17
Focal Adhesion 37 1
Show member pathways
 12.98 AKT1 EGFR ERBB2 KRAS PTEN VEGFA
18
NFAT and Cardiac Hypertrophy 64
Show member pathways
 12.95 AKT1 EGFR ERBB2 FGFR2 KRAS PTEN
19
Apoptosis Modulation and Signaling 1
Show member pathways
 12.88 AKT1 CDKN2A CTSD KRAS TP53
20
ErbB4 Pathway 64
Show member pathways
 12.86 AKT1 EGFR ERBB2 KRAS PTEN
21
MAPK signaling pathway 1 37
12.83 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
22
Ras signaling pathway 37
Show member pathways
 12.81 AKT1 EGFR FGF2 FGFR2 KRAS VEGFA
23
Endometrial cancer 37
Show member pathways
 12.81 AKT1 CDKN2A EGFR ERBB2 FGFR2 KRAS
24
Development HGF signaling pathway 22
Show member pathways
 12.8 AKT1 ERBB2 ESR1 KRAS PTEN TP53
25
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.78 AKT1 EGFR ERBB2 FGF2 FGFR2 KRAS
26
Development Endothelin-1/EDNRA signaling 22
Show member pathways
 12.75 AKT1 EGFR KRAS PTEN VEGFA
27
Immune response IL-23 signaling pathway 22
Show member pathways
 12.68 AKT1 EGFR ERBB2 FGF2 KRAS TP53
28
Kaposi's sarcoma-associated herpesvirus infection 37
Show member pathways
 12.66 AKT1 FGF2 KRAS PTEN TP53 VEGFA
29
Development EGFR signaling pathway 22
Show member pathways
 12.63 AKT1 EGFR ERBB2 KRAS TP53
30
MicroRNAs in cancer 37
12.6 CDKN2A EGFR ERBB2 KRAS PTEN TP53
31
Glioma 37
Show member pathways
 12.6 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
32
mTOR signaling pathway (KEGG) 65
Show member pathways
 12.58 AKT1 EGFR ERBB2 FGFR2 KRAS PTEN
33
ErbB signaling pathway 1 37
Show member pathways
 12.57 AKT1 EGFR ERBB2 KRAS TP53 VEGFA
34
Prolactin Signaling Pathway 1 37
Show member pathways
 12.56 AKT1 CTSD ERBB2 ESR1 ESR2 KRAS
35
Apoptosis Pathway 72
Show member pathways
 12.53 AKT1 EGFR ERBB2 FGFR2 KRAS TP53
36
HTLV-I infection 37
12.49 AKT1 CDKN2A KRAS TP53
37
RhoGDI Pathway 64
Show member pathways
 12.46 EGFR FGF2 FGFR2 VEGFA
38
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.46 AKT1 ESR1 KRAS VEGFA
39
Gastric cancer 37
Show member pathways
 12.44 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2
40
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.41 AKT1 EGFR ERBB2 ESR1 ESR2
41
Signaling by ERBB2 66
Show member pathways
 12.39 AKT1 EGFR ERBB2 KRAS
42
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.31 AKT1 KRAS TP53 VEGFA
43
Colorectal Cancer Metastasis 64
12.29 AKT1 EGFR KRAS MLH1 TP53 VEGFA
44
EGF/EGFR Signaling Pathway 1
12.28 AKT1 EGFR ERBB2 KRAS PTEN
45
Cellular senescence (KEGG) 37
12.26 AKT1 CDKN2A KRAS PTEN TP53
46
VEGF Signaling Pathway 67 61
Show member pathways
 12.25 AKT1 EGFR FGF2 FGFR2 KRAS PTEN
47
Development EGFR signaling via small GTPases 22
Show member pathways
 12.23 AKT1 EGFR ERBB2 KRAS PTEN
48
Proteoglycans in cancer 37
12.23 AKT1 EGFR ERBB2 ESR1 FGF2 KRAS
49
Tyrosine Kinases / Adaptors 4
12.22 EGFR ERBB2 FGF2 FGFR2
50
Transcription Androgen Receptor nuclear signaling 22
Show member pathways
 12.21 AKT1 EGFR ERBB2 PTEN
Sources

GO Terms for Endometrial Adenocarcinoma

About this section

Cellular components related to Endometrial Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 AKT1 CDKN2A EGFR ERBB2 ESR1 ESR2

Biological processes related to Endometrial Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.99 AKT1 ESR1 PGR VEGFA
2 cell proliferation GO:0008283 9.99 AKT1 EGFR ERBB2 MKI67 PTEN TP53
3 MAPK cascade GO:0000165 9.97 EGFR ERBB2 FGF2 FGFR2 KRAS
4 protein autophosphorylation GO:0046777 9.95 AKT1 EGFR ERBB2 FGFR2
5 peptidyl-tyrosine phosphorylation GO:0018108 9.95 EGFR ERBB2 FGF2 FGFR2
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 EGFR ERBB2 FGF2 FGFR2 PTEN
7 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 AKT1 CDKN2A EGFR ESR1 FGF2 FGFR2
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 AKT1 EGFR VEGFA
9 positive regulation of cell growth GO:0030307 9.88 AKT1 EGFR ERBB2
10 cellular response to hypoxia GO:0071456 9.88 AKT1 PTEN TP53 VEGFA
11 regulation of protein stability GO:0031647 9.87 CDKN2A KRAS PTEN
12 positive regulation of cell proliferation GO:0008284 9.87 AKT1 EGFR FGF2 FGFR2 KRAS PTEN
13 positive regulation of kinase activity GO:0033674 9.86 EGFR ERBB2 FGFR2
14 positive regulation of endothelial cell proliferation GO:0001938 9.86 AKT1 FGF2 VEGFA
15 positive regulation of DNA binding transcription factor activity GO:0051091 9.86 AKT1 ESR1 ESR2 PTEN
16 epidermal growth factor receptor signaling pathway GO:0007173 9.85 AKT1 EGFR KRAS
17 steroid hormone mediated signaling pathway GO:0043401 9.85 ESR1 ESR2 PGR
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.84 AKT1 EGFR FGFR2
19 cellular response to growth factor stimulus GO:0071363 9.83 AKT1 EGFR ERBB2
20 wound healing GO:0042060 9.83 EGFR ERBB2 FGF2 FGFR2
21 positive regulation of blood vessel endothelial cell migration GO:0043536 9.81 AKT1 FGF2 VEGFA
22 positive regulation of cell division GO:0051781 9.8 FGF2 FGFR2 VEGFA
23 cellular response to epidermal growth factor stimulus GO:0071364 9.8 AKT1 EGFR ERBB2
24 Ras protein signal transduction GO:0007265 9.8 CDKN2A FGF2 KRAS TP53
25 positive regulation of protein phosphorylation GO:0001934 9.8 AKT1 EGFR ERBB2 KRAS VEGFA
26 ERBB2 signaling pathway GO:0038128 9.78 EGFR ERBB2 KRAS
27 positive regulation of cardiac muscle cell proliferation GO:0060045 9.77 FGF2 FGFR2 MIR204
28 positive regulation of protein kinase B signaling GO:0051897 9.77 EGFR ERBB2 ESR1 FGF2 FGFR2
29 positive regulation of epithelial cell proliferation GO:0050679 9.73 EGFR ERBB2 FGFR2 VEGFA
30 regulation of ERK1 and ERK2 cascade GO:0070372 9.72 EGFR ERBB2 FGFR2
31 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.71 ESR1 TP53
32 negative regulation of cell size GO:0045792 9.7 AKT1 PTEN
33 positive regulation of phospholipase C activity GO:0010863 9.68 ESR1 FGF2
34 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.68 CDKN2A PTEN
35 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.67 AKT1 EGFR
36 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.67 ESR1 FGFR2
37 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 9.65 ESR1 FGFR2
38 negative regulation of immature T cell proliferation in thymus GO:0033088 9.63 CDKN2A ERBB2
39 cellular response to decreased oxygen levels GO:0036294 9.62 AKT1 PTEN
40 response to UV-A GO:0070141 9.59 AKT1 EGFR
41 prostate epithelial cord elongation GO:0060523 9.58 ESR1 FGFR2
42 phosphatidylinositol phosphorylation GO:0046854 9.55 EGFR ERBB2 ESR1 FGF2 FGFR2
43 positive regulation of gene expression GO:0010628 9.5 AKT1 CDKN2A ERBB2 KRAS PTEN TP53
44 positive regulation of MAP kinase activity GO:0043406 9.02 EGFR ERBB2 FGF2 KRAS VEGFA
45 multicellular organism development GO:0007275 10.24 AKT1 EGFR ERBB2 FGF2 FGFR2 TP53
46 cell differentiation GO:0030154 10.19 AKT1 EGFR ERBB2 FGF2 FGFR2 TP53
47 positive regulation of transcription, DNA-templated GO:0045893 10.02 AKT1 CDKN2A EGFR ESR1 ESR2 FGF2
48 cytokine-mediated signaling pathway GO:0019221 10.01 AKT1 FGF2 KRAS TP53 VEGFA
49 angiogenesis GO:0001525 10 FGF2 FGFR2 PTEN VEGFA
50 negative regulation of apoptotic process GO:0043066 10 AKT1 EGFR ERBB2 FGFR2 PTEN TP53

Molecular functions related to Endometrial Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.96 AKT1 EGFR ERBB2 FGFR2 KRAS
2 identical protein binding GO:0042802 9.91 AKT1 EGFR ERBB2 ESR1 ESR2 PGR
3 protein tyrosine kinase activity GO:0004713 9.84 EGFR ERBB2 FGF2 FGFR2
4 protein kinase binding GO:0019901 9.8 AKT1 CDKN2A EGFR ESR1 PTEN TP53
5 MAP kinase kinase kinase activity GO:0004709 9.77 EGFR ERBB2 FGFR2
6 protein phosphatase binding GO:0019903 9.76 EGFR ERBB2 TP53
7 mitogen-activated protein kinase kinase binding GO:0031434 9.75 EGFR ERBB2 FGFR2
8 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.74 EGFR ERBB2 FGFR2
9 steroid hormone receptor activity GO:0003707 9.72 ESR1 ESR2 PGR
10 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.71 EGFR ERBB2 FGF2 FGFR2
11 nuclear receptor activity GO:0004879 9.67 ESR1 ESR2 PGR
12 core promoter sequence-specific DNA binding GO:0001046 9.65 ESR1 ESR2 TP53
13 steroid binding GO:0005496 9.61 ESR1 ESR2 PGR
14 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.59 EGFR ERBB2
15 estrogen receptor activity GO:0030284 9.51 ESR1 ESR2
16 enzyme binding GO:0019899 9.5 AKT1 EGFR ESR1 ESR2 PGR PTEN
17 estrogen response element binding GO:0034056 9.46 ESR1 ESR2
18 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 9.37 ESR1 ESR2
19 nitric-oxide synthase regulator activity GO:0030235 9.33 AKT1 EGFR ESR1
20 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.02 EGFR ERBB2 ESR1 FGF2 FGFR2
21 protein binding GO:0005515 10.48 AKT1 CDKN2A CTSD EGFR ERBB2 ESR1
Sources

Sources for Endometrial Adenocarcinoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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