MCID: END015
MIFTS: 27

Endometrial Adenosquamous Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Endometrial Adenosquamous Carcinoma

MalaCards integrated aliases for Endometrial Adenosquamous Carcinoma:

Name: Endometrial Adenosquamous Carcinoma 12 20 15 17 70
Adenosquamous Carcinoma of the Endometrium 20
Endometrial Adenosquamous Cell Carcinoma 70
Adenosquamous Carcinoma of Endometrium 12
Endometrial Adenosquamous Cancer 20

Classifications:



External Ids:

Disease Ontology 12 DOID:5631
UMLS 70 C0279670 C3896969

Summaries for Endometrial Adenosquamous Carcinoma

Disease Ontology : 12 An endometrial carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Endometrial Adenosquamous Carcinoma, also known as adenosquamous carcinoma of the endometrium, is related to endometrial cancer and neuroendocrine carcinoma. An important gene associated with Endometrial Adenosquamous Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Regulation of TP53 Activity and DNA Damage Response. The drugs Cisplatin and Paclitaxel have been mentioned in the context of this disorder. Affiliated tissues include cervix.

Related Diseases for Endometrial Adenosquamous Carcinoma

Diseases related to Endometrial Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 endometrial cancer 10.3
2 neuroendocrine carcinoma 10.1
3 endometrial adenocarcinoma 10.1
4 neuroendocrine carcinoma of the cervix 10.1
5 adenosquamous carcinoma 10.0
6 malignant granular cell myoblastoma 10.0 SERPINA3 BRD7
7 rhabdoid cancer 9.9 SERPINA3 BRD7
8 tuberous sclerosis 2 9.6 SESN2 SESN1
9 pulmonary emphysema 9.6 SESN2 SERPINA3

Graphical network of the top 20 diseases related to Endometrial Adenosquamous Carcinoma:



Diseases related to Endometrial Adenosquamous Carcinoma

Symptoms & Phenotypes for Endometrial Adenosquamous Carcinoma

Drugs & Therapeutics for Endometrial Adenosquamous Carcinoma

Drugs for Endometrial Adenosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4 Antimitotic Agents Phase 3
5 Albumin-Bound Paclitaxel Phase 3
6 Tubulin Modulators Phase 3
7
Liposomal doxorubicin Phase 3 31703
8 Antibiotics, Antitubercular Phase 3
9 Anti-Bacterial Agents Phase 3
10
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
11
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
12
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
13 Hormones Phase 2
14 Estrogen Antagonists Phase 2
15 Hormone Antagonists Phase 2
16 Estrogen Receptor Antagonists Phase 2
17 Aromatase Inhibitors Phase 2
18 Estrogens Phase 2
19 Protective Agents Phase 2
20 Radiation-Protective Agents Phase 2
21
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
22 Protein Kinase Inhibitors Phase 2
23
Lenograstim Approved, Investigational Phase 1 135968-09-1
24 insulin
25 Insulin, Globin Zinc

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Phase III Study of Adjuvant Postoperative Irradiation With or Without Cisplatin/Taxol Chemotherapy Following TAH/BSO for Patients With Endometrial Cancer Completed NCT00006027 Phase 3 cisplatin;paclitaxel
2 WHOLE ABDOMINAL RADIOTHERAPY VERSUS CIRCADIAN-TIMED COMBINATION DOXORUBICIN-CISPLATIN CHEMOTHERAPY IN ADVANCED ENDOMETRIAL CARCINOMA -- PHASE III Completed NCT00002493 Phase 3 cisplatin;doxorubicin hydrochloride
3 A Phase II Study of Ridaforolimus in Patients With Metastatic And/Or Locally Advanced Recurrent Endometrial Cancer Completed NCT00770185 Phase 2 ridaforolimus
4 A Phase II Study of Intensity Modulated Radiation Therapy (IMRT) to the Pelvis ± Chemotherapy for Post-Operative Patients With Either Endometrial or Cervical Carcinoma Completed NCT00331760 Phase 2 cisplatin
5 A Phase II Study of Letrozole in Patients With Advanced or Recurrent Endometrial Cancer Completed NCT00004251 Phase 2 letrozole
6 Phase II Trial of Paclitaxel and Carboplatin With Amifostine in Advanced Recurrent or Refractory Endometrial Adenocarcinoma Completed NCT00003127 Phase 2 amifostine trihydrate;carboplatin;paclitaxel
7 A Phase II Study of OSI-774 (NSC 718781) in Patients With Locally Advanced and/or Metastatic Carcinoma of the Endometrium Completed NCT00030485 Phase 2 erlotinib hydrochloride
8 A Phase 2 Study of XL184 (Cabozantinib) in Recurrent or Metastatic Endometrial Cancer Active, not recruiting NCT01935934 Phase 2 Cabozantinib S-malate
9 A Phase I Study of IV Doxorubicin Plus Intraperitoneal (IP) Paclitaxel and IV or IP Cisplatin in Endometrial Cancer Patients at High Risk for Peritoneal Failure Completed NCT00575952 Phase 1 Cisplatin;Doxorubicin Hydrochloride;Paclitaxel
10 Role of Sex Hormone and Insulin/IGF Axes in Endometrial Cancer Recurrence Unknown status NCT01150682
11 A Phase III Randomized Trial Comparing TAH BSO Versus TAH BSO Plus Adjuvant Pelvic Irradiation in Intermediate Risk Carcinoma of the Endometrium Completed NCT00002807

Search NIH Clinical Center for Endometrial Adenosquamous Carcinoma

Genetic Tests for Endometrial Adenosquamous Carcinoma

Anatomical Context for Endometrial Adenosquamous Carcinoma

MalaCards organs/tissues related to Endometrial Adenosquamous Carcinoma:

40
Cervix

Publications for Endometrial Adenosquamous Carcinoma

Articles related to Endometrial Adenosquamous Carcinoma:

# Title Authors PMID Year
1
Endometrial carcinoma recurring as carcinosarcoma: report of two cases. 61
17646054 2007
2
Glassy cell carcinoma of the endometrium: a case report and review of the literature. 61
17400400 2007
3
Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis. 61
15723689 2005
4
Effects of epidermal growth factor on growth response, morphology, and invasive potential of human endometrial carcinoma cell line RL95-2. 61
1904255 1991
5
Flow cytometric analysis and cytopathology of body cavity fluids. 61
3469844 1987
6
Benign senile pyometra, endometrial cholesterol granulomas and adenosquamous carcinoma. 61
3863595 1985
7
Adenosquamous carcinoma of the endometrium. 61
1002838 1976

Variations for Endometrial Adenosquamous Carcinoma

Expression for Endometrial Adenosquamous Carcinoma

Search GEO for disease gene expression data for Endometrial Adenosquamous Carcinoma.

Pathways for Endometrial Adenosquamous Carcinoma

GO Terms for Endometrial Adenosquamous Carcinoma

Cellular components related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.76 ZNF81 SVEP1 SESN3 SESN2 SESN1 SERPINA3
2 GATOR2 complex GO:0061700 9.13 SESN3 SESN2 SESN1
3 TORC2 complex GO:0031932 8.8 SESN3 SESN2 SESN1

Biological processes related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cellular response to glucose starvation GO:0042149 9.58 SESN3 SESN2 SESN1
2 cellular response to amino acid starvation GO:0034198 9.54 SESN3 SESN2 SESN1
3 glucose homeostasis GO:0042593 9.51 SESN3 SESN2
4 positive regulation of macroautophagy GO:0016239 9.5 SESN3 SESN2 SESN1
5 cellular oxidant detoxification GO:0098869 9.49 SESN2 SESN1
6 response to insulin GO:0032868 9.48 SESN3 SESN2
7 cellular response to amino acid stimulus GO:0071230 9.46 SESN3 SESN2
8 reactive oxygen species metabolic process GO:0072593 9.43 SESN2 SESN1
9 negative regulation of TORC1 signaling GO:1904262 9.43 SESN3 SESN2 SESN1
10 cellular response to leucine starvation GO:1990253 9.33 SESN3 SESN2 SESN1
11 cellular response to leucine GO:0071233 9.13 SESN3 SESN2 SESN1
12 regulation of response to reactive oxygen species GO:1901031 8.8 SESN3 SESN2 SESN1

Molecular functions related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.33 SESN3 SESN2 SESN1
2 leucine binding GO:0070728 9.13 SESN3 SESN2 SESN1
3 oxidoreductase activity, acting on peroxide as acceptor GO:0016684 8.8 SESN3 SESN2 SESN1

Sources for Endometrial Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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