MCID: END015
MIFTS: 26

Endometrial Adenosquamous Carcinoma

Categories: Rare diseases, Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Adenosquamous Carcinoma

MalaCards integrated aliases for Endometrial Adenosquamous Carcinoma:

Name: Endometrial Adenosquamous Carcinoma 12 53 15 73
Adenosquamous Carcinoma of the Endometrium 53
Endometrial Adenosquamous Cell Carcinoma 73
Adenosquamous Carcinoma of Endometrium 12
Endometrial Adenosquamous Cancer 53

Classifications:



External Ids:

Disease Ontology 12 DOID:5631

Summaries for Endometrial Adenosquamous Carcinoma

Disease Ontology : 12 An endometrial carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Endometrial Adenosquamous Carcinoma, also known as adenosquamous carcinoma of the endometrium, is related to adenosquamous carcinoma and breast cyst. An important gene associated with Endometrial Adenosquamous Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Lung fibrosis. The drugs Lenograstim and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include endothelial.

Related Diseases for Endometrial Adenosquamous Carcinoma

Diseases related to Endometrial Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 9.9
2 breast cyst 9.8 EGF SERPINA3
3 xanthogranulomatous pyelonephritis 9.8 EGF SERPINA3
4 breast adenocarcinoma 9.4 EGF PLAU
5 alzheimer disease 2 9.4 PLAU SERPINA3
6 adamantinoma of long bones 9.3 EGF PLAU
7 esophageal cancer 9.0 EGF PLAU
8 prostate cancer 8.5 EGF PLAU SERPINA3

Graphical network of the top 20 diseases related to Endometrial Adenosquamous Carcinoma:



Diseases related to Endometrial Adenosquamous Carcinoma

Symptoms & Phenotypes for Endometrial Adenosquamous Carcinoma

Drugs & Therapeutics for Endometrial Adenosquamous Carcinoma

Drugs for Endometrial Adenosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3,Phase 1 135968-09-1
2
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Doxorubicin Approved, Investigational Phase 3,Phase 1 23214-92-8 31703
4
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
5
Doxil Approved June 1999 Phase 3,Phase 1 31703
6 Adjuvants, Immunologic Phase 3,Phase 1
7 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
8 Topoisomerase Inhibitors Phase 3,Phase 1
9 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
10 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
11 Antimitotic Agents Phase 3,Phase 2,Phase 1
12 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
13
Gemcitabine Approved Phase 2 95058-81-4 60750
14
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
15
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
16
Bevacizumab Approved, Investigational Phase 2 216974-75-3
17
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
18
Everolimus Approved Phase 2 159351-69-6 6442177
19
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
20
Cediranib Investigational Phase 2 288383-20-0 9933475
21
Trebananib Investigational Phase 2 894356-79-7
22
Maleic acid Experimental Phase 2 110-16-7 444266
23
Medroxyprogesterone Phase 2 520-85-4 10631
24 Mitogens Phase 2
25 Contraceptive Agents Phase 2
26 Contraceptive Agents, Male Phase 2
27 Contraceptives, Oral Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Endothelial Growth Factors Phase 2
31 Immunoglobulin G Phase 2
32 Antibodies Phase 2
33 Immunoglobulins Phase 2
34 Antibodies, Monoclonal Phase 2
35 Immunosuppressive Agents Phase 2
36 Anti-Infective Agents Phase 2
37 Protein Kinase Inhibitors Phase 2
38 Antimetabolites Phase 2
39 Antiviral Agents Phase 2
40 Antimetabolites, Antineoplastic Phase 2
41 Antineoplastic Agents, Hormonal Phase 2
42 Epothilone B Phase 2
43 Epothilones Phase 2
44 Antifungal Agents Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Combination Chemotherapy Regimens Plus Radiation Therapy in Treating Patients With Stage III or Stage IV Endometrial Cancer Completed NCT00006011 Phase 3 Doxorubicin Hydrochloride;Cisplatin;Paclitaxel
2 Selumetinib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01011933 Phase 2 Selumetinib
3 Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00820898 Phase 2 Gemcitabine Hydrochloride
4 Akt Inhibitor MK2206 in Treating Patients With Recurrent or Advanced Endometrial Cancer Completed NCT01307631 Phase 2 Akt Inhibitor MK2206
5 Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01132820 Phase 2 Cediranib Maleate
6 Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed NCT01210222 Phase 2
7 Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer Completed NCT01005329 Phase 2 Carboplatin;Cisplatin;Paclitaxel
8 Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus Completed NCT00064025 Phase 2 Medroxyprogesterone
9 Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial Cancer Recruiting NCT00492778 Phase 2 Cisplatin
10 Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer Active, not recruiting NCT00977574 Phase 2 Carboplatin;Ixabepilone;Paclitaxel;Temsirolimus
11 Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer Suspended NCT01935934 Phase 2 Cabozantinib S-malate
12 Intraperitoneal Paclitaxel, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Stage III-IV Endometrial Cancer Completed NCT00575952 Phase 1 Cisplatin;Doxorubicin Hydrochloride;Paclitaxel

Search NIH Clinical Center for Endometrial Adenosquamous Carcinoma

Genetic Tests for Endometrial Adenosquamous Carcinoma

Anatomical Context for Endometrial Adenosquamous Carcinoma

MalaCards organs/tissues related to Endometrial Adenosquamous Carcinoma:

41
Endothelial

Publications for Endometrial Adenosquamous Carcinoma

Articles related to Endometrial Adenosquamous Carcinoma:

# Title Authors Year
1
Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis. ( 15723689 )
2005

Variations for Endometrial Adenosquamous Carcinoma

Expression for Endometrial Adenosquamous Carcinoma

Search GEO for disease gene expression data for Endometrial Adenosquamous Carcinoma.

Pathways for Endometrial Adenosquamous Carcinoma

Pathways related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 EGF PLAU SERPINA3
2 10.42 EGF PLAU

GO Terms for Endometrial Adenosquamous Carcinoma

Cellular components related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.33 EGF PLAU SERPINA3
2 extracellular space GO:0005615 9.13 EGF PLAU SERPINA3
3 platelet alpha granule lumen GO:0031093 8.62 EGF SERPINA3

Biological processes related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.16 PLAU SERPINA3
2 positive regulation of cell migration GO:0030335 8.96 EGF PLAU
3 platelet degranulation GO:0002576 8.62 EGF SERPINA3

Sources for Endometrial Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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