MCID: END015
MIFTS: 32

Endometrial Adenosquamous Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Endometrial Adenosquamous Carcinoma

MalaCards integrated aliases for Endometrial Adenosquamous Carcinoma:

Name: Endometrial Adenosquamous Carcinoma 12 54 15 17 74
Adenosquamous Carcinoma of the Endometrium 54
Endometrial Adenosquamous Cell Carcinoma 74
Adenosquamous Carcinoma of Endometrium 12
Endometrial Adenosquamous Cancer 54

Classifications:



External Ids:

Disease Ontology 12 DOID:5631

Summaries for Endometrial Adenosquamous Carcinoma

Disease Ontology : 12 An endometrial carcinoma that derives from squamous cells and gland-like cells.

MalaCards based summary : Endometrial Adenosquamous Carcinoma, also known as adenosquamous carcinoma of the endometrium, is related to adenocarcinoma and neuroendocrine carcinoma. An important gene associated with Endometrial Adenosquamous Carcinoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Lung fibrosis. The drugs Cisplatin and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include cervix, endothelial and testes.

Related Diseases for Endometrial Adenosquamous Carcinoma

Diseases related to Endometrial Adenosquamous Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 10.2
2 neuroendocrine carcinoma 10.1
3 neuroendocrine carcinoma of the cervix 10.1
4 adenosquamous carcinoma 10.1
5 breast cyst 9.9 EGF SERPINA3
6 xanthogranulomatous pyelonephritis 9.9 EGF SERPINA3
7 maxillary cancer 9.8 EGF PLAU
8 breast adenocarcinoma 9.7 EGF PLAU
9 breast disease 9.7 EGF PLAU
10 alzheimer disease 2 9.7 PLAU SERPINA3
11 adamantinoma of long bones 9.7 EGF PLAU
12 lung cancer susceptibility 3 9.5 EGF PLAU
13 prostate cancer 9.3 EGF PLAU SERPINA3

Graphical network of the top 20 diseases related to Endometrial Adenosquamous Carcinoma:



Diseases related to Endometrial Adenosquamous Carcinoma

Symptoms & Phenotypes for Endometrial Adenosquamous Carcinoma

Drugs & Therapeutics for Endometrial Adenosquamous Carcinoma

Drugs for Endometrial Adenosquamous Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Doxorubicin Approved, Investigational Phase 3,Phase 1 23214-92-8 31703
3
Lenograstim Approved, Investigational Phase 3,Phase 1 135968-09-1
4
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
5
Doxil Approved June 1999 Phase 3,Phase 1 31703
6 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
7 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
8 Antimitotic Agents Phase 3,Phase 2,Phase 1
9 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
10 Topoisomerase Inhibitors Phase 3,Phase 1
11 Adjuvants, Immunologic Phase 3,Phase 1
12 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
13 Immunologic Factors Phase 3,Phase 2,Phase 1
14
Gemcitabine Approved Phase 2 95058-81-4 60750
15
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
16
Bevacizumab Approved, Investigational Phase 2 216974-75-3
17
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
18
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 5284616 6436030
19
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
20
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
21
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
22
Cediranib Investigational Phase 2 288383-20-0 9933475
23
Trebananib Investigational Phase 2 894356-79-7
24 Immunosuppressive Agents Phase 2
25 Antimetabolites Phase 2
26 Antiviral Agents Phase 2
27 Anti-Infective Agents Phase 2
28 Antimetabolites, Antineoplastic Phase 2
29 Protein Kinase Inhibitors Phase 2
30 Angiogenesis Modulating Agents Phase 2
31 Angiogenesis Inhibitors Phase 2
32 Immunoglobulins Phase 2
33 Immunoglobulin G Phase 2
34 Endothelial Growth Factors Phase 2
35 Antibodies, Monoclonal Phase 2
36 Mitogens Phase 2
37 Antibodies Phase 2
38 Antineoplastic Agents, Immunological Phase 2
39 Contraceptive Agents, Male Phase 2
40 Contraceptives, Oral Phase 2
41 Contraceptive Agents Phase 2
42 Antineoplastic Agents, Hormonal Phase 2
43
Medroxyprogesterone Phase 2 520-85-4 10631
44 Epothilone B Phase 2
45 Antifungal Agents Phase 2
46 Epothilones Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Combination Chemotherapy Regimens Plus Radiation Therapy in Treating Patients With Stage III or Stage IV Endometrial Cancer Completed NCT00006011 Phase 3 Doxorubicin Hydrochloride;Cisplatin;Paclitaxel
2 Selumetinib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01011933 Phase 2 Selumetinib
3 Gemcitabine in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00820898 Phase 2 Gemcitabine Hydrochloride
4 Akt Inhibitor MK2206 in Treating Patients With Recurrent or Advanced Endometrial Cancer Completed NCT01307631 Phase 2 Akt Inhibitor MK2206
5 Cediranib Maleate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01132820 Phase 2 Cediranib Maleate
6 Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed NCT01210222 Phase 2
7 Intensity-Modulated Radiation Therapy, Cisplatin, and Bevacizumab Followed by Carboplatin and Paclitaxel in Treating Patients Who Have Undergone Surgery for Endometrial Cancer Completed NCT01005329 Phase 2 Carboplatin;Cisplatin;Paclitaxel
8 Medroxyprogesterone in Treating Patients With Endometrioid Adenocarcinoma of the Uterine Corpus Completed NCT00064025 Phase 2 Medroxyprogesterone
9 Radiation Therapy With or Without Cisplatin in Treating Patients With Recurrent Endometrial Cancer Recruiting NCT00492778 Phase 2 Cisplatin
10 Cabozantinib S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer Active, not recruiting NCT01935934 Phase 2 Cabozantinib S-malate
11 Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer Active, not recruiting NCT00977574 Phase 2 Carboplatin;Ixabepilone;Paclitaxel;Temsirolimus
12 Intraperitoneal Paclitaxel, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Stage III-IV Endometrial Cancer Completed NCT00575952 Phase 1 Cisplatin;Doxorubicin Hydrochloride;Paclitaxel

Search NIH Clinical Center for Endometrial Adenosquamous Carcinoma

Genetic Tests for Endometrial Adenosquamous Carcinoma

Anatomical Context for Endometrial Adenosquamous Carcinoma

MalaCards organs/tissues related to Endometrial Adenosquamous Carcinoma:

42
Cervix, Endothelial, Testes, Uterus, Bone, Prostate

Publications for Endometrial Adenosquamous Carcinoma

Articles related to Endometrial Adenosquamous Carcinoma:

(show all 12)
# Title Authors Year
1
Primary neoplasms of the uterus simultaneously presenting as neuroendocrine carcinoma of the cervix and adenosquamous carcinoma of the endometrium: a case report. ( 31023120 )
2019
2
Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis. ( 15723689 )
2005
3
Adenocarcinoma, adenoacanthoma, and mixed adenosquamous carcinoma of the endometrium. ( 11446483 )
2001
4
Paraneoplastic hypercalcemia associated with adenosquamous carcinoma of the endometrium. ( 1989923 )
1991
5
Evaluation of squamous epithelium in adenoacanthoma and adenosquamous carcinoma of the endometrium: immunoperoxidase analysis of involucrin and keratin localization. ( 6203856 )
1984
6
Oestrogen excretion and ovarian pathology in postmenopausal women with atypical hyperplasia, adenocarcinoma and mixed adenosquamous carcinoma of the endometrium. ( 843487 )
1977
7
Adenosquamous carcinoma of the endometrium. An entity with an inherent poor prognosis? ( 880545 )
1977
8
Adenosquamous carcinoma of the endometrium. ( 1002838 )
1976
9
Test and teach number eight. Diagnosis: mixed adenosquamous carcinoma of the endometrium. ( 1004945 )
1976
10
Mixed (adenosquamous) carcinoma of the endometrium: electron microscopic observations. ( 4120024 )
1973
11
Mixed adenosquamous carcinoma of the endometrium. ( 4709077 )
1973
12
Adenoacanthoma and mixed adenosquamous carcinoma of the endometrium. A clinicopathologic study. ( 5083064 )
1972

Variations for Endometrial Adenosquamous Carcinoma

Expression for Endometrial Adenosquamous Carcinoma

Search GEO for disease gene expression data for Endometrial Adenosquamous Carcinoma.

Pathways for Endometrial Adenosquamous Carcinoma

Pathways related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 EGF PLAU SERPINA3
2 10.42 EGF PLAU

GO Terms for Endometrial Adenosquamous Carcinoma

Cellular components related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 EGF PLAU SERPINA3
2 extracellular exosome GO:0070062 9.33 EGF PLAU SERPINA3
3 extracellular space GO:0005615 9.13 EGF PLAU SERPINA3
4 platelet alpha granule lumen GO:0031093 8.62 EGF SERPINA3

Biological processes related to Endometrial Adenosquamous Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.16 PLAU SERPINA3
2 positive regulation of cell migration GO:0030335 8.96 EGF PLAU
3 platelet degranulation GO:0002576 8.62 EGF SERPINA3

Sources for Endometrial Adenosquamous Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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