MCID: END080
MIFTS: 45

Endometrial Disease

Categories: Reproductive diseases

Aliases & Classifications for Endometrial Disease

MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 15
Endometrial Disorder 54 71
Endometrial Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1005
NCIt 49 C3504
UMLS 71 C0151622 C1720816

Summaries for Endometrial Disease

Disease Ontology : 12 A uterine disease that is located in the endometrium.

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to endometritis and endometriosis. An important gene associated with Endometrial Disease is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Mepivacaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include endometrium, breast and bone, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Endometrial Disease

Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 434)
# Related Disease Score Top Affiliating Genes
1 endometritis 31.2 TNF TLR4 TLR2 SIGLEC5 SDC1 OXT
2 endometriosis 30.2 PTGS2 IL6 IL1B ESR1 CYP19A1 CXCL8
3 adenomyosis 29.9 PTGS2 OXT ESR1 CYP19A1 CXCL8
4 pre-eclampsia 29.6 TNF TLR4 OXT IL6 IL1B CXCL8
5 tamoxifen-related endometrial lesion 11.1
6 granulomatous endometritis 10.6 SDC1 ESR1
7 breast juvenile papillomatosis 10.6 OXT ESR1
8 external pathological resorption 10.6 TNF IL6
9 postmenopausal atrophic vaginitis 10.6 OXT ESR1 CYP19A1
10 mycobacterium chelonae 10.6 TLR2 CXCL8
11 scorpion envenomation 10.6 TNF IL6
12 angelucci's syndrome 10.6 IL1B CXCL8
13 dermatitis, atopic, 8 10.6 IL1B CXCL8
14 systemic onset juvenile idiopathic arthritis 10.6 TNF IL1B
15 mycobacterium marinum 10.5 TLR2 CXCL8
16 staphylococcal toxic shock syndrome 10.5 TNF IL1B
17 acute transverse myelitis 10.5 IL6 CXCL8
18 osteosclerotic myeloma 10.5 IL6 IL1B
19 periodontitis, chronic 10.5 IL6 IL1B
20 vulvar vestibulitis syndrome 10.5 TNF IL1B ESR1
21 mycobacterium kansasii 10.5 TLR2 CXCL8
22 esophagus melanoma 10.5 IL1B CXCL8
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
24 myelitis 10.5 TNF IL6 CXCL8
25 recurrent corneal erosion 10.5 IL6 IL1B CXCL8
26 pustulosis of palm and sole 10.5 TNF SIGLEC5 CXCL8
27 leukoregulin 10.5 PTGS2 CXCL8
28 idiopathic anterior uveitis 10.5 TNF IL6 CXCL8
29 estrogen-receptor negative breast cancer 10.5 ESR1 CYP19A1 CXCL8
30 streptococcal toxic-shock syndrome 10.5 TNF IL6 CXCL8
31 uremic pruritus 10.5 IL6 IL1B
32 palladium allergic contact dermatitis 10.5 TNF IL1B
33 pouchitis 10.5 TLR4 CXCL8
34 funisitis 10.5 IL6 IL1B CXCL8
35 kashin-beck disease 10.5 TNF IL1B
36 conjunctivochalasis 10.5 IL6 IL1B CXCL8
37 post-cardiac arrest syndrome 10.5 SDC1 IL6 CXCL8
38 ascaris lumbricoides infection 10.5 IL6 IL1B CXCL8
39 stachybotrys chartarum 10.5 TNF IL6 IL1B
40 eales disease 10.5 TNF IL6 IL1B
41 meningococcal meningitis 10.5 TLR4 TLR2 SIGLEC5
42 cardiac sarcoidosis 10.5 TNF IL1B CXCL8
43 cervical incompetence 10.5 OXT MFN2 IL6
44 cysticercosis 10.5 TLR4 IL6 IL1B
45 transverse myelitis 10.5 TNF IL6 CXCL8
46 encephalomalacia 10.5 TLR4 IL6 IL1B
47 opisthorchiasis 10.5 TNF IL1B CXCL8
48 acute generalized exanthematous pustulosis 10.5 PTGS2 CXCL8
49 laryngitis 10.5 TNF IL6 IL1B
50 congenital cytomegalovirus 10.5 TNF TLR2 IL1B

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease

Symptoms & Phenotypes for Endometrial Disease

MGI Mouse Phenotypes related to Endometrial Disease:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 CYP19A1 ERRFI1 ESR1 HP IL1B IL6
2 hematopoietic system MP:0005397 10.39 CYP19A1 ERRFI1 ESR1 HP IL1B IL6
3 immune system MP:0005387 10.38 CYP19A1 ERRFI1 ESR1 HP IFI30 IL1B
4 homeostasis/metabolism MP:0005376 10.37 CYP19A1 ERRFI1 ESR1 HP IL1B IL6
5 behavior/neurological MP:0005386 10.34 CYP19A1 ERRFI1 ESR1 IL6 MFN2 OXT
6 integument MP:0010771 10.23 CYP19A1 ERRFI1 ESR1 IL1B IL6 OXT
7 endocrine/exocrine gland MP:0005379 10.22 CYP19A1 ERRFI1 ESR1 IL6 OXT PTGS2
8 digestive/alimentary MP:0005381 10.19 CYP19A1 ERRFI1 ESR1 IL6 OXT PTGS2
9 adipose tissue MP:0005375 10.17 CYP19A1 ESR1 IL6 OXT PTGS2 TLR2
10 neoplasm MP:0002006 10.11 ERRFI1 ESR1 HP IL1B IL6 PTGS2
11 liver/biliary system MP:0005370 10.09 CYP19A1 ERRFI1 ESR1 HP IL6 PTGS2
12 muscle MP:0005369 10.06 CYP19A1 ESR1 IL6 MFN2 PTGS2 TLR2
13 nervous system MP:0003631 10.06 CYP19A1 ESR1 IL1B IL6 MFN2 OXT
14 renal/urinary system MP:0005367 9.91 CYP19A1 ERRFI1 ESR1 HP IL6 OXT
15 reproductive system MP:0005389 9.9 CYP19A1 ERRFI1 ESR1 IL6 OXT PTGS2
16 respiratory system MP:0005388 9.56 ERRFI1 ESR1 IL6 PTGS2 TLR2 TLR3
17 skeleton MP:0005390 9.32 CYP19A1 ERRFI1 ESR1 IL1B IL6 MFN2

Drugs & Therapeutics for Endometrial Disease

Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
3 Anesthetics, Local Phase 4
4 Anesthetics Phase 4
5 Central Nervous System Depressants Phase 4
6 Pharmaceutical Solutions Phase 4
7
Tamoxifen Approved Phase 3 10540-29-1 2733526
8
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
9
Sodium citrate Approved, Investigational Phase 3 68-04-2
10
Misoprostol Approved Phase 3 59122-46-2 5282381
11
Megestrol acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 595-33-5 11683
12
Levonorgestrel Approved, Investigational Phase 2, Phase 3 797-63-7, 17489-40-6 13109
13
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
14 Estrogens Phase 3
15 Citrate Phase 3
16 Selective Estrogen Receptor Modulators Phase 3
17 Hormone Antagonists Phase 3
18 Contraceptive Agents, Male Phase 3
19
Medroxyprogesterone Phase 3 520-85-4 10631
20 Estrogen Antagonists Phase 3
21 Estrogen Receptor Antagonists Phase 3
22 Estrogen Receptor Modulators Phase 3
23 Gastrointestinal Agents Phase 3
24 Oxytocics Phase 3
25 Anti-Ulcer Agents Phase 3
26 Antacids Phase 3
27 Contraceptive Agents Phase 2, Phase 3
28 Contraceptives, Oral Phase 2, Phase 3
29 Antineoplastic Agents, Hormonal Phase 2, Phase 3
30 Hormones Phase 2, Phase 3
31 Central Nervous System Stimulants Phase 2, Phase 3
32
Megestrol Phase 2, Phase 3 3562-63-8 19090 3080587
33 Appetite Stimulants Phase 2, Phase 3
34
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
35
Lenograstim Approved, Investigational Phase 2 135968-09-1
36
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
37 Immunologic Factors Phase 2
38 Albumin-Bound Paclitaxel Phase 2
39 Antimitotic Agents Phase 2
40 Adjuvants, Immunologic Phase 2
41
protease inhibitors
42 HIV Protease Inhibitors

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Randomized Double-blind Placebo Controlled Trial to Assess the Role of Intrauterine Cornual Block (ICOB) in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 A Randomized Comparison Of Medroxyprogesterone Acetate (MA) And Observation For Prevention Of Endometrial Pathology In Postmenopausal Breast Cancer Patients Treated With Tamoxifen, Phase III Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
3 A Randomized Comparison of Oral, Sublingual and Vaginal Misoprostol Administration in Premenopausal Women Before Operative Hysteroscopy Completed NCT01805115 Phase 3 Oral misoprostol;Sublingual misoprostol;Vaginal misoprostol;Control
4 Megestrol Acetate Plus LNG-IUS to Megestrol Acetate in Young Women With Early Endometrial Cancer Recruiting NCT03241914 Phase 2, Phase 3 Megestrol Acetate
5 Phase II Study of Weekly Paclitaxel/Carboplatin in Combination With Prophylactic G-CSF in the Treatment of Gynaecological Cancers Completed NCT01523678 Phase 2 Filgrastim;Paclitaxel;Carboplatin
6 A Single Arm Phase II Trial of BMN 673 for Inoperable, Advanced Endometrial Cancer With Retrospective PTEN, MSI and MRE11 Analysis Withdrawn NCT02127151 Phase 2 BMN 673
7 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Unknown status NCT02691715
8 Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Unknown status NCT03351673
9 REM (Risk Of Endometrial Malignancy): A Proposal for a New Scoring System to Evaluate Risk of Endometrial Malignancy Completed NCT01830192
10 Evaluation of Serum Human Epididymis Secretory Protein 4 (HE4) in Benign Endometrial Disease and Endometrial Cancer Completed NCT03456791
11 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Recruiting NCT03289468
12 HE4 is a Beneficial Biomarker in Endometrial Cancer Recruiting NCT03459976
13 Endometrial and Isthmic Microbiota During IVF Stimulation in Patients Affected With Isthmocele and Intrauterine Mucus Secretion After C-section. Active, not recruiting NCT03519763
14 Low Level Laser Therapy to Endometrial Cells: A Novel Approach to Increase Endometrial Proliferation and Enhance Endometrial Receptivity Available NCT02764034

Search NIH Clinical Center for Endometrial Disease

Genetic Tests for Endometrial Disease

Anatomical Context for Endometrial Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Disease:

19
Endometrium

MalaCards organs/tissues related to Endometrial Disease:

40
Breast, Bone, Liver, Ovary, Lymph Node, Eye, Lung

Publications for Endometrial Disease

Articles related to Endometrial Disease:

(show top 50) (show all 185)
# Title Authors PMID Year
1
[Analysis of influencing factors of endometrial disease of patients with breast cancer after operation]. 61
31874475 2019
2
Preoperative platelet morphology parameters as prognostic predictors for endometrial malignant carcinoma stage and progesterone receptor. 61
31764773 2019
3
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening. 61
31371824 2019
4
More Than Just 2 Layers: A Comprehensive Multimodality Imaging Review of Endometrial Abnormalities. 61
31307863 2019
5
Cell and biomaterial-based approaches to uterus regeneration. 61
31198582 2019
6
The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker. 61
30851892 2019
7
The Impact of Gynaecological Tumour Board Rounds on Patient Care. 61
30393059 2019
8
Event-free survival following early endometrial events in breast cancer patients treated with anti-hormonal therapy: A nationwide claims data study. 61
30633178 2019
9
The CXL12/CXCR4/CXCR7 axis in female reproductive tract disease: Review. 61
30106199 2018
10
Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway. 61
30392973 2018
11
A phase I/II study of GLIF combination chemotherapy for taxane/platinum-refractory/resistant endometrial cancer (GOGO-EM2). 61
30030584 2018
12
Comparison of endometrial assessment by transvaginal ultrasonography and hysteroscopy. 61
29904926 2018
13
Evaluation of complete blood count parameters to predict endometrial cancer. 61
29604099 2018
14
Implementing the Risk of Endometrial Malignancy Algorithm (REM) adding obesity as a predictive factor: Results of REM-B in a single-center survey. 61
29660578 2018
15
Therapeutic strategies involving uterine stem cells in reproductive medicine. 61
29652725 2018
16
Endometrial histopathology results and evaluation of endometrial cancer risk in geriatric women. 61
29725280 2018
17
Metabolomic Signature of Endometrial Cancer. 61
29235868 2018
18
Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature. 61
29295713 2018
19
Elevated Prevalence of Polycystic Ovary Syndrome and Cardiometabolic Disease in South Asian Infertility Patients. 61
27351893 2017
20
Nuclear factor-κB expression in the endometrium of normal and overweight women with polycystic ovary syndrome. 61
28617068 2017
21
Validation of REM score to predict endometrial cancer in patients with ultrasound endometrial abnormalities: results of a new independent dataset. 61
28389908 2017
22
Evaluating the Age Cutoff Criterion for Reporting Benign-Appearing Endometrial Cells in Routine Pap Tests: An 8-Year Retrospective Review. 61
28486237 2017
23
Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. 61
27895728 2016
24
Correlation between Cyr61 expression and clinicopathologic parameters in adenomyosis. 61
27644084 2016
25
Differentiation between endometrial carcinoma and atypical endometrial hyperplasia with transvaginal sonographic elastography. 61
26711550 2016
26
The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis. 61
26748390 2016
27
Stage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy? 61
27172750 2016
28
Could in-vitro studies on Ishikawa cell lines explain the endometrial safety of raloxifene? Systematic literature review and starting points for future oncological research. 61
25536299 2015
29
Endometrial Ablation in Women With Abnormal Uterine Bleeding Related to Ovulatory Dysfunction: A Cohort Study. 61
26149205 2015
30
Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. 61
26253321 2015
31
Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia. 61
25536958 2015
32
Estrogen receptor β: the guardian of the endometrium. 61
25305176 2015
33
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. 61
25297546 2014
34
Performance of multidetector CT in the evaluation of the endometrium: Measurement of endometrial thickness and detection of disease. 61
25060929 2014
35
Circulating endometrial cells in peripheral blood. 61
25195200 2014
36
Influence of AKT on progesterone action in endometrial diseases. 61
25100707 2014
37
Recurrent postmenopausal bleeding: a prospective cohort study. 61
24681065 2014
38
Surgical management of early endometrial cancer: an update and proposal of a therapeutic algorithm. 61
25063051 2014
39
Role of hysteroscopy prior to assisted reproduction techniques. 61
24067621 2014
40
Experience and results of office hysteroscopy at a primary hospital. 61
24359051 2014
41
Tissue and circulating microRNA influence reproductive function in endometrial disease. 61
24055529 2013
42
Abnormal vaginal bleeding following pharmacist prescribing of metformin leads to the detection of complex endometrial hyperplasia. 61
24285770 2013
43
Histopathologic assessment of the entire endometrium in asymptomatic women. 61
23938162 2013
44
REM (risk of endometrial malignancy): a proposal for a new scoring system to evaluate risk of endometrial malignancy. 61
23983254 2013
45
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. 61
23824412 2013
46
Cancer risk and PCOS. 61
23624028 2013
47
Endometrial surveillance in tamoxifen users: role, timing and accuracy of hysteroscopic investigation: observational longitudinal cohort study. 61
23629476 2013
48
Angiogenesis, lymphangiogenesis and neurogenesis in endometriosis. 61
23747918 2013
49
Development of endometrial carcinoma in a patient with leprechaunism (donohue syndrome). 61
23990696 2013
50
Laparoendoscopic single-site surgery with hysterectomy in patients with prior cesarean section: comparison of surgical outcomes with bladder dissection techniques. 61
23317681 2013

Variations for Endometrial Disease

Expression for Endometrial Disease

Search GEO for disease gene expression data for Endometrial Disease.

Pathways for Endometrial Disease

Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 TNF TLR6 TLR4 TLR3 TLR2 TLR1
2
Show member pathways
13.47 TNF TLR6 TLR4 TLR3 TLR2 TLR1
3
Show member pathways
13.26 TNF TLR6 TLR4 TLR3 TLR2 TLR1
4
Show member pathways
13.2 TNF TLR6 TLR4 TLR3 TLR2 TLR1
5
Show member pathways
13.04 TNF TLR4 TLR3 TLR2 PTGS2 IL6
6
Show member pathways
13.02 TNF TLR4 TLR3 TLR2 PTGS2 IL6
7
Show member pathways
12.91 TNF TLR4 TLR3 TLR2 IL6 IL1B
8
Show member pathways
12.88 TNF IL6 IL1B IFI30 CXCL8
9
Show member pathways
12.84 TNF TLR4 TLR3 IL6 IL1B CXCL8
10 12.83 TNF TLR3 TLR2 IL6 IL1B
11
Show member pathways
12.77 TNF TLR6 TLR4 TLR3 TLR2 TLR1
12
Show member pathways
12.67 TNF TLR6 TLR4 TLR3 TLR2 TLR1
13
Show member pathways
12.65 TNF TLR4 TLR2 IL6 IL1B
14
Show member pathways
12.65 TNF TLR4 TLR2 IL6 IL1B
15 12.64 TNF TLR6 TLR3 TLR2 TLR1 PTGS2
16
Show member pathways
12.48 TLR6 TLR4 TLR3 TLR2 TLR1
17
Show member pathways
12.44 TNF TLR2 PTGS2 IL6 IL1B CXCL8
18 12.41 TNF TLR4 IL1B CXCL8
19 12.39 TNF TLR4 TLR2 SDC1 ESR1
20 12.38 TNF TLR4 IL6 IL1B CXCL8
21
Show member pathways
12.36 TNF PTGS2 IL6 IL1B
22
Show member pathways
12.34 TNF TLR4 TLR2 PTGS2 IL1B
23 12.34 TNF TLR4 MFN2 IL6 IL1B CXCL8
24
Show member pathways
12.33 TNF TLR4 TLR3 SDC1 PTGS2 IL6
25
Show member pathways
12.31 TNF TLR2 PTGS2 IL6 IL1B CXCL8
26
Show member pathways
12.26 TNF TLR4 TLR3 IL1B
27
Show member pathways
12.26 TNF PTGS2 IL6 IL1B
28 12.26 TNF TLR6 TLR4 TLR2 TLR1 IL6
29
Show member pathways
12.25 TNF TLR6 TLR4 TLR3 TLR2 TLR1
30 12.23 TNF IL6 IL1B CXCL8
31 12.14 TNF TLR6 TLR4 TLR3 TLR2 TLR1
32 12.12 TNF TLR4 IL6 IL1B CXCL8
33
Show member pathways
12.11 TLR6 TLR4 TLR3 TLR2 TLR1 IL1B
34 12.1 TNF PTGS2 IL6 IL1B CXCL8
35
Show member pathways
12.08 TNF TLR6 TLR4 TLR2 TLR1 IL6
36 12.07 TNF TLR4 PTGS2 IL6 IL1B CXCL8
37 12.05 TNF PTGS2 IL6 IL1B
38 12.04 TNF TLR4 PTGS2 IL1B CXCL8
39 11.99 TNF IL6 IL1B CXCL8
40 11.98 TNF TLR4 TLR2 IL6 IL1B CXCL8
41 11.94 TLR6 TLR4 TLR3 TLR2 TLR1
42 11.92 TNF TLR4 TLR2 IL6 IL1B CXCL8
43 11.88 TLR4 IL6 IL1B CXCL8
44
Show member pathways
11.87 TNF TLR6 TLR4 TLR3 TLR2 TLR1
45 11.85 TNF TLR4 IL6 IL1B CXCL8
46 11.82 TNF PTGS2 IL6 IL1B
47
Show member pathways
11.79 TNF PTGS2 CXCL8
48 11.78 TNF IL6 IL1B
49 11.76 TNF IL6 IL1B CXCL8
50
Show member pathways
11.76 TNF PTGS2 IL6 IL1B CXCL8

GO Terms for Endometrial Disease

Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.46 TNF TLR6 TLR2 TLR1
2 phagocytic vesicle membrane GO:0030670 9.13 TLR6 TLR2 TLR1
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR2 TLR1

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.32 TLR6 TLR4 TLR3 TLR2 TLR1 PTGES
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 TNF TLR4 TLR3 TLR2 IL6 IL1B
3 negative regulation of cell proliferation GO:0008285 10.15 TLR2 PTGS2 PTGES IL6 IL1B CXCL8
4 positive regulation of gene expression GO:0010628 10.12 TNF TLR6 TLR4 TLR3 TLR2 IL6
5 immune response GO:0006955 10.1 TNF TLR6 TLR4 TLR2 TLR1 IL6
6 defense response to bacterium GO:0042742 10.09 TNF TLR6 TLR4 TLR3 HP
7 cytokine-mediated signaling pathway GO:0019221 10.07 TNF SDC1 PTGS2 IL6 IL1B CXCL8
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.04 TNF TLR6 TLR4 TLR3 IL1B
9 cellular response to lipopolysaccharide GO:0071222 10.04 TNF TLR4 IL6 IL1B CXCL8
10 response to lipopolysaccharide GO:0032496 10.03 TLR4 TLR2 PTGS2 PTGES IL1B
11 defense response GO:0006952 10.03 TNF TLR3 TLR1 HP CXCL8
12 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL1B ESR1
13 response to organic substance GO:0010033 9.97 TNF SDC1 PTGS2 HP
14 positive regulation of JNK cascade GO:0046330 9.96 TNF TLR4 TLR3 IL1B
15 regulation of inflammatory response GO:0050727 9.96 TNF TLR4 PTGS2 ESR1
16 cellular response to mechanical stimulus GO:0071260 9.96 TLR4 TLR3 PTGS2 IL1B
17 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.92 TNF TLR4 TLR3
18 apoptotic signaling pathway GO:0097190 9.92 TNF TLR4 TLR3
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF PTGS2 IL6
20 positive regulation of inflammatory response GO:0050729 9.91 TNF TLR4 TLR3 TLR2 IL1B
21 positive regulation of tumor necrosis factor production GO:0032760 9.9 TLR4 TLR3 TLR2
22 positive regulation of interferon-gamma production GO:0032729 9.9 TNF TLR4 IL1B
23 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.88 TLR6 TLR4 TLR3
24 positive regulation of vascular endothelial growth factor production GO:0010575 9.88 PTGS2 IL6 IL1B
25 response to glucocorticoid GO:0051384 9.88 TNF SDC1 PTGS2 OXT IL6
26 negative regulation of neurogenesis GO:0050768 9.87 TNF IL6 IL1B
27 positive regulation of interleukin-12 production GO:0032735 9.87 TLR4 TLR3 TLR2
28 positive regulation of interferon-beta production GO:0032728 9.87 TLR4 TLR3 TLR2
29 positive regulation of interleukin-6 secretion GO:2000778 9.87 TNF TLR4 TLR2 IL1B
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 TNF TLR4 TLR2 IL1B
31 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 TLR6 TLR4 TLR2 TLR1
32 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 TNF TLR4 TLR3 TLR2 IL1B
33 positive regulation of glial cell proliferation GO:0060252 9.83 TNF IL6 IL1B
34 microglial cell activation GO:0001774 9.83 TNF TLR6 TLR3 TLR2
35 positive regulation of interleukin-8 secretion GO:2000484 9.82 TLR4 TLR2 TLR1
36 positive regulation of neuroinflammatory response GO:0150078 9.8 TNF IL6 IL1B
37 positive regulation of nitric oxide biosynthetic process GO:0045429 9.8 TNF TLR6 TLR4 PTGS2 IL1B
38 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNF TLR6 TLR4 TLR3 TLR2 IL6
39 regulation of cytokine secretion GO:0050707 9.79 TLR6 TLR2 TLR1
40 I-kappaB phosphorylation GO:0007252 9.79 TLR4 TLR3 TLR2
41 cell activation GO:0001775 9.78 TLR6 TLR2 TLR1
42 positive regulation of chemokine biosynthetic process GO:0045080 9.77 TNF TLR3 IL1B
43 toll-like receptor signaling pathway GO:0002224 9.77 TLR6 TLR4 TLR3 TLR2 TLR1
44 macrophage activation GO:0042116 9.75 TLR4 TLR1
45 cyclooxygenase pathway GO:0019371 9.75 PTGS2 PTGES
46 regulation of neuroinflammatory response GO:0150077 9.75 PTGS2 IL6
47 cellular response to lipoteichoic acid GO:0071223 9.75 TLR4 TLR2
48 interleukin-1 beta secretion GO:0050702 9.75 TLR6 TLR4
49 negative regulation of lipid storage GO:0010888 9.75 TNF IL6
50 positive regulation of interferon-beta biosynthetic process GO:0045359 9.74 TLR4 TLR3

Molecular functions related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.76 TNF TLR6 TLR4 TLR3 TLR2 TLR1
2 cytokine activity GO:0005125 9.71 TNF IL6 IL1B CXCL8
3 transmembrane signaling receptor activity GO:0004888 9.67 TLR6 TLR4 TLR3 TLR1
4 amyloid-beta binding GO:0001540 9.61 TLR6 TLR4 TLR2
5 signaling receptor activity GO:0038023 9.35 TLR6 TLR4 TLR3 TLR2 TLR1
6 lipopolysaccharide receptor activity GO:0001875 9.32 TLR4 TLR2
7 Toll-like receptor 2 binding GO:0035663 9.26 TLR6 TLR1
8 lipopeptide binding GO:0071723 8.8 TLR6 TLR2 TLR1

Sources for Endometrial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....