MCID: END080
MIFTS: 48

Endometrial Disease

Categories: Reproductive diseases

Aliases & Classifications for Endometrial Disease

MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 15
Endometrial Disorder 55 73
Endometrial Diseases 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1005
NCIt 50 C3504

Summaries for Endometrial Disease

Disease Ontology : 12 A uterine disease that is located in the endometrium.

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to endometritis and endometriosis. An important gene associated with Endometrial Disease is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Akt Signaling and Human cytomegalovirus infection. The drugs Mepivacaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and ovary, and related phenotypes are cardiovascular system and adipose tissue

Related Diseases for Endometrial Disease

Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 endometritis 30.4 TNF PGF OXT IL6 IL1B HP
2 endometriosis 29.1 PTGS2 IL6 IL1B ESR1 CYP19A1 CXCL8
3 tamoxifen-related endometrial lesion 10.9
4 mammographic density 10.3 CYP19A1 ESR1
5 progesterone-receptor positive breast cancer 10.3 CYP19A1 ESR1
6 gender identity disorder 10.3 CYP19A1 ESR1
7 estrogen excess 10.3 CYP19A1 ESR1
8 campylobacteriosis 10.3 IL1B TLR4
9 peptic esophagitis 10.3 CXCL8 IL1B
10 pouchitis 10.3 CXCL8 TLR4
11 periodontitis, chronic 10.2 IL1B IL6
12 euthyroid sick syndrome 10.2 IL1B IL6
13 uremic pruritus 10.2 IL1B IL6
14 denture stomatitis 10.2 CXCL8 IL6
15 papillary conjunctivitis 10.2 CXCL8 IL6
16 acute monoblastic leukemia 10.2 CXCL8 IL6
17 acute transverse myelitis 10.2 CXCL8 IL6
18 leukoregulin 10.2 CXCL8 PTGS2
19 melancholia 10.2 HP TNF
20 retinitis pigmentosa 60 10.2 IL1B TNF
21 kashin-beck disease 10.2 IL1B TNF
22 burns 10.2 IL1B TNF
23 irritant dermatitis 10.2 IL1B TNF
24 rheumatoid lung disease 10.2 IL1B TNF
25 congenital cytomegalovirus 10.2 IL1B TNF
26 prosthetic joint infection 10.2 IL1B TLR4
27 tungiasis 10.2 CXCL8 TNF
28 trichuriasis 10.2 CXCL8 TNF
29 cardiac sarcoidosis 10.2 CXCL8 TNF
30 clonorchiasis 10.2 CXCL8 TNF
31 vaginal discharge 10.1 DSPP HP PGF
32 retinitis pigmentosa 55 10.1 IL6 TNF
33 postmenopausal atrophic vaginitis 10.1 ESR1 OXT
34 critical limb ischemia 10.1 IL6 TNF
35 juvenile ankylosing spondylitis 10.1 IL6 TNF
36 null-cell leukemia 10.1 IL6 TNF
37 anca-associated vasculitis 10.1 IL6 TNF
38 posterior urethral valves 10.1 IL6 TNF
39 cardiogenic shock 10.1 IL6 TNF
40 ovarian disease 10.1 CYP19A1 ESR1 TNF
41 breast disease 10.1 CYP19A1 ESR1 TNF
42 alcoholic gastritis 10.1 IL1B PTGS2
43 recurrent corneal erosion 10.1 CXCL8 IL1B IL6
44 bagassosis 10.1 CXCL8 IL1B IL6
45 adenomyosis 10.1 CYP19A1 ESR1 PTGS2
46 cysticercosis 10.1 IL1B IL6 TLR4
47 acute pyelonephritis 10.1 CXCL8 IL6 PGF
48 funisitis 10.1 CXCL8 IL1B IL6
49 pyelitis 10.1 CXCL8 IL6 TLR4
50 bacteriuria 10.1 CXCL8 IL6 TLR4

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease

Symptoms & Phenotypes for Endometrial Disease

MGI Mouse Phenotypes related to Endometrial Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 CYP19A1 ESR1 HP IL1B IL6 OXT
2 adipose tissue MP:0005375 10.1 CYP19A1 ESR1 IL6 OXT PGF PTGS2
3 homeostasis/metabolism MP:0005376 10.1 CYP19A1 ESR1 HP IL1B IL6 OXT
4 hematopoietic system MP:0005397 10.09 CYP19A1 ESR1 HP IL1B IL6 NLRC5
5 immune system MP:0005387 10.07 CYP19A1 ESR1 HP IL1B IL6 NLRC5
6 digestive/alimentary MP:0005381 10 CYP19A1 ESR1 IL6 OXT PTGS2 TLR4
7 integument MP:0010771 9.97 CYP19A1 ESR1 IL1B IL6 OXT PGF
8 liver/biliary system MP:0005370 9.8 CYP19A1 ESR1 HP IL6 PTGS2 TLR4
9 neoplasm MP:0002006 9.76 ESR1 HP IL1B IL6 PGF PTGS2
10 renal/urinary system MP:0005367 9.5 CYP19A1 ESR1 HP IL6 OXT PTGS2
11 respiratory system MP:0005388 9.1 ESR1 IL6 PGF PTGS2 TLR4 TNF

Drugs & Therapeutics for Endometrial Disease

Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3 Pharmaceutical Solutions Phase 4
4 Anesthetics Phase 4
5 Peripheral Nervous System Agents Phase 4
6 Central Nervous System Depressants Phase 4
7 Anesthetics, Local Phase 4
8
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
9
Lenograstim Approved, Investigational Phase 2 135968-09-1
10
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
11 Antineoplastic Agents, Phytogenic Phase 2
12 Antimitotic Agents Phase 2
13 Adjuvants, Immunologic Phase 2
14 Immunologic Factors Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 HIV Protease Inhibitors
17
protease inhibitors
18 Epoetin alfa 113427-24-0
19 Hematinics

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Role of Intrauterine Cornual Block in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity Not yet recruiting NCT03755973 Phase 4 CFA;rFSH
3 Weekly Paclitaxel/Carboplatin With Neupogen in Gynaecological Cancers Active, not recruiting NCT01523678 Phase 2 Filgrastim;Paclitaxel;Carboplatin
4 A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer Withdrawn NCT02127151 Phase 2 BMN 673
5 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Unknown status NCT02691715 Not Applicable
6 REM (Risk Of Endometrial Malignancy) Completed NCT01830192 Not Applicable
7 Human Epididymis Protein 4 in Endometrial Carcinoma Completed NCT03456791
8 Proliferative Effects of Erythropoietin on Human Endometrium Completed NCT03060603 Erythropoietin
9 Fast Versus Slow Tenaculum Placement Completed NCT02716636 Not Applicable
10 Efficacy and Tolerability Study of ZP-025 Vaginal Gel for the Treatment of Vaginal Dryness Completed NCT02994342 Not Applicable
11 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Recruiting NCT03289468
12 Intrauterine Microbiota During IVF in Patients Affected With Isthmocele. Recruiting NCT03519763
13 HE4 is a Beneficial Biomarker in Endometrial Cancer Recruiting NCT03459976
14 Endometrial Injury In Recurrent Implantation Failure Recruiting NCT03748238 Not Applicable
15 Can the iKnife Distinguish Between Normal and Malignant Endometrial Tissue? Recruiting NCT03207074 Not Applicable
16 Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss Recruiting NCT03027479 Not Applicable
17 Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance Not yet recruiting NCT03756480

Search NIH Clinical Center for Endometrial Disease

Genetic Tests for Endometrial Disease

Anatomical Context for Endometrial Disease

MalaCards organs/tissues related to Endometrial Disease:

41
Breast, Bone, Ovary, Lung, Heart, Lymph Node, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Disease:

19
The Endometrium

Publications for Endometrial Disease

Articles related to Endometrial Disease:

(show all 35)
# Title Authors Year
1
Tissue and circulating microRNA influence reproductive function in endometrial disease. ( 24055529 )
2013
2
Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. ( 22384417 )
2011
3
Progesterone resistance and endometrial disease. Preface. ( 20104423 )
2010
4
Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model. ( 19328470 )
2010
5
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. ( 19439667 )
2009
6
Performance of office hysteroscopy and endometrial biopsy for detecting endometrial disease in women at risk of human non-polyposis colon cancer: a prospective study. ( 18217965 )
2008
7
The role of Pipelle Mark II sampling in endometrial disease diagnosis. ( 17029754 )
2007
8
Reproducibility of endometrial vascular patterns in endometrial disease as assessed by transvaginal power Doppler sonography in women with postmenopausal bleeding. ( 16439778 )
2006
9
Clinical inquiries. Can transvaginal ultrasound detect endometrial disease among asymptomatic postmenopausal patients? ( 15581447 )
2004
10
Is pipelle biopsy really adequate for diagnosing endometrial disease? ( 15173672 )
2004
11
Outpatient hysteroscopy and ultrasonography in the management of endometrial disease. ( 15232484 )
2004
12
Evaluation of outpatient hysteroscopy and ultrasonography in the diagnosis of endometrial disease. ( 12052590 )
2002
13
Transvaginal uterine ultrasonography compared with endometrial biopsy for the detection of endometrial disease in perimenopausal women with uterine bleeding. ( 12168877 )
2002
14
Diagnosis of premalignant endometrial disease. ( 11986334 )
2002
15
An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. ( 11174482 )
2001
16
Role of aromatase in endometrial disease. ( 11850203 )
2001
17
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11354070 )
2001
18
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11084170 )
2000
19
Is endometriosis an endometrial disease? ( 10869783 )
2000
20
Endometrial disease diagnosed by transvaginal ultrasound and dilatation and curettage. ( 10326888 )
1999
21
Endometrial thickness in tamoxifen-treated patients: an independent predictor of endometrial disease. ( 10362171 )
1999
22
Ultrasonographic evaluation of endometrial disease in postmenopausal patients with breast cancer and tamoxifen treatment. ( 9914614 )
1999
23
Prediction of benign and malignant endometrial disease: hysterosonographic-pathologic correlation. ( 10207420 )
1999
24
Cervical cytology in menopausal women at high risk for endometrial disease. ( 9818777 )
1998
25
Transvaginal ultrasonography compared with endometrial biopsy for the detection of endometrial disease. Postmenopausal Estrogen/Progestin Interventions Trial. ( 9400035 )
1997
26
Combination of vaginal ultrasonography and pipelle sampling in the diagnosis of endometrial disease. ( 8775255 )
1996
27
Endopap-versus Pipelle-sampling in the diagnosis of postmenopausal endometrial disease. ( 8801158 )
1996
28
Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women. ( 7617370 )
1995
29
Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women. ( 7862370 )
1995
30
Vaginal ultrasonography in the diagnosis of postmenopausal endometrial disease. ( 7809789 )
1994
31
The effect of age and parity on the development of equine chronic endometrial disease. ( 1884699 )
1991
32
Effect of progesterone administration on rat endometrial disease after exposure to N-nitrosomethylurea. ( 6891937 )
1982
33
Endometrial disease after treatment with oestrogens and progestogens in the climacteric. ( 7370682 )
1980
34
Prevention and treatment of endometrial disease in climacteric women receiving oestrogen therapy. ( 89511 )
1979
35
Vacuum aspiration: an efficient outpatient screening technic for endometrial disease. ( 850801 )
1977

Variations for Endometrial Disease

Expression for Endometrial Disease

Search GEO for disease gene expression data for Endometrial Disease.

Pathways for Endometrial Disease

Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 CXCL8 IL1B IL6 PGF TLR4 TNF
2
Show member pathways
13.02 CXCL8 IL1B IL6 PTGS2 TLR4 TNF
3
Show member pathways
12.97 CXCL8 IL1B IL6 TLR4 TNF
4
Show member pathways
12.95 IL6 PGF PTGS2 TLR4 TNF
5 12.82 CXCL8 ESR1 IL6 PGF PTGS2
6
Show member pathways
12.78 CXCL8 IL1B IL6 TLR4 TNF
7
Show member pathways
12.73 CXCL8 IL1B IL6 NLRC5 TLR4 TNF
8
Show member pathways
12.68 IL1B IL6 PGF TLR4 TNF
9
Show member pathways
12.56 IL1B IL6 TLR4 TNF
10
Show member pathways
12.33 IL1B IL6 PTGS2 TNF
11
Show member pathways
12.31 CXCL8 IL1B IL6 PTGS2 TNF
12
Show member pathways
12.27 CXCL8 IL6 TLR4 TNF
13
Show member pathways
12.27 CXCL8 IL1B IL6 PTGS2 TLR4 TNF
14
Show member pathways
12.26 IL1B PTGS2 TLR4 TNF
15
Show member pathways
12.25 CXCL8 IL1B IL6 PGF TNF
16 12.22 IL1B IL6 TLR4 TNF
17
Show member pathways
12.2 IL1B IL6 PTGS2 TNF
18
Show member pathways
12.2 CXCL8 IL1B IL6 PTGS2 TNF
19 12.17 IL6 PTGS2 TLR4 TNF
20 12.16 CXCL8 IL1B IL6 TNF
21
Show member pathways
12.16 CXCL8 IL1B IL6 TLR4 TNF
22
Show member pathways
12.04 CXCL8 IL1B IL6 PGF
23
Show member pathways
12.04 IL1B IL6 TLR4 TNF
24
Show member pathways
12.02 IL1B IL6 TLR4 TNF
25 11.97 CXCL8 IL1B IL6 PTGS2 TNF
26 11.95 IL1B IL6 PTGS2 TNF
27 11.92 CXCL8 IL1B IL6
28 11.9 CXCL8 IL1B IL6 TNF
29 11.87 IL1B IL6 TNF
30 11.86 CXCL8 IL1B IL6 TLR4 TNF
31
Show member pathways
11.85 CXCL8 IL6 TLR4
32 11.83 CXCL8 IL1B IL6 TLR4
33 11.83 CXCL8 IL1B PTGS2 TLR4 TNF
34 11.79 CXCL8 IL1B IL6 TLR4 TNF
35
Show member pathways
11.76 CXCL8 PTGS2 TNF
36 11.75 IL1B IL6 TNF
37 11.73 IL1B IL6 PTGS2 TNF
38 11.68 CXCL8 IL1B IL6 TLR4 TNF
39 11.67 CXCL8 IL1B IL6 TNF
40 11.57 CXCL8 IL6 PTGS2
41 11.54 HP IL6 TNF
42 11.54 ESR1 PTGS2 TNF
43 11.53 IL1B TLR4 TNF
44
Show member pathways
11.52 CXCL8 IL1B IL6 PTGS2 TNF
45 11.49 CYP19A1 IL1B IL6 TNF
46 11.4 CXCL8 IL1B IL6 TLR4 TNF
47 11.37 IL1B IL6 TNF
48 11.37 IL1B IL6 TLR4 TNF
49 11.32 IL1B IL6 TNF
50 11.3 IL1B IL6 TNF

GO Terms for Endometrial Disease

Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 HP IL1B IL6 OXT PGF
2 extracellular region GO:0005576 9.23 CXCL8 DSPP HP IL1B IL6 OXT

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.93 CXCL8 IL1B IL6 PTGS2 TNF
2 regulation of signaling receptor activity GO:0010469 9.93 CXCL8 IL1B IL6 OXT PGF TNF
3 defense response GO:0006952 9.89 CXCL8 HP TNF
4 response to organic cyclic compound GO:0014070 9.88 IL1B OXT PTGS2
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 TLR4 TNF
6 activation of MAPK activity GO:0000187 9.87 IL1B TLR4 TNF
7 response to organic substance GO:0010033 9.85 HP PTGS2 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 ESR1 IL1B IL6 TNF
9 inflammatory response GO:0006954 9.85 CXCL8 IL1B IL6 PTGS2 TLR4 TNF
10 positive regulation of JNK cascade GO:0046330 9.84 IL1B TLR4 TNF
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 IL6 PTGS2 TNF
12 cellular response to mechanical stimulus GO:0071260 9.83 IL1B PTGS2 TLR4
13 memory GO:0007613 9.82 IL1B OXT PTGS2
14 response to estradiol GO:0032355 9.81 ESR1 IL1B OXT PTGS2
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 IL6 PTGS2 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.79 IL1B TLR4 TNF
17 positive regulation of interferon-gamma production GO:0032729 9.77 IL1B TLR4 TNF
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 IL1B TLR4 TNF
19 positive regulation of interleukin-8 production GO:0032757 9.73 IL1B TLR4 TNF
20 regulation of inflammatory response GO:0050727 9.73 ESR1 PTGS2 TLR4 TNF
21 cellular response to lipopolysaccharide GO:0071222 9.72 CXCL8 IL1B IL6 TLR4 TNF
22 positive regulation of synaptic transmission GO:0050806 9.71 OXT TNF
23 response to vitamin D GO:0033280 9.71 IL1B PTGS2
24 positive regulation of interleukin-6 production GO:0032755 9.71 IL1B IL6 TLR4 TNF
25 embryonic digestive tract development GO:0048566 9.7 CXCL8 TNF
26 uterus development GO:0060065 9.7 CYP19A1 ESR1
27 androgen metabolic process GO:0008209 9.7 CYP19A1 ESR1
28 negative regulation of lipid catabolic process GO:0050995 9.7 IL1B TNF
29 negative regulation of neurogenesis GO:0050768 9.7 IL1B IL6 TNF
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.69 IL1B TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
33 induction of positive chemotaxis GO:0050930 9.68 CXCL8 PGF
34 response to carbohydrate GO:0009743 9.68 DSPP IL1B
35 ovulation GO:0030728 9.68 IL1B PTGS2
36 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
37 positive regulation of chemokine production GO:0032722 9.67 IL6 TLR4 TNF
38 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
39 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B IL6 TNF
40 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
41 positive regulation of prostaglandin secretion GO:0032308 9.64 IL1B OXT
42 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
43 chronic inflammatory response to antigenic stimulus GO:0002439 9.61 IL1B TNF
44 sequestering of triglyceride GO:0030730 9.61 IL1B TNF
45 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 IL1B TNF
46 positive regulation of estradiol secretion GO:2000866 9.58 CYP19A1 IL1B
47 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 IL1B PTGS2 TLR4 TNF
48 positive regulation of neuroinflammatory response GO:0150078 9.33 IL1B IL6 TNF
49 positive regulation of fever generation GO:0031622 9.13 IL1B PTGS2 TNF
50 response to glucocorticoid GO:0051384 9.02 IL1B IL6 OXT PTGS2 TNF

Molecular functions related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL8 IL1B IL6 TNF

Sources for Endometrial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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