MCID: END080
MIFTS: 43

Endometrial Disease

Categories: Reproductive diseases

Aliases & Classifications for Endometrial Disease

MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 15
Endometrial Disorder 55 73
Endometrial Diseases 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1005
NCIt 50 C3504
SNOMED-CT 68 418632009

Summaries for Endometrial Disease

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to peritonitis and endometriosis. An important gene associated with Endometrial Disease is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Pathways in cancer and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. The drugs Bupivacaine and Mepivacaine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and skeletal muscle, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Endometrial Disease

Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 peritonitis 29.3 CXCL8 IL1B IL6
2 endometriosis 29.1 CXCL8 CYP19A1 ESR1 IL6
3 progesterone-receptor positive breast cancer 10.8 CYP19A1 ESR1
4 gender identity disorder 10.8 CYP19A1 ESR1
5 estrogen excess 10.7 CYP19A1 ESR1
6 vulvar vestibulitis syndrome 10.7 ESR1 IL1B
7 mammographic density 10.7 CYP19A1 ESR1
8 prosthetic joint infection 10.6 IL1B TLR4
9 peptic esophagitis 10.6 CXCL8 IL1B
10 pouchitis 10.6 CXCL8 TLR4
11 haemophilus influenzae 10.6 CXCL8 IL1B
12 opisthorchiasis 10.5 CXCL8 IL1B
13 campylobacteriosis 10.5 IL1B TLR4
14 dental fluorosis 10.5 DSPP ESR1
15 endometrial stromal sarcoma 10.5 CXCL8 CYP19A1 ESR1
16 suppurative otitis media 10.5 IL1B TLR4
17 osteoporotic fracture 10.4 ESR1 IL6
18 vaginal discharge 10.4 DSPP HP PGF
19 acute generalized exanthematous pustulosis 10.4 CXCL8 PTGS2
20 leukoregulin 10.4 CXCL8 PTGS2
21 crohn's colitis 10.4 CXCL8 IL1B
22 cervical incompetence 10.3 IL6 SERPINH1
23 periodontitis, chronic 10.3 IL1B IL6
24 acute endometritis 10.3 NLRC5 PTGS2
25 middle ear disease 10.3 CXCL8 IL1B TLR4
26 ductal carcinoma in situ 10.3 CYP19A1 ESR1 PTGS2
27 lymphadenitis 10.3 CXCL8 IL1B TLR4
28 adenomyosis 10.3 ESR1 PTGS2
29 acute transverse myelitis 10.3 CXCL8 IL6
30 streptococcal toxic-shock syndrome 10.3 CXCL8 IL6
31 dental pulp disease 10.3 CXCL8 DSPP IL1B
32 helicobacter pylori infection 10.3 CXCL8 IL1B TLR4
33 uremic pruritus 10.3 IL1B IL6
34 glossitis 10.3 IL1B IL6
35 denture stomatitis 10.3 CXCL8 IL6
36 euthyroid sick syndrome 10.2 IL1B IL6
37 laryngitis 10.2 IL1B IL6
38 papillary conjunctivitis 10.2 CXCL8 IL6
39 visceral leishmaniasis 10.2 CXCL8 IL1B TLR4
40 spondylolisthesis 10.2 ESR1 PTGS2
41 ascaris lumbricoides infection 10.2 IL1B IL6
42 postmenopausal atrophic vaginitis 10.2 ESR1 OXT
43 pharyngitis 10.1 CXCL8 IL1B PTGS2
44 acute vascular insufficiency of intestine 10.1 IL1B IL6
45 gastric ulcer 10.1 CXCL8 IL1B PTGS2
46 peptic ulcer disease 10.1 CXCL8 IL1B PTGS2
47 stomach disease 10.1 CXCL8 IL1B PTGS2
48 poems syndrome 10.1 IL1B IL6
49 acute monoblastic leukemia 10.1 CXCL8 IL6
50 gastroesophageal reflux 10.1 CXCL8 IL1B PTGS2

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease

Symptoms & Phenotypes for Endometrial Disease

MGI Mouse Phenotypes related to Endometrial Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 IL1B CYP19A1 IL6 ESR1 OXT HP
2 growth/size/body region MP:0005378 10.09 PGF IL1B CYP19A1 IL6 ESR1 OXT
3 immune system MP:0005387 10.06 HP PGF IL1B CYP19A1 IL6 NLRC5
4 adipose tissue MP:0005375 10.04 PGF CYP19A1 IL6 ESR1 OXT PTGS2
5 digestive/alimentary MP:0005381 10 CYP19A1 IL6 ESR1 OXT PTGS2 SERPINH1
6 integument MP:0010771 9.97 PGF IL1B CYP19A1 IL6 ESR1 OXT
7 liver/biliary system MP:0005370 9.8 HP CYP19A1 IL6 ESR1 TLR4 PTGS2
8 neoplasm MP:0002006 9.8 PGF IL1B IL6 ESR1 HP PTGS2
9 renal/urinary system MP:0005367 9.7 HP CYP19A1 IL6 ESR1 OXT PTGS2
10 respiratory system MP:0005388 9.43 PGF IL6 ESR1 TLR4 PTGS2 SERPINH1
11 skeleton MP:0005390 9.17 IL1B CYP19A1 IL6 ESR1 TLR4 PTGS2

Drugs & Therapeutics for Endometrial Disease

Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5 Central Nervous System Depressants Phase 4
6 Peripheral Nervous System Agents Phase 4
7 Pharmaceutical Solutions Phase 4
8
Misoprostol Approved Phase 3 59122-46-2 5282381
9
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
10
Tamoxifen Approved Phase 3 10540-29-1 2733526
11
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
12 Antacids Phase 3
13 Anti-Ulcer Agents Phase 3
14 Gastrointestinal Agents Phase 3
15 Oxytocics Phase 3
16 Antineoplastic Agents, Hormonal Phase 3
17 Bone Density Conservation Agents Phase 3
18 Contraceptive Agents Phase 3
19 Contraceptive Agents, Male Phase 3
20 Contraceptives, Oral Phase 3
21 Estrogen Antagonists Phase 3
22 Estrogen Receptor Modulators Phase 3
23 Estrogens Phase 3
24 Hormone Antagonists Phase 3
25 Hormones Phase 3
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
27
Medroxyprogesterone Phase 3 520-85-4 10631
28 Selective Estrogen Receptor Modulators Phase 3
29 Citrate Nutraceutical Phase 3
30
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
31
Lenograstim Approved, Investigational Phase 2 135968-09-1
32
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
33 Adjuvants, Immunologic Phase 2
34 Albumin-Bound Paclitaxel Phase 2
35 Antimitotic Agents Phase 2
36 Antineoplastic Agents, Phytogenic Phase 2
37 Epoetin alfa 113427-24-0
38 Hematinics

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Role of Intrauterine Cornual Block in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 Misoprostol Administration Before Operative Hysteroscopy Completed NCT01805115 Phase 3 Oral misoprostol;Sublingual misoprostol;Vaginal misoprostol;Control
3 S9630, Medroxyprogesterone in Treating Women With Breast Cancer Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
4 Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness Recruiting NCT03067623 Phase 2 PRP
5 Weekly Paclitaxel/Carboplatin With Neupogen in Gynaecological Cancers Active, not recruiting NCT01523678 Phase 2 Filgrastim;Paclitaxel;Carboplatin
6 A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer Withdrawn NCT02127151 Phase 2 BMN 673
7 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Unknown status NCT02691715 Not Applicable
8 REM (Risk Of Endometrial Malignancy) Completed NCT01830192 Not Applicable
9 Proliferative Effects of Erythropoietin on Human Endometrium Completed NCT03060603 Erythropoietin
10 Fast Versus Slow Tenaculum Placement Completed NCT02716636 Not Applicable
11 Efficacy and Tolerability Study of ZP-025 Vaginal Gel for the Treatment of Vaginal Dryness Completed NCT02994342 Not Applicable
12 4 (HE4) in Benign Endometrial Disease and Endometrial Cancer Recruiting NCT03459976
13 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Recruiting NCT03289468
14 Intrauterine Microbiota During IVF in Patients Affected With Isthmocele. Recruiting NCT03519763
15 Human Epididymis Protein 4 in Endometrial Carcinoma Recruiting NCT03456791
16 Can the iKnife Distinguish Between Normal and Malignant Endometrial Tissue? Recruiting NCT03207074 Not Applicable
17 Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss Recruiting NCT03027479 Not Applicable
18 Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Recruiting NCT03351673 Not Applicable

Search NIH Clinical Center for Endometrial Disease

Genetic Tests for Endometrial Disease

Anatomical Context for Endometrial Disease

MalaCards organs/tissues related to Endometrial Disease:

41
Breast, Bone, Skeletal Muscle, Ovary, Colon

Publications for Endometrial Disease

Articles related to Endometrial Disease:

(show all 24)
# Title Authors Year
1
Tissue and circulating microRNA influence reproductive function in endometrial disease. ( 24055529 )
2013
2
CyclinD1, a prominent prognostic marker for endometrial diseases. ( 23947899 )
2013
3
Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. ( 22384417 )
2011
4
Progesterone resistance and endometrial disease. Preface. ( 20104423 )
2010
5
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. ( 19439667 )
2009
6
Performance of office hysteroscopy and endometrial biopsy for detecting endometrial disease in women at risk of human non-polyposis colon cancer: a prospective study. ( 18217965 )
2008
7
Endometrial disorders in patients with peritoneal serous papillary carcinoma. ( 16860923 )
2007
8
The role of Pipelle Mark II sampling in endometrial disease diagnosis. ( 17029754 )
2007
9
Reproducibility of endometrial vascular patterns in endometrial disease as assessed by transvaginal power Doppler sonography in women with postmenopausal bleeding. ( 16439778 )
2006
10
Clinical inquiries. Can transvaginal ultrasound detect endometrial disease among asymptomatic postmenopausal patients? ( 15581447 )
2004
11
Is pipelle biopsy really adequate for diagnosing endometrial disease? ( 15173672 )
2004
12
Outpatient hysteroscopy and ultrasonography in the management of endometrial disease. ( 15232484 )
2004
13
Endometrial disorders in 406 breast cancer patients on tamoxifen: the case for less intensive monitoring. ( 11803101 )
2002
14
Evaluation of outpatient hysteroscopy and ultrasonography in the diagnosis of endometrial disease. ( 12052590 )
2002
15
Transvaginal uterine ultrasonography compared with endometrial biopsy for the detection of endometrial disease in perimenopausal women with uterine bleeding. ( 12168877 )
2002
16
Diagnosis of premalignant endometrial disease. ( 11986334 )
2002
17
An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. ( 11174482 )
2001
18
Role of aromatase in endometrial disease. ( 11850203 )
2001
19
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11354070 )
2001
20
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11084170 )
2000
21
Is endometriosis an endometrial disease? ( 10869783 )
2000
22
Assessment of hypermethylated DNA in two promoter regions of the estrogen receptor alpha gene in human endometrial diseases. ( 10620447 )
2000
23
Endometrial disease diagnosed by transvaginal ultrasound and dilatation and curettage. ( 10326888 )
1999
24
Endometrial thickness in tamoxifen-treated patients: an independent predictor of endometrial disease. ( 10362171 )
1999

Variations for Endometrial Disease

Expression for Endometrial Disease

Search GEO for disease gene expression data for Endometrial Disease.

Pathways for Endometrial Disease

Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1 12.73 CXCL8 ESR1 IL6 PGF PTGS2
2
Show member pathways
12.65 CXCL8 IL1B IL6 NLRC5 TLR4
3
Show member pathways
12.57 IL1B IL6 PGF TLR4
4
Show member pathways
12.45 CXCL8 IL6 PTGS2 TLR4
5
Show member pathways
12.23 CXCL8 IL1B IL6 PTGS2
6
Show member pathways
12.11 CXCL8 IL1B IL6 PTGS2
7
Show member pathways
12.07 CXCL8 IL1B IL6 TLR4
8
Show member pathways
12.02 CXCL8 IL1B IL6 PTGS2 TLR4
9
Show member pathways
11.96 CXCL8 IL1B IL6 PGF
10 11.88 CXCL8 IL1B IL6 PTGS2
11 11.85 IL1B IL6 PTGS2
12 11.83 CXCL8 IL1B IL6
13 11.79 CXCL8 IL1B IL6
14 11.79 CXCL8 IL1B IL6 TLR4
15 11.77 CXCL8 IL1B PTGS2 TLR4
16
Show member pathways
11.76 CXCL8 IL6 TLR4
17 11.73 CXCL8 IL1B IL6 TLR4
18 11.67 CXCL8 IL1B IL6 TLR4
19 11.59 CXCL8 IL1B IL6 TLR4
20 11.58 CXCL8 IL1B IL6
21 11.47 CXCL8 IL6 PTGS2
22
Show member pathways
11.47 CXCL8 IL1B IL6 PTGS2
23 11.39 CYP19A1 IL1B IL6
24 11.3 CXCL8 IL1B IL6 TLR4
25 11.26 IL1B IL6 TLR4
26 11.15 CXCL8 IL1B IL6 PTGS2
27 11.1 CXCL8 IL1B IL6 PTGS2 TLR4
28 10.95 CXCL8 IL1B IL6 TLR4
29 10.91 CXCL8 IL6 PTGS2
30 10.18 CYP19A1 ESR1

GO Terms for Endometrial Disease

Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CXCL8 HP IL1B IL6 OXT PGF

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.9 CXCL8 IL1B IL6 PTGS2
2 cytokine-mediated signaling pathway GO:0019221 9.81 CXCL8 IL1B IL6 PTGS2
3 positive regulation of angiogenesis GO:0045766 9.77 CXCL8 IL1B PGF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.76 IL1B IL6 TLR4
5 cellular response to lipopolysaccharide GO:0071222 9.75 CXCL8 IL6 TLR4
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.71 ESR1 IL1B IL6
7 response to estradiol GO:0032355 9.67 ESR1 OXT PTGS2
8 regulation of inflammatory response GO:0050727 9.65 ESR1 PTGS2 TLR4
9 regulation of signaling receptor activity GO:0010469 9.65 CXCL8 IL1B IL6 OXT PGF
10 cellular response to mechanical stimulus GO:0071260 9.63 IL1B PTGS2 TLR4
11 response to lipopolysaccharide GO:0032496 9.62 CXCL8 IL1B PTGS2 TLR4
12 positive regulation of leukocyte chemotaxis GO:0002690 9.61 CXCL8 IL6
13 response to glucocorticoid GO:0051384 9.58 IL6 OXT PTGS2
14 positive regulation of chemokine production GO:0032722 9.57 IL6 TLR4
15 androgen metabolic process GO:0008209 9.56 CYP19A1 ESR1
16 uterus development GO:0060065 9.55 CYP19A1 ESR1
17 induction of positive chemotaxis GO:0050930 9.52 CXCL8 PGF
18 positive regulation of prostaglandin secretion GO:0032308 9.43 IL1B OXT
19 positive regulation of fever generation GO:0031622 9.37 IL1B PTGS2
20 inflammatory response GO:0006954 9.35 CXCL8 IL1B IL6 PTGS2 TLR4
21 positive regulation of interleukin-6 production GO:0032755 9.33 IL1B IL6 TLR4
22 positive regulation of nitric oxide biosynthetic process GO:0045429 8.8 IL1B PTGS2 TLR4

Sources for Endometrial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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