MCID: END080
MIFTS: 49

Endometrial Disease

Categories: Reproductive diseases

Aliases & Classifications for Endometrial Disease

MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 15
Endometrial Disorder 56 74
Endometrial Diseases 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1005
NCIt 51 C3504

Summaries for Endometrial Disease

Disease Ontology : 12 A uterine disease that is located in the endometrium.

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to endometritis and endometriosis. An important gene associated with Endometrial Disease is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Mepivacaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, ovary and skeletal muscle, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Endometrial Disease

Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 257)
# Related Disease Score Top Affiliating Genes
1 endometritis 30.2 ESR1 HP IL1B IL6 OXT PGF
2 endometriosis 28.8 CXCL8 CYP19A1 ESR1 IL1B IL6 PTGS2
3 tamoxifen-related endometrial lesion 10.9
4 progesterone-receptor positive breast cancer 10.5 CYP19A1 ESR1
5 gender identity disorder 10.5 CYP19A1 ESR1
6 estrogen excess 10.5 CYP19A1 ESR1
7 campylobacteriosis 10.4 IL1B TLR4
8 peptic esophagitis 10.4 CXCL8 IL1B
9 pouchitis 10.4 CXCL8 TLR4
10 osteoporotic fracture 10.4 ESR1 IL6
11 acute cervicitis 10.4 TLR2 TLR4
12 fungal keratitis 10.4 TLR2 TLR4
13 mycobacterium kansasii 10.4 CXCL8 TLR2
14 mycobacterium marinum 10.4 CXCL8 TLR2
15 neurosyphilis 10.4 CXCL8 TLR2
16 uremic pruritus 10.4 IL1B IL6
17 postmenopausal atrophic vaginitis 10.3 ESR1 OXT
18 anterior uveitis 10.3 IL6 TLR4
19 denture stomatitis 10.3 CXCL8 IL6
20 papillary conjunctivitis 10.3 CXCL8 IL6
21 acute transverse myelitis 10.3 CXCL8 IL6
22 alcoholic gastritis 10.3 IL1B PTGS2
23 leukoregulin 10.3 CXCL8 PTGS2
24 acute generalized exanthematous pustulosis 10.3 CXCL8 PTGS2
25 melancholia 10.3 HP TNF
26 kashin-beck disease 10.3 IL1B TNF
27 burns 10.3 IL1B TNF
28 cerebral artery occlusion 10.3 IL1B TNF
29 staphylococcal toxic shock syndrome 10.3 IL1B TNF
30 tungiasis 10.2 CXCL8 TNF
31 cardiac sarcoidosis 10.2 CXCL8 TNF
32 vaginal discharge 10.2 DSPP HP PGF
33 hellp syndrome 10.2 HP IL6 PGF
34 retinitis pigmentosa 55 10.2 IL6 TNF
35 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
36 critical limb ischemia 10.2 IL6 TNF
37 juvenile ankylosing spondylitis 10.2 IL6 TNF
38 prosthetic joint infection 10.2 IL1B TLR2 TLR4
39 autoimmune myocarditis 10.2 IL6 TNF
40 null-cell leukemia 10.2 IL6 TNF
41 leukomalacia 10.2 IL6 TNF
42 cardiogenic shock 10.2 IL6 TNF
43 mycobacterium chelonae 10.2 CXCL8 TLR2
44 ovarian disease 10.2 CYP19A1 ESR1 TNF
45 suppurative otitis media 10.1 IL1B TLR2 TLR4
46 breast disease 10.1 CYP19A1 ESR1 TNF
47 recurrent corneal erosion 10.1 CXCL8 IL1B IL6
48 bagassosis 10.1 CXCL8 IL1B IL6
49 gastroesophageal reflux 10.1 CXCL8 IL1B PTGS2
50 funisitis 10.1 CXCL8 IL1B IL6

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease

Symptoms & Phenotypes for Endometrial Disease

MGI Mouse Phenotypes related to Endometrial Disease:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.28 CYP19A1 ESR1 HP IL1B IL6 OXT
2 homeostasis/metabolism MP:0005376 10.22 CYP19A1 ESR1 HP IL1B IL6 OXT
3 growth/size/body region MP:0005378 10.21 CYP19A1 ESR1 IL1B IL6 OXT PGF
4 adipose tissue MP:0005375 10.2 CYP19A1 ESR1 IL6 OXT PGF PTGS2
5 immune system MP:0005387 10.2 CYP19A1 ESR1 HP IL1B IL6 NLRC5
6 hematopoietic system MP:0005397 10.19 CYP19A1 ESR1 HP IL1B IL6 NLRC5
7 digestive/alimentary MP:0005381 10.13 CYP19A1 ESR1 IL6 OXT PTGS2 TLR2
8 integument MP:0010771 10.13 CYP19A1 ESR1 IL1B IL6 OXT PGF
9 liver/biliary system MP:0005370 10.01 CYP19A1 ESR1 HP IL6 PTGS2 TLR2
10 neoplasm MP:0002006 9.97 ESR1 HP IL1B IL6 PGF PTGS2
11 muscle MP:0005369 9.91 CYP19A1 ESR1 IL6 PTGS2 TLR2 TLR4
12 nervous system MP:0003631 9.91 CYP19A1 ESR1 IL1B IL6 OXT PTGS2
13 renal/urinary system MP:0005367 9.76 CYP19A1 ESR1 HP IL6 OXT PTGS2
14 respiratory system MP:0005388 9.5 ESR1 IL6 PGF PTGS2 TLR2 TLR4
15 skeleton MP:0005390 9.23 CYP19A1 ESR1 IL1B IL6 PTGS2 TLR2

Drugs & Therapeutics for Endometrial Disease

Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
3
tannic acid Approved Phase 4 1401-55-4
4
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
5 Pharmaceutical Solutions Phase 4
6 Central Nervous System Depressants Phase 4
7 Peripheral Nervous System Agents Phase 4
8 Anesthetics, Local Phase 4
9 Anesthetics Phase 4
10 Hormones Phase 4,Phase 3
11 Follicle Stimulating Hormone Phase 4
12
Misoprostol Approved Phase 3 59122-46-2 5282381
13
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
14
Sodium Citrate Approved, Investigational Phase 3 68-04-2
15
Tamoxifen Approved Phase 3 10540-29-1 2733526
16
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
17 Oxytocics Phase 3
18 Anti-Ulcer Agents Phase 3
19 Gastrointestinal Agents Phase 3
20 Antacids Phase 3
21 Estrogen Receptor Antagonists Phase 3
22 Antineoplastic Agents, Hormonal Phase 3
23 Selective Estrogen Receptor Modulators Phase 3
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
25 Estrogen Receptor Modulators Phase 3
26 Citrate Phase 3
27 Contraceptive Agents Phase 3
28 Bone Density Conservation Agents Phase 3
29 Hormone Antagonists Phase 3
30
Medroxyprogesterone Phase 3 520-85-4 10631
31 Estrogens Phase 3
32 Contraceptives, Oral Phase 3
33 Estrogen Antagonists Phase 3
34 Contraceptive Agents, Male Phase 3
35
Lenograstim Approved, Investigational Phase 2 135968-09-1
36
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
37
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
38 Immunologic Factors Phase 2
39 Albumin-Bound Paclitaxel Phase 2
40 Antineoplastic Agents, Phytogenic Phase 2
41 Adjuvants, Immunologic Phase 2
42 Antimitotic Agents Phase 2
43
Progesterone Approved, Vet_approved 57-83-0 5994
44
protease inhibitors
45 HIV Protease Inhibitors
46 Hematinics
47 Epoetin alfa 113427-24-0
48 Progestins

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Role of Intrauterine Cornual Block in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity Not yet recruiting NCT03755973 Phase 4 CFA;rFSH
3 Misoprostol Administration Before Operative Hysteroscopy Completed NCT01805115 Phase 3 Oral misoprostol;Sublingual misoprostol;Vaginal misoprostol;Control
4 S9630, Medroxyprogesterone in Treating Women With Breast Cancer Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
5 Autologous Platelet-Rich Plasma (PRP) and Endometrial Thickness Recruiting NCT03067623 Phase 2 PRP
6 Weekly Paclitaxel/Carboplatin With Neupogen in Gynaecological Cancers Active, not recruiting NCT01523678 Phase 2 Filgrastim;Paclitaxel;Carboplatin
7 A Parp Inhibitor (BMN 673) for Inoperable Advanced eNDometrial cAncer Withdrawn NCT02127151 Phase 2 BMN 673
8 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Unknown status NCT02691715 Not Applicable
9 REM (Risk Of Endometrial Malignancy) Completed NCT01830192 Not Applicable
10 Human Epididymis Protein 4 in Endometrial Carcinoma Completed NCT03456791
11 Proliferative Effects of Erythropoietin on Human Endometrium Completed NCT03060603 Erythropoietin
12 Fast Versus Slow Tenaculum Placement Completed NCT02716636 Not Applicable
13 Efficacy and Tolerability Study of ZP-025 Vaginal Gel for the Treatment of Vaginal Dryness Completed NCT02994342 Not Applicable
14 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Recruiting NCT03289468
15 Intrauterine Microbiota During IVF in Patients Affected With Isthmocele. Recruiting NCT03519763
16 HE4 is a Beneficial Biomarker in Endometrial Cancer Recruiting NCT03459976
17 Endometrial Injury In Recurrent Implantation Failure Recruiting NCT03748238 Not Applicable
18 Can the iKnife Distinguish Between Normal and Malignant Endometrial Tissue? Recruiting NCT03207074 Not Applicable
19 Skeletal Muscle Energy Metabolism in Women With Weight Loss and Ovarian and/or Endometrial Cancer With Weight Loss Recruiting NCT03027479 Not Applicable
20 Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Recruiting NCT03351673 Not Applicable
21 Cancer Driving Mutations in Endometriosis Lesions and Development of Progesterone Resistance Not yet recruiting NCT03756480

Search NIH Clinical Center for Endometrial Disease

Genetic Tests for Endometrial Disease

Anatomical Context for Endometrial Disease

MalaCards organs/tissues related to Endometrial Disease:

42
Bone, Ovary, Skeletal Muscle, Colon, Heart, Lymph Node, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Disease:

20
The Endometrium

Publications for Endometrial Disease

Articles related to Endometrial Disease:

(show all 35)
# Title Authors Year
1
Tissue and circulating microRNA influence reproductive function in endometrial disease. ( 24055529 )
2013
2
Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. ( 22384417 )
2011
3
Progesterone resistance and endometrial disease. Preface. ( 20104423 )
2010
4
Genome-based expression profiling as a single standardized microarray platform for the diagnosis of endometrial disorder: an array of 126-gene model. ( 19328470 )
2010
5
Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. ( 19439667 )
2009
6
Performance of office hysteroscopy and endometrial biopsy for detecting endometrial disease in women at risk of human non-polyposis colon cancer: a prospective study. ( 18217965 )
2008
7
The role of Pipelle Mark II sampling in endometrial disease diagnosis. ( 17029754 )
2007
8
Reproducibility of endometrial vascular patterns in endometrial disease as assessed by transvaginal power Doppler sonography in women with postmenopausal bleeding. ( 16439778 )
2006
9
Clinical inquiries. Can transvaginal ultrasound detect endometrial disease among asymptomatic postmenopausal patients? ( 15581447 )
2004
10
Outpatient hysteroscopy and ultrasonography in the management of endometrial disease. ( 15232484 )
2004
11
Is pipelle biopsy really adequate for diagnosing endometrial disease? ( 15173672 )
2004
12
Transvaginal uterine ultrasonography compared with endometrial biopsy for the detection of endometrial disease in perimenopausal women with uterine bleeding. ( 12168877 )
2002
13
Diagnosis of premalignant endometrial disease. ( 11986334 )
2002
14
Evaluation of outpatient hysteroscopy and ultrasonography in the diagnosis of endometrial disease. ( 12052590 )
2002
15
An assessment of the value of ultrasonographic screening for endometrial disease in postmenopausal women without symptoms. ( 11174482 )
2001
16
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11354070 )
2001
17
Role of aromatase in endometrial disease. ( 11850203 )
2001
18
Is endometriosis an endometrial disease? ( 10869783 )
2000
19
Normal endometrial cells in Papanicolaou smears: prevalence in women with and without endometrial disease. ( 11084170 )
2000
20
Prediction of benign and malignant endometrial disease: hysterosonographic-pathologic correlation. ( 10207420 )
1999
21
Ultrasonographic evaluation of endometrial disease in postmenopausal patients with breast cancer and tamoxifen treatment. ( 9914614 )
1999
22
Endometrial disease diagnosed by transvaginal ultrasound and dilatation and curettage. ( 10326888 )
1999
23
Endometrial thickness in tamoxifen-treated patients: an independent predictor of endometrial disease. ( 10362171 )
1999
24
Cervical cytology in menopausal women at high risk for endometrial disease. ( 9818777 )
1998
25
Transvaginal ultrasonography compared with endometrial biopsy for the detection of endometrial disease. Postmenopausal Estrogen/Progestin Interventions Trial. ( 9400035 )
1997
26
Endopap-versus Pipelle-sampling in the diagnosis of postmenopausal endometrial disease. ( 8801158 )
1996
27
Combination of vaginal ultrasonography and pipelle sampling in the diagnosis of endometrial disease. ( 8775255 )
1996
28
Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women. ( 7617370 )
1995
29
Combining vaginal ultrasonography and office endometrial sampling in the diagnosis of endometrial disease in postmenopausal women. ( 7862370 )
1995
30
Vaginal ultrasonography in the diagnosis of postmenopausal endometrial disease. ( 7809789 )
1994
31
The effect of age and parity on the development of equine chronic endometrial disease. ( 1884699 )
1991
32
Effect of progesterone administration on rat endometrial disease after exposure to N-nitrosomethylurea. ( 6891937 )
1982
33
Endometrial disease after treatment with oestrogens and progestogens in the climacteric. ( 7370682 )
1980
34
Prevention and treatment of endometrial disease in climacteric women receiving oestrogen therapy. ( 89511 )
1979
35
Vacuum aspiration: an efficient outpatient screening technic for endometrial disease. ( 850801 )
1977

Variations for Endometrial Disease

Expression for Endometrial Disease

Search GEO for disease gene expression data for Endometrial Disease.

Pathways for Endometrial Disease

Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 CXCL8 HP IL1B IL6 NLRC5 PTGS2
2
Show member pathways
13.4 CXCL8 IL1B IL6 PGF TLR2 TLR4
3
Show member pathways
13.09 CXCL8 IL1B IL6 TLR2 TLR4 TNF
4
Show member pathways
12.99 IL6 PGF PTGS2 TLR2 TLR4 TNF
5
Show member pathways
12.98 CXCL8 IL1B IL6 PTGS2 TLR2 TLR4
6 12.83 CXCL8 ESR1 IL6 PGF PTGS2
7
Show member pathways
12.78 CXCL8 IL1B IL6 NLRC5 TLR4 TNF
8
Show member pathways
12.73 IL1B IL6 PGF TLR2 TLR4 TNF
9
Show member pathways
12.63 IL1B PGF TLR2 TLR4 TNF
10
Show member pathways
12.61 IL1B IL6 TLR2 TLR4 TNF
11 12.54 IL1B PTGS2 TLR2 TNF
12
Show member pathways
12.34 IL1B IL6 PTGS2 TNF
13
Show member pathways
12.32 CXCL8 IL1B IL6 PTGS2 TLR2 TNF
14 12.31 ESR1 TLR2 TLR4 TNF
15
Show member pathways
12.31 CXCL8 IL1B IL6 PTGS2 TLR4 TNF
16
Show member pathways
12.3 CXCL8 IL6 TLR2 TLR4 TNF
17
Show member pathways
12.29 IL1B PTGS2 TLR2 TLR4 TNF
18
Show member pathways
12.28 CXCL8 IL1B IL6 PGF TNF
19 12.26 IL1B IL6 TLR2 TLR4 TNF
20
Show member pathways
12.23 IL1B IL6 PTGS2 TNF
21 12.21 IL6 PTGS2 TLR2 TLR4 TNF
22 12.2 CXCL8 IL1B IL6 TNF
23
Show member pathways
12.18 CXCL8 IL1B IL6 PTGS2 TLR2 TNF
24
Show member pathways
12.13 CXCL8 IL1B IL6 TLR2 TLR4 TNF
25
Show member pathways
12.09 IL1B IL6 TLR2 TLR4 TNF
26
Show member pathways
12.07 IL1B IL6 TLR2 TLR4 TNF
27
Show member pathways
12.04 CXCL8 IL1B IL6 PGF
28
Show member pathways
12 IL1B TLR2 TLR4
29 12 IL1B IL6 PTGS2 TNF
30 12 CXCL8 IL1B IL6 PTGS2 TNF
31 11.95 CXCL8 IL1B IL6 TNF
32 11.93 CXCL8 IL1B IL6
33 11.92 CXCL8 IL1B PTGS2 TLR4 TNF
34 11.88 IL1B IL6 TNF
35 11.88 CXCL8 IL1B IL6 TLR4
36 11.88 CXCL8 IL1B IL6 PTGS2 TLR4 TNF
37
Show member pathways
11.86 CXCL8 IL6 TLR4
38 11.79 IL1B IL6 PTGS2 TNF
39
Show member pathways
11.77 CXCL8 PTGS2 TNF
40 11.77 CXCL8 IL1B IL6 TLR4 TNF
41 11.76 IL1B IL6 TNF
42 11.72 CXCL8 IL1B IL6 TLR2 TLR4 TNF
43 11.71 CXCL8 IL1B IL6 TNF
44
Show member pathways
11.6 CXCL8 IL1B IL6 PTGS2 TNF
45 11.59 CXCL8 IL6 PTGS2
46 11.59 CXCL8 IL1B IL6 TLR2 TLR4 TNF
47 11.57 IL1B TLR2 TLR4 TNF
48 11.55 HP IL6 TNF
49 11.55 ESR1 PTGS2 TNF
50 11.54 CYP19A1 IL1B IL6 TNF

GO Terms for Endometrial Disease

Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CXCL8 HP IL1B IL6 OXT PGF
2 extracellular region GO:0005576 9.23 CXCL8 DSPP HP IL1B IL6 OXT

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.98 CXCL8 IL1B IL6 PTGS2 TNF
2 response to lipopolysaccharide GO:0032496 9.92 IL1B PTGS2 TLR2 TLR4
3 defense response GO:0006952 9.91 CXCL8 HP TNF
4 cellular response to lipopolysaccharide GO:0071222 9.91 CXCL8 IL1B IL6 TLR4 TNF
5 activation of MAPK activity GO:0000187 9.9 IL1B TLR4 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 ESR1 IL1B IL6 TNF
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 TLR2 TLR4 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.87 IL6 TLR2 TNF
9 response to organic substance GO:0010033 9.87 HP PTGS2 TNF
10 positive regulation of JNK cascade GO:0046330 9.86 IL1B TLR4 TNF
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.86 IL6 PTGS2 TNF
12 cellular response to mechanical stimulus GO:0071260 9.85 IL1B PTGS2 TLR4
13 positive regulation of inflammatory response GO:0050729 9.85 TLR2 TLR4 TNF
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.83 IL6 PTGS2 TNF
15 regulation of inflammatory response GO:0050727 9.83 ESR1 PTGS2 TLR4 TNF
16 response to hypoxia GO:0001666 9.81 DSPP PGF TLR2
17 positive regulation of interferon-gamma production GO:0032729 9.8 IL1B TLR4 TNF
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B TLR2 TLR4 TNF
19 inflammatory response GO:0006954 9.8 CXCL8 IL1B IL6 PTGS2 TLR2 TLR4
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.76 IL1B PTGS2 TLR4 TNF
21 negative regulation of neurogenesis GO:0050768 9.75 IL1B IL6 TNF
22 response to estradiol GO:0032355 9.74 ESR1 OXT PTGS2
23 microglial cell activation GO:0001774 9.73 TLR2 TNF
24 response to fatty acid GO:0070542 9.73 PTGS2 TLR2
25 response to organic cyclic compound GO:0014070 9.73 OXT PTGS2
26 embryonic digestive tract development GO:0048566 9.73 CXCL8 TNF
27 uterus development GO:0060065 9.73 CYP19A1 ESR1
28 androgen metabolic process GO:0008209 9.73 CYP19A1 ESR1
29 negative regulation of lipid catabolic process GO:0050995 9.72 IL1B TNF
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.72 IL1B TNF
31 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
33 positive regulation of glial cell proliferation GO:0060252 9.72 IL1B IL6 TNF
34 induction of positive chemotaxis GO:0050930 9.71 CXCL8 PGF
35 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.71 TLR2 TLR4
36 regulation of cytokine secretion GO:0050707 9.71 TLR2 TLR4
37 response to carbohydrate GO:0009743 9.71 DSPP IL1B
38 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B TLR2 TLR4 TNF
39 I-kappaB phosphorylation GO:0007252 9.7 TLR2 TLR4
40 response to molecule of bacterial origin GO:0002237 9.7 CXCL8 TLR2
41 cellular response to lipoteichoic acid GO:0071223 9.69 TLR2 TLR4
42 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.69 TLR4 TNF
43 negative regulation of lipid storage GO:0010888 9.68 IL6 TNF
44 memory GO:0007613 9.67 OXT PTGS2
45 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
46 positive regulation of prostaglandin secretion GO:0032308 9.66 IL1B OXT
47 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
48 sequestering of triglyceride GO:0030730 9.64 IL1B TNF
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
50 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TLR2 TLR4 TNF

Molecular functions related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL8 IL1B IL6 TNF
2 lipopolysaccharide receptor activity GO:0001875 8.62 TLR2 TLR4

Sources for Endometrial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....