MCID: END080
MIFTS: 46

Endometrial Disease

Categories: Reproductive diseases

Aliases & Classifications for Endometrial Disease

MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 15
Endometrial Disorder 54 71
Endometrial Diseases 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1005
NCIt 49 C3504
SNOMED-CT 67 418632009
UMLS 71 C0151622 C1720816

Summaries for Endometrial Disease

Disease Ontology : 12 A uterine disease that is located in the endometrium.

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to endometritis and endometriosis. An important gene associated with Endometrial Disease is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Mepivacaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include endometrium, breast and ovary, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Endometrial Disease

Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 589)
# Related Disease Score Top Affiliating Genes
1 endometritis 30.2 TNF TLR6 TLR4 TLR2 TLR1 SIGLEC5
2 endometriosis 30.2 PTGS2 IL6 IL1B ESR1 CYP19A1 CXCL8
3 adenomyosis 29.7 PTGS2 OXT IL6 ESR1 CYP19A1 CXCL8
4 pre-eclampsia 29.3 TNF TLR4 OXT IL6 IL1B IL10
5 tamoxifen-related endometrial lesion 11.1
6 physiological polycythemia 10.6 TNF IL1B
7 subserous uterine fibroid 10.6 OXT CYP19A1
8 external pathological resorption 10.6 TNF IL6
9 granulomatous endometritis 10.6 SDC1 ESR1
10 scorpion envenomation 10.6 TNF IL6
11 mycobacterium chelonae 10.6 TLR2 CXCL8
12 systemic onset juvenile idiopathic arthritis 10.6 TNF IL1B
13 staphylococcal toxic shock syndrome 10.5 TNF IL1B
14 mycobacterium marinum 10.5 TLR2 CXCL8
15 bagassosis 10.5 IL1B CXCL8
16 vulvar vestibulitis syndrome 10.5 TNF IL1B ESR1
17 bacterial conjunctivitis 10.5 SIGLEC5 IL1B CXCL8
18 punctate inner choroidopathy 10.5 TNF IL10
19 periodontitis, chronic 10.5 IL6 IL1B
20 tropical endomyocardial fibrosis 10.5 TNF IL10
21 eclampsia 10.5 TNF OXT IL6
22 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
23 mycobacterium kansasii 10.5 TLR2 CXCL8
24 aspiration pneumonitis 10.5 TNF OXT CXCL8
25 pustulosis of palm and sole 10.5 TNF SIGLEC5 CXCL8
26 sweat gland disease 10.5 TNF SIGLEC5 ESR1
27 sapho syndrome 10.5 TNF SIGLEC5 CXCL8
28 recurrent corneal erosion 10.5 IL6 IL1B CXCL8
29 idiopathic anterior uveitis 10.5 TNF IL6 CXCL8
30 streptococcal toxic-shock syndrome 10.5 TNF IL6 CXCL8
31 leukoregulin 10.5 PTGS2 CXCL8
32 anaerobic pneumonia 10.5 TNF IL6 IL1B
33 kashin-beck disease 10.5 TNF IL1B
34 stachybotrys chartarum 10.5 TNF IL6 IL1B
35 carbuncle 10.5 TNF IL6 IL1B
36 aortitis 10.5 TNF IL6 IL1B
37 glomeruloid hemangioma 10.5 SDC1 IL6 IL1B
38 conjunctivochalasis 10.5 IL6 IL1B CXCL8
39 lung abscess 10.5 TNF IL6 IL1B
40 cardiac sarcoidosis 10.5 TNF IL1B CXCL8
41 background diabetic retinopathy 10.5 TNF IL6 IL1B
42 hemorrhagic cystitis 10.5 TNF TLR4 IL1B
43 laryngitis 10.5 TNF IL6 IL1B
44 necrotizing fasciitis 10.5 IL6 IL1B CXCL8
45 opisthorchiasis 10.5 TNF IL1B CXCL8
46 glossitis 10.5 TNF IL6 IL1B
47 estrogen-receptor negative breast cancer 10.5 ESR1 CYP19A1 CXCL8
48 congenital cytomegalovirus 10.5 TNF TLR2 IL1B
49 central nervous system vasculitis 10.5 TNF IL6 IL1B
50 tendinitis 10.5 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease

Symptoms & Phenotypes for Endometrial Disease

MGI Mouse Phenotypes related to Endometrial Disease:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.4 CYP19A1 ERRFI1 ESR1 HP IL10 IL1B
2 hematopoietic system MP:0005397 10.39 CYP19A1 ERRFI1 ESR1 HP IL10 IL1B
3 immune system MP:0005387 10.38 CYP19A1 ERRFI1 ESR1 HP IFI30 IL10
4 homeostasis/metabolism MP:0005376 10.37 CYP19A1 ERRFI1 ESR1 HP IL10 IL1B
5 behavior/neurological MP:0005386 10.35 CYP19A1 ERRFI1 ESR1 IL10 IL6 MFN2
6 cellular MP:0005384 10.33 CYP19A1 ESR1 HP IL10 IL6 MFN2
7 integument MP:0010771 10.27 CYP19A1 ERRFI1 ESR1 IL10 IL1B IL6
8 digestive/alimentary MP:0005381 10.24 CYP19A1 ERRFI1 ESR1 IL10 IL6 OXT
9 endocrine/exocrine gland MP:0005379 10.22 CYP19A1 ERRFI1 ESR1 IL10 IL6 OXT
10 adipose tissue MP:0005375 10.18 CYP19A1 ESR1 IL6 OXT PTGS2 TLR2
11 liver/biliary system MP:0005370 10.13 CYP19A1 ERRFI1 ESR1 HP IL10 IL6
12 neoplasm MP:0002006 10.11 ERRFI1 ESR1 HP IL10 IL1B IL6
13 muscle MP:0005369 10.06 CYP19A1 ESR1 IL10 IL6 MFN2 PTGS2
14 nervous system MP:0003631 10.06 CYP19A1 ESR1 IL10 IL1B IL6 MFN2
15 renal/urinary system MP:0005367 9.91 CYP19A1 ERRFI1 ESR1 HP IL6 OXT
16 reproductive system MP:0005389 9.9 CYP19A1 ERRFI1 ESR1 IL10 IL6 OXT
17 respiratory system MP:0005388 9.56 ERRFI1 ESR1 IL10 IL6 PTGS2 TLR2
18 skeleton MP:0005390 9.36 CYP19A1 ERRFI1 ESR1 IL10 IL1B IL6

Drugs & Therapeutics for Endometrial Disease

Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3 Pharmaceutical Solutions Phase 4
4 Anesthetics Phase 4
5 Anesthetics, Local Phase 4
6
Sodium citrate Approved, Investigational Phase 3 68-04-2
7
Medroxyprogesterone acetate Approved, Investigational Phase 3 71-58-9
8
Tamoxifen Approved Phase 3 10540-29-1 2733526
9
Misoprostol Approved Phase 3 59122-46-2 5282381
10
Levonorgestrel Approved, Investigational Phase 2, Phase 3 797-63-7, 17489-40-6 13109
11
Megestrol acetate Approved, Investigational, Vet_approved Phase 2, Phase 3 595-33-5 11683
12
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
13 Citrate Phase 3
14 Contraceptive Agents, Male Phase 3
15 Estrogen Antagonists Phase 3
16 Estrogen Receptor Antagonists Phase 3
17 Hormone Antagonists Phase 3
18 Estrogen Receptor Modulators Phase 3
19 Estrogens Phase 3
20
Medroxyprogesterone Phase 3 520-85-4 10631
21 Gastrointestinal Agents Phase 3
22 Antacids Phase 3
23 Anti-Ulcer Agents Phase 3
24 Contraceptive Agents Phase 2, Phase 3
25 Hormones Phase 2, Phase 3
26 Contraceptives, Oral Phase 2, Phase 3
27 Antineoplastic Agents, Hormonal Phase 2, Phase 3
28 Central Nervous System Stimulants Phase 2, Phase 3
29
Megestrol Phase 2, Phase 3 3562-63-8 19090 3080587
30
Lenograstim Approved, Investigational Phase 2 135968-09-1
31
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
32
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
33 Albumin-Bound Paclitaxel Phase 2
34 Tubulin Modulators Phase 2
35 Antimitotic Agents Phase 2
36
protease inhibitors
37 HIV Protease Inhibitors

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Randomized Double-blind Placebo Controlled Trial to Assess the Role of Intrauterine Cornual Block (ICOB) in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 A Randomized Comparison Of Medroxyprogesterone Acetate (MA) And Observation For Prevention Of Endometrial Pathology In Postmenopausal Breast Cancer Patients Treated With Tamoxifen, Phase III Completed NCT00002920 Phase 3 medroxyprogesterone;tamoxifen citrate
3 A Randomized Comparison of Oral, Sublingual and Vaginal Misoprostol Administration in Premenopausal Women Before Operative Hysteroscopy Completed NCT01805115 Phase 3 Oral misoprostol;Sublingual misoprostol;Vaginal misoprostol;Control
4 Megestrol Acetate Plus LNG-IUS to Megestrol Acetate in Young Women With Early Endometrial Cancer Recruiting NCT03241914 Phase 2, Phase 3 Megestrol Acetate
5 Phase II Study of Weekly Paclitaxel/Carboplatin in Combination With Prophylactic G-CSF in the Treatment of Gynaecological Cancers Completed NCT01523678 Phase 2 Filgrastim;Paclitaxel;Carboplatin
6 A Single Arm Phase II Trial of BMN 673 for Inoperable, Advanced Endometrial Cancer With Retrospective PTEN, MSI and MRE11 Analysis Withdrawn NCT02127151 Phase 2 BMN 673
7 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Unknown status NCT02691715
8 Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Unknown status NCT03351673
9 HE4 is a Beneficial Biomarker in Endometrial Cancer Unknown status NCT03459976
10 Endometrial and Isthmic Microbiota During IVF Stimulation in Patients Affected With Isthmocele and Intrauterine Mucus Secretion After C-section. Completed NCT03519763
11 REM (Risk Of Endometrial Malignancy): A Proposal for a New Scoring System to Evaluate Risk of Endometrial Malignancy Completed NCT01830192
12 Evaluation of Serum Human Epididymis Secretory Protein 4 (HE4) in Benign Endometrial Disease and Endometrial Cancer Completed NCT03456791
13 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Recruiting NCT03289468
14 Low Level Laser Therapy to Endometrial Cells: A Novel Approach to Increase Endometrial Proliferation and Enhance Endometrial Receptivity Available NCT02764034

Search NIH Clinical Center for Endometrial Disease

Genetic Tests for Endometrial Disease

Anatomical Context for Endometrial Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Disease:

19
Endometrium

MalaCards organs/tissues related to Endometrial Disease:

40
Breast, Ovary, Lymph Node, Uterus, Testes, Bone, Colon

Publications for Endometrial Disease

Articles related to Endometrial Disease:

(show top 50) (show all 185)
# Title Authors PMID Year
1
[Analysis of influencing factors of endometrial disease of patients with breast cancer after operation]. 61
31874475 2019
2
Preoperative platelet morphology parameters as prognostic predictors for endometrial malignant carcinoma stage and progesterone receptor. 61
31764773 2019
3
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening. 61
31371824 2019
4
More Than Just 2 Layers: A Comprehensive Multimodality Imaging Review of Endometrial Abnormalities. 61
31307863 2019
5
Cell and biomaterial-based approaches to uterus regeneration. 61
31198582 2019
6
The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker. 61
30851892 2019
7
The Impact of Gynaecological Tumour Board Rounds on Patient Care. 61
30393059 2019
8
Event-free survival following early endometrial events in breast cancer patients treated with anti-hormonal therapy: A nationwide claims data study. 61
30633178 2019
9
Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway. 61
30392973 2018
10
The CXL12/CXCR4/CXCR7 axis in female reproductive tract disease: Review. 61
30106199 2018
11
A phase I/II study of GLIF combination chemotherapy for taxane/platinum-refractory/resistant endometrial cancer (GOGO-EM2). 61
30030584 2018
12
Comparison of endometrial assessment by transvaginal ultrasonography and hysteroscopy. 61
29904926 2018
13
Evaluation of complete blood count parameters to predict endometrial cancer. 61
29604099 2018
14
Implementing the Risk of Endometrial Malignancy Algorithm (REM) adding obesity as a predictive factor: Results of REM-B in a single-center survey. 61
29660578 2018
15
Therapeutic strategies involving uterine stem cells in reproductive medicine. 61
29652725 2018
16
Endometrial histopathology results and evaluation of endometrial cancer risk in geriatric women. 61
29725280 2018
17
Metabolomic Signature of Endometrial Cancer. 61
29235868 2018
18
Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature. 61
29295713 2018
19
Elevated Prevalence of Polycystic Ovary Syndrome and Cardiometabolic Disease in South Asian Infertility Patients. 61
27351893 2017
20
Nuclear factor-κB expression in the endometrium of normal and overweight women with polycystic ovary syndrome. 61
28617068 2017
21
Validation of REM score to predict endometrial cancer in patients with ultrasound endometrial abnormalities: results of a new independent dataset. 61
28389908 2017
22
Evaluating the Age Cutoff Criterion for Reporting Benign-Appearing Endometrial Cells in Routine Pap Tests: An 8-Year Retrospective Review. 61
28486237 2017
23
Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. 61
27895728 2016
24
Correlation between Cyr61 expression and clinicopathologic parameters in adenomyosis. 61
27644084 2016
25
Differentiation between endometrial carcinoma and atypical endometrial hyperplasia with transvaginal sonographic elastography. 61
26711550 2016
26
The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis. 61
26748390 2016
27
Stage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy? 61
27172750 2016
28
Could in-vitro studies on Ishikawa cell lines explain the endometrial safety of raloxifene? Systematic literature review and starting points for future oncological research. 61
25536299 2015
29
Endometrial Ablation in Women With Abnormal Uterine Bleeding Related to Ovulatory Dysfunction: A Cohort Study. 61
26149205 2015
30
Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. 61
26253321 2015
31
Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia. 61
25536958 2015
32
Estrogen receptor β: the guardian of the endometrium. 61
25305176 2015
33
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. 61
25297546 2014
34
Performance of multidetector CT in the evaluation of the endometrium: Measurement of endometrial thickness and detection of disease. 61
25060929 2014
35
Circulating endometrial cells in peripheral blood. 61
25195200 2014
36
Recurrent postmenopausal bleeding: a prospective cohort study. 61
24681065 2014
37
Influence of AKT on progesterone action in endometrial diseases. 61
25100707 2014
38
Surgical management of early endometrial cancer: an update and proposal of a therapeutic algorithm. 61
25063051 2014
39
Role of hysteroscopy prior to assisted reproduction techniques. 61
24067621 2014
40
Experience and results of office hysteroscopy at a primary hospital. 61
24359051 2014
41
Tissue and circulating microRNA influence reproductive function in endometrial disease. 61
24055529 2013
42
Abnormal vaginal bleeding following pharmacist prescribing of metformin leads to the detection of complex endometrial hyperplasia. 61
24285770 2013
43
Histopathologic assessment of the entire endometrium in asymptomatic women. 61
23938162 2013
44
REM (risk of endometrial malignancy): a proposal for a new scoring system to evaluate risk of endometrial malignancy. 61
23983254 2013
45
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. 61
23824412 2013
46
Cancer risk and PCOS. 61
23624028 2013
47
Endometrial surveillance in tamoxifen users: role, timing and accuracy of hysteroscopic investigation: observational longitudinal cohort study. 61
23629476 2013
48
Angiogenesis, lymphangiogenesis and neurogenesis in endometriosis. 61
23747918 2013
49
Development of endometrial carcinoma in a patient with leprechaunism (donohue syndrome). 61
23990696 2013
50
Laparoendoscopic single-site surgery with hysterectomy in patients with prior cesarean section: comparison of surgical outcomes with bladder dissection techniques. 61
23317681 2013

Variations for Endometrial Disease

Expression for Endometrial Disease

Search GEO for disease gene expression data for Endometrial Disease.

Pathways for Endometrial Disease

Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 TNF TLR6 TLR4 TLR2 TLR1 SIGLEC5
2
Show member pathways
13.49 TNF TLR6 TLR4 TLR2 TLR1 IL6
3
Show member pathways
13.39 TNF PTGS2 IL6 IL1B IL10 IFI30
4
Show member pathways
13.15 TNF TLR6 TLR4 TLR2 TLR1 IL6
5
Show member pathways
13.02 TNF TLR4 TLR2 PTGS2 IL6 IL1B
6
Show member pathways
12.93 TNF IL6 IL1B IL10 IFI30 CXCL8
7
Show member pathways
12.89 TNF TLR4 TLR2 IL6 IL1B CXCL8
8
Show member pathways
12.81 TNF TLR6 TLR4 TLR2 TLR1 IL6
9
Show member pathways
12.72 TNF TLR6 TLR4 TLR2 TLR1 PTGS2
10
Show member pathways
12.7 TNF TLR4 TLR2 IL6 IL1B IL10
11
Show member pathways
12.69 TNF TLR4 TLR2 IL6 IL1B IL10
12
Show member pathways
12.67 TNF TLR6 TLR4 TLR2 TLR1 IL1B
13 12.67 TNF TLR6 TLR2 TLR1 PTGS2 IL1B
14
Show member pathways
12.44 TNF TLR2 PTGS2 IL6 IL1B CXCL8
15 12.42 TNF TLR4 IL1B CXCL8
16
Show member pathways
12.42 TNF TLR4 SDC1 PTGS2 IL6 IL1B
17 12.41 TNF TLR6 TLR4 TLR2 IL6 IL1B
18 12.4 TNF TLR4 TLR2 SDC1 ESR1
19
Show member pathways
12.38 TNF TLR4 TLR2 PTGS2 IL1B IL10
20 12.37 TNF TLR4 IL6 IL1B CXCL8
21
Show member pathways
12.36 TNF IL6 IL10 CXCL8
22
Show member pathways
12.36 TNF PTGS2 IL6 IL1B
23
Show member pathways
12.36 TNF TLR6 TLR4 TLR2 TLR1 IL6
24 12.35 TNF TLR4 MFN2 IL6 IL1B CXCL8
25
Show member pathways
12.33 TNF IL6 IL1B IL10 CXCL8
26
Show member pathways
12.31 TNF PTGS2 IL6 IL1B IL10
27 12.27 TNF IL6 IL1B IL10 CXCL8
28 12.24 TNF TLR6 TLR4 TLR2 TLR1 PTGS2
29
Show member pathways
12.14 TLR6 TLR4 TLR2 TLR1 IL1B
30 12.13 TNF TLR4 IL6 IL1B IL10 CXCL8
31 12.12 TNF TLR4 PTGS2 IL6 IL1B CXCL8
32 12.11 TNF TLR6 TLR4 TLR2 TLR1 IL6
33 12.09 TNF PTGS2 IL6 IL1B IL10 CXCL8
34 12.08 TNF SDC1 IL6 IL10
35 12.06 TNF PTGS2 IL6 IL1B
36 12.05 TNF TLR4 PTGS2 IL1B CXCL8
37 12 TNF IL6 IL1B CXCL8
38
Show member pathways
11.98 TNF TLR6 TLR4 TLR2 TLR1 IL6
39 11.97 TNF TLR4 TLR2 IL6 IL1B CXCL8
40 11.93 TLR6 TLR4 TLR2 TLR1
41
Show member pathways
11.93 TLR6 TLR4 TLR2 TLR1 IL6 IL1B
42 11.87 TNF TLR4 TLR2 IL6 IL1B IL10
43 11.86 TNF IL6 IL1B IL10
44 11.81 TNF IL1B IL10
45 11.81 TNF TLR4 IL6 IL1B IL10 CXCL8
46
Show member pathways
11.79 TNF PTGS2 CXCL8
47
Show member pathways
11.79 TNF PTGS2 IL6 IL1B CXCL8
48 11.77 TNF IL6 IL1B CXCL8
49 11.64 TNF TLR4 TLR2 IL1B
50 11.64 TNF TLR4 TLR2 IL6 IL1B CXCL8

GO Terms for Endometrial Disease

Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.46 TNF TLR6 TLR2 TLR1
2 phagocytic vesicle membrane GO:0030670 9.13 TLR6 TLR2 TLR1
3 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 8.62 TLR2 TLR1

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.36 TLR6 TLR4 TLR2 TLR1 PTGES OXT
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.28 TNF TLR4 TLR2 IL6 IL1B IL10
3 immune system process GO:0002376 10.22 TLR6 TLR4 TLR2 TLR1 IFI30 HP
4 positive regulation of gene expression GO:0010628 10.16 TNF TLR6 TLR4 TLR2 IL6 IL1B
5 negative regulation of cell proliferation GO:0008285 10.14 TLR2 PTGS2 PTGES IL6 IL1B IL10
6 defense response to bacterium GO:0042742 10.09 TNF TLR6 TLR4 IL10 HP
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.03 TNF TLR6 TLR4 IL1B
8 defense response GO:0006952 10.02 TNF TLR1 HP CXCL8
9 cellular response to lipopolysaccharide GO:0071222 10 TNF TLR4 IL6 IL1B IL10 CXCL8
10 response to estradiol GO:0032355 9.99 PTGS2 OXT ESR1 CYP19A1
11 response to lipopolysaccharide GO:0032496 9.99 TLR4 TLR2 PTGS2 PTGES IL1B IL10
12 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 TNF IL6 IL1B IL10 ESR1
13 cytokine-mediated signaling pathway GO:0019221 9.98 TNF SDC1 PTGS2 IL6 IL1B IL10
14 positive regulation of inflammatory response GO:0050729 9.96 TNF TLR4 TLR2 IL1B
15 regulation of inflammatory response GO:0050727 9.96 TNF TLR4 PTGS2 ESR1
16 response to organic substance GO:0010033 9.96 TNF SDC1 PTGS2 IL10 HP
17 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.95 TNF TLR6 TLR4 TLR2 IL6 IL1B
18 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.94 TNF TLR4 TLR2 IL1B
19 cellular response to mechanical stimulus GO:0071260 9.93 TLR4 PTGS2 IL1B
20 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TNF PTGS2 IL6
21 toll-like receptor signaling pathway GO:0002224 9.91 TLR6 TLR4 TLR2 TLR1
22 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.9 TNF MFN2 IL10
23 positive regulation of interferon-gamma production GO:0032729 9.9 TNF TLR4 IL1B
24 negative regulation of interleukin-6 production GO:0032715 9.89 TNF TLR4 IL10
25 positive regulation of interleukin-6 secretion GO:2000778 9.89 TNF TLR4 TLR2 IL1B
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.88 TNF TLR4 TLR2 IL1B
27 positive regulation of JAK-STAT cascade GO:0046427 9.87 TNF IL6 IL10
28 microglial cell activation GO:0001774 9.87 TNF TLR6 TLR2
29 positive regulation of vascular endothelial growth factor production GO:0010575 9.87 PTGS2 IL6 IL1B
30 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.87 TLR6 TLR4 TLR2 TLR1
31 negative regulation of neurogenesis GO:0050768 9.86 TNF IL6 IL1B
32 positive regulation of interleukin-8 production GO:0032757 9.84 TNF TLR4 TLR2 IL1B
33 positive regulation of glial cell proliferation GO:0060252 9.83 TNF IL6 IL1B
34 positive regulation of macrophage activation GO:0043032 9.83 TLR6 TLR4 IL10
35 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.82 TNF IL1B IL10
36 cell activation GO:0001775 9.81 TLR6 TLR2 TLR1
37 positive regulation of neuroinflammatory response GO:0150078 9.81 TNF IL6 IL1B
38 immune response GO:0006955 9.81 TNF TLR6 TLR4 TLR2 TLR1 IL6
39 regulation of cytokine secretion GO:0050707 9.8 TLR6 TLR2 TLR1
40 response to molecule of bacterial origin GO:0002237 9.8 TLR2 IL10 CXCL8
41 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.8 TNF TLR6 TLR4 IL6
42 cellular response to bacterial lipopeptide GO:0071221 9.78 TLR6 TLR2 TLR1
43 regulation of neuroinflammatory response GO:0150077 9.76 PTGS2 IL6
44 positive regulation of chemokine production GO:0032722 9.76 TNF TLR4 TLR2 IL6
45 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.75 IL10 ERRFI1
46 cyclooxygenase pathway GO:0019371 9.75 PTGS2 PTGES
47 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.75 TNF ESR1
48 cellular response to lipoteichoic acid GO:0071223 9.75 TLR4 TLR2
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.75 TLR4 IL10
50 negative regulation of lipid storage GO:0010888 9.75 TNF IL6

Molecular functions related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 TNF IL6 IL1B IL10 CXCL8
2 amyloid-beta binding GO:0001540 9.58 TLR6 TLR4 TLR2
3 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
4 lipopeptide binding GO:0071723 9.33 TLR6 TLR2 TLR1
5 Toll-like receptor 2 binding GO:0035663 9.32 TLR6 TLR1
6 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.26 TLR6 TLR4 TLR2 TLR1
7 NAD(P)+ nucleosidase activity GO:0050135 8.92 TLR6 TLR4 TLR2 TLR1

Sources for Endometrial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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