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MCID: END080
MIFTS: 45

Endometrial Disease

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endometrial Disease

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MalaCards integrated aliases for Endometrial Disease:

Name: Endometrial Disease 12 15
Endometrial Disorder 54 71
Endometrial Diseases 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1005
NCIt 50 C3504
SNOMED-CT 67 418632009
UMLS 71 C0151622 C1720816
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Summaries for Endometrial Disease

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Disease Ontology : 12 A uterine disease that is located in the endometrium.

MalaCards based summary : Endometrial Disease, also known as endometrial disorder, is related to endometritis and endometrial hyperplasia. An important gene associated with Endometrial Disease is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Mepivacaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include endometrium, breast and ovary, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Endometrial Disease

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Diseases related to Endometrial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 679)
# Related Disease Score Top Affiliating Genes
1 endometritis 30.4 TNF TLR4 SIGLEC5 SDC1 PTGES PGR
2 endometrial hyperplasia 30.2 PGR ESR1 CYP19A1
3 progesterone resistance 30.1 PGR ESR1 ERRFI1
4 endometrial adenocarcinoma 29.9 PGR IGF1 ESR1
5 endometriosis 29.5 PTGS2 PGR IL6 IL1B IGFBP1 ESR1
6 tamoxifen-related endometrial lesion 10.9
7 external pathological resorption 10.4 TNF IL6
8 scorpion envenomation 10.4 TNF IL6
9 mycobacterium chelonae 10.4 TLR2 CXCL8
10 staphylococcal toxic shock syndrome 10.4 TNF IL1B
11 punctate inner choroidopathy 10.4 TNF IL10
12 mycobacterium marinum 10.4 TLR2 CXCL8
13 glassy cell carcinoma of the cervix 10.4 PGR ESR1
14 breast intraductal papillomatosis 10.4 PGR ESR1
15 nipple carcinoma 10.4 PGR ESR1
16 bartholin's gland adenoma 10.4 PGR ESR1
17 bartholin's gland adenoid cystic carcinoma 10.4 PGR ESR1
18 uterine corpus adenosarcoma 10.4 PGR ESR1
19 bartholin's gland benign neoplasm 10.4 PGR ESR1
20 chronic tympanitis 10.4 PGR ESR1
21 vestibular gland benign neoplasm 10.4 PGR ESR1
22 tropical endomyocardial fibrosis 10.4 TNF IL10
23 vulvar vestibulitis syndrome 10.4 TNF IL1B ESR1
24 aspiration pneumonitis 10.4 TNF OXT CXCL8
25 vulvar syringoma 10.4 PGR ESR1
26 pustulosis of palm and sole 10.4 TNF SIGLEC5 CXCL8
27 periodontitis, chronic 10.4 IL6 IL1B
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
29 mycobacterium kansasii 10.4 TLR2 CXCL8
30 pasteurellosis 10.4 TNF HP CXCL8
31 toxicodendron dermatitis 10.4 TNF CXCL8
32 idiopathic anterior uveitis 10.4 TNF IL6 CXCL8
33 haemophilus meningitis 10.4 TNF OXT IL1B
34 streptococcal toxic-shock syndrome 10.4 TNF IL6 CXCL8
35 suppurative periapical periodontitis 10.4 IL6 IL1B CXCL8
36 physiological polycythemia 10.4 TNF IL6 IL1B
37 asphyxia neonatorum 10.4 OXT IL6 IL1B
38 recurrent corneal erosion 10.4 IL6 IL1B CXCL8
39 kashin-beck disease 10.3 TNF IL1B
40 diffuse peritoneal leiomyomatosis 10.3 PGR CYP19A1
41 inflammatory bowel disease 25 10.3 TNF PTGS2
42 cardiac sarcoidosis 10.3 TNF IL1B CXCL8
43 neurotic disorder 10.3 TNF OXT IL6
44 glomeruloid hemangioma 10.3 SDC1 IL6 IL1B
45 opisthorchiasis 10.3 TNF IL1B CXCL8
46 lung leiomyoma 10.3 PGR ESR1
47 ulcer of lower limbs 10.3 TNF IL6 IL1B
48 cardiogenic shock 10.3 TNF IL6
49 subserous uterine fibroid 10.3 PGR OXT CYP19A1
50 multifocal choroiditis 10.3 TNF IL10

Graphical network of the top 20 diseases related to Endometrial Disease:



Diseases related to Endometrial Disease
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Symptoms & Phenotypes for Endometrial Disease

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MGI Mouse Phenotypes related to Endometrial Disease:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.49 CYP19A1 ERRFI1 ESR1 HP IGF1 IL10
2 homeostasis/metabolism MP:0005376 10.47 CYP19A1 ERRFI1 ESR1 HP IGF1 IL10
3 hematopoietic system MP:0005397 10.45 CYP19A1 ERRFI1 ESR1 HP IGF1 IL10
4 immune system MP:0005387 10.45 CYP19A1 ERRFI1 ESR1 HP IGF1 IGFBP1
5 cellular MP:0005384 10.42 CYP19A1 ESR1 HP IGF1 IGFBP1 IL10
6 integument MP:0010771 10.41 CYP19A1 ERRFI1 ESR1 IGF1 IL10 IL1A
7 endocrine/exocrine gland MP:0005379 10.34 CYP19A1 ERRFI1 ESR1 IGF1 IL10 IL6
8 mortality/aging MP:0010768 10.3 ERRFI1 ESR1 HP IGF1 IL10 IL1B
9 digestive/alimentary MP:0005381 10.27 CYP19A1 ERRFI1 ESR1 IL10 IL6 OXT
10 neoplasm MP:0002006 10.25 ERRFI1 ESR1 HP IGF1 IL10 IL1A
11 adipose tissue MP:0005375 10.24 CYP19A1 ESR1 IGF1 IL6 OXT PTGS2
12 liver/biliary system MP:0005370 10.22 CYP19A1 ERRFI1 ESR1 HP IGFBP1 IL10
13 muscle MP:0005369 10.13 CYP19A1 ESR1 IGF1 IL10 IL6 PGR
14 limbs/digits/tail MP:0005371 10.04 ERRFI1 ESR1 IGF1 IL10 PGR TLR4
15 normal MP:0002873 9.97 CYP19A1 ERRFI1 ESR1 IGF1 IL10 PGR
16 renal/urinary system MP:0005367 9.96 CYP19A1 ERRFI1 ESR1 HP IGF1 IL6
17 reproductive system MP:0005389 9.93 CYP19A1 ERRFI1 ESR1 IGF1 IL10 IL6
18 no phenotypic analysis MP:0003012 9.91 ERRFI1 ESR1 IL10 PGR PTGES PTGS2
19 respiratory system MP:0005388 9.61 ERRFI1 ESR1 IGF1 IL10 IL6 PTGS2
20 skeleton MP:0005390 9.4 CYP19A1 ERRFI1 ESR1 IGF1 IL10 IL1B
Sources

Drugs & Therapeutics for Endometrial Disease

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Drugs for Endometrial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
2
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
3 Pharmaceutical Solutions Phase 4
4 Anesthetics, Local Phase 4
5 Anesthetics Phase 4
6
Misoprostol Approved Phase 3 59122-46-2 5282381
7 Gastrointestinal Agents Phase 3
8 Anti-Ulcer Agents Phase 3
9 Antacids Phase 3
10
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
11
Progesterone Approved, Vet_approved 57-83-0 5994
12
Polyestradiol phosphate Approved 28014-46-2
13 HIV Protease Inhibitors
14
protease inhibitors
15 Hormones
16 Estradiol 3-benzoate
17 Triptorelin Pamoate
18 Estradiol 17 beta-cypionate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Double-blind Placebo Controlled Trial to Assess the Role of Intrauterine Cornual Block (ICOB) in Combination With Direct Cervical Block in Outpatient Endometrial Ablation Completed NCT01808898 Phase 4
2 A Randomized Comparison of Oral, Sublingual and Vaginal Misoprostol Administration in Premenopausal Women Before Operative Hysteroscopy Completed NCT01805115 Phase 3 Oral misoprostol;Sublingual misoprostol;Vaginal misoprostol;Control
3 HE4 is a Beneficial Biomarker in Endometrial Cancer Unknown status NCT03459976
4 Study of Diagnosis of Color Power Doppler Combined Minimally Invasive Sampling for Endometrial Diseases Unknown status NCT03289468
5 Intrauterine Saline Washing for Detection Endometrial Disease in Patients With Abnormal Uterine Bleeding Unknown status NCT02691715
6 Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Endometrial Volume as a Predictor of Endometrial Pathology in Perimenopausal Uterine Bleeding Unknown status NCT03351673
7 Endometrial and Isthmic Microbiota During IVF Stimulation in Patients Affected With Isthmocele and Intrauterine Mucus Secretion After C-section. Completed NCT03519763
8 REM (Risk Of Endometrial Malignancy): A Proposal for a New Scoring System to Evaluate Risk of Endometrial Malignancy Completed NCT01830192
9 Evaluation of Serum Human Epididymis Secretory Protein 4 (HE4) in Benign Endometrial Disease and Endometrial Cancer Completed NCT03456791
10 Endometrial Compaction and Its Influence on Pregnancy Rate in Frozen Embryo Cycle Regimes Not yet recruiting NCT04454749

Search NIH Clinical Center for Endometrial Disease

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Genetic Tests for Endometrial Disease

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Anatomical Context for Endometrial Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Disease:

19
Endometrium

MalaCards organs/tissues related to Endometrial Disease:

40
Breast, Ovary, Lymph Node, Uterus, Colon, T Cells
Sources

Publications for Endometrial Disease

About this section

Articles related to Endometrial Disease:

(show top 50) (show all 189)
# Title Authors PMID Year
1
Is sleep deficit associated with infertility and recurrent pregnancy losses? Results from a prospective cohort study. 61
32981061 2021
2
More Than Just 2 Layers: A Comprehensive Multimodality Imaging Review of Endometrial Abnormalities. 61
31307863 2020
3
Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches. 61
33142944 2020
4
Endometrial Organoids: A New Model for the Research of Endometrial-Related Diseases†. 61
32697306 2020
5
[Clinical analysis of 30 patients with atypical glandular hyperplasia or malignant transformation in foci of adenomyosis]. 61
32842251 2020
6
Transplantation of Human Adipose Stem Cells Using Acellular Human Amniotic Membrane Improves Angiogenesis in Injured Endometrial Tissue in a Rat Intrauterine Adhesion Model. 61
32838542 2020
7
[Analysis of influencing factors of endometrial disease of patients with breast cancer after operation]. 61
31874475 2019
8
Preoperative platelet morphology parameters as prognostic predictors for endometrial malignant carcinoma stage and progesterone receptor. 61
31764773 2019
9
Patient-derived organoids from endometrial disease capture clinical heterogeneity and are amenable to drug screening. 61
31371824 2019
10
Cell and biomaterial-based approaches to uterus regeneration. 61
31198582 2019
11
The prognostic significance of positive peritoneal cytology in endometrial cancer and its correlations with L1-CAM biomarker. 61
30851892 2019
12
The Impact of Gynaecological Tumour Board Rounds on Patient Care. 61
30393059 2019
13
Event-free survival following early endometrial events in breast cancer patients treated with anti-hormonal therapy: A nationwide claims data study. 61
30633178 2019
14
Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway. 61
30392973 2018
15
The CXL12/CXCR4/CXCR7 axis in female reproductive tract disease: Review. 61
30106199 2018
16
A phase I/II study of GLIF combination chemotherapy for taxane/platinum-refractory/resistant endometrial cancer (GOGO-EM2). 61
30030584 2018
17
Comparison of endometrial assessment by transvaginal ultrasonography and hysteroscopy. 61
29904926 2018
18
Evaluation of complete blood count parameters to predict endometrial cancer. 61
29604099 2018
19
Implementing the Risk of Endometrial Malignancy Algorithm (REM) adding obesity as a predictive factor: Results of REM-B in a single-center survey. 61
29660578 2018
20
Therapeutic strategies involving uterine stem cells in reproductive medicine. 61
29652725 2018
21
Endometrial histopathology results and evaluation of endometrial cancer risk in geriatric women. 61
29725280 2018
22
Metabolomic Signature of Endometrial Cancer. 61
29235868 2018
23
Pathological and molecular diagnosis of bilateral inguinal lymph nodes metastases from low-grade endometrial adenocarcinoma: a case report with review of the literature. 61
29295713 2018
24
Elevated Prevalence of Polycystic Ovary Syndrome and Cardiometabolic Disease in South Asian Infertility Patients. 61
27351893 2017
25
Nuclear factor-κB expression in the endometrium of normal and overweight women with polycystic ovary syndrome. 61
28617068 2017
26
Validation of REM score to predict endometrial cancer in patients with ultrasound endometrial abnormalities: results of a new independent dataset. 61
28389908 2017
27
Evaluating the Age Cutoff Criterion for Reporting Benign-Appearing Endometrial Cells in Routine Pap Tests: An 8-Year Retrospective Review. 61
28486237 2017
28
Quantitative contrast-enhanced ultrasonography for the differential diagnosis of endometrial hyperplasia and endometrial neoplasms. 61
27895728 2016
29
Correlation between Cyr61 expression and clinicopathologic parameters in adenomyosis. 61
27644084 2016
30
Differentiation between endometrial carcinoma and atypical endometrial hyperplasia with transvaginal sonographic elastography. 61
26711550 2016
31
The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis. 61
26748390 2016
32
Stage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy? 61
27172750 2016
33
Could in-vitro studies on Ishikawa cell lines explain the endometrial safety of raloxifene? Systematic literature review and starting points for future oncological research. 61
25536299 2015
34
Endometrial Ablation in Women With Abnormal Uterine Bleeding Related to Ovulatory Dysfunction: A Cohort Study. 61
26149205 2015
35
Potential role of cervicovaginal extracellular particles in diagnosis of endometriosis. 61
26253321 2015
36
Efficacy of the Levonorgestrel-Releasing Intrauterine System on IVF-ET Outcomes in PCOS With Simple Endometrial Hyperplasia. 61
25536958 2015
37
Estrogen receptor β: the guardian of the endometrium. 61
25305176 2015
38
The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. 61
25297546 2014
39
Performance of multidetector CT in the evaluation of the endometrium: Measurement of endometrial thickness and detection of disease. 61
25060929 2014
40
Circulating endometrial cells in peripheral blood. 61
25195200 2014
41
Recurrent postmenopausal bleeding: a prospective cohort study. 61
24681065 2014
42
Influence of AKT on progesterone action in endometrial diseases. 61
25100707 2014
43
Surgical management of early endometrial cancer: an update and proposal of a therapeutic algorithm. 61
25063051 2014
44
Role of hysteroscopy prior to assisted reproduction techniques. 61
24067621 2014
45
Experience and results of office hysteroscopy at a primary hospital. 61
24359051 2014
46
Tissue and circulating microRNA influence reproductive function in endometrial disease. 61
24055529 2013
47
Abnormal vaginal bleeding following pharmacist prescribing of metformin leads to the detection of complex endometrial hyperplasia. 61
24285770 2013
48
Histopathologic assessment of the entire endometrium in asymptomatic women. 61
23938162 2013
49
REM (risk of endometrial malignancy): a proposal for a new scoring system to evaluate risk of endometrial malignancy. 61
23983254 2013
50
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. 61
23824412 2013
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Variations for Endometrial Disease

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Expression for Endometrial Disease

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Search GEO for disease gene expression data for Endometrial Disease.
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Pathways for Endometrial Disease

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Pathways related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.87 TNF PTGS2 IL6 IL1B IL1A IL10
2
PEDF Induced Signaling 63
Show member pathways
 13.74 TNF TLR4 PTGS2 PTGES IL6 IL1B
3
Akt Signaling 63
Show member pathways
 13.49 TNF TLR4 TLR2 IL6 IL1B IL1A
4
Cytokine Signaling in Immune system 65
Show member pathways
 13.4 TNF PTGS2 IL6 IL1B IL1A IL10
5
PAK Pathway 63
Show member pathways
 13.35 TNF IL6 IL1B IL1A IL10 IGF1
6
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13.13 TNF TLR4 TLR2 IL6 IL1B IL10
7
PI3K-Akt signaling pathway 36
Show member pathways
 13.05 TNF TLR4 TLR2 PTGS2 IL6 IGF1
8
Human cytomegalovirus infection 36
Show member pathways
 13.03 TNF TLR4 TLR2 PTGS2 IL6 IL1B
9
Allograft rejection 36 1
Show member pathways
 12.93 TNF IL6 IL1B IL1A IL10 CXCL8
10
Measles 36
Show member pathways
 12.92 TNF TLR4 TLR2 IL6 IL1B IL1A
11
Salmonella infection (KEGG) 36
Show member pathways
 12.82 TNF TLR4 TLR2 IL6 IL1B CXCL8
12
NF-KappaB Family Pathway 63
Show member pathways
 12.82 TNF TLR4 TLR2 IL6 IL1B IL1A
13
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.8 TNF TLR4 TLR2 PTGS2 IL6 IL1B
14
T cell receptor signaling pathway 36
Show member pathways
 12.71 TNF TLR4 TLR2 IL6 IL1B IL1A
15
Th17 cell differentiation 36
Show member pathways
 12.7 TNF TLR4 TLR2 IL6 IL1B IL1A
16
TRAF Pathway 63
Show member pathways
 12.65 TNF TLR4 TLR2 IL1B IL1A
17
NF-kappaB Signaling 4
12.63 TNF TLR2 PTGS2 IL1B IL10
18
IL-17 Family Signaling Pathways 64
Show member pathways
 12.45 TNF TLR2 PTGS2 IL6 IL1B CXCL8
19
Proteoglycans in cancer 36
12.43 TNF TLR4 TLR2 SDC1 IGF1 ESR1
20
Toll Comparative Pathway 63
Show member pathways
 12.41 TNF TLR4 SDC1 PTGS2 IL6 IL1B
21
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.39 TNF TLR4 TLR2 IL6 IL1A CXCL8
22
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.38 TNF IL6 IL10 CXCL8
23
Folate Metabolism 1
Show member pathways
 12.38 TNF PTGS2 IL6 IL1B
24
Toxoplasmosis 36
Show member pathways
 12.38 TNF TLR4 TLR2 PTGS2 IL1B IL1A
25
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.37 TNF IL6 IL1B IL1A IL10 IGF1
26
Tuberculosis 36
12.35 TNF TLR4 TLR2 IL6 IL1B IL1A
27
NOD-like receptor signaling pathway 36
12.34 TNF TLR4 IL6 IL1B CXCL8
28
C-type lectin receptor signaling pathway 36
Show member pathways
 12.31 TNF PTGS2 IL6 IL1B IL10
29
Bacterial infections in CF airways 23
Show member pathways
 12.31 TNF TLR4 TLR2 IL6 IL1B CXCL8
30
Colorectal Cancer Metastasis 63
12.29 TNF TLR4 TLR2 PTGS2 IL6
31
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.29 TNF IL6 IL1B IL1A IL10 CXCL8
32
Necroptosis 36
Show member pathways
 12.26 TNF TLR4 IL1B IL1A
33
Yersinia infection 36
12.19 TNF TLR4 IL6 IL1B IL10 CXCL8
34
Fluid shear stress and atherosclerosis 36
12.16 TNF SDC1 IL1B IL1A
35
MAPK Pathway 70
Show member pathways
 12.11 TLR4 TLR2 IL1B IL1A
36
Senescence and Autophagy in Cancer 1
12.08 IL6 IL1B IL1A IGF1 CXCL8
37
Spinal Cord Injury 1
12.08 TNF TLR4 PTGS2 IL6 IL1B IL1A
38
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.07 TNF SDC1 IL6 IL10
39
NF-kappa B signaling pathway 36
12.07 TNF TLR4 PTGS2 IL1B CXCL8
40
TNF signaling pathway 36
12.06 TNF PTGS2 IL6 IL1B
41
AGE-RAGE signaling pathway in diabetic complications 36
12.04 TNF IL6 IL1B IL1A CXCL8
42
Interleukin-4 and 13 signaling 65
12.03 TNF PTGS2 IL6 IL1B IL1A IL10
43
Hematopoietic cell lineage 36
12 TNF IL6 IL1B IL1A
44
Amoebiasis 36
11.96 TNF TLR4 TLR2 IL6 IL1B IL10
45
Th17 Differentiation Pathway 64
Show member pathways
 11.95 TLR4 TLR2 IL6 IL1B
46
Th1 Differentiation Pathway 64
Show member pathways
 11.88 TNF TLR4 TLR2 IL6 IL1B IL10
47
Dendritic Cells Developmental Lineage Pathway 64
11.86 TNF IL6 IL1B IL10
48
Innate Lymphoid Cell Differentiation Pathways 64
11.83 TNF IL1B IL10
49
Rheumatoid arthritis 36
11.83 TNF TLR4 TLR2 IL6 IL1B IL1A
50
IgA-Producing B Cells in the Intestine 64
11.82 TNF TLR4 TLR2 IL6 IL10
Sources

GO Terms for Endometrial Disease

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Cellular components related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF SDC1 OXT IL6 IL1B IL1A
2 extracellular space GO:0005615 9.32 TNF OXT IL6 IL1B IL1A IL10

Biological processes related to Endometrial Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 TLR4 TLR2 PTGES PGR OXT IL6
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.25 TNF TLR4 TLR2 PGR IL6 IL1A
3 positive regulation of transcription, DNA-templated GO:0045893 10.19 TNF IL6 IL1B IL10 IGF1 ESR1
4 negative regulation of gene expression GO:0010629 10.09 TNF PGR IGF1 ESR1 CXCL8
5 positive regulation of gene expression GO:0010628 10.06 TNF TLR4 TLR2 IL6 IL1B IL1A
6 immune response GO:0006955 10.03 TNF TLR4 TLR2 IL6 IL1B IL1A
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.02 TNF TLR4 TLR2 IL6 IL1B
8 negative regulation of cell proliferation GO:0008285 10.01 TLR2 PTGS2 PTGES IL6 IL1B IL1A
9 activation of MAPK activity GO:0000187 9.98 TNF TLR4 IL1B IGF1
10 response to estradiol GO:0032355 9.97 PTGS2 OXT ESR1 CYP19A1
11 positive regulation of DNA-binding transcription factor activity GO:0051091 9.97 TNF IL6 IL1B IL10 ESR1
12 positive regulation of inflammatory response GO:0050729 9.95 TNF TLR4 TLR2 IL1B
13 positive regulation of tumor necrosis factor production GO:0032760 9.95 TLR4 TLR2 IL6 IL1A
14 response to lipopolysaccharide GO:0032496 9.95 TLR4 TLR2 PTGS2 PTGES IL1B IL10
15 response to organic substance GO:0010033 9.94 TNF SDC1 PTGS2 IL10
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.93 TNF TLR4 TLR2 IL1B
17 regulation of inflammatory response GO:0050727 9.93 TNF TLR4 PTGS2 PTGES ESR1
18 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF PTGS2 IL6 IGF1
19 negative regulation of tumor necrosis factor production GO:0032720 9.9 TLR4 IL10 IGF1
20 regulation of insulin secretion GO:0050796 9.9 TNF IL6 IL1B
21 negative regulation of interleukin-6 production GO:0032715 9.9 TNF TLR4 IL10
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 TNF IL6 IGF1
23 positive regulation of interferon-gamma production GO:0032729 9.89 TNF TLR4 IL1B
24 positive regulation of interleukin-1 beta production GO:0032731 9.89 TNF TLR4 IL6
25 positive regulation of cytokine production GO:0001819 9.89 TNF IL1A IL10
26 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.88 TNF IL10 IGF1
27 response to activity GO:0014823 9.88 OXT IL6 IL10
28 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 TNF TLR4 PTGS2 IL1B
29 positive regulation of chemokine production GO:0032722 9.88 TNF TLR4 TLR2 IL6
30 protein kinase B signaling GO:0043491 9.87 TNF IL1B IGF1
31 positive regulation of interleukin-10 production GO:0032733 9.87 TLR4 TLR2 IL6
32 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.86 TNF IL1B IL1A
33 positive regulation of JAK-STAT cascade GO:0046427 9.85 TNF IL6 IL10
34 positive regulation of mitotic nuclear division GO:0045840 9.85 IL1B IL1A IGF1
35 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 TNF TLR4 TLR2 IL1B
36 negative regulation of neurogenesis GO:0050768 9.83 TNF IL6 IL1B
37 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.83 TNF TLR4 IL6
38 positive regulation of glial cell proliferation GO:0060252 9.81 TNF IL6 IL1B
39 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.81 TNF IL1B IL10
40 positive regulation of vascular endothelial growth factor production GO:0010575 9.81 PTGS2 IL6 IL1B IL1A
41 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 TLR2 IL6 IL1B IL1A
42 cellular response to lipopolysaccharide GO:0071222 9.8 TNF TLR4 IL6 IL1B IL1A IL10
43 positive regulation of neuroinflammatory response GO:0150078 9.79 TNF IL6 IL1B
44 response to molecule of bacterial origin GO:0002237 9.78 TLR2 IL10 CXCL8
45 positive regulation of prostaglandin secretion GO:0032308 9.77 PTGES OXT IL1B
46 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR4 TLR2 IL6 IL1B
47 cytokine-mediated signaling pathway GO:0019221 9.76 TNF SDC1 PTGS2 IL6 IL1B IL1A
48 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.73 TNF TLR4
49 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
50 cellular response to lipoteichoic acid GO:0071223 9.73 TLR4 TLR2

Molecular functions related to Endometrial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL6 IL1B IL1A IL10 CXCL8
2 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
Sources

Sources for Endometrial Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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