MCID: END001
MIFTS: 31

Endometrial Mucinous Adenocarcinoma

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Endometrial Mucinous Adenocarcinoma

MalaCards integrated aliases for Endometrial Mucinous Adenocarcinoma:

Name: Endometrial Mucinous Adenocarcinoma 12 15 73
Uterine Corpus Mucinous Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3707
NCIt 50 C40144
UMLS 73 C1519859

Summaries for Endometrial Mucinous Adenocarcinoma

MalaCards based summary : Endometrial Mucinous Adenocarcinoma, also known as uterine corpus mucinous adenocarcinoma, is related to mucinous adenocarcinoma and adenocarcinoma in situ. An important gene associated with Endometrial Mucinous Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are DNA Damage and Cell cycle Role of SCF complex in cell cycle regulation. The drugs Nintedanib and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related phenotypes are embryo and reproductive system

Related Diseases for Endometrial Mucinous Adenocarcinoma

Diseases related to Endometrial Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 30.9 CDKN2A MUC1
2 adenocarcinoma in situ 29.8 CDKN2A PAX2
3 mucinous bronchioloalveolar adenocarcinoma 10.6 CDKN2A MUC1
4 cholangiolocellular carcinoma 10.6 CDKN2A MUC1
5 sarcomatoid mesothelioma 10.6 CDKN2A MUC1
6 ischemic fasciitis 10.6 CDKN2A MUC1
7 well-differentiated liposarcoma 10.6 CDKN2A MUC1
8 breast mucoepidermoid carcinoma 10.6 MUC1 PGR
9 endosalpingiosis 10.6 MUC1 PGR
10 dedifferentiated liposarcoma 10.6 CDKN2A MUC1
11 clear cell meningioma 10.6 MUC1 PGR
12 plasmablastic lymphoma 10.6 CDKN2A MUC1
13 meningeal melanocytoma 10.6 CDKN2A MUC1
14 vulvar dystrophy 10.6 CDKN2A PGR
15 bizarre leiomyoma 10.6 CDKN2A PGR
16 sertoli-leydig cell tumor 10.6 MUC1 PGR
17 biliary tract neoplasm 10.5 CDKN2A MUC1
18 papillary tumor of the pineal region 10.5 MUC1 VIM
19 parachordoma 10.5 MUC1 VIM
20 ossifying fibromyxoid tumor 10.5 MUC1 VIM
21 fibrous meningioma 10.5 MUC1 VIM
22 chordoid meningioma 10.5 MUC1 VIM
23 chickenpox 10.5 MUC1 PGR
24 nodular hidradenoma 10.5 MUC1 VIM
25 syringocystadenoma papilliferum 10.5 MUC1 VIM
26 eccrine porocarcinoma 10.5 MUC1 VIM
27 breast secretory carcinoma 10.5 MUC1 PGR
28 biphasic synovial sarcoma 10.5 MUC1 VIM
29 adenofibroma 10.5 MUC1 VIM
30 myxopapillary ependymoma 10.5 MUC1 VIM
31 monophasic synovial sarcoma 10.5 MUC1 VIM
32 spiradenoma 10.5 MUC1 VIM
33 hidradenoma 10.5 MUC1 VIM
34 desmoplastic small round cell tumor 10.5 MUC1 VIM
35 anaplastic ependymoma 10.5 MUC1 VIM
36 reticulum cell sarcoma 10.5 MUC1 VIM
37 sertoli cell tumor 10.5 MUC1 VIM
38 mucinous cystadenocarcinoma 10.5 MUC1 VIM
39 endocervical carcinoma 10.5 CDKN2A ESR1
40 mesenchymal chondrosarcoma 10.5 MUC1 VIM
41 extraskeletal ewing sarcoma 10.5 MUC1 VIM
42 lobular neoplasia 10.5 ESR1 MUC1
43 perineurioma 10.5 MUC1 VIM
44 pancreatic ductal carcinoma 10.5 CDKN2A MUC1
45 spindle cell sarcoma 10.5 MUC1 VIM
46 chondroid chordoma 10.4 MUC1 VIM
47 vulvar syringoma 10.4 ESR1 PGR
48 lung leiomyoma 10.4 ESR1 PGR
49 vestibular gland benign neoplasm 10.4 ESR1 PGR
50 bartholin's gland adenoma 10.4 ESR1 PGR

Graphical network of the top 20 diseases related to Endometrial Mucinous Adenocarcinoma:



Diseases related to Endometrial Mucinous Adenocarcinoma

Symptoms & Phenotypes for Endometrial Mucinous Adenocarcinoma

MGI Mouse Phenotypes related to Endometrial Mucinous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.35 PGR VIM CDKN2A ESR1 PAX2
2 reproductive system MP:0005389 9.02 PAX2 PGR VIM CDKN2A ESR1

Drugs & Therapeutics for Endometrial Mucinous Adenocarcinoma

Drugs for Endometrial Mucinous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nintedanib Approved Phase 2 656247-17-5 56843413
2 Antibodies Phase 2,Phase 1
3 Immunoglobulin Fc Fragments Phase 2
4 Immunoglobulins Phase 2,Phase 1
5 Mitogens Phase 2,Phase 1
6 tyrosine Nutraceutical Phase 2
7
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
8
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
9
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
10
Bevacizumab Approved, Investigational Phase 1 216974-75-3
11 Albumin-Bound Paclitaxel Phase 1
12 Antimitotic Agents Phase 1
13 Antineoplastic Agents, Phytogenic Phase 1
14 Protein Kinase Inhibitors Phase 1
15 Angiogenesis Inhibitors Phase 1
16 Angiogenesis Modulating Agents Phase 1
17 Antibodies, Monoclonal Phase 1
18 Endothelial Growth Factors Phase 1
19 Immunoglobulin G Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2 Nintedanib
2 Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01642082 Phase 2
3 Brivanib Alaninate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00888173 Phase 2 Brivanib Alaninate
4 Dasatinib, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer Completed NCT01440998 Phase 1 Carboplatin;Dasatinib;Paclitaxel
5 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Suspended NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Endometrial Mucinous Adenocarcinoma

Genetic Tests for Endometrial Mucinous Adenocarcinoma

Anatomical Context for Endometrial Mucinous Adenocarcinoma

MalaCards organs/tissues related to Endometrial Mucinous Adenocarcinoma:

41
Endothelial

Publications for Endometrial Mucinous Adenocarcinoma

Articles related to Endometrial Mucinous Adenocarcinoma:

# Title Authors Year
1
Papillary mucinous metaplasia of the endometrium as a possible precursor of endometrial mucinous adenocarcinoma. ( 22766790 )
2012
2
Lobular endocervical glandular hyperplasia with extensive mucinous differentiation of endometrium and endometrial mucinous adenocarcinoma in situ: a case report and review of literature. ( 21605894 )
2011
3
Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma. ( 16409624 )
2006

Variations for Endometrial Mucinous Adenocarcinoma

Expression for Endometrial Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Endometrial Mucinous Adenocarcinoma.

Pathways for Endometrial Mucinous Adenocarcinoma

Pathways related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.8 CDKN2A MKI67 VIM
2
Show member pathways
11.38 CDKN2A ESR1 PGR
3 10.67 MKI67 PAX2 VIM

GO Terms for Endometrial Mucinous Adenocarcinoma

Biological processes related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.26 CDKN2A ESR1 PAX2 PGR
2 steroid hormone mediated signaling pathway GO:0043401 9.16 ESR1 PGR
3 stem cell differentiation GO:0048863 8.62 ESR1 PAX2

Molecular functions related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.72 CDKN2A ESR1 MKI67 PAX2 PGR
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.54 ESR1 MUC1 PGR
3 transcription factor binding GO:0008134 9.33 CDKN2A ESR1 PAX2
4 steroid hormone receptor activity GO:0003707 9.26 ESR1 PGR
5 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
6 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Endometrial Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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