MCID: END001
MIFTS: 30

Endometrial Mucinous Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Mucinous Adenocarcinoma

MalaCards integrated aliases for Endometrial Mucinous Adenocarcinoma:

Name: Endometrial Mucinous Adenocarcinoma 12 15 73
Uterine Corpus Mucinous Adenocarcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3707
NCIt 50 C40144
UMLS 73 C1519859

Summaries for Endometrial Mucinous Adenocarcinoma

Disease Ontology : 12 An endometrial adenocarcinoma that derives from epithelial cells originating in glandular tissue, which produce mucin.

MalaCards based summary : Endometrial Mucinous Adenocarcinoma, also known as uterine corpus mucinous adenocarcinoma, is related to mucinous adenocarcinoma and adenocarcinoma in situ. An important gene associated with Endometrial Mucinous Adenocarcinoma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are DNA Damage and Cell cycle Role of SCF complex in cell cycle regulation. The drugs Nintedanib and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and breast, and related phenotypes are embryo and reproductive system

Related Diseases for Endometrial Mucinous Adenocarcinoma

Diseases related to Endometrial Mucinous Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 mucinous adenocarcinoma 30.7 CDKN2A MUC1
2 adenocarcinoma in situ 29.9 CDKN2A PAX2
3 adenocarcinoma 10.2
4 cholecystitis 10.2 CDKN2A MUC1
5 pancreatic ductal carcinoma 10.2 CDKN2A MUC1
6 malignant pleural mesothelioma 10.2 CDKN2A MUC1
7 neurofibroma 10.2 CDKN2A MUC1
8 pneumothorax 10.2 MUC1 PGR
9 breast mucoepidermoid carcinoma 10.2 MUC1 PGR
10 cholangiolocellular carcinoma 10.2 CDKN2A MUC1
11 endosalpingiosis 10.2 MUC1 PGR
12 sarcoma, synovial 10.2 MUC1 VIM
13 oncocytoma 10.2 MUC1 VIM
14 osteofibrous dysplasia 10.2 MUC1 VIM
15 rhabdoid tumor predisposition syndrome 1 10.2 MUC1 VIM
16 angiosarcoma 10.2 MUC1 VIM
17 cystadenoma 10.2 MUC1 PGR
18 giant cell tumor 10.2 MUC1 VIM
19 pleomorphic adenoma 10.2 MUC1 VIM
20 optic nerve glioma 10.2 MUC1 VIM
21 epithelioid sarcoma 10.2 MUC1 VIM
22 ischemic fasciitis 10.2 CDKN2A MUC1
23 vulvar dystrophy 10.2 CDKN2A PGR
24 bizarre leiomyoma 10.2 CDKN2A PGR
25 mucinous bronchioloalveolar adenocarcinoma 10.2 CDKN2A MUC1
26 well-differentiated liposarcoma 10.2 CDKN2A MUC1
27 bone cancer 10.2 CDKN2A ESR1
28 chondromyxoid fibroma 10.2 CDKN2A VIM
29 papillary tumor of the pineal region 10.2 MUC1 VIM
30 parachordoma 10.2 MUC1 VIM
31 secretory meningioma 10.2 MUC1 VIM
32 syringocystadenoma papilliferum 10.2 MUC1 VIM
33 ossifying fibromyxoid tumor 10.1 MUC1 VIM
34 fibrous meningioma 10.1 MUC1 VIM
35 chordoid meningioma 10.1 MUC1 VIM
36 plasmablastic lymphoma 10.1 CDKN2A MUC1
37 bartholin's gland disease 10.1 CDKN2A PGR
38 nodular hidradenoma 10.1 MUC1 VIM
39 hidradenoma 10.1 MUC1 VIM
40 clear cell ependymoma 10.1 MUC1 VIM
41 eccrine porocarcinoma 10.1 MUC1 VIM
42 leiomyoma, uterine 10.1 ESR1 PGR
43 adenomyosis 10.1 ESR1 PGR
44 biphasic synovial sarcoma 10.1 MUC1 VIM
45 female breast cancer 10.1 ESR1 PGR
46 estrogen-receptor positive breast cancer 10.1 ESR1 PGR
47 estrogen-receptor negative breast cancer 10.1 ESR1 PGR
48 gynecomastia 10.1 ESR1 PGR
49 sweat gland cancer 10.1 ESR1 PGR
50 angiomyolipoma 10.1 ESR1 PGR

Graphical network of the top 20 diseases related to Endometrial Mucinous Adenocarcinoma:



Diseases related to Endometrial Mucinous Adenocarcinoma

Symptoms & Phenotypes for Endometrial Mucinous Adenocarcinoma

MGI Mouse Phenotypes related to Endometrial Mucinous Adenocarcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.35 CDKN2A ESR1 PAX2 PGR VIM
2 reproductive system MP:0005389 9.02 CDKN2A ESR1 PAX2 PGR VIM

Drugs & Therapeutics for Endometrial Mucinous Adenocarcinoma

Drugs for Endometrial Mucinous Adenocarcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nintedanib Approved Phase 2 656247-17-5 56843413
2 tyrosine Phase 2
3 Immunologic Factors Phase 2,Phase 1
4 Antibodies Phase 2,Phase 1
5 Immunoglobulins Phase 2,Phase 1
6 Immunoglobulin Fc Fragments Phase 2
7 Mitogens Phase 2,Phase 1
8
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
9
Carboplatin Approved Phase 1 41575-94-4 10339178 38904 498142
10
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
11
Bevacizumab Approved, Investigational Phase 1 216974-75-3
12 Antineoplastic Agents, Phytogenic Phase 1
13 Protein Kinase Inhibitors Phase 1
14 Antimitotic Agents Phase 1
15 Albumin-Bound Paclitaxel Phase 1
16 Angiogenesis Modulating Agents Phase 1
17 Endothelial Growth Factors Phase 1
18 Immunoglobulin G Phase 1
19 Antibodies, Monoclonal Phase 1
20 Angiogenesis Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2 Nintedanib
2 Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01642082 Phase 2
3 Brivanib Alaninate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00888173 Phase 2 Brivanib Alaninate
4 Dasatinib, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer Completed NCT01440998 Phase 1 Carboplatin;Dasatinib;Paclitaxel
5 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Endometrial Mucinous Adenocarcinoma

Genetic Tests for Endometrial Mucinous Adenocarcinoma

Anatomical Context for Endometrial Mucinous Adenocarcinoma

MalaCards organs/tissues related to Endometrial Mucinous Adenocarcinoma:

41
Lung, Bone, Breast, Ovary, Prostate, Cervix, Smooth Muscle

Publications for Endometrial Mucinous Adenocarcinoma

Articles related to Endometrial Mucinous Adenocarcinoma:

# Title Authors Year
1
Papillary mucinous metaplasia of the endometrium as a possible precursor of endometrial mucinous adenocarcinoma. ( 22766790 )
2012
2
Lobular endocervical glandular hyperplasia with extensive mucinous differentiation of endometrium and endometrial mucinous adenocarcinoma in situ: a case report and review of literature. ( 21605894 )
2011
3
Inclusion of MUC1 (Ma695) in a panel of immunohistochemical markers is useful for distinguishing between endocervical and endometrial mucinous adenocarcinoma. ( 16409624 )
2006

Variations for Endometrial Mucinous Adenocarcinoma

Expression for Endometrial Mucinous Adenocarcinoma

Search GEO for disease gene expression data for Endometrial Mucinous Adenocarcinoma.

Pathways for Endometrial Mucinous Adenocarcinoma

Pathways related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.8 CDKN2A MKI67 VIM
2
Show member pathways
11.38 CDKN2A ESR1 PGR
3 10.67 MKI67 PAX2 VIM

GO Terms for Endometrial Mucinous Adenocarcinoma

Cellular components related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.17 CDKN2A ESR1 MKI67 MUC1 PAX2 PGR

Biological processes related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 CDKN2A ESR1 PAX2 PGR
2 steroid hormone mediated signaling pathway GO:0043401 9.16 ESR1 PGR
3 stem cell differentiation GO:0048863 8.96 ESR1 PAX2
4 transcription, DNA-templated GO:0006351 8.8 ESR1 PAX2 PGR

Molecular functions related to Endometrial Mucinous Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.72 CDKN2A ESR1 MKI67 PAX2 PGR
2 transcription factor binding GO:0008134 9.43 CDKN2A ESR1 PAX2
3 steroid hormone receptor activity GO:0003707 9.16 ESR1 PGR
4 nuclear receptor activity GO:0004879 8.96 ESR1 PGR
5 steroid binding GO:0005496 8.62 ESR1 PGR

Sources for Endometrial Mucinous Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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