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MCID: END013
MIFTS: 31

Endometrial Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Endometrial Small Cell Carcinoma

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MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma 12 15 17 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7139
NCIt 49 C40155
UMLS 71 C1516858
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Summaries for Endometrial Small Cell Carcinoma

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Disease Ontology : 12 An small cell carcinoma that has material basis in small cells and located in the endometrium.

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and malignant melanocytic neoplasm of the peripheral nerve sheath. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include endometrium, lung and breast, and related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Endometrial Small Cell Carcinoma

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Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 28.1 SYP PTPRC PDGFRA NCAM1 KIT GAST
2 malignant melanocytic neoplasm of the peripheral nerve sheath 10.5 SYP ENO2
3 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
4 cerebral neuroblastoma 10.5 SYP ENO2
5 papillary tumor of the pineal region 10.5 SYP ENO2
6 intracranial primitive neuroectodermal tumor 10.5 SYP ENO2
7 bile duct mucinous adenocarcinoma 10.5 SYP ENO2
8 nodular prostate 10.5 SYP ENO2
9 cloacogenic carcinoma 10.5 SYP ENO2
10 cerebellar liponeurocytoma 10.5 SYP ENO2
11 papillary ependymoma 10.5 SYP ENO2
12 optic nerve astrocytoma 10.5 SYP ENO2
13 frontal lobe neoplasm 10.5 SYP ENO2
14 lung combined type small cell carcinoma 10.5 SYP NCAM1
15 pineal parenchymal tumor of intermediate differentiation 10.5 SYP ENO2
16 hypoganglionosis 10.5 SYP NCAM1
17 adrenal neuroblastoma 10.5 SYP ENO2
18 vaginal endometrial stromal sarcoma 10.5 SYP ENO2
19 reticular perineurioma 10.5 PDGFRA KIT
20 primitive neuroectodermal tumor of the cervix uteri 10.5 PTPRC ENO2
21 plexiform schwannoma 10.4 KIT ENO2
22 rhabdoid meningioma 10.4 SYP ENO2
23 deep leiomyoma 10.4 PDGFRA KIT
24 retroperitoneal hemangiopericytoma 10.4 KIT ENO2
25 spinal cord oligodendroglioma 10.4 SYP ENO2
26 heart leiomyosarcoma 10.4 PDGFRA KIT
27 orbital cancer 10.4 NCAM1 ENO2
28 vulvar apocrine adenocarcinoma 10.4 PTPRC ENO2
29 thymus sarcomatoid carcinoma 10.4 SYP AFP
30 endobronchial lipoma 10.4 SYP ENO2
31 cerebellar medulloblastoma 10.4 SYP ENO2
32 malignant sertoli cell tumor 10.4 ENO2 AFP
33 small intestine leiomyoma 10.4 PDGFRA KIT
34 cerebrovascular benign neoplasm 10.4 SYP ENO2
35 gastric leiomyoma 10.4 PDGFRA KIT
36 pulmonary vein stenosis 10.4 PDGFRA KIT
37 clear cell ependymoma 10.4 SYP ENO2
38 biliary tract benign neoplasm 10.4 SYP NCAM1
39 extraosseous ewing sarcoma 10.4 SYP ENO2
40 gastric leiomyosarcoma 10.4 PDGFRA KIT
41 cerebellum cancer 10.4 SYP ENO2
42 breast hemangiopericytoma 10.4 PTPRC KIT
43 hypereosinophilic syndrome, idiopathic 10.4 PDGFRA KIT
44 ovarian cystic teratoma 10.4 SYP AFP
45 central nervous system primitive neuroectodermal neoplasm 10.4 SYP ENO2
46 askin's tumor 10.4 SYP ENO2
47 sm-ahnmd 10.4 PDGFRA KIT
48 breast leiomyosarcoma 10.4 KIT ENO2
49 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.4 PDGFRA KIT
50 paratesticular lipoma 10.4 ENO2 AFP

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:



Diseases related to Endometrial Small Cell Carcinoma
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Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

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MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.61 AFP ENO2 KIT NCAM1 PDGFRA PPY
2 endocrine/exocrine gland MP:0005379 9.17 AFP CHGA GAST KIT PDGFRA PTPRC
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Drugs & Therapeutics for Endometrial Small Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

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Genetic Tests for Endometrial Small Cell Carcinoma

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Anatomical Context for Endometrial Small Cell Carcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Small Cell Carcinoma:

19
Endometrium

MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

40
Lung, Breast, Bone, Ovary, Prostate, Pineal, Thymus
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Publications for Endometrial Small Cell Carcinoma

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Articles related to Endometrial Small Cell Carcinoma:

(show all 11)
# Title Authors PMID Year
1
Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases. 61
30057027 2018
2
Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. 61
25400430 2014
3
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases. 61
25286790 2014
4
Primary endometrial small cell carcinoma. 61
22185556 2012
5
KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes. 61
20035340 2010
6
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. 61
17606050 2007
7
Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis. 61
12841676 2003
8
Rare case of small-cell carcinoma arising from the endometrium with paraneoplastic retinopathy. 61
9887249 1998
9
Exfoliative cytology of neuroendocrine small cell carcinoma of the endometrium. A report of two cases. 61
9684589 1998
10
Small-cell carcinoma of the endometrium: an immunohistochemical and ultrastructural analysis. 61
9094811 1997
11
Neuroendocrine differentiation in müllerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed müllerian tumor containing small-cell carcinoma. 61
3020961 1986
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Variations for Endometrial Small Cell Carcinoma

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Expression for Endometrial Small Cell Carcinoma

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Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.
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Pathways for Endometrial Small Cell Carcinoma

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Pathways related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.2 VIP SYP NCAM1 ENO2
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.64 PTPRC NCAM1 KIT
3
Innate Lymphoid Cell Differentiation Pathways 64
11.4 PTPRC NCAM1 KIT
4
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.33 SYP PDGFRA NCAM1
5
Dendritic Cells Developmental Lineage Pathway 64
11.2 PTPRC NCAM1 KIT
6
Cardiac Progenitor Differentiation 1
10.52 PDGFRA NCAM1 KIT
7
Gastric acid production 1
9.8 VIP GAST
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GO Terms for Endometrial Small Cell Carcinoma

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Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 PYY PPY KIT GAST ENO2 CHGA
2 external side of plasma membrane GO:0009897 9.46 PTPRC PDGFRA NCAM1 KIT
3 mast cell granule GO:0042629 9.26 KIT CHGA
4 extracellular region GO:0005576 9.23 VIP SPINK5 PYY PPY NCAM1 GAST

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hematopoietic progenitor cell differentiation GO:0002244 9.33 PTPRC PDGFRA KIT
2 mast cell degranulation GO:0043303 9.32 KIT CHGA
3 positive regulation of phospholipase C activity GO:0010863 9.26 PDGFRA KIT
4 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
5 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.13 VIP PYY PPY
2 hormone activity GO:0005179 8.92 VIP PYY PPY GAST
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Sources for Endometrial Small Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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