Endometrial Small Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endometrial Small Cell Carcinoma

MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7139

NCIt ⁵⁰ C40155

UMLS ⁷³ C1516858

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Summaries for Endometrial Small Cell Carcinoma

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and ureter small cell carcinoma. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include tongue, and related phenotypes are behavior/neurological and cellular

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Related Diseases for Endometrial Small Cell Carcinoma

Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)

#	Related Disease	Score	Top Affiliating Genes
1	small cell carcinoma	28.7	ENO2 KIT NCAM1 PDGFRA PTPRC SYP
2	ureter small cell carcinoma	10.9	ENO2 SYP
3	urinary bladder small cell neuroendocrine carcinoma	10.9	ENO2 SYP
4	auditory system cancer	10.9	ENO2 SYP
5	sinonasal undifferentiated carcinoma	10.9	ENO2 SYP
6	pancreatic somatostatinoma	10.9	ENO2 SYP
7	small cell carcinoma of the bladder	10.8	ENO2 SYP
8	papillary tumor of the pineal region	10.8	ENO2 SYP
9	middle ear adenoma	10.8	ENO2 SYP
10	ovarian carcinosarcoma	10.8	ENO2 SYP
11	pulmonary large cell neuroendocrine carcinoma	10.8	ENO2 SYP
12	atypical follicular adenoma	10.8	ENO2 SYP
13	central nervous system primitive neuroectodermal neoplasm	10.8	ENO2 SYP
14	cerebellum cancer	10.8	ENO2 SYP
15	subependymal glioma	10.8	ENO2 SYP
16	olfactory nerve neoplasm	10.8	ENO2 SYP
17	cerebral neuroblastoma	10.8	ENO2 SYP
18	cauda equina neoplasm	10.8	ENO2 SYP
19	extraosseous chondrosarcoma	10.8	ENO2 SYP
20	benign ependymoma	10.8	ENO2 SYP
21	astroblastoma	10.8	ENO2 SYP
22	cerebral ventricle cancer	10.8	ENO2 SYP
23	cerebrum cancer	10.8	ENO2 SYP
24	pineal gland cancer	10.8	ENO2 SYP
25	melanotic neuroectodermal tumor	10.8	ENO2 SYP
26	nodular ganglioneuroblastoma	10.8	ENO2 SYP
27	primitive neuroectodermal tumor of the cervix uteri	10.8	ENO2 PTPRC
28	supratentorial cancer	10.8	ENO2 SYP
29	mucinous ovarian cystadenoma	10.8	ENO2 SYP
30	pineocytoma	10.8	ENO2 SYP
31	respiratory system benign neoplasm	10.8	ENO2 SYP
32	desmoplastic small round cell tumor	10.8	ENO2 SYP
33	carcinoid tumors, intestinal	10.8	ENO2 SYP
34	bone benign neoplasm	10.8	ENO2 SYP
35	kidney rhabdoid cancer	10.8	ENO2 PTPRC
36	multiple mucosal neuroma	10.8	ENO2 NCAM1
37	meningeal melanomatosis	10.8	ENO2 SYP
38	papillary ependymoma	10.8	ENO2 SYP
39	lung meningioma	10.8	ENO2 NCAM1
40	connective tissue benign neoplasm	10.8	ENO2 SYP
41	glomus tumor	10.7	ENO2 SYP
42	choriocarcinoma of ovary	10.7	ENO2 NCAM1
43	intraocular retinoblastoma	10.7	ENO2 SYP
44	esophageal neuroendocrine tumor	10.7	NCAM1 SYP
45	sclerosing hemangioma	10.7	ENO2 SYP
46	subependymal giant cell astrocytoma	10.7	ENO2 SYP
47	central neurocytoma	10.7	ENO2 SYP
48	ovarian large-cell neuroendocrine carcinoma	10.7	NCAM1 SYP
49	lung combined type small cell carcinoma	10.7	NCAM1 SYP
50	carcinoid syndrome	10.7	ENO2 SYP

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:

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Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.91	PDGFRA AFP ENO2 SYP F2 KIT
2	cellular	MP:0005384	9.87	NCAM1 PDGFRA PTPRC ENO2 SMUG1 UBC
3	mortality/aging	MP:0010768	9.86	PDGFRA PTPRC AFP SMUG1 F2 UBC
4	neoplasm	MP:0002006	9.55	PDGFRA PTPRC AFP SMUG1 KIT
5	nervous system	MP:0003631	9.5	NCAM1 PDGFRA PTPRC ENO2 SYP F2
6	respiratory system	MP:0005388	9.02	PDGFRA PTPRC ENO2 F2 KIT

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Drugs & Therapeutics for Endometrial Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

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Genetic Tests for Endometrial Small Cell Carcinoma

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Anatomical Context for Endometrial Small Cell Carcinoma

MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

⁴¹

Tongue

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Publications for Endometrial Small Cell Carcinoma

Articles related to Endometrial Small Cell Carcinoma:

#	Title	Authors	Year
1	Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. ( 25400430 )	Wan Q....Deng Y.	2014
2	Primary endometrial small cell carcinoma. ( 22185556 )	Kurtay G....SertAselik A.	2012
3	Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. ( 17606050 )	Marioni G....Staffieri A.	2007
4	Neuroendocrine differentiation in mA1llerian neoplasms. An immunohistochemical study of a &quot;pure&quot; endometrial small-cell carcinoma and a mixed mA1llerian tumor containing small-cell carcinoma. ( 3020961 )	Manivel C....Sibley R.K.	1986

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Genes for Endometrial Small Cell Carcinoma

Genes related to Endometrial Small Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	15.32	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	SYP	Synaptophysin	Protein Coding	14.74	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	14.38	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.48	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	AFP	Alpha Fetoprotein	Protein Coding	13.2	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	F2	Coagulation Factor II, Thrombin	Protein Coding	13.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	13.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	UBC	Ubiquitin C	Protein Coding	5.22	DISEASES inferred ¹⁵

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Variations for Endometrial Small Cell Carcinoma

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Expression for Endometrial Small Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.

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Pathways for Endometrial Small Cell Carcinoma

Pathways related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ⁴	12.16	ENO2 NCAM1 SYP UBC
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.61	KIT NCAM1 PTPRC
3	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.34	KIT NCAM1 PTPRC
4	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.23	NCAM1 PDGFRA SYP
5	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11	KIT NCAM1 PTPRC
6	Cardiac Progenitor Differentiation ¹	10.52	KIT NCAM1 PDGFRA

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GO Terms for Endometrial Small Cell Carcinoma

Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.26	KIT NCAM1 PDGFRA PTPRC
2	external side of plasma membrane	GO:0009897	9.02	F2 KIT NCAM1 PDGFRA PTPRC

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.58	AFP F2 UBC
2	T cell differentiation	GO:0030217	9.43	KIT PTPRC
3	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.37	KIT PDGFRA
4	positive regulation of JAK-STAT cascade	GO:0046427	9.32	F2 KIT
5	negative regulation of platelet activation	GO:0010544	9.26	F2 PDGFRA
6	MAPK cascade	GO:0000165	9.26	KIT NCAM1 PDGFRA UBC
7	positive regulation of phospholipase C activity	GO:0010863	9.16	KIT PDGFRA
8	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	8.8	F2 KIT PDGFRA

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras guanyl-nucleotide exchange factor activity	GO:0005088	8.8	KIT NCAM1 PDGFRA

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