Endometrial Small Cell Carcinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endometrial Small Cell Carcinoma

MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7139

NCIt ⁵⁰ C40155

UMLS ⁷³ C1516858

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Summaries for Endometrial Small Cell Carcinoma

Disease Ontology : ¹² An small cell carcinoma that has_material_basis in small cells and located in the endometrium.

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and chondrosarcoma, extraskeletal myxoid. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Developmental Biology and Neuroscience. Affiliated tissues include lung, kidney and bone, and related phenotypes are behavior/neurological and nervous system

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Related Diseases for Endometrial Small Cell Carcinoma

Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)

#	Related Disease	Score	Top Affiliating Genes
1	small cell carcinoma	29.7	ENO2 KIT NCAM1 PDGFRA PTPRC SYP
2	chondrosarcoma, extraskeletal myxoid	10.3	ENO2 SYP
3	central nervous system benign neoplasm	10.3	ENO2 SYP
4	malignant pheochromocytoma	10.3	ENO2 SYP
5	optic nerve neoplasm	10.3	ENO2 SYP
6	medullomyoblastoma	10.3	ENO2 SYP
7	adult medulloblastoma	10.3	ENO2 SYP
8	optic nerve glioma	10.3	ENO2 SYP
9	pineal parenchymal tumor of intermediate differentiation	10.3	ENO2 SYP
10	ganglioglioma	10.3	ENO2 SYP
11	basaloid squamous cell carcinoma	10.3	ENO2 SYP
12	cerebellar liponeurocytoma	10.3	ENO2 SYP
13	cerebral primitive neuroectodermal tumor	10.3	ENO2 SYP
14	granulosa cell tumor of the ovary	10.3	ENO2 SYP
15	horseshoe kidney	10.3	ENO2 SYP
16	adenosquamous lung carcinoma	10.2	ENO2 PDGFRA
17	carotid body cancer	10.2	ENO2 SYP
18	urinary bladder small cell neuroendocrine carcinoma	10.2	ENO2 SYP
19	auditory system cancer	10.2	ENO2 SYP
20	bone ewing's sarcoma	10.2	ENO2 PTPRC
21	sinonasal undifferentiated carcinoma	10.2	ENO2 SYP
22	pancreatic somatostatinoma	10.2	ENO2 SYP
23	cloacogenic carcinoma	10.2	ENO2 PTPRC
24	small cell carcinoma of the bladder	10.2	ENO2 SYP
25	papillary tumor of the pineal region	10.2	ENO2 SYP
26	sensory organ benign neoplasm	10.2	ENO2 SYP
27	middle ear adenoma	10.2	ENO2 SYP
28	rhabdoid tumor predisposition syndrome 1	10.2	PTPRC SYP
29	pulmonary large cell neuroendocrine carcinoma	10.2	ENO2 SYP
30	atypical follicular adenoma	10.2	ENO2 SYP
31	central nervous system primitive neuroectodermal neoplasm	10.2	ENO2 SYP
32	cerebellum cancer	10.2	ENO2 SYP
33	clear cell ependymoma	10.2	ENO2 SYP
34	rhabdoid cancer	10.2	ENO2 SYP
35	cerebral neuroblastoma	10.2	ENO2 SYP
36	cauda equina neoplasm	10.2	ENO2 SYP
37	extraosseous chondrosarcoma	10.2	ENO2 SYP
38	subependymal glioma	10.2	ENO2 SYP
39	astroblastoma	10.2	ENO2 SYP
40	cerebral ventricle cancer	10.2	ENO2 SYP
41	olfactory nerve neoplasm	10.2	ENO2 SYP
42	primitive neuroectodermal tumor of the cervix uteri	10.2	ENO2 PTPRC
43	pineal gland cancer	10.2	ENO2 SYP
44	autonomic nervous system benign neoplasm	10.2	ENO2 SYP
45	melanotic neuroectodermal tumor	10.2	ENO2 SYP
46	benign ependymoma	10.2	ENO2 SYP
47	nodular ganglioneuroblastoma	10.2	ENO2 SYP
48	ganglioneuroblastoma	10.2	ENO2 SYP
49	pineocytoma	10.2	ENO2 SYP
50	multiple mucosal neuroma	10.2	ENO2 NCAM1

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:

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Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.7	AFP ENO2 F2 KIT NCAM1 PDGFRA
2	nervous system	MP:0003631	9.5	ENO2 F2 KIT NCAM1 PDGFRA PTPRC
3	respiratory system	MP:0005388	9.02	ENO2 F2 KIT PDGFRA PTPRC

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Drugs & Therapeutics for Endometrial Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

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Genetic Tests for Endometrial Small Cell Carcinoma

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Anatomical Context for Endometrial Small Cell Carcinoma

MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

⁴¹

Lung, Kidney, Bone, Colon, Ovary, Testis, Pineal

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Small Cell Carcinoma:

¹⁹

The Endometrium

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Publications for Endometrial Small Cell Carcinoma

Articles related to Endometrial Small Cell Carcinoma:

#	Title	Authors	Year
1	Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. ( 25400430 )	Wan Q....Deng Y.	2014
2	Primary endometrial small cell carcinoma. ( 22185556 )	Kurtay G....SertAselik A.	2012
3	Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. ( 17606050 )	Marioni G....Staffieri A.	2007
4	Neuroendocrine differentiation in mA1llerian neoplasms. An immunohistochemical study of a &quot;pure&quot; endometrial small-cell carcinoma and a mixed mA1llerian tumor containing small-cell carcinoma. ( 3020961 )	Manivel C....Sibley R.K.	1986

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Genes for Endometrial Small Cell Carcinoma

Genes related to Endometrial Small Cell Carcinoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	15.18	DISEASES inferred ¹⁵
2	SYP	Synaptophysin	Protein Coding	14.61	DISEASES inferred ¹⁵
3	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	14.28	DISEASES inferred ¹⁵
4	PTPRC	Protein Tyrosine Phosphatase, Receptor Type C	Protein Coding	13.58	DISEASES inferred ¹⁵
5	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	13.5	DISEASES inferred ¹⁵
6	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.37	DISEASES inferred ¹⁵
7	F2	Coagulation Factor II, Thrombin	Protein Coding	13.04	DISEASES inferred ¹⁵
8	AFP	Alpha Fetoprotein	Protein Coding	12.98	DISEASES inferred ¹⁵
9	UBC	Ubiquitin C	Protein Coding	5.09	DISEASES inferred ¹⁵

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Variations for Endometrial Small Cell Carcinoma

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Expression for Endometrial Small Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.

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Pathways for Endometrial Small Cell Carcinoma

Pathways related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.01	KIT NCAM1 PDGFRA PTPRC UBC
2	Neuroscience ⁴	12.16	ENO2 NCAM1 SYP UBC
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.61	KIT NCAM1 PTPRC
4	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.34	KIT NCAM1 PTPRC
5	Neural Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.23	NCAM1 PDGFRA SYP
6	FOXA2 and FOXA3 transcription factor networks ¹	11.08	AFP F2
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11	KIT NCAM1 PTPRC
8	Cardiac Progenitor Differentiation ¹	10.52	KIT NCAM1 PDGFRA

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GO Terms for Endometrial Small Cell Carcinoma

Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.26	KIT NCAM1 PDGFRA PTPRC
2	external side of plasma membrane	GO:0009897	9.02	F2 KIT NCAM1 PDGFRA PTPRC

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of ERK1 and ERK2 cascade	GO:0070374	9.65	KIT PDGFRA PTPRC
2	MAPK cascade	GO:0000165	9.63	KIT NCAM1 PDGFRA
3	cellular protein metabolic process	GO:0044267	9.58	AFP F2 UBC
4	positive regulation of MAPK cascade	GO:0043410	9.5	KIT PDGFRA PTPRC
5	T cell differentiation	GO:0030217	9.49	KIT PTPRC
6	positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552	9.43	KIT PDGFRA
7	positive regulation of JAK-STAT cascade	GO:0046427	9.37	F2 KIT
8	activation of MAPK activity	GO:0000187	9.33	KIT PTPRC UBC
9	positive regulation of phospholipase C activity	GO:0010863	9.26	KIT PDGFRA
10	negative regulation of platelet activation	GO:0010544	8.96	F2 PDGFRA
11	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	8.8	F2 KIT PDGFRA

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Ras guanyl-nucleotide exchange factor activity	GO:0005088	8.8	KIT NCAM1 PDGFRA

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