MCID: END013
MIFTS: 32

Endometrial Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Small Cell Carcinoma

MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7139
NCIt 50 C40155
UMLS 73 C1516858

Summaries for Endometrial Small Cell Carcinoma

Disease Ontology : 12 An small cell carcinoma that has_material_basis in small cells and located in the endometrium.

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and chondrosarcoma, extraskeletal myxoid. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Developmental Biology and Neuroscience. Affiliated tissues include lung, kidney and bone, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Endometrial Small Cell Carcinoma

Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 29.7 ENO2 KIT NCAM1 PDGFRA PTPRC SYP
2 chondrosarcoma, extraskeletal myxoid 10.3 ENO2 SYP
3 central nervous system benign neoplasm 10.3 ENO2 SYP
4 malignant pheochromocytoma 10.3 ENO2 SYP
5 optic nerve neoplasm 10.3 ENO2 SYP
6 medullomyoblastoma 10.3 ENO2 SYP
7 adult medulloblastoma 10.3 ENO2 SYP
8 optic nerve glioma 10.3 ENO2 SYP
9 pineal parenchymal tumor of intermediate differentiation 10.3 ENO2 SYP
10 ganglioglioma 10.3 ENO2 SYP
11 basaloid squamous cell carcinoma 10.3 ENO2 SYP
12 cerebellar liponeurocytoma 10.3 ENO2 SYP
13 cerebral primitive neuroectodermal tumor 10.3 ENO2 SYP
14 granulosa cell tumor of the ovary 10.3 ENO2 SYP
15 horseshoe kidney 10.3 ENO2 SYP
16 adenosquamous lung carcinoma 10.2 ENO2 PDGFRA
17 carotid body cancer 10.2 ENO2 SYP
18 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
19 auditory system cancer 10.2 ENO2 SYP
20 bone ewing's sarcoma 10.2 ENO2 PTPRC
21 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
22 pancreatic somatostatinoma 10.2 ENO2 SYP
23 cloacogenic carcinoma 10.2 ENO2 PTPRC
24 small cell carcinoma of the bladder 10.2 ENO2 SYP
25 papillary tumor of the pineal region 10.2 ENO2 SYP
26 sensory organ benign neoplasm 10.2 ENO2 SYP
27 middle ear adenoma 10.2 ENO2 SYP
28 rhabdoid tumor predisposition syndrome 1 10.2 PTPRC SYP
29 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
30 atypical follicular adenoma 10.2 ENO2 SYP
31 central nervous system primitive neuroectodermal neoplasm 10.2 ENO2 SYP
32 cerebellum cancer 10.2 ENO2 SYP
33 clear cell ependymoma 10.2 ENO2 SYP
34 rhabdoid cancer 10.2 ENO2 SYP
35 cerebral neuroblastoma 10.2 ENO2 SYP
36 cauda equina neoplasm 10.2 ENO2 SYP
37 extraosseous chondrosarcoma 10.2 ENO2 SYP
38 subependymal glioma 10.2 ENO2 SYP
39 astroblastoma 10.2 ENO2 SYP
40 cerebral ventricle cancer 10.2 ENO2 SYP
41 olfactory nerve neoplasm 10.2 ENO2 SYP
42 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 PTPRC
43 pineal gland cancer 10.2 ENO2 SYP
44 autonomic nervous system benign neoplasm 10.2 ENO2 SYP
45 melanotic neuroectodermal tumor 10.2 ENO2 SYP
46 benign ependymoma 10.2 ENO2 SYP
47 nodular ganglioneuroblastoma 10.2 ENO2 SYP
48 ganglioneuroblastoma 10.2 ENO2 SYP
49 pineocytoma 10.2 ENO2 SYP
50 multiple mucosal neuroma 10.2 ENO2 NCAM1

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:



Diseases related to Endometrial Small Cell Carcinoma

Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 AFP ENO2 F2 KIT NCAM1 PDGFRA
2 nervous system MP:0003631 9.5 ENO2 F2 KIT NCAM1 PDGFRA PTPRC
3 respiratory system MP:0005388 9.02 ENO2 F2 KIT PDGFRA PTPRC

Drugs & Therapeutics for Endometrial Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

Genetic Tests for Endometrial Small Cell Carcinoma

Anatomical Context for Endometrial Small Cell Carcinoma

MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

41
Lung, Kidney, Bone, Colon, Ovary, Testis, Pineal

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Small Cell Carcinoma:

19
The Endometrium

Publications for Endometrial Small Cell Carcinoma

Articles related to Endometrial Small Cell Carcinoma:

# Title Authors Year
1
Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. ( 25400430 )
2014
2
Primary endometrial small cell carcinoma. ( 22185556 )
2012
3
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. ( 17606050 )
2007
4
Neuroendocrine differentiation in mA1llerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed mA1llerian tumor containing small-cell carcinoma. ( 3020961 )
1986

Variations for Endometrial Small Cell Carcinoma

Expression for Endometrial Small Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.

Pathways for Endometrial Small Cell Carcinoma

GO Terms for Endometrial Small Cell Carcinoma

Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 KIT NCAM1 PDGFRA PTPRC
2 external side of plasma membrane GO:0009897 9.02 F2 KIT NCAM1 PDGFRA PTPRC

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.65 KIT PDGFRA PTPRC
2 MAPK cascade GO:0000165 9.63 KIT NCAM1 PDGFRA
3 cellular protein metabolic process GO:0044267 9.58 AFP F2 UBC
4 positive regulation of MAPK cascade GO:0043410 9.5 KIT PDGFRA PTPRC
5 T cell differentiation GO:0030217 9.49 KIT PTPRC
6 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.43 KIT PDGFRA
7 positive regulation of JAK-STAT cascade GO:0046427 9.37 F2 KIT
8 activation of MAPK activity GO:0000187 9.33 KIT PTPRC UBC
9 positive regulation of phospholipase C activity GO:0010863 9.26 KIT PDGFRA
10 negative regulation of platelet activation GO:0010544 8.96 F2 PDGFRA
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 F2 KIT PDGFRA

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 KIT NCAM1 PDGFRA

Sources for Endometrial Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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