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MCID: END013
MIFTS: 30

Endometrial Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Endometrial Small Cell Carcinoma

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MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma 12 15 17 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7139
NCIt 50 C40155
UMLS 72 C1516858
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Summaries for Endometrial Small Cell Carcinoma

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Disease Ontology : 12 An small cell carcinoma that has material basis in small cells and located in the endometrium.

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and ependymoma. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and NF-kappaB Signaling. Affiliated tissues include tongue and endometrium, and related phenotypes are behavior/neurological and neoplasm

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Related Diseases for Endometrial Small Cell Carcinoma

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Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 27.7 SYP PTPRC PDGFRA NCAM1 KIT ENO2
2 ependymoma 10.5 SYP ENO2
3 carotid body cancer 10.5 SYP ENO2
4 urinary bladder small cell neuroendocrine carcinoma 10.5 SYP ENO2
5 auditory system cancer 10.5 SYP ENO2
6 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
7 papillary tumor of the pineal region 10.5 SYP ENO2
8 small cell carcinoma of the bladder 10.5 SYP ENO2
9 pancreatic somatostatinoma 10.5 SYP ENO2
10 middle ear adenoma 10.5 SYP ENO2
11 sensory organ benign neoplasm 10.5 SYP ENO2
12 atypical follicular adenoma 10.5 SYP ENO2
13 pulmonary large cell neuroendocrine carcinoma 10.5 SYP ENO2
14 clear cell ependymoma 10.5 SYP ENO2
15 cerebellum cancer 10.5 SYP ENO2
16 central nervous system primitive neuroectodermal neoplasm 10.5 SYP ENO2
17 cauda equina neoplasm 10.5 SYP ENO2
18 cerebral neuroblastoma 10.5 SYP ENO2
19 rhabdoid cancer 10.5 SYP ENO2
20 astroblastoma 10.5 SYP ENO2
21 subependymal glioma 10.5 SYP ENO2
22 extraosseous chondrosarcoma 10.5 SYP ENO2
23 pineal gland cancer 10.5 SYP ENO2
24 olfactory nerve neoplasm 10.5 SYP ENO2
25 cerebral ventricle cancer 10.5 SYP ENO2
26 nodular ganglioneuroblastoma 10.5 SYP ENO2
27 ganglioneuroblastoma 10.5 SYP ENO2
28 benign ependymoma 10.5 SYP ENO2
29 melanotic neuroectodermal tumor 10.5 SYP ENO2
30 autonomic nervous system benign neoplasm 10.5 SYP ENO2
31 pineocytoma 10.5 SYP ENO2
32 desmoplastic small round cell tumor 10.5 SYP ENO2
33 mucinous ovarian cystadenoma 10.5 SYP ENO2
34 respiratory system benign neoplasm 10.5 SYP ENO2
35 carcinoid tumors, intestinal 10.5 SYP ENO2
36 meningeal melanomatosis 10.5 SYP ENO2
37 bone benign neoplasm 10.5 SYP ENO2
38 papillary ependymoma 10.5 SYP ENO2
39 intraocular retinoblastoma 10.4 SYP ENO2
40 glomus tumor 10.4 SYP ENO2
41 connective tissue benign neoplasm 10.4 SYP ENO2
42 carcinoid syndrome 10.4 SYP ENO2
43 central neurocytoma 10.4 SYP ENO2
44 basaloid squamous cell carcinoma 10.4 SYP ENO2
45 subependymal giant cell astrocytoma 10.4 SYP ENO2
46 cystic teratoma 10.4 SYP ENO2
47 horseshoe kidney 10.4 SYP ENO2
48 cerebral primitive neuroectodermal tumor 10.4 SYP ENO2
49 cerebellar liponeurocytoma 10.4 SYP ENO2
50 central nervous system benign neoplasm 10.4 SYP ENO2

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:



Diseases related to Endometrial Small Cell Carcinoma
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Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

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MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 AFP ENO2 KIT NCAM1 PDGFRA SYP
2 neoplasm MP:0002006 9.26 AFP KIT PDGFRA PTPRC
3 nervous system MP:0003631 9.1 ENO2 KIT NCAM1 PDGFRA PTPRC SYP
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Drugs & Therapeutics for Endometrial Small Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

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Genetic Tests for Endometrial Small Cell Carcinoma

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Anatomical Context for Endometrial Small Cell Carcinoma

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MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

41
Tongue

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Small Cell Carcinoma:

19
Endometrium
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Publications for Endometrial Small Cell Carcinoma

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Articles related to Endometrial Small Cell Carcinoma:

(show all 11)
# Title Authors PMID Year
1
Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases. 38
30057027 2018
2
Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. 38
25400430 2014
3
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases. 38
25286790 2014
4
Primary endometrial small cell carcinoma. 38
22185556 2012
5
KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes. 38
20035340 2010
6
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. 38
17606050 2007
7
Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis. 38
12841676 2003
8
Rare case of small-cell carcinoma arising from the endometrium with paraneoplastic retinopathy. 38
9887249 1998
9
Exfoliative cytology of neuroendocrine small cell carcinoma of the endometrium. A report of two cases. 38
9684589 1998
10
Small-cell carcinoma of the endometrium: an immunohistochemical and ultrastructural analysis. 38
9094811 1997
11
Neuroendocrine differentiation in müllerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed müllerian tumor containing small-cell carcinoma. 38
3020961 1986
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Variations for Endometrial Small Cell Carcinoma

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Cosmic variations for Endometrial Small Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6981430 urinary tract,upper urinary tract,carcinoma,small cell carcinoma c.4894C>A p.L1632M 23:71135122-71135122 0
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Expression for Endometrial Small Cell Carcinoma

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Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.
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Pathways for Endometrial Small Cell Carcinoma

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Pathways related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.11 SYP NCAM1 ENO2
2
NF-kappaB Signaling 4
12.06 PTPRC NCAM1 KIT
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.56 PTPRC NCAM1 KIT
4
Innate Lymphoid Cell Differentiation Pathways 65
11.34 PTPRC NCAM1 KIT
5
Central carbon metabolism in cancer 37
11.3 PDGFRA KIT
6
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.23 SYP PDGFRA NCAM1
7
B Cell Development Pathways 65
11.16 PTPRC KIT
8
Dendritic Cells Developmental Lineage Pathway 65
11 PTPRC NCAM1 KIT
9
Cardiac Progenitor Differentiation 1
10.52 PDGFRA NCAM1 KIT
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GO Terms for Endometrial Small Cell Carcinoma

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Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 PTPRC PDGFRA NCAM1 KIT
2 cytoplasmic side of plasma membrane GO:0009898 9.16 PTPRC KIT
3 external side of plasma membrane GO:0009897 8.92 PTPRC PDGFRA NCAM1 KIT

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.43 PTPRC PDGFRA KIT
2 hematopoietic progenitor cell differentiation GO:0002244 9.4 PTPRC PDGFRA
3 T cell differentiation GO:0030217 9.37 PTPRC KIT
4 MAPK cascade GO:0000165 9.33 PDGFRA NCAM1 KIT
5 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.32 PDGFRA KIT
6 positive regulation of phospholipase C activity GO:0010863 8.96 PDGFRA KIT
7 positive regulation of MAPK cascade GO:0043410 8.8 PTPRC PDGFRA KIT

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 PDGFRA KIT
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Sources for Endometrial Small Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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