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MCID: END013
MIFTS: 29

Endometrial Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Endometrial Small Cell Carcinoma

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MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma 12 15 17 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7139
NCIt 50 C40155
UMLS 71 C1516858
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Summaries for Endometrial Small Cell Carcinoma

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Disease Ontology : 12 An small cell carcinoma that has material basis in small cells and located in the endometrium.

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and malignant melanocytic neoplasm of the peripheral nerve sheath. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include endometrium and tongue, and related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Endometrial Small Cell Carcinoma

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Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 338)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 29.2 SYP PTPRC PDGFRA NCAM1 KIT GAST
2 malignant melanocytic neoplasm of the peripheral nerve sheath 10.4 SYP ENO2
3 optic nerve astrocytoma 10.4 SYP ENO2
4 cerebral neuroblastoma 10.4 SYP ENO2
5 lung meningioma 10.4 SYP ENO2
6 sinonasal undifferentiated carcinoma 10.4 SYP ENO2
7 papillary tumor of the pineal region 10.4 SYP ENO2
8 cloacogenic carcinoma 10.4 SYP ENO2
9 intracranial primitive neuroectodermal tumor 10.4 SYP ENO2
10 bile duct mucinous adenocarcinoma 10.4 SYP ENO2
11 nodular prostate 10.4 SYP ENO2
12 cerebellar liponeurocytoma 10.4 SYP ENO2
13 frontal lobe neoplasm 10.4 SYP ENO2
14 lung combined type small cell carcinoma 10.4 SYP NCAM1
15 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
16 kidney rhabdoid cancer 10.4 SYP ENO2
17 hypoganglionosis 10.4 SYP NCAM1
18 primitive neuroectodermal tumor of the cervix uteri 10.4 PTPRC ENO2
19 spinal cord oligodendroglioma 10.4 SYP ENO2
20 angiomyoma 10.4 KIT ENO2
21 reticular perineurioma 10.4 PDGFRA KIT
22 glomangiosarcoma 10.4 SYP NCAM1
23 retroperitoneal hemangiopericytoma 10.4 KIT ENO2
24 breast leiomyosarcoma 10.4 KIT ENO2
25 small cell osteogenic sarcoma 10.3 SYP ENO2
26 endobronchial lipoma 10.3 SYP ENO2
27 deep leiomyoma 10.3 PDGFRA KIT
28 plexiform schwannoma 10.3 KIT ENO2
29 vulvar apocrine adenocarcinoma 10.3 PTPRC ENO2
30 gastric leiomyoma 10.3 PDGFRA KIT
31 bladder lateral wall cancer 10.3 SYP ENO2
32 benign perivascular tumor 10.3 SYP KIT
33 gastric leiomyosarcoma 10.3 PDGFRA KIT
34 thymus sarcomatoid carcinoma 10.3 SYP AFP
35 colon leiomyosarcoma 10.3 PDGFRA KIT
36 benign mastocytoma 10.3 PTPRC KIT
37 pulmonary vein stenosis 10.3 PDGFRA KIT
38 cerebrovascular benign neoplasm 10.3 SYP ENO2
39 rhabdoid meningioma 10.3 SYP ENO2
40 cerebellum cancer 10.3 SYP ENO2
41 small intestine leiomyoma 10.3 PDGFRA KIT
42 paratesticular lipoma 10.3 ENO2 AFP
43 lipoma of spermatic cord 10.3 ENO2 AFP
44 mediastinum seminoma 10.3 KIT AFP
45 cerebellar medulloblastoma 10.3 SYP ENO2
46 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.3 PDGFRA KIT
47 hypereosinophilic syndrome, idiopathic 10.3 PDGFRA KIT
48 askin's tumor 10.3 SYP ENO2
49 mixed germ cell tumor 10.3 KIT AFP
50 adult type testicular granulosa cell tumor 10.3 NCAM1 AFP

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:



Diseases related to Endometrial Small Cell Carcinoma
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Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

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MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10 AFP ENO2 KIT NCAM1 PDGFRA PPY
2 endocrine/exocrine gland MP:0005379 9.76 AFP CHGA GAST KIT PDGFRA PTPRC
3 nervous system MP:0003631 9.61 CHGA ENO2 KIT NCAM1 PDGFRA PTPRC
4 normal MP:0002873 9.17 KIT PDGFRA PTPRC PYY SYP TAC1
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Drugs & Therapeutics for Endometrial Small Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

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Genetic Tests for Endometrial Small Cell Carcinoma

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Anatomical Context for Endometrial Small Cell Carcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Small Cell Carcinoma:

19
Endometrium

MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

40
Tongue
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Publications for Endometrial Small Cell Carcinoma

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Articles related to Endometrial Small Cell Carcinoma:

(show all 11)
# Title Authors PMID Year
1
Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases. 61
30057027 2018
2
Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. 61
25400430 2014
3
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases. 61
25286790 2014
4
Primary endometrial small cell carcinoma. 61
22185556 2012
5
KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes. 61
20035340 2010
6
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. 61
17606050 2007
7
Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis. 61
12841676 2003
8
Rare case of small-cell carcinoma arising from the endometrium with paraneoplastic retinopathy. 61
9887249 1998
9
Exfoliative cytology of neuroendocrine small cell carcinoma of the endometrium. A report of two cases. 61
9684589 1998
10
Small-cell carcinoma of the endometrium: an immunohistochemical and ultrastructural analysis. 61
9094811 1997
11
Neuroendocrine differentiation in müllerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed müllerian tumor containing small-cell carcinoma. 61
3020961 1986
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Variations for Endometrial Small Cell Carcinoma

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Expression for Endometrial Small Cell Carcinoma

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Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.
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Pathways for Endometrial Small Cell Carcinoma

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Pathways related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.24 VIP SYP NCAM1 ENO2
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.67 PTPRC NCAM1 KIT
3
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.52 PTPRC NCAM1 KIT
4
Innate Lymphoid Cell Differentiation Pathways 64
11.4 PTPRC NCAM1 KIT
5
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.33 SYP PDGFRA NCAM1
6
Dendritic Cells Developmental Lineage Pathway 64
11.2 PTPRC NCAM1 KIT
7
Cardiac Progenitor Differentiation 1
10.52 PDGFRA NCAM1 KIT
8
Gastric acid production 1
9.8 VIP GAST
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GO Terms for Endometrial Small Cell Carcinoma

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Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 VIP TG TAC1 PYY PPY NCAM1
2 external side of plasma membrane GO:0009897 9.46 PTPRC PDGFRA NCAM1 KIT
3 extracellular space GO:0005615 9.28 TG TAC1 PYY PPY KIT GAST

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.5 TAC1 PYY PPY
2 mast cell degranulation GO:0043303 9.37 KIT CHGA
3 hematopoietic progenitor cell differentiation GO:0002244 9.33 PTPRC PDGFRA KIT
4 positive regulation of phospholipase C activity GO:0010863 9.26 PDGFRA KIT
5 mast cell chemotaxis GO:0002551 8.96 KIT CHGA
6 mast cell cytokine production GO:0032762 8.62 KIT CHGA

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide Y receptor binding GO:0031841 9.16 PYY PPY
2 neuropeptide hormone activity GO:0005184 9.13 VIP PYY PPY
3 hormone activity GO:0005179 9.02 VIP TG PYY PPY GAST
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Sources for Endometrial Small Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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