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MCID: END013
MIFTS: 32

Endometrial Small Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Endometrial Small Cell Carcinoma

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MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma 12 15 17 74

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7139
NCIt 51 C40155
UMLS 74 C1516858
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Summaries for Endometrial Small Cell Carcinoma

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Disease Ontology : 12 An small cell carcinoma that has_material_basis in small cells and located in the endometrium.

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and alveolar soft part sarcoma. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and NF-kappaB Signaling. Affiliated tissues include bone, ovary and pineal, and related phenotypes are behavior/neurological and neoplasm

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Related Diseases for Endometrial Small Cell Carcinoma

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Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 28.7 ENO2 KIT NCAM1 PDGFRA PTPRC SYP
2 alveolar soft part sarcoma 10.3 ENO2 SYP
3 chondrosarcoma, extraskeletal myxoid 10.3 ENO2 SYP
4 paraganglioma 10.3 ENO2 SYP
5 sweat gland cancer 10.3 ENO2 SYP
6 central nervous system cancer 10.3 ENO2 SYP
7 medullomyoblastoma 10.3 ENO2 SYP
8 adult medulloblastoma 10.3 ENO2 SYP
9 adrenal carcinoma 10.3 ENO2 SYP
10 optic nerve glioma 10.3 ENO2 SYP
11 pineal parenchymal tumor of intermediate differentiation 10.3 ENO2 SYP
12 ganglioglioma 10.3 ENO2 SYP
13 hemangioblastoma 10.3 ENO2 SYP
14 ependymoma 10.3 ENO2 SYP
15 carotid body cancer 10.3 ENO2 SYP
16 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 SYP
17 adenosquamous lung carcinoma 10.3 ENO2 PDGFRA
18 auditory system cancer 10.3 ENO2 SYP
19 sinonasal undifferentiated carcinoma 10.3 ENO2 SYP
20 pancreatic somatostatinoma 10.3 ENO2 SYP
21 small cell carcinoma of the bladder 10.3 ENO2 SYP
22 papillary tumor of the pineal region 10.3 ENO2 SYP
23 sensory organ benign neoplasm 10.3 ENO2 SYP
24 middle ear adenoma 10.3 ENO2 SYP
25 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
26 atypical follicular adenoma 10.3 ENO2 SYP
27 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 SYP
28 cerebellum cancer 10.3 ENO2 SYP
29 supratentorial cancer 10.3 PDGFRA SYP
30 clear cell ependymoma 10.3 ENO2 SYP
31 rhabdoid cancer 10.3 ENO2 SYP
32 cerebrum cancer 10.3 PDGFRA SYP
33 cerebral neuroblastoma 10.3 ENO2 SYP
34 cauda equina neoplasm 10.3 ENO2 SYP
35 extraosseous chondrosarcoma 10.3 ENO2 SYP
36 subependymal glioma 10.3 ENO2 SYP
37 astroblastoma 10.3 ENO2 SYP
38 cerebral ventricle cancer 10.3 ENO2 SYP
39 olfactory nerve neoplasm 10.3 ENO2 SYP
40 tracheal cancer 10.3 AFP ENO2
41 pineal gland cancer 10.3 ENO2 SYP
42 germ cell and embryonal cancer 10.3 AFP ENO2
43 autonomic nervous system benign neoplasm 10.3 ENO2 SYP
44 melanotic neuroectodermal tumor 10.3 ENO2 SYP
45 benign ependymoma 10.3 ENO2 SYP
46 nodular ganglioneuroblastoma 10.3 ENO2 SYP
47 ganglioneuroblastoma 10.3 ENO2 SYP
48 pineocytoma 10.3 ENO2 SYP
49 desmoplastic small round cell tumor 10.2 ENO2 SYP
50 rhabdoid tumor predisposition syndrome 1 10.2 PTPRC SYP

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:



Diseases related to Endometrial Small Cell Carcinoma
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Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

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MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 AFP ENO2 KIT NCAM1 PDGFRA SYP
2 neoplasm MP:0002006 9.26 AFP KIT PDGFRA PTPRC
3 nervous system MP:0003631 9.1 ENO2 KIT NCAM1 PDGFRA PTPRC SYP
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Drugs & Therapeutics for Endometrial Small Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

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Genetic Tests for Endometrial Small Cell Carcinoma

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Anatomical Context for Endometrial Small Cell Carcinoma

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MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

42
Bone, Ovary, Pineal, Kidney, Colon, Testis, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrial Small Cell Carcinoma:

20
The Endometrium
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Publications for Endometrial Small Cell Carcinoma

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Articles related to Endometrial Small Cell Carcinoma:

# Title Authors Year
1
Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. ( 25400430 )
2014
2
Primary endometrial small cell carcinoma. ( 22185556 )
2012
3
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. ( 17606050 )
2007
4
Neuroendocrine differentiation in müllerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed müllerian tumor containing small-cell carcinoma. ( 3020961 )
1986
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Variations for Endometrial Small Cell Carcinoma

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Expression for Endometrial Small Cell Carcinoma

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Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.
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Pathways for Endometrial Small Cell Carcinoma

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Pathways related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.11 ENO2 NCAM1 SYP
2
NF-kappaB Signaling 4
12.06 KIT NCAM1 PTPRC
3
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.56 KIT NCAM1 PTPRC
4
Innate Lymphoid Cell Differentiation Pathways 66
11.34 KIT NCAM1 PTPRC
5
Central carbon metabolism in cancer 38
11.27 KIT PDGFRA
6
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.23 NCAM1 PDGFRA SYP
7
B Cell Development Pathways 66
11.16 KIT PTPRC
8
Dendritic Cells Developmental Lineage Pathway 66
11 KIT NCAM1 PTPRC
9
Cardiac Progenitor Differentiation 1
10.52 KIT NCAM1 PDGFRA
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GO Terms for Endometrial Small Cell Carcinoma

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Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 KIT NCAM1 PDGFRA PTPRC
2 cytoplasmic side of plasma membrane GO:0009898 9.16 KIT PTPRC
3 external side of plasma membrane GO:0009897 8.92 KIT NCAM1 PDGFRA PTPRC

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.43 KIT PDGFRA PTPRC
2 hematopoietic progenitor cell differentiation GO:0002244 9.4 PDGFRA PTPRC
3 T cell differentiation GO:0030217 9.37 KIT PTPRC
4 MAPK cascade GO:0000165 9.33 KIT NCAM1 PDGFRA
5 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.32 KIT PDGFRA
6 positive regulation of phospholipase C activity GO:0010863 8.96 KIT PDGFRA
7 positive regulation of MAPK cascade GO:0043410 8.8 KIT PDGFRA PTPRC

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.62 KIT PDGFRA
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Sources for Endometrial Small Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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