MCID: END013
MIFTS: 29

Endometrial Small Cell Carcinoma

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Endometrial Small Cell Carcinoma

MalaCards integrated aliases for Endometrial Small Cell Carcinoma:

Name: Endometrial Small Cell Carcinoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:7139
NCIt 50 C40155
UMLS 73 C1516858

Summaries for Endometrial Small Cell Carcinoma

MalaCards based summary : Endometrial Small Cell Carcinoma is related to small cell carcinoma and ureter small cell carcinoma. An important gene associated with Endometrial Small Cell Carcinoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include tongue, and related phenotypes are behavior/neurological and cellular

Related Diseases for Endometrial Small Cell Carcinoma

Diseases related to Endometrial Small Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 small cell carcinoma 28.7 ENO2 KIT NCAM1 PDGFRA PTPRC SYP
2 ureter small cell carcinoma 10.9 ENO2 SYP
3 urinary bladder small cell neuroendocrine carcinoma 10.9 ENO2 SYP
4 auditory system cancer 10.9 ENO2 SYP
5 sinonasal undifferentiated carcinoma 10.9 ENO2 SYP
6 pancreatic somatostatinoma 10.9 ENO2 SYP
7 small cell carcinoma of the bladder 10.8 ENO2 SYP
8 papillary tumor of the pineal region 10.8 ENO2 SYP
9 middle ear adenoma 10.8 ENO2 SYP
10 ovarian carcinosarcoma 10.8 ENO2 SYP
11 pulmonary large cell neuroendocrine carcinoma 10.8 ENO2 SYP
12 atypical follicular adenoma 10.8 ENO2 SYP
13 central nervous system primitive neuroectodermal neoplasm 10.8 ENO2 SYP
14 cerebellum cancer 10.8 ENO2 SYP
15 subependymal glioma 10.8 ENO2 SYP
16 olfactory nerve neoplasm 10.8 ENO2 SYP
17 cerebral neuroblastoma 10.8 ENO2 SYP
18 cauda equina neoplasm 10.8 ENO2 SYP
19 extraosseous chondrosarcoma 10.8 ENO2 SYP
20 benign ependymoma 10.8 ENO2 SYP
21 astroblastoma 10.8 ENO2 SYP
22 cerebral ventricle cancer 10.8 ENO2 SYP
23 cerebrum cancer 10.8 ENO2 SYP
24 pineal gland cancer 10.8 ENO2 SYP
25 melanotic neuroectodermal tumor 10.8 ENO2 SYP
26 nodular ganglioneuroblastoma 10.8 ENO2 SYP
27 primitive neuroectodermal tumor of the cervix uteri 10.8 ENO2 PTPRC
28 supratentorial cancer 10.8 ENO2 SYP
29 mucinous ovarian cystadenoma 10.8 ENO2 SYP
30 pineocytoma 10.8 ENO2 SYP
31 respiratory system benign neoplasm 10.8 ENO2 SYP
32 desmoplastic small round cell tumor 10.8 ENO2 SYP
33 carcinoid tumors, intestinal 10.8 ENO2 SYP
34 bone benign neoplasm 10.8 ENO2 SYP
35 kidney rhabdoid cancer 10.8 ENO2 PTPRC
36 multiple mucosal neuroma 10.8 ENO2 NCAM1
37 meningeal melanomatosis 10.8 ENO2 SYP
38 papillary ependymoma 10.8 ENO2 SYP
39 lung meningioma 10.8 ENO2 NCAM1
40 connective tissue benign neoplasm 10.8 ENO2 SYP
41 glomus tumor 10.7 ENO2 SYP
42 choriocarcinoma of ovary 10.7 ENO2 NCAM1
43 intraocular retinoblastoma 10.7 ENO2 SYP
44 esophageal neuroendocrine tumor 10.7 NCAM1 SYP
45 sclerosing hemangioma 10.7 ENO2 SYP
46 subependymal giant cell astrocytoma 10.7 ENO2 SYP
47 central neurocytoma 10.7 ENO2 SYP
48 ovarian large-cell neuroendocrine carcinoma 10.7 NCAM1 SYP
49 lung combined type small cell carcinoma 10.7 NCAM1 SYP
50 carcinoid syndrome 10.7 ENO2 SYP

Graphical network of the top 20 diseases related to Endometrial Small Cell Carcinoma:



Diseases related to Endometrial Small Cell Carcinoma

Symptoms & Phenotypes for Endometrial Small Cell Carcinoma

MGI Mouse Phenotypes related to Endometrial Small Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 PDGFRA AFP ENO2 SYP F2 KIT
2 cellular MP:0005384 9.87 NCAM1 PDGFRA PTPRC ENO2 SMUG1 UBC
3 mortality/aging MP:0010768 9.86 PDGFRA PTPRC AFP SMUG1 F2 UBC
4 neoplasm MP:0002006 9.55 PDGFRA PTPRC AFP SMUG1 KIT
5 nervous system MP:0003631 9.5 NCAM1 PDGFRA PTPRC ENO2 SYP F2
6 respiratory system MP:0005388 9.02 PDGFRA PTPRC ENO2 F2 KIT

Drugs & Therapeutics for Endometrial Small Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrial Small Cell Carcinoma

Genetic Tests for Endometrial Small Cell Carcinoma

Anatomical Context for Endometrial Small Cell Carcinoma

MalaCards organs/tissues related to Endometrial Small Cell Carcinoma:

41
Tongue

Publications for Endometrial Small Cell Carcinoma

Articles related to Endometrial Small Cell Carcinoma:

# Title Authors Year
1
Value of (18)F-FDG PET/CT and MRI in diagnosing primary endometrial small cell carcinoma. ( 25400430 )
2014
2
Primary endometrial small cell carcinoma. ( 22185556 )
2012
3
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma. ( 17606050 )
2007
4
Neuroendocrine differentiation in mA1llerian neoplasms. An immunohistochemical study of a "pure" endometrial small-cell carcinoma and a mixed mA1llerian tumor containing small-cell carcinoma. ( 3020961 )
1986

Variations for Endometrial Small Cell Carcinoma

Expression for Endometrial Small Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Small Cell Carcinoma.

Pathways for Endometrial Small Cell Carcinoma

GO Terms for Endometrial Small Cell Carcinoma

Cellular components related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 KIT NCAM1 PDGFRA PTPRC
2 external side of plasma membrane GO:0009897 9.02 F2 KIT NCAM1 PDGFRA PTPRC

Biological processes related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 AFP F2 UBC
2 T cell differentiation GO:0030217 9.43 KIT PTPRC
3 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 KIT PDGFRA
4 positive regulation of JAK-STAT cascade GO:0046427 9.32 F2 KIT
5 negative regulation of platelet activation GO:0010544 9.26 F2 PDGFRA
6 MAPK cascade GO:0000165 9.26 KIT NCAM1 PDGFRA UBC
7 positive regulation of phospholipase C activity GO:0010863 9.16 KIT PDGFRA
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 F2 KIT PDGFRA

Molecular functions related to Endometrial Small Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.8 KIT NCAM1 PDGFRA

Sources for Endometrial Small Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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