MCID: END025
MIFTS: 32

Endometrial Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Squamous Cell Carcinoma

MalaCards integrated aliases for Endometrial Squamous Cell Carcinoma:

Name: Endometrial Squamous Cell Carcinoma 12 15 17 71
Squamous Cell Carcinoma of Endometrium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5533
NCIt 49 C8719
UMLS 71 C1333396

Summaries for Endometrial Squamous Cell Carcinoma

Disease Ontology : 12 An endometrial carcinoma that has material basis in squamous cells.

MalaCards based summary : Endometrial Squamous Cell Carcinoma, also known as squamous cell carcinoma of endometrium, is related to in situ carcinoma and squamous cell carcinoma of the corpus uteri. An important gene associated with Endometrial Squamous Cell Carcinoma is NUAK1 (NUAK Family Kinase 1), and among its related pathways/superpathways are Gastric cancer and Glioblastoma Multiforme. Affiliated tissues include breast, ovary and cervix, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Endometrial Squamous Cell Carcinoma

Diseases related to Endometrial Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 41)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.1 PGR CDKN2A
2 squamous cell carcinoma of the corpus uteri 12.0
3 squamous cell carcinoma 10.5
4 vaginal discharge 10.1
5 vagina leiomyoma 10.1 PGR CDKN2A
6 ovarian seromucinous carcinoma 10.1 PGR CDKN2A
7 endometrial mucinous adenocarcinoma 10.1 PGR CDKN2A
8 mucinous adenocarcinoma 10.0 PGR CDKN2A
9 vaginal benign neoplasm 10.0 PGR CDKN2A
10 vulvar leiomyoma 10.0 PGR CDKN2A
11 cervical mucinous adenocarcinoma 10.0 PGR CDKN2A
12 vaginal cancer 10.0 PGR CDKN2A
13 vulvar disease 10.0 PGR CDKN2A
14 endocervical carcinoma 10.0 PGR CDKN2A
15 perivascular epithelioid cell tumor 10.0 PGR CDKN2A
16 ichthyosis 10.0
17 endocervical adenocarcinoma 10.0 PGR CDKN2A
18 peritoneal mesothelioma 10.0 PGR CDKN2A
19 bilateral breast cancer 10.0 PGR CDKN2A
20 tonsil cancer 10.0 PGR CDKN2A
21 uterine corpus cancer 10.0 PGR CDKN2A
22 oropharynx cancer 10.0 PGR CDKN2A
23 endometrial cancer 10.0
24 umbilical hernia 10.0
25 leiomyoma 10.0
26 rare tumor 10.0
27 pre-malignant neoplasm 10.0 PGR CDKN2A
28 endometrial adenocarcinoma 10.0 PGR CDKN2A
29 sporadic breast cancer 10.0 PGR CDKN2A
30 ovary adenocarcinoma 9.9 PGR CDKN2A
31 leiomyosarcoma 9.9 PGR CDKN2A
32 ductal carcinoma in situ 9.9 PGR CDKN2A
33 malignant ovarian surface epithelial-stromal neoplasm 9.9 PGR CDKN2A
34 ovary epithelial cancer 9.9 PGR CDKN2A
35 cell type benign neoplasm 9.8 PGR CDKN2A
36 verrucous carcinoma 9.8 CDKN2A CDK6
37 ovarian serous cystadenocarcinoma 9.7 PGR CDKN2A
38 retinal cancer 9.7 CDKN2A CDK6
39 uterine carcinosarcoma 9.7 PGR CDKN2A
40 liposarcoma 9.6 CDKN2A CDK6
41 ocular cancer 9.3 CDKN2A CDK6

Graphical network of the top 20 diseases related to Endometrial Squamous Cell Carcinoma:



Diseases related to Endometrial Squamous Cell Carcinoma

Symptoms & Phenotypes for Endometrial Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.4 CDK6 CDKN2A STRADA
2 Decreased viability GR00221-A-2 10.4 CDK6 STRADA
3 Decreased viability GR00221-A-3 10.4 CDKN2A STRADA
4 Decreased viability GR00221-A-4 10.4 CDK6 CDKN2A STRADA
5 Decreased viability GR00301-A 10.4 CDK6
6 Decreased viability GR00402-S-2 10.4 CDK6 CDKN2A STRADA
7 Decreased substrate adherent cell growth GR00193-A-1 9.72 CDK6 NUAK1 STRADA
8 Decreased substrate adherent cell growth GR00193-A-2 9.72 CDK6
9 Decreased substrate adherent cell growth GR00193-A-3 9.72 STRADA
10 Decreased viability after gemcitabine stimulation GR00107-A-2 9.16 CDK6 CDKN2A
11 Increased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.13 CDK6 NUAK1 STRADA
12 Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation GR00016-A 8.8 CDK6 NUAK1 STRADA

MGI Mouse Phenotypes related to Endometrial Squamous Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 CDK6 CDKN2A NUAK1 PGR

Drugs & Therapeutics for Endometrial Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrial Squamous Cell Carcinoma

Genetic Tests for Endometrial Squamous Cell Carcinoma

Anatomical Context for Endometrial Squamous Cell Carcinoma

MalaCards organs/tissues related to Endometrial Squamous Cell Carcinoma:

40
Breast, Ovary, Cervix, Tonsil

Publications for Endometrial Squamous Cell Carcinoma

Articles related to Endometrial Squamous Cell Carcinoma:

(show all 34)
# Title Authors PMID Year
1
Chronic uterine inversion with malignancy mimicking carcinoma cervix. 61
30709891 2019
2
Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report. 61
30508948 2018
3
Primary squamous cell carcinoma of the endometrium in a woman of reproductive age: a rare case report. 61
29865971 2018
4
Primary squamous cell carcinoma of endometrium: case report and literature review. 61
30574227 2018
5
Primary squamous cell carcinoma of endometrium: case report and literature review. 61
30123411 2018
6
Primary Endometrial Squamous Cell Carcinoma in-situ with Extensive Icthyosis Uteri: A Rare Case Report. 61
28969146 2017
7
S100P is Overexpressed in Squamous Cell and Adenosquamous Carcinoma Subtypes of Endometrial Cancer and Promotes Cancer Cell Proliferation and Invasion. 61
27918216 2016
8
Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease. 61
26629388 2015
9
Primary squamous cell carcinoma of endometrium: clinicopathologic analysis of two cases with review of the literature. 61
24020148 2013
10
Sister Mary Joseph's nodule associated with rare endometrial squamous cell carcinoma. 61
22562383 2012
11
Primary endometrial squamous cell carcinoma: a case report and review of relevant literature on korean women. 61
23110036 2012
12
Primary squamous cell carcinoma of the endometrium: a case report. 61
21797134 2011
13
Primary endometrial squamous cell carcinoma. 61
18236059 2008
14
Primary endometrial squamous cell carcinoma with extensive squamous metaplasia and dysplasia. 61
18603705 2008
15
Does "ichthyosis uteri" have malignant potential? A case report of squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri. 61
18234121 2008
16
p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium. 61
16844559 2006
17
Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion. 61
16529798 2006
18
Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. 61
15599594 2005
19
Primary squamous cell carcinoma of endometrium: a case report. 61
15755014 2005
20
Low grade uterine stromal sarcoma and squamous cell carcinoma associated with an IUD: a report of 2 cases. 61
15134161 2004
21
Primary squamous cell carcinoma of the endometrium: a case report. 61
15022928 2003
22
Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervix. 61
15206720 2003
23
Five-year survival of a patient with primary endometrial squamous cell carcinoma: a case report and review of the literature. 61
12214735 2002
24
Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. 61
11719459 2001
25
Squamous cell carcinoma of the endometrium: a report of eight cases and a review of the literature. 61
8626118 1996
26
Endometrial squamous cell carcinoma following whole pelvic radiation therapy: response to carboplatin. 61
7774850 1995
27
Primary squamous cell carcinoma of the endometrium: a case report and a suggestion of new histogenesis. 61
7883431 1995
28
Primary endometrial squamous cell carcinoma with long-term survival. 61
7508224 1993
29
Squamous cell carcinoma of the endometrium. A case report. 61
1538370 1992
30
Squamous-cell carcinoma of the endometrium and cervix. 61
1680092 1991
31
Endometrial squamous cell carcinoma. 61
1785281 1991
32
Endometrial squamous cell carcinoma: report of three cases and review of the literature. 61
2180795 1990
33
Primary squamous cell carcinoma with its spindle cell variant in the endometrium. A case report and review of literature. 61
3942966 1986
34
Primary squamous cell carcinoma of endometrium.--Report of a case and review of literature. 61
7228217 1980

Variations for Endometrial Squamous Cell Carcinoma

Cosmic variations for Endometrial Squamous Cell Carcinoma:

9 (show all 43)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM96842299 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.388C>G p.R130G 10:87933147-87933147 3
2 COSM96843054 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.697C>T p.R233* 10:87957915-87957915 3
3 COSM96872458 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.646G>A p.V216M 10:87957864-87957864 3
4 COSM96842497 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.388C>T p.R130* 10:87933147-87933147 3
5 COSM150913673 CTNNB1 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
6 COSM151812133 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
7 COSM151558632 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
8 COSM151591483 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
9 COSM102378420 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
10 COSM150309931 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
11 COSM150868072 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
12 COSM150733759 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
13 COSM111036336 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
14 COSM151307719 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
15 COSM151343569 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
16 COSM149584980 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
17 COSM151748805 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
18 COSM149480628 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
19 COSM151491567 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
20 COSM151326005 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
21 COSM110179399 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
22 COSM151827099 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
23 COSM150814237 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
24 COSM149957688 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
25 COSM105888125 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
26 COSM150275008 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
27 COSM150452511 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
28 COSM89368376 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
29 COSM150659544 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
30 COSM111887048 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
31 COSM109691918 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
32 COSM149290602 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
33 COSM151979834 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
34 COSM146867744 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
35 COSM149384041 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
36 COSM111893701 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
37 COSM150526277 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
38 COSM150961141 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
39 COSM150142107 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
40 COSM146243262 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
41 COSM102450692 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3
42 COSM150088665 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3
43 COSM151345096 endometrium,NS,carcinoma,squamous cell carcinoma c.73G>T p.D25Y 3:41224606-41224606 3

Expression for Endometrial Squamous Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Squamous Cell Carcinoma.

Pathways for Endometrial Squamous Cell Carcinoma

Pathways related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 PGR CDKN2A CDK6
2 11.3 CDKN2A CDK6
3
Show member pathways
11.04 PGR CDKN2A CDK6
4 10.46 CDKN2A CDK6

GO Terms for Endometrial Squamous Cell Carcinoma

Cellular components related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.43 STRADA PGR NUAK1 DTL CDKN2A CDK6
2 nucleoplasm GO:0005654 9.1 STRADA PGR NUAK1 DTL CDKN2A CDK6

Biological processes related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.43 STRADA NUAK1 CDK6
2 G1/S transition of mitotic cell cycle GO:0000082 9.16 CDKN2A CDK6
3 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 8.96 CDKN2A CDK6
4 cell cycle arrest GO:0007050 8.8 STRADA CDKN2A CDK6

Molecular functions related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.13 STRADA NUAK1 CDK6
2 protein serine/threonine kinase activity GO:0004674 8.8 STRADA NUAK1 CDK6

Sources for Endometrial Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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