MCID: END025
MIFTS: 36

Endometrial Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Squamous Cell Carcinoma

MalaCards integrated aliases for Endometrial Squamous Cell Carcinoma:

Name: Endometrial Squamous Cell Carcinoma 12 15 17 72
Squamous Cell Carcinoma of Endometrium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5533
NCIt 50 C8719
UMLS 72 C1333396

Summaries for Endometrial Squamous Cell Carcinoma

Disease Ontology : 12 An endometrial carcinoma that has material basis in squamous cells.

MalaCards based summary : Endometrial Squamous Cell Carcinoma, also known as squamous cell carcinoma of endometrium, is related to in situ carcinoma and endometrial cancer. An important gene associated with Endometrial Squamous Cell Carcinoma is CDK6 (Cyclin Dependent Kinase 6), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Focal Adhesion. Affiliated tissues include cervix, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Endometrial Squamous Cell Carcinoma

Diseases related to Endometrial Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 29.7 PGR ESR1 CDKN2A
2 endometrial cancer 27.5 PGR ESR1 CDKN2A CDK6 CCND1 AR
3 squamous cell carcinoma of the corpus uteri 12.0
4 squamous cell carcinoma 10.5
5 deafness, autosomal recessive 39 10.5 MET HGF
6 deafness, autosomal recessive 97 10.5 MET HGF
7 large cell medulloblastoma 10.4 MET HGF
8 doxorubicin induced cardiomyopathy 10.4 MET HGF
9 corneal abscess 10.4 PGR AR
10 vulvar dystrophy 10.4 PGR CDKN2A
11 papillary hidradenoma 10.4 PGR AR
12 bizarre leiomyoma 10.4 PGR CDKN2A
13 familial renal papillary carcinoma 10.4 MET HGF
14 papillary thyroid microcarcinoma 10.3 MET HGF
15 spindle cell synovial sarcoma 10.3 MET HGF
16 acral lentiginous melanoma 10.3 MET CDKN2A
17 spinal chordoma 10.3 MET HGF
18 vulvar sarcoma 10.2 TCHP AR
19 acute kidney tubular necrosis 10.2 HGF CDKN2A
20 leiomyomatosis 10.1 PGR ESR1
21 breast papillomatosis 10.1 CDKN2A CCND1
22 vaginal discharge 10.1
23 bartholin's gland adenoma 10.1 PGR ESR1
24 vestibular gland benign neoplasm 10.1 PGR ESR1
25 lung leiomyoma 10.1 PGR ESR1
26 tonsil squamous cell carcinoma 10.1 CDKN2A CCND1
27 vulvar syringoma 10.1 PGR ESR1
28 glassy cell carcinoma of the cervix 10.1 PGR ESR1
29 bowenoid papulosis 10.1 CDKN2A CCND1
30 skin carcinoma in situ 10.1 CDKN2A CCND1
31 vulvar leiomyoma 10.1 PGR ESR1
32 trigonitis 10.1 PGR ESR1
33 vulvar benign neoplasm 10.1 PGR ESR1
34 central nervous system melanocytic neoplasm 10.1 HGF CDKN2A
35 predominantly cortical thymoma 10.1 PGR ESR1
36 breast scirrhous carcinoma 10.1 PGR ESR1
37 breast medullary carcinoma 10.1 PGR ESR1
38 progesterone-receptor positive breast cancer 10.1 PGR ESR1
39 cribriform carcinoma 10.1 PGR ESR1
40 progesterone resistance 10.1 PGR ESR1
41 oral leukoplakia 10.1 CDKN2A CCND1
42 ischemic fasciitis 10.1 CDKN2A CCND1
43 deep angioma 10.1 PGR ESR1
44 cervical carcinosarcoma 10.1 PGR ESR1
45 female reproductive endometrioid cancer 10.1 PGR ESR1
46 intramuscular hemangioma 10.1 PGR ESR1
47 estrogen excess 10.1 PGR ESR1
48 cervical clear cell adenocarcinoma 10.1 PGR ESR1
49 mammographic density 10.1 PGR ESR1
50 inflammatory breast carcinoma 10.0 PGR ESR1

Graphical network of the top 20 diseases related to Endometrial Squamous Cell Carcinoma:



Diseases related to Endometrial Squamous Cell Carcinoma

Symptoms & Phenotypes for Endometrial Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.19 CDK6 CDKN2A ESR1 HGF
2 Decreased viability GR00221-A-2 10.19 CDK6 ESR1 HGF
3 Decreased viability GR00221-A-3 10.19 CDKN2A
4 Decreased viability GR00221-A-4 10.19 CDK6 CDKN2A ESR1 HGF
5 Decreased viability GR00301-A 10.19 CDK6
6 Decreased viability GR00402-S-2 10.19 CDK6 CDKN2A ESR1 HGF
7 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 8.62 CDK6 MET

MGI Mouse Phenotypes related to Endometrial Squamous Cell Carcinoma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.14 AR CCND1 CDK6 CDKN2A ESR1 HGF
2 cellular MP:0005384 10.13 AR CCND1 CDK6 CDKN2A ESR1 HGF
3 embryo MP:0005380 10.04 AR CDK6 CDKN2A ESR1 HGF MET
4 endocrine/exocrine gland MP:0005379 10.02 AR CCND1 CDK6 CDKN2A ESR1 MET
5 growth/size/body region MP:0005378 10 AR CCND1 CDK6 CDKN2A ESR1 HGF
6 hematopoietic system MP:0005397 9.98 AR CCND1 CDK6 CDKN2A ESR1 HGF
7 immune system MP:0005387 9.95 AR CCND1 CDK6 CDKN2A ESR1 MET
8 mortality/aging MP:0010768 9.92 AR CCND1 CDK6 CDKN2A ESR1 HGF
9 digestive/alimentary MP:0005381 9.91 AR CCND1 CDKN2A ESR1 MET
10 liver/biliary system MP:0005370 9.85 AR CDK6 CDKN2A ESR1 HGF MET
11 muscle MP:0005369 9.73 AR CDK6 CDKN2A ESR1 MET PGR
12 neoplasm MP:0002006 9.7 AR CCND1 CDK6 CDKN2A ESR1 MET
13 no phenotypic analysis MP:0003012 9.35 CDKN2A ESR1 HGF MET PGR
14 reproductive system MP:0005389 9.1 AR CCND1 CDK6 CDKN2A ESR1 PGR

Drugs & Therapeutics for Endometrial Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrial Squamous Cell Carcinoma

Genetic Tests for Endometrial Squamous Cell Carcinoma

Anatomical Context for Endometrial Squamous Cell Carcinoma

MalaCards organs/tissues related to Endometrial Squamous Cell Carcinoma:

41
Cervix

Publications for Endometrial Squamous Cell Carcinoma

Articles related to Endometrial Squamous Cell Carcinoma:

(show all 34)
# Title Authors PMID Year
1
Chronic uterine inversion with malignancy mimicking carcinoma cervix. 38
30709891 2019
2
Primary squamous cell carcinoma of the endometrium in a woman of perimenopausal age: A case report. 38
30508948 2018
3
Primary squamous cell carcinoma of the endometrium in a woman of reproductive age: a rare case report. 38
29865971 2018
4
Primary squamous cell carcinoma of endometrium: case report and literature review. 38
30574227 2018
5
Primary squamous cell carcinoma of endometrium: case report and literature review. 38
30123411 2018
6
Primary Endometrial Squamous Cell Carcinoma in-situ with Extensive Icthyosis Uteri: A Rare Case Report. 38
28969146 2017
7
S100P is Overexpressed in Squamous Cell and Adenosquamous Carcinoma Subtypes of Endometrial Cancer and Promotes Cancer Cell Proliferation and Invasion. 38
27918216 2016
8
Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease. 38
26629388 2015
9
Primary squamous cell carcinoma of endometrium: clinicopathologic analysis of two cases with review of the literature. 38
24020148 2013
10
Sister Mary Joseph's nodule associated with rare endometrial squamous cell carcinoma. 38
22562383 2012
11
Primary endometrial squamous cell carcinoma: a case report and review of relevant literature on korean women. 38
23110036 2012
12
Primary squamous cell carcinoma of the endometrium: a case report. 38
21797134 2011
13
Primary endometrial squamous cell carcinoma. 38
18236059 2008
14
Primary endometrial squamous cell carcinoma with extensive squamous metaplasia and dysplasia. 38
18603705 2008
15
Does "ichthyosis uteri" have malignant potential? A case report of squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri. 38
18234121 2008
16
p16, p14, p53, cyclin D1, and steroid hormone receptor expression and human papillomaviruses analysis in primary squamous cell carcinoma of the endometrium. 38
16844559 2006
17
Verrucous carcinoma of the endometrium: case history, pathologic findings, brief review of literature and discussion. 38
16529798 2006
18
Expression of COX-2 and HER-2/neu and estrogen and progesterone receptor in primary squamous cell carcinomas of the endometrium. 38
15599594 2005
19
Primary squamous cell carcinoma of endometrium: a case report. 38
15755014 2005
20
Low grade uterine stromal sarcoma and squamous cell carcinoma associated with an IUD: a report of 2 cases. 38
15134161 2004
21
Primary squamous cell carcinoma of the endometrium: a case report. 38
15022928 2003
22
Expression of indoleamine 2,3-dioxygenase in carcinoma of human endometrium and uterine cervix. 38
15206720 2003
23
Five-year survival of a patient with primary endometrial squamous cell carcinoma: a case report and review of the literature. 38
12214735 2002
24
Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. 38
11719459 2001
25
Squamous cell carcinoma of the endometrium: a report of eight cases and a review of the literature. 38
8626118 1996
26
Endometrial squamous cell carcinoma following whole pelvic radiation therapy: response to carboplatin. 38
7774850 1995
27
Primary squamous cell carcinoma of the endometrium: a case report and a suggestion of new histogenesis. 38
7883431 1995
28
Primary endometrial squamous cell carcinoma with long-term survival. 38
7508224 1993
29
Squamous cell carcinoma of the endometrium. A case report. 38
1538370 1992
30
Squamous-cell carcinoma of the endometrium and cervix. 38
1680092 1991
31
Endometrial squamous cell carcinoma. 38
1785281 1991
32
Endometrial squamous cell carcinoma: report of three cases and review of the literature. 38
2180795 1990
33
Primary squamous cell carcinoma with its spindle cell variant in the endometrium. A case report and review of literature. 38
3942966 1986
34
Primary squamous cell carcinoma of endometrium.--Report of a case and review of literature. 38
7228217 1980

Variations for Endometrial Squamous Cell Carcinoma

Cosmic variations for Endometrial Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM5035 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.646G>A p.V216M 10:87957864-87957864 3
2 COSM5152 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.388C>T p.R130* 10:87933147-87933147 3
3 COSM5219 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.388C>G p.R130G 10:87933147-87933147 3
4 COSM5154 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.697C>T p.R233* 10:87957915-87957915 3
5 COSM5661 CTNNB1 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 3

Expression for Endometrial Squamous Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Squamous Cell Carcinoma.

Pathways for Endometrial Squamous Cell Carcinoma

Pathways related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 MET HGF CDK6 CCND1
2
Show member pathways
12.62 MET HGF CDK6 CCND1
3
Show member pathways
12.57 CDKN2A CDK6 CCND1 AR
4
Show member pathways
12.37 MET HGF CCND1
5
Show member pathways
12.33 MET HGF ESR1 CDKN2A CDK6 CCND1
6 12.22 MET HGF ESR1 CDKN2A CDK6 CCND1
7 12.2 MET CDKN2A CDK6 CCND1
8
Show member pathways
12.16 CDKN2A CDK6 CCND1
9 12.13 CDKN2A CDK6 CCND1
10
Show member pathways
12.1 CDKN2A CDK6 CCND1
11 12.04 CDKN2A CDK6 CCND1
12 11.93 MET HGF ESR1 CCND1
13 11.89 CDKN2A CDK6 CCND1
14 11.86 ESR1 CCND1 AR
15
Show member pathways
11.83 PGR MET HGF ESR1 CDKN2A CDK6
16
Show member pathways
11.8 PGR ESR1 CDKN2A CDK6 CCND1
17 11.68 CDKN2A CDK6 CCND1
18
Show member pathways
11.56 PGR ESR1 AR
19 11.3 CDK6 CCND1 AR
20
Show member pathways
11.26 MET HGF
21 11.23 MET HGF
22 11.19 ESR1 CCND1
23 11.15 MET HGF
24 11.1 CDKN2A CDK6
25 11.09 CDK6 CCND1
26 11.04 MET HGF
27 10.9 ESR1 CCND1
28 10.71 MET HGF

GO Terms for Endometrial Squamous Cell Carcinoma

Cellular components related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CDK6 CCND1

Biological processes related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.73 PGR MET HGF ESR1 CDKN2A AR
2 positive regulation of protein kinase B signaling GO:0051897 9.67 MET HGF ESR1
3 G1/S transition of mitotic cell cycle GO:0000082 9.61 CDKN2A CDK6 CCND1
4 liver development GO:0001889 9.58 MET HGF CCND1
5 intracellular receptor signaling pathway GO:0030522 9.52 ESR1 AR
6 transcription, DNA-templated GO:0006351 9.51 ESR1 AR
7 steroid hormone mediated signaling pathway GO:0043401 9.5 PGR ESR1 AR
8 hepatocyte growth factor receptor signaling pathway GO:0048012 9.48 MET HGF
9 Leydig cell differentiation GO:0033327 9.46 CCND1 AR
10 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.37 MET HGF
11 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 PGR ESR1 CCND1 AR
12 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 PGR AR
13 mammary gland alveolus development GO:0060749 8.8 ESR1 CCND1 AR

Molecular functions related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.67 PGR ESR1 CCND1 AR
2 transcription factor binding GO:0008134 9.62 ESR1 CDKN2A CCND1 AR
3 ATPase binding GO:0051117 9.43 PGR ESR1 AR
4 steroid hormone receptor activity GO:0003707 9.33 PGR ESR1 AR
5 nuclear receptor activity GO:0004879 9.13 PGR ESR1 AR
6 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.1 CDK6
7 steroid binding GO:0005496 8.8 PGR ESR1 AR

Sources for Endometrial Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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