MCID: END025
MIFTS: 38

Endometrial Squamous Cell Carcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Squamous Cell Carcinoma

MalaCards integrated aliases for Endometrial Squamous Cell Carcinoma:

Name: Endometrial Squamous Cell Carcinoma 12 15 73
Squamous Cell Carcinoma of Endometrium 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5533
NCIt 50 C8719
UMLS 73 C1333396

Summaries for Endometrial Squamous Cell Carcinoma

Disease Ontology : 12 An endometrial carcinoma that has_material_basis in squamous cells.

MalaCards based summary : Endometrial Squamous Cell Carcinoma, also known as squamous cell carcinoma of endometrium, is related to in situ carcinoma and squamous cell carcinoma of the corpus uteri. An important gene associated with Endometrial Squamous Cell Carcinoma is CDK6 (Cyclin Dependent Kinase 6), and among its related pathways/superpathways are ERK Signaling and PI3K-Akt signaling pathway. The drugs Nintedanib and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and colon, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Endometrial Squamous Cell Carcinoma

Diseases related to Endometrial Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.0 CDKN2A ESR1 PGR
2 squamous cell carcinoma of the corpus uteri 11.8
3 squamous cell carcinoma 10.5
4 leiomyomatosis 10.2 ESR1 PGR
5 vestibular gland benign neoplasm 10.2 ESR1 PGR
6 bartholin's gland adenoma 10.2 ESR1 PGR
7 vulvar syringoma 10.2 ESR1 PGR
8 glassy cell carcinoma of the cervix 10.2 ESR1 PGR
9 lung leiomyoma 10.2 ESR1 PGR
10 vulvar benign neoplasm 10.2 ESR1 PGR
11 trigonitis 10.2 ESR1 PGR
12 vulvar leiomyoma 10.2 ESR1 PGR
13 predominantly cortical thymoma 10.2 ESR1 PGR
14 breast medullary carcinoma 10.2 ESR1 PGR
15 breast scirrhous carcinoma 10.2 ESR1 PGR
16 progesterone-receptor positive breast cancer 10.2 ESR1 PGR
17 progesterone resistance 10.2 ESR1 PGR
18 cribriform carcinoma 10.2 ESR1 PGR
19 deep angioma 10.2 ESR1 PGR
20 female reproductive endometrioid cancer 10.2 ESR1 PGR
21 cervical carcinosarcoma 10.2 ESR1 PGR
22 estrogen excess 10.2 ESR1 PGR
23 intramuscular hemangioma 10.2 ESR1 PGR
24 mammographic density 10.2 ESR1 PGR
25 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
26 retinitis pigmentosa 47 10.2 ESR1 PGR
27 inflammatory breast carcinoma 10.2 ESR1 PGR
28 retinitis pigmentosa 20 10.2 ESR1 PGR
29 adenosarcoma 10.2 ESR1 PGR
30 luminal breast carcinoma 10.2 ESR1 PGR
31 endometriosis of ovary 10.2 ESR1 PGR
32 breast benign neoplasm 10.2 ESR1 PGR
33 thoracic benign neoplasm 10.2 ESR1 PGR
34 uterine corpus cancer 10.2 ESR1 PGR
35 lipid-rich carcinoma 10.2 ESR1 PGR
36 smooth muscle tumor 10.1 ESR1 PGR
37 uterine benign neoplasm 10.1 ESR1 PGR
38 endometritis 10.1 ESR1 PGR
39 mammary paget's disease 10.1 ESR1 PGR
40 tubular adenocarcinoma 10.1 ESR1 PGR
41 reproductive organ benign neoplasm 10.1 ESR1 PGR
42 fallopian tube carcinoma 10.1 ESR1 PGR
43 juvenile nasopharyngeal angiofibroma 10.1 ESR1 PGR
44 deafness, autosomal recessive 39 10.1 HGF MET
45 deafness, autosomal recessive 97 10.1 HGF MET
46 large cell medulloblastoma 10.1 HGF MET
47 doxorubicin induced cardiomyopathy 10.1 HGF MET
48 corneal abscess 10.1 AR PGR
49 angiomyolipoma 10.1 ESR1 PGR
50 postmenopausal atrophic vaginitis 10.1 AR ESR1

Graphical network of the top 20 diseases related to Endometrial Squamous Cell Carcinoma:



Diseases related to Endometrial Squamous Cell Carcinoma

Symptoms & Phenotypes for Endometrial Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.19 CDK6 CDKN2A ESR1 HGF
2 Decreased viability GR00221-A-2 10.19 CDK6 ESR1 HGF
3 Decreased viability GR00221-A-3 10.19 CDKN2A
4 Decreased viability GR00221-A-4 10.19 CDK6 CDKN2A ESR1 HGF
5 Decreased viability GR00301-A 10.19 CDK6
6 Decreased viability GR00402-S-2 10.19 CDK6 CDKN2A ESR1 HGF
7 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 8.62 CDK6 MET

MGI Mouse Phenotypes related to Endometrial Squamous Cell Carcinoma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 AR CCND1 CDK6 CDKN2A ESR1 HGF
2 cellular MP:0005384 10.14 AR CCND1 CDK6 CDKN2A ESR1 HGF
3 embryo MP:0005380 10.05 AR CDK6 CDKN2A ESR1 HGF MET
4 endocrine/exocrine gland MP:0005379 10.04 AR CCND1 CDK6 CDKN2A ESR1 MET
5 growth/size/body region MP:0005378 10.02 AR CCND1 CDK6 CDKN2A ESR1 HGF
6 hematopoietic system MP:0005397 10 AR CCND1 CDK6 CDKN2A ESR1 HGF
7 immune system MP:0005387 9.98 AR CCND1 CDK6 CDKN2A ESR1 MET
8 digestive/alimentary MP:0005381 9.92 AR CCND1 CDKN2A ESR1 MET
9 mortality/aging MP:0010768 9.92 AR CCND1 CDK6 CDKN2A ESR1 HGF
10 liver/biliary system MP:0005370 9.85 AR CDK6 CDKN2A ESR1 HGF MET
11 integument MP:0010771 9.8 AR CCND1 CDKN2A ESR1 PGR
12 muscle MP:0005369 9.73 AR CDK6 CDKN2A ESR1 MET PGR
13 neoplasm MP:0002006 9.7 AR CCND1 CDK6 CDKN2A ESR1 MET
14 no phenotypic analysis MP:0003012 9.35 CDKN2A ESR1 HGF MET PGR
15 reproductive system MP:0005389 9.1 AR CCND1 CDK6 CDKN2A ESR1 PGR

Drugs & Therapeutics for Endometrial Squamous Cell Carcinoma

Drugs for Endometrial Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nintedanib Approved Phase 2 656247-17-5 56843413
2 tyrosine Phase 2
3 Immunologic Factors Phase 2,Phase 1
4 Antibodies Phase 2,Phase 1
5 Immunoglobulins Phase 2,Phase 1
6 Immunoglobulin Fc Fragments Phase 2
7 Mitogens Phase 2,Phase 1
8
Dasatinib Approved, Investigational Phase 1 302962-49-8 3062316
9
Carboplatin Approved Phase 1 41575-94-4 10339178 38904 498142
10
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
11
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
12
Lenograstim Approved, Investigational Phase 1 135968-09-1
13
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
14
Bevacizumab Approved, Investigational Phase 1 216974-75-3
15
Doxil Approved June 1999 Phase 1 31703
16 Antineoplastic Agents, Phytogenic Phase 1
17 Protein Kinase Inhibitors Phase 1
18 Antimitotic Agents Phase 1
19 Albumin-Bound Paclitaxel Phase 1
20 Antibiotics, Antitubercular Phase 1
21 Adjuvants, Immunologic Phase 1
22 Topoisomerase Inhibitors Phase 1
23 Anti-Bacterial Agents Phase 1
24 Angiogenesis Modulating Agents Phase 1
25 Endothelial Growth Factors Phase 1
26 Immunoglobulin G Phase 1
27 Antibodies, Monoclonal Phase 1
28 Angiogenesis Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nintedanib in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01225887 Phase 2 Nintedanib
2 Dalantercept in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT01642082 Phase 2
3 Brivanib Alaninate in Treating Patients With Recurrent or Persistent Endometrial Cancer Completed NCT00888173 Phase 2 Brivanib Alaninate
4 Dasatinib, Paclitaxel, and Carboplatin in Treating Patients With Stage III-IV or Recurrent Endometrial Cancer Completed NCT01440998 Phase 1 Carboplatin;Dasatinib;Paclitaxel
5 Intraperitoneal Paclitaxel, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Stage III-IV Endometrial Cancer Completed NCT00575952 Phase 1 Cisplatin;Doxorubicin Hydrochloride;Paclitaxel
6 Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Bevacizumab in Treating Patients With Stage IV Melanoma That Cannot Be Removed by Surgery or Gynecological Cancers Recruiting NCT02020707 Phase 1 Paclitaxel Albumin-Stabilized Nanoparticle Formulation

Search NIH Clinical Center for Endometrial Squamous Cell Carcinoma

Genetic Tests for Endometrial Squamous Cell Carcinoma

Anatomical Context for Endometrial Squamous Cell Carcinoma

MalaCards organs/tissues related to Endometrial Squamous Cell Carcinoma:

41
Lung, Bone, Colon, Breast, Ovary, Cervix, Smooth Muscle

Publications for Endometrial Squamous Cell Carcinoma

Articles related to Endometrial Squamous Cell Carcinoma:

(show all 11)
# Title Authors Year
1
Primary Endometrial Squamous Cell Carcinoma in-situ with Extensive Icthyosis Uteri: A Rare Case Report. ( 28969146 )
2017
2
Primary Endometrial Squamous Cell Carcinoma In Situ: Report of a rare disease. ( 26629388 )
2015
3
Sister Mary Joseph's nodule associated with rare endometrial squamous cell carcinoma. ( 22562383 )
2012
4
Primary endometrial squamous cell carcinoma: a case report and review of relevant literature on korean women. ( 23110036 )
2012
5
Primary endometrial squamous cell carcinoma. ( 18236059 )
2008
6
Primary endometrial squamous cell carcinoma with extensive squamous metaplasia and dysplasia. ( 18603705 )
2008
7
Five-year survival of a patient with primary endometrial squamous cell carcinoma: a case report and review of the literature. ( 12214735 )
2002
8
Endometrial squamous cell carcinoma following whole pelvic radiation therapy: response to carboplatin. ( 7774850 )
1995
9
Primary endometrial squamous cell carcinoma with long-term survival. ( 7508224 )
1993
10
Endometrial squamous cell carcinoma. ( 1785281 )
1991
11
Endometrial squamous cell carcinoma: report of three cases and review of the literature. ( 2180795 )
1990

Variations for Endometrial Squamous Cell Carcinoma

Cosmic variations for Endometrial Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM5035 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.646G>A p.V216M 10:87957864-87957864 8
2 COSM5152 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.388C>T p.R130* 10:87933147-87933147 8
3 COSM5219 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.388C>G p.R130G 10:87933147-87933147 8
4 COSM5154 PTEN endometrium,NS,carcinoma,squamous cell carcinoma c.697C>T p.R233* 10:87957915-87957915 8
5 COSM5661 CTNNB1 endometrium,NS,carcinoma,squamous cell carcinoma c.94G>T p.D32Y 3:41224606-41224606 8

Expression for Endometrial Squamous Cell Carcinoma

Search GEO for disease gene expression data for Endometrial Squamous Cell Carcinoma.

Pathways for Endometrial Squamous Cell Carcinoma

Pathways related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 CCND1 CDK6 CDKN2A ESR1 HGF MET
2
Show member pathways
12.71 CCND1 CDK6 HGF MET
3
Show member pathways
12.6 CCND1 CDK6 HGF MET
4
Show member pathways
12.57 AR CCND1 CDK6 CDKN2A
5
Show member pathways
12.41 CCND1 CDK6 CDKN2A ESR1 HGF MET
6
Show member pathways
12.37 CCND1 CDK6 CDKN2A
7 12.3 CCND1 CDK6 CDKN2A
8
Show member pathways
12.27 CCND1 HGF MET
9 12.22 AR CCND1 CDK6 CDKN2A ESR1 HGF
10
Show member pathways
12.21 CCND1 CDK6 CDKN2A
11 12.18 CCND1 CDK6 CDKN2A MET
12
Show member pathways
12.14 CCND1 CDK6 CDKN2A
13 12.12 CCND1 CDK6 CDKN2A
14
Show member pathways
12.1 CCND1 CDK6 CDKN2A
15 12.04 CCND1 CDK6 CDKN2A
16 11.93 CCND1 ESR1 HGF MET
17 11.89 CCND1 CDK6 CDKN2A
18 11.84 AR CCND1 ESR1
19
Show member pathways
11.83 CCND1 CDK6 CDKN2A ESR1 HGF MET
20
Show member pathways
11.8 CCND1 CDK6 CDKN2A ESR1 PGR
21 11.68 CCND1 CDK6 CDKN2A
22
Show member pathways
11.56 AR ESR1 PGR
23 11.38 CCND1 CDKN2A
24 11.36 CCND1 CDK6
25 11.35 HGF MET
26 11.33 HGF MET
27
Show member pathways
11.32 AR ESR1
28 11.3 AR CCND1 CDK6
29
Show member pathways
11.27 HGF MET
30 11.24 HGF MET
31 11.2 CCND1 ESR1
32 11.15 HGF MET
33 11.12 CCND1 CDK6
34 11.11 CDK6 CDKN2A
35 11.07 HGF MET
36 10.91 CCND1 ESR1
37 10.73 HGF MET

GO Terms for Endometrial Squamous Cell Carcinoma

Cellular components related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.43 AR CCND1 CDK6 CDKN2A ESR1 PGR
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCND1 CDK6

Biological processes related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.71 AR ESR1 PGR
2 positive regulation of protein kinase B signaling GO:0051897 9.7 ESR1 HGF MET
3 phosphatidylinositol phosphorylation GO:0046854 9.65 ESR1 HGF MET
4 G1/S transition of mitotic cell cycle GO:0000082 9.63 CCND1 CDK6 CDKN2A
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.63 AR CDKN2A ESR1 HGF MET PGR
6 positive chemotaxis GO:0050918 9.58 HGF MET
7 liver development GO:0001889 9.58 CCND1 HGF MET
8 animal organ regeneration GO:0031100 9.57 CCND1 HGF
9 negative regulation of autophagy GO:0010507 9.56 HGF MET
10 intracellular receptor signaling pathway GO:0030522 9.55 AR ESR1
11 hepatocyte growth factor receptor signaling pathway GO:0048012 9.51 HGF MET
12 steroid hormone mediated signaling pathway GO:0043401 9.5 AR ESR1 PGR
13 Leydig cell differentiation GO:0033327 9.49 AR CCND1
14 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.43 CDK6 CDKN2A
15 negative regulation of hydrogen peroxide-mediated programmed cell death GO:1901299 9.37 HGF MET
16 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.26 AR PGR
17 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 AR CCND1 ESR1 PGR
18 mammary gland alveolus development GO:0060749 8.8 AR CCND1 ESR1

Molecular functions related to Endometrial Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.71 AR CCND1 ESR1 PGR
2 transcription factor binding GO:0008134 9.67 AR CCND1 CDKN2A ESR1
3 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.65 AR ESR1 PGR
4 lipid binding GO:0008289 9.63 AR ESR1 PGR
5 ATPase binding GO:0051117 9.5 AR ESR1 PGR
6 cyclin-dependent protein serine/threonine kinase activity GO:0004693 9.43 CCND1 CDK6
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.43 ESR1 HGF MET
8 steroid hormone receptor activity GO:0003707 9.33 AR ESR1 PGR
9 nuclear receptor activity GO:0004879 9.13 AR ESR1 PGR
10 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Endometrial Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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