Endometrial Stromal Nodule disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Endometrial Stromal Nodule

MalaCards integrated aliases for Endometrial Stromal Nodule:

Name: Endometrial Stromal Nodule ¹² ¹⁵ ¹⁷ ⁷⁴

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1373

NCIt ⁵¹ C4262

SNOMED-CT ⁶⁹ 70971005

EFO ¹⁷ EFO_1000241

UMLS ⁷⁴ C0334485

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Summaries for Endometrial Stromal Nodule

Disease Ontology : ¹² An uterine benign neoplasm that has material basis in cells reminiscent of proliferative phase endometrial stroma.

MalaCards based summary : Endometrial Stromal Nodule is related to endometrial stromal tumor and chromosome 17q11.2 deletion syndrome, 1.4-mb. An important gene associated with Endometrial Stromal Nodule is YWHAE (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon), and among its related pathways/superpathways are Signaling events mediated by HDAC Class II and Ovarian Infertility Genes. Affiliated tissues include ovary, smooth muscle and kidney.

Wikipedia : ⁷⁷ An endometrial stromal nodule is a noninfiltrative, circumscribed proliferation of endometrial stromal... more...

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Related Diseases for Endometrial Stromal Nodule

Diseases related to Endometrial Stromal Nodule via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)

#	Related Disease	Score	Top Affiliating Genes
1	endometrial stromal tumor	28.2	BCOR JAZF1 MEAF6 MME NDUFB11 NUTM2A
2	chromosome 17q11.2 deletion syndrome, 1.4-mb	10.5	JAZF1 SUZ12
3	kidney sarcoma	10.4	BCOR YWHAE
4	smooth muscle tumor	10.4	MME PGR
5	kidney clear cell sarcoma	10.4	BCOR YWHAE
6	benign breast phyllodes tumor	10.4	MME PGR
7	progesterone-receptor positive breast cancer	10.3	CYP19A1 PGR
8	cystic nephroma	10.3	MME PGR
9	cervical carcinosarcoma	10.3	MME PGR
10	benign metastasizing leiomyoma	10.3	CYP19A1 PGR
11	gender identity disorder	10.3	CYP19A1 PGR
12	perivascular epithelioid cell tumor	10.3	MME PGR
13	papillary hidradenoma	10.3	MME PGR
14	estrogen excess	10.3	CYP19A1 PGR
15	adenosarcoma	10.3	MME PGR
16	mammographic density	10.3	CYP19A1 PGR
17	spermatocele	10.3	MME PGR
18	breast benign neoplasm	10.3	MME PGR
19	endometriosis of ovary	10.3	CYP19A1 PGR
20	thoracic benign neoplasm	10.3	MME PGR
21	vagina sarcoma	10.3	CALD1 NDUFB11
22	vaginal endometrial stromal sarcoma	10.3	CALD1 NDUFB11
23	pancreatic mucinous cystadenoma	10.2	MME PGR
24	mixed endometrial stromal and smooth muscle tumor	10.2	CALD1 MME
25	breast myofibroblastoma	10.2	CALD1 MME
26	mixed cell type cancer	10.2	MME PGR
27	lung combined type small cell carcinoma	10.2	CALD1 MME
28	cervical adenoma malignum	10.2	CALD1 MME
29	vulvar benign neoplasm	10.2	CALD1 PGR
30	vulvar leiomyoma	10.2	CALD1 PGR
31	cervical mucinous adenocarcinoma	10.2	CALD1 MME
32	uterine anomalies	10.2	CYP19A1 NDUFB11 PGR
33	breast fibroadenoma	10.2	CYP19A1 MME PGR
34	adenomyosis	10.2	CYP19A1 MME PGR
35	peritoneal benign neoplasm	10.2	CALD1 PGR
36	prostatic hypertrophy	10.2	CYP19A1 PGR
37	diffuse peritoneal leiomyomatosis	10.2	CALD1 PGR
38	leiomyoma	10.2	CYP19A1 MME PGR
39	reproductive organ benign neoplasm	10.2	CYP19A1 PGR
40	small cell sarcoma	10.1	BCOR CALD1
41	sarcomatoid squamous cell skin carcinoma	10.1	CALD1 MME
42	sarcoma	10.1
43	juvenile nasopharyngeal angiofibroma	10.1	CYP19A1 PGR
44	nephrogenic adenofibroma	10.0	CALD1 MME
45	heart sarcoma	10.0	JAZF1 PHF1
46	ileum cancer	10.0	CALD1 MME
47	endometriosis	10.0
48	ovary serous adenocarcinoma	10.0
49	uterine sarcoma	9.9	CYP19A1 MME
50	myxoid leiomyosarcoma	9.9	BCOR MME PGR YWHAE ZC3H7B

Graphical network of the top 20 diseases related to Endometrial Stromal Nodule:

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Symptoms & Phenotypes for Endometrial Stromal Nodule

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Drugs & Therapeutics for Endometrial Stromal Nodule

Search Clinical Trials , NIH Clinical Center for Endometrial Stromal Nodule

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Genetic Tests for Endometrial Stromal Nodule

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Anatomical Context for Endometrial Stromal Nodule

MalaCards organs/tissues related to Endometrial Stromal Nodule:

⁴²

Ovary, Smooth Muscle, Kidney, Skeletal Muscle, Placenta, Skin, Heart

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Publications for Endometrial Stromal Nodule

Articles related to Endometrial Stromal Nodule:

(show all 16)

#	Title	Authors	Year
1	Analysis of diagnosis and treatment of complicated cervical severe adhesion atresia after removal of endometrial stromal nodule: A case report. ( 29310409 )	Zhang R...Bai W	2017
2	Magnetic resonance imaging of an endometrial stromal nodule. ( 26461974 )	Ozaki K...Gabata T	2016
3	Diffusion-Weighted MRI and FDG-PET in Diagnosis of Endometrial Stromal Nodule. ( 25694838 )	Maruyama S...Kim T	2015
4	Endometrial stromal nodule - a case report. ( 25725687 )	Saleh FM...Mirza TT	2015
5	Endometrial stromal nodule of the vaginal wall with a review of vulvovaginal endometrial stromal neoplasms. ( 26076086 )	S?nchez-Ferrer ML...Nogales FF	2015
6	Endometrial Stromal Nodule: A Rarity and a Pathological Challenge. ( 26221551 )	Borg CS...Majeed HG	2015
7	Synchronous occurrence of endometrial stromal nodule with papillary serous carcinoma of ovary: report of a case and brief review of literature. ( 25404842 )	Mitra S...Mukhopadhyay S	2014
8	Endometrial stromal nodule: report of a case. ( 21423543 )	Fdili Alaoui FZ...Amarti A	2011
9	Endometrial stromal nodule with smooth muscle differentiation. ( 18417866 )	Geetha V...Bhat SS	2008
10	Endometrial stromal nodule embedded into term placenta. ( 18092965 )	Karpf EF...Regauer S	2007
11	Meningioma-like endometrial stromal nodule with a stromal-derived foam cell component. ( 16918981 )	Mooney EE...Nogales FF	2006
12	Simultaneous occurrence of hepatic focal nodular hyperplasia and uterine endometrial stromal nodule in a patient having treated breast infiltrating ductal carcinoma. ( 12780434 )	Chen CA...Chen M	2003
13	Hormonal treatment of an endometrial stromal nodule followed by local excision. ( 10912400 )	Schilder JM...Sutton GP	1999
14	Endometrial stromal nodule with retiform sex-cord-like differentiation. ( 9689655 )	Z?mecn?k M...Michal M	1998
15	Ultrastructure of an endometrial stromal nodule with skeletal muscle. ( 8266600 )	Lloreta J...Prat J	1993
16	Endometrial stromal nodule with smooth and skeletal muscle components simulating stromal sarcoma. ( 1399235 )	Lloreta J...Prat J	1992

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Genes for Endometrial Stromal Nodule

Genes related to Endometrial Stromal Nodule (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	17.24	DISEASES inferred ¹⁵
2	JAZF1	JAZF Zinc Finger 1	Protein Coding	16.44	DISEASES inferred ¹⁵
3	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	16.23	DISEASES inferred ¹⁵
4	NDUFB11	NADH:Ubiquinone Oxidoreductase Subunit B11	Protein Coding	15.93	DISEASES inferred ¹⁵
5	BCOR	BCL6 Corepressor	Protein Coding	15.74	DISEASES inferred ¹⁵
6	MME	Membrane Metalloendopeptidase	Protein Coding	14.94	DISEASES inferred ¹⁵
7	PGR	Progesterone Receptor	Protein Coding	13.64	DISEASES inferred ¹⁵
8	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	13.54	DISEASES inferred ¹⁵
9	NUTM2A	NUT Family Member 2A	Protein Coding	6.9	DISEASES inferred ¹⁵
10	EZHIP	EZH Inhibitory Protein	Protein Coding	6.9	DISEASES inferred ¹⁵
11	MBTD1	Mbt Domain Containing 1	Protein Coding	6.56	DISEASES inferred ¹⁵
12	MEAF6	MYST/Esa1 Associated Factor 6	Protein Coding	6.27	DISEASES inferred ¹⁵
13	ZC3H7B	Zinc Finger CCCH-Type Containing 7B	Protein Coding	6.26	DISEASES inferred ¹⁵
14	IFITM1	Interferon Induced Transmembrane Protein 1	Protein Coding	5.17	DISEASES inferred ¹⁵
15	NR4A3	Nuclear Receptor Subfamily 4 Group A Member 3	Protein Coding	5.02	DISEASES inferred ¹⁵
16	PHF1	PHD Finger Protein 1	Protein Coding	4.87	DISEASES inferred ¹⁵
17	CALD1	Caldesmon 1	Protein Coding	4.31	DISEASES inferred ¹⁵

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Variations for Endometrial Stromal Nodule

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Expression for Endometrial Stromal Nodule

Search GEO for disease gene expression data for Endometrial Stromal Nodule.

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Pathways for Endometrial Stromal Nodule

Pathways related to Endometrial Stromal Nodule according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signaling events mediated by HDAC Class II ¹	10.49	BCOR YWHAE
2	Ovarian Infertility Genes ¹	10.13	CYP19A1 PGR

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GO Terms for Endometrial Stromal Nodule

Cellular components related to Endometrial Stromal Nodule according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ESC/E(Z) complex	GO:0035098	8.62	PHF1 SUZ12

Biological processes related to Endometrial Stromal Nodule according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin organization	GO:0006325	9.02	BCOR MBTD1 MEAF6 PHF1 SUZ12
2	mammary gland development	GO:0030879	8.96	CYP19A1 PGR

Molecular functions related to Endometrial Stromal Nodule according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	metal ion binding	GO:0046872	9.61	CYP19A1 JAZF1 MBTD1 MME NR4A3 PGR
2	methylated histone binding	GO:0035064	8.8	MBTD1 PHF1 SUZ12

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