MCID: END043
MIFTS: 34

Endometrial Stromal Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Stromal Tumor

MalaCards integrated aliases for Endometrial Stromal Tumor:

Name: Endometrial Stromal Tumor 12 15 17
Endometrial Stromal Neoplasm 12
Endometrial Stromal Tumors 44

Classifications:



External Ids:

Disease Ontology 12 DOID:5166
MeSH 44 D036821
SNOMED-CT 67 68738004
UMLS 70 C0334695

Summaries for Endometrial Stromal Tumor

MalaCards based summary : Endometrial Stromal Tumor, also known as endometrial stromal neoplasm, is related to vaginal endometrial stromal tumor and endometrial stromal nodule. An important gene associated with Endometrial Stromal Tumor is U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1), and among its related pathways/superpathways are Gene Expression and Translational Control. The drugs Exemestane and Anastrozole have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and kidney, and related phenotypes are Increased homologous recombination repair frequency and Increased SMN2 exon 7 inclusion

Related Diseases for Endometrial Stromal Tumor

Diseases related to Endometrial Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 vaginal endometrial stromal tumor 32.8 MME CALD1
2 endometrial stromal nodule 31.5 ZC3H7B ZC3H7A YWHAE SUZ12 PHF1 NUTM2A
3 intravenous leiomyomatosis 30.8 MME CALD1
4 endometrial stromal sarcoma 30.7 ZC3H7B ZC3H7A YWHAE U2AF1 SUZ12 SRSF1
5 mixed endometrial stromal and smooth muscle tumor 30.6 MME CALD1
6 mesenchymal cell neoplasm 30.5 ZC3H7B MME CALD1
7 cellular leiomyoma 30.4 SUZ12 MME JAZF1 CALD1
8 myxoid leiomyosarcoma 30.2 ZC3H7B YWHAE MEAF6 MBTD1 EZHIP CALD1
9 uterine corpus endometrial stromal sarcoma 11.2
10 cervix endometrial stromal tumor 11.2
11 fallopian tube leiomyoma 10.4 MME CALD1
12 urethra leiomyoma 10.4 MME CALD1
13 fallopian tube benign neoplasm 10.4 MME CALD1
14 atrophy of testis 10.4 MEAF6 H2AC18
15 breast myofibroblastoma 10.4 MME CALD1
16 subareolar duct papillomatosis 10.4 MME CALD1
17 posterior fossa ependymoma 10.4 SUZ12 EZHIP
18 lung combined type small cell carcinoma 10.4 MME CALD1
19 cervical mucinous adenocarcinoma 10.4 MME CALD1
20 nipple benign neoplasm 10.4 MME CALD1
21 cellular congenital mesoblastic nephroma 10.4 YWHAE NUTM2B
22 heart sarcoma 10.4 ZC3H7B MEAF6 JAZF1
23 adenosarcoma 10.4 PHF1 MME JAZF1
24 cervical polyp 10.4 MME CALD1
25 sarcomatoid squamous cell skin carcinoma 10.4 MME CALD1
26 kidney cortex disease 10.4 U2AF1 NUTM2B MME
27 kidney clear cell sarcoma 10.4 ZC3H7B YWHAE NUTM2B
28 uterus perivascular epithelioid cell tumor 10.4 MME CALD1
29 kidney rhabdoid cancer 10.4 YWHAE NUTM2B
30 mixed cell type cancer 10.4 MME H2AC18 CALD1
31 vulvar leiomyoma 10.4 MME CALD1
32 splenic disease 10.4 U2AF1 MT-CYB H2AC18
33 atypical polypoid adenomyoma 10.4 MME CALD1
34 connective tissue benign neoplasm 10.4 MME H2AC18 CALD1
35 kidney sarcoma 10.4 YWHAE NUTM2B
36 adenomyoma 10.4 MME CALD1
37 mature b-cell neoplasm 10.4 U2AF1 MME H2AC18
38 ovarian sex-cord stromal tumor 10.3 ZC3H7B SUZ12 MME JAZF1
39 urethral benign neoplasm 10.3 MME CALD1
40 uterine benign neoplasm 10.3 MME JAZF1 H2AC18 CALD1
41 cervical adenoma malignum 10.3 MME CALD1
42 reproductive organ benign neoplasm 10.3 MME JAZF1 H2AC18 CALD1
43 atrial septal defect 2 10.3 U2AF1 HNRNPDL HNRNPC
44 cervical adenosarcoma 10.3 SUZ12 MME JAZF1 CALD1
45 inclusion body myopathy with paget disease of bone and frontotemporal dementia 10.3 MT-CYB HNRNPA1 H2AC18
46 vaginal cancer 10.3 MME CALD1
47 leukocyte disease 10.3 U2AF1 MME H2AC18
48 mucocutaneous leishmaniasis 10.3 MT-CYB H2AC18
49 ossifying fibromyxoid tumor 10.3 ZC3H7B PHF1 MEAF6 MBTD1
50 multisystem proteinopathy 10.3 HNRNPDL HNRNPC HNRNPA1

Graphical network of the top 20 diseases related to Endometrial Stromal Tumor:



Diseases related to Endometrial Stromal Tumor

Symptoms & Phenotypes for Endometrial Stromal Tumor

GenomeRNAi Phenotypes related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased homologous recombination repair frequency GR00151-A-1 8.96 SUZ12 YWHAE
2 Increased SMN2 exon 7 inclusion GR00254-A 8.62 HNRNPA1 U2AF1

Drugs & Therapeutics for Endometrial Stromal Tumor

Drugs for Endometrial Stromal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
2
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
3
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
4
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
5 Estrogen Antagonists Phase 2
6 Hormones Phase 2
7 Estrogen Receptor Antagonists Phase 2
8 Hormone Antagonists Phase 2
9 Aromatase Inhibitors Phase 2
10 Estrogens Phase 2
11 Histone Deacetylase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Comparative Prospective Multicentre Phase II Trial Evaluating Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic LGESS Recruiting NCT03624244 Phase 2 Aromatase Inhibitors
2 A Pilot Study of Peroral Vorinostat (SAHA) in Patients With Refractory Histone Deacetylase-positive Uterine Sarcoma Terminated NCT03509207 Phase 2 Vorinostat Oral Capsule
3 Endometrial Stromal Tumors: an Observational Study Recruiting NCT02829437

Search NIH Clinical Center for Endometrial Stromal Tumor

Cochrane evidence based reviews: endometrial stromal tumors

Genetic Tests for Endometrial Stromal Tumor

Anatomical Context for Endometrial Stromal Tumor

MalaCards organs/tissues related to Endometrial Stromal Tumor:

40
Smooth Muscle, Uterus, Kidney, Ovary, Bone, Heart, Placenta

Publications for Endometrial Stromal Tumor

Articles related to Endometrial Stromal Tumor:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Uterine tumor resembling ovarian sex-cord tumor: Conservative surgery with successful delivery and case series. 61
33264692 2021
2
Uterine Tumor Resembling Sex-Cord Tumor: A Case Report. 61
33324531 2020
3
Inflammatory Myofibroblastic Tumor of the Uterus: An Immunohistochemical Study of 23 Cases. 61
32568825 2020
4
[New insight and research advances of endometrial stromal tumors]. 61
32992432 2020
5
Detection of MEAF6-PHF1 translocation in an endometrial stromal nodule. 61
32820570 2020
6
Uterine Endometrial Stromal Tumors With Limited Infiltration: First Report of a Case Series Indicating Potential for Malignant Behavior. 61
30807369 2020
7
A High-Grade Undifferentiated Endometrial Stromal Sarcoma Presenting as Inversion of the Uterus: A Rare Case. 61
32684727 2020
8
Uterine lesions with sex cord-like architectures: a systematic review. 61
31739799 2019
9
Clinicopathologic Characterization of GREB1-rearranged Uterine Sarcomas With Variable Sex-Cord Differentiation. 61
31094921 2019
10
PGR Gene Fusions Identify a Molecular Subset of Uterine Epithelioid Leiomyosarcoma With Rhabdoid Features. 61
30829727 2019
11
Uterine Mesenchymal Tumors: Update on Classification, Staging, and Molecular Features. 61
31097109 2019
12
Inflammatory Myofibroblastic Tumor in Female Genital Tract. 61
29965784 2019
13
Myxoid endometrial stromal sarcoma: report of two cases with emphasis on its diagnostic problems. 61
31933960 2019
14
Recent advances in the histological and molecular classification of endometrial stromal neoplasms. 61
30324234 2018
15
Can the classification of low-grade endometrial stromal tumors still be improved? 61
30367239 2018
16
Pitfalls of Frozen Section in Gynecological Pathology: A Case of Endometrial Tumor With Sex Cord-Like Elements. 61
29488417 2018
17
Angioleiomyoma of Uterus: A Clinicopathologic Study of 6 Cases. 61
28905674 2018
18
Endometrial stromal tumor with sex-cord-like elements. 61
30084482 2018
19
Endometrial stromal sarcoma in a 27-year-old woman. Case report and literature review. 61
30534836 2018
20
Low-Grade Endometrial Stromal Sarcoma - a Review. 61
30317238 2018
21
Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas. 61
28570276 2017
22
Uterine Sarcomas: The Latest Approaches for These Rare but Potentially Deadly Tumors. 61
28299760 2017
23
Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis. 61
28125717 2017
24
Cytogenetic and molecular profile of endometrial stromal sarcoma. 61
27219024 2016
25
Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review. 61
27590366 2016
26
Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. 61
27154512 2016
27
Extensive Overgrowth of Sex Cord-Like Differentiation in Uterine Mullerian Adenosarcoma: A Rare and Challenging Entity. 61
26840033 2016
28
Uterine tumors resembling ovarian sex cord tumors: A case report and literature review. 61
26893767 2016
29
Conservative Resectoscopic Surgery, Successful Delivery, and 60 Months of Follow-Up in a Patient with Endometrial Stromal Tumor with Sex-Cord-Like Differentiation. 61
27213063 2016
30
Practical issues in uterine pathology from banal to bewildering: the remarkable spectrum of smooth muscle neoplasia. 61
26715170 2016
31
Practical issues related to uterine pathology: endometrial stromal tumors. 61
26715176 2016
32
Analysis of MDM2 Amplification in 43 Endometrial Stromal Tumors: A Potential Diagnostic Pitfall. 61
26444253 2015
33
High grade endometrial stromal sarcoma on thinprep. 61
26174064 2015
34
JAZF1 promotes proliferation of C2C12 cells, but retards their myogenic differentiation through transcriptional repression of MEF2C and MRF4-Implications for the role of Jazf1 variants in oncogenesis and type 2 diabetes. 61
26101156 2015
35
"Pseudomyxoma Endometrii": Endometrial Deposition of Acellular Mucin from a Low-Grade Appendiceal Mucinous Neoplasm as a Rare Mimic of Myxoid Uterine Tumors. 61
25851710 2015
36
Genomic characterization of endometrial stromal sarcomas with array comparative genomic hybridization. 61
25758203 2015
37
Corrigendum. 61
25614465 2015
38
Clinical experience of uterine tumors resembling ovarian sex cord tumors: a clinicopathological analysis of 6 cases. 61
26097607 2015
39
Endometrial Stromal Nodule: A Rarity and a Pathological Challenge. 61
26221551 2015
40
Cellular leiomyoma versus endometrial stromal tumor: A pathologists' dilemma. 61
25861206 2015
41
Clinical characteristics, pathological reevaluation, surgical management and adjuvant therapy of patients with endometrial stromal tumors. 61
24981048 2014
42
Endometrial stromal tumors: the new WHO classification. 61
25299308 2014
43
Clinical characteristics and outcomes of uterine tumors resembling ovarian sex-cord tumors (UTROSCT): a systematic review of literature. 61
25150955 2014
44
Malignant potential of endometrial stromal tumor with limited infiltration: a case report. 61
24155223 2014
45
Transgelin, a Novel Marker of Smooth Muscle Differentiation, Effectively Distinguishes Endometrial Stromal Tumors from Uterine Smooth Muscle Tumors. 61
26023684 2014
46
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations. 61
24901397 2014
47
Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry. 61
24309325 2014
48
Diagnostic use of immunohistochemistry in uterine mesenchymal tumors. 61
24863031 2014
49
Colonic low-grade endometrial stromal sarcoma and orthotopic endometrial stromal tumor with limited infiltration sharing the JAZF1-SUZ12 gene fusion. 61
24750188 2014
50
A uterine tumor resembling ovarian sex cord tumor associated with tamoxifen treatment: a case report and literature review. 61
24487470 2014

Variations for Endometrial Stromal Tumor

Expression for Endometrial Stromal Tumor

Search GEO for disease gene expression data for Endometrial Stromal Tumor.

Pathways for Endometrial Stromal Tumor

Pathways related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 YWHAE U2AF1 SUZ12 SRSF1 PHF1 MEAF6
2 11.21 U2AF1 SRSF1 HNRNPC HNRNPA1

GO Terms for Endometrial Stromal Tumor

Cellular components related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.03 ZC3H7B ZC3H7A YWHAE U2AF1 SUZ12 SRSF1
2 ESC/E(Z) complex GO:0035098 9.26 SUZ12 PHF1
3 catalytic step 2 spliceosome GO:0071013 9.26 U2AF1 SRSF1 HNRNPC HNRNPA1
4 spliceosomal complex GO:0005681 9.02 U2AF1 SRSF1 HNRNPDL HNRNPC HNRNPA1

Biological processes related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.67 SUZ12 PHF1 MEAF6 MBTD1
2 RNA splicing GO:0008380 9.62 U2AF1 SRSF1 HNRNPC HNRNPA1
3 mRNA splicing, via spliceosome GO:0000398 9.46 U2AF1 SRSF1 HNRNPC HNRNPA1
4 negative regulation of telomere maintenance via telomerase GO:0032211 9.4 HNRNPC HNRNPA1
5 production of miRNAs involved in gene silencing by miRNA GO:0035196 9.26 ZC3H7B ZC3H7A
6 RNA export from nucleus GO:0006405 9.13 U2AF1 SRSF1 HNRNPA1
7 negative regulation of histone H3-K27 methylation GO:0061086 8.62 PHF1 EZHIP

Molecular functions related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.56 ZC3H7B ZC3H7A YWHAE U2AF1 SRSF1 HNRNPDL
2 methylated histone binding GO:0035064 9.33 SUZ12 PHF1 MBTD1
3 RNA polymerase II transcription corepressor binding GO:0001226 9.26 SUZ12 PHF1
4 miRNA binding GO:0035198 8.8 ZC3H7B ZC3H7A HNRNPA1

Sources for Endometrial Stromal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....