MCID: END043
MIFTS: 32

Endometrial Stromal Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Stromal Tumor

MalaCards integrated aliases for Endometrial Stromal Tumor:

Name: Endometrial Stromal Tumor 12 15
Endometrial Stromal Tumors 13 44
Endometrial Stromal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5166
MeSH 44 D036821
SNOMED-CT 68 68738004
UMLS 73 C0334695

Summaries for Endometrial Stromal Tumor

MalaCards based summary : Endometrial Stromal Tumor, also known as endometrial stromal tumors, is related to endometrial stromal sarcoma and endometrial stromal nodule. An important gene associated with Endometrial Stromal Tumor is NDUFB11 (NADH:Ubiquinone Oxidoreductase Subunit B11), and among its related pathways/superpathways is Signaling events mediated by HDAC Class II. The drugs Mifepristone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and colon.

Related Diseases for Endometrial Stromal Tumor

Graphical network of the top 20 diseases related to Endometrial Stromal Tumor:



Diseases related to Endometrial Stromal Tumor

Symptoms & Phenotypes for Endometrial Stromal Tumor

Drugs & Therapeutics for Endometrial Stromal Tumor

Drugs for Endometrial Stromal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mifepristone Approved, Investigational Phase 2 84371-65-3 55245
2
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
6
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
7
Nivolumab Approved Phase 2 946414-94-4
8
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
9
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
10
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
11
Trebananib Investigational Phase 2 894356-79-7
12
Saracatinib Investigational Phase 2 379231-04-6
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
14 Contraceptives, Oral Phase 2
15 Contraceptive Agents Phase 2
16 Contraceptives, Postcoital Phase 2
17 Luteolytic Agents Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Antineoplastic Agents, Hormonal Phase 2
21 Cortisol succinate Phase 2
22
protease inhibitors Phase 2
23 BB 1101 Phase 2
24 glucocorticoids Phase 2
25 Autonomic Agents Phase 2
26 Antiemetics Phase 2
27 Anti-Inflammatory Agents Phase 2
28 Hydrocortisone 17-butyrate 21-propionate Phase 2
29 Peripheral Nervous System Agents Phase 2
30 Gastrointestinal Agents Phase 2
31 HIV Protease Inhibitors Phase 2
32 Angiogenesis Modulating Agents Phase 2
33 Angiogenesis Inhibitors Phase 2
34 Histone Deacetylase Inhibitors Phase 2
35 Antibodies, Monoclonal Phase 2
36 Immunoglobulins Phase 2
37 Immunologic Factors Phase 2
38 Antibodies Phase 2
39 Aromatase Inhibitors Phase 2
40 Estrogens Phase 2
41 Steroid Synthesis Inhibitors Phase 2
42 Estrogen Receptor Antagonists Phase 2
43 Estrogen Antagonists Phase 2
44
Formaldehyde Approved, Vet_approved 50-00-0 712

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mifepristone for Patients With Endometrial Cancer and LGESS Completed NCT00505739 Phase 2 Mifepristone
2 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
3 Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed NCT01210222 Phase 2
4 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
5 Vorinostat (SAHA) in Uterine Sarcoma Recruiting NCT03509207 Phase 2 Vorinostat Oral Capsule
6 A Study of Nivolumab in Selected Uterine Cancer Patients Recruiting NCT03241745 Phase 2 Nivolumab
7 Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS) Not yet recruiting NCT03624244 Phase 2 Aromatase Inhibitors
8 A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma Not yet recruiting NCT02982486 Phase 2 Ipilimumab;Nivolumab
9 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
10 Observational Study on Endometrial Stromal Tumors Recruiting NCT02829437

Search NIH Clinical Center for Endometrial Stromal Tumor

Cochrane evidence based reviews: endometrial stromal tumors

Genetic Tests for Endometrial Stromal Tumor

Anatomical Context for Endometrial Stromal Tumor

MalaCards organs/tissues related to Endometrial Stromal Tumor:

41
Smooth Muscle, Uterus, Colon, Kidney, Heart, Breast, Cervix

Publications for Endometrial Stromal Tumor

Articles related to Endometrial Stromal Tumor:

(show all 40)
# Title Authors Year
1
Endometrial stromal tumor with sex-cord-like elements. ( 30084482 )
2018
2
Can the classification of low-grade endometrial stromal tumors still be improved? ( 30367239 )
2018
3
Conservative Resectoscopic Surgery, Successful Delivery, and 60 Months of Follow-Up in a Patient with Endometrial Stromal Tumor with Sex-Cord-Like Differentiation. ( 27213063 )
2016
4
Practical issues related to uterine pathology: endometrial stromal tumors. ( 26715176 )
2016
5
Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. ( 27154512 )
2016
6
Cellular leiomyoma versus endometrial stromal tumor: A pathologists' dilemma. ( 25861206 )
2015
7
Analysis of MDM2 Amplification in 43 Endometrial Stromal Tumors: A Potential Diagnostic Pitfall. ( 26444253 )
2015
8
Colonic low-grade endometrial stromal sarcoma and orthotopic endometrial stromal tumor with limited infiltration sharing the JAZF1-SUZ12 gene fusion. ( 24750188 )
2014
9
Diagnosis of endometrial stromal tumors: a clinicopathologic study of 25 biopsy specimens with identification of problematic areas. ( 24343747 )
2014
10
Clinical characteristics, pathological reevaluation, surgical management and adjuvant therapy of patients with endometrial stromal tumors. ( 24981048 )
2014
11
Endometrial stromal tumors: the new WHO classification. ( 25299308 )
2014
12
Transgelin, a Novel Marker of Smooth Muscle Differentiation, Effectively Distinguishes Endometrial Stromal Tumors from Uterine Smooth Muscle Tumors. ( 26023684 )
2014
13
Malignant Potential of an Endometrial Stromal Tumor With Limited Infiltration: A Case Report. ( 24155223 )
2013
14
Endometrial stromal tumors: immunohistochemical and molecular analysis of potential targets of tyrosine kinase inhibitors. ( 23497641 )
2013
15
A well circumscribed uterine endometrial stromal tumor with smooth muscle differentiation recurred as a low grade endometrial stromal sarcoma: is tumor margin enough for the diagnosis? ( 22524669 )
2012
16
Outcome and prognostic factors in endometrial stromal tumors: a Rare Cancer Network study. ( 22300565 )
2012
17
Tumor dissemination after laparoscopic surgery for an unsuspected endometrial stromal tumor. ( 21797138 )
2011
18
Cytogenetic and molecular aberrations in endometrial stromal tumors. ( 21420714 )
2011
19
Frequency of known gene rearrangements in endometrial stromal tumors. ( 21836477 )
2011
20
Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas. ( 19898427 )
2010
21
Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors. ( 19542872 )
2009
22
Diagnostic use of nuclear beta-catenin expression for the assessment of endometrial stromal tumors. ( 18376386 )
2008
23
High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. ( 17667554 )
2007
24
Meningothelial-like nodules: additional pattern of myoid differentiation in endometrial stromal tumors. ( 17685938 )
2007
25
An endometrial stromal tumor with osteoclast-like giant cells. ( 15944960 )
2005
26
Endometrial stromal tumor with limited infiltration and probable extrauterine metastasis: report of a case. ( 15692954 )
2005
27
Unusual morphologic features of endometrial stromal tumors: a report of 2 cases. ( 16160484 )
2005
28
Recurrent endometrial stromal tumors with smooth-muscle differentiation and a protracted clinical course. ( 16270099 )
2005
29
Endometrial stromal nodules and endometrial stromal tumors with limited infiltration: a clinicopathologic study of 50 cases. ( 11979087 )
2002
30
h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. ( 11257619 )
2001
31
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. ( 11371647 )
2001
32
Endometrial stromal tumors: an update on a group of tumors with a protean phenotype. ( 10976906 )
2000
33
Myxoid and fibrous endometrial stromal tumors of the uterus: a report of 10 cases. ( 10542938 )
1999
34
Role of electron microscopy in metastatic endometrial stromal tumors. ( 8266599 )
1993
35
Histologic and immunohistochemical analysis of nine endometrial stromal tumors: an unexpected high frequency of keratin protein positivity. ( 1709624 )
1991
36
Treatment of endometrial stromal tumors. ( 2295453 )
1990
37
Uterine tumor resembling an ovarian sex-cord tumor: report of a case of an endometrial stromal tumor with foam cells and ultrastructural evidence of epithelial differentiation. ( 4086162 )
1985
38
Endometrial stromal tumors, their varied radiographic patterns. ( 7233641 )
1980
39
Endometrial stromal tumor in a chimpanzee. ( 1166571 )
1975
40
Mesenchymal tumors of the uterus. I. A clinical and pathological study of 53 endometrial stromal tumors. ( 5939046 )
1966

Variations for Endometrial Stromal Tumor

Expression for Endometrial Stromal Tumor

Search GEO for disease gene expression data for Endometrial Stromal Tumor.

Pathways for Endometrial Stromal Tumor

Pathways related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.15 BCOR YWHAE

GO Terms for Endometrial Stromal Tumor

Cellular components related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 BCOR JAZF1 MEAF6 PARVA PGR PHF1
2 ESC/E(Z) complex GO:0035098 8.62 PHF1 SUZ12

Biological processes related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.02 BCOR MEAF6 PHF1 SMARCA1 SUZ12
2 negative regulation of gene expression, epigenetic GO:0045814 8.96 PHF1 SUZ12

Molecular functions related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosome binding GO:0031491 8.62 PHF1 SMARCA1

Sources for Endometrial Stromal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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