MCID: END043
MIFTS: 35

Endometrial Stromal Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrial Stromal Tumor

MalaCards integrated aliases for Endometrial Stromal Tumor:

Name: Endometrial Stromal Tumor 12 15 17
Endometrial Stromal Tumors 13 45
Endometrial Stromal Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5166
MeSH 45 D036821
SNOMED-CT 69 68738004
UMLS 74 C0334695

Summaries for Endometrial Stromal Tumor

MalaCards based summary : Endometrial Stromal Tumor, also known as endometrial stromal tumors, is related to leiomyoma and endometrial stromal sarcoma. An important gene associated with Endometrial Stromal Tumor is NDUFB11 (NADH:Ubiquinone Oxidoreductase Subunit B11), and among its related pathways/superpathways is Signaling events mediated by HDAC Class II. The drugs Mifepristone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, kidney and cervix.

Related Diseases for Endometrial Stromal Tumor

Diseases related to Endometrial Stromal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.0 ESR1 MME PGR
2 endometrial stromal sarcoma 29.7 BCOR ESR1 JAZF1 MEAF6 MME NDUFB11
3 endometrial stromal nodule 29.2 BCOR JAZF1 MEAF6 MME NDUFB11 NUTM2A
4 cervix endometrial stromal tumor 12.3
5 vaginal endometrial stromal tumor 12.3
6 uterine corpus endometrial stromal sarcoma 11.3
7 chromosome 17q11.2 deletion syndrome, 1.4-mb 10.4 JAZF1 SUZ12
8 kidney sarcoma 10.4 BCOR YWHAE
9 kidney clear cell sarcoma 10.3 BCOR YWHAE
10 benign breast phyllodes tumor 10.3 MME PGR
11 breast myofibroblastoma 10.3 ESR1 MME
12 intravenous leiomyomatosis 10.3 ESR1 MME
13 cystic nephroma 10.3 MME PGR
14 perivascular epithelioid cell tumor 10.3 MME PGR
15 vestibular gland benign neoplasm 10.3 ESR1 PGR
16 bartholin's gland adenoma 10.3 ESR1 PGR
17 vulvar syringoma 10.3 ESR1 PGR
18 lung leiomyoma 10.3 ESR1 PGR
19 glassy cell carcinoma of the cervix 10.3 ESR1 PGR
20 papillary hidradenoma 10.3 MME PGR
21 vulvar benign neoplasm 10.3 ESR1 PGR
22 trigonitis 10.3 ESR1 PGR
23 vulvar leiomyoma 10.3 ESR1 PGR
24 predominantly cortical thymoma 10.3 ESR1 PGR
25 breast medullary carcinoma 10.3 ESR1 PGR
26 breast scirrhous carcinoma 10.3 ESR1 PGR
27 bartholin's gland benign neoplasm 10.3 ESR1 PGR
28 oncocytic breast carcinoma 10.3 ESR1 PGR
29 progesterone-receptor positive breast cancer 10.3 ESR1 PGR
30 progesterone resistance 10.3 ESR1 PGR
31 endometrial squamous cell carcinoma 10.2 ESR1 PGR
32 cribriform carcinoma 10.2 ESR1 PGR
33 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
34 adenoid basal cell carcinoma 10.2 ESR1 PGR
35 apocrine adenocarcinoma 10.2 ESR1 PGR
36 spermatocele 10.2 MME PGR
37 peritoneal benign neoplasm 10.2 ESR1 PGR
38 gender identity disorder 10.2 ESR1 PGR
39 deep angioma 10.2 ESR1 PGR
40 diffuse peritoneal leiomyomatosis 10.2 ESR1 PGR
41 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
42 breast adenoid cystic carcinoma 10.2 ESR1 PGR
43 female reproductive endometrioid cancer 10.2 ESR1 PGR
44 estrogen excess 10.2 ESR1 PGR
45 intramuscular hemangioma 10.2 ESR1 PGR
46 pancreatic mucinous cystadenoma 10.2 MME PGR
47 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
48 mammographic density 10.2 ESR1 PGR
49 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
50 retinitis pigmentosa 47 10.2 ESR1 PGR

Graphical network of the top 20 diseases related to Endometrial Stromal Tumor:



Diseases related to Endometrial Stromal Tumor

Symptoms & Phenotypes for Endometrial Stromal Tumor

Drugs & Therapeutics for Endometrial Stromal Tumor

Drugs for Endometrial Stromal Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mifepristone Approved, Investigational Phase 2 84371-65-3 55245
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
4
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
5
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
6
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
7
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
8
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
9
Fulvestrant Approved, Investigational Phase 2 129453-61-8 17756771 104741
10
nivolumab Approved Phase 2 946414-94-4
11
Ipilimumab Approved Phase 2 477202-00-9
12
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
13
Trebananib Investigational Phase 2 894356-79-7
14
Saracatinib Investigational Phase 2 379231-04-6
15 Hormone Antagonists Phase 2
16 Contraceptives, Oral Phase 2
17 Contraceptives, Postcoital Phase 2
18 Luteolytic Agents Phase 2
19 Contraceptive Agents Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Hormones Phase 2
22 Hydrocortisone 17-butyrate 21-propionate Phase 2
23 Antineoplastic Agents, Hormonal Phase 2
24 Antiemetics Phase 2
25 Gastrointestinal Agents Phase 2
26 glucocorticoids Phase 2
27 HIV Protease Inhibitors Phase 2
28 BB 1101 Phase 2
29 Hydrocortisone hemisuccinate Phase 2
30 Anti-Inflammatory Agents Phase 2
31
protease inhibitors Phase 2
32 Peripheral Nervous System Agents Phase 2
33 Autonomic Agents Phase 2
34 Angiogenesis Modulating Agents Phase 2
35 Angiogenesis Inhibitors Phase 2
36 Steroid Synthesis Inhibitors Phase 2
37 Estrogen Receptor Antagonists Phase 2
38 Estrogen Antagonists Phase 2
39 Aromatase Inhibitors Phase 2
40 Estrogens Phase 2
41 Antineoplastic Agents, Immunological Phase 2
42 Histone Deacetylase Inhibitors Phase 2
43
Formaldehyde Approved, Vet_approved 50-00-0 712

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Mifepristone for Patients With Endometrial Cancer and LGESS Completed NCT00505739 Phase 2 Mifepristone
2 Medical Safety Follow-up Study for Patients Who Received More Than 28 Days of Total Exposure to BGG492 Completed NCT02150213 Phase 2 BGG492
3 Trebananib in Treating Patients With Persistent or Recurrent Endometrial Cancer Completed NCT01210222 Phase 2
4 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
5 Evaluation of Clinical Impact of Interruption VS Maintenance of AI in Patients With Locally Advanced/ Metastatic Low Grade Endometrial Stromal Sarcoma (LGESS) Recruiting NCT03624244 Phase 2 Aromatase Inhibitors
6 FUlvestrant in Gynecological Cancers That Are Potentially Hormone Sensitive: the FUCHSia Study Recruiting NCT03926936 Phase 2 Fulvestrant
7 A Study of Nivolumab in Selected Uterine Cancer Patients Recruiting NCT03241745 Phase 2 Nivolumab
8 A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial Carcinoma Not yet recruiting NCT02982486 Phase 2 Ipilimumab;Nivolumab
9 Vorinostat (SAHA) in Uterine Sarcoma Terminated NCT03509207 Phase 2 Vorinostat Oral Capsule
10 Collecting Tumor Samples From Patients With Gynecological Tumors Completed NCT00897442
11 Observational Study on Endometrial Stromal Tumors Recruiting NCT02829437

Search NIH Clinical Center for Endometrial Stromal Tumor

Cochrane evidence based reviews: endometrial stromal tumors

Genetic Tests for Endometrial Stromal Tumor

Anatomical Context for Endometrial Stromal Tumor

MalaCards organs/tissues related to Endometrial Stromal Tumor:

42
Smooth Muscle, Kidney, Cervix, Uterus, Colon, Heart, Ovary

Publications for Endometrial Stromal Tumor

Articles related to Endometrial Stromal Tumor:

(show all 41)
# Title Authors Year
1
Uterine Endometrial Stromal Tumors With Limited Infiltration: First Report of a Case Series Indicating Potential for Malignant Behavior. ( 30807369 )
2019
2
Endometrial stromal tumor with sex-cord-like elements. ( 30084482 )
2018
3
Can the classification of low-grade endometrial stromal tumors still be improved? ( 30367239 )
2018
4
Conservative Resectoscopic Surgery, Successful Delivery, and 60 Months of Follow-Up in a Patient with Endometrial Stromal Tumor with Sex-Cord-Like Differentiation. ( 27213063 )
2016
5
Practical issues related to uterine pathology: endometrial stromal tumors. ( 26715176 )
2016
6
Molecular Cytogenetic Analysis of JAZF1, PHF1, and YWHAE in Endometrial Stromal Tumors: Discovery of Genetic Complexity by Fluorescence in Situ Hybridization. ( 27154512 )
2016
7
Cellular leiomyoma versus endometrial stromal tumor: A pathologists' dilemma. ( 25861206 )
2015
8
Analysis of MDM2 Amplification in 43 Endometrial Stromal Tumors: A Potential Diagnostic Pitfall. ( 26444253 )
2015
9
Colonic low-grade endometrial stromal sarcoma and orthotopic endometrial stromal tumor with limited infiltration sharing the JAZF1-SUZ12 gene fusion. ( 24750188 )
2014
10
Malignant potential of endometrial stromal tumor with limited infiltration: a case report. ( 24155223 )
2014
11
Diagnosis of endometrial stromal tumors: a clinicopathologic study of 25 biopsy specimens with identification of problematic areas. ( 24343747 )
2014
12
Clinical characteristics, pathological reevaluation, surgical management and adjuvant therapy of patients with endometrial stromal tumors. ( 24981048 )
2014
13
Endometrial stromal tumors: the new WHO classification. ( 25299308 )
2014
14
Transgelin, a Novel Marker of Smooth Muscle Differentiation, Effectively Distinguishes Endometrial Stromal Tumors from Uterine Smooth Muscle Tumors. ( 26023684 )
2014
15
Endometrial stromal tumors: immunohistochemical and molecular analysis of potential targets of tyrosine kinase inhibitors. ( 23497641 )
2013
16
A well circumscribed uterine endometrial stromal tumor with smooth muscle differentiation recurred as a low grade endometrial stromal sarcoma: is tumor margin enough for the diagnosis? ( 22524669 )
2012
17
Outcome and prognostic factors in endometrial stromal tumors: a Rare Cancer Network study. ( 22300565 )
2012
18
Tumor dissemination after laparoscopic surgery for an unsuspected endometrial stromal tumor. ( 21797138 )
2011
19
Cytogenetic and molecular aberrations in endometrial stromal tumors. ( 21420714 )
2011
20
Frequency of known gene rearrangements in endometrial stromal tumors. ( 21836477 )
2011
21
Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas. ( 19898427 )
2010
22
Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors. ( 19542872 )
2009
23
Diagnostic use of nuclear beta-catenin expression for the assessment of endometrial stromal tumors. ( 18376386 )
2008
24
High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by interphase FISH detection. ( 17667554 )
2007
25
Meningothelial-like nodules: additional pattern of myoid differentiation in endometrial stromal tumors. ( 17685938 )
2007
26
Endometrial stromal tumor with limited infiltration and probable extrauterine metastasis: report of a case. ( 15692954 )
2005
27
An endometrial stromal tumor with osteoclast-like giant cells. ( 15944960 )
2005
28
Unusual morphologic features of endometrial stromal tumors: a report of 2 cases. ( 16160484 )
2005
29
Recurrent endometrial stromal tumors with smooth-muscle differentiation and a protracted clinical course. ( 16270099 )
2005
30
Endometrial stromal nodules and endometrial stromal tumors with limited infiltration: a clinicopathologic study of 50 cases. ( 11979087 )
2002
31
h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors. ( 11257619 )
2001
32
Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. ( 11371647 )
2001
33
Endometrial stromal tumors: an update on a group of tumors with a protean phenotype. ( 10976906 )
2000
34
Myxoid and fibrous endometrial stromal tumors of the uterus: a report of 10 cases. ( 10542938 )
1999
35
Role of electron microscopy in metastatic endometrial stromal tumors. ( 8266599 )
1993
36
Histologic and immunohistochemical analysis of nine endometrial stromal tumors: an unexpected high frequency of keratin protein positivity. ( 1709624 )
1991
37
Treatment of endometrial stromal tumors. ( 2295453 )
1990
38
Uterine tumor resembling an ovarian sex-cord tumor: report of a case of an endometrial stromal tumor with foam cells and ultrastructural evidence of epithelial differentiation. ( 4086162 )
1985
39
Endometrial stromal tumors, their varied radiographic patterns. ( 7233641 )
1980
40
Endometrial stromal tumor in a chimpanzee. ( 1166571 )
1975
41
Mesenchymal tumors of the uterus. I. A clinical and pathological study of 53 endometrial stromal tumors. ( 5939046 )
1966

Variations for Endometrial Stromal Tumor

Expression for Endometrial Stromal Tumor

Search GEO for disease gene expression data for Endometrial Stromal Tumor.

Pathways for Endometrial Stromal Tumor

Pathways related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.33 BCOR ESR1 YWHAE

GO Terms for Endometrial Stromal Tumor

Cellular components related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.4 BCOR ESR1 JAZF1 MEAF6 PGR PHF1
2 ESC/E(Z) complex GO:0035098 8.96 PHF1 SUZ12

Biological processes related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 posttranscriptional regulation of gene expression GO:0010608 9.16 ZC3H7A ZC3H7B
2 chromatin organization GO:0006325 9.02 BCOR MEAF6 PHF1 SMARCA1 SUZ12
3 production of miRNAs involved in gene silencing by miRNA GO:0035196 8.96 ZC3H7A ZC3H7B

Molecular functions related to Endometrial Stromal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.28 ESR1 JAZF1 MME PGR PHF1 POLI
2 miRNA binding GO:0035198 9.26 ZC3H7A ZC3H7B
3 steroid binding GO:0005496 9.16 ESR1 PGR
4 nucleosome binding GO:0031491 8.96 PHF1 SMARCA1

Sources for Endometrial Stromal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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