MCID: END002
MIFTS: 37

Endometrioid Ovary Carcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Endometrioid Ovary Carcinoma

MalaCards integrated aliases for Endometrioid Ovary Carcinoma:

Name: Endometrioid Ovary Carcinoma 12 15
Malignant Ovarian Endometrioid Tumor 12 73
Endometrioid Carcinoma of Ovary 12 59
Endometrioid Carcinoma Ovary 12 73
Ovarian Endometrioid Carcinoma 12
Endometrioid Neoplasm of Ovary 12
Ovarian Endometrioid Neoplasm 12
Ovarian Endometrial Cancer 12
Ovarian Endometrioid Tumor 73

Characteristics:

Orphanet epidemiological data:

59
endometrioid carcinoma of ovary
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Korea, Republic of),1-9/1000000 (Europe); Age of onset: Adult,Elderly; Age of death: adult,elderly;

Classifications:



External Ids:

Disease Ontology 12 DOID:5828 DOID:6212
Orphanet 59 ORPHA454723
UMLS via Orphanet 74 C0346163
ICD10 via Orphanet 34 C56

Summaries for Endometrioid Ovary Carcinoma

Disease Ontology : 12 An ovary epithelial cancer that has material basis in the endometrium and is located in the ovary.

MalaCards based summary : Endometrioid Ovary Carcinoma, also known as malignant ovarian endometrioid tumor, is related to ovarian clear cell carcinoma and ovarian serous carcinoma. An important gene associated with Endometrioid Ovary Carcinoma is MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1), and among its related pathways/superpathways are Mitotic G1-G1/S phases and Nuclear Events (kinase and transcription factor activation). Affiliated tissues include the ovary and ovary.

Related Diseases for Endometrioid Ovary Carcinoma

Diseases related to Endometrioid Ovary Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell carcinoma 29.8 ARID1A PPP2R1A
2 ovarian serous carcinoma 10.1
3 uterine body mixed cancer 10.0 ARID1A PPP2R1A
4 endodermal sinus tumor 10.0
5 adenomyoma 10.0
6 endometriosis 10.0
7 lynch syndrome 10.0
8 atypical polypoid adenomyoma 10.0
9 pseudo-meigs syndrome 10.0
10 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.0 ARID1A PPP2R1A
11 ovary adenocarcinoma 10.0 ARID1A POLE
12 hereditary wilms' tumor 9.9 PPP2R1A PPP2R1B
13 ischemic retinopathy 9.8 PLXND1 SEMA3E
14 uterine carcinosarcoma 9.8 POLE PPP2R1A

Graphical network of the top 20 diseases related to Endometrioid Ovary Carcinoma:



Diseases related to Endometrioid Ovary Carcinoma

Symptoms & Phenotypes for Endometrioid Ovary Carcinoma

Drugs & Therapeutics for Endometrioid Ovary Carcinoma

Search Clinical Trials , NIH Clinical Center for Endometrioid Ovary Carcinoma

Genetic Tests for Endometrioid Ovary Carcinoma

Anatomical Context for Endometrioid Ovary Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrioid Ovary Carcinoma:

19
The Ovary

MalaCards organs/tissues related to Endometrioid Ovary Carcinoma:

41
Ovary

Publications for Endometrioid Ovary Carcinoma

Articles related to Endometrioid Ovary Carcinoma:

(show all 12)
# Title Authors Year
1
Molecular-based classification algorithm for endometrial carcinoma categorizes ovarian endometrioid carcinoma into prognostically significant groups. ( 28776572 )
2017
2
Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas. ( 26799366 )
2016
3
Ovarian endometrioid carcinoma with yolk sac tumor component in a postmenopausal woman. ( 29943939 )
2016
4
Polymerase Epsilon Exonuclease Domain Mutations in Ovarian Endometrioid Carcinoma. ( 26166557 )
2015
5
A rare case of synchronous right ovarian clear cell carcinoma and an incidental left ovarian endometrioid carcinoma with immunohistochemical study. ( 24970988 )
2014
6
Frequent POLE1 p.S297F mutation in Chinese patients with ovarian endometrioid carcinoma. ( 24472300 )
2014
7
Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma. ( 19967725 )
2010
8
Re: Madore et al. Characterization of the molecular differences between ovarian endometrioid carcinoma and ovarian serous carcinoma. J Pathol 2010;220:392-400. ( 20572050 )
2010
9
Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma. ( 20003326 )
2009
10
Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma. ( 17952116 )
2008
11
Frameshift mutations in the bax gene are not involved in development of ovarian endometrioid carcinoma. ( 14559989 )
2003
12
Uterine atypical polypoid adenomyoma and ovarian endometrioid carcinoma: metastatic disease or dual primaries? ( 7883432 )
1995

Variations for Endometrioid Ovary Carcinoma

Cosmic variations for Endometrioid Ovary Carcinoma:

9 (show top 50) (show all 254)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44837 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.556G>C p.D186H 17:7675056-7675056 14
2 COSM43878 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.427G>A p.V143M 17:7675185-7675185 14
3 COSM43947 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.614A>G p.Y205C 17:7674917-7674917 14
4 COSM44935 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.724T>A p.C242S 17:7674239-7674239 14
5 COSM10758 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.659A>G p.Y220C 17:7674872-7674872 14
6 COSM10648 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.524G>A p.R175H 17:7675088-7675088 14
7 COSM43568 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.772G>T p.E258* 17:7674191-7674191 14
8 COSM10654 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.637C>T p.R213* 17:7674894-7674894 14
9 COSM46278 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.950A>G p.Q317R 17:7673578-7673578 14
10 COSM44321 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.712T>C p.C238R 17:7674251-7674251 14
11 COSM11089 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.584T>C p.I195T 17:7674947-7674947 14
12 COSM44890 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.770T>G p.L257R 17:7674193-7674193 14
13 COSM11582 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.395A>G p.K132R 17:7675217-7675217 14
14 COSM43650 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.638G>T p.R213L 17:7674893-7674893 14
15 COSM10808 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.488A>G p.Y163C 17:7675124-7675124 14
16 COSM10742 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.578A>G p.H193R 17:7674953-7674953 14
17 COSM45672 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.376-2A>G p.? 17:7675238-7675238 14
18 COSM11354 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.991C>T p.Q331* 17:7673537-7673537 14
19 COSM10774 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.960G>C p.K320N 17:7673568-7673568 14
20 COSM11501 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.823T>G p.C275G 17:7673797-7673797 14
21 COSM10812 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.722C>T p.S241F 17:7674241-7674241 14
22 COSM11063 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.711G>T p.M237I 17:7674252-7674252 14
23 COSM6932 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.733G>A p.G245S 17:7674230-7674230 14
24 COSM44171 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.840A>T p.R280S 17:7673780-7673780 14
25 COSM11224 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.394A>C p.K132Q 17:7675218-7675218 14
26 COSM44413 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.484A>G p.I162V 17:7675128-7675128 14
27 COSM10659 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.817C>T p.R273C 17:7673803-7673803 14
28 COSM43651 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.763A>T p.I255F 17:7674200-7674200 14
29 COSM44204 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.423C>G p.C141W 17:7675189-7675189 14
30 COSM10995 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.580C>T p.L194F 17:7674951-7674951 14
31 COSM10943 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.841G>C p.D281H 17:7673779-7673779 14
32 COSM10731 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.707A>G p.Y236C 17:7674256-7674256 14
33 COSM43571 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.782+1G>A p.? 17:7674180-7674180 14
34 COSM10646 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.725G>A p.C242Y 17:7674238-7674238 14
35 COSM43920 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.680C>T p.S227F 17:7674283-7674283 14
36 COSM10779 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.818G>T p.R273L 17:7673802-7673802 14
37 COSM10810 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.725G>T p.C242F 17:7674238-7674238 14
38 COSM43837 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.843C>G p.D281E 17:7673777-7673777 14
39 COSM44226 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.380C>T p.S127F 17:7675232-7675232 14
40 COSM11059 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.713G>A p.C238Y 17:7674250-7674250 14
41 COSM10701 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.824G>T p.C275F 17:7673796-7673796 14
42 COSM6906 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.672+1G>A p.? 17:7674858-7674858 14
43 COSM46397 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.375+2T>A p.? 17:7675992-7675992 14
44 COSM10656 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.742C>T p.R248W 17:7674221-7674221 14
45 COSM46475 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.945T>G p.S315S 17:7673583-7673583 14
46 COSM11392 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.800G>C p.R267P 17:7673820-7673820 14
47 COSM46166 TP53 ovary,NS,carcinoma,endometrioid carcinoma c.872A>T p.K291M 17:7673748-7673748 14
48 COSM20647 TNK2 ovary,NS,carcinoma,endometrioid carcinoma c.1036G>A p.E346K 3:195878571-195878571 14
49 COSM1100526 SOX17 ovary,NS,carcinoma,endometrioid carcinoma c.1208G>T p.S403I 8:54459958-54459958 14
50 COSM5575285 RAD51 ovary,NS,carcinoma,endometrioid carcinoma c.88C>T p.Q30* 15:40701064-40701064 14

Expression for Endometrioid Ovary Carcinoma

Search GEO for disease gene expression data for Endometrioid Ovary Carcinoma.

Pathways for Endometrioid Ovary Carcinoma

Pathways related to Endometrioid Ovary Carcinoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.95 POLE PPP2R1A PPP2R1B
2
Show member pathways
11.52 PPP2R1A PPP2R1B
3 11.47 PPP2R1A PPP2R1B
4
Show member pathways
11.45 PPP2R1A PPP2R1B
5 11.4 PPP2R1A PPP2R1B
6
Show member pathways
11.32 PPP2R1A PPP2R1B
7 11.28 PPP2R1A PPP2R1B
8
Show member pathways
11.22 PPP2R1A PPP2R1B
9
Show member pathways
11.17 POLE PPP2R1A PPP2R1B
10 11.15 PPP2R1A PPP2R1B
11 11.05 PPP2R1A PPP2R1B
12 10.71 PPP2R1A PPP2R1B
13
Show member pathways
10.5 PPP2R1A PPP2R1B

GO Terms for Endometrioid Ovary Carcinoma

Cellular components related to Endometrioid Ovary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphatase type 2A complex GO:0000159 8.62 PPP2R1A PPP2R1B

Biological processes related to Endometrioid Ovary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of phosphoprotein phosphatase activity GO:0043666 9.26 PPP2R1A PPP2R1B
2 semaphorin-plexin signaling pathway GO:0071526 9.16 PLXND1 SEMA3E
3 branching involved in blood vessel morphogenesis GO:0001569 8.96 PLXND1 SEMA3E
4 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 8.62 PPP2R1A PPP2R1B

Molecular functions related to Endometrioid Ovary Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein serine/threonine phosphatase activity GO:0004722 8.96 PPP2R1A PPP2R1B
2 protein phosphatase regulator activity GO:0019888 8.62 PPP2R1A PPP2R1B

Sources for Endometrioid Ovary Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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