MCID: END044
MIFTS: 65

Endometriosis

Categories: Gastrointestinal diseases, Nephrological diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Endometriosis

MalaCards integrated aliases for Endometriosis:

Name: Endometriosis 12 77 38 30 56 44 45 15 64 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:289
KEGG 38 H01639
ICD9CM 36 617 617.9
MeSH 45 D004715
NCIt 51 C3014
SNOMED-CT 69 11871002
ICD10 34 N80 N80.9
UMLS 74 C0014175

Summaries for Endometriosis

MedlinePlus : 44 What is endometriosis? The uterus, or womb, is the place where a baby grows when a woman is pregnant. It is lined with tissue (endometrium). Endometriosis is a disease in which tissue that is similar to the lining of the uterus grows in other places in your body. These patches of tissue are called "implants," "nodules," or "lesions." They are most often found On or under the ovaries On the fallopian tubes, which carry egg cells from the ovaries to the uterus Behind the uterus On the tissues that hold the uterus in place On the bowels or bladder In rare cases, the tissue may grow on your lungs or in other parts of your body. What causes endometriosis? Researchers don't know what causes endometriosis. Who is at risk for endometriosis? Endometriosis is most commonly diagnosed in women in their 30s and 40s. But it can affect any female who menstruates. Certain factors can raise or lower your risk of getting it. You are at higher risk if You have a mother, sister, or daughter with endometriosis Your period started before age 11 Your monthly cycles are short (less than 27 days) Your menstrual cycles are heavy and last more than 7 days You have a lower risk if You have been pregnant before Your periods started late in adolescence You regularly exercise more than 4 hours a week You have a low amount of body fat What are the symptoms of endometriosis? The main symptoms of endometriosis are Pelvic pain, which affects about 75 percent of women with endometriosis. It often happens during your period. Infertility, which affects up to half of all women with endometriosis Other possible symptoms include Painful menstrual cramps, which may get worse over time Pain during or after sex Pain in the intestine or lower abdomen Pain with bowel movements or urination, usually during your period Heavy periods Spotting or bleeding between periods Digestive or gastrointestinal symptoms Fatigue or lack of energy How is endometriosis diagnosed? Surgery is the only way to know for sure that you have endometriosis. First, however, your health care provider will ask about your symptoms and medical history. You will have a pelvic exam and may have some imaging tests. The surgery to diagnose endometriosis is a laparoscopy. This is a type of surgery that uses a laparoscope, a thin tube with a camera and light. The surgeon inserts the laparoscope through a small cut in the skin. Your provider can make a diagnosis based on how the patches of endometriosis look. He or she may also do a biopsy to get a tissue sample. What are the treatments for endometriosis? There is no cure for endometriosis, but there are treatments for the symptoms. Your health care provider will work with you to decide which treatments would be best for you. Treatments for endometriosis pain include Pain relievers, including nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen and a prescription medicine specifically for endometriosis. Providers may sometimes prescribe opioids for severe pain. Hormone therapy, including birth control pills, progestin therapy, and gonadotropin-releasing hormone (GnRH) agonists. GnRH agonists cause a temporary menopause, but also help control the growth of endometriosis. Surgical treatments for severe pain, including procedures to remove the endometriosis patches or cut some nerves in the pelvis. The surgery may be a laparoscopy or major surgery. The pain may come back within a few years after surgery. If the pain is very severe, a hysterectomy may be an option. This is a surgery to remove the uterus. Sometimes providers also remove the ovaries and fallopian tubes as part of a hysterectomy. Treatments for infertility caused by endometriosis include Laparoscopy to remove the endometriosis patches In vitro fertilization NIH: National Institute of Child Health and Human Development

MalaCards based summary : Endometriosis is related to leiomyoma, uterine and coronary heart disease 1, and has symptoms including pelvic pain and pain and other symptoms associated with female genital organs. An important gene associated with Endometriosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors. The drugs Tibolone and Calcium Carbonate have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and endothelial.

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.

PubMed Health : 64 About endometriosis: Endometriosis is one of the most common medical conditions affecting the abdomen (lower belly) in women. In endometriosis, the kind of tissue that normally lines the inside of the womb (endometrial tissue) also grows outside of it. The medical term for endometrial tissue that has grown outside of the womb is “endometrial implants.” Some women have them without knowing it. But other women experience endometriosis as a chronic disease that causes severe pain and fertility problems. It often takes years for endometriosis to be diagnosed as the cause of these problems. Until the diagnosis is made, many women try to cope with their pain somehow. They believe that the pain – even really bad pain – is a normal part of their menstrual period.There is currently no cure for endometriosis. But there are many things that can be done to relieve the symptoms. If treatment is adapted to suit women’s personal circumstances and the severity of their endometriosis, many can cope quite well with the disease.Like with other chronic conditions, it's important to get to know your own body and how it reacts, in order to find ways to manage the symptoms. Getting hold of good information and consulting experienced, supportive doctors can help.

Wikipedia : 77 Endometriosis is a condition in which cells similar to those in the endometrium, the layer of tissue... more...

Related Diseases for Endometriosis

Diseases in the Endometriosis family:

Endometriosis 1

Diseases related to Endometriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 353)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 30.1 MIR150 MIR196B MIR29C
2 coronary heart disease 1 29.8 CDKN2B-AS1 H19 MIR126 MIR145
3 cervical cancer 29.4 CDKN2B-AS1 H19 MIR143 MIR196B
4 melanoma 29.3 CDKN2B-AS1 H19 MIR141 MIR200A MIR200B
5 bladder cancer 29.1 CDKN2B-AS1 H19 MIR143 MIR145 MIR223 MIR29C
6 breast cancer 28.2 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
7 colorectal cancer 28.2 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
8 ovarian cancer 28.1 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
9 prostate cancer 27.2 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
10 lung cancer 26.9 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
11 endometriosis of ovary 12.7
12 extrapelvic endometriosis 12.4
13 fallopian tube endometriosis 12.4
14 adenomyosis 12.3
15 cervix endometriosis 12.3
16 endometriosis of intestine 12.2
17 endometriosis of pelvic peritoneum 12.2
18 endometriosis in scar of skin 12.2
19 endometriosis of rectovaginal septum and vagina 12.2
20 endometriosis 1 12.1
21 catamenial pneumothorax 11.7
22 adenosarcoma 11.6
23 pain - chronic 11.4
24 uterine anomalies 11.1
25 benign multicystic peritoneal mesothelioma 11.1
26 infertility 10.7
27 adenocarcinoma 10.6
28 pneumothorax 10.5
29 ureteral obstruction 10.4
30 sarcoma 10.4
31 intussusception 10.4
32 appendicitis 10.4
33 intestinal obstruction 10.4
34 endometrial stromal sarcoma 10.4
35 clear cell adenocarcinoma 10.4
36 mullerian aplasia 10.4 H19 WNT4
37 ovarian cancer 1 10.3
38 ovarian clear cell carcinoma 10.3
39 hypoxia 10.3
40 hydronephrosis 10.2
41 endometrial cancer 10.2
42 pelvic inflammatory disease 10.2
43 leiomyomatosis 10.2
44 intravenous leiomyomatosis 10.2
45 ectopic pregnancy 10.2
46 leiomyoma 10.2
47 ovarian epithelial cancer 10.2
48 progesterone resistance 10.2
49 diffuse peritoneal leiomyomatosis 10.2
50 esophagus adenocarcinoma 10.2 MIR143 MIR145

Comorbidity relations with Endometriosis via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to Endometriosis

Symptoms & Phenotypes for Endometriosis

UMLS symptoms related to Endometriosis:


pelvic pain, pain and other symptoms associated with female genital organs

Drugs & Therapeutics for Endometriosis

PubMedHealth treatment related to Endometriosis: 64

There is currently no “cure” for endometriosis – in other words, there are no treatments that can fight what is causing it. But various treatments can help relieve the symptoms, temporarily or permanently. The medication options include painkillers, hormonal contraception and stronger hormone therapy. Painkillers only relieve the symptoms, whereas hormone-based treatments slow down the growth of endometrial implants.Surgery is also an option. The aim of surgery for endometriosis is usually to remove as many endometrial implants as possible. Sometimes surgery is even necessary – for instance, if endometriosis is affecting bowel or bladder function.

Drugs for Endometriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 301)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tibolone Approved, Investigational Phase 4 5630-53-5
2
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
3
Goserelin Approved Phase 4,Phase 3,Not Applicable 65807-02-5 5311128 47725
4
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-83-0 5994
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Not Applicable 28014-46-2
7
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-28-2 5757
8
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Not Applicable 57-63-6 5991
9
Drospirenone Approved Phase 4,Phase 3,Phase 2 67392-87-4 68873
10
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
11
Norgestrel Approved Phase 4 6533-00-2 13109
12
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 360-70-3 9677
13
Dienogest Approved Phase 4,Phase 3,Phase 2,Not Applicable 65928-58-7
14
Nandrolone phenpropionate Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 62-90-8 229455
15
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53714-56-0 657181 3911
16
Sodium Citrate Approved, Investigational Phase 4,Not Applicable 68-04-2
17
Sage Approved Phase 4
18
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1 120511-73-1 2187
19
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
20
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 6917715 40976
21
Desogestrel Approved Phase 4,Not Applicable 54024-22-5 40973
22
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 1 71-58-9
23
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
24
Danazol Approved Phase 4,Phase 2 17230-88-5 28417
25
Quinagolide Approved, Investigational Phase 4,Phase 2 87056-78-8, 97805-50-0 105105
26
Dopamine Approved Phase 4,Phase 2 62-31-7, 51-61-6 681
27
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
28
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
29
tannic acid Approved Phase 4 1401-55-4
30
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
31
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
32
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
33
Norepinephrine Approved Phase 4 51-41-2 439260
34
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
35
Calcium Approved, Nutraceutical Phase 4,Not Applicable 7440-70-2 271
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
37
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
38
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
39 Gallopamil Investigational Phase 4 16662-47-8
40
Nandrolone Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 434-22-0 9904
41 Deslorelin Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57773-65-6
42
Enclomiphene Investigational Phase 4,Not Applicable 15690-57-0
43
Gestodene Investigational Phase 4,Not Applicable 60282-87-3 3033968
44 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Vitamins Phase 4,Phase 2
46 Calciferol Phase 4
47 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
49 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
50 Nutrients Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 429)
# Name Status NCT ID Phase Drugs
1 Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis Unknown status NCT00654524 Phase 4 gonadotropin-releasing-hormone agonist (GnRHa) - Goserelin
2 Ulipristal for Endometriosis-related Pelvic Pain Unknown status NCT02213081 Phase 4 Ulipristal
3 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
4 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4 Continuous OC (clormadinone acetate plus ethinil-estradiol - Belara®, Grunenthal, Milan, Italy);Cyclic OC (clormadinone acetate plus ethinil-estradiol)
5 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4 Sanjie analgesic capsule;placebo
6 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
7 Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery Unknown status NCT02385448 Phase 4 Dienogest;Microgynon
8 Supplementation in Adolescent Girls With Endometriosis Completed NCT02387931 Phase 4
9 Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence Completed NCT01769781 Phase 4 anastrazole;GnRH analog alone
10 Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis Completed NCT02158845 Phase 4 LNG-IUS: levonorgestrel intrauterine system;GnRHa: leuprolide
11 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed NCT01682642 Phase 4 Zoladex
12 Homeopathic Treatment of Chronic Pelvic Pain in Women With Endometriosis Completed NCT02427386 Phase 4 dynamized estrogen;placebo
13 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Completed NCT02480647 Phase 4 Levonorgestrel;Etonogestrel
14 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4 Leuprolide acetate in depot suspension;Leuprolide acetate;leuprolide acetate
15 The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis Completed NCT01581359 Phase 4 Triptorelin acetate
16 Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain Completed NCT01056042 Phase 4 intramuscular depot medroxyprogesterone acetate;ethinyl estradiol 30 micrograms, gestodene 75 micrograms
17 Resveratrol for Pain Due to Endometriosis Completed NCT02475564 Phase 4 Placebo;Resveratrol
18 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4 Danazol;placebo
19 Endometriosis Patients Undergoing Quinagolide Treatment Completed NCT00625950 Phase 4
20 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
21 Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients Completed NCT02534688 Phase 4 LNG-IUS;DMPA
22 Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women Completed NCT00735852 Phase 4 Decapeptyl SR 11.25mg
23 Understanding Experimentally Induced Hot Flushes Completed NCT00455689 Phase 4 Leuprolide acetate
24 Impact of Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
25 Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving Recruiting NCT03080558 Phase 4 Indocyanine green
26 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest Recruiting NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
27 Effects of Dienogest and Dienogest Plus Estradiol Valerate in Ovarian Endometrioma Recruiting NCT03789123 Phase 4 Estradiol valerate/dienogest
28 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
29 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
30 Psychological Impact of Amenorrhea in Women With Endometriosis Not yet recruiting NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
31 The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation Not yet recruiting NCT03809221 Phase 4 Triptorelin acetate
32 Trans-vaginal Aspiration of Small Ovarian Endometrioma. Comparison of Two Different Techniques Before ICSI Not yet recruiting NCT03784404 Phase 4 Intracytoplasmic sperm injection
33 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4 Combined Oral Contraceptive Pill (Microgynon 30)
34 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
35 Duloxetine for the Treatment of Chronic Pelvic Pain Terminated NCT01451606 Phase 4 Duloxetine;Placebo
36 Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery Unknown status NCT01125488 Phase 3 GnRH agonist (triptorelin)
37 Subcutaneous Progesterone Supplementation in Patients With Endometriosis Unknown status NCT02793908 Phase 3 Pleyris;Crinone8
38 Efficacy of Trace Elements in the Treatment of Endometriosis: a Pilot Study Unknown status NCT02437175 Phase 3
39 Laparoscopy Versus Laparotomy for Colorectal Endometriosis Unknown status NCT00939861 Phase 3
40 Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) Unknown status NCT00458458 Phase 3 Norethindrone Acetate (NA);GnRH Agonist (Lupron Depot)
41 Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Women With Endometriosis Unknown status NCT02470169 Phase 3 Merional;Choriomon
42 The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study Unknown status NCT00894946 Phase 3
43 The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol Unknown status NCT01636505 Phase 3 ghrh antagonist (cetrotide/orgalutran);gnrh agonist (suprefact)
44 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain Completed NCT02143713 Phase 3 Elagolix
45 Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients Completed NCT01822080 Phase 3 Dienogest (Visanne, BAY86-5258);Placebo
46 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain Completed NCT01760954 Phase 3 Elagolix
47 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01931670 Phase 3 Elagolix
48 Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis Completed NCT02271958 Phase 2, Phase 3 Mifepristone;PLACEBO
49 Degarelix in the Treatment of Endometriosis Recurrence Completed NCT01712763 Phase 3 degarelix;goserelin
50 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01620528 Phase 3 elagolix

Search NIH Clinical Center for Endometriosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: endometriosis

Genetic Tests for Endometriosis

Genetic tests related to Endometriosis:

# Genetic test Affiliating Genes
1 Endometriosis 30

Anatomical Context for Endometriosis

MalaCards organs/tissues related to Endometriosis:

42
Uterus, Ovary, Endothelial, Colon, Testes, Appendix, Skin

Publications for Endometriosis

Articles related to Endometriosis:

(show top 50) (show all 5712)
# Title Authors Year
1
Expression and role of hScrib in endometrium, endometriosis, and endometrial adenocarcinoma. ( 30702562 )
2019
2
Laparoscopic posterior pelvic exenteration for primary adenocarcinoma of the rectovaginal septum without associated endometriosis: A case report. ( 30680193 )
2019
3
Incidental Detection of Endometriosis with 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography in a Patient with Cervical Intraepithelial Neoplasia and Adenomyosis. ( 31040534 )
2019
4
Peritoneal endometriosis induces time-related depressive- and anxiety-like alterations in female rats: involvement of hippocampal pro-oxidative and BDNF alterations. ( 30798429 )
2019
5
A cohort study of 49 933 women with surgically verified endometriosis - increased incidence of breast cancer below the age of 40. ( 30883685 )
2019
6
Machine Learning Approach to find the relation between Endometriosis, benign breast disease, cystitis and non-toxic goiter. ( 30932000 )
2019
7
Baseline severe constipation negatively impacts functional outcomes of surgery for deep endometriosis infiltrating the rectum: results of the ENDORE randomized trial. ( 30902761 )
2019
8
Extrauterine, Extragenital Endometrial Stromal Sarcoma in the Absence of Endometriosis: A Rare Entity. ( 29210799 )
2019
9
Study of possible association between endometriosis and phthalate and bisphenol A by biomarkers analysis. ( 31063881 )
2019
10
Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis. ( 31064924 )
2019
11
Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis. ( 31064958 )
2019
12
Effects of omega-6/3 and omega-9/6 nutraceuticals on pain and fertility in peritoneal endometriosis in rats. ( 31066787 )
2019
13
Hormone treatment as first line therapy is safe and relieves pelvic pain in women with bowel endometriosis. ( 31066795 )
2019
14
Efficacy and safety of ASP1707 for endometriosis-associated pelvic pain: the phase II randomized controlled TERRA study. ( 31067329 )
2019
15
Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment. ( 31069056 )
2019
16
Potential roles of aquaporin 9 in the pathogenesis of endometriosis. ( 31070762 )
2019
17
Future directions in endometriosis treatment: discovery and development of novel inhibitors of estrogen biosynthesis. ( 31072144 )
2019
18
Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer. ( 31074246 )
2019
19
C-reactive protein assessment to predict early septic complications after laparoscopic bowel resection for endometriosis: a diagnostic study. ( 31077531 )
2019
20
Transforming growth factor β (TGF-β): is there a different role with regard to distinct phenotypes of endometriosis? ( 31077692 )
2019
21
Endometriosis of the Appendix. ( 31077836 )
2019
22
The effect of concurrent endometriosis on the prognosis of women with ovarian clear cell or endometrioid carcinoma. ( 31081117 )
2019
23
Psychological interventions for endometriosis-related symptoms: a systematic review with narrative data synthesis. ( 31081520 )
2019
24
Pragmatic clinical diagnosis and management of endometriosis. ( 31082386 )
2019
25
Computed Tomography-Colonography With Intravenous Contrast Medium and Urographic Phase for the Evaluation of Pelvic Deep Infiltrating Endometriosis of Intestinal and Urinary Tract. ( 31082957 )
2019
26
Computed Tomography-Colonography With Intravenous Contrast Medium and Urographic Phase for the Evaluation of Pelvic Deep Infiltrating Endometriosis of Intestinal and Urinary Tract. ( 31082981 )
2019
27
Patterns of Prescription Opioid Use in Women With Endometriosis: Evaluating Prolonged Use, Daily Dose, and Concomitant Use With Benzodiazepines. ( 31083112 )
2019
28
Endometriosis presenting with recurrent massive hemorrhagic ascites and diagnosed by core needle biopsy: A case report. ( 31083181 )
2019
29
Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis. ( 31087436 )
2019
30
The Endometriosis Impact Questionnaire (EIQ): a tool to measure the long-term impact of endometriosis on different aspects of women's lives. ( 31088434 )
2019
31
Ethiopathogenic mechanisms of endometriosis-related infertility. ( 31091056 )
2019
32
Abdominal Wall Endometriosis in an Abdominoplasty Patient. ( 31093711 )
2019
33
Effectiveness of dienogest in improving quality of life in Asian women with endometriosis (ENVISIOeN): interim results from a prospective cohort study under real-life clinical practice. ( 31096979 )
2019
34
Elevated serum interleukin-32 levels in patients with endometriosis: A cross-sectional study. ( 31099938 )
2019
35
LINC00261 functions as a competing endogenous RNA to regulate BCL2L11 expression by sponging miR-132-3p in endometriosis. ( 31105834 )
2019
36
Epigenetic role of the nuclear factor NF-Y on ID gene family in endometrial tissues of women with endometriosis: a case control study. ( 30876429 )
2019
37
TGR5 agonist INT-777 mitigates inflammatory response in human endometriotic stromal cells: A therapeutic implication for endometriosis. ( 30878820 )
2019
38
Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis. ( 30882467 )
2019
39
Noninvasive Monitoring of Lesion Size in a Heterologous Mouse Model of Endometriosis. ( 30882775 )
2019
40
AC002454.1 and CDK6 synergistically promote Endometrial Cell Migration and Invasion in Endometriosis. ( 30884467 )
2019
41
Identifying Preoperative Factors Associated with Nonresponders in Women Undergoing Comprehensive Surgical Treatment for Endometriosis. ( 30885782 )
2019
42
Genesis, genes and epigenetics of endometriosis-associated infertility. ( 30886366 )
2019
43
Influence of STAT4 gene polymorphisms in the pathogenesis of endometriosis. ( 30887509 )
2019
44
Effects of clarithromycin on inflammatory markers and clinical manifestations in postsurgical follow-up of patients with endometriosis: a double-blinded randomized placebo-controlled clinical trial. ( 30888478 )
2019
45
Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis. ( 30888523 )
2019
46
Endometriosis of the Bladder: Clinical and Surgical Outcomes after Laparoscopic Surgery. ( 30888677 )
2019
47
Continuous oral contraceptives versus long-term pituitary desensitization prior to IVF/ICSI in moderate to severe endometriosis: study protocol of a non-inferiority randomized controlled trial. ( 30895266 )
2019
48
Non-traumatic diaphragmatic rupture with liver herniation due to endometriosis : a rare evolution of the disease requiring multidisciplinary management. ( 30898626 )
2019
49
Rectal perforation caused by deep infiltrating endometriosis in non-pregnant woman: Case report and short review of the literature. ( 30898991 )
2019
50
Diagnosis of endometriosis in the 21st century. ( 30905186 )
2019

Variations for Endometriosis

Expression for Endometriosis

LifeMap Discovery
Genes differentially expressed in tissues of Endometriosis patients vs. healthy controls: 35 (show top 50) (show all 83)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PTGIS prostaglandin I2 (prostacyclin) synthase Uterus + 5.41 0.000
2 MYH11 myosin, heavy chain 11, smooth muscle Uterus + 4.87 0.001
3 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide Uterus + 4.81 0.000
4 CNN1 calponin 1, basic, smooth muscle Uterus + 4.71 0.000
5 TAGLN transgelin Uterus + 4.63 0.000
6 PAEP progestagen-associated endometrial protein Uterus + 4.63 0.013
7 PRELP proline/arginine-rich end leucine-rich repeat protein Uterus + 4.59 0.000
8 C7 complement component 7 Uterus + 4.54 0.003
9 ACTG2 actin, gamma 2, smooth muscle, enteric Uterus + 4.48 0.003
10 TCF21 transcription factor 21 Uterus + 4.45 0.000
11 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 4.42 0.001
12 WISP2 WNT1 inducible signaling pathway protein 2 Uterus + 4.11 0.001
13 AQP1 aquaporin 1 (Colton blood group) Uterus + 4.10 0.000
14 EHF ets homologous factor Uterus - 4.10 0.000
15 FOS FBJ murine osteosarcoma viral oncogene homolog Uterus + 4.09 0.000
16 FOSB FBJ murine osteosarcoma viral oncogene homolog B Uterus + 4.07 0.000
17 SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 Uterus - 4.05 0.010
18 LMNB1 lamin B1 Uterus - 4.05 0.000
19 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.99 0.000
20 DPT dermatopontin Uterus + 3.98 0.000
21 DES desmin Uterus + 3.97 0.001
22 KCNMB1 potassium channel subfamily M regulatory beta subunit 1 Uterus + 3.96 0.001
23 GATA6 GATA binding protein 6 Uterus + 3.89 0.004
24 FZD7 frizzled class receptor 7 Uterus + 3.89 0.000
25 LEFTY2 left-right determination factor 2 Uterus + 3.88 0.001
26 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.87 0.001
27 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 3.86 0.001
28 ACKR1 atypical chemokine receptor 1 (Duffy blood group) Uterus + 3.84 0.001
29 EFHC2 EF-hand domain (C-terminal) containing 2 Uterus - 3.75 0.000
30 PDLIM3 PDZ and LIM domain 3 Uterus + 3.72 0.001
31 GPC3 glypican 3 Uterus + 3.71 0.003
32 IL20RA interleukin 20 receptor, alpha Uterus - 3.70 0.000
33 MYL9 myosin, light chain 9, regulatory Uterus + 3.70 0.001
34 VNN1 vanin 1 Uterus - 3.69 0.008
35 CTSZ cathepsin Z Uterus - 3.68 0.000
36 EHF ets homologous factor Uterus - 3.67 0.000
37 LMNB1 lamin B1 Uterus - 3.61 0.000
38 CLU clusterin Uterus + 3.58 0.002
39 ACTA2 actin, alpha 2, smooth muscle, aorta Uterus + 3.57 0.000
40 TCEAL2 transcription elongation factor A (SII)-like 2 Uterus + 3.53 0.001
41 LMOD1 leiomodin 1 (smooth muscle) Uterus + 3.52 0.003
42 LMO3 LIM domain only 3 (rhombotin-like 2) Uterus + 3.51 0.002
43 TPD52 tumor protein D52 Uterus - 3.50 0.000
44 SYNPO synaptopodin Uterus + 3.48 0.001
45 KLF2 Kruppel-like factor 2 Uterus + 3.44 0.000
46 AOC3 amine oxidase, copper containing 3 Uterus + 3.44 0.003
47 KCNK3 potassium channel, two pore domain subfamily K, member 3 Uterus + 3.44 0.007
48 ZBBX zinc finger, B-box domain containing Uterus - 3.43 0.001
49 FMO1 flavin containing monooxygenase 1 Uterus + 3.43 0.000
50 ZBBX zinc finger, B-box domain containing Uterus - 3.42 0.002
Search GEO for disease gene expression data for Endometriosis.

Pathways for Endometriosis

Pathways related to Endometriosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 MIR125A MIR126 MIR141 MIR143 MIR145 MIR150
2 10.77 MIR141 MIR200A MIR200B
3 10.11 MIR126 MIR150

GO Terms for Endometriosis

Cellular components related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 MIR125A MIR126 MIR141 MIR143 MIR150 MIR20A
2 micro-ribonucleoprotein complex GO:0035068 9.53 H19 MIR125A MIR126 MIR141 MIR143 MIR145

Biological processes related to Endometriosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.73 MIR126 MIR143 MIR20A MIR99B
2 negative regulation of inflammatory response GO:0050728 9.71 MIR126 MIR141 MIR20A
3 negative regulation of protein kinase B signaling GO:0051898 9.69 MIR145 MIR20A MIR29C
4 positive regulation of blood vessel endothelial cell migration GO:0043536 9.67 MIR126 MIR143 MIR200A
5 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.63 MIR20A MIR29C MIR424
6 negative regulation of gene expression GO:0010629 9.63 CDKN2B-AS1 MIR125A MIR200B MIR20A MIR29C WNT4
7 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.62 MIR126 MIR150
8 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.61 MIR145 MIR20A
9 negative regulation of smooth muscle cell proliferation GO:0048662 9.61 MIR143 MIR145
10 positive regulation of sprouting angiogenesis GO:1903672 9.6 MIR125A MIR126
11 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.59 MIR29C MIR424
12 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.58 MIR143 MIR20A
13 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.58 MIR223 MIR424
14 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 9.57 MIR424 WNT4
15 regulation of smooth muscle contraction GO:0006940 9.56 MIR143 MIR145
16 positive regulation of endothelial cell differentiation GO:0045603 9.55 MIR150 MIR99B
17 gene silencing by miRNA GO:0035195 9.53 H19 MIR125A MIR126 MIR141 MIR143 MIR145
18 angiotensin-activated signaling pathway GO:0038166 9.52 MIR143 MIR145
19 negative regulation of vascular endothelial cell proliferation GO:1905563 9.5 MIR126 MIR29C MIR424
20 aorta smooth muscle tissue morphogenesis GO:0060414 9.48 MIR143 MIR145
21 negative regulation of angiogenesis GO:0016525 9.43 MIR125A MIR143 MIR145 MIR200B MIR29C MIR424
22 regulation of phenotypic switching GO:1900239 9.4 MIR143 MIR145
23 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.37 MIR143 MIR20A
24 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.26 MIR143 MIR145

Molecular functions related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR125A MIR126 MIR141 MIR143 MIR145 MIR150
2 RNA polymerase II complex binding GO:0000993 9.26 MIR125A MIR126 MIR145 MIR20A

Sources for Endometriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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