MCID: END044
MIFTS: 65

Endometriosis

Categories: Nephrological diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Endometriosis

MalaCards integrated aliases for Endometriosis:

Name: Endometriosis 12 76 37 29 55 43 44 15 63 73

Classifications:



External Ids:

Disease Ontology 12 DOID:289
ICD10 33 N80 N80.9
ICD9CM 35 617 617.9
MeSH 44 D004715
NCIt 50 C3014
SNOMED-CT 68 11871002
KEGG 37 H01639
UMLS 73 C0014175

Summaries for Endometriosis

PubMed Health : 63 About endometriosis: Endometriosis is one of the most common medical conditions affecting the abdomen (lower belly) in women. In endometriosis, the kind of tissue that normally lines the inside of the womb (endometrial tissue) also grows outside of it. The medical term for endometrial tissue that has grown outside of the womb is “endometrial implants.” Some women have them without knowing it. But other women experience endometriosis as a chronic disease that causes severe pain and fertility problems. It often takes years for endometriosis to be diagnosed as the cause of these problems. Until the diagnosis is made, many women try to cope with their pain somehow. They believe that the pain – even really bad pain – is a normal part of their menstrual period.There is currently no cure for endometriosis. But there are many things that can be done to relieve the symptoms. If treatment is adapted to suit women’s personal circumstances and the severity of their endometriosis, many can cope quite well with the disease.Like with other chronic conditions, it's important to get to know your own body and how it reacts, in order to find ways to manage the symptoms. Getting hold of good information and consulting experienced, supportive doctors can help.

MalaCards based summary : Endometriosis is related to leiomyoma, uterine and cervical cancer, and has symptoms including pelvic pain and pain and other symptoms associated with female genital organs. An important gene associated with Endometriosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are MicroRNAs in cancer and miRNA targets in ECM and membrane receptors. The drugs Goserelin and Tibolone have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and endothelial.

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.

MedlinePlus : 43 The uterus, or womb, is the place where a baby grows when a woman is pregnant. Endometriosis is a disease in which the kind of tissue that normally grows inside the uterus grows outside the uterus. It can grow on the ovaries, fallopian tubes, bowels, or bladder. Rarely, it grows in other parts of the body. Symptoms include Pain, usually in the abdomen, lower back, or pelvic areas Infertility Heavy periods and bleeding between periods Painful menstrual cramps Some women have no symptoms at all. Having trouble getting pregnant may be the first sign. The cause of endometriosis is not known. Surgery, usually a laparoscopy, is currently the only way to be sure that you have endometriosis. Your health care provider will first take your medical history, do a pelvic exam, and maybe do imaging tests. There is no cure, but treatments help with pain and infertility. They include pain medicines, hormone treatments, and surgery. NIH: National Institute of Child Health and Human Development

Wikipedia : 76 Endometriosis is a condition in which cells similar to those in the endometrium, the layer of tissue... more...

Related Diseases for Endometriosis

Diseases in the Endometriosis family:

Endometriosis 1

Diseases related to Endometriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 30.1 MIR150 MIR196B MIR29C
2 cervical cancer 29.3 CDKN2B-AS1 H19 MIR143 MIR196B
3 ovarian cancer 29.0 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
4 breast cancer 28.7 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
5 colorectal cancer 28.6 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
6 prostate cancer 28.0 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
7 lung cancer 27.8 CDKN2B-AS1 H19 MIR125A MIR126 MIR141 MIR143
8 endometriosis of ovary 12.6
9 extrapelvic endometriosis 12.4
10 fallopian tube endometriosis 12.3
11 adenomyosis 12.3
12 cervix endometriosis 12.3
13 endometriosis of intestine 12.1
14 endometriosis of pelvic peritoneum 12.1
15 endometriosis in scar of skin 12.1
16 endometriosis of rectovaginal septum and vagina 12.1
17 endometriosis 1 12.1
18 catamenial pneumothorax 11.6
19 pain - chronic 11.4
20 uterine anomalies 11.1
21 benign multicystic peritoneal mesothelioma 11.1
22 infertility 10.7
23 adenocarcinoma 10.5
24 pneumothorax 10.4
25 sarcoma 10.4
26 endometrial stromal sarcoma 10.4
27 clear cell adenocarcinoma 10.4
28 ovarian cancer 1 10.3
29 ovarian clear cell carcinoma 10.3
30 adenosarcoma 10.3
31 intussusception 10.3
32 mullerian aplasia 10.2 H19 WNT4
33 intestinal obstruction 10.2
34 leiomyomatosis 10.2
35 pelvic inflammatory disease 10.2
36 leiomyoma 10.2
37 ventricular fibrillation, paroxysmal familial, 1 10.2
38 hydronephrosis 10.2
39 ureteral obstruction 10.2
40 progesterone resistance 10.2
41 diffuse peritoneal leiomyomatosis 10.2
42 urinary tract obstruction 10.1
43 hypoxia 10.1
44 coronary heart disease 1 10.1 CDKN2B-AS1 H19 MIR126 MIR145
45 ovarian cyst 10.1
46 appendicitis 10.1
47 esophagus adenocarcinoma 10.1 MIR143 MIR145
48 umbilical hernia 10.1
49 ectopic pregnancy 10.1
50 carcinosarcoma 10.1

Comorbidity relations with Endometriosis via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to Endometriosis

Symptoms & Phenotypes for Endometriosis

UMLS symptoms related to Endometriosis:


pelvic pain, pain and other symptoms associated with female genital organs

Drugs & Therapeutics for Endometriosis

PubMedHealth treatment related to Endometriosis: 63

There is currently no “cure” for endometriosis – in other words, there are no treatments that can fight what is causing it. But various treatments can help relieve the symptoms, temporarily or permanently. The medication options include painkillers, hormonal contraception and stronger hormone therapy. Painkillers only relieve the symptoms, whereas hormone-based treatments slow down the growth of endometrial implants.Surgery is also an option. The aim of surgery for endometriosis is usually to remove as many endometrial implants as possible. Sometimes surgery is even necessary – for instance, if endometriosis is affecting bowel or bladder function.

Drugs for Endometriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 278)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Goserelin Approved Phase 4,Phase 3,Not Applicable 65807-02-5 47725 5311128
2
Tibolone Approved, Investigational Phase 4 5630-53-5
3
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
4
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-83-0 5994
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-28-2 5757
7
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Not Applicable 28014-46-2
8 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 979-32-8
9
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53714-56-0 657181 3911
10
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 17489-40-6, 797-63-7 13109
11
Drospirenone Approved Phase 4,Phase 3,Phase 2 67392-87-4 68873
12
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Not Applicable 57-63-6 5991
13
Sage Approved Phase 4
14
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1 120511-73-1 2187
15
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
16
Desogestrel Approved Phase 4,Not Applicable 54024-22-5 40973
17
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 6917715 40976
18
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 1 71-58-9
19
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
20
Danazol Approved Phase 4,Phase 2 17230-88-5 28417
21
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
22
Quinagolide Approved, Investigational Phase 4,Phase 2 97805-50-0, 87056-78-8 105105
23
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 360-70-3 9677
24
Nandrolone phenpropionate Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 62-90-8 229455
25
Dienogest Approved Phase 4,Phase 3,Phase 2,Not Applicable 65928-58-7
26
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
27
Norgestrel Approved Phase 4 6533-00-2 13109
28
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
29
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
30 tannic acid Approved Phase 4
31
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
32
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
33
Norepinephrine Approved Phase 4 51-41-2 439260
34
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
35
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
37
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
38 Gallopamil Investigational Phase 4 16662-47-8
39 Deslorelin Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57773-65-6
40
Enclomiphene Investigational Phase 4,Not Applicable 15690-57-0
41
Gestodene Investigational Phase 4 60282-87-3 3033968
42
Nandrolone Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 434-22-0 9904
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
46 Calciferol Phase 4
47 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
49 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
50 Vitamins Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 401)
# Name Status NCT ID Phase Drugs
1 Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis Unknown status NCT00654524 Phase 4 gonadotropin-releasing-hormone agonist (GnRHa) - Goserelin
2 Ulipristal for Endometriosis-related Pelvic Pain Unknown status NCT02213081 Phase 4 Ulipristal
3 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
4 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4 Continuous OC (clormadinone acetate plus ethinil-estradiol - Belara®, Grunenthal, Milan, Italy);Cyclic OC (clormadinone acetate plus ethinil-estradiol)
5 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
6 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4 Sanjie analgesic capsule;placebo
7 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
8 Supplementation in Adolescent Girls With Endometriosis Completed NCT02387931 Phase 4
9 Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence Completed NCT01769781 Phase 4 anastrazole;GnRH analog alone
10 Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis Completed NCT02158845 Phase 4 LNG-IUS: levonorgestrel intrauterine system;GnRHa: leuprolide
11 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed NCT01682642 Phase 4 Zoladex
12 Homeopathic Treatment of Chronic Pelvic Pain in Women With Endometriosis Completed NCT02427386 Phase 4 dynamized estrogen;placebo
13 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Completed NCT02480647 Phase 4 Levonorgestrel;Etonogestrel
14 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4 Leuprolide acetate in depot suspension;Leuprolide acetate;leuprolide acetate
15 The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis Completed NCT01581359 Phase 4 Triptorelin acetate
16 Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain Completed NCT01056042 Phase 4 intramuscular depot medroxyprogesterone acetate;ethinyl estradiol 30 micrograms, gestodene 75 micrograms
17 Resveratrol for Pain Due to Endometriosis Completed NCT02475564 Phase 4 Placebo;Resveratrol
18 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4 Danazol;placebo
19 Endometriosis Patients Undergoing Quinagolide Treatment Completed NCT00625950 Phase 4
20 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
21 Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients Completed NCT02534688 Phase 4 LNG-IUS;DMPA
22 Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women Completed NCT00735852 Phase 4 Decapeptyl SR 11.25mg
23 Understanding Experimentally Induced Hot Flushes Completed NCT00455689 Phase 4 Leuprolide acetate
24 Impact of Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
25 Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving Recruiting NCT03080558 Phase 4 Indocyanine green
26 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest Recruiting NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
27 Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery Recruiting NCT02385448 Phase 4 Dienogest;Microgynon
28 Effects of Dienogest and Dienogest Plus Estradiol Valerate in Ovarian Endometrioma Recruiting NCT03789123 Phase 4 Estradiol valerate/dienogest
29 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
30 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
31 The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation Not yet recruiting NCT03809221 Phase 4 Triptorelin acetate
32 Trans-vaginal Aspiration of Small Ovarian Endometrioma. Comparison of Two Different Techniques Before ICSI Not yet recruiting NCT03784404 Phase 4 Intracytoplasmic sperm injection
33 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4 Combined Oral Contraceptive Pill (Microgynon 30)
34 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
35 Duloxetine for the Treatment of Chronic Pelvic Pain Terminated NCT01451606 Phase 4 Duloxetine;Placebo
36 Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery Unknown status NCT01125488 Phase 3 GnRH agonist (triptorelin)
37 Subcutaneous Progesterone Supplementation in Patients With Endometriosis Unknown status NCT02793908 Phase 3 Pleyris;Crinone8
38 Laparoscopy Versus Laparotomy for Colorectal Endometriosis Unknown status NCT00939861 Phase 3
39 Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) Unknown status NCT00458458 Phase 3 Norethindrone Acetate (NA);GnRH Agonist (Lupron Depot)
40 Stimulated Versus Un-stimulated Intrauterine Insemination Cycles in Women With Endometriosis Unknown status NCT02470169 Phase 3 Merional;Choriomon
41 The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study Unknown status NCT00894946 Phase 3
42 The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol Unknown status NCT01636505 Phase 3 ghrh antagonist (cetrotide/orgalutran);gnrh agonist (suprefact)
43 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Women With Moderate to Severe Endometriosis-associated Pain Completed NCT02143713 Phase 3 Elagolix
44 Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients Completed NCT01822080 Phase 3 Dienogest (Visanne, BAY86-5258);Placebo
45 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain Completed NCT01760954 Phase 3 Elagolix
46 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01931670 Phase 3 Elagolix
47 Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis Completed NCT02271958 Phase 2, Phase 3 Mifepristone;PLACEBO
48 Degarelix in the Treatment of Endometriosis Recurrence Completed NCT01712763 Phase 3 degarelix;goserelin
49 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01620528 Phase 3 elagolix
50 Comparative Study of BAY86-5300 With an Extended Flexible Regimen for Endometriosis Completed NCT01697111 Phase 3 EE20/DRSP(BAY86-5300);Placebo;Dienogest

Search NIH Clinical Center for Endometriosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: endometriosis

Genetic Tests for Endometriosis

Genetic tests related to Endometriosis:

# Genetic test Affiliating Genes
1 Endometriosis 29

Anatomical Context for Endometriosis

MalaCards organs/tissues related to Endometriosis:

41
Uterus, Ovary, Endothelial, Testes, Colon, Monocytes, Bone

Publications for Endometriosis

Articles related to Endometriosis:

(show top 50) (show all 3861)
# Title Authors Year
1
Exosome-mediated microRNA-138 and vascular endothelial growth factor in endometriosis through inflammation and apoptosis via the nuclear factor-κB signaling pathway. ( 30431056 )
2019
2
Diverting stoma-related complications following colorectal endometriosis surgery: a 163-patient cohort. ( 30468983 )
2019
3
Abnormally located SSEA1+/SOX9+ endometrial epithelial cells with a basalis-like phenotype in the eutopic functionalis layer may play a role in the pathogenesis of endometriosis. ( 30496412 )
2019
4
Accuracy of anogenital distance and anti-Müllerian hormone in the diagnosis of endometriosis without surgery. ( 30298915 )
2019
5
Chrysin leads to cell death in endometriosis by regulation of endoplasmic reticulum stress and cytosolic calcium level. ( 30302765 )
2019
6
Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry. ( 30387804 )
2019
7
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. ( 29450941 )
2018
8
Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis. ( 29704815 )
2018
9
Endometriosis: Perspective, lights, and shadows of etiology. ( 29958140 )
2018
10
Endometriosis and adenomyosis are associated with increased risk of preterm delivery and a small-for-gestational-age child: a systematic review and meta-analysis. ( 29753309 )
2018
11
Laparoscopic surgery with urinary tract reconstruction and bowel endometriosis resection for deep infiltrating endometriosis. ( 29444547 )
2018
12
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
13
The Wnt/I^-catenin signaling in endometriosis, the expression of total and active forms of I^-catenin, total and inactive forms of glycogen synthase kinase-3I^, WNT7a and DICKKOPF-1. ( 29107840 )
2018
14
Endometriosis in the rectum accompanied by hemorrhoids leading to diagnostic pitfalls: a rare case report. ( 29973210 )
2018
15
Comparison of the efficacy of diegnogest and levonorgestrel-releasing intrauterine system after laparoscopic surgery for endometriosis. ( 29974633 )
2018
16
Current and emerging treatment options for endometriosis. ( 29975553 )
2018
17
Presumption of pericardial endometriosis using MRI: Case report and review of the literature. ( 29981475 )
2018
18
A Case of Thoracic Endometriosis Syndrome Presenting with Recurrent Catamenial Pneumothorax. ( 29769481 )
2018
19
Medical treatment in the management of deep endometriosis infiltrating the proximal rectum and sigmoid colon: a comprehensive literature review. ( 29431849 )
2018
20
Appendiceal Endometriosis and Ectopic Pregnancy Occurring Simultaneously. ( 29420399 )
2018
21
Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States. ( 29450864 )
2018
22
Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? ( 29893860 )
2018
23
Drug Development in Endometriosis and Adenomyosis: It Takes More Than Just Good Science. ( 29962279 )
2018
24
Endometriosis increased the risk of bladder pain syndrome/interstitial cystitis: A population-based study. ( 29318645 )
2018
25
Effects of pelvic endometriosis and adenomyosis on ciliary beat frequency and muscular contractions in the human fallopian tube. ( 29753325 )
2018
26
Surgical Treatment of Intestinal Endometriosis: Outcomes of Three Different Techniques. ( 29949818 )
2018
27
Current and Emerging Therapeutics for the Management of Endometriosis. ( 29946962 )
2018
28
Endometriosis does not confer improved prognosis in ovarian clear cell carcinoma: a retrospective study at a single institute. ( 29941051 )
2018
29
Endometriosis alters brain electro-physiology, gene expression and increased pain sensitization, anxiety, and depression in female mice. ( 29425272 )
2018
30
Clear Cell Adenocarcinoma Arising from Endometriosis in the Groin: Wide Resection and Reconstruction with a Fascia Lata Tensor Muscle Skin Flap. ( 29805826 )
2018
31
Abnormal activation of the sonic hedgehog signaling pathway in endometriosis and its diagnostic potency. ( 29980254 )
2018
32
Endometriosis: a rare cause of multiple lung nodules on imaging. ( 29431501 )
2018
33
Effect of neuromuscular electrical stimulation for endometriosis-associated pain: A retrospective study. ( 29953000 )
2018
34
Ileocecal endometriosis as an infrequent cause of intussusception. ( 29278003 )
2018
35
Integrating the dysregulated inflammasome-based molecular functionome in the malignant transformation of endometriosis-associated ovarian carcinoma. ( 29423077 )
2018
36
Maltreatment during childhood: a risk factor for the development of endometriosis? ( 29947745 )
2018
37
Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. ( 29428309 )
2018
38
Conducting dyadic, relational research about endometriosis: A reflexive account of methods, ethics and data analysis. ( 29978723 )
2018
39
Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis. ( 29944729 )
2018
40
Hypoxia Promotes Ectopic Adhesion Ability of Endometrial Stromal Cells via TGF-I^1/Smad Signalling in Endometriosis. ( 29438550 )
2018
41
Chemical pleurodesis with autologous blood and freeze-dried concentrated human thrombin improved spontaneous pneumothorax and thoracic endometriosis: The first case involving a pregnant woman. ( 29880183 )
2018
42
Placenta previa and placental abruption after assisted reproductive technology in patients with endometriosis: a systematic review and meta-analysis. ( 29602980 )
2018
43
Progesterone Resistance in Endometriosis: an Acquired Property? ( 29934050 )
2018
44
Relationship between methylation status of RASSF2A gene promoter and endometriosis-associated ovarian cancer. ( 29504361 )
2018
45
Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. ( 29304094 )
2018
46
Primary umbilical endometriosis. ( 29947647 )
2018
47
Endometriosis: clinical features, MR imaging findings and pathologic correlation. ( 29450853 )
2018
48
Four Case Reports of Endometriosis-Related Hemoperitoneum in Pregnancy. ( 29451162 )
2018
49
Malignant peritoneal mesothelioma in patients with endometriosis. ( 29794065 )
2018
50
A nationwide cohort study on the risk of non-gynaecological cancers in women with surgically verified endometriosis. ( 29981163 )
2018

Variations for Endometriosis

Expression for Endometriosis

LifeMap Discovery
Genes differentially expressed in tissues of Endometriosis patients vs. healthy controls: 35 (show top 50) (show all 83)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PTGIS prostaglandin I2 (prostacyclin) synthase Uterus + 5.41 0.000
2 MYH11 myosin, heavy chain 11, smooth muscle Uterus + 4.87 0.001
3 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide Uterus + 4.81 0.000
4 CNN1 calponin 1, basic, smooth muscle Uterus + 4.71 0.000
5 TAGLN transgelin Uterus + 4.63 0.000
6 PAEP progestagen-associated endometrial protein Uterus + 4.63 0.013
7 PRELP proline/arginine-rich end leucine-rich repeat protein Uterus + 4.59 0.000
8 C7 complement component 7 Uterus + 4.54 0.003
9 ACTG2 actin, gamma 2, smooth muscle, enteric Uterus + 4.48 0.003
10 TCF21 transcription factor 21 Uterus + 4.45 0.000
11 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 4.42 0.001
12 WISP2 WNT1 inducible signaling pathway protein 2 Uterus + 4.11 0.001
13 AQP1 aquaporin 1 (Colton blood group) Uterus + 4.10 0.000
14 EHF ets homologous factor Uterus - 4.10 0.000
15 FOS FBJ murine osteosarcoma viral oncogene homolog Uterus + 4.09 0.000
16 FOSB FBJ murine osteosarcoma viral oncogene homolog B Uterus + 4.07 0.000
17 SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 Uterus - 4.05 0.010
18 LMNB1 lamin B1 Uterus - 4.05 0.000
19 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.99 0.000
20 DPT dermatopontin Uterus + 3.98 0.000
21 DES desmin Uterus + 3.97 0.001
22 KCNMB1 potassium channel subfamily M regulatory beta subunit 1 Uterus + 3.96 0.001
23 GATA6 GATA binding protein 6 Uterus + 3.89 0.004
24 FZD7 frizzled class receptor 7 Uterus + 3.89 0.000
25 LEFTY2 left-right determination factor 2 Uterus + 3.88 0.001
26 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.87 0.001
27 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 3.86 0.001
28 ACKR1 atypical chemokine receptor 1 (Duffy blood group) Uterus + 3.84 0.001
29 EFHC2 EF-hand domain (C-terminal) containing 2 Uterus - 3.75 0.000
30 PDLIM3 PDZ and LIM domain 3 Uterus + 3.72 0.001
31 GPC3 glypican 3 Uterus + 3.71 0.003
32 IL20RA interleukin 20 receptor, alpha Uterus - 3.70 0.000
33 MYL9 myosin, light chain 9, regulatory Uterus + 3.70 0.001
34 VNN1 vanin 1 Uterus - 3.69 0.008
35 CTSZ cathepsin Z Uterus - 3.68 0.000
36 EHF ets homologous factor Uterus - 3.67 0.000
37 LMNB1 lamin B1 Uterus - 3.61 0.000
38 CLU clusterin Uterus + 3.58 0.002
39 ACTA2 actin, alpha 2, smooth muscle, aorta Uterus + 3.57 0.000
40 TCEAL2 transcription elongation factor A (SII)-like 2 Uterus + 3.53 0.001
41 LMOD1 leiomodin 1 (smooth muscle) Uterus + 3.52 0.003
42 LMO3 LIM domain only 3 (rhombotin-like 2) Uterus + 3.51 0.002
43 TPD52 tumor protein D52 Uterus - 3.50 0.000
44 SYNPO synaptopodin Uterus + 3.48 0.001
45 KLF2 Kruppel-like factor 2 Uterus + 3.44 0.000
46 AOC3 amine oxidase, copper containing 3 Uterus + 3.44 0.003
47 KCNK3 potassium channel, two pore domain subfamily K, member 3 Uterus + 3.44 0.007
48 ZBBX zinc finger, B-box domain containing Uterus - 3.43 0.001
49 FMO1 flavin containing monooxygenase 1 Uterus + 3.43 0.000
50 ZBBX zinc finger, B-box domain containing Uterus - 3.42 0.002
Search GEO for disease gene expression data for Endometriosis.

Pathways for Endometriosis

Pathways related to Endometriosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 MIR125A MIR126 MIR141 MIR143 MIR145 MIR150
2 10.77 MIR141 MIR200A MIR200B
3 10.11 MIR126 MIR150

GO Terms for Endometriosis

Cellular components related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 MIR125A MIR126 MIR141 MIR143 MIR150 MIR20A
2 micro-ribonucleoprotein complex GO:0035068 9.53 H19 MIR125A MIR126 MIR141 MIR143 MIR145

Biological processes related to Endometriosis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.73 MIR126 MIR143 MIR20A MIR99B
2 negative regulation of inflammatory response GO:0050728 9.71 MIR126 MIR141 MIR20A
3 negative regulation of protein kinase B signaling GO:0051898 9.69 MIR145 MIR20A MIR29C
4 positive regulation of blood vessel endothelial cell migration GO:0043536 9.67 MIR126 MIR143 MIR200A
5 negative regulation of blood vessel endothelial cell migration GO:0043537 9.63 MIR200B MIR424
6 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.63 MIR20A MIR29C MIR424
7 negative regulation of gene expression GO:0010629 9.63 CDKN2B-AS1 MIR125A MIR200B MIR20A MIR29C WNT4
8 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.62 MIR223 MIR424
9 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.62 MIR126 MIR150
10 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.61 MIR145 MIR20A
11 negative regulation of smooth muscle cell proliferation GO:0048662 9.61 MIR143 MIR145
12 positive regulation of sprouting angiogenesis GO:1903672 9.6 MIR125A MIR126
13 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.59 MIR29C MIR424
14 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.58 MIR143 MIR20A
15 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.58 MIR223 MIR424
16 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 9.57 MIR424 WNT4
17 regulation of smooth muscle contraction GO:0006940 9.56 MIR143 MIR145
18 positive regulation of endothelial cell differentiation GO:0045603 9.55 MIR150 MIR99B
19 gene silencing by miRNA GO:0035195 9.53 H19 MIR125A MIR126 MIR141 MIR143 MIR145
20 angiotensin-activated signaling pathway GO:0038166 9.52 MIR143 MIR145
21 negative regulation of vascular endothelial cell proliferation GO:1905563 9.5 MIR126 MIR29C MIR424
22 aorta smooth muscle tissue morphogenesis GO:0060414 9.48 MIR143 MIR145
23 negative regulation of angiogenesis GO:0016525 9.43 MIR125A MIR143 MIR145 MIR200B MIR29C MIR424
24 regulation of phenotypic switching GO:1900239 9.4 MIR143 MIR145
25 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.37 MIR143 MIR20A
26 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.26 MIR143 MIR145

Molecular functions related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR125A MIR126 MIR141 MIR143 MIR145 MIR150
2 RNA polymerase II complex binding GO:0000993 9.26 MIR125A MIR126 MIR145 MIR20A

Sources for Endometriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....