Aliases & Classifications for Endometriosis

MalaCards integrated aliases for Endometriosis:

Name: Endometriosis 12 76 37 29 55 43 44 15 63 73

Classifications:



External Ids:

Disease Ontology 12 DOID:289
ICD10 33 N80 N80.9
ICD9CM 35 617 617.9
MeSH 44 D004715
NCIt 50 C3014
KEGG 37 H01639
UMLS 73 C0014175

Summaries for Endometriosis

PubMed Health : 63 About endometriosis: Endometriosis is one of the most common medical conditions affecting the abdomen (lower belly) in women. In endometriosis, the kind of tissue that normally lines the inside of the womb (endometrial tissue) also grows outside of it. The medical term for endometrial tissue that has grown outside of the womb is “endometrial implants.” Some women have them without knowing it. But other women experience endometriosis as a chronic disease that causes severe pain and fertility problems. It often takes years for endometriosis to be diagnosed as the cause of these problems. Until the diagnosis is made, many women try to cope with their pain somehow. They believe that the pain – even really bad pain – is a normal part of their menstrual period.There is currently no cure for endometriosis. But there are many things that can be done to relieve the symptoms. If treatment is adapted to suit women’s personal circumstances and the severity of their endometriosis, many can cope quite well with the disease.Like with other chronic conditions, it's important to get to know your own body and how it reacts, in order to find ways to manage the symptoms. Getting hold of good information and consulting experienced, supportive doctors can help.

MalaCards based summary : Endometriosis is related to leiomyoma, uterine and ovarian epithelial cancer, and has symptoms including pelvic pain and pain and other symptoms associated with female genital organs. An important gene associated with Endometriosis is CDKN2B-AS1 (CDKN2B Antisense RNA 1
ANRIL is a recently discovered long non-coding RNA encoded in the chromosome 9p21 region. This locus is a hotspot for disease-associated polymorphisms,and it has been consistently associated with cardiovascular disease,and more recently with several cancers,diabetes,glaucoma,endometriosis among other conditions.
Dysfunction Pattern: Expression [differentially expressed]), and among its related pathways/superpathways are MicroRNAs in cancer and miRNAs involved in DNA damage response. The drugs Calcium Carbonate and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and endothelial.

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.

MedlinePlus : 43 The uterus, or womb, is the place where a baby grows when a woman is pregnant. Endometriosis is a disease in which the kind of tissue that normally grows inside the uterus grows outside the uterus. It can grow on the ovaries, fallopian tubes, bowels, or bladder. Rarely, it grows in other parts of the body. Symptoms include Pain, usually in the abdomen, lower back, or pelvic areas Infertility Heavy periods and bleeding between periods Painful menstrual cramps Some women have no symptoms at all. Having trouble getting pregnant may be the first sign. The cause of endometriosis is not known. Surgery, usually a laparoscopy, is currently the only way to be sure that you have endometriosis. Your health care provider will first take your medical history, do a pelvic exam, and maybe do imaging tests. There is no cure, but treatments help with pain and infertility. They include pain medicines, hormone treatments, and surgery. NIH: National Institute of Child Health and Human Development

Wikipedia : 76 Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the... more...

Related Diseases for Endometriosis

Diseases in the Endometriosis family:

Endometriosis 1

Diseases related to Endometriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 256)
# Related Disease Score Top Affiliating Genes
1 leiomyoma, uterine 30.0 MIR150 MIR196B MIR29C
2 ovarian epithelial cancer 29.6 H19 MIR100 MIR126
3 cervical cancer 29.2 CDKN2B-AS1 H19 MIR143 MIR196B
4 melanoma 27.6 CDKN2B-AS1 H19 MIR100 MIR141 MIR200A MIR200B
5 breast cancer 27.5 CDKN2B-AS1 H19 MIR126 MIR141 MIR143 MIR145
6 colorectal cancer 26.2 CDKN2B-AS1 H19 MIR100 MIR126 MIR141 MIR143
7 prostate cancer 26.0 CDKN2B-AS1 H19 MIR100 MIR126 MIR141 MIR143
8 ovarian cancer 26.0 CDKN2B-AS1 H19 MIR100 MIR141 MIR200A MIR200B
9 lung cancer 24.0 CDKN2B-AS1 H19 MIR100 MIR126 MIR141 MIR143
10 endometriosis of ovary 12.2
11 endometriosis of uterus 12.2
12 extrapelvic endometriosis 12.2
13 fallopian tube endometriosis 12.2
14 cervix endometriosis 12.1
15 endometriosis of intestine 12.0
16 endometriosis of pelvic peritoneum 12.0
17 endometriosis in scar of skin 12.0
18 endometriosis of rectovaginal septum and vagina 12.0
19 endometriosis 1 11.9
20 adenomyosis 11.8
21 catamenial pneumothorax 11.5
22 uterine anomalies 11.2
23 chronic pain 11.2
24 benign multicystic peritoneal mesothelioma 10.9
25 prostate disease 10.7 CDKN2B-AS1 H19
26 mullerian aplasia 10.7 H19 WNT4
27 peritonitis 10.7
28 malignant glioma 10.6 CDKN2B-AS1 H19
29 infertility 10.6
30 nonalcoholic fatty liver disease 10.5 MIR126 MIR200B MIR29C
31 endotheliitis 10.4
32 adenocarcinoma 10.4
33 coronary artery anomaly 10.3 CDKN2B-AS1 H19 MIR126 MIR145
34 thyroid cancer, nonmedullary, 1 10.3 H19 MIR200A MIR29C
35 pneumothorax 10.3
36 sarcoma 10.2
37 clear cell adenocarcinoma 10.2
38 endometrial stromal sarcoma 10.2
39 esophagus adenocarcinoma 10.2 MIR143 MIR145
40 ovarian cancer 1 10.2
41 adenosarcoma 10.2
42 vaginitis 10.1
43 leiomyoma 10.1
44 primary biliary cirrhosis 10.1 MIR150 MIR20A MIR223
45 leiomyomatosis 10.0
46 progesterone resistance 10.0
47 ovarian clear cell carcinoma 10.0
48 intussusception 10.0
49 cervicitis 10.0
50 diffuse peritoneal leiomyomatosis 10.0

Comorbidity relations with Endometriosis via Phenotypic Disease Network (PDN):


Myofibroma

Graphical network of the top 20 diseases related to Endometriosis:



Diseases related to Endometriosis

Symptoms & Phenotypes for Endometriosis

UMLS symptoms related to Endometriosis:


pelvic pain, pain and other symptoms associated with female genital organs

Drugs & Therapeutics for Endometriosis

PubMedHealth treatment related to Endometriosis: 63

There is currently no “cure” for endometriosis – in other words, there are no treatments that can fight what is causing it. But various treatments can help relieve the symptoms, temporarily or permanently. The medication options include painkillers, hormonal contraception and stronger hormone therapy. Painkillers only relieve the symptoms, whereas hormone-based treatments slow down the growth of endometrial implants.Surgery is also an option. The aim of surgery for endometriosis is usually to remove as many endometrial implants as possible. Sometimes surgery is even necessary – for instance, if endometriosis is affecting bowel or bladder function.

Drugs for Endometriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 256)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
2
Goserelin Approved Phase 4,Phase 3,Not Applicable 65807-02-5 47725 5311128
3
Tibolone Approved, Investigational Phase 4 5630-53-5
4
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-28-2 5757
6 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 979-32-8
7
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Not Applicable 28014-46-2
8
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53714-56-0 3911 657181
9
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 797-63-7, 17489-40-6 13109
10
Drospirenone Approved Phase 4,Phase 3,Phase 2 67392-87-4 68873
11
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Not Applicable 57-63-6 5991
12
Anastrozole Approved, Investigational Phase 4,Phase 2,Phase 1 120511-73-1 2187
13
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-83-0 5994
14
Ethanol Approved Phase 4,Not Applicable 64-17-5 702
15
Desogestrel Approved Phase 4,Not Applicable 54024-22-5 40973
16
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
17
Gestodene Approved, Investigational Phase 4 60282-87-3 3033968
18
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 2,Phase 1 71-58-9
19
Resveratrol Approved, Experimental, Investigational Phase 4 501-36-0 445154
20
Danazol Approved Phase 4,Phase 2 17230-88-5 28417
21
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
22
Quinagolide Approved, Investigational Phase 4 97805-50-0, 87056-78-8 105105
23
Dienogest Approved Phase 4,Phase 3,Phase 2,Not Applicable 65928-58-7
24
Nandrolone decanoate Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 360-70-3 9677
25
Nandrolone phenpropionate Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 62-90-8 229455
26
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
27
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
28
Norgestrel Approved Phase 4 6533-00-2 13109
29
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
30
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
31
Norepinephrine Approved Phase 4 51-41-2 439260
32
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
33
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
34
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
35
Sage Approved, Nutraceutical Phase 4
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 77-92-9 311
37 tannic acid Approved, Nutraceutical Phase 4,Phase 3
38 Gallopamil Investigational Phase 4 16662-47-8
39 Deslorelin Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 57773-65-6
40
Enclomiphene Investigational Phase 4,Not Applicable 15690-57-0
41
Nandrolone Experimental, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 434-22-0 9904
42 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Bone Density Conservation Agents Phase 4,Phase 2
44 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
48 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable
49 Vitamins Phase 4,Phase 2
50 Adjuvants, Immunologic Phase 4

Interventional clinical trials:

(show top 50) (show all 363)
# Name Status NCT ID Phase Drugs
1 Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis Unknown status NCT00654524 Phase 4 gonadotropin-releasing-hormone agonist (GnRHa) - Goserelin
2 Study to Compare Peritoneal Ablation by Excision Only and Excision With the Use of an Adhesion Barrier Unknown status NCT02165917 Phase 4
3 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4 Continuous OC (clormadinone acetate plus ethinil-estradiol - Belara®, Grunenthal, Milan, Italy);Cyclic OC (clormadinone acetate plus ethinil-estradiol)
4 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
5 Multi-center Clinical Trials of Sanjie Analgesic Capsule in Treating Endometriosis Unknown status NCT02031523 Phase 4 Sanjie analgesic capsule;placebo
6 Continuous Versus Cyclic Oral Contraceptives for Endometriosis Unknown status NCT02237131 Phase 4 Oral contraceptives cyclic;Oral contraceptives continuous
7 Supplementation in Adolescent Girls With Endometriosis Completed NCT02387931 Phase 4
8 Anastrazole Plus GnRH-agonist in the Treatment of Endometriosis Recurrence Completed NCT01769781 Phase 4 anastrazole;GnRH analog alone
9 Levonorgestrel-releasing Intrauterine System in Patients With Endometriosis Completed NCT02158845 Phase 4 LNG-IUS: levonorgestrel intrauterine system;GnRHa: leuprolide
10 The Influence of Adjuvant Medical Treatment of Peritoneal Endometriosis on the Outcome of IVF. A Prospective Randomized Analysis. Completed NCT01682642 Phase 4 Zoladex
11 Homeopathic Treatment of Chronic Pelvic Pain in Women With Endometriosis Completed NCT02427386 Phase 4 dynamized estrogen;placebo
12 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Completed NCT02480647 Phase 4 Levonorgestrel;Etonogestrel
13 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4 Leuprolide acetate in depot suspension;Leuprolide acetate;leuprolide acetate
14 The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis Completed NCT01581359 Phase 4 Triptorelin acetate
15 Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain Completed NCT01056042 Phase 4 intramuscular depot medroxyprogesterone acetate;ethinyl estradiol 30 micrograms, gestodene 75 micrograms
16 Resveratrol for Pain Due to Endometriosis Completed NCT02475564 Phase 4 Placebo;Resveratrol
17 Danazol Treatment in Endometriosis Women Before IVF Completed NCT01779232 Phase 4 Danazol;placebo
18 Endometriosis Patients Undergoing Quinagolide Treatment Completed NCT00625950 Phase 4
19 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
20 Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients Completed NCT02534688 Phase 4 LNG-IUS;DMPA
21 Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women Completed NCT00735852 Phase 4 Decapeptyl SR 11.25mg
22 Impact of Hot Flashes on Sleep and Mood Disturbance Completed NCT01116401 Phase 4 leuprolide
23 Estimation of Vascularization After Treatment of Deep Rectovaginal Endometriosis Node by Rectal Shaving Recruiting NCT03080558 Phase 4 Indocyanine green
24 Induction of Ovulation by Clomiphene Citrate Following Laparoscopic Surgery for Endometriosis Stage 1 and Stage 2 With and Without Suppression by Dienogest Recruiting NCT02575248 Phase 4 Dienogest 2mg;Clomiphene citrate 5 mg
25 Comparing the Use of Dienogest and Combined Oral Contraceptive Pills (Microgynon) to Reduce the Risk of Recurrence of Endometriotic Cyst After Conservative Surgery Recruiting NCT02385448 Phase 4 Dienogest;Microgynon
26 Chronic Pain Risk Associated With Menstrual Period Pain Recruiting NCT02214550 Phase 4 microgestin 1/20
27 Ulipristal for Endometriosis-related Pelvic Pain Active, not recruiting NCT02213081 Phase 4 Ulipristal
28 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
29 Pituitary Down-regulation Before IVF for Women With Endometriosis Terminated NCT01757249 Phase 4 Combined Oral Contraceptive Pill (Microgynon 30)
30 Peritoneal Cavity Conditioning Decreases Pain, Inflammation and Adhesions Terminated NCT01344486 Phase 4
31 Duloxetine for the Treatment of Chronic Pelvic Pain Terminated NCT01451606 Phase 4 Duloxetine;Placebo
32 Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery Unknown status NCT01125488 Phase 3 GnRH agonist (triptorelin)
33 Laparoscopy Versus Laparotomy for Colorectal Endometriosis Unknown status NCT00939861 Phase 3
34 Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) Unknown status NCT00458458 Phase 3 Norethindrone Acetate (NA);GnRH Agonist (Lupron Depot)
35 The In Vitro Fertilization - Lipiodol Uterine Bathing Effect Study Unknown status NCT00894946 Phase 3
36 The Results of Preimplantation Genetic Diagnosis and Preimplantation Genetic Screening of Embryos Obtained From GnRH-agonist Long and GnRH-antagonist Ovarian Stimulation Protocol Unknown status NCT01636505 Phase 3 ghrh antagonist (cetrotide/orgalutran);gnrh agonist (suprefact)
37 Understanding Experimentally Induced Hot Flushes Unknown status NCT00455689 Phase 2, Phase 3 Leuprolide acetate (Lupron)
38 Phase 3 Study of Dienogest for the Treatment of Endometriosis in Chinese Patients Completed NCT01822080 Phase 3 Dienogest (Visanne, BAY86-5258);Placebo
39 Mifepristone 2.5, 5, 10 mg Versus Placebo in the Treatment of Endometriosis Completed NCT02271958 Phase 2, Phase 3 Mifepristone;PLACEBO
40 Degarelix in the Treatment of Endometriosis Recurrence Completed NCT01712763 Phase 3 degarelix;goserelin
41 A Global Phase 3 Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01931670 Phase 3 Elagolix
42 Global Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-associated Pain Completed NCT02143713 Phase 3 Elagolix
43 A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01620528 Phase 3 Elagolix
44 Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Subjects With Moderate to Severe Endometriosis-Associated Pain Completed NCT01760954 Phase 3 Elagolix
45 Comparative Study of BAY86-5300 With an Extended Flexible Regimen for Endometriosis Completed NCT01697111 Phase 3 EE20/DRSP(BAY86-5300);Placebo;Dienogest
46 Pentoxifylline and Endometriosis Completed NCT00632697 Phase 3 pentoxifylline;placebo
47 Medical Treatment of Endometriosis-Associated Pelvic Pain Completed NCT00229996 Phase 3 Oral Contraceptive;Depot-Leuprolide/Norethindrone
48 Safety and Efficacy of SH T00660AA in Treatment of Endometriosis Completed NCT00225186 Phase 3 Visanne (SH T00660AA , BAY86-5258)
49 Efficacy and Safety of SH T00660AA in Treatment of Endometriosis Completed NCT00225199 Phase 3 Visanne (BAY86-5258, SH T00660AA);Placebo
50 The Effectiveness of Lng IUD for Treatment of the Patient Undergone Conservative Surgery for Pelvic Endometriosis Completed NCT00455845 Phase 3

Search NIH Clinical Center for Endometriosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: endometriosis

Genetic Tests for Endometriosis

Genetic tests related to Endometriosis:

# Genetic test Affiliating Genes
1 Endometriosis 29

Anatomical Context for Endometriosis

MalaCards organs/tissues related to Endometriosis:

41
Uterus, Ovary, Endothelial, Testes, Monocytes, Smooth Muscle, Colon

Publications for Endometriosis

Articles related to Endometriosis:

(show top 50) (show all 2787)
# Title Authors Year
1
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. ( 29450941 )
2018
2
Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis. ( 29704815 )
2018
3
Endometriosis: Perspective, lights, and shadows of etiology. ( 29958140 )
2018
4
Endometriosis and adenomyosis are associated with increased risk of preterm delivery and a small-for-gestational-age child: a systematic review and meta-analysis. ( 29753309 )
2018
5
Laparoscopic surgery with urinary tract reconstruction and bowel endometriosis resection for deep infiltrating endometriosis. ( 29444547 )
2018
6
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
7
The Wnt/I^-catenin signaling in endometriosis, the expression of total and active forms of I^-catenin, total and inactive forms of glycogen synthase kinase-3I^, WNT7a and DICKKOPF-1. ( 29107840 )
2018
8
Endometriosis in the rectum accompanied by hemorrhoids leading to diagnostic pitfalls: a rare case report. ( 29973210 )
2018
9
Comparison of the efficacy of diegnogest and levonorgestrel-releasing intrauterine system after laparoscopic surgery for endometriosis. ( 29974633 )
2018
10
Current and emerging treatment options for endometriosis. ( 29975553 )
2018
11
Presumption of pericardial endometriosis using MRI: Case report and review of the literature. ( 29981475 )
2018
12
A Case of Thoracic Endometriosis Syndrome Presenting with Recurrent Catamenial Pneumothorax. ( 29769481 )
2018
13
Medical treatment in the management of deep endometriosis infiltrating the proximal rectum and sigmoid colon: a comprehensive literature review. ( 29431849 )
2018
14
Appendiceal Endometriosis and Ectopic Pregnancy Occurring Simultaneously. ( 29420399 )
2018
15
Real-World Evaluation of Direct and Indirect Economic Burden Among Endometriosis Patients in the United States. ( 29450864 )
2018
16
Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? ( 29893860 )
2018
17
Drug Development in Endometriosis and Adenomyosis: It Takes More Than Just Good Science. ( 29962279 )
2018
18
Endometriosis increased the risk of bladder pain syndrome/interstitial cystitis: A population-based study. ( 29318645 )
2018
19
Effects of pelvic endometriosis and adenomyosis on ciliary beat frequency and muscular contractions in the human fallopian tube. ( 29753325 )
2018
20
Surgical Treatment of Intestinal Endometriosis: Outcomes of Three Different Techniques. ( 29949818 )
2018
21
Current and Emerging Therapeutics for the Management of Endometriosis. ( 29946962 )
2018
22
Endometriosis does not confer improved prognosis in ovarian clear cell carcinoma: a retrospective study at a single institute. ( 29941051 )
2018
23
Endometriosis alters brain electro-physiology, gene expression and increased pain sensitization, anxiety, and depression in female mice. ( 29425272 )
2018
24
Clear Cell Adenocarcinoma Arising from Endometriosis in the Groin: Wide Resection and Reconstruction with a Fascia Lata Tensor Muscle Skin Flap. ( 29805826 )
2018
25
Abnormal activation of the sonic hedgehog signaling pathway in endometriosis and its diagnostic potency. ( 29980254 )
2018
26
Endometriosis: a rare cause of multiple lung nodules on imaging. ( 29431501 )
2018
27
Effect of neuromuscular electrical stimulation for endometriosis-associated pain: A retrospective study. ( 29953000 )
2018
28
Ileocecal endometriosis as an infrequent cause of intussusception. ( 29278003 )
2018
29
Integrating the dysregulated inflammasome-based molecular functionome in the malignant transformation of endometriosis-associated ovarian carcinoma. ( 29423077 )
2018
30
Maltreatment during childhood: a risk factor for the development of endometriosis? ( 29947745 )
2018
31
Mycoplasma genitalium can modulate the local immune response in patients with endometriosis. ( 29428309 )
2018
32
Conducting dyadic, relational research about endometriosis: A reflexive account of methods, ethics and data analysis. ( 29978723 )
2018
33
Systematic review and meta-analysis of complementary treatments for women with symptomatic endometriosis. ( 29944729 )
2018
34
Hypoxia Promotes Ectopic Adhesion Ability of Endometrial Stromal Cells via TGF-I^1/Smad Signalling in Endometriosis. ( 29438550 )
2018
35
Chemical pleurodesis with autologous blood and freeze-dried concentrated human thrombin improved spontaneous pneumothorax and thoracic endometriosis: The first case involving a pregnant woman. ( 29880183 )
2018
36
Placenta previa and placental abruption after assisted reproductive technology in patients with endometriosis: a systematic review and meta-analysis. ( 29602980 )
2018
37
Progesterone Resistance in Endometriosis: an Acquired Property? ( 29934050 )
2018
38
Relationship between methylation status of RASSF2A gene promoter and endometriosis-associated ovarian cancer. ( 29504361 )
2018
39
Positive associations between upregulated levels of stress-induced phosphoprotein 1 and matrix metalloproteinase-9 in endometriosis/adenomyosis. ( 29304094 )
2018
40
Primary umbilical endometriosis. ( 29947647 )
2018
41
Endometriosis: clinical features, MR imaging findings and pathologic correlation. ( 29450853 )
2018
42
Four Case Reports of Endometriosis-Related Hemoperitoneum in Pregnancy. ( 29451162 )
2018
43
Malignant peritoneal mesothelioma in patients with endometriosis. ( 29794065 )
2018
44
A nationwide cohort study on the risk of non-gynaecological cancers in women with surgically verified endometriosis. ( 29981163 )
2018
45
Circulating Neutrophil Extracellular Traps Are Elevated in Patients With Deep Infiltrating Endometriosis. ( 29448896 )
2018
46
Is the presence of endometriosis associated with a survival benefit in pure ovarian clear cell carcinoma? ( 29383437 )
2018
47
Ileocecal intussusception extending to left colon due to endometriosis. ( 29364012 )
2018
48
Associations between a single nucleotide polymorphism of stress-induced phosphoprotein 1 and endometriosis/adenomyosis. ( 29673672 )
2018
49
Effect of Mst1 on Endometriosis Apoptosis and Migration: Role of Drp1-Related Mitochondrial Fission and Parkin-Required Mitophagy. ( 29448246 )
2018
50
Endometriosis does not affect live birth rates of patients submitted to assisted reproduction techniques: analysis of the Latin American Network Registry database from 1995 to 2011. ( 29946760 )
2018

Variations for Endometriosis

Expression for Endometriosis

LifeMap Discovery
Genes differentially expressed in tissues of Endometriosis patients vs. healthy controls: 35 (show top 50) (show all 83)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 PTGIS prostaglandin I2 (prostacyclin) synthase Uterus + 5.41 0.000
2 MYH11 myosin, heavy chain 11, smooth muscle Uterus + 4.87 0.001
3 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide Uterus + 4.81 0.000
4 CNN1 calponin 1, basic, smooth muscle Uterus + 4.71 0.000
5 TAGLN transgelin Uterus + 4.63 0.000
6 PAEP progestagen-associated endometrial protein Uterus + 4.63 0.013
7 PRELP proline/arginine-rich end leucine-rich repeat protein Uterus + 4.59 0.000
8 C7 complement component 7 Uterus + 4.54 0.003
9 ACTG2 actin, gamma 2, smooth muscle, enteric Uterus + 4.48 0.003
10 TCF21 transcription factor 21 Uterus + 4.45 0.000
11 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 4.42 0.001
12 WISP2 WNT1 inducible signaling pathway protein 2 Uterus + 4.11 0.001
13 AQP1 aquaporin 1 (Colton blood group) Uterus + 4.10 0.000
14 EHF ets homologous factor Uterus - 4.10 0.000
15 FOS FBJ murine osteosarcoma viral oncogene homolog Uterus + 4.09 0.000
16 FOSB FBJ murine osteosarcoma viral oncogene homolog B Uterus + 4.07 0.000
17 SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1 Uterus - 4.05 0.010
18 LMNB1 lamin B1 Uterus - 4.05 0.000
19 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.99 0.000
20 DPT dermatopontin Uterus + 3.98 0.000
21 DES desmin Uterus + 3.97 0.001
22 KCNMB1 potassium channel subfamily M regulatory beta subunit 1 Uterus + 3.96 0.001
23 GATA6 GATA binding protein 6 Uterus + 3.89 0.004
24 FZD7 frizzled class receptor 7 Uterus + 3.89 0.000
25 LEFTY2 left-right determination factor 2 Uterus + 3.88 0.001
26 SLC26A4 solute carrier family 26 (anion exchanger), member 4 Uterus - 3.87 0.001
27 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) Uterus - 3.86 0.001
28 ACKR1 atypical chemokine receptor 1 (Duffy blood group) Uterus + 3.84 0.001
29 EFHC2 EF-hand domain (C-terminal) containing 2 Uterus - 3.75 0.000
30 PDLIM3 PDZ and LIM domain 3 Uterus + 3.72 0.001
31 GPC3 glypican 3 Uterus + 3.71 0.003
32 IL20RA interleukin 20 receptor, alpha Uterus - 3.70 0.000
33 MYL9 myosin, light chain 9, regulatory Uterus + 3.70 0.001
34 VNN1 vanin 1 Uterus - 3.69 0.008
35 CTSZ cathepsin Z Uterus - 3.68 0.000
36 EHF ets homologous factor Uterus - 3.67 0.000
37 LMNB1 lamin B1 Uterus - 3.61 0.000
38 CLU clusterin Uterus + 3.58 0.002
39 ACTA2 actin, alpha 2, smooth muscle, aorta Uterus + 3.57 0.000
40 TCEAL2 transcription elongation factor A (SII)-like 2 Uterus + 3.53 0.001
41 LMOD1 leiomodin 1 (smooth muscle) Uterus + 3.52 0.003
42 LMO3 LIM domain only 3 (rhombotin-like 2) Uterus + 3.51 0.002
43 TPD52 tumor protein D52 Uterus - 3.50 0.000
44 SYNPO synaptopodin Uterus + 3.48 0.001
45 KLF2 Kruppel-like factor 2 Uterus + 3.44 0.000
46 AOC3 amine oxidase, copper containing 3 Uterus + 3.44 0.003
47 KCNK3 potassium channel, two pore domain subfamily K, member 3 Uterus + 3.44 0.007
48 ZBBX zinc finger, B-box domain containing Uterus - 3.43 0.001
49 FMO1 flavin containing monooxygenase 1 Uterus + 3.43 0.000
50 ZBBX zinc finger, B-box domain containing Uterus - 3.42 0.002
Search GEO for disease gene expression data for Endometriosis.

Pathways for Endometriosis

GO Terms for Endometriosis

Cellular components related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 MIR100 MIR126 MIR141 MIR143 MIR150 MIR20A

Biological processes related to Endometriosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.81 MIR200B MIR20A MIR29C WNT4
2 positive regulation of angiogenesis GO:0045766 9.76 MIR126 MIR143 MIR20A
3 negative regulation of protein kinase B signaling GO:0051898 9.65 MIR145 MIR29C MIR34C
4 positive regulation of blood vessel endothelial cell migration GO:0043536 9.63 MIR126 MIR143 MIR200A
5 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.62 MIR126 MIR150
6 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.61 MIR145 MIR20A
7 negative regulation of sprouting angiogenesis GO:1903671 9.61 MIR20A MIR34C
8 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.6 MIR223 MIR424
9 negative regulation of smooth muscle cell proliferation GO:0048662 9.59 MIR143 MIR145
10 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.58 MIR29C MIR424
11 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.58 MIR20A MIR29C MIR424
12 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.57 MIR143 MIR20A
13 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 9.56 MIR424 WNT4
14 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.55 MIR223 MIR424
15 regulation of smooth muscle contraction GO:0006940 9.54 MIR143 MIR145
16 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.52 MIR20A MIR34C
17 angiotensin-activated signaling pathway GO:0038166 9.49 MIR143 MIR145
18 aorta smooth muscle tissue morphogenesis GO:0060414 9.43 MIR143 MIR145
19 negative regulation of vascular endothelial cell proliferation GO:1905563 9.43 MIR126 MIR29C MIR424
20 gene silencing by miRNA GO:0035195 9.4 MIR126 MIR141 MIR143 MIR145 MIR150 MIR200A
21 regulation of phenotypic switching GO:1900239 9.37 MIR143 MIR145
22 negative regulation of angiogenesis GO:0016525 9.35 MIR143 MIR145 MIR200B MIR29C MIR424
23 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.32 MIR143 MIR20A
24 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.16 MIR143 MIR145

Molecular functions related to Endometriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.36 MIR126 MIR141 MIR143 MIR145 MIR150 MIR200A
2 RNA polymerase II core binding GO:0000993 9.13 MIR126 MIR145 MIR20A

Sources for Endometriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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