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MCID: END011
MIFTS: 39

Endometriosis of Ovary

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endometriosis of Ovary

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MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 71 32
Ovarian Endometriosis 12 17

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11432
ICD9CM 34 617.1
NCIt 49 C27628
SNOMED-CT 67 266589005
ICD10 32 N80.1
UMLS 71 C0156344
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Summaries for Endometriosis of Ovary

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Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and ovarian cyst. An important gene associated with Endometriosis of Ovary is MIR141 (MicroRNA 141), and among its related pathways/superpathways are MicroRNAs in cancer and MNAR-PELP1 and Estrogen Receptor Interaction. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial.

Wikipedia : 74 Endometrioma is the presence of endometrial tissue in and sometimes on the ovary. It is the most common... more...

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Related Diseases for Endometriosis of Ovary

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Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 endometriosis 31.1 MIR145 MIR141 GNRH1 ESR2 ESR1 CYP19A1
2 ovarian cyst 30.4 MIR145 GNRH1 ESR2 CYP19A1 AMH
3 progesterone resistance 30.4 HSD17B2 ESR2 ESR1
4 adenomyosis 30.2 GNRH1 ESR2 ESR1 CYP19A1
5 leiomyoma 30.2 GNRH1 ESR2 ESR1 CYP19A1
6 ovarian serous cystadenocarcinoma 30.1 ESR2 ESR1 ARID1A
7 myoma 30.0 GNRH1 ESR1 CYP19A1 AMH
8 leiomyoma, uterine 30.0 GNRH1 ESR2 ESR1 CYP19A1
9 adenomyoma 29.9 GNRH1 ESR1
10 endometrial hyperplasia 29.8 ESR2 ESR1 CYP19A1 ARID1A
11 estrogen excess 29.5 GNRH1 ESR2 ESR1 CYP19A1
12 endometrial cancer 29.4 MIR145 MIR141 GNRH1 ESR2 ESR1 CYP19A1
13 male infertility 29.4 GNRH1 ESR2 ESR1 CYP19A1
14 ovarian disease 28.9 MIR9-1 MIR145 MIR141 GNRH1 ESR2 ESR1
15 extrapelvic endometriosis 10.4
16 ovarian cancer 10.4
17 infertility 10.4
18 subserous uterine fibroid 10.4 CYP19A1 AMH
19 nonmucinous bronchioloalveolar adenocarcinoma 10.4 ESR2 ESR1
20 bile duct adenocarcinoma 10.4 MIR9-1 MIR30E MIR145
21 bile duct cystadenoma 10.3 ESR2 ESR1
22 bile duct disease 10.3 MIR9-1 MIR30E MIR145
23 pharynx cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
24 biliary tract disease 10.3 MIR9-1 MIR30E MIR145
25 arteries, anomalies of 10.3 MIR9-1 MIR30E MIR145 MIR141
26 lymphatic system cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
27 mammographic density 10.3 ESR1 CYP19A1
28 lymphatic system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
29 pancreas disease 10.3 MIR9-1 MIR30E MIR145 MIR141
30 bone marrow cancer 10.3 MIR9-1 MIR30E MIR145
31 endocrine system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
32 urinary system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
33 male reproductive organ cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
34 immune system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
35 male reproductive system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
36 infertility due to extratesticular cause 10.3 GNRH1 ESR1
37 reproductive system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
38 large intestine cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
39 endocrine gland cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
40 respiratory system cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
41 ovarian clear cell carcinoma 10.3
42 female reproductive system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
43 vaginal adenoma 10.3 ESR2 CYP19A1
44 vaginal benign neoplasm 10.3 ESR2 CYP19A1
45 respiratory system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
46 gastrointestinal system cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
47 transsexualism 10.2 ESR2 CYP19A1
48 gastrointestinal system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
49 ovarian epithelial cancer 10.2
50 nasopharyngeal disease 10.2 MIR9-1 MIR30E MIR141

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Fallopian Tube Endometriosis Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary
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Symptoms & Phenotypes for Endometriosis of Ovary

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Drugs & Therapeutics for Endometriosis of Ovary

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Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 5311128 47725
3 Antineoplastic Agents, Hormonal Phase 4
4 Estrogen Antagonists Phase 4
5 Aromatase Inhibitors Phase 4
6 Estrogens Phase 4
7 Estrogen Receptor Antagonists Phase 4
8
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
9
Medroxyprogesterone Phase 2 520-85-4 10631
10 Hormones
11 Hormone Antagonists
12 Hemostatics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 A Phase IIa Efficacy and Safety Study of PGL5001 Versus Placebo Administered for up to 5 Months With Concomitant Administration of Depot Medroxyprogesterone Acetate for the Treatment of Peritoneal and/or Ovarian Endometriosis With an Inflammatory Component. Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 Optimum Menstrual Cycle Time for Endometrioma Excision Unknown status NCT03484546
4 "Identification, Characterization and Isolation of Somatic Stem Cells in Human Endometrium of Women With Endometriosis" Unknown status NCT01412138
5 Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy Completed NCT03826355
6 Methylation of cfDNA in Diagnosis and Differential Diagnosis of Ovarian Endometriosis Recruiting NCT04220710
7 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma: A Randomized Control Trial Recruiting NCT03430609
8 Perinatal Consequences of Endometriosis: Multicenter Prospective Comparative Study Active, not recruiting NCT02498691
9 Study of the Relationship Between Oxidative Stress Gene Polymorphism and Individual Variation of Ovarian Reserve Function in Patients With Ovarian Endometrioma Not yet recruiting NCT03682341

Search NIH Clinical Center for Endometriosis of Ovary

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Genetic Tests for Endometriosis of Ovary

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Anatomical Context for Endometriosis of Ovary

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The Foundational Model of Anatomy Ontology organs/tissues related to Endometriosis of Ovary:

19
Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

40
Ovary, Uterus, Endothelial, Colon, T Cells, Liver, Breast
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Publications for Endometriosis of Ovary

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Articles related to Endometriosis of Ovary:

(show top 50) (show all 799)
# Title Authors PMID Year
1
Ezrin T567 phosphorylation regulates migration and invasion of ectopic endometrial stromal cells by changing actin cytoskeleton. 61
32380081 2020
2
The role of miR-34c-5p/Notch in epithelial-mesenchymal transition (EMT) in endometriosis. 61
32353411 2020
3
Robotic glove port technique for the endowristed rigid instruments in robotic single-site transabdominal and transvaginal surgery. 61
32506299 2020
4
The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages. 61
32172005 2020
5
MRI image features and differential diagnoses of Herlyn-Werner-Wunderlich syndrome. 61
31657238 2020
6
Adenomyosis and endometriosis in adolescents and young women with pelvic pain: prevalence and risk factors. 61
32549030 2020
7
Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts. 61
32564961 2020
8
YAP1 inhibits ovarian endometriosis stromal cell invasion through ESR2. 61
32544876 2020
9
Oocyte cryopreservation for fertility preservation in women with ovarian endometriosis. 61
32295746 2020
10
Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review. 61
32385745 2020
11
Cancers associated with extraovarian endometriosis at less common/rare sites: A nationwide survey in Japan. 61
32212420 2020
12
A novel non-invasive molecular biomarker in ovarian endometriosis: estrogen-related receptor α. 61
32468161 2020
13
Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature. 61
32452019 2020
14
Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis. 61
32473611 2020
15
Fertility Outcomes After Laparoscopic Cystectomy in Infertile Patients with Stage III-IV Endometriosis: a Cohort with 6-10 years of Follow-up. 61
32200536 2020
16
Pathology of clear cell carcinoma of the ovary: A basic view based on cultured cells and modern view from comprehensive approaches. 61
32476214 2020
17
A new approach to avoid ovarian failure as well function-impairing adhesion formation in endometrioma infertility surgery. 61
32206876 2020
18
IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis. 61
32436195 2020
19
Recurrence Rate after "One-Step" CO2 Fiber Laser Vaporization versus Cystectomy for Ovarian Endometrioma: A 3-Year Follow-up Study. 61
31377455 2020
20
Malignant risk of pelvic mass after hysterectomy for adenomyosis or endometriosis. 61
32282727 2020
21
Usefulness of subtraction pelvic magnetic resonance imaging for detection of ovarian endometriosis. 61
31661751 2020
22
Novel MYH8 mutations in 152 Han Chinese samples with ovarian endometriosis. 61
32308057 2020
23
The miR-25-3p/Sp1 pathway is dysregulated in ovarian endometriosis. 61
32299271 2020
24
Impacts of medroxyprogesterone acetate on oocytes and embryos: matched case-control study in women with stage III-IV ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization. 61
32355821 2020
25
The differential ultrasonic diagnosis of ovarian endometriosis and ovarian cancer. 61
32192323 2020
26
Somatically Derived Yolk Sac Tumor of the Ovary in a Young Woman. 61
32209818 2020
27
Ultrasound findings in infertile women with endometriosis: evidence of concomitant uterine disorders. 61
32133885 2020
28
Comparative immunohistochemical study of deep infiltrating endometriosis, lymph node endometriosis and atypical ovarian endometriosis including description of a perineural invasion. 61
32158015 2020
29
Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer. 61
31736153 2020
30
Comparative analysis of abdominal fluid cytokine levels in ovarian hyperstimulation syndrome (OHSS). 61
32138790 2020
31
Endometrioma, the follicular fluid inflammatory network and its association with oocyte and embryo characteristics. 61
32057676 2020
32
The role of survivin in the pathogenesis of endometriosis. 61
31755675 2020
33
Live birth rate comparison of three controlled ovarian stimulation protocols for in vitro fertilization-embryo transfer in patients with diminished ovarian reserve after endometrioma cystectomy: a retrospective study. 61
32113477 2020
34
Expression profiles of tRNA-derived fragments and their potential roles in ovarian endometriosis. 61
31845823 2020
35
The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model. 61
31889882 2020
36
Painful Love: Superficial Dyspareunia and Three Dimensional Transperineal Ultrasound Evaluation of Pelvic Floor Muscle in Women with Endometriosis. 61
31612796 2020
37
Endometriosis and risk of ovarian cancer: what do we know? 61
31745637 2020
38
Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis. 61
31610174 2020
39
Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition. 61
32400148 2020
40
Is dienogest the best medical treatment for ovarian endometriomas? Results of a multicentric case control study. 61
31311360 2020
41
Ginsenoside Rg3 attenuates endometriosis by inhibiting the viability of human ectopic endometrial stromal cells through the nuclear factor-kappaB signaling pathway. 61
31563698 2020
42
Estimation to efficiency of the multifunction method оf endometriosis ovariеs treatment. 61
32386360 2020
43
Common and specific gene signatures among three different endometriosis subtypes. 61
32185115 2020
44
Right postoperative pleural effusion and pulmonary embolism following laparoscopic gynecological surgery: A rare case report and PRISMA-driven systematic review. 61
31135576 2019
45
An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis. 61
31878927 2019
46
Unusual uptake of 131iodine in bilateral ovarian endometriosis cysts in a patient with thyroid cancer. 61
31502210 2019
47
Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? 61
31888633 2019
48
E2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis. 61
31560827 2019
49
Factors associated with ovarian endometriosis malignancy and its recurrence in Chinese women. 61
31307261 2019
50
Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis. 61
31551156 2019
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Variations for Endometriosis of Ovary

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Expression for Endometriosis of Ovary

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Search GEO for disease gene expression data for Endometriosis of Ovary.
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Pathways for Endometriosis of Ovary

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Pathways related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 36
11.75 MIR9-1 MIR30E MIR145 MIR141
2
MNAR-PELP1 and Estrogen Receptor Interaction 63
10.52 ESR2 ESR1
3
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 60
9.4 ESR2 ESR1 CYP19A1
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GO Terms for Endometriosis of Ovary

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Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 uterus development GO:0060065 9.26 ESR1 CYP19A1
2 androgen metabolic process GO:0008209 9.16 ESR1 CYP19A1
3 estrogen biosynthetic process GO:0006703 8.96 HSD17B2 CYP19A1
4 intracellular estrogen receptor signaling pathway GO:0030520 8.8 ESR2 ESR1 ARID1A

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.46 MIR9-1 MIR30E MIR145 MIR141
2 estrogen receptor activity GO:0030284 8.96 ESR2 ESR1
3 estrogen response element binding GO:0034056 8.62 ESR2 ESR1
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Sources for Endometriosis of Ovary

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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