MCID: END011
MIFTS: 36

Endometriosis of Ovary

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Endometriosis of Ovary

MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 74
Ovarian Endometriosis 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:11432
ICD9CM 36 617.1
NCIt 51 C27628
SNOMED-CT 69 31007005
ICD10 34 N80.1
UMLS 74 C0156344

Summaries for Endometriosis of Ovary

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to ovarian clear cell carcinoma and ovarian cancer 1. An important gene associated with Endometriosis of Ovary is ESR2 (Estrogen Receptor 2). The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial.

Wikipedia : 77 Endometrioma is the presence of endometrial tissue in and sometimes on the ovary. It is the most common... more...

Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell carcinoma 30.3 ARID1A HNF1B
2 ovarian cancer 1 30.3 ARID1A HNF1B
3 ovary adenocarcinoma 30.1 ARID1A HNF1B
4 endometriosis 11.0
5 extrapelvic endometriosis 10.3
6 clear cell adenocarcinoma 10.3 ARID1A HNF1B
7 ovarian cancer 10.2
8 sarcoma 10.2
9 adenocarcinoma 10.2
10 malignant ovarian surface epithelial-stromal neoplasm 10.2 ARID1A HNF1B
11 ovarian clear cell adenocarcinoma 10.1 ARID1A ESR2 HNF1B
12 ovary epithelial cancer 10.1 ARID1A HNF1B
13 squamous cell carcinoma 10.1
14 infertility 10.1
15 hydatidiform mole, recurrent, 1 10.0
16 adenomyosis 10.0
17 joint disorders 10.0
18 ectopic pregnancy 10.0
19 ulceration of vulva 10.0
20 leiomyoma 10.0
21 acromegaly 10.0
22 gestational trophoblastic neoplasm 10.0
23 arthropathy 10.0
24 adenoma 10.0
25 ovarian epithelial cancer 10.0
26 female reproductive system disease 10.0 ARID1A ESR2
27 leiomyoma, uterine 9.8
28 persistent mullerian duct syndrome 9.8
29 pelvic inflammatory disease 9.8
30 ovarian disease 9.8
31 adenofibroma 9.8
32 endometrial adenocarcinoma 9.8
33 cystadenocarcinoma 9.8
34 serous cystadenocarcinoma 9.8
35 teratoma 9.8
36 endometrial stromal sarcoma 9.8
37 spindle cell sarcoma 9.8
38 carcinosarcoma 9.8
39 leiomyomatosis 9.8
40 intestinal disease 9.8
41 clear cell adenofibroma 9.8
42 ovarian germ cell teratoma 9.8
43 diffuse peritoneal leiomyomatosis 9.8
44 intravenous leiomyomatosis 9.8
45 salpingitis 9.8
46 ovarian serous cystadenocarcinoma 9.8
47 in situ carcinoma 9.8

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Fallopian Tube Endometriosis Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary

Symptoms & Phenotypes for Endometriosis of Ovary

Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 5311128 47725
3 Hormones Phase 4,Not Applicable
4 Hormone Antagonists Phase 4,Not Applicable
5 Antineoplastic Agents, Hormonal Phase 4,Phase 2
6 Estrogen Receptor Antagonists Phase 4
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
8 Steroid Synthesis Inhibitors Phase 4
9 Estrogen Antagonists Phase 4
10 Estrogens Phase 4
11 Aromatase Inhibitors Phase 4
12
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
13
Axitinib Approved, Investigational Phase 1, Phase 2 319460-85-0 6450551
14
afatinib Approved Phase 1, Phase 2 850140-72-6, 439081-18-2 10184653
15 Contraceptive Agents, Male Phase 2
16 Contraceptive Agents Phase 2
17
Medroxyprogesterone Phase 2 520-85-4 10631
18 Protein Kinase Inhibitors Phase 1, Phase 2
19
Pentetic acid Approved Not Applicable 67-43-6
20
Edetic Acid Approved, Vet_approved Not Applicable 60-00-4, 62-33-9 6049
21 Anesthetics Not Applicable
22 Follicle Stimulating Hormone Not Applicable
23 Hemostatics Not Applicable
24 Coagulants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 PGL5001 Proof of Concept Study in Inflammatory Endometriosis Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis Not yet recruiting NCT03481842 Phase 1, Phase 2 BIBW2992;Axitinib
4 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
5 Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy Completed NCT03826355 Not Applicable
6 Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients Completed NCT02984774 Not Applicable
7 Artificial Reproductive Techniques (ART) and Progression of Endometriosis Symptoms Completed NCT02762461
8 Perinatal Consequences of Endometriosis Active, not recruiting NCT02498691 Not Applicable
9 Oxidative Stress Gene Polymorphism and Ovarian Reserve Functione Not yet recruiting NCT03682341
10 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma Not yet recruiting NCT03430609 Not Applicable

Search NIH Clinical Center for Endometriosis of Ovary

Genetic Tests for Endometriosis of Ovary

Anatomical Context for Endometriosis of Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

42
Ovary, Uterus, Endothelial, Liver, Cervix, Smooth Muscle, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Endometriosis of Ovary:

20
The Ovary

Publications for Endometriosis of Ovary

Articles related to Endometriosis of Ovary:

(show top 50) (show all 258)
# Title Authors Year
1
Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis. ( 30882467 )
2019
2
Mitochondria and oxidative stress in ovarian endometriosis. ( 30926565 )
2019
3
Aberrant expression of CHL1 gene and long non-coding RNA CHL1-AS1, CHL1-AS2 in ovarian endometriosis. ( 30943448 )
2019
4
Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions. ( 30943930 )
2019
5
Extra-uterine low grade endometrioid stromal sarcoma arising from ovarian endometriosis: a case report and review of the literature. ( 30723546 )
2019
6
Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization. ( 29806498 )
2019
7
Vibrational characterization of granulosa cells from patients affected by unilateral ovarian endometriosis: New insights from infrared and Raman microspectroscopy. ( 30639914 )
2019
8
Mutation analysis of ZP1, ZP2, ZP3 and ZP4 genes in 152 Han Chinese samples with ovarian endometriosis. ( 30611916 )
2019
9
Aberrant methylation of the IL-12B promotor region contributes to the risk of developing ovarian endometriosis. ( 30865360 )
2019
10
Leyomiomatosis peritonealis disseminata associated with ovarian endometriosis in a patient submitted to hysteroscopic myomectomy. ( 31030890 )
2019
11
Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis-associated tumorigenesis. ( 31022415 )
2019
12
Downregulation of lncrna uca1 as a diagnostic and prognostic biomarker for ovarian endometriosis. ( 30994830 )
2019
13
Hypomethylation of the GSTM1 promoter is associated with ovarian endometriosis. ( 30989213 )
2019
14
Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis. ( 29928437 )
2018
15
Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. ( 29483390 )
2018
16
The Relationship of Circular RNAs With Ovarian Endometriosis. ( 29490568 )
2018
17
Factors that Differentiate between Endometriosis-associated Ovarian Cancer and Benign Ovarian Endometriosis with Mural Nodules. ( 28824051 )
2018
18
Pelvic floor muscle assessment on three- and four-dimensional transperineal ultrasound in women with ovarian endometriosis with or without retroperitoneal infiltration: a step towards complete functional assessment. ( 29024196 )
2018
19
Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma. ( 28930811 )
2018
20
Integration analysis of microRNA and mRNA paired expression profiling identifies deregulated microRNA-transcription factor-gene regulatory networks in ovarian endometriosis. ( 29357938 )
2018
21
Circular RNA expression in ovarian endometriosis. ( 29334789 )
2018
22
Immunohistochemical Features of O6-Methylguanine-DNA Methyltransferase Expression during Ovarian Endometriosis. ( 29308563 )
2018
23
EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression. ( 29558202 )
2018
24
Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated? ( 29551389 )
2018
25
The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis. ( 29547736 )
2018
26
Novel TRERF1 mutations in Chinese patients with ovarian endometriosis. ( 29393434 )
2018
27
A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis. ( 29738836 )
2018
28
Ovarian endometriosis: risk factor analysis and prediction of malignant transformation. ( 29725285 )
2018
29
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis. ( 29669342 )
2018
30
Decreased Expression of HOXA10 May Activate the Autophagic Process in Ovarian Endometriosis. ( 29658437 )
2018
31
Ovarian endometriosis and fertility preservation: a challenge in 2018. ( 29644329 )
2018
32
Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis. ( 29920364 )
2018
33
Comparison of Outcomes of Different Postoperative Hormone Therapy in the Treatment of Ovarian Endometriosis: A Brief Report. ( 29873006 )
2018
34
Novel CTCF mutations in Chinese patients with ovarian endometriosis. ( 29845264 )
2018
35
G protein‑coupled estrogen receptor/miR‑148a/human leukocyte antigen‑G signaling pathway mediates cell apoptosis of ovarian endometriosis. ( 29845209 )
2018
36
Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over. ( 29786043 )
2018
37
Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis. ( 29763921 )
2018
38
Ovarian endometriosis and infertility: in vitro fertilization (IVF) or surgery as the first approach? ( 30503109 )
2018
39
Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics. ( 30566420 )
2018
40
Endometrioid adenocarcinoma originating simultaneously from endometrium, sites of adenomyosis and ovarian endometriosis: A case report and review of our cancer database. ( 29096350 )
2017
41
A case of spontaneous abortion related to ovarian endometriosis in a Golden Retriever dog. ( 28588636 )
2017
42
Aberrant Methylation of the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endometriosis. ( 27023436 )
2017
43
Ovarian endometriosis during pregnancy: a series of 53 endometriomas. ( 26482730 )
2017
44
Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population. ( 27233752 )
2017
45
Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis. ( 27646154 )
2017
46
Ovarian endometriosis and vitamin D serum levels. ( 27809683 )
2017
47
Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis. ( 27694140 )
2017
48
Ten Principles for Safe Surgical Treatment of Ovarian Endometriosis. ( 27932268 )
2017
49
Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis. ( 27928852 )
2017
50
Diagnostic performance of human epididymis protein 4 compared to a combination of biophysical and biochemical markers to differentiate ovarian endometriosis from epithelial ovarian cancer in premenopausal women. ( 29027715 )
2017

Variations for Endometriosis of Ovary

Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

Pathways for Endometriosis of Ovary

GO Terms for Endometriosis of Ovary

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.26 ARID1A ESR2 HNF1B TRERF1
2 intracellular estrogen receptor signaling pathway GO:0030520 8.62 ARID1A ESR2

Sources for Endometriosis of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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