MCID: END011
MIFTS: 43

Endometriosis of Ovary

Categories: Reproductive diseases, Endocrine diseases

Aliases & Classifications for Endometriosis of Ovary

MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 73
Ovarian Endometriosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11432
ICD10 33 N80.1
ICD9CM 35 617.1
NCIt 50 C27628
UMLS 73 C0156344

Summaries for Endometriosis of Ovary

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to adenomyosis and vaginitis. An important gene associated with Endometriosis of Ovary is LINC00339 (Long Intergenic Non-Protein Coding RNA 339), and among its related pathways/superpathways are Gastric cancer and Nuclear Receptor transcription pathway. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and uterus, and related phenotypes are endocrine/exocrine gland and muscle

Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 30.5 ESR1 PGR
2 vaginitis 30.5 ESR1 ESR2
3 endometrial adenocarcinoma 30.2 ESR1 ESR2 PGR
4 endometriosis 30.1 CYP19A1 ESR1 ESR2 HOXA10 PGR
5 infertility 30.0 CYP19A1 ESR2 PGR
6 endometrial stromal sarcoma 29.9 CYP19A1 ESR1 PGR
7 leiomyoma 29.7 CYP19A1 ESR1 ESR2 PGR
8 postmenopausal atrophic vaginitis 10.8 ESR1 ESR2
9 vulvar syringoma 10.7 ESR1 PGR
10 lung leiomyoma 10.7 ESR1 PGR
11 dental fluorosis 10.7 ESR1 ESR2
12 vestibular gland benign neoplasm 10.7 ESR1 PGR
13 bartholin's gland adenoma 10.7 ESR1 PGR
14 glassy cell carcinoma of the cervix 10.7 ESR1 PGR
15 vulvar benign neoplasm 10.7 ESR1 PGR
16 trigonitis 10.7 ESR1 PGR
17 vulvar leiomyoma 10.7 ESR1 PGR
18 predominantly cortical thymoma 10.7 ESR1 PGR
19 breast medullary carcinoma 10.7 ESR1 PGR
20 breast scirrhous carcinoma 10.7 ESR1 PGR
21 cribriform carcinoma 10.7 ESR1 PGR
22 oncocytic breast carcinoma 10.7 ESR1 PGR
23 endometrial squamous cell carcinoma 10.7 ESR1 PGR
24 gastric signet ring cell adenocarcinoma 10.7 ESR1 PGR
25 endometrial mucinous adenocarcinoma 10.7 ESR1 PGR
26 adenoid basal cell carcinoma 10.7 ESR1 PGR
27 apocrine adenocarcinoma 10.7 ESR1 PGR
28 lobular neoplasia 10.7 ESR1 ESR2
29 bartholin's gland benign neoplasm 10.7 ESR1 PGR
30 deep angioma 10.7 ESR1 PGR
31 synchronous bilateral breast carcinoma 10.7 ESR1 PGR
32 transsexualism 10.7 CYP19A1 ESR2
33 breast adenoid cystic carcinoma 10.7 ESR1 PGR
34 cervical carcinosarcoma 10.6 ESR1 PGR
35 intramuscular hemangioma 10.6 ESR1 PGR
36 glycogen-rich clear cell breast carcinoma 10.6 ESR1 PGR
37 retinitis pigmentosa 47 10.6 ESR1 PGR
38 uterine corpus cancer 10.6 ESR1 PGR
39 estrogen resistance 10.6 ESR1 TRERF1
40 retinitis pigmentosa 20 10.6 ESR1 PGR
41 luminal breast carcinoma 10.6 ESR1 PGR
42 adenosarcoma 10.6 ESR1 PGR
43 cervical clear cell adenocarcinoma 10.6 ESR1 PGR
44 breast benign neoplasm 10.6 ESR1 PGR
45 thoracic benign neoplasm 10.6 ESR1 PGR
46 benign metastasizing leiomyoma 10.6 CYP19A1 PGR
47 inflammatory breast carcinoma 10.6 ESR1 PGR
48 mixed cell type cancer 10.5 ESR1 PGR
49 lipid-rich carcinoma 10.5 ESR1 PGR
50 endometrial stromal nodule 10.5 CYP19A1 PGR

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Endometriosis of Uterus Fallopian Tube Endometriosis
Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary

Symptoms & Phenotypes for Endometriosis of Ovary

MGI Mouse Phenotypes related to Endometriosis of Ovary:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.86 HOXA10 PGR AMH ARID1A CYP19A1 ESR1
2 muscle MP:0005369 9.63 PGR ARID1A CYP19A1 ESR1 ESR2 HNF1B
3 neoplasm MP:0002006 9.35 PGR AMH ARID1A ESR1 ESR2
4 reproductive system MP:0005389 9.17 HOXA10 PGR AMH ARID1A CYP19A1 ESR1

Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 47725 5311128
3 Antineoplastic Agents, Hormonal Phase 4,Phase 2
4 Aromatase Inhibitors Phase 4
5 Estrogen Antagonists Phase 4
6 Estrogens Phase 4
7 Hormone Antagonists Phase 4
8 Hormones Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Steroid Synthesis Inhibitors Phase 4
11
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
12 Contraceptive Agents Phase 2
13 Contraceptive Agents, Male Phase 2
14
Medroxyprogesterone Phase 2 520-85-4 10631
15
Edetic Acid Approved, Vet_approved Not Applicable 60-00-4, 62-33-9 6049
16
Pentetic acid Approved Not Applicable 67-43-6
17 Anesthetics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 PGL5001 Proof of Concept Study in Inflammatory Endometriosis Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis Not yet recruiting NCT03481842 Phase 1, Phase 2 BIBW2992;Axitinib
4 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
5 Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients Completed NCT02984774 Not Applicable
6 Artificial Reproductive Techniques (ART) and Progression of Endometriosis Symptoms Completed NCT02762461
7 Perinatal Consequences of Endometriosis Recruiting NCT02498691 Not Applicable
8 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma Not yet recruiting NCT03430609 Not Applicable

Search NIH Clinical Center for Endometriosis of Ovary

Genetic Tests for Endometriosis of Ovary

Anatomical Context for Endometriosis of Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

41
Ovary, Endothelial, Uterus, Cervix, Cortex, Liver, Smooth Muscle

Publications for Endometriosis of Ovary

Articles related to Endometriosis of Ovary:

(show top 50) (show all 184)
# Title Authors Year
1
Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma. ( 28930811 )
2017
2
Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization. ( 28931865 )
2017
3
Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis. ( 27694140 )
2017
4
Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis. ( 27646154 )
2016
5
EP27.12: EndometriomaA -A the tip of a pelvic disease: TVS findings associated with an ovarian endometriosis. ( 27647664 )
2016
6
The co-expression of GPER and Gankyrin in ovarian endometriosis and its correlation with the rASRM stages. ( 26193952 )
2016
7
Increased Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Patients With Ovarian Endometriosis. ( 26342048 )
2016
8
Persistent Mullerian Duct Syndrome with Ovarian Endometriosis-A Rare Case Report. ( 27042476 )
2016
9
Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis. ( 28974971 )
2016
10
Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53 and heme oxygenase-1. ( 25772769 )
2015
11
Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2I+ biosynthesis and action in ovarian endometriosis tissue and in model cell lines. ( 25446850 )
2015
12
MiR-191 inhibits TNF-I+ induced apoptosis of ovarian endometriosis and endometrioid carcinoma cells by targeting DAPK1. ( 26191186 )
2015
13
Phospholipase A2 group IIA is elevated in endometriomas but not in peritoneal fluid and serum of ovarian endometriosis patients. ( 25366587 )
2014
14
RUNX3 is inactivated by promoter hypermethylation in malignant transformation of ovarian endometriosis. ( 25333219 )
2014
15
Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis. ( 25150394 )
2014
16
Genome-wide profiling of long noncoding ribonucleic acid expression patterns in ovarian endometriosis by microarray. ( 24502888 )
2014
17
Increased expression of the pluripotency markers sex-determining region Y-box 2 and Nanog homeobox in ovarian endometriosis. ( 24884521 )
2014
18
Tubal origin of ovarian endometriosis. ( 24390223 )
2014
19
Surgically treated ovarian endometriosis association with BRCA1 and BRCA2 mutations. ( 24472143 )
2014
20
MicroRNA23a and microRNA23b deregulation derepresses SF-1 and upregulates estrogen signaling in ovarian endometriosis. ( 23450049 )
2013
21
High-resolution array-comparative genomic hybridization profiling reveals 20q13.33 alterations associated with ovarian endometriosis. ( 23656391 )
2013
22
MicroRNAs expression profiling of eutopic proliferative endometrium in women with ovarian endometriosis. ( 23945042 )
2013
23
Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis. ( 23461865 )
2013
24
Long term survival of ovarian endometriosis associated clear cell and endometrioid ovarian cancers. ( 23314280 )
2013
25
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: a source of excessive hydroxy-estrogens and ROS? ( 23277161 )
2013
26
Loss of ARID1A/BAF250a expression in ovarian endometriosis and clear cell carcinoma. ( 22977660 )
2012
27
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis. ( 21944080 )
2012
28
The G-protein-coupled estrogen receptor (GPER) is expressed in normal human ovaries and is upregulated in ovarian endometriosis and pelvic inflammatory disease involving the ovary. ( 22573494 )
2012
29
Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis. ( 23113924 )
2012
30
The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis. ( 22633261 )
2012
31
Involvement of pelvic inflammation-related mismatch repair abnormalities and microsatellite instability in the malignant transformation of ovarian endometriosis. ( 22626277 )
2012
32
Epigenetic inactivation of hMLH1 in the malignant transformation of ovarian endometriosis. ( 21556900 )
2012
33
Genetic polymorphisms of DNMT3L involved in hypermethylation of chromosomal ends are associated with greater risk of developing ovarian endometriosis. ( 22401780 )
2012
34
Fertility preservation in women with ovarian endometriosis. ( 22201982 )
2012
35
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. ( 22611972 )
2012
36
Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis. ( 22859507 )
2012
37
Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis. ( 21232532 )
2011
38
Follicular loss in endoscopic surgery for ovarian endometriosis: quantitative and qualitative observations. ( 21703608 )
2011
39
Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis. ( 21130491 )
2011
40
Primary squamous cell carcinoma associated with ovarian endometriosis: a case report and literature review. ( 21301917 )
2011
41
Frequency of ovarian endometriosis in epithelial ovarian cancer patients. ( 22268283 )
2011
42
Involvement of estrogen receptor-related receptors in human ovarian endometriosis. ( 21561608 )
2011
43
Expression patterns of the steroid receptor coactivator family in human ovarian endometriosis. ( 21518137 )
2011
44
Two-dimensional gel electrophoresis in peritoneal fluid samples identifies differential protein regulation in patients suffering from peritoneal or ovarian endometriosis. ( 21497343 )
2011
45
Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis. ( 21397694 )
2011
46
Identification of cells with colony-forming activity, self-renewal capacity, and multipotency in ovarian endometriosis. ( 21641404 )
2011
47
Immunohistochemical detection of steroid receptor cofactors in ovarian endometriosis: involvement of down-regulated SRC-1 expression in the limited growth activity of the endometriotic epithelium. ( 20155281 )
2010
48
Steroidogenic factor-1 expression in ovarian endometriosis. ( 19875956 )
2010
49
Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis. ( 19956897 )
2010
50
Immunohistochemical expression of matrix metalloproteinases, their tissue inhibitors, and cathepsin-D in ovarian endometriosis: correlation with severity of disease. ( 20385381 )
2010

Variations for Endometriosis of Ovary

Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

Pathways for Endometriosis of Ovary

GO Terms for Endometriosis of Ovary

Cellular components related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 HNF1B HOXA10 TRERF1

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.98 ARID1A ESR1 ESR2 HNF1B HOXA10 PGR
2 positive regulation of transcription, DNA-templated GO:0045893 9.72 ARID1A ESR1 ESR2 HNF1B TRERF1
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.63 ESR1 ESR2 PGR
4 mammary gland development GO:0030879 9.51 CYP19A1 PGR
5 regulation of Wnt signaling pathway GO:0030111 9.48 ESR1 HNF1B
6 steroid biosynthetic process GO:0006694 9.43 CYP19A1 HSD17B2 TRERF1
7 androgen metabolic process GO:0008209 9.4 CYP19A1 ESR1
8 estrogen biosynthetic process GO:0006703 9.37 CYP19A1 HSD17B2
9 steroid hormone mediated signaling pathway GO:0043401 9.33 ESR1 ESR2 PGR
10 intracellular estrogen receptor signaling pathway GO:0030520 9.13 ARID1A ESR1 ESR2
11 uterus development GO:0060065 8.8 CYP19A1 ESR1 HOXA10
12 regulation of transcription, DNA-templated GO:0006355 10.04 ARID1A ESR1 ESR2 HNF1B HOXA10 PGR

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.95 ARID1A ESR1 ESR2 HNF1B HOXA10 PGR
2 sequence-specific DNA binding GO:0043565 9.83 ESR1 ESR2 HNF1B HOXA10 PGR
3 steroid hormone receptor activity GO:0003707 9.54 ESR1 ESR2 PGR
4 nuclear receptor activity GO:0004879 9.33 ESR1 ESR2 PGR
5 estrogen receptor activity GO:0030284 9.32 ESR1 ESR2
6 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
7 steroid binding GO:0005496 9.13 ESR1 ESR2 PGR
8 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.62 ESR1 ESR2
9 DNA binding GO:0003677 10 ARID1A ESR1 ESR2 HNF1B HOXA10 PGR

Sources for Endometriosis of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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