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MCID: END011
MIFTS: 46

Endometriosis of Ovary

Categories: Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endometriosis of Ovary

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MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 73
Ovarian Endometriosis 12

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:11432
ICD10 33 N80.1
ICD9CM 35 617.1
NCIt 50 C27628
SNOMED-CT 68 31007005
UMLS 73 C0156344
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Summaries for Endometriosis of Ovary

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Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and diffuse peritoneal leiomyomatosis. An important gene associated with Endometriosis of Ovary is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are Gastric cancer and Nuclear Receptor transcription pathway. The drugs Goserelin and Anastrozole have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related phenotypes are endocrine/exocrine gland and muscle

Wikipedia : 76 Endometrioma is the presence of endometrial tissue in and sometimes on the ovary. More broadly,... more...

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Related Diseases for Endometriosis of Ovary

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Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 endometriosis 31.2 CYP19A1 ESR1 ESR2 HOXA10 PGR
2 diffuse peritoneal leiomyomatosis 30.0 ESR1 PGR
3 leiomyoma 29.9 CYP19A1 ESR1 ESR2 PGR
4 endometrial stromal sarcoma 29.8 CYP19A1 ESR1 PGR
5 ovary adenocarcinoma 29.8 ARID1A HNF1B
6 adenomyosis 29.8 CYP19A1 ESR1 HOXA10 PGR
7 endometrial adenocarcinoma 29.7 ESR1 ESR2 HOXA10 PGR
8 ovarian disease 29.5 AMH CYP19A1 ESR1 ESR2 PGR
9 extrapelvic endometriosis 10.3
10 postmenopausal atrophic vaginitis 10.3 ESR1 ESR2
11 vaginitis 10.3 ESR1 ESR2
12 dental fluorosis 10.2 ESR1 ESR2
13 vestibular gland benign neoplasm 10.2 ESR1 PGR
14 bartholin's gland adenoma 10.2 ESR1 PGR
15 vulvar syringoma 10.2 ESR1 PGR
16 glassy cell carcinoma of the cervix 10.2 ESR1 PGR
17 lung leiomyoma 10.2 ESR1 PGR
18 vulvar benign neoplasm 10.2 ESR1 PGR
19 trigonitis 10.2 ESR1 PGR
20 vulvar leiomyoma 10.2 ESR1 PGR
21 lobular neoplasia 10.2 ESR1 ESR2
22 predominantly cortical thymoma 10.2 ESR1 PGR
23 breast medullary carcinoma 10.2 ESR1 PGR
24 breast scirrhous carcinoma 10.2 ESR1 PGR
25 bartholin's gland benign neoplasm 10.2 ESR1 PGR
26 oncocytic breast carcinoma 10.2 ESR1 PGR
27 endometrial squamous cell carcinoma 10.2 ESR1 PGR
28 cribriform carcinoma 10.2 ESR1 PGR
29 uterine body mixed cancer 10.2 ARID1A PGR
30 endometrial mucinous adenocarcinoma 10.2 ESR1 PGR
31 adenoid basal cell carcinoma 10.2 ESR1 PGR
32 transsexualism 10.2 CYP19A1 ESR2
33 breast adenoid cystic carcinoma 10.2 ESR1 PGR
34 apocrine adenocarcinoma 10.2 ESR1 PGR
35 peritoneal benign neoplasm 10.2 ESR1 PGR
36 deep angioma 10.2 ESR1 PGR
37 synchronous bilateral breast carcinoma 10.2 ESR1 PGR
38 female reproductive endometrioid cancer 10.2 ESR1 PGR
39 cervical carcinosarcoma 10.2 ESR1 PGR
40 intramuscular hemangioma 10.2 ESR1 PGR
41 estrogen resistance 10.2 ESR1 TRERF1
42 ovarian cancer 10.2
43 adenocarcinoma 10.2
44 glycogen-rich clear cell breast carcinoma 10.2 ESR1 PGR
45 cervical clear cell adenocarcinoma 10.2 ESR1 PGR
46 retinitis pigmentosa 47 10.2 ESR1 PGR
47 inflammatory breast carcinoma 10.2 ESR1 PGR
48 retinitis pigmentosa 20 10.2 ESR1 PGR
49 adenosarcoma 10.2 ESR1 PGR
50 luminal breast carcinoma 10.2 ESR1 PGR

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Fallopian Tube Endometriosis Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary
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Symptoms & Phenotypes for Endometriosis of Ovary

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MGI Mouse Phenotypes related to Endometriosis of Ovary:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.86 AMH ARID1A CYP19A1 ESR1 ESR2 HNF1B
2 muscle MP:0005369 9.63 ARID1A CYP19A1 ESR1 ESR2 HNF1B PGR
3 neoplasm MP:0002006 9.35 AMH ARID1A ESR1 ESR2 PGR
4 reproductive system MP:0005389 9.23 AKR1C3 AMH ARID1A CYP19A1 ESR1 ESR2
Sources

Drugs & Therapeutics for Endometriosis of Ovary

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Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Goserelin Approved Phase 4 65807-02-5 47725 5311128
2
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
3 Antineoplastic Agents, Hormonal Phase 4,Phase 2
4 Estrogen Receptor Antagonists Phase 4
5 Steroid Synthesis Inhibitors Phase 4
6 Estrogens Phase 4
7 Estrogen Antagonists Phase 4
8 Hormone Antagonists Phase 4,Not Applicable
9 Hormones Phase 4,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
11 Aromatase Inhibitors Phase 4
12
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
13
Axitinib Approved, Investigational Phase 1, Phase 2 319460-85-0 6450551
14 Contraceptive Agents, Male Phase 2
15 Contraceptive Agents Phase 2
16
Medroxyprogesterone Phase 2 520-85-4 10631
17 Protein Kinase Inhibitors Phase 1, Phase 2
18
Pentetic acid Approved Not Applicable 67-43-6
19
Edetic Acid Approved, Vet_approved Not Applicable 62-33-9, 60-00-4 6049
20 Anesthetics Not Applicable
21 Follicle Stimulating Hormone Not Applicable
22 Coagulants Not Applicable
23 Hemostatics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 PGL5001 Proof of Concept Study in Inflammatory Endometriosis Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis Not yet recruiting NCT03481842 Phase 1, Phase 2 BIBW2992;Axitinib
4 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
5 Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients Completed NCT02984774 Not Applicable
6 Artificial Reproductive Techniques (ART) and Progression of Endometriosis Symptoms Completed NCT02762461
7 Perinatal Consequences of Endometriosis Active, not recruiting NCT02498691 Not Applicable
8 Oxidative Stress Gene Polymorphism and Ovarian Reserve Functione Not yet recruiting NCT03682341
9 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma Not yet recruiting NCT03430609 Not Applicable

Search NIH Clinical Center for Endometriosis of Ovary

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Genetic Tests for Endometriosis of Ovary

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Anatomical Context for Endometriosis of Ovary

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MalaCards organs/tissues related to Endometriosis of Ovary:

41
Ovary, Uterus, Cervix, Smooth Muscle, Lung, Breast, Prostate

The Foundational Model of Anatomy Ontology organs/tissues related to Endometriosis of Ovary:

19
The Ovary
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Publications for Endometriosis of Ovary

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Articles related to Endometriosis of Ovary:

(show top 50) (show all 243)
# Title Authors Year
1
Ovarian endometriosis and infertility: in vitro fertilization (IVF) or surgery as the first approach? ( 30503109 )
2018
2
Comparison of Outcomes of Different Postoperative Hormone Therapy in the Treatment of Ovarian Endometriosis: A Brief Report. ( 29873006 )
2018
3
Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis. ( 29920364 )
2018
4
Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis. ( 29928437 )
2018
5
Ovarian endometriosis and fertility preservation: a challenge in 2018. ( 29644329 )
2018
6
Decreased Expression of HOXA10 May Activate the Autophagic Process in Ovarian Endometriosis. ( 29658437 )
2018
7
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis. ( 29669342 )
2018
8
Ovarian endometriosis: risk factor analysis and prediction of malignant transformation. ( 29725285 )
2018
9
A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis. ( 29738836 )
2018
10
Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis. ( 29763921 )
2018
11
Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over. ( 29786043 )
2018
12
Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization. ( 29806498 )
2018
13
G protein‑coupled estrogen receptor/miR‑148a/human leukocyte antigen‑G signaling pathway mediates cell apoptosis of ovarian endometriosis. ( 29845209 )
2018
14
Novel CTCF mutations in Chinese patients with ovarian endometriosis. ( 29845264 )
2018
15
Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. ( 29483390 )
2018
16
The Relationship of Circular RNAs With Ovarian Endometriosis. ( 29490568 )
2018
17
The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis. ( 29547736 )
2018
18
Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated? ( 29551389 )
2018
19
EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression. ( 29558202 )
2018
20
Immunohistochemical Features of O6-Methylguanine-DNA Methyltransferase Expression during Ovarian Endometriosis. ( 29308563 )
2018
21
Circular RNA expression in ovarian endometriosis. ( 29334789 )
2018
22
Integration analysis of microRNA and mRNA paired expression profiling identifies deregulated microRNA-transcription factor-gene regulatory networks in ovarian endometriosis. ( 29357938 )
2018
23
Novel TRERF1 mutations in Chinese patients with ovarian endometriosis. ( 29393434 )
2018
24
Factors that Differentiate between Endometriosis-associated Ovarian Cancer and Benign Ovarian Endometriosis with Mural Nodules. ( 28824051 )
2018
25
Pelvic floor muscle assessment on three- and four-dimensional transperineal ultrasound in women with ovarian endometriosis with or without retroperitoneal infiltration: a step towards complete functional assessment. ( 29024196 )
2018
26
Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma. ( 28930811 )
2017
27
Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization. ( 28931865 )
2017
28
Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis. ( 27694140 )
2017
29
Endometrioid adenocarcinoma originating simultaneously from endometrium, sites of adenomyosis and ovarian endometriosis: A case report and review of our cancer database. ( 29096350 )
2017
30
Diagnostic performance of human epididymis protein 4 compared to a combination of biophysical and biochemical markers to differentiate ovarian endometriosis from epithelial ovarian cancer in premenopausal women. ( 29027715 )
2017
31
Ovarian endometriosis during pregnancy: a series of 53 endometriomas. ( 26482730 )
2017
32
Aberrant Methylation of the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endometriosis. ( 27023436 )
2017
33
Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population. ( 27233752 )
2017
34
Ovarian endometriosis and vitamin D serum levels. ( 27809683 )
2017
35
Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis. ( 27928852 )
2017
36
Ten Principles for Safe Surgical Treatment of Ovarian Endometriosis. ( 27932268 )
2017
37
A case of spontaneous abortion related to ovarian endometriosis in a Golden Retriever dog. ( 28588636 )
2017
38
Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis. ( 27646154 )
2016
39
EP27.12: EndometriomaA -A the tip of a pelvic disease: TVS findings associated with an ovarian endometriosis. ( 27647664 )
2016
40
The co-expression of GPER and Gankyrin in ovarian endometriosis and its correlation with the rASRM stages. ( 26193952 )
2016
41
Increased Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Patients With Ovarian Endometriosis. ( 26342048 )
2016
42
Persistent Mullerian Duct Syndrome with Ovarian Endometriosis-A Rare Case Report. ( 27042476 )
2016
43
Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis. ( 28974971 )
2016
44
Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients. ( 26921767 )
2016
45
Performance of Circulating Placental Growth Factor as A Screening Marker for Diagnosis of Ovarian Endometriosis: A Pilot Study. ( 26985335 )
2016
46
Assessment of ovarian reserve in patients with ovarian endometriosis following laparoscopic enucleation of a cyst accompanied by COâ‚‚ laser ablation or electroablation. ( 27120941 )
2016
47
Differential studies of ovarian endometriosis cells from endometrium or oviduct. ( 27424973 )
2016
48
Autophagy is upregulated in ovarian endometriosis: a possible interplay with p53 and heme oxygenase-1. ( 25772769 )
2015
49
Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2I+ biosynthesis and action in ovarian endometriosis tissue and in model cell lines. ( 25446850 )
2015
50
Susceptibility-weighted MRI of extra-ovarian endometriosis: preliminary results. ( 25682291 )
2015
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Variations for Endometriosis of Ovary

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Expression for Endometriosis of Ovary

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Search GEO for disease gene expression data for Endometriosis of Ovary.
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Pathways for Endometriosis of Ovary

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Pathways related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Gastric cancer 37
Show member pathways
 12.37 ARID1A ESR1 ESR2 PGR
2
Nuclear Receptor transcription pathway 66
Show member pathways
 11.45 ESR1 ESR2 PGR
3
Steroid hormone biosynthesis 37
Show member pathways
 11.25 AKR1C3 CYP19A1 HSD17B2
4
Ovarian steroidogenesis 37
11.02 AKR1C3 CYP19A1 HSD17B2
5
Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 22
10.9 ESR1 ESR2
6
Plasma membrane estrogen receptor signaling 1
10.85 ESR1 ESR2
7
MNAR-PELP1 and Estrogen Receptor Interaction 64
10.73 ESR1 ESR2
8
Ovarian Infertility Genes 1
10.64 CYP19A1 ESR2 PGR
9
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 61
9.4 CYP19A1 ESR1 ESR2
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GO Terms for Endometriosis of Ovary

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Cellular components related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 HNF1B HOXA10 TRERF1

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.72 ARID1A ESR1 ESR2 HNF1B TRERF1
2 transcription, DNA-templated GO:0006351 9.69 ESR1 ESR2 PGR
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.63 ESR1 ESR2 PGR
4 male gonad development GO:0008584 9.54 AKR1C3 ESR1 HOXA10
5 mammary gland development GO:0030879 9.49 CYP19A1 PGR
6 regulation of Wnt signaling pathway GO:0030111 9.48 ESR1 HNF1B
7 androgen metabolic process GO:0008209 9.43 CYP19A1 ESR1
8 estrogen biosynthetic process GO:0006703 9.4 CYP19A1 HSD17B2
9 steroid biosynthetic process GO:0006694 9.33 CYP19A1 HSD17B2 TRERF1
10 testosterone biosynthetic process GO:0061370 9.26 AKR1C3 CYP19A1
11 intracellular estrogen receptor signaling pathway GO:0030520 9.13 ARID1A ESR1 ESR2
12 uterus development GO:0060065 8.8 CYP19A1 ESR1 HOXA10

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.95 ARID1A ESR1 ESR2 HNF1B HOXA10 PGR
2 DNA-binding transcription factor activity GO:0003700 9.89 ESR1 ESR2 HNF1B PGR TRERF1
3 sequence-specific DNA binding GO:0043565 9.85 ESR1 ESR2 HNF1B HOXA10 PGR
4 oxidoreductase activity GO:0016491 9.83 AKR1C3 CYP19A1 FMO3 HSD17B2
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.81 ESR1 ESR2 HOXA10 PGR
6 steroid hormone receptor activity GO:0003707 9.5 ESR1 ESR2 PGR
7 testosterone dehydrogenase (NAD+) activity GO:0047035 9.43 AKR1C3 HSD17B2
8 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
9 nuclear receptor activity GO:0004879 9.33 ESR1 ESR2 PGR
10 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
11 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
12 steroid binding GO:0005496 8.8 ESR1 ESR2 PGR
13 DNA binding GO:0003677 10.02 ARID1A ESR1 ESR2 HNF1B HOXA10 PGR
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Sources for Endometriosis of Ovary

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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