Endometriosis of Ovary disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and ovarian cyst. An important gene associated with Endometriosis of Ovary is MIR141 (MicroRNA 141), and among its related pathways/superpathways are Breast cancer pathway and Nuclear receptors. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial, and related phenotypes are neoplasm and no phenotypic analysis

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Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)

#	Related Disease	Score	Top Affiliating Genes
1	endometriosis	31.3	PGR MIR424 MIR199A1 MIR145 MIR141 GNRH1
2	ovarian cyst	30.7	PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
3	infertility	30.6	PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
4	leiomyoma	30.5	PGR GNRH1 ESR2 ESR1 CYP19A1
5	progesterone resistance	30.5	PGR ESR2 ESR1
6	ovarian clear cell carcinoma	30.4	PIK3CA MIR9-1 MIR424 MIR221 MIR199A1 ARID1A
7	serous cystadenocarcinoma	30.4	PIK3CA PGR MIR199A1 ESR1 ARID1A
8	leiomyomatosis	30.4	PGR GNRH1 ESR1
9	papillary serous adenocarcinoma	30.4	PGR MIR145 ESR1
10	leiomyoma, uterine	30.3	PGR GNRH1 ESR2 ESR1 CYP19A1
11	myoma	30.3	PGR GNRH1 ESR1 CYP19A1 AMH
12	cystadenocarcinoma	30.2	PGR MIR199A1 ESR2 ARID1A
13	clear cell adenofibroma	30.2	PIK3CA ARID1A
14	diffuse peritoneal leiomyomatosis	30.2	PGR GNRH1 ESR1 CYP19A1
15	endometrial stromal sarcoma	30.1	PGR ESR2 ESR1 CYP19A1
16	pseudohermaphroditism	30.1	GNRH1 CYP19A1 AMH
17	endometrial adenocarcinoma	30.1	PGR MIR199A1 ESR1
18	hyperandrogenism	30.1	GNRH1 CYP19A1 AMH
19	endometrial cancer	30.1	PIK3CA PGR MIR199A1 MIR145 MIR141 GNRH1
20	premature menopause	30.0	PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
21	colonic benign neoplasm	30.0	PIK3CA MIR199A1 MIR145 ESR1
22	adenomyoma	30.0	PGR GNRH1 ESR1 AMH
23	intestinal disease	29.9	MIR9-1 MIR424 MIR221 MIR199A1 MIR145 MIR141
24	ovary adenocarcinoma	29.9	PIK3CA PGR ESR1 ARID1A
25	ovarian cancer	29.8	PIK3CA PGR MIR9-1 MIR424 MIR221 MIR199A1
26	endometrial hyperplasia	29.8	PGR ESR2 ESR1 CYP19A1 ARID1A
27	male infertility	29.6	MIR510 GNRH1 ESR2 ESR1 CYP19A1 AMH
28	estrogen excess	29.6	PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
29	ovarian disease	29.3	PGR MIR9-1 MIR424 MIR221 MIR199A1 MIR145
30	epithelial-myoepithelial carcinoma	10.4
31	adenomyosis	10.4
32	cervix small cell carcinoma	10.4	MIR199A1 MIR145
33	rectum carcinoma in situ	10.4	ESR2 ESR1
34	nonmucinous bronchioloalveolar adenocarcinoma	10.4	ESR2 ESR1
35	ovarian serous carcinoma	10.3	MIR199A1 MIR145 MIR141
36	nipple carcinoma	10.3	PGR ESR1
37	bartholin's gland adenoma	10.3	PGR ESR1
38	uterine corpus adenosarcoma	10.3	PGR ESR1
39	breast mucinous cystadenocarcinoma	10.3	PGR ESR1
40	bartholin's gland benign neoplasm	10.3	PGR ESR1
41	breast fibroadenosis	10.3	PGR ESR1
42	vestibular gland benign neoplasm	10.3	PGR ESR1
43	uterine sarcoma	10.3	ESR1 CYP19A1
44	lung leiomyoma	10.3	PGR MIR221
45	bulbospinal polio	10.3	PGR ESR1
46	spinal polio	10.3	PGR ESR1
47	glycogen-rich clear cell breast carcinoma	10.3	PGR ESR1
48	adult cystic nephroma	10.3	PGR ESR1
49	breast cystic hypersecretory carcinoma	10.3	PGR ESR1
50	vagina leiomyosarcoma	10.3	PGR ESR1

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):

Adenomyosis	Fallopian Tube Endometriosis
Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:

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Symptoms & Phenotypes for Endometriosis of Ovary

MGI Mouse Phenotypes related to Endometriosis of Ovary:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.5	AMH ARID1A ESR1 ESR2 GNRH1 PGR
2	no phenotypic analysis	MP:0003012	9.28	AMH ARID1A ESR1 ESR2 MIR199A1 MIR424

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Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Anastrozole

Approved, Investigational

Phase 4

120511-73-1

2187

2

Goserelin

Approved

Phase 4

65807-02-5

5311128 47725

3

Antineoplastic Agents, Hormonal

Phase 4

4

Estrogens

Phase 4

5

Estrogen Receptor Antagonists

Phase 4

6

Estrogen Antagonists

Phase 4

7

Hormones

Phase 4

8

Hormone Antagonists

Phase 4

9

Aromatase Inhibitors

Phase 4

10

Medroxyprogesterone acetate

Approved, Investigational

Phase 2

520-85-4, 71-58-9

6279 10631

Synonyms:

(6ALPHA)-17-(ACETYLOXY)-6-METHYLPREG-4-ENE-3,20-DIONE

(6α)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione

17 alpha Hydroxy 6 alpha methylprogesterone

17 alpha-Hydroxy-6 alpha-methylprogesterone

17-ACETOXY-6ALPHA-METHYLPROGESTERONE

17-ACETOXY-6Α-METHYLPROGESTERONE

17a-Hydroxy-6a-methylprogesterone

17alpha-Hydroxy-6alpha-methylprogesterone

17ALPHA-HYDROXY-6ALPHA-METHYLPROGESTERONE ACETATE

17-Hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione

17-Hydroxy-6alpha-methylprogesterone

17-Hydroxy-6a-methyl-pregn-4-ene-3,20-dione

17-Hydroxy-6a-methylprogesterone

17-Hydroxy-6α-methyl-pregn-4-ene-3,20-dione

17-Hydroxy-6α-methylprogesterone

17Α-hydroxy-6α-methylprogesterone

17Α-HYDROXY-6Α-METHYLPROGESTERONE ACETATE

6ALPHA-METHYL-17-ACETOXY PROGESTERONE

6-ALPHA-METHYL-17-ALPHA-ACETOXYPROGESTERONE

6alpha-Methyl-17alpha-hydroxyprogesterone

6ALPHA-METHYL-17ALPHA-HYDROXYPROGESTERONE ACETATE

6-ALPHA-METHYL-17-ALPHA-HYDROXYPROGESTERONE ACETATE

6alpha-Methyl-4-pregnen-17alpha-ol-3,20-dione

6ALPHA-METHYL-4-PREGNENE-3,20-DION-17ALPHA-OL ACETATE

6a-Methyl-17a-hydroxyprogesterone

6a-Methyl-4-pregnen-17a-ol-3,20-dione

6Α-METHYL-17-ACETOXY PROGESTERONE

6Α-methyl-17α-hydroxyprogesterone

6Α-METHYL-17Α-HYDROXYPROGESTERONE ACETATE

6Α-methyl-4-pregnen-17α-ol-3,20-dione

6α-Methyl-4-pregnene-3,20-dion-17α-ol acetate

ADGYN MEDRO

AMEN

Aragest

Aragest 5

Asconale

CBP-1011

CLIMANOR

Clinofem

Clinovir

Colirest

CURRETAB

CYCRIN

Depo-Clinovir

Depo-Prodasone

Depo-Progestin

DEPO-PROGEVERA

Depo-Promone

DEPO-PROVERA

DEPO-PROVERA ONCOLOGY

DEPO-SUBQ PROVERA 104

Depot-Medroxyprogesterone acetate

DMPA

FARLUTAL

FARLUTAL 100

FARLUTAL 200

FARLUTAL 250

FARLUTAL 500

Farlutal inyectable

Farlutin

Gestapuran

G-Farlutal

Hematrol

Hydroxymethylprogesterone

hydroxymethylprogesterone|MPA

Hysron

Indivina

LUNELLE

Lutopolar

Lutoral

MAP

Med-Pro

Medroprogesterone Acetate

Medrossiprogesterone

Medrossiprogesterone [Dcit]

Medroxiprogesterona

Medroxiprogesterona [INN-Spanish]

MEDROXIPROGESTERONE ACETATE

Medroxiprogesteronum

MEDROXYACETATE PROGESTERONE

Medroxyprogesteron

Medroxyprogesteron acetate

MEDROXYPROGESTERONE

MEDROXYPROGESTERONE 17-ACETATE

MEDROXYPROGESTERONE ACETATE

Medroxyprogesterone strakan brand

Medroxyprogesteronum

Medroxyprogesteronum [INN-Latin]

Meprate

METHYLACETOXYPROGESTERONE

Methylhydroxyprogesterone

METIGESTRONA

MPA

MPA Gyn 5

Nadigest

Nidaxin

Novo-Medrone

NSC-21171

NSC-26386

Oragest

Perlutex

Perlutex Leo

PREMPRO

Prodasone

Progestalfa

Progevera

PROVERA

Proverone

Ralovera

Repromap

Repromix

SAYANA PRESS

Sirprogen

Sodelut G

Strakan brand OF medroxyprogesterone

TV-46046

Veramix

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis	Completed	NCT00286351	Phase 4	Combined treatment with Arimidex and Zoladex before IVF
2	A Phase IIa Efficacy and Safety Study of PGL5001 Versus Placebo Administered for up to 5 Months With Concomitant Administration of Depot Medroxyprogesterone Acetate for the Treatment of Peritoneal and/or Ovarian Endometriosis With an Inflammatory Component.	Completed	NCT01630252	Phase 2	PGL5001;Placebo
3	Methylation of cfDNA in Diagnosis and Differential Diagnosis of Ovarian Endometriosis	Unknown status	NCT04220710
4	Evaluating Ovarian Reserve After Conventional Laparoscopy Versus Robotic Surgery for Bilateral Endometrioma: a Randomized Controlled Trial.	Recruiting	NCT05357924

Search NIH Clinical Center for Endometriosis of Ovary

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Genetic Tests for Endometriosis of Ovary

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Anatomical Context for Endometriosis of Ovary

Organs/tissues related to Endometriosis of Ovary:

FMA: Ovary

MalaCards : Ovary, Uterus, Endothelial, T Cells, Cervix, Appendix, Lymph Node

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Publications for Endometriosis of Ovary

Articles related to Endometriosis of Ovary:

(show top 50) (show all 941)

#	Title	Authors	PMID	Year
1	Influence of endometrioma size on ART outcomes. ⁶²	Bourdon M...Santulli P	36167632	2022
2	Three-Dimensional Ultrasound Evaluation of Pelvic Floor Muscle Contraction in Women Affected by Deep Infiltrating Endometriosis: Application of a Quick Contraction Scale. ⁶²	Arena A...Seracchioli R	35532292	2022
3	Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis. ⁶²	Shuang T...Li Q	35733415	2022
4	Knockdown of miR-150-5p reduces hypoxia-induced autophagy and epithelial-mesenchymal transition of endometriotic cells via regulating the PDCD4/NF-κB signaling pathway. ⁶²	Chen ML...Sun ZF	36427469	2022
5	Effect of PLGA Nanoparticle-Mediated Delivery of miRNA 503 on The Apoptosis of Ovarian Endometriosis Cells. ⁶²	Chaichian S...Eslahi N	36377220	2022
6	Elevated phosphorylation of estrogen receptor α at serine-118 in ovarian endometrioma. ⁶²	Sun H...Osuga Y	35654737	2022
7	Claudin-10 Expression Is Increased in Endometriosis and Adenomyosis and Mislocalized in Ectopic Endometriosis. ⁶²	Loeffelmann AC...Konrad L	36428908	2022
8	Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone. ⁶²	Pan Y...Shi H	36348508	2022
9	Pelvic floor dysfunction at transperineal ultrasound and chronic constipation in women with endometriosis. ⁶²	Raimondo D...Seracchioli R	34995357	2022
10	Surgically confirmed endometriosis in adolescents in Finland-A register-based cross-sectional cohort study. ⁶²	Rasp E...Rono K	35818936	2022
11	The comparison of two different protocols ultra-long versus medroxyprogesterone acetate in women with ovarian endometriosis: a prospective randomized controlled trial. ⁶²	Guo H...Zhu Q	36195878	2022
12	Integrated bioinformatic analysis of dysregulated microRNA-mRNA co-expression network in ovarian endometriosis. ⁶²	Liu Y...Lu D	35876135	2022
13	Effect of the mode of delivery on the risk of endometriosis recurrence: a retrospective cohort study. ⁶²	Delli Carpini G...Ciavattini A	36243596	2022
14	Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis. ⁶²	Shimura K...Mori T	36197633	2022
15	Cyclic hematochezia in young woman with appendiceal endometriosis. ⁶²	Ostiz Llanos M...Monzon Munoz FJ	36263823	2022
16	Clinical characteristics and surgical management of endometriosis-associated infertility: A multicenter prospective cohort study. ⁶²	Bhurke AV...Gajbhiye RK	35075631	2022
17	mRNA, lncRNA and Circular RNA Expression Profiles in Granulosa Cells of Infertile Women with Ovarian Endometriosis. ⁶²	Guo J...Peng J	35799021	2022
18	FOR: Fertility preservation for women with ovarian endometriosis: It is time to adopt it as routine practice. ⁶²	Latif S...Yasmin E	35434942	2022
19	Effects of EZH2 on Invasion and Migration of Endometrial Stromal Cells in Endometriosis Patients by Regulating PCDH10 Gene H3K27 Methylation. ⁶²	Xiaolei T...Jing Z	36239569	2022
20	Endometriosis: Cellular and Molecular Mechanisms Leading to Fibrosis. ⁶²	Garcia Garcia JM...Petraglia F	36289173	2022
21	Serum anti-Müllerian hormone recovery after ovarian cystectomy for endometriosis: A retrospective study among Korean women. ⁶²	Lee J...Hong DG	36221377	2022
22	Down-regulation of HLA-DRs and HLA-DPs reflects the deficiency of antigen-presenting cells in endometrium from infertile women with and without ovarian endometriosis. ⁶²	Jiang L...Fang X	33787425	2022
23	AGAINST: Fertility preservation for women with ovarian endometriosis: it is time to adopt this as routine practice. ⁶²	Hirsch M...Davies M	35614636	2022
24	Pregnancy following robot-assisted laparoscopic bilateral endometriotic cystectomy rare case report of endometriosis stage IV. ⁶²	Kyejo W...Kaguta M	35985118	2022
25	Novel missense variant of CIITA contributing to endometriosis. ⁶²	Zhu Y...Wang B	35835655	2022
26	IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6. ⁶²	Zhao S...Yaling F	36113831	2022
27	Potential clinical implications of iron metabolism in ovarian endometriosis. ⁶²	Liu MN...Zhang K	35763972	2022
28	Mixed Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) of the Ovary Arising from Endometriosis: Molecular Pathology Analysis in Support of a Pathogenetic Paradigm. ⁶²	Maragliano R...Uccella S	34342838	2022
29	Ovarian clear cell carcinoma arising in a large endometrioma - A case report with pathological correlation and literature review. ⁶²	Negrao E...Madureira AJ	35694637	2022
30	Whole-exome sequencing and functional validation reveal a rare missense variant in MMP7 that confers ovarian endometriosis risk. ⁶²	Liu F...Zou Y	35288736	2022
31	Unbiased In Silico Analysis of Gene Expression Pinpoints Circulating miRNAs Targeting KIAA1324, a New Gene Drastically Downregulated in Ovarian Endometriosis. ⁶²	Abo C...Borghese B	36140165	2022
32	The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. ⁶²	Xu X...Zhang X	35907907	2022
33	Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. ⁶²	Sapmaz T...Irkorucu O	35644046	2022
34	Sonographic features differentiating early-stage ovarian clear cell carcinoma from endometrioma with atypical features. ⁶²	Huang KJ...Sheu BC	35836288	2022
35	CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis. ⁶²	Tan J...Zhang Z	35841069	2022
36	Endometriosis is associated with a lowered cumulative live birth rate: A retrospective matched cohort study including 3071 in vitro fertilization cycles. ⁶²	Zhou L...Li L	35504114	2022
37	Cumulative Recurrence Rate and Risk Factors for Recurrent Abdominal Wall Endometriosis after Surgical Treatment in a Single Institution. ⁶²	Kim SJ...Kim ML	35512747	2022
38	Identification of Key Differentially Methylated/Expressed Genes and Pathways for Ovarian Endometriosis by Bioinformatics Analysis. ⁶²	Zhang H...Kang S	34671938	2022
39	Hypermethylation of the GRHL2 promoter region is associated with ovarian endometriosis. ⁶²	Hao Y...Kang S	35356893	2022
40	New Understanding of Diagnosis, Treatment and Prevention of Endometriosis. ⁶²	Amro B...Koninckx PR	35682310	2022
41	A Systematic Review of Atypical Endometriosis-Associated Biomarkers. ⁶²	Bartiromo L...Candiani M	35457244	2022
42	Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian endometriosis. ⁶²	Zhang M...Huang F	35368023	2022
43	Comprehensive characterization of endometriosis patients and disease patterns in a large clinical cohort. ⁶²	Blum S...Hein A	34448039	2022
44	Impaired Expression of Membrane Type-2 and Type-3 Matrix Metalloproteinases in Endometriosis but Not in Adenomyosis. ⁶²	Maoga JB...Konrad L	35453827	2022
45	Accuracy of sonography for non-invasive detection of ovarian and deep endometriosis using #Enzian classification: prospective multicenter diagnostic accuracy study. ⁶²	Montanari E...Hudelist G	34919760	2022
46	The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence. ⁶²	Sun SG...Qiu JJ	34893848	2022
47	Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis. ⁶²	Murakami M...Kajiyama H	35351143	2022
48	CSF-1-induced DC-SIGN+ macrophages are present in the ovarian endometriosis. ⁶²	Xiaocui L...Min A	35260161	2022
49	[Expression and significance of GLI1 and Shh in the malignant transformation of ovarian endometriosis]. ⁶²	Zhao F...Wang LM	35184473	2022
50	Platelet-to-Lymphocyte Ratio and CA125 Level as a Combined Biomarker for Diagnosing Endometriosis and Predicting Pelvic Adhesion Severity. ⁶²	Guo C...Zhang C	35800055	2022

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Genes for Endometriosis of Ovary

Genes related to Endometriosis of Ovary (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR141	MicroRNA 141	RNA Gene	10.1	DISEASES inferred ¹⁴ ¹⁴
2	MIR9-1	MicroRNA 9-1	RNA Gene	8.37	DISEASES inferred ¹⁴ ¹⁴
3	MIR145	MicroRNA 145	RNA Gene	7.39	DISEASES inferred ¹⁴ ¹⁴
4	MIR199A1	MicroRNA 199a-1	RNA Gene	7.15	DISEASES inferred ¹⁴ ¹⁴
5	MIR449B	MicroRNA 449b	RNA Gene	7.03	DISEASES inferred ¹⁴ ¹⁴
6	MIR424	MicroRNA 424	RNA Gene	6.67	DISEASES inferred ¹⁴ ¹⁴
7	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	6.67	DISEASES inferred ¹⁴
8	AMH	Anti-Mullerian Hormone	Protein Coding	6.51	DISEASES inferred ¹⁴
9	MIR221	MicroRNA 221	RNA Gene	6.16	DISEASES inferred ¹⁴ ¹⁴
10	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	6.15	DISEASES inferred ¹⁴
11	ESR1	Estrogen Receptor 1	Protein Coding	6.15	DISEASES inferred ¹⁴
12	CHL1-AS1	CHL1 Antisense RNA 1	RNA Gene	6.14	DISEASES inferred ¹⁴
13	MIR510	MicroRNA 510	RNA Gene	6.13	DISEASES inferred ¹⁴ ¹⁴
14	ESR2	Estrogen Receptor 2	Protein Coding	6.08	DISEASES inferred ¹⁴
15	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	6.04	DISEASES inferred ¹⁴
16	UBOX5-AS1	UBOX5 Antisense RNA 1	RNA Gene	6.01	DISEASES inferred ¹⁴
17	CHL1-AS2	CHL1 Antisense RNA 2	RNA Gene	5.97	DISEASES inferred ¹⁴
18	PGR	Progesterone Receptor	Protein Coding	5.89	DISEASES inferred ¹⁴
19	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5.84	DISEASES inferred ¹⁴
20	TTTY8	Testis-Specific Transcript, Y-Linked 8	RNA Gene	5.83	DISEASES inferred ¹⁴
21	MIR139	MicroRNA 139	RNA Gene	5.83	DISEASES inferred ¹⁴ ¹⁴
22	HSD17B2	Hydroxysteroid 17-Beta Dehydrogenase 2	Protein Coding	5.8	DISEASES inferred ¹⁴
23	TTTY22	Testis-Specific Transcript, Y-Linked 22	RNA Gene	5.74	DISEASES inferred ¹⁴
24	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	5.71	DISEASES inferred ¹⁴
25	PTEN	Phosphatase And Tensin Homolog	Protein Coding	5.71	DISEASES inferred ¹⁴
26	TTTY11	Testis-Specific Transcript, Y-Linked 11	RNA Gene	5.66	DISEASES inferred ¹⁴
27	HNF1B	HNF1 Homeobox B	Protein Coding	5.65	DISEASES inferred ¹⁴

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Variations for Endometriosis of Ovary

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Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

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Pathways for Endometriosis of Ovary

Pathways related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.21	PIK3CA PGR ESR2 ESR1
2	Nuclear receptors ⁷⁴ Show member pathways Nuclear Receptor transcription pathway ⁶⁶ SUMOylation of intracellular receptors ⁶⁶	11.78	PGR ESR2 ESR1
3	Validated nuclear estrogen receptor alpha network ⁶¹	11.42	PGR ESR2 ESR1
4	miRNAs involvement in the immune response in sepsis ⁷⁴	11.37	MIR145 MIR199A1 MIR9-1
5	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.35	MIR9-1 MIR221 MIR199A1 MIR145
6	Ovarian infertility ⁷⁴	11.1	PGR ESR2 CYP19A1
7	miRNAs involved in DNA damage response ⁷⁴	11.08	MIR449B MIR424 MIR221 MIR145
8	Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) ⁷⁴	11	PGR ESR2 ESR1
9	Cellular roles of Anthrax toxin ⁶¹	10.82	PGR ESR1
10	Plasma membrane estrogen receptor signaling ⁶¹	10.81	PIK3CA ESR2 ESR1
11	Nongenotropic Androgen signaling ⁶¹	10.77	PIK3CA GNRH1
12	Mammary gland development pathway - Puberty (Stage 2 of 4) ⁷⁴	10.61	PGR ESR1
13	Relationship between inflammation, COX-2 and EGFR ⁷⁴	10.46	PIK3CA CYP19A1
14	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics ⁶⁰	9.4	ESR2 ESR1 CYP19A1

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GO Terms for Endometriosis of Ovary

Cellular components related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RISC complex	GO:0016442	9.4	MIR9-1 MIR424 MIR221 MIR199A1 MIR145 MIR141

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	10.01	PIK3CA PGR MIR9-1 MIR199A1 ESR1
2	miRNA-mediated gene silencing	GO:0035195	9.97	MIR141 MIR145 MIR199A1 MIR221 MIR424 MIR449B
3	negative regulation of inflammatory response	GO:0050728	9.67	MIR221 MIR199A1 MIR145 MIR141
4	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.61	MIR9-1 MIR221 MIR145
5	negative regulation of cell migration involved in sprouting angiogenesis	GO:0090051	9.43	MIR424 MIR221 MIR199A1
6	intracellular estrogen receptor signaling pathway	GO:0030520	9.43	ESR2 ESR1 ARID1A
7	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.32	MIR221 MIR141
8	intracellular steroid hormone receptor signaling pathway	GO:0030518	9.1	PGR ESR2 ESR1

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear receptor activity	GO:0004879	9.88	PGR ESR2 ESR1
2	steroid binding	GO:0005496	9.8	PGR ESR2 ESR1
3	estrogen response element binding	GO:0034056	9.67	ESR2 ESR1
4	nuclear estrogen receptor activity	GO:0030284	9.56	ESR2 ESR1
5	nuclear steroid receptor activity	GO:0003707	9.55	PGR ESR2 ESR1
6	mRNA 3'-UTR binding	GO:0003730	9.35	MIR9-1 MIR424 MIR199A1 MIR145 MIR141
7	mRNA base-pairing translational repressor activity	GO:1903231	9.1	MIR9-1 MIR424 MIR221 MIR199A1 MIR145 MIR141

Sources

Sources for Endometriosis of Ovary

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: END011 MIFTS: 43	Endometriosis of Ovary Categories: Endocrine diseases, Reproductive diseases	Data Licensing For inquiries, contact: [email protected]
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