MCID: END011
MIFTS: 43

Endometriosis of Ovary

Categories: Endocrine diseases, Reproductive diseases
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Aliases & Classifications for Endometriosis of Ovary

MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 11 14 71 75 31
Ovarian Endometriosis 11 16

Classifications:



External Ids:

Disease Ontology 11 DOID:11432
ICD9CM 34 617.1
NCIt 49 C27628
SNOMED-CT 68 198250000
ICD10 31 N80.1
UMLS 71 C0156344

Summaries for Endometriosis of Ovary

Disease Ontology: 11 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary: Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and ovarian cyst. An important gene associated with Endometriosis of Ovary is MIR141 (MicroRNA 141), and among its related pathways/superpathways are Breast cancer pathway and Nuclear receptors. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial, and related phenotypes are neoplasm and no phenotypic analysis

Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)
# Related Disease Score Top Affiliating Genes
1 endometriosis 31.3 PGR MIR424 MIR199A1 MIR145 MIR141 GNRH1
2 ovarian cyst 30.7 PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
3 infertility 30.6 PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
4 leiomyoma 30.5 PGR GNRH1 ESR2 ESR1 CYP19A1
5 progesterone resistance 30.5 PGR ESR2 ESR1
6 ovarian clear cell carcinoma 30.4 PIK3CA MIR9-1 MIR424 MIR221 MIR199A1 ARID1A
7 serous cystadenocarcinoma 30.4 PIK3CA PGR MIR199A1 ESR1 ARID1A
8 leiomyomatosis 30.4 PGR GNRH1 ESR1
9 papillary serous adenocarcinoma 30.4 PGR MIR145 ESR1
10 leiomyoma, uterine 30.3 PGR GNRH1 ESR2 ESR1 CYP19A1
11 myoma 30.3 PGR GNRH1 ESR1 CYP19A1 AMH
12 cystadenocarcinoma 30.2 PGR MIR199A1 ESR2 ARID1A
13 clear cell adenofibroma 30.2 PIK3CA ARID1A
14 diffuse peritoneal leiomyomatosis 30.2 PGR GNRH1 ESR1 CYP19A1
15 endometrial stromal sarcoma 30.1 PGR ESR2 ESR1 CYP19A1
16 pseudohermaphroditism 30.1 GNRH1 CYP19A1 AMH
17 endometrial adenocarcinoma 30.1 PGR MIR199A1 ESR1
18 hyperandrogenism 30.1 GNRH1 CYP19A1 AMH
19 endometrial cancer 30.1 PIK3CA PGR MIR199A1 MIR145 MIR141 GNRH1
20 premature menopause 30.0 PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
21 colonic benign neoplasm 30.0 PIK3CA MIR199A1 MIR145 ESR1
22 adenomyoma 30.0 PGR GNRH1 ESR1 AMH
23 intestinal disease 29.9 MIR9-1 MIR424 MIR221 MIR199A1 MIR145 MIR141
24 ovary adenocarcinoma 29.9 PIK3CA PGR ESR1 ARID1A
25 ovarian cancer 29.8 PIK3CA PGR MIR9-1 MIR424 MIR221 MIR199A1
26 endometrial hyperplasia 29.8 PGR ESR2 ESR1 CYP19A1 ARID1A
27 male infertility 29.6 MIR510 GNRH1 ESR2 ESR1 CYP19A1 AMH
28 estrogen excess 29.6 PGR GNRH1 ESR2 ESR1 CYP19A1 AMH
29 ovarian disease 29.3 PGR MIR9-1 MIR424 MIR221 MIR199A1 MIR145
30 epithelial-myoepithelial carcinoma 10.4
31 adenomyosis 10.4
32 cervix small cell carcinoma 10.4 MIR199A1 MIR145
33 rectum carcinoma in situ 10.4 ESR2 ESR1
34 nonmucinous bronchioloalveolar adenocarcinoma 10.4 ESR2 ESR1
35 ovarian serous carcinoma 10.3 MIR199A1 MIR145 MIR141
36 nipple carcinoma 10.3 PGR ESR1
37 bartholin's gland adenoma 10.3 PGR ESR1
38 uterine corpus adenosarcoma 10.3 PGR ESR1
39 breast mucinous cystadenocarcinoma 10.3 PGR ESR1
40 bartholin's gland benign neoplasm 10.3 PGR ESR1
41 breast fibroadenosis 10.3 PGR ESR1
42 vestibular gland benign neoplasm 10.3 PGR ESR1
43 uterine sarcoma 10.3 ESR1 CYP19A1
44 lung leiomyoma 10.3 PGR MIR221
45 bulbospinal polio 10.3 PGR ESR1
46 spinal polio 10.3 PGR ESR1
47 glycogen-rich clear cell breast carcinoma 10.3 PGR ESR1
48 adult cystic nephroma 10.3 PGR ESR1
49 breast cystic hypersecretory carcinoma 10.3 PGR ESR1
50 vagina leiomyosarcoma 10.3 PGR ESR1

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Adenomyosis Fallopian Tube Endometriosis
Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary

Symptoms & Phenotypes for Endometriosis of Ovary

MGI Mouse Phenotypes related to Endometriosis of Ovary:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.5 AMH ARID1A ESR1 ESR2 GNRH1 PGR
2 no phenotypic analysis MP:0003012 9.28 AMH ARID1A ESR1 ESR2 MIR199A1 MIR424

Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 5311128 47725
3 Antineoplastic Agents, Hormonal Phase 4
4 Estrogens Phase 4
5 Estrogen Receptor Antagonists Phase 4
6 Estrogen Antagonists Phase 4
7 Hormones Phase 4
8 Hormone Antagonists Phase 4
9 Aromatase Inhibitors Phase 4
10
Medroxyprogesterone acetate Approved, Investigational Phase 2 520-85-4, 71-58-9 6279 10631

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 A Phase IIa Efficacy and Safety Study of PGL5001 Versus Placebo Administered for up to 5 Months With Concomitant Administration of Depot Medroxyprogesterone Acetate for the Treatment of Peritoneal and/or Ovarian Endometriosis With an Inflammatory Component. Completed NCT01630252 Phase 2 PGL5001;Placebo
3 Methylation of cfDNA in Diagnosis and Differential Diagnosis of Ovarian Endometriosis Unknown status NCT04220710
4 Evaluating Ovarian Reserve After Conventional Laparoscopy Versus Robotic Surgery for Bilateral Endometrioma: a Randomized Controlled Trial. Recruiting NCT05357924

Search NIH Clinical Center for Endometriosis of Ovary

Genetic Tests for Endometriosis of Ovary

Anatomical Context for Endometriosis of Ovary

Organs/tissues related to Endometriosis of Ovary:

FMA: Ovary
MalaCards : Ovary, Uterus, Endothelial, T Cells, Cervix, Appendix, Lymph Node

Publications for Endometriosis of Ovary

Articles related to Endometriosis of Ovary:

(show top 50) (show all 941)
# Title Authors PMID Year
1
Influence of endometrioma size on ART outcomes. 62
36167632 2022
2
Three-Dimensional Ultrasound Evaluation of Pelvic Floor Muscle Contraction in Women Affected by Deep Infiltrating Endometriosis: Application of a Quick Contraction Scale. 62
35532292 2022
3
Extremely high serum CA19-9 level along with elevated D-dimer in assisting detection of ruptured ovarian endometriosis. 62
35733415 2022
4
Knockdown of miR-150-5p reduces hypoxia-induced autophagy and epithelial-mesenchymal transition of endometriotic cells via regulating the PDCD4/NF-κB signaling pathway. 62
36427469 2022
5
Effect of PLGA Nanoparticle-Mediated Delivery of miRNA 503 on The Apoptosis of Ovarian Endometriosis Cells. 62
36377220 2022
6
Elevated phosphorylation of estrogen receptor α at serine-118 in ovarian endometrioma. 62
35654737 2022
7
Claudin-10 Expression Is Increased in Endometriosis and Adenomyosis and Mislocalized in Ectopic Endometriosis. 62
36428908 2022
8
Distinct clinicopathological features of ovarian endometriosis after long-term exposure to mifepristone. 62
36348508 2022
9
Pelvic floor dysfunction at transperineal ultrasound and chronic constipation in women with endometriosis. 62
34995357 2022
10
Surgically confirmed endometriosis in adolescents in Finland-A register-based cross-sectional cohort study. 62
35818936 2022
11
The comparison of two different protocols ultra-long versus medroxyprogesterone acetate in women with ovarian endometriosis: a prospective randomized controlled trial. 62
36195878 2022
12
Integrated bioinformatic analysis of dysregulated microRNA-mRNA co-expression network in ovarian endometriosis. 62
35876135 2022
13
Effect of the mode of delivery on the risk of endometriosis recurrence: a retrospective cohort study. 62
36243596 2022
14
Low-Nutrient Environment-Induced Changes in Inflammation, Cell Proliferation, and PGC-1α Expression in Stromal Cells with Ovarian Endometriosis. 62
36197633 2022
15
Cyclic hematochezia in young woman with appendiceal endometriosis. 62
36263823 2022
16
Clinical characteristics and surgical management of endometriosis-associated infertility: A multicenter prospective cohort study. 62
35075631 2022
17
mRNA, lncRNA and Circular RNA Expression Profiles in Granulosa Cells of Infertile Women with Ovarian Endometriosis. 62
35799021 2022
18
FOR: Fertility preservation for women with ovarian endometriosis: It is time to adopt it as routine practice. 62
35434942 2022
19
Effects of EZH2 on Invasion and Migration of Endometrial Stromal Cells in Endometriosis Patients by Regulating PCDH10 Gene H3K27 Methylation. 62
36239569 2022
20
Endometriosis: Cellular and Molecular Mechanisms Leading to Fibrosis. 62
36289173 2022
21
Serum anti-Müllerian hormone recovery after ovarian cystectomy for endometriosis: A retrospective study among Korean women. 62
36221377 2022
22
Down-regulation of HLA-DRs and HLA-DPs reflects the deficiency of antigen-presenting cells in endometrium from infertile women with and without ovarian endometriosis. 62
33787425 2022
23
AGAINST: Fertility preservation for women with ovarian endometriosis: it is time to adopt this as routine practice. 62
35614636 2022
24
Pregnancy following robot-assisted laparoscopic bilateral endometriotic cystectomy rare case report of endometriosis stage IV. 62
35985118 2022
25
Novel missense variant of CIITA contributing to endometriosis. 62
35835655 2022
26
IGF2BP2 promotes the progression of ovarian endometriosis by regulating m6A-modified MEIS2 and GATA6. 62
36113831 2022
27
Potential clinical implications of iron metabolism in ovarian endometriosis. 62
35763972 2022
28
Mixed Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) of the Ovary Arising from Endometriosis: Molecular Pathology Analysis in Support of a Pathogenetic Paradigm. 62
34342838 2022
29
Ovarian clear cell carcinoma arising in a large endometrioma - A case report with pathological correlation and literature review. 62
35694637 2022
30
Whole-exome sequencing and functional validation reveal a rare missense variant in MMP7 that confers ovarian endometriosis risk. 62
35288736 2022
31
Unbiased In Silico Analysis of Gene Expression Pinpoints Circulating miRNAs Targeting KIAA1324, a New Gene Drastically Downregulated in Ovarian Endometriosis. 62
36140165 2022
32
The presence of living endometrial cells in ovarian endometriotic cyst fluid may contribute to the recurrence of endometriosis after surgical excision of endometriomas. 62
35907907 2022
33
Effects of metformin, letrozole and atorvastatin on inflammation and apoptosis in experimental peritoneal and ovarian endometriosis in the rat. 62
35644046 2022
34
Sonographic features differentiating early-stage ovarian clear cell carcinoma from endometrioma with atypical features. 62
35836288 2022
35
CCL20/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis. 62
35841069 2022
36
Endometriosis is associated with a lowered cumulative live birth rate: A retrospective matched cohort study including 3071 in vitro fertilization cycles. 62
35504114 2022
37
Cumulative Recurrence Rate and Risk Factors for Recurrent Abdominal Wall Endometriosis after Surgical Treatment in a Single Institution. 62
35512747 2022
38
Identification of Key Differentially Methylated/Expressed Genes and Pathways for Ovarian Endometriosis by Bioinformatics Analysis. 62
34671938 2022
39
Hypermethylation of the GRHL2 promoter region is associated with ovarian endometriosis. 62
35356893 2022
40
New Understanding of Diagnosis, Treatment and Prevention of Endometriosis. 62
35682310 2022
41
A Systematic Review of Atypical Endometriosis-Associated Biomarkers. 62
35457244 2022
42
Endometrial epithelial cells-derived exosomes deliver microRNA-30c to block the BCL9/Wnt/CD44 signaling and inhibit cell invasion and migration in ovarian endometriosis. 62
35368023 2022
43
Comprehensive characterization of endometriosis patients and disease patterns in a large clinical cohort. 62
34448039 2022
44
Impaired Expression of Membrane Type-2 and Type-3 Matrix Metalloproteinases in Endometriosis but Not in Adenomyosis. 62
35453827 2022
45
Accuracy of sonography for non-invasive detection of ovarian and deep endometriosis using #Enzian classification: prospective multicenter diagnostic accuracy study. 62
34919760 2022
46
The extracellular vesicular pseudogene LGMNP1 induces M2-like macrophage polarization by upregulating LGMN and serves as a novel promising predictive biomarker for ovarian endometriosis recurrence. 62
34893848 2022
47
Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis. 62
35351143 2022
48
CSF-1-induced DC-SIGN+ macrophages are present in the ovarian endometriosis. 62
35260161 2022
49
[Expression and significance of GLI1 and Shh in the malignant transformation of ovarian endometriosis]. 62
35184473 2022
50
Platelet-to-Lymphocyte Ratio and CA125 Level as a Combined Biomarker for Diagnosing Endometriosis and Predicting Pelvic Adhesion Severity. 62
35800055 2022

Variations for Endometriosis of Ovary

Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

Pathways for Endometriosis of Ovary

GO Terms for Endometriosis of Ovary

Cellular components related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.4 MIR9-1 MIR424 MIR221 MIR199A1 MIR145 MIR141

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 10.01 PIK3CA PGR MIR9-1 MIR199A1 ESR1
2 miRNA-mediated gene silencing GO:0035195 9.97 MIR141 MIR145 MIR199A1 MIR221 MIR424 MIR449B
3 negative regulation of inflammatory response GO:0050728 9.67 MIR221 MIR199A1 MIR145 MIR141
4 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.61 MIR9-1 MIR221 MIR145
5 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.43 MIR424 MIR221 MIR199A1
6 intracellular estrogen receptor signaling pathway GO:0030520 9.43 ESR2 ESR1 ARID1A
7 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.32 MIR221 MIR141
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.1 PGR ESR2 ESR1

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear receptor activity GO:0004879 9.88 PGR ESR2 ESR1
2 steroid binding GO:0005496 9.8 PGR ESR2 ESR1
3 estrogen response element binding GO:0034056 9.67 ESR2 ESR1
4 nuclear estrogen receptor activity GO:0030284 9.56 ESR2 ESR1
5 nuclear steroid receptor activity GO:0003707 9.55 PGR ESR2 ESR1
6 mRNA 3'-UTR binding GO:0003730 9.35 MIR9-1 MIR424 MIR199A1 MIR145 MIR141
7 mRNA base-pairing translational repressor activity GO:1903231 9.1 MIR9-1 MIR424 MIR221 MIR199A1 MIR145 MIR141

Sources for Endometriosis of Ovary

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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