MCID: END011
MIFTS: 41

Endometriosis of Ovary

Categories: Endocrine diseases, Reproductive diseases

Aliases & Classifications for Endometriosis of Ovary

MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 74
Ovarian Endometriosis 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:11432
ICD9CM 36 617.1
NCIt 51 C27628
SNOMED-CT 69 31007005
ICD10 34 N80.1
UMLS 74 C0156344

Summaries for Endometriosis of Ovary

Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to ovarian clear cell carcinoma and ovary adenocarcinoma. An important gene associated with Endometriosis of Ovary is ESR2 (Estrogen Receptor 2), and among its related pathways/superpathways are Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR2 and Plasma membrane estrogen receptor signaling. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial.

Wikipedia : 77 Endometrioma is the presence of endometrial tissue in and sometimes on the ovary. It is the most common... more...

Related Diseases for Endometriosis of Ovary

Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell carcinoma 30.1 ARID1A HNF1B
2 ovary adenocarcinoma 29.9 ARID1A HNF1B
3 ovarian cancer 1 29.9 ARID1A HNF1B
4 endometriosis 11.0
5 clear cell adenocarcinoma 10.3 ARID1A HNF1B
6 extrapelvic endometriosis 10.3
7 postmenopausal atrophic vaginitis 10.3 ESR1 ESR2
8 vaginitis 10.3 ESR1 ESR2
9 progesterone-receptor positive breast cancer 10.3 ESR1 ESR2
10 progesterone resistance 10.3 ESR1 ESR2
11 gender identity disorder 10.2 ESR1 ESR2
12 estrogen excess 10.2 ESR1 ESR2
13 dental fluorosis 10.2 ESR1 ESR2
14 lobular neoplasia 10.2 ESR1 ESR2
15 ovarian cancer 10.2
16 sarcoma 10.2
17 adenocarcinoma 10.2
18 ovarian clear cell adenocarcinoma 10.2 ARID1A ESR2 HNF1B
19 estrogen resistance 10.1 ESR1 TRERF1
20 female reproductive system disease 10.1 ARID1A ESR1 ESR2
21 malignant ovarian surface epithelial-stromal neoplasm 10.1 ARID1A ESR1 HNF1B
22 ovary epithelial cancer 10.1 ARID1A ESR1 HNF1B
23 squamous cell carcinoma 10.1
24 infertility 10.1
25 hydatidiform mole, recurrent, 1 10.0
26 adenomyosis 10.0
27 ectopic pregnancy 10.0
28 ulceration of vulva 10.0
29 leiomyoma 10.0
30 acromegaly 10.0
31 gestational trophoblastic neoplasm 10.0
32 arthropathy 10.0
33 adenoma 10.0
34 leiomyoma, uterine 9.8
35 joint disorders 9.8
36 persistent mullerian duct syndrome 9.8
37 pelvic inflammatory disease 9.8
38 ovarian disease 9.8
39 adenofibroma 9.8
40 endometrial adenocarcinoma 9.8
41 cystadenocarcinoma 9.8
42 serous cystadenocarcinoma 9.8
43 teratoma 9.8
44 endometrial stromal sarcoma 9.8
45 spindle cell sarcoma 9.8
46 carcinosarcoma 9.8
47 leiomyomatosis 9.8
48 intestinal disease 9.8
49 clear cell adenofibroma 9.8
50 ovarian germ cell teratoma 9.8

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Fallopian Tube Endometriosis Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary

Symptoms & Phenotypes for Endometriosis of Ovary

Drugs & Therapeutics for Endometriosis of Ovary

Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 5311128 47725
3 Aromatase Inhibitors Phase 4
4 Estrogen Receptor Antagonists Phase 4
5 Estrogen Antagonists Phase 4
6 Hormones Phase 4,Not Applicable
7 Steroid Synthesis Inhibitors Phase 4
8 Antineoplastic Agents, Hormonal Phase 4,Phase 2
9 Hormone Antagonists Phase 4,Not Applicable
10 Estrogens Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
12
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
13
Axitinib Approved, Investigational Phase 1, Phase 2 319460-85-0 6450551
14
afatinib Approved Phase 1, Phase 2 850140-72-6, 439081-18-2 10184653
15
Medroxyprogesterone Phase 2 520-85-4 10631
16 Contraceptive Agents Phase 2
17 Contraceptive Agents, Male Phase 2
18 Protein Kinase Inhibitors Phase 1, Phase 2
19
Pentetic acid Approved Not Applicable 67-43-6
20
Edetic Acid Approved, Vet_approved Not Applicable 62-33-9, 60-00-4 6049
21 Anesthetics Not Applicable
22 Coagulants Not Applicable
23 Hemostatics Not Applicable
24 Follicle Stimulating Hormone Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 PGL5001 Proof of Concept Study in Inflammatory Endometriosis Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 Safety, Tolerability and Efficacy of Vaginal Suppositories for Treatment of the Endometriosis Not yet recruiting NCT03481842 Phase 1, Phase 2 BIBW2992;Axitinib
4 Somatic Stem Cells in Endometriosis Unknown status NCT01412138
5 Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy Completed NCT03826355 Not Applicable
6 Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients Completed NCT02984774 Not Applicable
7 Artificial Reproductive Techniques (ART) and Progression of Endometriosis Symptoms Completed NCT02762461
8 Perinatal Consequences of Endometriosis Active, not recruiting NCT02498691 Not Applicable
9 Oxidative Stress Gene Polymorphism and Ovarian Reserve Functione Not yet recruiting NCT03682341
10 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma Not yet recruiting NCT03430609 Not Applicable

Search NIH Clinical Center for Endometriosis of Ovary

Genetic Tests for Endometriosis of Ovary

Anatomical Context for Endometriosis of Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

42
Ovary, Uterus, Endothelial, Liver, Cervix, Smooth Muscle, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Endometriosis of Ovary:

20
The Ovary

Publications for Endometriosis of Ovary

Articles related to Endometriosis of Ovary:

(show top 50) (show all 249)
# Title Authors Year
1
Aberrant methylation of the IL-12B promotor region contributes to the risk of developing ovarian endometriosis. ( 30865360 )
2019
2
Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis. ( 30882467 )
2019
3
Extra-uterine low grade endometrioid stromal sarcoma arising from ovarian endometriosis: a case report and review of the literature. ( 30723546 )
2019
4
Metabolomics analysis of follicular fluid in women with ovarian endometriosis undergoing in vitro fertilization. ( 29806498 )
2019
5
Vibrational characterization of granulosa cells from patients affected by unilateral ovarian endometriosis: New insights from infrared and Raman microspectroscopy. ( 30639914 )
2019
6
Analysis of long non-coding RNA expression profiles using RNA sequencing in ovarian endometriosis. ( 29920364 )
2018
7
Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis. ( 29928437 )
2018
8
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis. ( 29669342 )
2018
9
Ovarian endometriosis: risk factor analysis and prediction of malignant transformation. ( 29725285 )
2018
10
A functional promoter polymorphism in interleukin 12B gene is associated with an increased risk of ovarian endometriosis. ( 29738836 )
2018
11
Integration analysis of microRNA and mRNA paired expression profiling identifies deregulated microRNA-transcription factor-gene regulatory networks in ovarian endometriosis. ( 29357938 )
2018
12
Novel TRERF1 mutations in Chinese patients with ovarian endometriosis. ( 29393434 )
2018
13
Factors that Differentiate between Endometriosis-associated Ovarian Cancer and Benign Ovarian Endometriosis with Mural Nodules. ( 28824051 )
2018
14
Pelvic floor muscle assessment on three- and four-dimensional transperineal ultrasound in women with ovarian endometriosis with or without retroperitoneal infiltration: a step towards complete functional assessment. ( 29024196 )
2018
15
Circular RNA expression in ovarian endometriosis. ( 29334789 )
2018
16
Immunohistochemical Features of O6-Methylguanine-DNA Methyltransferase Expression during Ovarian Endometriosis. ( 29308563 )
2018
17
Decreased Expression of HOXA10 May Activate the Autophagic Process in Ovarian Endometriosis. ( 29658437 )
2018
18
Ovarian endometriosis and fertility preservation: a challenge in 2018. ( 29644329 )
2018
19
EGFR-mediated matrix metalloproteinase-7 up-regulation promotes epithelial-mesenchymal transition via ERK1-AP1 axis during ovarian endometriosis progression. ( 29558202 )
2018
20
Perimenopausal management of ovarian endometriosis and associated cancer risk: When is medical or surgical treatment indicated? ( 29551389 )
2018
21
The presence of KRAS, PPP2R1A and ARID1A mutations in 101 Chinese samples with ovarian endometriosis. ( 29547736 )
2018
22
The Relationship of Circular RNAs With Ovarian Endometriosis. ( 29490568 )
2018
23
Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis. ( 29483390 )
2018
24
Comparison of Outcomes of Different Postoperative Hormone Therapy in the Treatment of Ovarian Endometriosis: A Brief Report. ( 29873006 )
2018
25
Novel CTCF mutations in Chinese patients with ovarian endometriosis. ( 29845264 )
2018
26
G protein‑coupled estrogen receptor/miR‑148a/human leukocyte antigen‑G signaling pathway mediates cell apoptosis of ovarian endometriosis. ( 29845209 )
2018
27
Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over. ( 29786043 )
2018
28
Peptidomic Analysis of Endometrial Tissue from Patients with Ovarian Endometriosis. ( 29763921 )
2018
29
Mutation analysis of ZP1, ZP2, ZP3 and ZP4 genes in 152 Han Chinese samples with ovarian endometriosis. ( 30611916 )
2018
30
Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics. ( 30566420 )
2018
31
Ovarian endometriosis and infertility: in vitro fertilization (IVF) or surgery as the first approach? ( 30503109 )
2018
32
Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma. ( 28930811 )
2017
33
Use of medroxyprogesterone acetate in women with ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization. ( 28931865 )
2017
34
Silencing of SRA1 Regulates ER Expression and Attenuates the Growth of Stromal Cells in Ovarian Endometriosis. ( 27694140 )
2017
35
Endometrioid adenocarcinoma originating simultaneously from endometrium, sites of adenomyosis and ovarian endometriosis: A case report and review of our cancer database. ( 29096350 )
2017
36
A case of spontaneous abortion related to ovarian endometriosis in a Golden Retriever dog. ( 28588636 )
2017
37
Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis. ( 27928852 )
2017
38
Ten Principles for Safe Surgical Treatment of Ovarian Endometriosis. ( 27932268 )
2017
39
Ovarian endometriosis and vitamin D serum levels. ( 27809683 )
2017
40
Association of Endometriosis-Associated Genetic Polymorphisms From Genome-Wide Association Studies With Ovarian Endometriosis in a Chinese Population. ( 27233752 )
2017
41
Aberrant Methylation of the E-Cadherin Gene Promoter Region in Endometrium and Ovarian Endometriotic Cysts of Patients with Ovarian Endometriosis. ( 27023436 )
2017
42
Ovarian endometriosis during pregnancy: a series of 53 endometriomas. ( 26482730 )
2017
43
Diagnostic performance of human epididymis protein 4 compared to a combination of biophysical and biochemical markers to differentiate ovarian endometriosis from epithelial ovarian cancer in premenopausal women. ( 29027715 )
2017
44
Transverse Relaxation Rate of Cyst Fluid Can Predict Malignant Transformation of Ovarian Endometriosis. ( 27646154 )
2016
45
EP27.12: EndometriomaA -A the tip of a pelvic disease: TVS findings associated with an ovarian endometriosis. ( 27647664 )
2016
46
The co-expression of GPER and Gankyrin in ovarian endometriosis and its correlation with the rASRM stages. ( 26193952 )
2016
47
Increased Expression of Interleukin 37 in the Eutopic and Ectopic Endometrium of Patients With Ovarian Endometriosis. ( 26342048 )
2016
48
Persistent Mullerian Duct Syndrome with Ovarian Endometriosis-A Rare Case Report. ( 27042476 )
2016
49
Bilateral Ovarian Clear Cell Carcinoma Arising in 17 Year Longstanding History of Bilateral Ovarian Endometriosis. ( 28974971 )
2016
50
Differential studies of ovarian endometriosis cells from endometrium or oviduct. ( 27424973 )
2016

Variations for Endometriosis of Ovary

Expression for Endometriosis of Ovary

Search GEO for disease gene expression data for Endometriosis of Ovary.

Pathways for Endometriosis of Ovary

Pathways related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.7 ESR1 ESR2
2 10.57 ESR1 ESR2
3 10.32 ESR1 ESR2
4 9.23 ESR1 ESR2

GO Terms for Endometriosis of Ovary

Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.35 ARID1A ESR1 ESR2 HNF1B TRERF1
2 regulation of Wnt signaling pathway GO:0030111 9.16 ESR1 HNF1B
3 intracellular estrogen receptor signaling pathway GO:0030520 8.8 ARID1A ESR1 ESR2

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.32 ESR1 ESR2
2 nuclear receptor activity GO:0004879 9.26 ESR1 ESR2
3 steroid binding GO:0005496 9.16 ESR1 ESR2
4 estrogen receptor activity GO:0030284 8.96 ESR1 ESR2
5 estrogen response element binding GO:0034056 8.62 ESR1 ESR2

Sources for Endometriosis of Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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