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MCID: END011
MIFTS: 39

Endometriosis of Ovary

Categories: Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endometriosis of Ovary

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MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 71 32
Ovarian Endometriosis 12 17

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11432
ICD9CM 34 617.1
NCIt 50 C27628
SNOMED-CT 67 198250000
ICD10 32 N80.1
UMLS 71 C0156344
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Summaries for Endometriosis of Ovary

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Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and ovarian cyst. An important gene associated with Endometriosis of Ovary is MIR141 (MicroRNA 141), and among its related pathways/superpathways are MicroRNAs in cancer and MNAR-PELP1 and Estrogen Receptor Interaction. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and endothelial.

Wikipedia : 74 Endometrioma is the presence of endometrial tissue in and sometimes on the ovary. It is the most common... more...

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Related Diseases for Endometriosis of Ovary

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Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 endometriosis 31.2 MIR145 MIR141 GNRH1 ESR2 ESR1 CYP19A1
2 ovarian cyst 30.9 MIR145 GNRH1 CYP19A1
3 leiomyoma, uterine 30.3 GNRH1 ESR1 CYP19A1
4 adenomyosis 30.3 GNRH1 ESR2 ESR1 CYP19A1
5 leiomyoma 30.2 GNRH1 ESR2 ESR1 CYP19A1
6 progesterone resistance 30.2 HSD17B2 ESR2 ESR1
7 myoma 30.1 GNRH1 ESR1 CYP19A1 AMH
8 intestinal disease 30.0 MIR9-1 MIR30E MIR145 MIR141
9 endometrial hyperplasia 29.8 ESR2 ESR1 CYP19A1 ARID1A
10 endometrial cancer 29.7 MIR145 GNRH1 ESR2 ESR1 CYP19A1 ARID1A
11 estrogen excess 29.6 GNRH1 ESR2 ESR1 CYP19A1
12 premature menopause 29.6 GNRH1 ESR2 ESR1 CYP19A1 AMH
13 endometrial stromal sarcoma 29.5 ESR2 ESR1 CYP19A1
14 ovarian disease 29.3 MIR9-1 MIR145 MIR141 GNRH1 ESR2 ESR1
15 ovarian cancer 29.3 MIR9-1 MIR30E MIR145 MIR141 GNRH1 ESR2
16 infertility 10.5
17 subserous uterine fibroid 10.3 CYP19A1 AMH
18 bile duct adenocarcinoma 10.3 MIR9-1 MIR30E MIR145
19 nonmucinous bronchioloalveolar adenocarcinoma 10.3 ESR2 ESR1
20 ovarian clear cell carcinoma 10.3
21 mammographic density 10.3 ESR1 CYP19A1
22 bile duct disease 10.3 MIR9-1 MIR30E MIR145
23 biliary tract disease 10.2 MIR9-1 MIR30E MIR145
24 bile duct cystadenoma 10.2 ESR2 ESR1
25 bone marrow cancer 10.2 MIR9-1 MIR30E MIR145
26 pharynx cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
27 lymphatic system cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
28 arteries, anomalies of 10.2 MIR9-1 MIR30E MIR145 MIR141
29 ovarian epithelial cancer 10.2
30 pancreas disease 10.2 MIR9-1 MIR30E MIR145 MIR141
31 lymphatic system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
32 male reproductive organ cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
33 immune system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
34 nasopharyngeal disease 10.2 MIR9-1 MIR30E MIR141
35 transsexualism 10.2 ESR2 CYP19A1
36 male reproductive system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
37 reproductive system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
38 vaginal adenoma 10.2 ESR2 CYP19A1
39 urinary system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
40 vaginal benign neoplasm 10.2 ESR2 CYP19A1
41 large intestine cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
42 female reproductive system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
43 diffuse peritoneal leiomyomatosis 10.2 GNRH1 CYP19A1
44 endocrine gland cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
45 respiratory system cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
46 endocrine system disease 10.2 MIR9-1 MIR30E MIR145 MIR141
47 gastrointestinal system cancer 10.2 MIR9-1 MIR30E MIR145 MIR141
48 adenocarcinoma 10.2
49 sarcoma 10.2
50 spindle cell sarcoma 10.2

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Fallopian Tube Endometriosis Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary
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Symptoms & Phenotypes for Endometriosis of Ovary

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Drugs & Therapeutics for Endometriosis of Ovary

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Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5 47725 5311128
3 Hormone Antagonists Phase 4
4 Estrogen Receptor Antagonists Phase 4
5 Estrogens Phase 4
6 Estrogen Antagonists Phase 4
7 Hormones Phase 4
8 Aromatase Inhibitors Phase 4
9 Antineoplastic Agents, Hormonal Phase 4
10
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
11
Medroxyprogesterone Phase 2 520-85-4 10631

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 A Phase IIa Efficacy and Safety Study of PGL5001 Versus Placebo Administered for up to 5 Months With Concomitant Administration of Depot Medroxyprogesterone Acetate for the Treatment of Peritoneal and/or Ovarian Endometriosis With an Inflammatory Component. Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 "Identification, Characterization and Isolation of Somatic Stem Cells in Human Endometrium of Women With Endometriosis" Unknown status NCT01412138
4 Study of the Relationship Between Oxidative Stress Gene Polymorphism and Individual Variation of Ovarian Reserve Function in Patients With Ovarian Endometrioma Unknown status NCT03682341
5 Methylation of cfDNA in Diagnosis and Differential Diagnosis of Ovarian Endometriosis Recruiting NCT04220710

Search NIH Clinical Center for Endometriosis of Ovary

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Genetic Tests for Endometriosis of Ovary

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Anatomical Context for Endometriosis of Ovary

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The Foundational Model of Anatomy Ontology organs/tissues related to Endometriosis of Ovary:

19
Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

40
Ovary, Uterus, Endothelial, Cervix, T Cells, Colon, Breast
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Publications for Endometriosis of Ovary

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Articles related to Endometriosis of Ovary:

(show top 50) (show all 836)
# Title Authors PMID Year
1
Ovarian endometriosis, a precursor of ovarian cancer: Histological aspects, gene expression and microRNA alterations (Review). 61
33603851 2021
2
RNA sequencing-based long non-coding RNA analysis and immunoassay in ovarian endometriosis. 61
33063885 2021
3
The prognostic role of ovarian endometriosis in symptomatic adenomyosis patients underwent uterine artery embolization. 61
33548995 2021
4
Guidelines for biomarker discovery in endometrium: Correcting for menstrual cycle bias reveals new genes associated with uterine disorders. 61
33576824 2021
5
Endometriosis: A Comprehensive Review. 61
33044230 2021
6
Antral follicle count is reduced in the presence of endometriosis: a systematic review and meta-analysis. 61
33168492 2021
7
Identification of Functional lncRNAs Associated With Ovarian Endometriosis Based on a ceRNA Network. 61
33584822 2021
8
Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages. 61
33543288 2021
9
Endometrial thickness in the evaluation of clinical response to medical treatment for deep infiltrating endometriosis: a retrospective study. 61
32926208 2021
10
Risk factors for the development of tubo-ovarian abscesses in women with ovarian endometriosis: a retrospective matched case-control study. 61
33516203 2021
11
Recurrence Rate and Risk Factors for the Recurrence of Ovarian Endometriosis after Laparoscopic Ovarian Cystectomy. 61
33575338 2021
12
The #Enzian classification: A comprehensive non-invasive and surgical description system for endometriosis. 61
33483970 2021
13
Induction of autophagy by Beclin-1 in granulosa cells contributes to follicular progesterone elevation in ovarian endometriosis. 61
32640290 2021
14
Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study. 61
32964764 2021
15
Application of serum markers in diagnosis and staging of ovarian endometriosis. 61
33448139 2021
16
Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages. 61
33270114 2020
17
Affected Ovary Relative Volume: A Novel Sonographic Predictor of Ovarian Reserve in Patients with Unilateral Endometrioma-A Pilot Study. 61
33348770 2020
18
External validation of putative biomarkers in eutopic endometrium of women with endometriosis using NanoString technology. 61
33033989 2020
19
Establishment of an immortalized stromal cell line derived from human Endometriotic lesion. 61
33225937 2020
20
Coincidence of uterine malformations and endometriosis: a clinically relevant problem? 61
32816056 2020
21
The ultrasound of subcutaneous extrapelvic endometriosis. 61
33365153 2020
22
The levels of follicular fluid cell-free mitochondrial DNA could serve as a biomarker for pregnancy success in patients with small ovarian endometriosis cysts: A case-control study. 61
33235102 2020
23
Clinical characteristics and pregnancy outcomes of infertile patients with endometriosis and endometrial polyps: A retrospective cohort study. 61
33218412 2020
24
Expression of cellular adherent and invasive molecules in recurrent ovarian endometriosis. 61
33249961 2020
25
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice. 61
32961443 2020
26
Decreased Expression of Peroxiredoxin in Patients with Ovarian Endometriosis Cysts. 61
32564961 2020
27
Clinical characteristics difference between early and late recurrence of ovarian endometriosis after laparoscopic cystectomy. 61
32583208 2020
28
Endometrial stromal cell inflammatory phenotype during severe ovarian endometriosis as a cause of endometriosis-associated infertility. 61
32792135 2020
29
Syndecan-1 modulates the invasive potential of endometrioma via TGF-β signalling in a subgroup of women with endometriosis. 61
32897364 2020
30
Increased expression of epithelial cell adhesion molecule and its possible role in epithelial-mesenchymal transition in endometriosis. 61
32715572 2020
31
YAP1 inhibits ovarian endometriosis stromal cell invasion through ESR2. 61
32544876 2020
32
An integration analysis of mRNAs and miRNAs microarray data to identify key regulators for ovarian endometriosis based on competing endogenous RNAs. 61
32738676 2020
33
Elevated expressions of SHP2 and GAB2 correlated with VEGF in eutopic and ectopic endometrium of women with ovarian endometriosis. 61
32619126 2020
34
Identification of MicroRNAs as Potential Biomarkers in Ovarian Endometriosis. 61
32651898 2020
35
Pathology of clear cell carcinoma of the ovary: A basic view based on cultured cells and modern view from comprehensive approaches. 61
32476214 2020
36
Ultrasound findings in infertile women with endometriosis: evidence of concomitant uterine disorders. 61
32133885 2020
37
A novel non-invasive molecular biomarker in ovarian endometriosis: estrogen-related receptor α. 61
32468161 2020
38
Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature. 61
32452019 2020
39
ARID1A protein expression is retained in ovarian endometriosis with ARID1A loss-of-function mutations: implication for the two-hit hypothesis. 61
32868822 2020
40
Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis. 61
32473611 2020
41
IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis. 61
32436195 2020
42
Ezrin T567 phosphorylation regulates migration and invasion of ectopic endometrial stromal cells by changing actin cytoskeleton. 61
32380081 2020
43
The role of miR-34c-5p/Notch in epithelial-mesenchymal transition (EMT) in endometriosis. 61
32353411 2020
44
Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis. 61
33072202 2020
45
[Herb-separated moxibustion on dysmenorrhea in ovarian endometriosis: a randomized controlled trial]. 61
32648394 2020
46
Novel MYH8 mutations in 152 Han Chinese samples with ovarian endometriosis. 61
32308057 2020
47
Hospital-Associated Cost of Endometriosis in Canada: A Population-Based Study. 61
31521859 2020
48
MRI image features and differential diagnoses of Herlyn-Werner-Wunderlich syndrome. 61
31657238 2020
49
Adenomyosis and endometriosis in adolescents and young women with pelvic pain: prevalence and risk factors. 61
32549030 2020
50
Oocyte cryopreservation for fertility preservation in women with ovarian endometriosis. 61
32295746 2020
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Variations for Endometriosis of Ovary

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Expression for Endometriosis of Ovary

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Search GEO for disease gene expression data for Endometriosis of Ovary.
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Pathways for Endometriosis of Ovary

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Pathways related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 36
11.75 MIR9-1 MIR30E MIR145 MIR141
2
MNAR-PELP1 and Estrogen Receptor Interaction 63
10.52 ESR2 ESR1
3
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 60
9.4 ESR2 ESR1 CYP19A1
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GO Terms for Endometriosis of Ovary

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Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 estrogen biosynthetic process GO:0006703 9.16 HSD17B2 CYP19A1
2 intracellular steroid hormone receptor signaling pathway GO:0030518 8.96 ESR2 ESR1
3 intracellular estrogen receptor signaling pathway GO:0030520 8.8 ESR2 ESR1 ARID1A

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.46 MIR9-1 MIR30E MIR145 MIR141
2 estrogen receptor activity GO:0030284 8.96 ESR2 ESR1
3 estrogen response element binding GO:0034056 8.62 ESR2 ESR1
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Sources for Endometriosis of Ovary

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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