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MCID: END011
MIFTS: 40

Endometriosis of Ovary

Categories: Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endometriosis of Ovary

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MalaCards integrated aliases for Endometriosis of Ovary:

Name: Endometriosis of Ovary 12 15 71 32
Ovarian Endometriosis 12 17

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:11432
ICD9CM 34 617.1
NCIt 49 C27628
SNOMED-CT 67 31007005
ICD10 32 N80.1
UMLS 71 C0156344
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Summaries for Endometriosis of Ovary

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Disease Ontology : 12 A female reproductive system disease characterized by the growth of endometrial tissue that is located in the ovary.

MalaCards based summary : Endometriosis of Ovary, also known as ovarian endometriosis, is related to endometriosis and ovarian cyst. An important gene associated with Endometriosis of Ovary is MIR141 (MicroRNA 141), and among its related pathways/superpathways are MicroRNAs in cancer and Nuclear Receptor transcription pathway. The drugs Anastrozole and Goserelin have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and uterus.

Wikipedia : 74 Endometrioma is the presence of endometrial tissue in and sometimes on the ovary. It is the most common... more...

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Related Diseases for Endometriosis of Ovary

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Diseases related to Endometriosis of Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 206)
# Related Disease Score Top Affiliating Genes
1 endometriosis 30.7 PGR MIR145 MIR141 ESR2 ESR1 CYP19A1
2 ovarian cyst 30.5 MIR145 MIR141 ESR2 CYP19A1 AMH
3 intravenous leiomyomatosis 30.2 PGR ESR1
4 intestinal disease 30.2 MIR9-1 MIR30E MIR145 MIR141
5 serous cystadenocarcinoma 30.1 PGR ESR2 ARID1A
6 clear cell adenocarcinoma 30.1 PGR ESR1 ARID1A
7 myoma 29.9 PGR ESR1 CYP19A1 AMH
8 in situ carcinoma 29.9 PGR ESR1 CYP19A1
9 progesterone resistance 29.9 PGR ESR2 ESR1
10 adenomyosis 29.9 PGR ESR2 ESR1 CYP19A1
11 adenomyoma 29.9 PGR ESR1
12 leiomyoma 29.9 PGR ESR2 ESR1 CYP19A1
13 ovarian serous cystadenocarcinoma 29.8 PGR ESR2 ARID1A
14 ovarian clear cell adenocarcinoma 29.8 PGR ESR2 ARID1A
15 ovary adenocarcinoma 29.8 PGR ESR1 ARID1A
16 leiomyoma, uterine 29.7 PGR ESR2 ESR1 CYP19A1
17 endometrial adenocarcinoma 29.5 PGR ESR2 ESR1
18 endometrial stromal sarcoma 29.4 PGR ESR2 ESR1 CYP19A1
19 estrogen excess 29.2 PGR ESR2 ESR1 CYP19A1
20 endometrial hyperplasia 28.9 PGR ESR2 ESR1 CYP19A1 ARID1A
21 endometrial cancer 28.8 PGR MIR145 ESR2 ESR1 CYP19A1 ARID1A
22 ovarian cancer 28.7 PGR MIR9-1 MIR34B MIR30E MIR145 MIR141
23 ovarian disease 28.6 PGR MIR145 ESR2 ESR1 CYP19A1 ARID1A
24 extrapelvic endometriosis 10.4
25 infertility 10.4
26 subserous uterine fibroid 10.4 PGR AMH
27 bile duct disease 10.4 MIR9-1 MIR30E MIR145
28 biliary tract disease 10.3 MIR9-1 MIR30E MIR145
29 cervix disease 10.3 MIR9-1 MIR34B MIR145 MIR141
30 cell type cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
31 arteries, anomalies of 10.3 MIR9-1 MIR30E MIR145 MIR141
32 pancreas disease 10.3 MIR9-1 MIR30E MIR145 MIR141
33 male reproductive organ cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
34 papillary serous adenocarcinoma 10.3 PGR MIR30E MIR141
35 male reproductive system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
36 urinary system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
37 large intestine cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
38 female reproductive system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
39 respiratory system cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
40 benign metastasizing leiomyoma 10.3 PGR CYP19A1
41 papillary adenocarcinoma 10.3 PGR MIR30E MIR141
42 endocrine gland cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
43 respiratory system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
44 gastrointestinal system cancer 10.3 MIR9-1 MIR30E MIR145 MIR141
45 endocrine system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
46 gastrointestinal system disease 10.3 MIR9-1 MIR30E MIR145 MIR141
47 pharynx cancer 10.3 MIR9-1 MIR30E MIR145
48 postmenopausal atrophic vaginitis 10.2 ESR1 CYP19A1
49 ovarian clear cell carcinoma 10.2
50 ovarian epithelial cancer 10.2

Comorbidity relations with Endometriosis of Ovary via Phenotypic Disease Network (PDN):


Fallopian Tube Endometriosis Myofibroma

Graphical network of the top 20 diseases related to Endometriosis of Ovary:



Diseases related to Endometriosis of Ovary
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Symptoms & Phenotypes for Endometriosis of Ovary

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Drugs & Therapeutics for Endometriosis of Ovary

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Drugs for Endometriosis of Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 4 120511-73-1 2187
2
Goserelin Approved Phase 4 65807-02-5, 1233494-97-7 47725 5311128
3 Estrogens Phase 4
4 Aromatase Inhibitors Phase 4
5 Estrogen Antagonists Phase 4
6 Steroid Synthesis Inhibitors Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Estrogen Receptor Antagonists Phase 4
9
Medroxyprogesterone acetate Approved, Investigational Phase 2 71-58-9
10
Medroxyprogesterone Phase 2 520-85-4 10631
11 Hormone Antagonists
12 Hormones
13 Hemostatics
14 Coagulants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Arimidex and Zoladex as Pretreatment to IVF in Women With Ovarian Endometriosis Completed NCT00286351 Phase 4 Combined treatment with Arimidex and Zoladex before IVF
2 A Phase IIa Efficacy and Safety Study of PGL5001 Versus Placebo Administered for up to 5 Months With Concomitant Administration of Depot Medroxyprogesterone Acetate for the Treatment of Peritoneal and/or Ovarian Endometriosis With an Inflammatory Component. Completed NCT01630252 Phase 2 PGL5001;Placebo;PGL5001;Placebo;PGL5001
3 "Identification, Characterization and Isolation of Somatic Stem Cells in Human Endometrium of Women With Endometriosis" Unknown status NCT01412138
4 Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy Completed NCT03826355
5 Optimum Menstrual Cycle Time for Endometrioma Excision Recruiting NCT03484546
6 Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma: A Randomized Control Trial Recruiting NCT03430609
7 Perinatal Consequences of Endometriosis: Multicenter Prospective Comparative Study Active, not recruiting NCT02498691
8 Study of the Relationship Between Oxidative Stress Gene Polymorphism and Individual Variation of Ovarian Reserve Function in Patients With Ovarian Endometrioma Not yet recruiting NCT03682341

Search NIH Clinical Center for Endometriosis of Ovary

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Genetic Tests for Endometriosis of Ovary

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Anatomical Context for Endometriosis of Ovary

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The Foundational Model of Anatomy Ontology organs/tissues related to Endometriosis of Ovary:

19
Ovary

MalaCards organs/tissues related to Endometriosis of Ovary:

40
Ovary, Breast, Uterus, Cervix, Endothelial, Colon, Liver
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Publications for Endometriosis of Ovary

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Articles related to Endometriosis of Ovary:

(show top 50) (show all 769)
# Title Authors PMID Year
1
Long noncoding RNA CHL1-AS1 promotes cell proliferation and migration by sponging miR-6076 to regulate CHL1 expression in endometrial cancer. 61
31736153 2020
2
Painful Love: Superficial Dyspareunia and Three Dimensional Transperineal Ultrasound Evaluation of Pelvic Floor Muscle in Women with Endometriosis. 61
31612796 2020
3
Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis. 61
31610174 2020
4
The recent progress and therapy in endometriosis-associated ovarian cancer. 61
31985569 2020
5
The relationship between ovarian endometriosis and clinical pregnancy and abortion rate based on logistic regression model. 61
31889882 2020
6
Is dienogest the best medical treatment for ovarian endometriomas? Results of a multicentric case control study. 61
31311360 2020
7
Ginsenoside Rg3 attenuates endometriosis by inhibiting the viability of human ectopic endometrial stromal cells through the nuclear factor-kappaB signaling pathway. 61
31563698 2020
8
Is there a correlation between inflammatory markers and coagulation parameters in women with advanced ovarian endometriosis? 61
31888633 2019
9
Unusual uptake of 131iodine in bilateral ovarian endometriosis cysts in a patient with thyroid cancer. 61
31502210 2019
10
Expression profiles of tRNA-derived fragments and their potential roles in ovarian endometriosis. 61
31845823 2019
11
E2 -mediated EMT by activation of β-catenin/Snail signalling during the development of ovarian endometriosis. 61
31560827 2019
12
Right postoperative pleural effusion and pulmonary embolism following laparoscopic gynecological surgery: A rare case report and PRISMA-driven systematic review. 61
31135576 2019
13
An assessment of the multifactorial profile of steroid-metabolizing enzymes and steroid receptors in the eutopic endometrium during moderate to severe ovarian endometriosis. 61
31878927 2019
14
GLI1 is increased in ovarian endometriosis and regulates migration, invasion and proliferation of human endometrial stromal cells in endometriosis. 61
31930064 2019
15
Endometriosis and risk of ovarian cancer: what do we know? 61
31745637 2019
16
Factors associated with ovarian endometriosis malignancy and its recurrence in Chinese women. 61
31307261 2019
17
Investigating the impact of local inflammation on granulosa cells and follicular development in women with ovarian endometriosis. 61
31551156 2019
18
Ovarian endometrioma - a possible finding in adolescent girls and young women: a mini-review. 61
31699129 2019
19
The role of survivin in the pathogenesis of endometriosis. 61
31755675 2019
20
Expressions of natural cytotoxicity receptor, NKG2D and NKG2D ligands in endometriosis. 61
31655348 2019
21
Deep endometriosis transvaginal ultrasound in the workup of patients with signs and symptoms of endometriosis: a cost analysis. 61
31452295 2019
22
Reprint of: Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities. 61
31623724 2019
23
Usefulness of subtraction pelvic magnetic resonance imaging for detection of ovarian endometriosis. 61
31661751 2019
24
Different mutation profiles between epithelium and stroma in endometriosis and normal endometrium. 61
31621846 2019
25
MRI image features and differential diagnoses of Herlyn-Werner-Wunderlich syndrome. 61
31657238 2019
26
Adverse effects of endometriosis on pregnancy: a case-control study. 61
31640604 2019
27
Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis. 61
31318420 2019
28
Estrogen receptor 1 mutations in 260 cervical cancer samples from Chinese patients. 61
31452755 2019
29
Decreased Level of Neurotrophic Factor Neuritin 1 in Women with Ovarian Endometriosis after Receiving Gonadotropin-Releasing Hormone Agonist Treatment. 61
31491902 2019
30
Quality of Life Assessment by the Endometriosis Health Profile (EHP-30) Questionnaire Prior to Treatment for Ovarian Endometriosis in Brazilian Women. 61
31480078 2019
31
Impaired Localization of Claudin-11 in Endometriotic Epithelial Cells Compared to Endometrial Cells. 61
30514158 2019
32
Inhibition of KIF20A by BKS0349 reduces endometriotic lesions in a xenograft mouse model. 61
31365745 2019
33
Preoperative serum anti-Müllerian hormone level is a potential predictor of ovarian endometrioma severity and postoperative fertility. 61
31255930 2019
34
Hospital-Associated Cost of Endometriosis in Canada: A Population-Based Study. 61
31521859 2019
35
MRI features and differential diagnoses of congenital vaginal atresia. 61
30982355 2019
36
Endometriosis of the duplex appendix: A case report and review of the literature. 61
31423443 2019
37
Recurrence Rate after "One-Step" CO2 Fiber Laser Vaporization versus Cystectomy for Ovarian Endometrioma: A 3-Year Follow-up Study. 61
31377455 2019
38
Roles of cell migration and invasion mediated by Twist in endometriosis. 61
31250947 2019
39
Comprehensive immune complexome analysis detects disease-specific immune complex antigens in seminal plasma and follicular fluids derived from infertile men and women. 61
31158356 2019
40
Risk factors for postoperative recurrence of ovarian endometriosis: long-term follow-up of 358 women. 61
31470880 2019
41
Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis-associated tumorigenesis. 61
31022415 2019
42
Pregnancy after Endometriosis: Maternal and Neonatal Outcomes according to the Location of the Disease. 61
31238367 2019
43
Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis. 61
31144476 2019
44
Elevated urine histone 4 levels in women with ovarian endometriosis revealed by discovery and parallel reaction monitoring proteomics. 61
31146047 2019
45
Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality. 61
31211846 2019
46
A randomized controlled trial of a new technique for laparoscopic management of ovarian endometriosis preventing recurrence and keeping ovarian reserve. 61
31325962 2019
47
Leyomiomatosis peritonealis disseminata associated with ovarian endometriosis in a patient submitted to hysteroscopic myomectomy. 61
31030890 2019
48
Aberrant methylation of the IL-12B promotor region contributes to the risk of developing ovarian endometriosis. 61
30865360 2019
49
Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway. 61
31023528 2019
50
Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis. 61
30882467 2019
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Variations for Endometriosis of Ovary

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Expression for Endometriosis of Ovary

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Search GEO for disease gene expression data for Endometriosis of Ovary.
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Pathways for Endometriosis of Ovary

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Pathways related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
MicroRNAs in cancer 36
12.05 MIR9-1 MIR34B MIR30E MIR145 MIR141
2
Nuclear Receptor transcription pathway 65
Show member pathways
 11.39 PGR ESR2 ESR1
3
Ovarian Infertility Genes 1
10.64 PGR ESR2 CYP19A1
4
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics 60
9.4 ESR2 ESR1 CYP19A1
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GO Terms for Endometriosis of Ovary

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Biological processes related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 uterus development GO:0060065 9.26 ESR1 CYP19A1
2 gene silencing by miRNA GO:0035195 9.26 MIR9-1 MIR30E MIR145 MIR141
3 androgen metabolic process GO:0008209 9.16 ESR1 CYP19A1
4 intracellular estrogen receptor signaling pathway GO:0030520 8.8 ESR2 ESR1 ARID1A

Molecular functions related to Endometriosis of Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.67 MIR9-1 MIR30E MIR145 MIR141
2 steroid hormone receptor activity GO:0003707 9.5 PGR ESR2 ESR1
3 nuclear receptor activity GO:0004879 9.33 PGR ESR2 ESR1
4 estrogen receptor activity GO:0030284 9.26 ESR2 ESR1
5 estrogen response element binding GO:0034056 8.96 ESR2 ESR1
6 steroid binding GO:0005496 8.8 PGR ESR2 ESR1
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Sources for Endometriosis of Ovary

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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