MCID: END045
MIFTS: 33

Endometriosis of Uterus

Categories: Reproductive diseases

Aliases & Classifications for Endometriosis of Uterus

MalaCards integrated aliases for Endometriosis of Uterus:

Name: Endometriosis of Uterus 12 15 73
Endometriosis of Myometrium 12
Endometriosis, Myometrium 12
Endometriosis Interna 12
Uterine Adenomyosis 12
Adenomyosis 44

Classifications:



External Ids:

Disease Ontology 12 DOID:288
ICD10 33 N80.0
ICD9CM 35 617.0
MeSH 44 D062788
NCIt 50 C6996
UMLS 73 C0341858

Summaries for Endometriosis of Uterus

MalaCards based summary : Endometriosis of Uterus, also known as endometriosis of myometrium, is related to adenomyosis and organ system benign neoplasm. An important gene associated with Endometriosis of Uterus is HPSE2 (Heparanase 2 (Inactive)), and among its related pathways/superpathways are Signaling by ERBB4 and Signaling events mediated by PTP1B. The drugs Acetaminophen and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include uterus, testes and brain, and related phenotype is integument.

Related Diseases for Endometriosis of Uterus

Diseases related to Endometriosis of Uterus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 adenomyosis 11.1
2 organ system benign neoplasm 10.3 HPSE2 PRL
3 galactorrhea 10.2 PRL PRLR
4 extrapelvic endometriosis 10.1
5 pituitary infarct 9.9 GNRH1 PRL
6 hypogonadotropism 9.9 GNRH1 PRL
7 hypothalamic disease 9.9 GNRH1 PRL
8 breast disease 9.9 PRL PRLR
9 chiasmal syndrome 9.9 GNRH1 PRL
10 pituitary apoplexy 9.8 GNRH1 PRL
11 empty sella syndrome 9.8 GNRH1 PRL
12 diabetes insipidus, neurohypophyseal 9.8 GNRH1 PRL
13 sex differentiation disease 9.8 GNRH1 PRL
14 premenstrual tension 9.8 GNRH1 PRL
15 pituitary-dependent cushing's disease 9.8 GNRH1 PRL
16 anovulation 9.8 GNRH1 PRL
17 varicocele 9.8 GNRH1 PRL
18 pituitary gland disease 9.7 GNRH1 PRL
19 female reproductive system disease 9.7 GNRH1 PRL
20 myoma 9.7 GNRH1 HPSE2
21 craniopharyngioma 9.7 GNRH1 PRL
22 hyperandrogenism 9.7 GNRH1 PRL
23 amenorrhea 9.6 GNRH1 PRL
24 hypopituitarism 9.6 GNRH1 PRL
25 reproductive system disease 9.6 GNRH1 PRL
26 premature ovarian failure 1 9.4 GNRH1 PRL
27 ovarian disease 9.3 GNRH1 PRL
28 chromophobe adenoma 9.3 GNRH1 PRL PRLR
29 hyperprolactinemia 9.3 GNRH1 PRL PRLR
30 infertility 9.2 GNRH1 PRL PRLR
31 polycystic ovary syndrome 9.1 GNRH1 PRL

Comorbidity relations with Endometriosis of Uterus via Phenotypic Disease Network (PDN):


Asherman's Syndrome Cervix Uteri Carcinoma in Situ
Chronic Salpingo-Oophoritis Endometriosis of Ovary
Fallopian Tube Endometriosis Female Stress Incontinence
Myofibroma Submucous Uterine Fibroid
Subserous Uterine Fibroid

Graphical network of the top 20 diseases related to Endometriosis of Uterus:



Diseases related to Endometriosis of Uterus

Symptoms & Phenotypes for Endometriosis of Uterus

MGI Mouse Phenotypes related to Endometriosis of Uterus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 GNRH1 PRL PRLR SMTN

Drugs & Therapeutics for Endometriosis of Uterus

Drugs for Endometriosis of Uterus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
4 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
5 Analgesics Phase 4,Phase 3
6 Analgesics, Non-Narcotic Phase 4
7 Anti-Inflammatory Agents Phase 4,Not Applicable
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Antipyretics Phase 4
10 Antirheumatic Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Ramosetron Approved, Investigational Phase 3 132036-88-5
13
Goserelin Approved Phase 2, Phase 3 65807-02-5 47725 5311128
14
Letrozole Approved, Investigational Phase 2, Phase 3 112809-51-5 3902
15
Lactitol Investigational Phase 2, Phase 3 585-86-4 3871
16 Antiemetics Phase 3,Not Applicable
17 Autonomic Agents Phase 3,Not Applicable
18 Gastrointestinal Agents Phase 3,Not Applicable
19 Neurotransmitter Agents Phase 3,Phase 1
20 Serotonin Agents Phase 3
21 Serotonin Antagonists Phase 3
22 Estrogens Phase 2, Phase 3,Not Applicable,Early Phase 1
23 Hormone Antagonists Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
24 Hormones Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Phase 1,Not Applicable,Early Phase 1
26 Antineoplastic Agents, Hormonal Phase 2, Phase 3,Not Applicable
27 Aromatase Inhibitors Phase 2, Phase 3
28 Estrogen Antagonists Phase 2, Phase 3
29 Steroid Synthesis Inhibitors Phase 2, Phase 3
30 Micronutrients Phase 3
31 Trace Elements Phase 3
32
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
33
Levonorgestrel Approved, Investigational Phase 2,Not Applicable,Early Phase 1 797-63-7, 17489-40-6 13109
34
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
35
Ropivacaine Approved Phase 2 84057-95-4 71273 175805
36 Contraceptive Agents Phase 2,Not Applicable,Early Phase 1
37 Contraceptives, Oral Phase 2,Not Applicable,Early Phase 1
38 Contraceptives, Oral, Combined Phase 2,Not Applicable,Early Phase 1
39 Anesthetics Phase 2,Not Applicable
40 Anesthetics, Local Phase 2
41 Anti-Arrhythmia Agents Phase 2
42 Central Nervous System Depressants Phase 2
43 Diuretics, Potassium Sparing Phase 2,Early Phase 1
44 Sodium Channel Blockers Phase 2
45
Bromocriptine Approved, Investigational Phase 1 25614-03-3 31101
46
Dopamine Approved Phase 1 51-61-6, 62-31-7 681
47 Antiparkinson Agents Phase 1
48 Dopamine Agents Phase 1
49 Dopamine agonists Phase 1
50
Estradiol Approved, Investigational, Vet_approved Not Applicable,Early Phase 1 50-28-2 5757

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Effectiveness of IV Acetaminophen and IV Ibuprofen in Reducing Post Procedural Pain in the UFE Procedure Completed NCT02227316 Phase 4 IV Ibuprofen;IV Acetaminophen;Intravenous placebo/Intravenous placebo
2 Effect of Ulipristal Acetate on Bleeding Patterns and Dysmenorrhea in Women With Adenomyosis Withdrawn NCT03325868 Phase 4 Ulipristal Acetate
3 The Use of Doppler to Diagnose Myometrial Masses Unknown status NCT01833871 Phase 2, Phase 3
4 Single Incision Laparoscopic Surgery (SILS) Versus Conventional Laparoscopic Hysterectomy Unknown status NCT01483417 Phase 3
5 Single-port Access Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01048931 Phase 3
6 Long Term Prevention of Nausea and Vomiting in Gynecologic Laparoscopy Unknown status NCT02011659 Phase 3 Ramosetron
7 Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis Completed NCT01218581 Phase 2, Phase 3 received oral letrozole (2.5 mg/day)and goserelin subcutaneosly (3.6 mg/month)
8 Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy Completed NCT01064128 Phase 3
9 Evaluation of Therapeutic Effect and Safety of Mifepristone in the Treatment of Adenomyosis Recruiting NCT03520439 Phase 2, Phase 3 Mifepristone;Placebo
10 Efficacy of Trace Elements in the Treatment of Endometriosis: a Pilot Study Active, not recruiting NCT02437175 Phase 3
11 LNG-IUS for Treatment of Dysmenorrhea Completed NCT01601366 Phase 2 Combined oral contraceptives
12 Tactile Electrosurgical Ablation in Cases of Dysfunctional Uterine Bleeding Completed NCT02248194 Phase 2
13 Superior Hypogastric Nerve Block for Pain Control Post-UFE Completed NCT02270255 Phase 2 0.75% Ropivacaine;1% Xylocaine
14 Adenomyosis and Ulipristal Acetate Recruiting NCT02587000 Phase 2 Ulipristal acetate;Placebo
15 Placebo-controlled Proof of Concept Study of Epelsiban in Women With Adenomyosis Withdrawn NCT02794467 Phase 2 Epelsiban;Placebo
16 Vaginal Bromocriptine for Treatment of Adenomyosis Completed NCT01821001 Phase 1 Vaginal Bromocriptine
17 Efficacy of Acupuncture on Chronic Pelvic Pain in Women With Endometriosis or Adenomyosis Unknown status NCT01259180 Not Applicable
18 Evaluation of Endometrial Stromal Cell Apoptosis in Adenomyosis Unknown status NCT00172588
19 Proliferation of Endometrial Stromal Cells in Adenomyosis Unknown status NCT00173212
20 Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS) Unknown status NCT02556411 Not Applicable LNG-IUS 13,5 mg Levonorgestrel;Levonorgestrel 0,10 mg+ ethinylestradiol 0,02 mg
21 Health-Related QoL Among Women Receiving Hysterectomy in NTUH Unknown status NCT00155870
22 Progestin Treatment for Endometrial Stromal Cells in Adenomyosis Unknown status NCT00155051
23 To Compare to 2-channel and Multiple-channel Single Port Laparoscopic-assisted Vaginal Hysterectomy Unknown status NCT01564602 Not Applicable
24 The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH) Unknown status NCT00928044
25 Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy Unknown status NCT01289314 Not Applicable
26 Histopathological Diagnosis of Adenomyosis Completed NCT02340533 Not Applicable
27 Norwegian Adenomyosis Study I Completed NCT02201719
28 Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis Completed NCT03027648 Not Applicable
29 Levonorgestrel Intrauterine System and Adenomyosis Completed NCT03104309 Not Applicable
30 New Inflammation Markers for Distinguishing Uterine Adenomyosis and Leiomyoma Completed NCT02997787
31 What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography Completed NCT01992718 Early Phase 1
32 Use of Dexamethasone in Uterine Artery Embolization Completed NCT02056717 Not Applicable Dexamethasone;Normal saline
33 Uterine Artery Embolization for Symptomatic Fibroids Completed NCT00354471
34 AMH Levels Change During Treatment With GnRh Agonist Completed NCT02086279 Not Applicable GnRH analogue
35 Does 3D Laparoscopy Improve Vaginal Cuff Suture Time? Completed NCT02192606 Not Applicable
36 Use of the Enseal Intrument for Laparoscopic Supracervical Hysterectomy Completed NCT01806012 Not Applicable
37 Magnetic Resonance Imaging (MRI) Hysterosalpingography Versus Radiographic Hysterosalpingography in Female Infertility Completed NCT02108665 Not Applicable
38 Surgical Success After Laparoscopic vs Abdominal Hysterectomy Completed NCT01793584 Not Applicable
39 Electronic Catheter Stethoscope Completed NCT01463462
40 Sonohysterography , 3D Ultrasonography and Hysteroscopy in Assessment of Uterine Factor in Cases of Female Infertility Completed NCT02399501 Not Applicable
41 The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms Recruiting NCT02495311
42 Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri Recruiting NCT03037944 Early Phase 1 Yasmin
43 Development and Validation of EHP-30 (Hong Kong Chinese Version) for Patients With Endometriosis and Adenomyosis Recruiting NCT03302468
44 Cooperative Adenomyosis Network Recruiting NCT03230994
45 Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU) Recruiting NCT02914704 Not Applicable
46 Ovarian Reserve Modification After Lps Hysterectomy With Bilateral Salpingectomy Recruiting NCT02086344 Not Applicable
47 Effect of Shorten Gonadotropin-releasing Hormone Agonist Therapy on the Outcome of in Vitro Fertilization-Embryo Transfer in Patients With Endometriosis Recruiting NCT03006406 Not Applicable Long term GnRH-a (3.75mg)
48 Acceptability and Tolerance of Hysteroscopy and Hysterosonography in Consultation Recruiting NCT03121560 Not Applicable
49 Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis Active, not recruiting NCT02197923
50 Effect of Salpingectomy During Conservative Hysterectomy Active, not recruiting NCT01628432 Not Applicable

Search NIH Clinical Center for Endometriosis of Uterus

Cochrane evidence based reviews: adenomyosis

Genetic Tests for Endometriosis of Uterus

Anatomical Context for Endometriosis of Uterus

MalaCards organs/tissues related to Endometriosis of Uterus:

41
Uterus, Testes, Brain

Publications for Endometriosis of Uterus

Articles related to Endometriosis of Uterus:

# Title Authors Year
1
[The clinical importance of the dopplerometric study of the blood flow in the normal iliac, uterine and ovarian arteries, in myoma and in endometriosis interna of the corpus uteri]. ( 7785736 )
1995
2
[The clinical picture, diagnosis and treatment of the corpus-isthmus location of uterine endometriosis interna]. ( 8048686 )
1993

Variations for Endometriosis of Uterus

Expression for Endometriosis of Uterus

Search GEO for disease gene expression data for Endometriosis of Uterus.

Pathways for Endometriosis of Uterus

Pathways related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.19 PRL PRLR
2 10.65 PRL PRLR
3
Show member pathways
10.24 PRL PRLR

GO Terms for Endometriosis of Uterus

Cellular components related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 PRL PRLR

Biological processes related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.16 GNRH1 PRL
2 lactation GO:0007595 8.96 PRL PRLR
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 PRL PRLR

Molecular functions related to Endometriosis of Uterus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 GNRH1 PRL

Sources for Endometriosis of Uterus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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