MCID: END046
MIFTS: 46

Endometritis

Categories: Reproductive diseases

Aliases & Classifications for Endometritis

MalaCards integrated aliases for Endometritis:

Name: Endometritis 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1002
MeSH 44 D004716
NCIt 50 C26764
SNOMED-CT 67 155975003
UMLS 70 C0014179

Summaries for Endometritis

Disease Ontology : 12 An endometrial disease that is characterized by inflammation of the endometrium.

MalaCards based summary : Endometritis is related to granulomatous endometritis and salpingitis. An important gene associated with Endometritis is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Doxycycline and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and breast, and related phenotype is neoplasm.

Wikipedia : 73 Endometritis is inflammation of the inner lining of the uterus (endometrium). Symptoms may include... more...

Related Diseases for Endometritis

Diseases in the Endometritis family:

Acute Endometritis

Diseases related to Endometritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 647)
# Related Disease Score Top Affiliating Genes
1 granulomatous endometritis 32.3 SDC1 PGR ESR1
2 salpingitis 31.9 TNF SIGLEC5 IL6
3 chlamydia 30.5 TNF TLR4 IL6 IL1B CXCL8
4 pelvic inflammatory disease 30.4 TLR4 SIGLEC5 LACTB HLA-DQA1
5 myoma 30.4 PGR OXT ESR1
6 mastitis 30.4 OXT IL6 HP CXCL8
7 endometriosis 30.3 PGR IL6 IL1B ESR1 CXCL8
8 leiomyoma, uterine 30.3 PGR MIRLET7C MIR27A ESR1
9 vaginal discharge 30.2 TNF PGR OXT IL6 IL1B HP
10 human cytomegalovirus infection 30.2 IL6 IL1B CXCL8
11 thyroiditis 30.2 TNF IL6 IL1B
12 streptococcal toxic-shock syndrome 30.2 TNF IL6 CXCL8
13 bacterial vaginosis 30.1 TNF TLR4 IL6 IL1B CXCL8
14 meningoencephalitis 30.1 TNF IL6 IL1B
15 vaginitis 30.1 TNF IL6 IL1B ESR1 CXCL8
16 haemophilus influenzae 30.1 TNF LACTB CXCL8
17 cellulitis 30.0 TNF LACTB IL6
18 adenomyosis 30.0 PGR OXT IL6 ESR1 CXCL8
19 cervicitis 30.0 TNF TLR4 IL6 IL1B CXCL8
20 trichomoniasis 30.0 TNF IL6 IL1B CXCL8
21 acute gonococcal cervicitis 29.9 IL6 CXCL8
22 peritonitis 29.8 TNF TLR4 IL6 IL1B CXCL8 CXCL1
23 chorioamnionitis 29.8 TNF TLR4 OXT IL6 IL1B CXCL8
24 pulmonary tuberculosis 29.8 TNF IL6 HP HLA-DQB1
25 stomatitis 29.8 TNF IL6 IL1B CXCL8
26 diverticulitis 29.8 TNF SDC1 IL6
27 leptospirosis 29.8 TNF IL6 IL1B CXCL8
28 exanthem 29.8 TNF IL6 IL1B CXCL8
29 ovarian disease 29.7 TNF PGR MIR27A IL6 ESR1
30 endocarditis 29.7 TNF LACTB IL6 CXCL8
31 pyometritis 29.7 PGR HP
32 toxic shock syndrome 29.6 TNF TLR4 IL6 IL1B CXCL8
33 adult respiratory distress syndrome 29.6 TNF IL6 IL1B CXCL8 CXCL1
34 q fever 29.5 TNF TLR4 IL6 IL1B
35 conjunctivitis 29.5 TNF TLR4 IL6 CXCL8
36 bacterial infectious disease 29.5 TNF TLR4 IL6 IL1B CXCL8
37 cystitis 29.5 TNF TLR4 IL6 CXCL8 CXCL1
38 bacteriuria 29.5 TLR4 IL6 CXCL8 CXCL1
39 pulmonary disease, chronic obstructive 29.4 TNF SIGLEC5 IL6 IL1B CXCL8
40 measles 29.4 TNF TLR4 IL6 IL1B HLA-DQA1
41 urethritis 29.4 TNF TLR4 IL6 IL1B CXCL8
42 immune deficiency disease 29.3 TNF SIGLEC5 MIR27A IL6 IL1B HLA-DQB1
43 acute cystitis 29.3 TNF TLR4 IL6 IL1B CXCL8 CXCL1
44 pre-eclampsia 29.2 TNF TLR4 OXT IL6 IL1B CXCL8
45 appendicitis 29.1 TNF TLR4 IL6 IL1B CXCL8
46 pyelonephritis 29.1 TNF TLR4 IL6 IL1B CXCL8
47 candidiasis 29.1 TNF TLR4 IL6 IL1B CXCL8
48 viral infectious disease 29.1 TNF TLR4 IL6 IL1B CXCL8
49 meningitis 29.1 TNF TLR4 LACTB IL6 IL1B CXCL8
50 eye disease 29.0 TNF SDC1 MIR27A IL6 IL1B CXCL8

Graphical network of the top 20 diseases related to Endometritis:



Diseases related to Endometritis

Symptoms & Phenotypes for Endometritis

MGI Mouse Phenotypes related to Endometritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.23 ESR1 HP IL1B IL6 PGR SDC1

Drugs & Therapeutics for Endometritis

Drugs for Endometritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4 Antiparasitic Agents Phase 4
5 Antimalarials Phase 4
6 Antiprotozoal Agents Phase 4
7 Plasma Substitutes Phase 4
8 Blood Substitutes Phase 4
9 beta-Lactams Phase 4
10 Lactams Phase 4
11 Gentamicins Phase 4
12 Antitubercular Agents Phase 4
13 Clindamycin phosphate Phase 4
14 Clindamycin palmitate Phase 4
15
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
16
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
17
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
18
Metronidazole Approved Phase 2 443-48-1 4173
19
Chlorhexidine Approved, Vet_approved Phase 1, Phase 2 55-56-1 9552079 2713
20
Cefoxitin Approved Phase 2 35607-66-0 441199
21
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
22
Ofloxacin Approved Phase 2 82419-36-1 4583
23
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
24 Chlorhexidine gluconate Phase 1, Phase 2
25 Pharmaceutical Solutions Phase 1, Phase 2
26 Disinfectants Phase 1, Phase 2
27 Dermatologic Agents Phase 1, Phase 2
28
Ertapenem Approved, Investigational Phase 1 153832-46-3 150610
29
Methylergonovine Approved 113-42-8 8226
30
Tinidazole Approved, Investigational 19387-91-8 5479
31
Curcumin Approved, Experimental, Investigational 458-37-7 969516
32
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
33
Povidone Approved 9003-39-8 131751496
34
Povidone-iodine Approved 25655-41-8
35
Iodine Approved, Investigational 7553-56-2 807
36
Progesterone Approved, Vet_approved 57-83-0 5994
37
Cadexomer iodine Experimental 94820-09-4
38 Amoxicillin-Potassium Clavulanate Combination
39 Clavulanic Acids
40 beta-Lactamase Inhibitors
41 Alkylating Agents
42 Cytochrome P-450 Enzyme Inhibitors
43 Calamus
44 Antirheumatic Agents
45 Anti-Inflammatory Agents
46 Analgesics, Non-Narcotic
47 Anti-Inflammatory Agents, Non-Steroidal
48 Analgesics
49 Acidophilus
50 Anti-Infective Agents, Local

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Preoperative Vaginal Cleansing With Povidone Iodine and the Risk of Post Cesarean Endometritis Unknown status NCT02693483 Phase 4 10% povidone iodine
2 SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle Completed NCT01242852 Phase 4
3 Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis? Completed NCT01437228 Phase 4 povidone- iodine solution.;placebo
4 Efficacy and Side-Effects of Two Dosing Regimens of Doxycycline at Surgical Abortion: A Randomized Double-Blind Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
5 Antibiotics During Intrauterine Balloon Tamponade Placement Recruiting NCT03478163 Phase 4 CeFAZolin 1000 MG;Clindamycin 900 MG in 6 ML Injection
6 Azithromycin With or Without Amoxicillin to Prevent Peripartum Infection and Sepsis in Laboring High-risk Women: 3-Arm RCT Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
7 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
8 Antibiotic Prophylaxis and Intervention for Postpartum Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
9 A Randomized Clinical Trial of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis Withdrawn NCT01721616 Phase 4 Azithromycin;Cefazolin
10 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term - a Randomized Controlled Trial Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
11 The Optimal Time for Intravenous Antibiotic Prophylaxis in Elective Cesarean Section: Randomized Comparative Study Unknown status NCT02742948 Phase 2 ceftriaxone
12 Introducing Intrauterine Antibiotic Infusion as a Novel Approach in Effectively Treating Chronic Endometritis and Restoring Reproductive Dynamics: A Pilot Study Completed NCT04447625 Phase 2 Oral antibiotic administration;Intrauterine antibiotic infusion
13 The Impact of Chlorhexidine Preoperative Vaginal Preparation in Reducing the Post-cesarean Endometritis and Sepsis for Cases in Labor. A Randomized Controlled Trial Recruiting NCT04385680 Phase 1, Phase 2 Chlorhexidine Gluconate vaginal solution 0.05%
14 Azithromycin-based Extended-spectrum Prophylaxis in Scheduled Cesarean Deliveries Recruiting NCT03960970 Phase 2 Azithromycin 500 mg;Mefoxin 2g
15 Fertility Restoration Using Autologous Adipose Tissue Derived Mesenchymal Stem Cells Enrolling by invitation NCT04432467 Phase 1, Phase 2
16 Comparative Controlled Trial of Treatment of Minor Unexpected Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy Screening in Women Indicated for IVF Terminated NCT00830401 Phase 2 Ofloxacinum/Doxycycline
17 Pharmacokinetics and Safety of Ertapenem in the Postpartum Period Terminated NCT01587495 Phase 1 Ertapenem
18 Vaginal Antimicrobacterial Preparation Before Cesarean Secation for Endometritis Prevention Unknown status NCT03093194
19 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth Unknown status NCT01945450 Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
20 The Effect of Placenta Removal Method On Postpartum Leucocytosis : A Randomized Controlled Trial Completed NCT04323241
21 Prevalence of Chronic Endometritis in Severe Intrauterine Adhesions and Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Completed NCT02744807
22 Antibiotic Prophylaxis in Ragged Placental Membranes: A Prospective, Multicenter, Randomized Trial Completed NCT03459599 Prophylactic antibiotics
23 The Impact of Chronic Endometritis on IVF Pregnancy and Pregnancy Loss Rates Completed NCT02646930
24 Supplemental Perioperative Oxygen to Reduce the Incidence of Post-Cesarean Endometritis and Wound Infection Completed NCT00670020
25 Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine Completed NCT00858832 Methergine
26 Efficacy of Intravaginal Dead Sea Peloid Gel Administration in Complex Treatment of Chronic Endometritis and Reproductive Disorders: Randomized Placebo-controlled Prospective Study Completed NCT02680275 Dead Sea Peloid Gel
27 A Prospective, Randomized,Controlled Trial on the Effect of Antibiotic Therapy on Endometrial Response in Women With Chronic Endometritis Completed NCT02648698 Antibiotics
28 Characterization of Novel Organisms in the Genital Tract of Women With PID and Determination of Their Association With Endometritis. Completed NCT01236131
29 Prevalence of Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization Completed NCT01762098
30 The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery Completed NCT01464840 Azithromycin
31 Uterine Flora During Elective and Urgent Cesarean Sections and Its Relationship to Postpartum Complications. Completed NCT00500019
32 Cesarean Section Optimal Antibiotic Prophylaxis Trial Completed NCT01235546 Azithromycin and standard of care;Placebo and standard of care
33 A Randomized, Double-Blind, Placebo Controlled Trial of Cefazolin Given Either 30 Minutes Prior to Cesarean Section or at Cord Clamping Completed NCT00330278 Cefazolin
34 A Prospective Comparative Study of Induction of Labor With a Cervical Ripening Double Balloon vs Foley Catheter Completed NCT00501033
35 Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity Completed NCT00603603
36 A Randomized Trial to Determine if a Pre-operative Wash With a Chlorhexidine Cloth Reduces Infectious Morbidity in Patients Undergoing Cesarean Section Completed NCT02402907
37 Use fo Antiseptic Solution for Vaginal Wash Before Cesarean Section in Patients With Premature Rupture of Membranes. A Randomized, Double Blind, Controlled Trial. Completed NCT03442218 Clorhexidine;Saline solution
38 Mid-Infrared Spectroscopy as a Real Time Diagnostic Tool for Chronic Endometritis Recruiting NCT04197167
39 Curcumin Supplementation for Gynecological Diseases Including Pelvic Inflammatory Disease Endometritis, Endometriosis: A Pilot Study Recruiting NCT03016039
40 Combining Vaginal Preparation and Azithromycin in Reduction of Post Cesarean Infections: A Randomized Controlled Trial Recruiting NCT04163679
41 Vaginal Cleansing Before Cesarean Delivery to Reduce Infection: A Randomized Trial Active, not recruiting NCT02495753
42 Difference in Relative Abundance of Lactobacillus in Endometrium With and Without Histologically Proven Chronic Endometritis Not yet recruiting NCT04103242
43 Comparison Between Two Protocols for Management of Prelabor Rupture of the Membranes at Term Not yet recruiting NCT04307069 Oxytocin
44 Incidence and Risk Factors for Secondary Severe Postpartum Hemorrhage in the General Population Not yet recruiting NCT03840889
45 Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments Terminated NCT03169621
46 Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial Terminated NCT00386477

Search NIH Clinical Center for Endometritis

Cochrane evidence based reviews: endometritis

Genetic Tests for Endometritis

Anatomical Context for Endometritis

MalaCards organs/tissues related to Endometritis:

40
Uterus, Placenta, Breast, Bone, Skin, Liver, Cervix

Publications for Endometritis

Articles related to Endometritis:

(show top 50) (show all 3884)
# Title Authors PMID Year
1
Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility. 54 61
19933542 2009
2
WITHDRAWN: Oxytocin for prelabour rupture of membranes at or near term. 61 54
17636608 2007
3
Oxytocin for prelabour rupture of membranes at or near term. 61 54
10796159 2000
4
Premature rupture of membranes at term: a meta-analysis of three management schemes. 61 54
9170488 1997
5
Clinical amnionitis and endometritis in patients with premature rupture of membranes: endocervical prostaglandin E2 gel versus oxytocin for induction of labor. 54 61
8841214 1996
6
Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis. 61 54
8575394 1994
7
Investigations into the use of exogenous oxytocin for promoting uterine drainage in mares susceptible to endometritis. 61 54
1897091 1991
8
Exosomes from bovine endometrial epithelial cells ensure trophoblast cell development by miR-218 targeting secreted frizzled related protein 2. 61
33230823 2021
9
Peripartum infectious morbidity in women with preeclampsia. 61
31167579 2021
10
Impact of Yeast Endometritis on Fertility in the Mare. 61
33781433 2021
11
The association of chronic endometritis with mid-trimester loss due to cervical incompetence and the outcome of laparoscopic cervical cerclage. 61
33811545 2021
12
Nutritional condition in the dry period is related to the incidence of postpartum subclinical endometritis in dairy cattle. 61
32819067 2021
13
Postpartum endometritis after uterine cleaning versus no cleaning in cesarean sections: Randomized clinical trial. 61
33438313 2021
14
Maternal morbidity by attempted route of delivery in periviable birth. 61
31242781 2021
15
Clinical Observations After Prebreeding Intrauterine Plasma Infusion in 18 Mares Inseminated With Thawed Frozen Semen. 61
33781416 2021
16
Expectant management for early pregnancy miscarriage after radical trachelectomy: a single-hospital-based study. 61
33797065 2021
17
Risk factors associated with endometritis in zero-grazed dairy cows on smallholder farms in Rwanda. 61
33454513 2021
18
Altered Gene Expression Encoding Cytochines, Grow Factors and Cell Cycle Regulators in the Endometrium of Women with Chronic Endometritis. 61
33800186 2021
19
The effects of chronic endometritis on the pregnancy outcomes. 61
33020952 2021
20
Alteration in endometrial helper T-cell subgroups in chronic endometritis. 61
33155317 2021
21
Intrauterine infusion of killed semen adversely affects uterine blood flow and endometrial gene expression of inflammatory cytokines in mares susceptible to persistent breeding-induced endometritis. 61
33493874 2021
22
Prevalence, risk factors, and effects on fertility of cytological endometritis at the time of insemination in Norwegian Red cows. 61
33741149 2021
23
Chlorogenic acid ameliorates mice clinical endometritis by activating Keap1/Nrf2 and inhibiting NFκB signalling pathway. 61
33734387 2021
24
Antibiotic therapy versus no treatment for chronic endometritis: a case-control study. 61
33722376 2021
25
Histological diagnostic criterion for chronic endometritis based on the clinical outcome. 61
33663485 2021
26
Eutopic endometrium from women with endometriosis and chlamydial endometritis share immunological cell types and DNA repair imbalance: A transcriptome meta-analytical perspective. 61
33725527 2021
27
Association of endometritis and ovarian follicular cyst with mastitis in dairy cows. 61
33342970 2021
28
Short communication: Efficacy of a second intrauterine cephapirin infusion for the treatment of purulent vaginal discharge and endometritis in postpartum dairy cows. 61
33358808 2021
29
The effect of vaginal disinfection on reducing post-caesarean endometritis: A prospective, randomised controlled trial. 61
33186774 2021
30
Different classes of antibiotics given to women routinely for preventing infection at caesarean section. 61
33661539 2021
31
Shoulder Dystocia and Composite Adverse Outcomes for the Maternal-Neonatal Dyad. 61
33757935 2021
32
Outcomes of Expectant Management of Term Prelabor Rupture of Membranes. 61
33493463 2021
33
Verbal analgesia is as good as oral tramadol prior to intrauterine device (IUD) insertion, among nulliparous women: A randomized controlled trial. 61
33187752 2021
34
Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. 61
33091407 2021
35
Office hysteroscopy before first in vitro fertilization. A randomized controlled trial. 61
33727208 2021
36
Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis. 61
33581856 2021
37
Tanshinone IIA exhibits anti-inflammatory and antioxidative effects in LPS-stimulated bovine endometrial epithelial cells by activating the Nrf2 signaling pathway. 61
33689878 2021
38
Activation of alpha7 nicotinic acetylcholine receptor protects bovine endometrial tissue against LPS-induced inflammatory injury via JAK2/STAT3 pathway and COX-2 derived prostaglandin E2. 61
33811838 2021
39
Day 7 embryo quality and suboptimal uterine environment influence morphometry of Day 16 conceptus in dairy cows. 61
33485025 2021
40
Failure of clinical cure in dairy cows treated for metritis is associated with reduced productive and reproductive performance. 61
33741169 2021
41
Vaginal Streptococcus B colonization is not associated with increased infectious morbidity in labor induction. 61
33768531 2021
42
Analysis of miRNA expression changes in bovine endometrial stromal cells treated with lipopolysaccharide. 61
33784501 2021
43
Recurrent pregnancy losses, a lasting cause of infertility. 61
33581853 2021
44
Hydroxysafflor Yellow A Inhibits Staphylococcus aureus-Induced Mouse Endometrial Inflammation via TLR2-Mediated NF-kB and MAPK Pathway. 61
33738649 2021
45
A new and feasible uterine compression suture technique in uterine atony to save mothers from postpartum hemorrhage. 61
33723106 2021
46
Oral antibiotic prophylaxis in elective cesarean deliveries: pilot analysis in tertiary Care Hospital. 61
31113268 2021
47
Birth outcomes in women with body mass index of 40 kg/m2 or greater stratified by planned and actual mode of birth: a systematic review and meta-analysis. 61
32997801 2021
48
Extracellular vesicles in embryo implantation and disorders of the endometrium. 61
33064348 2021
49
Yersinia pseudotuberculosis serotype O:1 infection in a captive Seba's short tailed-fruit bat (Carollia perspicillata) colony in Switzerland. 61
33639950 2021
50
Intraamniotic Infection Rates after Intrauterine Pressure Catheter with and without Amnioinfusion. 61
32791538 2021

Variations for Endometritis

Expression for Endometritis

Search GEO for disease gene expression data for Endometritis.

Pathways for Endometritis

Pathways related to Endometritis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8
2
Show member pathways
12.96 TNF TLR4 IL6 IL1B CXCL8 CXCL1
3
Show member pathways
12.84 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8
4
Show member pathways
12.82 TNF TLR4 IL6 IL1B HLA-DQB1 HLA-DQA1
5 12.81 TNF IL6 IL1B HLA-DQB1 HLA-DQA1
6
Show member pathways
12.75 TNF TLR4 IL6 IL1B CXCL8
7
Show member pathways
12.61 TNF TLR4 IL6 IL1B HLA-DQB1 HLA-DQA1
8
Show member pathways
12.46 TNF TLR4 IL6 IL1B CXCL8
9 12.41 TNF TLR4 IL1B CXCL8
10
Show member pathways
12.37 TNF IL6 IL1B CXCL8 CXCL1
11
Show member pathways
12.36 TNF IL6 CXCL8 CXCL13 CXCL1
12 12.35 TNF IL6 HLA-DQB1 HLA-DQA1
13 12.31 TNF TLR4 SDC1 ESR1
14
Show member pathways
12.31 TNF TLR4 SDC1 IL6 IL1B CXCL8
15
Show member pathways
12.29 TNF TLR4 IL1B HLA-DQB1 HLA-DQA1
16
Show member pathways
12.28 TNF TLR4 IL6 CXCL8
17
Show member pathways
12.24 TNF IL6 IL1B CXCL8
18
Show member pathways
12.22 TNF TLR4 IL1B GLUD1
19 12.2 TNF IL6 IL1B CXCL8
20
Show member pathways
12.19 TNF TLR4 IL6 IL1B CXCL8
21 12.19 TNF TLR4 IL6 IL1B CXCL8 CXCL1
22 12.17 TNF TLR4 IL6 IL1B HLA-DQB1 HLA-DQA1
23 12.08 TNF TLR4 IL6 IL1B CXCL8
24 12.02 TNF IL6 IL1B CXCL8
25 12.01 TNF IL6 IL1B CXCL1
26 11.98 IL6 IL1B CXCL8 CXCL1
27 11.95 TNF IL6 IL1B CXCL8
28 11.93 TNF TLR4 IL1B CXCL8 CXCL1
29
Show member pathways
11.91 TLR4 IL6 CXCL8 CXCL1
30 11.89 TNF IL6 IL1B HLA-DQB1 HLA-DQA1
31 11.88 TNF TLR4 IL6 IL1B CXCL8 CXCL1
32
Show member pathways
11.8 TNF TLR4 IL6 IL1B
33 11.75 TNF IL6 IL1B
34 11.74 TNF TLR4 IL6 IL1B CXCL8 CXCL1
35 11.73 TNF TLR4 IL6 CXCL13
36
Show member pathways
11.69 TNF IL6 IL1B CXCL8
37 11.68 TNF IL6 IL1B CXCL8
38 11.68 TNF TLR4 IL6 IL1B CXCL8
39 11.55 TNF TLR4 IL1B
40 11.54 TNF IL6 HP
41 11.51 TNF IL6 IL1B
42 11.46 TNF IL6 IL1B CXCL8 CXCL1
43 11.42 TNF IL6 IL1B
44 11.39 TNF TLR4 IL6 IL1B CXCL8 CXCL1
45 11.37 TNF TLR4 IL6 IL1B
46 11.35 TNF IL6 IL1B
47 11.33 TNF IL6 IL1B
48 11.24 TNF IL6 IL1B CXCL1
49 11.19 TNF TLR4 IL6 IL1B HLA-DQB1 HLA-DQA1
50 11.16 TNF PGR IL1B

GO Terms for Endometritis

Cellular components related to Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 TNF OXT MIRLET7C MIR27A IL6 IL1B

Biological processes related to Endometritis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.26 TLR4 PGR OXT IL6 IL1B ESR1
2 positive regulation of gene expression GO:0010628 10.08 TNF TLR4 IL6 IL1B CXCL8
3 negative regulation of gene expression GO:0010629 9.97 TNF PGR MIR27A ESR1 CXCL8
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 TNF TLR4 IL6 IL1B
5 positive regulation of JNK cascade GO:0046330 9.86 TNF TLR4 IL1B
6 neutrophil chemotaxis GO:0030593 9.85 CXCL8 CXCL13 CXCL1
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 TNF IL6 IL1B ESR1
8 regulation of insulin secretion GO:0050796 9.83 TNF IL6 IL1B
9 chemokine-mediated signaling pathway GO:0070098 9.83 CXCL8 CXCL13 CXCL1
10 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.83 CXCL8 CXCL13 CXCL1
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF TLR4 IL1B
12 positive regulation of interferon-gamma production GO:0032729 9.81 TNF TLR4 IL1B
13 positive regulation of interleukin-1 beta production GO:0032731 9.8 TNF TLR4 IL6
14 positive regulation of interleukin-6 production GO:0032755 9.8 TNF TLR4 IL6 IL1B
15 cytokine-mediated signaling pathway GO:0019221 9.8 TNF SDC1 IL6 IL1B CXCL8 CXCL1
16 negative regulation of fat cell differentiation GO:0045599 9.79 TNF MIR27A IL6
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 TNF TLR4 IL1B
18 defense response GO:0006952 9.77 TNF HP CXCL8 CXCL13 CXCL1
19 response to glucocorticoid GO:0051384 9.76 TNF SDC1 OXT IL6
20 inflammatory response GO:0006954 9.76 TNF TLR4 SDC1 IL6 IL1B CXCL8
21 positive regulation of chemokine production GO:0032722 9.75 TNF TLR4 IL6
22 positive regulation of interleukin-8 production GO:0032757 9.73 TNF TLR4 IL6 IL1B
23 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF TLR4 IL1B
24 negative regulation of neurogenesis GO:0050768 9.7 TNF IL6 IL1B
25 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 TNF TLR4 IL6
26 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TNF ESR1
27 intracellular steroid hormone receptor signaling pathway GO:0030518 9.67 PGR ESR1
28 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.67 TNF TLR4
29 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
30 positive regulation of prostaglandin secretion GO:0032308 9.65 OXT IL1B
31 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
32 negative regulation of lipid storage GO:0010888 9.64 TNF IL6
33 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.63 MIR27A IL6
34 positive regulation of fever generation GO:0031622 9.61 TNF IL1B
35 immune response GO:0006955 9.61 TNF TLR4 IL6 IL1B HLA-DQB1 HLA-DQA1
36 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
37 positive regulation of neuroinflammatory response GO:0150078 9.58 TNF IL6 IL1B
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 TNF IL1B
39 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
40 cellular response to lipopolysaccharide GO:0071222 9.17 TNF TLR4 IL6 IL1B CXCL8 CXCL13

Molecular functions related to Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CXCL8 CXCL13 CXCL1
2 MHC class II receptor activity GO:0032395 9.26 HLA-DQB1 HLA-DQA1
3 CXCR chemokine receptor binding GO:0045236 9.13 CXCL8 CXCL13 CXCL1
4 cytokine activity GO:0005125 9.1 TNF IL6 IL1B CXCL8 CXCL13 CXCL1

Sources for Endometritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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