MCID: END046
MIFTS: 46

Endometritis

Categories: Reproductive diseases

Aliases & Classifications for Endometritis

MalaCards integrated aliases for Endometritis:

Name: Endometritis 12 54 44 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1002
MeSH 44 D004716
NCIt 50 C26764
SNOMED-CT 67 155975003
UMLS 71 C0014179

Summaries for Endometritis

Disease Ontology : 12 An endometrial disease that is characterized by inflammation of the endometrium.

MalaCards based summary : Endometritis is related to granulomatous endometritis and salpingitis. An important gene associated with Endometritis is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Measles. The drugs Doxycycline and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include uterus, placenta and skin, and related phenotype is neoplasm.

Wikipedia : 74 Endometritis is inflammation of the inner lining of the uterus (endometrium). Symptoms may include... more...

Related Diseases for Endometritis

Diseases in the Endometritis family:

Acute Endometritis

Diseases related to Endometritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 610)
# Related Disease Score Top Affiliating Genes
1 granulomatous endometritis 32.3 SDC1 PGR ESR1
2 salpingitis 31.9 TNF SIGLEC5 IL6
3 chlamydia 31.1 TNF IL6 IL1B CXCL8
4 pelvic inflammatory disease 31.0 SIGLEC5 LACTB HLA-DQB1 HLA-DQA1
5 bacterial vaginosis 30.8 TNF IL6 IL1B CXCL8
6 cervicitis 30.7 TNF IL6 IL1B CXCL8
7 peritonitis 30.5 TNF IL6 IL1B CXCL8 CXCL1
8 chorioamnionitis 30.5 TNF OXT IL6 IL1B CXCL8
9 myoma 30.4 PGR OXT ESR1
10 mastitis 30.4 OXT IL6 HP CXCL8
11 endometriosis 30.3 PGR IL6 IL1B ESR1 CXCL8
12 leiomyoma, uterine 30.3 PGR MIRLET7C MIR27A ESR1
13 toxic shock syndrome 30.3 TNF IL6 IL1B CXCL8
14 vaginal discharge 30.2 TNF PGR OXT IL6 IL1B HP
15 human cytomegalovirus infection 30.2 IL6 IL1B CXCL8
16 thyroiditis 30.2 TNF IL6 IL1B
17 conjunctivitis 30.2 TNF IL6 CXCL8
18 streptococcal toxic-shock syndrome 30.2 TNF IL6 CXCL8
19 bacterial infectious disease 30.1 TNF IL6 IL1B CXCL8
20 cystitis 30.1 TNF IL6 CXCL8 CXCL1
21 q fever 30.1 TNF IL6 IL1B
22 bacteriuria 30.1 IL6 CXCL8 CXCL1
23 haemophilus influenzae 30.1 TNF LACTB CXCL8
24 cellulitis 30.1 TNF LACTB IL6
25 adenomyosis 30.0 PGR OXT IL6 ESR1 CXCL8
26 trichomoniasis 30.0 TNF IL6 IL1B CXCL8
27 urethritis 30.0 TNF IL6 IL1B CXCL8
28 measles 30.0 TNF IL6 IL1B HLA-DQA1
29 acute cystitis 30.0 TNF IL6 IL1B CXCL8 CXCL1
30 acute gonococcal cervicitis 29.9 IL6 CXCL8
31 pulmonary tuberculosis 29.8 TNF IL6 HP HLA-DQB1
32 diverticulitis 29.8 TNF SDC1 IL6
33 leptospirosis 29.8 TNF IL6 IL1B CXCL8
34 pre-eclampsia 29.8 TNF OXT IL6 IL1B CXCL8
35 appendicitis 29.8 TNF IL6 IL1B CXCL8
36 exanthem 29.8 TNF IL6 IL1B CXCL8
37 stomatitis 29.8 TNF IL6 IL1B CXCL8
38 pyelonephritis 29.8 TNF IL6 IL1B CXCL8
39 candidiasis 29.7 TNF IL6 IL1B CXCL8
40 meningitis 29.7 TNF LACTB IL6 IL1B CXCL8 CXCL1
41 ovarian disease 29.7 TNF PGR MIR27A IL6 ESR1
42 vaginitis 29.7 TNF SIGLEC5 IL6 IL1B ESR1 CXCL8
43 pyometritis 29.7 PGR HP
44 viral infectious disease 29.7 TNF IL6 IL1B CXCL8
45 endocarditis 29.7 TNF LACTB IL6 CXCL8
46 adult respiratory distress syndrome 29.6 TNF IL6 IL1B CXCL8 CXCL1
47 immune deficiency disease 29.5 TNF SIGLEC5 IL6 IL1B HLA-DQB1 CXCL1
48 pulmonary disease, chronic obstructive 29.4 TNF SIGLEC5 IL6 IL1B CXCL8
49 reactive arthritis 29.4 TNF IL6 IL1B HP CXCL8
50 tonsillitis 29.4 TNF LACTB IL6 IL1B CXCL8 CXCL1

Graphical network of the top 20 diseases related to Endometritis:



Diseases related to Endometritis

Symptoms & Phenotypes for Endometritis

MGI Mouse Phenotypes related to Endometritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 ESR1 HP IL1B IL6 PGR SDC1

Drugs & Therapeutics for Endometritis

Drugs for Endometritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4 Antiparasitic Agents Phase 4
5 Antiprotozoal Agents Phase 4
6 Antimalarials Phase 4
7 Plasma Substitutes Phase 4
8 Blood Substitutes Phase 4
9 Lactams Phase 4
10 beta-Lactams Phase 4
11 Gentamicins Phase 4
12 Antitubercular Agents Phase 4
13 Clindamycin palmitate Phase 4
14 Clindamycin phosphate Phase 4
15
Ampicillin Approved, Vet_approved Phase 2, Phase 3 69-53-4 6249
16
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
17
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
18
Metronidazole Approved Phase 2 443-48-1 4173
19
Chlorhexidine Approved, Vet_approved Phase 1, Phase 2 55-56-1 9552079 2713
20
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
21
Cefoxitin Approved Phase 2 35607-66-0 441199
22
Ofloxacin Approved Phase 2 82419-36-1 4583
23
Levofloxacin Approved, Investigational Phase 2 100986-85-4 149096
24 Pharmaceutical Solutions Phase 1, Phase 2
25 Chlorhexidine gluconate Phase 1, Phase 2
26 Disinfectants Phase 1, Phase 2
27 Dermatologic Agents Phase 1, Phase 2
28
Ertapenem Approved, Investigational Phase 1 153832-46-3 150610
29
Clavulanate Approved, Vet_approved 58001-44-8 5280980
30
Tinidazole Approved, Investigational 19387-91-8 5479
31
Methylergonovine Approved 113-42-8 8226
32
Curcumin Approved, Experimental, Investigational 458-37-7 969516
33
Oxytocin Approved, Vet_approved 50-56-6 439302 53477758
34
Povidone-iodine Approved 25655-41-8
35
Iodine Approved, Investigational 7553-56-2 807
36
Povidone Approved 9003-39-8 131751496
37
Progesterone Approved, Vet_approved 57-83-0 5994
38
Cadexomer iodine Experimental 94820-09-4
39 Amoxicillin-Potassium Clavulanate Combination
40 beta-Lactamase Inhibitors
41 Cytochrome P-450 Enzyme Inhibitors
42 Alkylating Agents
43 Calamus
44 Analgesics, Non-Narcotic
45 Anti-Inflammatory Agents
46 Anti-Inflammatory Agents, Non-Steroidal
47 Analgesics
48 Antirheumatic Agents
49 Acidophilus
50 Anti-Infective Agents, Local

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Preoperative Vaginal Cleansing With Povidone Iodine and the Risk of Post Cesarean Endometritis Unknown status NCT02693483 Phase 4 10% povidone iodine
2 SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle Completed NCT01242852 Phase 4
3 Does Preoperative Vaginal Preparation With Povidone-iodine Before Cesarean Delivery Reduce the Risk of Endometritis? Completed NCT01437228 Phase 4 povidone- iodine solution.;placebo
4 Efficacy and Side-Effects of Two Dosing Regimens of Doxycycline at Surgical Abortion: A Randomized Double-Blind Trial Completed NCT00547170 Phase 4 Doxycycline pre-operatively;Doxycycline post-operatively
5 Antibiotics During Intrauterine Balloon Tamponade Placement Recruiting NCT03478163 Phase 4 CeFAZolin 1000 MG;Clindamycin 900 MG in 6 ML Injection
6 Azithromycin With or Without Amoxicillin to Prevent Peripartum Infection and Sepsis in Laboring High-risk Women: 3-Arm RCT Recruiting NCT03248297 Phase 4 Azithromycin;Azithromycin and amoxicillin;Placebo
7 Treatment Utility of Postpartum Antibiotics in Chorioamnionitis Terminated NCT01585129 Phase 4 Postpartum Antibiotics;No postpartum antibiotics
8 Antibiotic Prophylaxis and Intervention for Postpartum Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
9 A Randomized Clinical Trial of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis Withdrawn NCT01721616 Phase 4 Azithromycin;Cefazolin
10 Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term - a Randomized Controlled Trial Completed NCT01633294 Phase 2, Phase 3 Ampicillin + gentamicin
11 The Optimal Time for Intravenous Antibiotic Prophylaxis in Elective Cesarean Section: Randomized Comparative Study Unknown status NCT02742948 Phase 2 ceftriaxone
12 Introducing Intrauterine Antibiotic Infusion as a Novel Approach in Effectively Treating Chronic Endometritis and Restoring Reproductive Dynamics: A Pilot Study Completed NCT04447625 Phase 2 Oral antibiotic administration;Intrauterine antibiotic infusion
13 The Impact of Chlorhexidine Preoperative Vaginal Preparation in Reducing the Post-cesarean Endometritis and Sepsis for Cases in Labor. A Randomized Controlled Trial Recruiting NCT04385680 Phase 1, Phase 2 Chlorhexidine Gluconate vaginal solution 0.05%
14 Azithromycin-based Extended-spectrum Prophylaxis in Scheduled Cesarean Deliveries Recruiting NCT03960970 Phase 2 Azithromycin 500 mg;Mefoxin 2g
15 Fertility Restoration Using Autologous Adipose Tissue Derived Mesenchymal Stem Cells Enrolling by invitation NCT04432467 Phase 1, Phase 2
16 Comparative Controlled Trial of Treatment of Minor Unexpected Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy Screening in Women Indicated for IVF Terminated NCT00830401 Phase 2 Ofloxacinum/Doxycycline
17 Pharmacokinetics and Safety of Ertapenem in the Postpartum Period Terminated NCT01587495 Phase 1 Ertapenem
18 Vaginal Antimicrobacterial Preparation Before Cesarean Secation for Endometritis Prevention Unknown status NCT03093194
19 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth Unknown status NCT01945450 Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
20 The Effect of Placenta Removal Method On Postpartum Leucocytosis : A Randomized Controlled Trial Completed NCT04323241
21 Prevalence of Chronic Endometritis in Severe Intrauterine Adhesions and Role of Chronic Endometritis in Postoperative Recurrence of Severe Intrauterine Completed NCT02744807
22 Antibiotic Prophylaxis in Ragged Placental Membranes: A Prospective, Multicenter, Randomized Trial Completed NCT03459599 Prophylactic antibiotics
23 The Impact of Chronic Endometritis on IVF Pregnancy and Pregnancy Loss Rates Completed NCT02646930
24 Characterization of Novel Organisms in the Genital Tract of Women With PID and Determination of Their Association With Endometritis. Completed NCT01236131
25 Prevalence of Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization Completed NCT01762098
26 A Prospective, Randomized,Controlled Trial on the Effect of Antibiotic Therapy on Endometrial Response in Women With Chronic Endometritis Completed NCT02648698 Antibiotics
27 Efficacy of Intravaginal Dead Sea Peloid Gel Administration in Complex Treatment of Chronic Endometritis and Reproductive Disorders: Randomized Placebo-controlled Prospective Study Completed NCT02680275 Dead Sea Peloid Gel
28 Supplemental Perioperative Oxygen to Reduce the Incidence of Post-Cesarean Endometritis and Wound Infection Completed NCT00670020
29 Reduction of Endometritis After Cesarean Section With the Routine Use of Methergine Completed NCT00858832 Methergine
30 The Pharmacokinetics of Azithromycin Prophylaxis for Cesarean Delivery Completed NCT01464840 Azithromycin
31 A Randomized, Double-Blind, Placebo Controlled Trial of Cefazolin Given Either 30 Minutes Prior to Cesarean Section or at Cord Clamping Completed NCT00330278 Cefazolin
32 Cesarean Section Optimal Antibiotic Prophylaxis Trial Completed NCT01235546 Azithromycin and standard of care;Placebo and standard of care
33 Uterine Flora During Elective and Urgent Cesarean Sections and Its Relationship to Postpartum Complications. Completed NCT00500019
34 Use fo Antiseptic Solution for Vaginal Wash Before Cesarean Section in Patients With Premature Rupture of Membranes. A Randomized, Double Blind, Controlled Trial. Completed NCT03442218 Clorhexidine;Saline solution
35 Controlled Clinical Trial of Supplemental Oxygen for the Prevention of Post-Cesarean Infectious Morbidity Completed NCT00603603
36 A Randomized Trial to Determine if a Pre-operative Wash With a Chlorhexidine Cloth Reduces Infectious Morbidity in Patients Undergoing Cesarean Section Completed NCT02402907
37 A Prospective Comparative Study of Induction of Labor With a Cervical Ripening Double Balloon vs Foley Catheter Completed NCT00501033
38 Mid-Infrared Spectroscopy as a Real Time Diagnostic Tool for Chronic Endometritis Recruiting NCT04197167
39 Curcumin Supplementation for Gynecological Diseases Including Pelvic Inflammatory Disease Endometritis, Endometriosis: A Pilot Study Recruiting NCT03016039
40 Combining Vaginal Preparation and Azithromycin in Reduction of Post Cesarean Infections: A Randomized Controlled Trial Recruiting NCT04163679
41 Vaginal Cleansing Before Cesarean Delivery to Reduce Infection: A Randomized Trial Active, not recruiting NCT02495753
42 Difference in Relative Abundance of Lactobacillus in Endometrium With and Without Histologically Proven Chronic Endometritis Not yet recruiting NCT04103242
43 Comparison Between Two Protocols for Management of Prelabor Rupture of the Membranes at Term Not yet recruiting NCT04307069 Oxytocin
44 Incidence and Risk Factors for Secondary Severe Postpartum Hemorrhage in the General Population Not yet recruiting NCT03840889
45 Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments Terminated NCT03169621
46 Vaginal Cleansing at Cesarean Delivery to Reduce Infection: A Randomized, Controlled Trial Terminated NCT00386477

Search NIH Clinical Center for Endometritis

Cochrane evidence based reviews: endometritis

Genetic Tests for Endometritis

Anatomical Context for Endometritis

MalaCards organs/tissues related to Endometritis:

40
Uterus, Placenta, Skin, Neutrophil, Cervix, Fetal Lung, Breast

Publications for Endometritis

Articles related to Endometritis:

(show top 50) (show all 3846)
# Title Authors PMID Year
1
Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility. 61 54
19933542 2009
2
WITHDRAWN: Oxytocin for prelabour rupture of membranes at or near term. 54 61
17636608 2007
3
Oxytocin for prelabour rupture of membranes at or near term. 61 54
10796159 2000
4
Premature rupture of membranes at term: a meta-analysis of three management schemes. 54 61
9170488 1997
5
Clinical amnionitis and endometritis in patients with premature rupture of membranes: endocervical prostaglandin E2 gel versus oxytocin for induction of labor. 54 61
8841214 1996
6
Oxytocin enhances clearance of radiocolloid from the uterine lumen of reproductively normal mares and mares susceptible to endometritis. 54 61
8575394 1994
7
Investigations into the use of exogenous oxytocin for promoting uterine drainage in mares susceptible to endometritis. 54 61
1897091 1991
8
Oral antibiotic prophylaxis in elective cesarean deliveries: pilot analysis in tertiary Care Hospital. 61
31113268 2021
9
The effect of vaginal disinfection on reducing post-caesarean endometritis: A prospective, randomised controlled trial. 61
33186774 2021
10
The effects of chronic endometritis on the pregnancy outcomes. 61
33020952 2021
11
Intrauterine infusion of killed semen adversely affects uterine blood flow and endometrial gene expression of inflammatory cytokines in mares susceptible to persistent breeding-induced endometritis. 61
33493874 2021
12
Alteration in endometrial helper T-cell subgroups in chronic endometritis. 61
33155317 2021
13
Day 7 embryo quality and suboptimal uterine environment influence morphometry of Day 16 conceptus in dairy cows. 61
33485025 2021
14
Alterations in the relative abundance of the vasoactive intestinal peptide receptors (VPAC1 and VPAC2) and functions in uterine contractility during inflammation. 61
33388613 2021
15
New approach to the risk variables for administration of fibrinogen in patients with postpartum hemorrhage by using cluster analysis. 61
32967036 2021
16
Prostaglandins and cesarean delivery for nonreassuring fetal status in patients delivering small-for-gestational age neonates at term. 61
30983445 2021
17
Stepwise implementation of vaginal cleansing and azithromycin at cesarean: a quality improvement study. 61
33525938 2021
18
Recurrent pregnancy losses, a lasting cause of infertility. 61
33581853 2021
19
Quantifying CD138+ cells in the endometrium to assess chronic endometritis in women at risk of recurrent pregnancy loss: A prospective cohort study and rapid review. 61
33274569 2021
20
Impact of antibiotic therapy on the rate of negative test results for chronic endometritis: a prospective randomized control trial. 61
33549312 2021
21
IFN-τ Attenuates LPS-Induced Endometritis by Restraining HMGB1/NF-κB Activation in bEECs. 61
33604776 2021
22
Maternal Sepsis: Presentation, Course, Treatment, and Outcomes. 61
33587343 2021
23
Intraamniotic Infection Rates after Intrauterine Pressure Catheter with and without Amnioinfusion. 61
32791538 2021
24
Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis. 61
33581856 2021
25
Birth outcomes in women with body mass index of 40 kg/m2 or greater stratified by planned and actual mode of birth: a systematic review and meta-analysis. 61
32997801 2021
26
Extracellular vesicles in embryo implantation and disorders of the endometrium. 61
33064348 2021
27
Effects of metritis treatment strategies on health, behavior, reproductive, and productive responses of Holstein cows. 61
33309374 2021
28
Prediction of Calving to Conception Interval Length Using Algorithmic Analysis of Endometrial mRNA Expression in Bovine. 61
33478124 2021
29
Andrographolide attenuates inflammatory response induced by LPS via activating Nrf2 signaling pathway in bovine endometrial epithelial cells. 61
33290978 2021
30
Maternal Outcomes of Ongoing Pregnancies Complicated by Fetal Life-Limiting Conditions. 61
32645723 2021
31
Definition, diagnostic and therapeutic options in recurrent implantation failure: an international survey of clinicians and embryologists. 61
33313697 2021
32
The contraceptive efficacy of a self-assembling intra-uterine device in domestic mares. 61
33462802 2021
33
Trueperella pyogenes pyolysin inhibits lipopolysaccharide-induced inflammatory response in endometrium stromal cells via autophagy- and ATF6-dependent mechanism. 61
33454924 2021
34
Heat shock protein HSP90 immunoexpression in equine endometrium during oestrus, dioestrus and anoestrus. 61
32776605 2021
35
DNaseI protects lipopolysaccharide-induced endometritis in mice by inhibiting neutrophil extracellular traps formation. 61
33309847 2021
36
Analysis of the therapeutic effects of hysteroscopic polypectomy with and without doxycycline treatment on chronic endometritis with endometrial polyps. 61
33501741 2021
37
Single-unit vs multiple-unit transfusion in hemodynamically stable postpartum anemia: a pragmatic randomized controlled trial. 61
32652065 2021
38
Foley Bulb Insertion by Blind Placement Compared With Direct Visualization: A Randomized Controlled Trial. 61
33278290 2021
39
Outcomes of Expectant Management of Term Prelabor Rupture of Membranes. 61
33493463 2021
40
Dexamethasone vs. betamethasone for preterm birth: a systematic review and network meta-analysis. 61
33482400 2021
41
The effectiveness of using a molded sorbent: Modified polyvinylpyrrolidone for the combined treatment of chronic endometritis. 61
33471361 2021
42
Effects of Intrauterine Infusion of a Chitosan Solution on Recovery and Subsequent Reproductive Performance of Early Postpartum Dairy Cows with Endometritis: A Pilot Field Trial. 61
33467578 2021
43
Importance of broth-enrichment culture in equine endometritis diagnosis. 61
33582824 2021
44
Risk factors associated with endometritis in zero-grazed dairy cows on smallholder farms in Rwanda. 61
33454513 2021
45
Postpartum endometritis after uterine cleaning versus no cleaning in cesarean sections: Randomized clinical trial. 61
33438313 2021
46
Outcome study of five cases receiving in vitro fertilization after treatment of intrauterine platelet-rich plasma (PRP) for chronic endometritis. 61
33470585 2021
47
Normal and abnormal response to sperm deposition in female dogs: A review and new hypotheses for endometritis. 61
33160112 2021
48
Characterization of intrauterine cultivable aerobic microbiota at the time of insemination in dairy cows with and without mild endometritis. 61
33113441 2021
49
Multiple endometrial polyps is associated with higher risk of chronic endometritis in reproductive-aged women. 61
33300233 2021
50
Clinical efficacy of intravaginal recombinant lysostaphin administration on endometritis in sows. 61
33389826 2021

Variations for Endometritis

Expression for Endometritis

Search GEO for disease gene expression data for Endometritis.

Pathways for Endometritis

Pathways related to Endometritis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8
2
Show member pathways
12.81 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8
3 12.79 TNF IL6 IL1B HLA-DQB1 HLA-DQA1
4
Show member pathways
12.74 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8
5
Show member pathways
12.59 TNF IL6 IL1B HLA-DQB1 HLA-DQA1
6 12.32 TNF IL6 HLA-DQB1 HLA-DQA1
7
Show member pathways
12.3 TNF SDC1 IL6 IL1B CXCL8
8
Show member pathways
12.3 TNF IL6 IL1B CXCL8 CXCL1
9
Show member pathways
12.29 TNF IL6 CXCL8 CXCL13 CXCL1
10
Show member pathways
12.25 TNF IL1B HLA-DQB1 HLA-DQA1
11
Show member pathways
12.19 TNF IL6 IL1B CXCL8
12 12.18 TNF IL6 IL1B CXCL8 CXCL1
13 12.17 TNF IL6 IL1B CXCL8
14 12.16 TNF IL6 IL1B HLA-DQB1 HLA-DQA1
15 12.09 TNF IL6 IL1B CXCL8
16 11.98 TNF IL6 IL1B CXCL8
17 11.96 TNF IL6 IL1B CXCL1
18 11.92 IL6 IL1B CXCL8 CXCL1
19 11.91 TNF IL1B CXCL8 CXCL1
20 11.91 TNF IL6 IL1B CXCL8 CXCL1
21 11.88 TNF IL6 IL1B CXCL8
22 11.81 TNF IL6 IL1B CXCL8 CXCL1
23 11.76 TNF IL6 IL1B HLA-DQB1 HLA-DQA1
24
Show member pathways
11.74 TNF IL6 IL1B
25 11.73 TNF IL6 IL1B
26 11.72 TNF IL6 IL1B CXCL8
27 11.67 TNF IL6 CXCL13
28
Show member pathways
11.6 TNF IL6 IL1B CXCL8
29 11.58 TNF IL6 IL1B CXCL8
30 11.52 TNF IL6 HP
31 11.49 TNF IL6 IL1B
32 11.41 TNF IL6 IL1B CXCL8 CXCL1
33 11.39 TNF IL6 IL1B
34 11.36 TNF IL6 IL1B
35 11.31 TNF IL6 IL1B
36 11.3 TNF IL6 IL1B
37 11.25 TNF SDC1 IL6 IL1B CXCL8
38 11.14 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8
39 11.09 TNF PGR IL1B
40 11.09 TNF IL6 IL1B CXCL1
41 11.04 TNF IL6 IL1B CXCL8 CXCL1
42 11.02 TNF IL6 IL1B CXCL8 CXCL13 CXCL1
43 11 TNF IL6 CXCL8

GO Terms for Endometritis

Cellular components related to Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 TNF OXT MIRLET7C MIR27A IL6 IL1B

Biological processes related to Endometritis according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.85 TNF PGR MIR27A MIR124-1 ESR1 CXCL8
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 TNF IL6 IL1B ESR1
3 neutrophil chemotaxis GO:0030593 9.8 CXCL8 CXCL13 CXCL1
4 defense response GO:0006952 9.8 TNF HP CXCL8 CXCL13 CXCL1
5 cytokine-mediated signaling pathway GO:0019221 9.8 TNF SDC1 IL6 IL1B CXCL8 CXCL1
6 regulation of insulin secretion GO:0050796 9.79 TNF IL6 IL1B
7 chemokine-mediated signaling pathway GO:0070098 9.78 CXCL8 CXCL13 CXCL1
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.77 CXCL8 CXCL13 CXCL1
9 response to glucocorticoid GO:0051384 9.76 TNF SDC1 OXT IL6
10 positive regulation of interleukin-8 production GO:0032757 9.74 TNF IL6 IL1B
11 negative regulation of fat cell differentiation GO:0045599 9.73 TNF MIR27A IL6
12 inflammatory response GO:0006954 9.7 TNF SDC1 IL6 IL1B CXCL8 CXCL13
13 negative regulation of neurogenesis GO:0050768 9.67 TNF IL6 IL1B
14 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL6 IL1B
15 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.63 TNF ESR1
16 intracellular steroid hormone receptor signaling pathway GO:0030518 9.63 PGR ESR1
17 regulation of establishment of endothelial barrier GO:1903140 9.62 TNF IL1B
18 positive regulation of neuroinflammatory response GO:0150078 9.61 TNF IL6 IL1B
19 positive regulation of prostaglandin secretion GO:0032308 9.59 OXT IL1B
20 negative regulation of lipid storage GO:0010888 9.58 TNF IL6
21 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.58 MIR27A IL6
22 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
23 sequestering of triglyceride GO:0030730 9.54 TNF IL1B
24 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IL1B
25 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
26 cellular response to lipopolysaccharide GO:0071222 9.43 TNF IL6 IL1B CXCL8 CXCL13 CXCL1
27 immune response GO:0006955 9.23 TNF IL6 IL1B HLA-DQB1 HLA-DQA1 CXCL8

Molecular functions related to Endometritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.33 CXCL8 CXCL13 CXCL1
2 MHC class II receptor activity GO:0032395 9.26 HLA-DQB1 HLA-DQA1
3 CXCR chemokine receptor binding GO:0045236 9.13 CXCL8 CXCL13 CXCL1
4 cytokine activity GO:0005125 9.1 TNF IL6 IL1B CXCL8 CXCL13 CXCL1

Sources for Endometritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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