MCID: END018
MIFTS: 29

Endometrium Carcinoma in Situ

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrium Carcinoma in Situ

MalaCards integrated aliases for Endometrium Carcinoma in Situ:

Name: Endometrium Carcinoma in Situ 12 15
Carcinoma in Situ of Endometrium 12
Endometrial Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5172
SNOMED-CT 67 189343006
ICD10 32 D07.0
UMLS 70 C0346191

Summaries for Endometrium Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the endometrium.

MalaCards based summary : Endometrium Carcinoma in Situ, also known as carcinoma in situ of endometrium, is related to endometrial cancer and in situ carcinoma. An important gene associated with Endometrium Carcinoma in Situ is NME1-NME2 (NME1-NME2 Readthrough), and among its related pathways/superpathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Affiliated tissues include endometrium and cervix.

Related Diseases for Endometrium Carcinoma in Situ

Diseases related to Endometrium Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 endometrial cancer 10.3
2 in situ carcinoma 10.1
3 endometrial adenocarcinoma 10.0
4 papillary carcinoma 10.0
5 carcinosarcoma 10.0
6 nemaline myopathy 2 9.9 NME2 NME1-NME2
7 hemangioblastoma 9.7 PAX2 KRT8
8 oncocytoma 9.6 PAX2 KRT8

Graphical network of the top 20 diseases related to Endometrium Carcinoma in Situ:



Diseases related to Endometrium Carcinoma in Situ

Symptoms & Phenotypes for Endometrium Carcinoma in Situ

Drugs & Therapeutics for Endometrium Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Endometrium Carcinoma in Situ

Genetic Tests for Endometrium Carcinoma in Situ

Anatomical Context for Endometrium Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrium Carcinoma in Situ:

19
Endometrium

MalaCards organs/tissues related to Endometrium Carcinoma in Situ:

40
Cervix

Publications for Endometrium Carcinoma in Situ

Articles related to Endometrium Carcinoma in Situ:

(show all 11)
# Title Authors PMID Year
1
Clear Cell Endometrial Carcinoma In Situ (CCEIC) Exists! 61
31416376 2020
2
Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer. 61
21363919 2011
3
Local immune response in serous papillary carcinoma of the endometrium. 61
15736043 2005
4
[Endometrial carcinoma in situ. Morphological and immunohistochemical aspects]. 61
14756081 2003
5
p53 immunostaining as a significant adjunct diagnostic method for uterine surface carcinoma: precursor of uterine papillary serous carcinoma. 61
9850172 1998
6
[Endometrial hyperplasia and carcinoma in situ]. 61
9618961 1997
7
Endometrial carcinoma in situ in postmenopausal women. 61
7694943 1995
8
3-D reconstruction of endometrial carcinoma in situ. 61
3766463 1986
9
Risk factors for adenomatous endometrial hyperplasia: a case-control study. 61
3946378 1986
10
Endometrial abnormalities occurring in young women on long-term sequential oral contraception. 61
934552 1976
11
Diagnosis of endometrial carcinoma in situ by suction dilation of the cervix uteri. 61
13822991 1959

Variations for Endometrium Carcinoma in Situ

Cosmic variations for Endometrium Carcinoma in Situ:

9 (show top 50) (show all 298)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM143461500 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.-65C>A p.? 17:7675199-7675199 9
2 COSM142559914 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.407G>A p.R136H 17:7675088-7675088 9
3 COSM144013113 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.491G>A p.R164H 17:7675088-7675088 9
4 COSM144307878 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.380C>A p.A127D 17:7675199-7675199 9
5 COSM122733880 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.128G>A p.R43H 17:7675088-7675088 9
6 COSM112253124 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.524G>A p.R175H 17:7675088-7675088 9
7 COSM144309944 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.407G>A p.R136H 17:7675088-7675088 9
8 COSM144239400 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.-65C>A p.? 17:7675199-7675199 9
9 COSM122734408 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.421C>T p.R141C 17:7673803-7673803 9
10 COSM144310445 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.700C>T p.R234C 17:7673803-7673803 9
11 COSM105980217 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 9
12 COSM105619860 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.524G>A p.R175H 17:7675088-7675088 9
13 COSM143156608 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.47G>A p.R16H 17:7675088-7675088 9
14 COSM145017326 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.407G>A p.R136H 17:7675088-7675088 9
15 COSM122271832 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.421C>T p.R141C 17:7673803-7673803 9
16 COSM144651456 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.700C>T p.R234C 17:7673803-7673803 9
17 COSM93515916 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 9
18 COSM143943565 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.47G>A p.R16H 17:7675088-7675088 9
19 COSM144367945 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.-65C>A p.? 17:7675199-7675199 9
20 COSM112253896 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 9
21 COSM106401970 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 9
22 COSM112096115 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 9
23 COSM143697842 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.296C>A p.A99D 17:7675199-7675199 9
24 COSM142885348 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.296C>A p.A99D 17:7675199-7675199 9
25 COSM144013689 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.784C>T p.R262C 17:7673803-7673803 9
26 COSM93184014 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 9
27 COSM143370595 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.407G>A p.R136H 17:7675088-7675088 9
28 COSM122235967 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.17C>A p.A6D 17:7675199-7675199 9
29 COSM144087282 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.340C>T p.R114C 17:7673803-7673803 9
30 COSM106053452 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 9
31 COSM122271291 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.128G>A p.R43H 17:7675088-7675088 9
32 COSM145021476 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.296C>A p.A99D 17:7675199-7675199 9
33 COSM144650780 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.407G>A p.R136H 17:7675088-7675088 9
34 COSM143159658 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 9
35 COSM111758883 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 9
36 COSM144627327 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.296C>A p.A99D 17:7675199-7675199 9
37 COSM143371158 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.700C>T p.R234C 17:7673803-7673803 9
38 COSM111758247 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.524G>A p.R175H 17:7675088-7675088 9
39 COSM121876485 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.421C>T p.R141C 17:7673803-7673803 9
40 COSM145017959 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.700C>T p.R234C 17:7673803-7673803 9
41 COSM87898723 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 9
42 COSM122646456 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.17C>A p.A6D 17:7675199-7675199 9
43 COSM88306971 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 9
44 COSM142837563 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 9
45 COSM142560569 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.700C>T p.R234C 17:7673803-7673803 9
46 COSM123086852 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.17C>A p.A6D 17:7675199-7675199 9
47 COSM144086975 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.47G>A p.R16H 17:7675088-7675088 9
48 COSM143157028 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.340C>T p.R114C 17:7673803-7673803 9
49 COSM93183307 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.524G>A p.R175H 17:7675088-7675088 9
50 COSM121875575 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.128G>A p.R43H 17:7675088-7675088 9

Expression for Endometrium Carcinoma in Situ

Search GEO for disease gene expression data for Endometrium Carcinoma in Situ.

Pathways for Endometrium Carcinoma in Situ

GO Terms for Endometrium Carcinoma in Situ

Cellular components related to Endometrium Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 NME2 KRT8

Biological processes related to Endometrium Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.58 NME2 NME1-NME2 AMHR2
2 cellular response to glucose stimulus GO:0071333 9.37 PAX2 NME2
3 positive regulation of epithelial cell proliferation GO:0050679 9.32 PAX2 NME2
4 nucleoside diphosphate phosphorylation GO:0006165 9.26 NME2 NME1-NME2
5 CTP biosynthetic process GO:0006241 9.16 NME2 NME1-NME2
6 GTP biosynthetic process GO:0006183 8.96 NME2 NME1-NME2
7 UTP biosynthetic process GO:0006228 8.62 NME2 NME1-NME2

Molecular functions related to Endometrium Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.13 NME2 NME1-NME2 AMHR2
2 nucleoside diphosphate kinase activity GO:0004550 8.62 NME2 NME1-NME2

Sources for Endometrium Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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