MCID: END018
MIFTS: 19

Endometrium Carcinoma in Situ

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Endometrium Carcinoma in Situ

MalaCards integrated aliases for Endometrium Carcinoma in Situ:

Name: Endometrium Carcinoma in Situ 12 15
Carcinoma in Situ of Endometrium 12
Endometrial Carcinoma in Situ 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5172
SNOMED-CT 69 92582009
ICD10 34 D07.0
UMLS 74 C0346191

Summaries for Endometrium Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the endometrium.

MalaCards based summary : Endometrium Carcinoma in Situ, also known as carcinoma in situ of endometrium, is related to in situ carcinoma and endometrial cancer. An important gene associated with Endometrium Carcinoma in Situ is PGR (Progesterone Receptor), and among its related pathways/superpathways is Gastric cancer. Affiliated tissues include the endometrium.

Related Diseases for Endometrium Carcinoma in Situ

Diseases related to Endometrium Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 29.8 PGR TP53
2 endometrial cancer 29.3 PGR TP53
3 adenocarcinoma 9.9
4 breast malignant phyllodes tumor 9.9 PGR TP53
5 olfactory groove meningioma 9.9 PGR TP53
6 synchronous bilateral breast carcinoma 9.9 PGR TP53
7 papillary serous adenocarcinoma 9.9 PGR TP53
8 uterine body mixed cancer 9.9 PGR TP53
9 bartholin's gland disease 9.9 PGR TP53
10 female reproductive endometrioid cancer 9.9 PGR TP53
11 cervical carcinosarcoma 9.9 PGR TP53
12 carcinosarcoma 9.9 PGR TP53
13 glycogen-rich clear cell breast carcinoma 9.9 PGR TP53
14 microglandular adenosis 9.9 PGR TP53
15 anterior cranial fossa meningioma 9.9 PGR TP53
16 adenosarcoma 9.9 PGR TP53
17 breast benign neoplasm 9.9 PGR TP53
18 thoracic benign neoplasm 9.9 PGR TP53
19 uterine corpus cancer 9.9 PGR TP53
20 mixed cell type cancer 9.9 PGR TP53
21 primary peritoneal carcinoma 9.9 PGR TP53
22 pre-malignant neoplasm 9.9 PGR TP53
23 fallopian tube carcinoma 9.9 PGR TP53
24 papillary adenocarcinoma 9.9 PGR TP53
25 muscle cancer 9.9 PGR TP53
26 breast carcinoma in situ 9.9 PGR TP53
27 malignant ovarian surface epithelial-stromal neoplasm 9.9 PGR TP53
28 ovary epithelial cancer 9.9 PGR TP53
29 female breast cancer 9.9 PGR TP53
30 serous cystadenocarcinoma 9.9 PGR TP53
31 cystadenocarcinoma 9.9 PGR TP53
32 cervical adenocarcinoma 9.9 PGR TP53
33 estrogen-receptor positive breast cancer 9.9 PGR TP53
34 sweat gland cancer 9.9 PGR TP53
35 uterine anomalies 9.9 PGR TP53
36 sporadic breast cancer 9.9 PGR TP53
37 ductal carcinoma in situ 9.9 PGR TP53
38 ovarian serous cystadenocarcinoma 9.8 PGR TP53
39 leiomyosarcoma 9.8 PGR TP53
40 female reproductive system disease 9.8 PGR TP53
41 reproductive system disease 9.8 PGR TP53
42 endometrial adenocarcinoma 9.8 PGR TP53
43 uterine carcinosarcoma 9.8 PGR TP53
44 breast ductal carcinoma 9.8 PGR TP53
45 endometrial stromal sarcoma 9.8 PGR TP53
46 meningioma, familial 9.8 PGR TP53
47 ovarian disease 9.8 PGR TP53
48 breast disease 9.7 PGR TP53
49 adamantinoma of long bones 9.7 PGR TP53
50 adenoid cystic carcinoma 9.7 PGR TP53

Graphical network of the top 20 diseases related to Endometrium Carcinoma in Situ:



Diseases related to Endometrium Carcinoma in Situ

Symptoms & Phenotypes for Endometrium Carcinoma in Situ

Drugs & Therapeutics for Endometrium Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Endometrium Carcinoma in Situ

Genetic Tests for Endometrium Carcinoma in Situ

Anatomical Context for Endometrium Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Endometrium Carcinoma in Situ:

20
The Endometrium

Publications for Endometrium Carcinoma in Situ

Articles related to Endometrium Carcinoma in Situ:

# Title Authors Year
1
Adenocarcinoma (gland-cell carcinoma) in situ of endometrium. ( 7145768 )
1982

Variations for Endometrium Carcinoma in Situ

Cosmic variations for Endometrium Carcinoma in Situ:

9 (show top 50) (show all 71)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10659 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.817C>T p.R273C 17:7673803-7673803 0
2 COSM5346978 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.413C>A p.A138D 17:7675199-7675199 0
3 COSM10648 TP53 endometrium,NS,carcinoma,undifferentiated carcinoma c.524G>A p.R175H 17:7675088-7675088 0
4 COSM6954416 SMARCA4 endometrium,NS,carcinoma,undifferentiated carcinoma c.1867G>A p.E623K 19:11003083-11003083 0
5 COSM3981624 SMAD3 endometrium,NS,carcinoma,undifferentiated carcinoma c.277C>T p.R93* 15:67164965-67164965 0
6 COSM6952416 RBM10 endometrium,NS,carcinoma,undifferentiated carcinoma c.520G>A p.A174T 23:47175036-47175036 0
7 COSM33000 RBM10 endometrium,NS,carcinoma,undifferentiated carcinoma c.1187G>A p.R396H 23:47180445-47180445 0
8 COSM29529 RB1 endometrium,NS,carcinoma,undifferentiated carcinoma c.1411C>T p.Q471* 13:48380074-48380074 0
9 COSM23824 RB1 endometrium,NS,carcinoma,undifferentiated carcinoma c.2359C>T p.R787* 13:48465238-48465238 0
10 COSM935281 PTPN11 endometrium,NS,carcinoma,undifferentiated carcinoma c.1150C>T p.R384C 12:112482131-112482131 0
11 COSM86055 PTEN endometrium,NS,carcinoma,undifferentiated carcinoma c.18A>C p.K6N 10:87864487-87864487 0
12 COSM3397285 PTEN endometrium,NS,carcinoma,undifferentiated carcinoma c.253G>T p.V85F 10:87931089-87931089 0
13 COSM5282 PTEN endometrium,NS,carcinoma,undifferentiated carcinoma c.242T>G p.F81C 10:87931078-87931078 0
14 COSM5219 PTEN endometrium,NS,carcinoma,undifferentiated carcinoma c.388C>G p.R130G 10:87933147-87933147 0
15 COSM51211 PPP2R1A endometrium,NS,carcinoma,undifferentiated carcinoma c.547C>T p.R183W 19:52212729-52212729 0
16 COSM6954396 PMS1 endometrium,NS,carcinoma,undifferentiated carcinoma c.203T>C p.V68A 2:189795839-189795839 0
17 COSM42912 PIK3R1 endometrium,NS,carcinoma,undifferentiated carcinoma c.1690A>G p.N564D 5:68295269-68295269 0
18 COSM746 PIK3CA endometrium,NS,carcinoma,undifferentiated carcinoma c.263G>A p.R88Q 3:179199088-179199088 0
19 COSM5172190 PIK3CA endometrium,NS,carcinoma,undifferentiated carcinoma c.1826C>A p.P609H 3:179219650-179219650 0
20 COSM754 PIK3CA endometrium,NS,carcinoma,undifferentiated carcinoma c.1035T>A p.N345K 3:179203765-179203765 0
21 COSM6950990 NSD1 endometrium,NS,carcinoma,undifferentiated carcinoma c.1584G>C p.K528N 5:177209983-177209983 0
22 COSM6954399 NSD1 endometrium,NS,carcinoma,undifferentiated carcinoma c.1720G>T p.G574* 5:177210119-177210119 0
23 COSM3283009 NOTCH3 endometrium,NS,carcinoma,undifferentiated carcinoma c.3602G>A p.R1201H 19:15179141-15179141 0
24 COSM6954412 NF1 endometrium,NS,carcinoma,undifferentiated carcinoma c.3604G>A p.A1202T 17:31233109-31233109 0
25 COSM6954409 NCOR1 endometrium,NS,carcinoma,undifferentiated carcinoma c.6553C>T p.P2185S 17:16047077-16047077 0
26 COSM6954394 MTOR endometrium,NS,carcinoma,undifferentiated carcinoma c.80G>A p.S27N 1:11259330-11259330 0
27 COSM516 KRAS endometrium,NS,carcinoma,undifferentiated carcinoma c.34G>T p.G12C 12:25245351-25245351 0
28 COSM88087 KMT2D endometrium,NS,carcinoma,undifferentiated carcinoma c.11902C>T p.R3968C 12:49031993-49031993 0
29 COSM6692617 KDM5C endometrium,NS,carcinoma,undifferentiated carcinoma c.3745C>T p.R1249C 23:53194432-53194432 0
30 COSM6954405 ERBB3 endometrium,NS,carcinoma,undifferentiated carcinoma c.269C>T p.A90V 12:56085029-56085029 0
31 COSM6954413 ERBB2 endometrium,NS,carcinoma,undifferentiated carcinoma c.126C>G p.H42Q 17:39707042-39707042 0
32 COSM6954397 EPHA3 endometrium,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.A401V 3:89341986-89341986 0
33 COSM5672 CTNNB1 endometrium,NS,carcinoma,undifferentiated carcinoma c.94G>A p.D32N 3:41224606-41224606 0
34 COSM5671 CTNNB1 endometrium,NS,carcinoma,undifferentiated carcinoma c.101G>A p.G34E 3:41224613-41224613 0
35 COSM5346998 CTNNB1 endometrium,NS,carcinoma,undifferentiated carcinoma c.599G>A p.R200H 3:41225437-41225437 0
36 COSM6954408 CREBBP endometrium,NS,carcinoma,undifferentiated carcinoma c.959C>T p.T320I 16:3810619-3810619 0
37 COSM6954395 CDC73 endometrium,NS,carcinoma,undifferentiated carcinoma c.215C>A p.P72H 1:193125195-193125195 0
38 COSM931395 CCND1 endometrium,NS,carcinoma,undifferentiated carcinoma c.857C>T p.T286I 11:69651251-69651251 0
39 COSM6913385 AURKA endometrium,NS,carcinoma,undifferentiated carcinoma c.652G>T p.V218F 20:56381486-56381486 0
40 COSM83884 ARID1A endometrium,NS,carcinoma,undifferentiated carcinoma c.3826C>T p.R1276* 1:26773456-26773456 0
41 COSM5347004 ARID1A endometrium,NS,carcinoma,undifferentiated carcinoma c.1820C>A p.S607* 1:26732692-26732692 0
42 COSM51441 ARID1A endometrium,NS,carcinoma,undifferentiated carcinoma c.5161C>T p.R1721* 1:26779059-26779059 0
43 COSM6954398 endometrium,NS,carcinoma,undifferentiated carcinoma c.1202C>T p.A401V 3:89341986-89341986 0
44 COSM6906534 endometrium,NS,carcinoma,undifferentiated carcinoma c.1411C>T p.Q471* 13:48380074-48380074 0
45 COSM1220622 endometrium,NS,carcinoma,undifferentiated carcinoma c.880A>G p.N294D 5:68295269-68295269 0
46 COSM1367318 endometrium,NS,carcinoma,undifferentiated carcinoma c.2359C>T p.R787* 13:48465238-48465238 0
47 COSM99023 endometrium,NS,carcinoma,undifferentiated carcinoma c.128G>A p.R43H 17:7675088-7675088 0
48 COSM6954410 endometrium,NS,carcinoma,undifferentiated carcinoma c.6244C>T p.P2082S 17:16047077-16047077 0
49 COSM99022 endometrium,NS,carcinoma,undifferentiated carcinoma c.524G>A p.R175H 17:7675088-7675088 0
50 COSM6950991 endometrium,NS,carcinoma,undifferentiated carcinoma c.1584G>C p.K528N 5:177209983-177209983 0

Expression for Endometrium Carcinoma in Situ

Search GEO for disease gene expression data for Endometrium Carcinoma in Situ.

Pathways for Endometrium Carcinoma in Situ

Pathways related to Endometrium Carcinoma in Situ according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 PGR TP53

GO Terms for Endometrium Carcinoma in Situ

Molecular functions related to Endometrium Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.96 PGR TP53
2 enzyme binding GO:0019899 8.62 PGR TP53

Sources for Endometrium Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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