EMF
MCID: END021
MIFTS: 51

Endomyocardial Fibrosis (EMF)

Categories: Cardiovascular diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Endomyocardial Fibrosis

MalaCards integrated aliases for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 12 77 54 56 45 15 17 74
Obscure African Cardiomyopathy 12 74
Emf 49 3
African Endomyocardial Fibrosis 12
Becker Muscular Dystrophy 74
Endomyocardial Sclerosis 12
Becker's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12932
ICD9CM 36 425.0
MeSH 45 D004719
NCIt 51 C34585
SNOMED-CT 69 30293000

Summaries for Endomyocardial Fibrosis

CDC : 3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

MalaCards based summary : Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to tropical endomyocardial fibrosis and endocarditis, and has symptoms including weakness An important gene associated with Endomyocardial Fibrosis is CLCN1 (Chloride Voltage-Gated Channel 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Spironolactone and Natriuretic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are integument and craniofacial

Wikipedia : 77 The hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count... more...

Related Diseases for Endomyocardial Fibrosis

Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 262)
# Related Disease Score Top Affiliating Genes
1 tropical endomyocardial fibrosis 33.7 IL10 IL4 TNF
2 endocarditis 30.9 IL10 TNF
3 churg-strauss syndrome 30.6 IL10 TNF
4 filariasis 30.3 IL10 TNF
5 schistosomiasis 30.3 IL10 IL4 TNF
6 hypereosinophilic syndrome 30.3 FIP1L1 IL4 PDGFRA
7 hypereosinophilic syndrome, idiopathic 30.2 FIP1L1 PDGFRA
8 rheumatic heart disease 30.1 IL10 IL4 TNF
9 echinococcosis 30.1 IL10 TNF
10 q fever 29.8 IL10 IL4 TNF
11 chronic eosinophilic leukemia 29.8 FIP1L1 PDGFRA
12 primary hypereosinophilic syndrome 29.8 FIP1L1 PDGFRA
13 loeffler endocarditis 29.8 FIP1L1 PDGFRA
14 parasitic helminthiasis infectious disease 29.8 IL10 IL4 TNF
15 trypanosomiasis 29.7 IL10 IL4 TNF
16 colitis 29.7 IL10 IL4 TNF
17 peritonitis 29.7 IL10 TNF
18 budd-chiari syndrome 29.6 FIP1L1 PDGFRA
19 myeloproliferative neoplasm 29.5 FIP1L1 PDGFRA
20 myotonia congenita, autosomal recessive 11.5
21 fanconi renotubular syndrome 1 11.1
22 heart disease 10.4
23 hemopericardium 10.3
24 pericardial effusion 10.3
25 eosinophilic granulomatosis with polyangiitis 10.3
26 hyperlucent lung 10.3 IL10 IL4
27 nickel allergic contact dermatitis 10.3 IL10 IL4
28 retinitis pigmentosa 22 10.3 IL10 IL4
29 baylisascariasis 10.3 IL10 IL4
30 milk allergy 10.2 IL10 IL4
31 apple allergy 10.2 IL10 IL4
32 beta-lactam allergy 10.2 IL10 IL4
33 gaucher disease, type ii 10.2 IL10 IL4
34 eosinophilic meningitis 10.2 IL10 IL4
35 filarial elephantiasis 10.2 IL10 IL4
36 buruli ulcer 10.2 IL10 IL4
37 bardet-biedl syndrome 15 10.2 IL10 IL4
38 punctate inner choroidopathy 10.2 IL10 TNF
39 genital herpes 10.2 IL10 IL4
40 leukemia 10.2
41 restrictive cardiomyopathy 10.2
42 rere-related disorders 10.2
43 allergic angiitis 10.2
44 paranasal sinus disease 10.2 IL10 IL4
45 transient hypogammaglobulinemia of infancy 10.2 IL10 IL4
46 multifocal choroiditis 10.2 IL10 TNF
47 choroiditis 10.2 IL10 TNF
48 transient hypogammaglobulinemia 10.2 IL10 TNF
49 keratoconjunctivitis 10.2 IL4 TNF
50 cow milk allergy 10.2 IL10 TNF

Comorbidity relations with Endomyocardial Fibrosis via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to Endomyocardial Fibrosis

Symptoms & Phenotypes for Endomyocardial Fibrosis

UMLS symptoms related to Endomyocardial Fibrosis:


weakness

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.72 CLCN1 IL10 IL4 PDGFRA TNF
2 craniofacial MP:0005382 9.71 IL10 IL4 PDGFRA TNF
3 digestive/alimentary MP:0005381 9.67 IL10 IL4 PDGFRA TNF
4 no phenotypic analysis MP:0003012 9.65 CLCN1 IL10 IL4 PDGFRA TNF
5 reproductive system MP:0005389 9.55 CLCN1 IL10 IL4 PDGFRA TNF
6 respiratory system MP:0005388 9.26 IL10 IL4 PDGFRA TNF
7 skeleton MP:0005390 9.02 CLCN1 IL10 IL4 PDGFRA TNF

Drugs & Therapeutics for Endomyocardial Fibrosis

Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
2 Natriuretic Agents Phase 2
3 Mineralocorticoids Phase 2
4 Hormones Phase 2
5 Hormone Antagonists Phase 2
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
7 diuretics Phase 2
8 Mineralocorticoid Receptor Antagonists Phase 2
9 Diuretics, Potassium Sparing Phase 2
10
Levodopa Approved 59-92-7 6047
11
Dopamine Approved 62-31-7, 51-61-6 681
12
Cabergoline Approved 81409-90-7 54746
13 Cardiotonic Agents
14 Sympathomimetics
15 Protective Agents
16 Peripheral Nervous System Agents
17 Neurotransmitter Agents
18 Dopamine agonists
19 Dopamine Agents
20 Autonomic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Spironolactone in Adult Congenital Heart Disease Completed NCT01069510 Phase 2 Spironolactone 25mg
2 Assessment of Myocardial Fibrosis in Aortic STenosis Completed NCT02316587
3 The Genetic Basis of Acquired Heart Disease in Africa Completed NCT02124109
4 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
5 Left Atrial Volume Index in Asymptomatic Aortic Stenosis Completed NCT02395107

Search NIH Clinical Center for Endomyocardial Fibrosis

Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

Anatomical Context for Endomyocardial Fibrosis

MalaCards organs/tissues related to Endomyocardial Fibrosis:

42
Heart, Bone, Bone Marrow, Brain, Liver, Skeletal Muscle, Eye

Publications for Endomyocardial Fibrosis

Articles related to Endomyocardial Fibrosis:

(show top 50) (show all 503)
# Title Authors Year
1
Tricuspid valve relocation with endomyocardial fibrosis removal for Löeffler's endocarditis. ( 30753388 )
2019
2
Endomyocardial fibrosis presenting as apical calcification and infective endocarditis. ( 30753395 )
2019
3
Endomyocardial fibrosis and myocardial infarction leading to diastolic and systolic dysfunction requiring transplantation. ( 30419478 )
2019
4
Complex right atrial mass in endomyocardial fibrosis: a diagnostic dilemma. ( 30612105 )
2019
5
Rapidly progressive endomyocardial fibrosis and heart failure in a 17-year-old female with limited cutaneous systemic sclerosis. ( 30668207 )
2019
6
Endomyocardial fibrosis. Davies disease. Multimodality imaging. ( 30797540 )
2019
7
Surgical resection of restrictive left ventricular endomyocardial fibrosis. ( 30859227 )
2019
8
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2018
9
Ventricular endomyocardial fibrosis in a pregnant female with Behçet's disease. ( 28068787 )
2018
10
Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis. ( 29366603 )
2018
11
Geographical variation in the clinical presentation of endomyocardial fibrosis in India? ( 29455789 )
2018
12
Multimodality imaging in endomyocardial fibrosis associated with Hodgkin lymphoma. ( 29529276 )
2018
13
Non parasitic hypereosinophilia revealing biventricular endomyocardial fibrosis. ( 29875939 )
2018
14
Endomyocardial fibrosis masquerading as metastatic colorectal tumour; myocardial tissue characterization pivotal in guiding urgent surgical management. ( 29912412 )
2018
15
Eosinophilia to endomyocardial fibrosis: Documentation of a case. ( 29922022 )
2018
16
Endomyocardial fibrosis complicating primary hypereosinophilic syndrome. ( 30006894 )
2018
17
Isolated right ventricle endomyocardial fibrosis. An increasingly frequent disease in Spain. ( 30146360 )
2018
18
Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia. ( 30170680 )
2018
19
Endomyocardial Fibrosis: Cardiac Involvement in an HIV-infected Patient. ( 30318187 )
2018
20
Endomyocardial fibrosis and unileaflet mitral valve: a fatal postpartum outcome. ( 30339212 )
2018
21
Löffler Endocarditis and Endomyocardial Fibrosis. ( 28846127 )
2017
22
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ( 28890659 )
2017
23
Diagnosis and Management of Endomyocardial Fibrosis. ( 27886792 )
2017
24
Rare association of endomyocardial fibrosis and Chagas heart disease. ( 28031230 )
2017
25
The key clues to reach the diagnosis of Loeffler endomyocardial fibrosis associated with eosinophilic granulomatosis with polyangiitis. ( 28072629 )
2017
26
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
27
Endomyocardial fibrosis in Sudan: clinical and echocardiographic features. ( 28906536 )
2017
28
Endomyocardial fibrosis in a context of peritonitis. ( 28977410 )
2017
29
Endomyocardial fibrosis. ( 29043203 )
2017
30
Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection. ( 29364349 )
2017
31
Endomyocardial fibrosis and mural thrombus in a 4-year-old girl due to idiopathic hypereosinophilia syndrome described with serial cardiac magnetic resonance imaging. ( 25683059 )
2016
32
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2016
33
Endomyocardial fibrosis: missing tricuspid valve and Fontan-like circulation. ( 26747439 )
2016
34
A Challenging Differential Diagnosis: Distinguishing between Endomyocardial Fibrosis and Apical Hypertrophic Cardiomyopathy. ( 27144839 )
2016
35
A case of biventricular endomyocardial fibrosis complicated by right ventricular outflow tract aneurysms. ( 27245722 )
2016
36
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
37
Endomyocardial Fibrosis Associated With Apical Calcification and High Uptake on Myocardial Gallium-67 Scintigraphy. ( 27477847 )
2016
38
A Rare Case of Mitral Valve Prolapse in Endomyocardial Fibrosis. ( 27549547 )
2016
39
Doughnut appearance of left ventricle in isolated left ventricular endomyocardial fibrosis. ( 27751273 )
2016
40
Bundle branch reentry: A rare mechanism of ventricular tachycardia in endomyocardial fibrosis, without ventricular dilation. ( 27751288 )
2016
41
Endomyocardial fibrosis with right ventricular aneurysm mimicking ARVC - A case report from India. ( 27751343 )
2016
42
Active schistosomiasis, severe hypereosinophilia and rapid progression of chronic endomyocardial fibrosis. ( 27805245 )
2016
43
Coexistence of apical hypertrophic cardiomyopathy and endomyocardial fibrosis with calcification: diagnosis using multimodality imaging. ( 27867529 )
2016
44
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
45
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
46
Severe Left Ventricular Endomyocardial Fibrosis Presenting as Biventricular Failure in a Young Adult: A Case Report. ( 28050425 )
2016
47
Case 3/2015 - 53-year-old female with cardiogenic shock 12 years after surgical correction of endomyocardial fibrosis. ( 26466072 )
2015
48
Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia. ( 26492057 )
2015
49
Cardiac MRI findings of endomyocardial fibrosis (Loeffler's endocarditis) in a patient with rheumatoid arthritis. ( 25870507 )
2015
50
Unusual endomyocardial fibrosis with apical calcification. ( 26066548 )
2015

Variations for Endomyocardial Fibrosis

Expression for Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for Endomyocardial Fibrosis

Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 IL10 IL4 PDGFRA TNF
2
Show member pathways
13.04 IL10 IL4 PDGFRA TNF
3
Show member pathways
12.98 IL10 IL4 PDGFRA TNF
4
Show member pathways
12.5 IL10 IL4 PDGFRA TNF
5
Show member pathways
12.36 IL10 IL4 TNF
6
Show member pathways
12.31 IL10 IL4 TNF
7
Show member pathways
12.29 IL10 PDGFRA TNF
8 12.27 IL10 IL4 TNF
9
Show member pathways
12.24 IL10 IL4 TNF
10
Show member pathways
12.11 IL10 IL4 PDGFRA
11
Show member pathways
11.94 IL10 IL4 TNF
12
Show member pathways
11.77 IL10 IL4 PDGFRA TNF
13 11.64 IL10 IL4 TNF
14 11.6 IL10 IL4 TNF
15
Show member pathways
11.54 IL4 TNF
16 11.53 IL10 TNF
17 11.52 IL10 TNF
18 11.44 IL10 IL4
19 11.43 IL4 TNF
20 11.4 IL10 IL4 TNF
21 11.32 PDGFRA TNF
22 11.3 IL10 TNF
23 11.26 IL10 IL4
24 11.18 IL10 IL4 TNF
25 11.13 IL10 TNF
26 11.09 IL10 TNF
27 11.04 IL4 TNF
28 10.93 IL10 IL4
29 10.88 IL10 IL4 TNF
30 10.82 IL10 IL4 TNF
31 10.64 IL10 IL4 PDGFRA TNF
32 10.26 IL10 IL4 TNF

GO Terms for Endomyocardial Fibrosis

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.75 IL10 IL4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.7 IL10 IL4 TNF
3 B cell differentiation GO:0030183 9.59 IL10 IL4
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 PDGFRA TNF
5 response to glucocorticoid GO:0051384 9.57 IL10 TNF
6 cellular response to amino acid stimulus GO:0071230 9.56 PDGFRA TNF
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 IL10 TNF
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 IL10 IL4
9 negative regulation of mitotic cell cycle GO:0045930 9.51 IL10 TNF
10 negative regulation of interleukin-6 production GO:0032715 9.49 IL10 TNF
11 positive regulation of cytokine secretion GO:0050715 9.48 IL10 TNF
12 regulation of synapse organization GO:0050807 9.46 IL10 TNF
13 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
15 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
18 regulation of isotype switching GO:0045191 9.16 IL10 IL4
19 type 2 immune response GO:0042092 8.96 IL10 IL4
20 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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