EMF
MCID: END021
MIFTS: 54

Endomyocardial Fibrosis (EMF)

Categories: Cardiovascular diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Endomyocardial Fibrosis

MalaCards integrated aliases for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 12 76 53 55 44 15 73
Obscure African Cardiomyopathy 12 73
Emf 48 3
African Endomyocardial Fibrosis 12
Becker Muscular Dystrophy 73
Endomyocardial Sclerosis 12
Becker's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12932
ICD9CM 35 425.0
MeSH 44 D004719
NCIt 50 C34585
SNOMED-CT 68 30293000

Summaries for Endomyocardial Fibrosis

CDC : 3 NIOSH research on protecting workers from proven and possible EMF health risks focuses on:

MalaCards based summary : Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to tropical endomyocardial fibrosis and endocarditis, and has symptoms including weakness An important gene associated with Endomyocardial Fibrosis is CLCN1 (Chloride Voltage-Gated Channel 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Spironolactone and Hormones have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are integument and craniofacial

Wikipedia : 76 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

Related Diseases for Endomyocardial Fibrosis

Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 245)
# Related Disease Score Top Affiliating Genes
1 tropical endomyocardial fibrosis 33.6 IL10 IL4 TNF
2 endocarditis 30.7 IL10 TNF
3 churg-strauss syndrome 30.5 IL10 TNF
4 hypereosinophilic syndrome 30.3 FIP1L1 IL4 PDGFRA
5 filariasis 30.3 IL10 TNF
6 hypereosinophilic syndrome, idiopathic 30.3 FIP1L1 PDGFRA
7 schistosomiasis 30.3 IL10 IL4 TNF
8 rheumatic heart disease 30.1 IL10 IL4 TNF
9 echinococcosis 30.0 IL10 TNF
10 chronic eosinophilic leukemia 29.8 FIP1L1 PDGFRA
11 primary hypereosinophilic syndrome 29.8 FIP1L1 PDGFRA
12 loeffler endocarditis 29.8 FIP1L1 PDGFRA
13 parasitic helminthiasis infectious disease 29.8 IL10 IL4 TNF
14 trypanosomiasis 29.7 IL10 IL4 TNF
15 colitis 29.7 IL10 IL4 TNF
16 peritonitis 29.7 IL10 TNF
17 budd-chiari syndrome 29.6 FIP1L1 PDGFRA
18 myeloproliferative neoplasm 29.6 FIP1L1 PDGFRA
19 myotonia congenita, autosomal recessive 11.4
20 fanconi renotubular syndrome 1 11.1
21 heart disease 10.4
22 hemopericardium 10.3
23 pericardial effusion 10.3
24 restrictive cardiomyopathy 10.2
25 allergic angiitis 10.2
26 childhood leukemia 10.2
27 acquired immunodeficiency syndrome 10.2 IL10 TNF
28 punctate inner choroidopathy 10.2 IL10 TNF
29 microscopic polyangiitis 10.2 IL10 TNF
30 multifocal choroiditis 10.2 IL10 TNF
31 choroiditis 10.2 IL10 TNF
32 transient hypogammaglobulinemia 10.2 IL10 TNF
33 cow milk allergy 10.2 IL10 TNF
34 trichuriasis 10.2 IL10 TNF
35 idiopathic achalasia 10.2 IL10 TNF
36 mucocutaneous leishmaniasis 10.2 IL10 TNF
37 chronic graft versus host disease 10.2 IL10 TNF
38 clonorchiasis 10.2 IL10 TNF
39 trachoma 10.2 IL10 TNF
40 autoimmune disease of eyes, ear, nose and throat 10.2 IL10 TNF
41 intermediate uveitis 10.2 IL10 TNF
42 transverse myelitis 10.2 IL10 TNF
43 malaria 10.2
44 leukemia 10.2
45 post-transplant lymphoproliferative disease 10.2 IL10 TNF
46 multidrug-resistant tuberculosis 10.2 IL10 TNF
47 hemorrhagic fever 10.2 IL10 TNF
48 spotted fever 10.1 IL10 TNF
49 hematopoietic stem cell transplantation 10.1 IL10 TNF
50 aseptic meningitis 10.1 IL10 TNF

Comorbidity relations with Endomyocardial Fibrosis via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to Endomyocardial Fibrosis

Symptoms & Phenotypes for Endomyocardial Fibrosis

UMLS symptoms related to Endomyocardial Fibrosis:


weakness

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.72 CLCN1 IL10 IL4 PDGFRA TNF
2 craniofacial MP:0005382 9.71 IL10 IL4 PDGFRA TNF
3 digestive/alimentary MP:0005381 9.67 IL10 IL4 PDGFRA TNF
4 no phenotypic analysis MP:0003012 9.65 CLCN1 IL10 IL4 PDGFRA TNF
5 reproductive system MP:0005389 9.55 CLCN1 IL10 IL4 PDGFRA TNF
6 respiratory system MP:0005388 9.26 IL10 IL4 PDGFRA TNF
7 skeleton MP:0005390 9.02 CLCN1 IL10 IL4 PDGFRA TNF

Drugs & Therapeutics for Endomyocardial Fibrosis

Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 2 52-01-7, 1952-01-7 5833
2 Hormones Phase 2
3 Natriuretic Agents Phase 2
4 Diuretics, Potassium Sparing Phase 2
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
6 Hormone Antagonists Phase 2
7 Mineralocorticoids Phase 2
8 diuretics Phase 2
9 Mineralocorticoid Receptor Antagonists Phase 2
10
Cabergoline Approved 81409-90-7 54746
11
Dopamine Approved 51-61-6, 62-31-7 681
12
Levodopa Approved 59-92-7 6047
13 Dopamine Agents
14 Peripheral Nervous System Agents
15 Sympathomimetics
16 Dopamine agonists
17 Cardiotonic Agents
18 Protective Agents
19 Autonomic Agents
20 Neurotransmitter Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Spironolactone in Adult Congenital Heart Disease Completed NCT01069510 Phase 2 Spironolactone
2 Assessment of Myocardial Fibrosis in Aortic STenosis Completed NCT02316587
3 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
4 Left Atrial Volume Index in Asymptomatic Aortic Stenosis Completed NCT02395107
5 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109

Search NIH Clinical Center for Endomyocardial Fibrosis

Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

Anatomical Context for Endomyocardial Fibrosis

MalaCards organs/tissues related to Endomyocardial Fibrosis:

41
Heart, Bone, Bone Marrow, Skeletal Muscle, Lung, Brain, Breast

Publications for Endomyocardial Fibrosis

Articles related to Endomyocardial Fibrosis:

(show top 50) (show all 504)
# Title Authors Year
1
Endomyocardial fibrosis and myocardial infarction leading to diastolic and systolic dysfunction requiring transplantation. ( 30419478 )
2019
2
Multimodality imaging in endomyocardial fibrosis associated with Hodgkin lymphoma. ( 29529276 )
2018
3
Non parasitic hypereosinophilia revealing biventricular endomyocardial fibrosis. ( 29875939 )
2018
4
Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis. ( 29366603 )
2018
5
Endomyocardial fibrosis masquerading as metastatic colorectal tumour; myocardial tissue characterization pivotal in guiding urgent surgical management. ( 29912412 )
2018
6
Geographical variation in the clinical presentation of endomyocardial fibrosis in India? ( 29455789 )
2018
7
Eosinophilia to endomyocardial fibrosis: Documentation of a case. ( 29922022 )
2018
8
Endomyocardial fibrosis complicating primary hypereosinophilic syndrome. ( 30006894 )
2018
9
Isolated right ventricle endomyocardial fibrosis. An increasingly frequent disease in Spain. ( 30146360 )
2018
10
Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia. ( 30170680 )
2018
11
Endomyocardial Fibrosis: Cardiac Involvement in an HIV-infected Patient. ( 30318187 )
2018
12
Endomyocardial fibrosis and unileaflet mitral valve: a fatal postpartum outcome. ( 30339212 )
2018
13
LAPffler Endocarditis and Endomyocardial Fibrosis. ( 28846127 )
2017
14
Ventricular endomyocardial fibrosis in a pregnant female with BehAset's disease. ( 28068787 )
2017
15
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ( 28890659 )
2017
16
Endomyocardial fibrosis. ( 29043203 )
2017
17
Endomyocardial fibrosis in a context of peritonitis. ( 28977410 )
2017
18
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2017
19
Diagnosis and Management of Endomyocardial Fibrosis. ( 27886792 )
2017
20
The key clues to reach the diagnosis of Loeffler endomyocardial fibrosis associated with eosinophilic granulomatosis with polyangiitis. ( 28072629 )
2017
21
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
22
Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection. ( 29364349 )
2017
23
Endomyocardial fibrosis in Sudan: clinical and echocardiographic features. ( 28906536 )
2017
24
Rare association of endomyocardial fibrosis and Chagas heart disease. ( 28031230 )
2016
25
A Rare Case of Mitral Valve Prolapse in Endomyocardial Fibrosis. ( 27549547 )
2016
26
Doughnut appearance of left ventricle in isolated left ventricular endomyocardial fibrosis. ( 27751273 )
2016
27
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
28
Coexistence of apical hypertrophic cardiomyopathy and endomyocardial fibrosis with calcification: diagnosis using multimodality imaging. ( 27867529 )
2016
29
Endomyocardial fibrosis with right ventricular aneurysm mimicking ARVC - A case report from India. ( 27751343 )
2016
30
Endomyocardial Fibrosis Associated With Apical Calcification and High Uptake on Myocardial Gallium-67 Scintigraphy. ( 27477847 )
2016
31
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
32
Idiopathic Hypereosinophilic Syndrome Associated with Endomyocardial Fibrosis, Intracardiac Thrombi, Pulmonary and Skin Infiltration: A Case Report. ( 27617583 )
2016
33
Active schistosomiasis, severe hypereosinophilia and rapid progression of chronic endomyocardial fibrosis. ( 27805245 )
2016
34
Endomyocardial fibrosis: missing tricuspid valve and Fontan-like circulation. ( 26747439 )
2016
35
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
36
A Challenging Differential Diagnosis: Distinguishing between Endomyocardial Fibrosis and Apical Hypertrophic Cardiomyopathy. ( 27144839 )
2016
37
A case of biventricular endomyocardial fibrosis complicated by right ventricular outflow tract aneurysms. ( 27245722 )
2016
38
Bundle branch reentry: A rare mechanism of ventricular tachycardia in endomyocardial fibrosis, without ventricular dilation. ( 27751288 )
2016
39
Severe Left Ventricular Endomyocardial Fibrosis Presenting as Biventricular Failure in a Young Adult: A Case Report. ( 28050425 )
2016
40
The safety and efficacy of prednisolone in preventing reaccumulation of ascites among endomyocardial fibrosis patients in Uganda: a randomized clinical trial. ( 26666319 )
2015
41
Endomyocardial fibrosis and mural thrombus in a 4-year-old girl due to idiopathic hypereosinophilia syndrome described with serial cardiac magnetic resonance imaging. ( 25683059 )
2015
42
Cardiac MRI findings of endomyocardial fibrosis (Loeffler's endocarditis) in a patient with rheumatoid arthritis. ( 25870507 )
2015
43
Left ventricular calcification in a patient with endomyocardial fibrosis. ( 26626444 )
2015
44
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2015
45
Case 3/2015 - 53-Year-Old Female with Cardiogenic Shock 12 Years after Surgical Correction of Endomyocardial Fibrosis. ( 26466072 )
2015
46
Restrictive cardiomyopathy as a result of endomyocardial fibrosis from hypereosinophilia. ( 25582942 )
2015
47
Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report. ( 26266372 )
2015
48
Endomyocardial fibrosis in Sub Saharan Africa: The geographical origin, socioeconomic status, and dietary habits of cases reported in Yaounde, Cameroon. ( 26556966 )
2015
49
Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia. ( 26492057 )
2015
50
Unusual endomyocardial fibrosis with apical calcification. ( 26066548 )
2015

Variations for Endomyocardial Fibrosis

Expression for Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for Endomyocardial Fibrosis

Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.09 IL10 IL4 PDGFRA TNF
2
Show member pathways
13.04 IL10 IL4 PDGFRA TNF
3
Show member pathways
12.98 IL10 IL4 PDGFRA TNF
4
Show member pathways
12.5 IL10 IL4 PDGFRA TNF
5
Show member pathways
12.36 IL10 IL4 TNF
6
Show member pathways
12.31 IL10 IL4 TNF
7
Show member pathways
12.29 IL10 PDGFRA TNF
8 12.27 IL10 IL4 TNF
9
Show member pathways
12.11 IL10 IL4 PDGFRA
10
Show member pathways
12.11 IL10 IL4 TNF
11
Show member pathways
11.94 IL10 IL4 TNF
12
Show member pathways
11.77 IL10 IL4 PDGFRA TNF
13 11.64 IL10 IL4 TNF
14 11.6 IL10 IL4 TNF
15
Show member pathways
11.54 IL4 TNF
16 11.53 IL10 TNF
17 11.52 IL10 TNF
18 11.44 IL10 IL4
19 11.43 IL4 TNF
20 11.4 IL10 IL4 TNF
21 11.32 PDGFRA TNF
22 11.3 IL10 TNF
23 11.26 IL10 IL4
24 11.18 IL10 IL4 TNF
25 11.1 IL10 TNF
26 11.09 IL10 TNF
27 11.04 IL4 TNF
28 10.93 IL10 IL4
29 10.88 IL10 IL4 TNF
30 10.82 IL10 IL4 TNF
31 10.64 IL10 IL4 PDGFRA TNF
32 10.26 IL10 IL4 TNF

GO Terms for Endomyocardial Fibrosis

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.75 IL10 IL4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.7 IL10 IL4 TNF
3 B cell differentiation GO:0030183 9.59 IL10 IL4
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.58 PDGFRA TNF
5 response to glucocorticoid GO:0051384 9.57 IL10 TNF
6 cellular response to amino acid stimulus GO:0071230 9.56 PDGFRA TNF
7 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.55 IL10 TNF
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 IL10 IL4
9 negative regulation of mitotic cell cycle GO:0045930 9.51 IL10 TNF
10 negative regulation of interleukin-6 production GO:0032715 9.49 IL10 TNF
11 positive regulation of cytokine secretion GO:0050715 9.48 IL10 TNF
12 regulation of synapse organization GO:0050807 9.46 IL10 TNF
13 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 TNF
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
15 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
17 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
18 regulation of isotype switching GO:0045191 9.16 IL10 IL4
19 type 2 immune response GO:0042092 8.96 IL10 IL4
20 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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