MCID: END021
MIFTS: 51

Endomyocardial Fibrosis

Categories: Rare diseases, Cardiovascular diseases, Muscle diseases

Aliases & Classifications for Endomyocardial Fibrosis

MalaCards integrated aliases for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 12 76 53 55 44 15 73
Obscure African Cardiomyopathy 12 73
African Endomyocardial Fibrosis 12
Becker Muscular Dystrophy 73
Endomyocardial Sclerosis 12
Becker's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12932
ICD9CM 35 425.0
MeSH 44 D004719
NCIt 50 C34585

Summaries for Endomyocardial Fibrosis

MalaCards based summary : Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to tropical endomyocardial fibrosis and churg-strauss syndrome, and has symptoms including weakness An important gene associated with Endomyocardial Fibrosis is CLCN1 (Chloride Voltage-Gated Channel 1), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Spironolactone and diuretics have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are integument and craniofacial

Wikipedia : 76 The hypereosinophilic syndrome (HES) is a disease characterized by a persistently elevated eosinophil... more...

Related Diseases for Endomyocardial Fibrosis

Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 tropical endomyocardial fibrosis 33.3 IL10 IL4 TNF
2 churg-strauss syndrome 30.7 IL10 TNF
3 endocarditis 30.6 IL10 TNF
4 filariasis 30.4 IL10 TNF
5 hypereosinophilic syndrome, idiopathic 30.0 FIP1L1 PDGFRA
6 schistosomiasis 30.0 IL10 IL4 TNF
7 rheumatic heart disease 29.9 IL10 IL4 TNF
8 peritonitis 29.7 IL10 TNF
9 loeffler endocarditis 29.5 FIP1L1 PDGFRA
10 hypereosinophilic syndrome 29.5 FIP1L1 IL4 PDGFRA
11 chronic eosinophilic leukemia 29.5 FIP1L1 PDGFRA
12 trypanosomiasis 29.5 IL10 IL4 TNF
13 colitis 29.5 IL10 IL4 TNF
14 budd-chiari syndrome 29.2 FIP1L1 PDGFRA
15 myotonia congenita, autosomal recessive 11.3
16 scleritis 10.5 IL4 TNF
17 microscopic colitis 10.5 IL4 TNF
18 lichen disease 10.5 IL4 TNF
19 punctate inner choroidopathy 10.5 IL10 TNF
20 microscopic polyangiitis 10.5 IL10 TNF
21 rasmussen encephalitis 10.5 IL4 TNF
22 multifocal choroiditis 10.5 IL10 TNF
23 transient hypogammaglobulinemia 10.5 IL10 TNF
24 choroiditis 10.4 IL10 TNF
25 idiopathic achalasia 10.4 IL10 TNF
26 trichuriasis 10.4 IL10 TNF
27 mucocutaneous leishmaniasis 10.4 IL10 TNF
28 clonorchiasis 10.4 IL10 TNF
29 trachoma 10.4 IL10 TNF
30 listeriosis 10.4 IL10 TNF
31 transverse myelitis 10.4 IL10 TNF
32 intermediate uveitis 10.4 IL10 TNF
33 multidrug-resistant tuberculosis 10.4 IL10 TNF
34 post-transplant lymphoproliferative disease 10.4 IL10 TNF
35 hemorrhagic fever 10.4 IL10 TNF
36 spotted fever 10.4 IL10 TNF
37 hematopoietic stem cell transplantation 10.4 IL10 TNF
38 panuveitis 10.4 IL10 TNF
39 aseptic meningitis 10.4 IL10 TNF
40 scrub typhus 10.4 IL10 TNF
41 hyperlucent lung 10.4 IL10 IL4
42 cytomegalovirus infection 10.4 IL10 TNF
43 plasmodium vivax malaria 10.4 IL10 TNF
44 immunoglobulin a deficiency 1 10.4 IL10 IL4
45 tonsillitis 10.4 IL4 TNF
46 q fever 10.4 IL10 TNF
47 lacrimal apparatus disease 10.4 IL10 TNF
48 retinitis pigmentosa 22 10.4 IL10 IL4
49 baylisascariasis 10.4 IL10 IL4
50 severe hemophilia a 10.4 IL10 TNF

Comorbidity relations with Endomyocardial Fibrosis via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease Ischemic Heart Disease

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to Endomyocardial Fibrosis

Symptoms & Phenotypes for Endomyocardial Fibrosis

UMLS symptoms related to Endomyocardial Fibrosis:


weakness

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.72 CLCN1 IL10 IL4 PDGFRA TNF
2 craniofacial MP:0005382 9.71 IL10 IL4 PDGFRA TNF
3 digestive/alimentary MP:0005381 9.67 IL10 IL4 PDGFRA TNF
4 no phenotypic analysis MP:0003012 9.65 CLCN1 IL10 IL4 PDGFRA TNF
5 reproductive system MP:0005389 9.55 CLCN1 IL10 IL4 PDGFRA TNF
6 respiratory system MP:0005388 9.26 TNF IL10 IL4 PDGFRA
7 skeleton MP:0005390 9.02 CLCN1 IL10 IL4 PDGFRA TNF

Drugs & Therapeutics for Endomyocardial Fibrosis

Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Spironolactone Approved Phase 2 1952-01-7, 52-01-7 5833
2 diuretics Phase 2
3 Diuretics, Potassium Sparing Phase 2
4 Hormone Antagonists Phase 2
5 Hormones Phase 2
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
7 Mineralocorticoid Receptor Antagonists Phase 2
8 Mineralocorticoids Phase 2
9 Natriuretic Agents Phase 2
10
Cabergoline Approved 81409-90-7 54746
11
Dopamine Approved 51-61-6, 62-31-7 681
12
Levodopa Approved 59-92-7 6047
13 Autonomic Agents
14 Dopamine Agents
15 Dopamine agonists
16 Neurotransmitter Agents
17 Peripheral Nervous System Agents
18 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Spironolactone in Adult Congenital Heart Disease Completed NCT01069510 Phase 2 Spironolactone
2 Assessment of Myocardial Fibrosis in Aortic STenosis Completed NCT02316587
3 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
4 Left Atrial Volume Index in Asymptomatic Aortic Stenosis Completed NCT02395107
5 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109

Search NIH Clinical Center for Endomyocardial Fibrosis

Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

Anatomical Context for Endomyocardial Fibrosis

MalaCards organs/tissues related to Endomyocardial Fibrosis:

41
Heart, Bone, Bone Marrow, Skin, Testes, Lung, Skeletal Muscle

Publications for Endomyocardial Fibrosis

Articles related to Endomyocardial Fibrosis:

(show top 50) (show all 481)
# Title Authors Year
1
Multimodality imaging in endomyocardial fibrosis associated with Hodgkin lymphoma. ( 29529276 )
2018
2
Non parasitic hypereosinophilia revealing biventricular endomyocardial fibrosis. ( 29875939 )
2018
3
Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis. ( 29366603 )
2018
4
Endomyocardial fibrosis masquerading as metastatic colorectal tumour; myocardial tissue characterization pivotal in guiding urgent surgical management. ( 29912412 )
2018
5
Geographical variation in the clinical presentation of endomyocardial fibrosis in India? ( 29455789 )
2018
6
Eosinophilia to endomyocardial fibrosis: Documentation of a case. ( 29922022 )
2018
7
LAPffler Endocarditis and Endomyocardial Fibrosis. ( 28846127 )
2017
8
Ventricular endomyocardial fibrosis in a pregnant female with BehAset's disease. ( 28068787 )
2017
9
Loeffler Endocarditis: A Unique Presentation of Right-Sided Heart Failure Due to Eosinophil-Induced Endomyocardial Fibrosis. ( 28890659 )
2017
10
Endomyocardial fibrosis. ( 29043203 )
2017
11
Endomyocardial fibrosis in a context of peritonitis. ( 28977410 )
2017
12
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. ( 28818409 )
2017
13
Diagnosis and Management of Endomyocardial Fibrosis. ( 27886792 )
2017
14
The key clues to reach the diagnosis of Loeffler endomyocardial fibrosis associated with eosinophilic granulomatosis with polyangiitis. ( 28072629 )
2017
15
Progressive mitral regurgitation in a patient with tropical endomyocardial fibrosis. ( 28582525 )
2017
16
Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection. ( 29364349 )
2017
17
Endomyocardial fibrosis in Sudan: clinical and echocardiographic features. ( 28906536 )
2017
18
Rare association of endomyocardial fibrosis and Chagas heart disease. ( 28031230 )
2016
19
A Rare Case of Mitral Valve Prolapse in Endomyocardial Fibrosis. ( 27549547 )
2016
20
Doughnut appearance of left ventricle in isolated left ventricular endomyocardial fibrosis. ( 27751273 )
2016
21
Letter by Kothari Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881499 )
2016
22
Coexistence of apical hypertrophic cardiomyopathy and endomyocardial fibrosis with calcification: diagnosis using multimodality imaging. ( 27867529 )
2016
23
Endomyocardial fibrosis with right ventricular aneurysm mimicking ARVC - A case report from India. ( 27751343 )
2016
24
Endomyocardial Fibrosis Associated With Apical Calcification and High Uptake on Myocardial Gallium-67 Scintigraphy. ( 27477847 )
2016
25
Response by Grimaldi et al to Letter Regarding Article, "Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives". ( 27881500 )
2016
26
Idiopathic Hypereosinophilic Syndrome Associated with Endomyocardial Fibrosis, Intracardiac Thrombi, Pulmonary and Skin Infiltration: A Case Report. ( 27617583 )
2016
27
Active schistosomiasis, severe hypereosinophilia and rapid progression of chronic endomyocardial fibrosis. ( 27805245 )
2016
28
Endomyocardial fibrosis: missing tricuspid valve and Fontan-like circulation. ( 26747439 )
2016
29
Tropical Endomyocardial Fibrosis: Natural History, Challenges, and Perspectives. ( 27297343 )
2016
30
A Challenging Differential Diagnosis: Distinguishing between Endomyocardial Fibrosis and Apical Hypertrophic Cardiomyopathy. ( 27144839 )
2016
31
A case of biventricular endomyocardial fibrosis complicated by right ventricular outflow tract aneurysms. ( 27245722 )
2016
32
Bundle branch reentry: A rare mechanism of ventricular tachycardia in endomyocardial fibrosis, without ventricular dilation. ( 27751288 )
2016
33
Severe Left Ventricular Endomyocardial Fibrosis Presenting as Biventricular Failure in a Young Adult: A Case Report. ( 28050425 )
2016
34
The safety and efficacy of prednisolone in preventing reaccumulation of ascites among endomyocardial fibrosis patients in Uganda: a randomized clinical trial. ( 26666319 )
2015
35
Endomyocardial fibrosis and mural thrombus in a 4-year-old girl due to idiopathic hypereosinophilia syndrome described with serial cardiac magnetic resonance imaging. ( 25683059 )
2015
36
Cardiac MRI findings of endomyocardial fibrosis (Loeffler's endocarditis) in a patient with rheumatoid arthritis. ( 25870507 )
2015
37
Left ventricular calcification in a patient with endomyocardial fibrosis. ( 26626444 )
2015
38
Non-tropical endomyocardial fibrosis: A rare cause of bi-apical filling. ( 26456913 )
2015
39
Case 3/2015 - 53-Year-Old Female with Cardiogenic Shock 12 Years after Surgical Correction of Endomyocardial Fibrosis. ( 26466072 )
2015
40
Restrictive cardiomyopathy as a result of endomyocardial fibrosis from hypereosinophilia. ( 25582942 )
2015
41
Reversible Severe Eosinophilic Endomyocardial Fibrosis During Pregnancy: A Case Report. ( 26266372 )
2015
42
Endomyocardial fibrosis in Sub Saharan Africa: The geographical origin, socioeconomic status, and dietary habits of cases reported in Yaounde, Cameroon. ( 26556966 )
2015
43
Successful Heart Transplantation for Unreversible Endomyocardial Fibrosis Related to FIP1L1-PDGFRA Chronic Eosinophilic Leukemia. ( 26492057 )
2015
44
Unusual endomyocardial fibrosis with apical calcification. ( 26066548 )
2015
45
Isolated Severe Right Ventricle Endomyocardial Fibrosis in a Child: Vanishing Tropical Disease Revisited. ( 26578670 )
2015
46
How to recognize endomyocardial fibrosis? ( 25050531 )
2014
47
Genetic susceptibility to endomyocardial fibrosis. ( 25780800 )
2014
48
Endomyocardial fibrosis associated with Schistosoma haematobium infection. ( 25709139 )
2014
49
Republished: Recent advances in the epidemiology, diagnosis and treatment of endomyocardial fibrosis in Africa. ( 24336311 )
2014
50
Predominant RV endomyocardial fibrosis masking rheumatic mitral stenosis. ( 25508015 )
2014

Variations for Endomyocardial Fibrosis

Expression for Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for Endomyocardial Fibrosis

Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 IL10 IL4 PDGFRA TNF
2
Show member pathways
13.02 IL10 IL4 PDGFRA TNF
3
Show member pathways
12.96 IL10 IL4 PDGFRA TNF
4
Show member pathways
12.45 IL10 IL4 PDGFRA TNF
5
Show member pathways
12.27 IL10 PDGFRA TNF
6 12.24 IL10 IL4 TNF
7
Show member pathways
12.09 IL10 IL4 TNF
8
Show member pathways
12.06 IL10 IL4 TNF
9
Show member pathways
12.05 IL10 IL4 PDGFRA TNF
10
Show member pathways
11.88 IL10 IL4 TNF
11 11.61 IL10 IL4 TNF
12 11.55 IL10 IL4 TNF
13
Show member pathways
11.51 IL4 TNF
14 11.51 IL10 TNF
15 11.49 IL10 TNF
16 11.4 IL10 IL4
17 11.4 IL4 TNF
18 11.34 IL10 IL4 TNF
19 11.29 PDGFRA TNF
20 11.27 IL10 TNF
21 11.23 IL10 IL4
22 11.08 IL10 TNF
23 11.07 IL10 TNF
24 11.02 IL4 TNF
25 10.87 IL10 IL4
26 10.82 IL10 IL4 TNF
27 10.28 IL10 IL4 TNF

GO Terms for Endomyocardial Fibrosis

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.74 IL10 IL4 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.71 IL10 IL4 TNF
3 B cell differentiation GO:0030183 9.58 IL10 IL4
4 response to glucocorticoid GO:0051384 9.56 IL10 TNF
5 cellular response to amino acid stimulus GO:0071230 9.55 PDGFRA TNF
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 IL10 TNF
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.51 IL10 IL4
8 negative regulation of mitotic cell cycle GO:0045930 9.49 IL10 TNF
9 positive regulation of cytokine secretion GO:0050715 9.48 IL10 TNF
10 negative regulation of interleukin-6 production GO:0032715 9.46 IL10 TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 TNF
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 IL10 TNF
13 endothelial cell apoptotic process GO:0072577 9.37 IL10 TNF
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IL10 IL4
15 negative regulation of cytokine secretion involved in immune response GO:0002740 9.26 IL10 TNF
16 type 2 immune response GO:0042092 9.16 IL10 IL4
17 regulation of isotype switching GO:0045191 8.96 IL10 IL4
18 receptor biosynthetic process GO:0032800 8.62 IL10 TNF

Molecular functions related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL10 IL4 TNF

Sources for Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....