EMF
MCID: END021
MIFTS: 49

Endomyocardial Fibrosis (EMF)

Categories: Cardiovascular diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Endomyocardial Fibrosis

MalaCards integrated aliases for Endomyocardial Fibrosis:

Name: Endomyocardial Fibrosis 12 74 52 54 43 15 17 71
Obscure African Cardiomyopathy 12 71
African Endomyocardial Fibrosis 12
Becker Muscular Dystrophy 71
Endomyocardial Sclerosis 12
Becker's Disease 12
Emf 47

Classifications:



External Ids:

Disease Ontology 12 DOID:12932
ICD9CM 34 425.0
MeSH 43 D004719
NCIt 49 C34585
SNOMED-CT 67 30293000
UMLS 71 C0553980 C0917713 C1959600

Summaries for Endomyocardial Fibrosis

MalaCards based summary : Endomyocardial Fibrosis, also known as obscure african cardiomyopathy, is related to tropical endomyocardial fibrosis and restrictive cardiomyopathy, and has symptoms including weakness An important gene associated with Endomyocardial Fibrosis is CLCN1 (Chloride Voltage-Gated Channel 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Carvedilol and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and bone, and related phenotypes are homeostasis/metabolism and integument

Wikipedia : 74 Hypereosinophilic syndrome is a disease characterized by a persistently elevated eosinophil count (?... more...

Related Diseases for Endomyocardial Fibrosis

Diseases related to Endomyocardial Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 tropical endomyocardial fibrosis 34.4 TNF IL4 IL10
2 restrictive cardiomyopathy 31.4 PDGFRA FIP1L1 CLCN1
3 endocarditis 31.3 TNF IL10 EPX
4 rheumatic heart disease 31.0 TNF IL4 IL10
5 filariasis 30.7 TNF IL5 IL10
6 myocarditis 30.7 TNF IL4 IL10
7 chagas disease 30.6 TNF IL4 IL10
8 q fever 30.4 TNF IL4 IL10
9 hypereosinophilic syndrome, idiopathic 30.2 PDGFRB PDGFRA IL5 FIP1L1
10 plasmodium falciparum malaria 30.2 TNF IL4 IL10
11 pulmonary tuberculosis 30.2 TNF IL4 IL10
12 trypanosomiasis 30.2 TNF IL4 IL10
13 peritonitis 30.2 TNF IL4 IL10
14 primary hypereosinophilic syndrome 30.1 PDGFRB PDGFRA FIP1L1
15 erythema multiforme 30.0 TNF IL5 IL4
16 schistosomiasis 30.0 TNF RNASE3 IL5 IL4 IL10
17 granulomatosis with polyangiitis 29.8 TNF IL5 FIP1L1
18 status asthmaticus 29.8 RNASE3 IL5 IL10
19 trichinosis 29.6 RNASE2 IL5 IL4 IL10
20 loeffler syndrome 29.6 PRG2 IL5 FIP1L1
21 echinococcosis 29.6 TNF RNASE3 IL5 IL10
22 churg-strauss syndrome 29.5 TNF RNASE3 PRG2 IL5 IL10
23 parasitic helminthiasis infectious disease 29.5 TNF RNASE3 IL5 IL4 IL10
24 chronic eosinophilic leukemia 28.8 PDGFRB PDGFRA IL5 FIP1L1 CHIC2
25 hypereosinophilic syndrome 28.7 RNASE3 PRG2 PDGFRB PDGFRA IL5 IL4
26 loeffler endocarditis 28.5 RNASE3 RNASE2 PRG2 PDGFRA IL5 FIP1L1
27 allergic hypersensitivity disease 28.2 TNF RNASE3 PRG2 IL5 IL4 IL10
28 myotonia congenita, autosomal recessive 11.6
29 fibrosis of extraocular muscles, congenital, 1 11.2
30 atrial standstill 1 10.5
31 mitral valve insufficiency 10.5
32 punctate inner choroidopathy 10.5 TNF IL10
33 hemopericardium 10.5
34 pericardial effusion 10.5
35 childhood leukemia 10.5
36 multifocal choroiditis 10.5 TNF IL10
37 choroiditis 10.5 TNF IL10
38 spotted fever rickettsiosis 10.5 TNF IL10
39 palladium allergic contact dermatitis 10.5 TNF IL10
40 pericarditis 10.4
41 pdgfra-associated chronic eosinophilic leukemia 10.4 PDGFRA FIP1L1
42 autoimmune hepatitis type 1 10.4 IL4 IL10
43 metal allergy 10.4 IL4 IL10
44 pulmonary hypertension 10.4
45 tricuspid valve insufficiency 10.4
46 congestive heart failure 10.4
47 combined thymoma 10.4 TNF IL10
48 constrictive pericarditis 10.4
49 post-transplant lymphoproliferative disease 10.4 TNF IL10
50 transient hypogammaglobulinemia 10.4 TNF IL10

Comorbidity relations with Endomyocardial Fibrosis via Phenotypic Disease Network (PDN):


Acute Cystitis Familial Atrial Fibrillation
Heart Disease

Graphical network of the top 20 diseases related to Endomyocardial Fibrosis:



Diseases related to Endomyocardial Fibrosis

Symptoms & Phenotypes for Endomyocardial Fibrosis

UMLS symptoms related to Endomyocardial Fibrosis:


weakness

MGI Mouse Phenotypes related to Endomyocardial Fibrosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.85 CLCN1 EPX IL10 IL4 IL5 PDGFRA
2 integument MP:0010771 9.5 CHIC2 CLCN1 IL10 IL4 PDGFRA PDGFRB
3 no phenotypic analysis MP:0003012 9.1 CLCN1 IL10 IL4 PDGFRA SLC16A2 TNF

Drugs & Therapeutics for Endomyocardial Fibrosis

Drugs for Endomyocardial Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Ramipril Approved Phase 4 87333-19-5 5362129
3
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
4
Sodium citrate Approved, Investigational Phase 4 68-04-2
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
8 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
9
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
10
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
11
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
12
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
13 Adrenergic Antagonists Phase 4
14 Adrenergic beta-Antagonists Phase 4
15 Adrenergic alpha-Antagonists Phase 4
16 Calcium, Dietary Phase 4
17 Antioxidants Phase 4
18 calcium channel blockers Phase 4
19 Hormones Phase 4
20 Protective Agents Phase 4
21 Vasodilator Agents Phase 4
22 Phosphodiesterase 5 Inhibitors Phase 4
23 Phosphodiesterase Inhibitors Phase 4
24 Anti-Inflammatory Agents Phase 4
25 Sildenafil Citrate Phase 4 171599-83-0
26 Citrate Phase 4
27 Autonomic Agents Phase 4
28 Methylprednisolone Acetate Phase 4
29 glucocorticoids Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 Hormone Antagonists Phase 4
32 Gastrointestinal Agents Phase 4
33 Antiemetics Phase 4
34 Neuroprotective Agents Phase 4
35
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
36
Enalaprilat Approved Phase 3 76420-72-9 6917719
37 HIV Protease Inhibitors Phase 3
38 Antihypertensive Agents Phase 3
39
protease inhibitors Phase 3
40 Angiotensin-Converting Enzyme Inhibitors Phase 3
41
Metformin Approved Phase 2 657-24-9 4091 14219
42
Spironolactone Approved Phase 2 52-01-7, 1952-01-7 5833
43
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
44
Epicatechin Investigational Phase 1, Phase 2 35323-91-2, 490-46-0 72276
45 Tea Phase 1, Phase 2
46 Hypoglycemic Agents Phase 2
47 Mineralocorticoids Phase 2
48 Mineralocorticoid Receptor Antagonists Phase 2
49 Natriuretic Agents Phase 2
50 diuretics Phase 2

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 Effects of Cardioprotective Therapy, Carvedilol vs Ramipril, in Patients Affected by Duchenne and Becker Muscular Dystrophy. Clinical Significance and Prognostic Value of Cardiac Magnetic Resonance Study. Unknown status NCT00819845 Phase 4 carvedilol;ramipril
2 Functional Muscle Ischemia and PDE5A Inhibition in Becker Muscular Dystrophy Completed NCT01070511 Phase 4 Tadalafil;Placebo
3 A Comparative Study of Strategies for Management of Duchenne Myopathy in Assiut University Children Hospital Not yet recruiting NCT03633565 Phase 4 Sildenafil (Phosphodiesterase inhibitors);Prednisolone (Steroids)
4 Effects of Sodium Nitrate on Blood Flow in Becker Muscular Dystrophy Unknown status NCT02147639 Phase 2, Phase 3
5 Myocardial Fibrosis Progression in Duchenne and Becker Muscular Dystrophy - Angiotensin-Converting-Enzyme (ACE) Inhibitor Therapy Completed NCT02432885 Phase 3 Enalapril
6 An Open-Label Study for Previously Treated Ataluren (PTC124) Patients With Nonsense Mutation Dystrophinopathy Completed NCT01557400 Phase 3 Ataluren
7 A Phase 3 Extension Study of Ataluren (PTC124) in Patients With Nonsense Mutation Dystrophinopathy Completed NCT02090959 Phase 3 Ataluren
8 A Phase 3 Efficacy and Safety Study of Ataluren (PTC124) in Patients With Nonsense Mutation Dystrophinopathy Completed NCT01826487 Phase 3 Ataluren;Placebo
9 A Phase 3, Randomized, Double-blind, Placebo-controlled Efficacy and Safety Study of Ataluren in Patients With Nonsense Mutation Duchenne Muscular Dystrophy and Open-Label Extension Recruiting NCT03179631 Phase 3 Ataluren;PLACEBO
10 An Open-Label, Safety Study for Previously Treated Ataluren (PTC124) Patients With Nonsense Mutation Dystrophinopathy Enrolling by invitation NCT01247207 Phase 3 Ataluren
11 A Phase 2b Extension Study of Ataluren (PTC124) in Subjects With Nonsense-Mutation-Mediated Duchenne and Becker Muscular Dystrophy Terminated NCT00847379 Phase 2, Phase 3 Ataluren (PTC124)
12 An Open-label, Un-controlled, Single-centre Trial Investigating the Efficacy and Safety of CRD007 in Children With Duchenne Muscular Dystrophy (DMD) or Becker Muscular Dystrophy (BMD) or Children Being Symptomatic Carriers for DMD or BMD Completed NCT01540604 Phase 2 CRD007
13 An Open-label Pilot Study of Purified Tea-derived Epicatechin to Improve Mitochondrial Function, Strength and Skeletal Muscle Exercise Response in Becker Muscular Dystrophy. Completed NCT01856868 Phase 1, Phase 2 (-)-epicatechin
14 Study Evaluating MYO-029 in Adult Muscular Dystrophy Completed NCT00104078 Phase 1, Phase 2 MYO-029
15 UCD0115B: An Open-label Extension Study of Purified Epicatechin to Improve Mitochondrial Function, Strength and Skeletal Muscle Exercise Response in Becker Muscular Dystrophy Completed NCT03236662 Phase 2 (-)-Epicatechin
16 A Phase 2b Efficacy and Safety Study of PTC124 in Subjects With Nonsense-Mutation-Mediated Duchenne Muscular Dystrophy and Becker Muscular Dystrophy Completed NCT00592553 Phase 2 PTC124 High Dose;PTC124 Low Dose;Placebo
17 Pilot Study to Assess the Efficacy of L-Citrulline and Metformin in Adults With Becker's Muscular Dystrophy Completed NCT02018731 Phase 2 Metformin and Metformin & L-Citrulline;L-Citrulline and Metformin & L-Citrulline
18 Does Modulation of the nNOS System in Patients With Muscular Dystrophy and Defect nNOS Signalling Affect Cardiac, Muscular or Cognitive Function? Completed NCT01350154 Phase 2 Sildenafil;Placebo
19 Heart Failure in Congenital Heart Disease: the Role of Myocardial Fibrosis. Treatment Sub-Study: Spironolactone vs. Placebo Completed NCT01069510 Phase 2 Spironolactone 25mg
20 A Randomised, Double Blind, Placebo Controlled Study to Evaluate the Micro-macroscopic Effects on Muscles, the Safety and Tolerability, and the Efficacy of Givinostat in Patients With Becker Muscular Dystrophy (BMD) Recruiting NCT03238235 Phase 2 givinostat;placebo
21 Open Label Safety and Efficacy of Once Weekly Steroid in Patients With LGMD and Becker Muscular Dystrophy Enrolling by invitation NCT04054375 Phase 2 Prednisone
22 A Phase 2a Study of Ataluren (PTC124) in Nonambulatory Patients With Nonsense-Mutation-Mediated Duchenne/Becker Muscular Dystrophy Terminated NCT01009294 Phase 2 Ataluren (PTC124)
23 Phase 2 Clinical Trial of Sildenafil for Cardiac Dysfunction in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy Terminated NCT01168908 Phase 2 Sildenafil
24 Sodium Nitrate for Muscular Dystrophy Unknown status NCT02434627 Phase 1 Sodium Nitrate
25 Sodium Nitrate to Improve Blood Flow Completed NCT02847975 Phase 1
26 Phase I Clinical Intramuscular Gene Transfer of rAAV1.CMV.huFollistatin344 Trial to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body Myositis. Completed NCT01519349 Phase 1
27 Gentamicin Treatment of Patients With Muscular Dystrophy Due to Nonsense Mutations in Dystrophin Completed NCT00005574 Phase 1 Gentamicin
28 Efficacy and the Safety of Granulocyte Colony-stimulating Factor Treatment in Children and Adolescents With Muscular Dystrophy: An Open Study Recruiting NCT02814110 Phase 1 Granulocyte colony-stimulating factor (Filgrastim)
29 Prospective Cohort Study of Patients With Mutations in the Dystrophin Gene (X Linked Dilated Cardiomyopathy and Becker Muscular Dystrophy) Unknown status NCT02020954
30 Skeletal Muscle Blood Flow in Becker Muscular Dystrophy Unknown status NCT02653833 Early Phase 1 Tadalafil 20 MG
31 Muscle Oxygenation Modification During Effort in 4 Groups of Neuromuscular Diseases Compared to Healthy Controls, and Mitochondrial Function and Phenotype Assessment Unknown status NCT02789059
32 Muscle MRI Study of Patients With Becker Muscular Dystrophy and Limb-girdle Muscular Dystrophy Type 2I Completed NCT02165358
33 Effect of Eicosapentaenoic Fatty Acid (EPA) and Docosahexaenoic Fatty Acids (DHA) Supplementation on the Inflammation State and Metabolic Disorders in Patients With Duchenne Muscular Dystrophy or Becker Muscular Dystrophy Completed NCT01826422
34 Where Does Hope Fit In? The Relationship Between Hope, Uncertainty, and Coping Efficacy in Mothers of Children With Duchenne/Becker Muscular Dystrophy Completed NCT02194725
35 Evaluation of Limb-Girdle Muscular Dystrophy Completed NCT00893334
36 Acceptance and Commitment Therapy for Muscle Disease Completed NCT02810028
37 The Genetic Basis of Acquired Heart Disease in Africa Completed NCT02124109
38 Assessment of Myocardial Fibrosis - Impact on Postoperative Outcome i Patients With Severe Aortic STenosis Undergoing Aortic Valve Replacement Completed NCT02316587
39 Left Atrial Volume Index - Impact on LV Remodeling, LV Function and Functional Capacity in Asymptomatic Aortic Valve Stenosis Completed NCT02395107
40 EVALUATION OF TWO SECONDARY CARE STRATEGIES AFTER STROKE OR TRANSIENT ISCHEMIC ATTACK (TIA): ACHEIVED TARGET LDL-C TO 100 mg/dL (+/- 10,mg/dL) OR LESS THAN 70 mg/dL. Completed NCT01252875
41 The Pan African Pulmonary Hypertension Cohort Study Completed NCT02265887
42 A Registered Cohort Study on Duchenne Muscular Dystrophy Recruiting NCT04012671
43 The Duchenne Registry: An International, Patient-Report Registry for Individuals With Duchenne and Becker Muscular Dystrophy (Member of TREAT-NMD Neuromuscular Network) Recruiting NCT02069756
44 Biomarker for Duchenne Disease AN INTERNATIONAL, MULTICENTER, EPIDEMIOLOGICAL PROTOCOL Recruiting NCT02994030
45 Study of the Correlation Between Muscle Oxygenation and Motor Function in Children With Neuromuscular Disease. Recruiting NCT03471676
46 Pilot Study of Cardiac Magnetic Resonance in Patients With Muscular Dystrophy Recruiting NCT02921321
47 Quantification of Muscle Specific microRNAs in the Serum of Patients With Duchenne Muscular Dystrophy (DMD) and Becker (BMD) : Evaluation of the Inters-est of These Biomarkers in Patients Care Recruiting NCT02109692
48 Molecular Analysis of Nucleic Acids Derived From Patients With Neuromuscular Disease and Their Family Members Recruiting NCT00390104
49 PITT0112: Becker Muscular Dystrophy - A Natural History Study to Predict Efficacy of Exon Skipping Active, not recruiting NCT01539772
50 Cardiac Involvement in Patients With Duchenne/Becker Muscular Dystrophy Active, not recruiting NCT02470962

Search NIH Clinical Center for Endomyocardial Fibrosis

Cochrane evidence based reviews: endomyocardial fibrosis

Genetic Tests for Endomyocardial Fibrosis

Anatomical Context for Endomyocardial Fibrosis

MalaCards organs/tissues related to Endomyocardial Fibrosis:

40
Heart, Bone Marrow, Bone, Skeletal Muscle, Brain, Liver, Testes

Publications for Endomyocardial Fibrosis

Articles related to Endomyocardial Fibrosis:

(show top 50) (show all 940)
# Title Authors PMID Year
1
Endomyocardial Fibrosis: an Update After 70 Years. 61
31758352 2019
2
Endomyocardial fibrosis presented by ventricular tachycardia: case report. 61
31745734 2019
3
Endomyocardial Fibrosis: Cardiac Involvement in an HIV-infected Patient. 61
30318187 2019
4
Endomyocardial fibrosis of the right ventricle: A case report of successful surgery. 61
31778572 2019
5
Exercise Rehabilitation Improves Cardiac Volumes and Functional Capacity in Patients With Endomyocardial Fibrosis: A RANDOMIZED CONTROLLED TRIAL. 61
31397769 2019
6
Endomyocardial fibrosis and apical thrombus in patient with hypereosinophilia. 61
31364702 2019
7
Tricuspid valve relocation with endomyocardial fibrosis removal for Löeffler's endocarditis. 61
30753388 2019
8
New-onset heart failure: free-breathing motion-corrected late gadolinium enhancement rescues the endomyocardial fibrosis diagnosis. 61
31562499 2019
9
Isolated right ventricle endomyocardial fibrosis. An increasingly frequent disease in Spain. 61
30146360 2019
10
Echocardiography in Indigenous Populations and Resource Poor Settings. 61
31272827 2019
11
Endomyocardial fibrosis: past, present, and future. 61
31414216 2019
12
Apical hypertrophic cardiomyopathy with apical endomyocardial fibrosis and calcification: Two case reports. 61
31277123 2019
13
Rapidly progressive endomyocardial fibrosis and heart failure in a 17-year-old female with limited cutaneous systemic sclerosis. 61
30668207 2019
14
Endomyocardial fibrosis and calcification in an elderly patient. 61
31312583 2019
15
Surgical resection of restrictive left ventricular endomyocardial fibrosis. 61
30859227 2019
16
Eosinophilic Endomyocardial Fibrosis (Löffler Endocarditis) in a 4-Year-Old Patient. 61
31142138 2019
17
Mitral and tricuspid valve repair in hypereosinophilic syndrome. 61
31253659 2019
18
Clinical, epidemiological and echocardiographic features and prognostic factors in cats with restrictive cardiomyopathy: A retrospective study of 92 cases (2001-2015). 61
30924221 2019
19
Loeffler's endocarditis with isolated left ventricular involvement on cardiac MRI. 61
31005861 2019
20
Fourteen-year-old boy with decreased appetite and pedal swelling. 61
30242138 2019
21
Endomyocardial fibrosis presenting as apical calcification and infective endocarditis. 61
30753395 2019
22
[Cardiac manifestations of tropical diseases]. 61
30656388 2019
23
Endomyocardial fibrosis. Davies disease. Multimodality imaging. 61
30797540 2019
24
Endomyocardial fibrosis and myocardial infarction leading to diastolic and systolic dysfunction requiring transplantation. 61
30419478 2019
25
Complex right atrial mass in endomyocardial fibrosis: a diagnostic dilemma. 61
30612105 2019
26
[Hypoxic hepatitis in a patient with endomyocardial fibrosis]. 61
31487249 2019
27
Endomyocardial fibrosis and unileaflet mitral valve: a fatal postpartum outcome. 61
30339212 2018
28
Endomyocardial fibrosis masquerading as metastatic colorectal tumour; myocardial tissue characterization pivotal in guiding urgent surgical management. 61
29912412 2018
29
Endomyocardial fibrosis complicating primary hypereosinophilic syndrome. 61
30006894 2018
30
Ventricular endomyocardial fibrosis in a pregnant female with Behçet's disease. 61
28068787 2018
31
Endomyocardial Fibrosis With End-Stage Heart Failure as a Consequence of a Myeloproliferative Neoplasm With Hypereosinophilia. 61
30170680 2018
32
Multimodality imaging in endomyocardial fibrosis associated with Hodgkin lymphoma. 61
29529276 2018
33
Right Heart-Pulmonary Circulation Unit in Cardiomyopathies and Storage Diseases. 61
29966629 2018
34
Case Report: Probable Case of Spontaneous Encephalopathy Due to Loiasis and Dramatic Reduction of Loa loa Microfilariaemia with Prolonged Repeated Courses of Albendazole. 61
29741149 2018
35
FIP1L1-PDGFRA fusion-negative hypereosinophilic syndrome with uncommon cardiac involvement responding to imatinib treatment: A case report. 61
29977537 2018
36
Heart Failure in Sub-Saharan Africa. 61
29892471 2018
37
Eosinophilia to endomyocardial fibrosis: Documentation of a case. 61
29922022 2018
38
Prevalence and characteristics of primary left-sided valve disease in a cohort of 15,000 patients undergoing echocardiography studies in a tertiary hospital in Uganda. 61
29728065 2018
39
[Tropical endomyocardial fibrosis: Perspectives]. 61
29602442 2018
40
Endomyocardial Fibrosis: A Rare Case of Diastolic Heart Failure in a European Caucasian Elderly Woman. 61
28818409 2018
41
Loeffler endocarditis as a rare cause of heart failure with preserved ejection fraction: A case report and review of literature. 61
29538200 2018
42
Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis. 61
29366603 2018
43
Geographical variation in the clinical presentation of endomyocardial fibrosis in India? 61
29455789 2018
44
Non parasitic hypereosinophilia revealing biventricular endomyocardial fibrosis. 61
29875939 2018
45
An Unusual Case of Tricuspid Stenosis. 61
30756028 2018
46
Acquired heart disease in low-income and middle-income countries. 61
28838969 2018
47
Characterization of Cardiopulmonary Exercise Testing Variables in Patients with Endomyocardial Fibrosis after Endocardial Resection. 61
29364349 2017
48
Endomyocardial fibrosis in a context of peritonitis. 61
28977410 2017
49
Eosinophilic Myocarditis. 61
29173361 2017
50
The key clues to reach the diagnosis of Loeffler endomyocardial fibrosis associated with eosinophilic granulomatosis with polyangiitis. 61
28072629 2017

Variations for Endomyocardial Fibrosis

Expression for Endomyocardial Fibrosis

Search GEO for disease gene expression data for Endomyocardial Fibrosis.

Pathways for Endomyocardial Fibrosis

Pathways related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 TNF RNASE3 RNASE2 PRG2 PDGFRB PDGFRA
2
Show member pathways
13.25 TNF PDGFRB PDGFRA IL5 IL4 IL10
3
Show member pathways
13.2 TNF PDGFRB PDGFRA IL5 IL4 IL10
4
Show member pathways
13.11 TNF PDGFRB PDGFRA IL5 IL4 IL10
5
Show member pathways
12.45 TNF IL5 IL4 IL10
6
Show member pathways
12.44 TNF IL5 IL4 IL10
7
Show member pathways
12.43 TNF PDGFRB PDGFRA IL10
8
Show member pathways
12.09 PDGFRB PDGFRA IL5 IL4 IL10
9
Show member pathways
11.97 TNF RNASE3 PRG2 PDGFRA IL5 IL4
10
Show member pathways
11.94 TNF PDGFRB PDGFRA IL5 IL4 IL10
11 11.84 TNF IL4 IL10
12 11.8 TNF IL5 IL4 IL10
13 11.75 TNF IL5 IL4
14
Show member pathways
11.61 TNF IL5 IL4
15 11.57 TNF IL4 IL10
16 11.57 TNF IL5 IL4 IL10
17 11.51 TNF IL5 IL4
18 11.5 IL5 IL4 IL10
19 11.36 TNF IL4 IL10
20 11.32 IL5 IL4 IL10
21 11.14 TNF IL5 IL4
22 11 IL5 IL4 IL10
23 10.73 PDGFRB PDGFRA
24 10.72 TNF IL5 IL4 IL10
25 10.6 TNF PRG2 PDGFRB PDGFRA IL5 IL4

GO Terms for Endomyocardial Fibrosis

Cellular components related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 TNF RNASE3 RNASE2 PRG2 IL5 IL4

Biological processes related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.87 TNF IL5 IL4 IL10
2 immune response GO:0006955 9.85 TNF PRG2 IL5 IL4 IL10
3 MAPK cascade GO:0000165 9.8 TNF PDGFRB PDGFRA IL5
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.77 TNF IL5 IL10
5 defense response to Gram-positive bacterium GO:0050830 9.77 TNF RNASE3 RNASE2
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 TNF PDGFRB PDGFRA
7 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL10
8 cardiac myofibril assembly GO:0055003 9.61 PDGFRB PDGFRA
9 positive regulation of phospholipase C activity GO:0010863 9.58 PDGFRB PDGFRA
10 positive regulation of podosome assembly GO:0071803 9.58 TNF IL5
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.55 IL4 IL10
12 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.54 IL4 IL10
13 endothelial cell apoptotic process GO:0072577 9.52 TNF IL10
14 retina vasculature development in camera-type eye GO:0061298 9.51 PDGFRB PDGFRA
15 induction of bacterial agglutination GO:0043152 9.48 RNASE3 RNASE2
16 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 TNF IL10
17 type 2 immune response GO:0042092 9.4 IL4 IL10
18 regulation of isotype switching GO:0045191 9.37 IL4 IL10
19 metanephric glomerular capillary formation GO:0072277 9.32 PDGFRB PDGFRA
20 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.26 PDGFRB PDGFRA
21 receptor biosynthetic process GO:0032800 9.16 TNF IL10
22 positive regulation of JAK-STAT cascade GO:0046427 9.13 TNF IL5 IL10
23 defense response to bacterium GO:0042742 9.02 TNF RNASE3 PRG2 IL10 EPX

Molecular functions related to Endomyocardial Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet-derived growth factor receptor binding GO:0005161 9.26 PDGFRB PDGFRA
2 platelet-derived growth factor binding GO:0048407 9.16 PDGFRB PDGFRA
3 vascular endothelial growth factor binding GO:0038085 8.96 PDGFRB PDGFRA
4 cytokine activity GO:0005125 8.92 TNF IL5 IL4 IL10

Sources for Endomyocardial Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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