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MCID: END047
MIFTS: 53

Endophthalmitis

Categories: Eye diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Endophthalmitis

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MalaCards integrated aliases for Endophthalmitis:

Name: Endophthalmitis 12 58 54 44 15 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:4692
MeSH 44 D009877
NCIt 50 C34586
SNOMED-CT 67 1847009
ICD10 32 H45.1
MESH via Orphanet 45 D009877
ICD10 via Orphanet 33 H44.0 H44.1
UMLS via Orphanet 72 C0014236
Orphanet 58 ORPHA199323
UMLS 71 C0014236
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Summaries for Endophthalmitis

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Disease Ontology : 12 A globe disease that is characterized by inflammation of the inside of the eye.

MalaCards based summary : Endophthalmitis is related to acute endophthalmitis and purulent endophthalmitis, and has symptoms including redness or discharge of eye An important gene associated with Endophthalmitis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are TGF-Beta Pathway and PI3K-Akt signaling pathway. The drugs Lidocaine and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Endophthalmitis is inflammation of the interior cavity of the eye, usually caused by infection. It is a... more...

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Related Diseases for Endophthalmitis

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Diseases in the Endophthalmitis family:

Chronic Endophthalmitis Acute Endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1025)
# Related Disease Score Top Affiliating Genes
1 acute endophthalmitis 32.6 VEGFA PRF1
2 purulent endophthalmitis 32.4 VEGFA PRF1
3 panophthalmitis 31.1 SAG CRP
4 sympathetic ophthalmia 31.0 TNF SELE ICAM1
5 hypopyon 31.0 VEGFA TNF IL6 IL1B CRP
6 retinal detachment 30.9 VEGFA TNF IL6 HMGB1 CXCL8
7 panuveitis 30.8 TNF SAG IL6 CRP
8 scleritis 30.8 TNF SELE CRP
9 diabetic macular edema 30.7 VEGFA IL6 ICAM1
10 iridocyclitis 30.6 VEGFA TNF IL6 IL1B CRP
11 vasculitis 30.5 TNF SELE IL6 ICAM1 CRP
12 iritis 30.5 VEGFA TNF IL6 CRP
13 choroiditis 30.5 VEGFA TNF SAG
14 haemophilus influenzae 30.4 TNF TLR2 CXCL8
15 infective endocarditis 30.4 TNF TLR2 IL6 CRP
16 mycobacterium chelonae 30.3 TLR2 CXCL8
17 kuhnt-junius degeneration 30.3 VEGFB VEGFA PLG PGF CRYAA
18 keratopathy 30.3 TNF ICAM1 CXCL8
19 uveitis 30.3 TNF SAG IL6 IL1B ICAM1 CXCL8
20 severe cutaneous adverse reaction 30.3 TNF PRF1 CRP
21 posterior uveitis 30.3 TNF SAG IL6
22 vitreous detachment 30.3 VEGFB VEGFA PLG PGF
23 chorioretinitis 30.2 VEGFA TNF SAG IL6 IL1B CRP
24 cellulitis 30.2 TNF IL6 CRP ALB
25 retinal ischemia 30.1 VEGFA TNF CRYAA
26 mycobacterium abscessus 30.1 TNF TLR2 CXCL8
27 cataract 30.1 VEGFA TNF IL6 ICAM1 CXCL8 CRYAA
28 conjunctivitis 30.1 TNF PLG IL6 ICAM1 CXCL8
29 keratitis, hereditary 30.1 VEGFA TNF TLR2 IL6 IL1B CXCL8
30 perforated corneal ulcer 30.1 PRF1 PLG CRP
31 rubeosis iridis 30.0 VEGFA PLG
32 branch retinal artery occlusion 30.0 VEGFA PLG CRYAA CRP
33 erythema multiforme 30.0 TNF IL6 ICAM1 CXCL8
34 retinal vein occlusion 30.0 VEGFA TNF IL6 IL1B CXCL8
35 mucormycosis 29.9 CRP CARD9 ALB
36 septic arthritis 29.9 TLR2 CXCL8 CRP
37 hydrocele 29.9 VEGFA SELE ICAM1
38 central retinal artery occlusion 29.9 VEGFA PLG CRYAA CRP
39 retinal disease 29.9 SAG HMGB1 CRYAA ALB
40 disseminated intravascular coagulation 29.9 TNF PLG IL6 HMGB1 CRP
41 microvascular complications of diabetes 5 29.9 VEGFA PLG PGF ICAM1 CRYAA ALB
42 invasive aspergillosis 29.9 TLR2 PLG CXCL8
43 cardiogenic shock 29.8 TNF IL6
44 anterior scleritis 29.8 TNF CRP
45 toxoplasmosis 29.8 TNF TLR2 IL6 IL1B
46 aspergillosis 29.8 TNF TLR2 IL6 IL1B CXCL8
47 macular holes 29.8 VEGFA PLG IL6 CXCL8 CRYAA
48 sarcoidosis 1 29.8 TNF IL1B ICAM1 CRP
49 fasciitis 29.8 TNF IL6 CXCL8
50 gas gangrene 29.7 PRF1 IL6 CRP

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to Endophthalmitis
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Symptoms & Phenotypes for Endophthalmitis

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UMLS symptoms related to Endophthalmitis:


redness or discharge of eye

MGI Mouse Phenotypes related to Endophthalmitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ALB CARD9 CRP ICAM1 IL1B IL6
2 cardiovascular system MP:0005385 10.25 ALB CRP ICAM1 IL1B IL6 PGF
3 growth/size/body region MP:0005378 10.22 ICAM1 IL1B IL6 LGALS1 PGF PLG
4 immune system MP:0005387 10.17 ALB CARD9 CRP ICAM1 IL1B IL6
5 integument MP:0010771 10 ICAM1 IL1B IL6 LGALS1 PGF PLG
6 liver/biliary system MP:0005370 9.76 ALB IL6 PLG PRF1 SELE TLR2
7 neoplasm MP:0002006 9.65 ALB ICAM1 IL1B IL6 PGF PLG
8 respiratory system MP:0005388 9.23 IL6 LGALS1 PGF PLG SELE TLR2
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Drugs & Therapeutics for Endophthalmitis

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Drugs for Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
2
Cefazolin Approved Phase 4 25953-19-9 656510 33255
3
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
4
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
5
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
6
Polyestradiol phosphate Approved Phase 4 28014-46-2
7
Povidone-iodine Approved Phase 4 25655-41-8
8
Iodine Approved, Investigational Phase 4 7553-56-2 807
9
Povidone Approved Phase 4 9003-39-8 131751496
10
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
13
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
14
Cadexomer iodine Experimental Phase 4 94820-09-4
15 Anti-Infective Agents Phase 4
16 Anti-Bacterial Agents Phase 4
17 Antibiotics, Antitubercular Phase 4
18 Anesthetics Phase 4
19 Sodium Channel Blockers Phase 4
20 Cephalosporins Phase 4
21 Anesthetics, Local Phase 4
22 Diuretics, Potassium Sparing Phase 4
23 Anti-Arrhythmia Agents Phase 4
24 Estradiol 3-benzoate Phase 4
25 Contraceptive Agents Phase 4
26 Contraceptives, Oral Phase 4
27 Contraceptives, Oral, Combined Phase 4
28 Estradiol 17 beta-cypionate Phase 4
29 Pharmaceutical Solutions Phase 4
30 Ophthalmic Solutions Phase 4
31 Clindamycin palmitate Phase 4
32 Clindamycin phosphate Phase 4
33 Gentamicins Phase 4
34 Anti-Inflammatory Agents Phase 4
35 Hormone Antagonists Phase 4
36 Hormones Phase 4
37 glucocorticoids Phase 4
38 Immunosuppressive Agents Phase 4
39 Gastrointestinal Agents Phase 4
40 Immunologic Factors Phase 4
41 triamcinolone acetonide Phase 4
42 Triamcinolone hexacetonide Phase 4
43 Triamcinolone diacetate Phase 4
44 BB 1101 Phase 4
45 Antineoplastic Agents, Hormonal Phase 4
46 Antiemetics Phase 4
47 Anti-Infective Agents, Local Phase 4
48
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
49
Moxifloxacin Approved, Investigational Phase 3 151096-09-2, 354812-41-2 152946
50
Vancomycin Approved Phase 3 1404-90-6 441141 14969

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Cefazolin-Lidocaine Solution for Reducing Pain Associated With Subconjunctival Antibiotic Prophylaxis in Vitreo-Retinal Surgery Unknown status NCT02324166 Phase 4 Cefazolin;Lidocaine
2 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
3 Postoperative Safety Outcomes in Patients Undergoing Routine Phacoemulsification Cataract Surgery With Intraoperative Intracameral Injection of Preservative-Free Moxifloxacin Versus Levofloxacin Completed NCT04403334 Phase 4 Levofloxacin Ophthalmic;Moxifloxacin Ophthalmic
4 Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis Completed NCT00398658 Phase 4 gentamycin and clindamycin
5 A Two Different Chemoprophylaxis Approaches After Phacoemulsification Surgery in One Thousand Patients in Iraq :a Clinical Trial Completed NCT03634852 Phase 4 Moxifloxacin hydrochloride 0.5% eye drops;Dexamethasone 0.1% eye drops;Intracameral Moxifloxacin 0.1%;Subconjunctival Triamcinolone acetonide 4 mg /0.4 ml
6 Prospective, Randomized, Double-blind Comparison of 5 % Against 1.25 % Povidone-iodine Solution as Preoperative Antisepsis for Strabismus Surgery in Young Children Completed NCT00461656 Phase 4 Preoperative conjunctival irrigation with 5% or 1.25% PI
7 Evaluation and Comparison of Macular and Choroidal Thickness After Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis Recruiting NCT03363295 Phase 4 Moxifloxacin Injection
8 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis. Completed NCT01768078 Phase 3
9 Endophthalmitis Vitrectomy Study (EVS) Completed NCT00000130 Phase 3 Intravitreal Antibiotics
10 Safety and Efficacy of Intracameral Zimoxin (0.1% Moxifloxacin Solution) for Prevention of Endophthalmitis After Cataract Surgery Not yet recruiting NCT03244072 Phase 2, Phase 3 Moxifloxacin;Placebo
11 Intracameral Antibiotic Safety Study Not yet recruiting NCT02590523 Phase 3 Vancomycin;Moxifloxacin;Placebo
12 Effect of Hypochlorous Acid Disinfection on Ocular Flora Prior to Cataract Surgery Not yet recruiting NCT04568213 Phase 3 Hypochlorous Acid Gel 0.02%
13 Use of Intracameral Moxifloxacin for the Prevention of Acute Endophthalmitis Following Cataract Surgery: a Controlled and Randomized Clinical Trial Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
14 Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis Completed NCT02595359 Phase 2 Moxifloxacin
15 The Pharmacokinetics of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5% Recruiting NCT04214821 Phase 1, Phase 2 Levofloxacin Ophthalmic Solution;Moxifloxacin Ophthalmic Solution
16 The Clinical Safety of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5% Recruiting NCT04212429 Phase 1, Phase 2 Levofloxacin Ophthalmic Product;Moxifloxacin Ophthalmic Solution
17 Intracameral Levofloxacin (0.5%) Versus Intracameral Cefuroxime (1mg/0.1ml) Effect on Corneal Endothelial Cell Count and Morphology in Uneventful Phacoemulsification Recruiting NCT04212078 Phase 1, Phase 2 Levofloxacin Ophthalmic;Cefuroxime
18 Effect of Topical Besifloxacin on Ocular Surface Bacterial Microbiota Prior to Cataract Surgery Completed NCT04542759 Phase 1 Besifloxacin Ophthalmic;Hydroxypropyl Methylcellulose Ophthalmic Ophthalmic Solution
19 Concentrating on Antisepsis: 5% vs. 10% Povidone-Iodine Prior to Intravitreal Injection Unknown status NCT03420820
20 Incidence of Endophthalmitis After Intravitreous Anti-vascular Endothelial Growth Factor Injections Comparison Between Patients Receiving Versus Not Receiving Topical Antibiotics Following the Injections Unknown status NCT02810587 Topical antibiotics following injection
21 Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis Unknown status NCT02850653
22 Comparison Between Nylon and Polyglactin Corneal Suture in Pediatric Cataract Surgery: a Randomized Controlled Clinical Trial Unknown status NCT03812640
23 The Effect of Intracameral Cefuroxime on Post-op Fibrin in Pediatric Cataract Surgery Completed NCT00730938 cefuroxime;Saline placebo
24 Combined Endophthalmitis and Orbital Cellulitis in Patients With Novel Coronavirus Disease (COVID-19) Completed NCT04456556
25 Conjunctival Floral Resistance in a Single Practice Site Comparing Povidone- Iodine Prep With or Without Post-Intravitreal Injection Second Generation Fluoroquinolones. Completed NCT02223338 Ciprofloxacin;Standard Aseptic Technique
26 Endogenous Endophthalmitis Rates, Clinical Course, and Outcomes Completed NCT01323868
27 Endophthalmitis After Intravitreal Injection of Antiangiogenic Agents or Corticosteroids, a Cohort Study of the French Population of Patients Who Received Injections Over 9 Years Completed NCT03635268
28 Assessment of Conjunctival Flora and Optimal Ocular Sterilization Technique Prior to Cataract Surgery Using Intranasal Mupirocin Ointment Completed NCT00406913 mupirocin ointment
29 Antibiotic Prophylaxis for Cataract Surgery Version 7e January 22 2003 Completed NCT00136344 Cefuroxime;Levofloxacin
30 Severe Intraocular Infection Completed NCT02818062
31 Evaluation of Conjunctival Flora Alteration in Patients Undergoing Cataract Surgery Completed NCT03958292
32 Early Empirical Versus Pre-emptive Systemic Anti-fungal Therapy in Acute-on-Chronic Liver Failure Patients With Suspected Invasive Fungal Infections: a Randomized Controlled Trial Recruiting NCT04157465
33 Multiplex Strip PCR for Valid, Fast and Comprehensive Multi-pathogen Detection to Support the Diagnosis of Eye Infection Diseases (Endophthalmitis, Keratitis, Corneal Ulcers) From Corneal Scraping Samples Recruiting NCT04075669
34 Intraocular Concentrations Study (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis Recruiting NCT03968341
35 Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis Recruiting NCT04192994 Intravitreal Antibiotic Injection
36 Endophthalmitis Post Intravitreal Injections Comparison EPIIC Trial: Pars Plana Vitrectomy Versus Tap and Inject Recruiting NCT04035369
37 Early Vitrectomy and Intravitreal Antibiotics for Post-operative Exogenous Endophthalmitis: A Feasibility Multicentre Randomised Controlled Trial (EVIAN Study) Not yet recruiting NCT04522661
38 Prospective Surveillance of Patients With Endophthalmitis for Multi-antibiotic Resistance (PROSPER) Study Terminated NCT01496794
39 Device Exposure Registry: A Post-Approval Observational Registry of ReSure Sealant to Track the Incidence of Endophthalmitis After Sealing Corneal Incisions in Patients Undergoing Clear Corneal Cataract Surgery Withdrawn NCT02309736
40 The Effect of Preoperative Topical Gatifloxacin on Anterior Chamber Sample Cultures After Cataract Surgery. Withdrawn NCT00335231 gatifloxacin ophthalmic (ZYMAR)

Search NIH Clinical Center for Endophthalmitis

Cochrane evidence based reviews: endophthalmitis

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Genetic Tests for Endophthalmitis

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Anatomical Context for Endophthalmitis

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MalaCards organs/tissues related to Endophthalmitis:

40
Eye, Endothelial, Retina, Liver, Myeloid, Skin, Colon
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Publications for Endophthalmitis

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Articles related to Endophthalmitis:

(show top 50) (show all 8290)
# Title Authors PMID Year
1
Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis. 61 54
9423880 1998
2
Virulence of enterococci. 61 54
7834601 1994
3
Criteria for intravitreal antibiotics during surgical removal of intraocular foreign bodies. 54 61
1286707 1992
4
ENDOPHTHALMITIS AFTER TRANSCONJUNCTIVAL PARS PLANA VITRECTOMY: A 6-year Experience Without Prophylactic Intraoperative Subconjunctival Antibiotics. 61
32826794 2021
5
Nutritionally variant streptococci causing endophthalmitis associated with intravitreal anti-vascular endothelial growth factor injection. 61
33553806 2021
6
Severe ocular and adnexal complications in dengue hemorrhagic fever: A report of 29 eyes. 61
33595487 2021
7
Safety profile of minimally invasive glaucoma surgery. 61
33315726 2021
8
Ethylenediaminetetraacetic Acid Chelation in Herpes Zoster Ophthalmicus Is Associated With a High Rate of Corneal Melt and Perforation. 61
33264147 2021
9
Endophthalmitis after strabismus surgery: incidence and outcome in relation to age, operated eye muscle, surgical technique, scleral perforation and immune state. 61
32533628 2021
10
Factors affecting final functional outcomes in open-globe injuries and use of ocular trauma score as a predictive tool in Nepalese population. 61
33541290 2021
11
Endophthalmitis prophylaxis failures in patients injected with intracameral antibiotic during cataract surgery. 61
33571472 2021
12
Endogenous endophthalmitis associated with lens dislocation and vitreous gas bubble in a diabetic patient. 61
33608172 2021
13
Surveillance of post-cataract endophthalmitis at a tertiary referral center: a 10-year critical evaluation. 61
33593443 2021
14
Commentary: Intravitreal moxifloxacin for acute postoperative endophthalmitis: Is it as safe and efficacious as the age-old recommended intravitreal vancomycin and ceftazidime? 61
33463585 2021
15
[Treatment of postoperative endophthalmitis : Operate or only inject?] 61
33566160 2021
16
Bilateral endophthalmitis following bilateral same-day anti-VEGF injections. 61
32533656 2021
17
Difference in Host Immune response to Methicillin-Resistant and Methicillin Sensitive Staphylococcus aureus (MRSA and MSSA) Endophthalmitis. 61
33560179 2021
18
Vancomycin-loaded N,N-dodecyl,methyl-polyethylenimine nanoparticles coated with hyaluronic acid to treat bacterial endophthalmitis: Development, characterization, and ocular biocompatibility. 61
33310092 2021
19
CLINICAL UTILITY OF BETA-D-GLUCAN TESTING FOR ENDOGENOUS FUNGAL CHORIORETINITIS OR ENDOPHTHALMITIS. 61
32516224 2021
20
Streptococcus salivarius endogenous endophthalmitis. 61
33541999 2021
21
Intravitreal moxifloxacin injections in acute post-cataract surgery endophthalmitis: Efficacy and safety. 61
33463584 2021
22
Cluster of Post-Operative Endophthalmitis Caused by Acanthamoeba T10 Genotype - A First Report. 61
33201060 2021
23
Candidemia in Children: A 16-year Longitudinal Epidemiologic Study. 61
33591077 2021
24
Immediate onset of sterile endophthalmitis with hypopyon after intravitreal Brolucizumab in a case of polypoidal choroidal vasculopathy. 61
33463623 2021
25
Efficacy and Pharmacokinetics of Fosmanogepix (APX001) in the Treatment of Candida Endophthalmitis and Hematogenous Meningoencephalitis in Nonneutropenic Rabbits. 61
33361304 2021
26
Twenty years of endophthalmitis: Incidence, aetiology and clinical outcome. 61
32567150 2021
27
Nasolacrimal obstruction concomitant to cataract: diagnosis and management in the preoperative period of cataract surgery. 61
33567033 2021
28
Incidence of Fungal Infection in Positive Donor Rim Cultures after Corneal Transplantation. 61
33560899 2021
29
Incidence of Retinal Detachment after Macular Surgery. 61
33607691 2021
30
VISUAL OUTCOME OF EARLY VITRECTOMY AND INTRAVITREAL ANTIBIOTICS IN ACUTE POSTSURGICAL AND POSTINTRAVITREAL INJECTION ENDOPHTHALMITIS: European Vitreo-Retinal Society Endophthalmitis Study Report Two. 61
32467482 2021
31
Safety of nurse-led intravitreal injection of dexamethasone (Ozurdex) implant service. Audit of first 1000 cases. 61
32728227 2021
32
The simply modified intrascleral fixation using round flange (SMURF) technique for intrascleral intraocular lens fixation. 61
33594097 2021
33
Anterior chamber tap cytology in acute postoperative endophthalmitis: a case-control study. 61
33574032 2021
34
Comparative efficacy and safety of different regimens of ranibizumab for neovascular age-related macular degeneration: a network meta-analysis of randomised controlled trials. 61
33550238 2021
35
Ocular spectrum of kite injury: A six-year trend at a tertiary eye care center. 61
33463575 2021
36
Conjunctival bacterial flora and their antibiotic sensitivity among patients scheduled for cataract surgery in a tertiary hospital in south-east Nigeria. 61
32936360 2021
37
Pyogenic Liver Abscess and Endogenous Endophthalmitis Due to K64-ST1764 Hypervirulent Klebsiella pneumoniae: A Case Report. 61
33469321 2021
38
Bacterial contamination of intravitreal needles by the ocular surface microbiome. 61
32497656 2021
39
Endogenous Endophthalmitis Caused by Group B Streptococcus in a Healthy, Term Neonate. 61
33492072 2021
40
Corneo-limbo-conjunctival transposition to treat deep and perforating corneal ulcers in dogs: A review of 418 eyes and corneal clarity scoring in 111 eyes. 61
33034144 2021
41
Endogenous fungal endophthalmitis: risk factors, clinical course, and visual outcome in 13 patients. 61
33469490 2021
42
Endophthalmitis after cataract surgery: an update on recent advances. 61
33196543 2021
43
Commonly used intracameral antibiotics for endophthalmitis prophylaxis: A literature review. 61
32343980 2021
44
Effectiveness of immediate vitrectomy and intravitreal antibiotics for post-injection endophthalmitis. 61
33502628 2021
45
Ten-year trends in the incidence, clinical profile and outcomes of acute-onset endophthalmitis following combined pars plana vitrectomy and sutureless, glueless and flapless scleral fixation of intraocular lenses. 61
33511515 2021
46
The laser combined with intravitreal injection of ranibizumab for treatment of macular edema secondary to branch retinal vein occlusion: A protocol for systematic review and meta-analysis. 61
33530168 2021
47
Efficacy of intracameral antibiotics following manual small incision cataract surgery in reducing the rates of endophthalmitis: A meta-analysis. 61
33426771 2021
48
Visual function deficits in eyes with resolved endophthalmitis. 61
33504844 2021
49
Endophthalmitis following Intravitreal Anti-Vascular Endothelial Growth Factor Therapy: Changes in Incidence and Outcomes over a 9-Year Period. 61
33522314 2021
50
Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review. 61
32808064 2021
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Variations for Endophthalmitis

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Expression for Endophthalmitis

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Search GEO for disease gene expression data for Endophthalmitis.
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Pathways for Endophthalmitis

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Pathways related to Endophthalmitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
TGF-Beta Pathway 63
Show member pathways
 13.56 VEGFB VEGFA TNF PGF IL6 IL1B
2
PI3K-Akt signaling pathway 36
Show member pathways
 13.02 VEGFB VEGFA TNF TLR2 PGF IL6
3
Human cytomegalovirus infection 36
Show member pathways
 12.98 VEGFA TNF TLR2 IL6 IL1B ICAM1
4
Allograft rejection 36 1
Show member pathways
 12.84 VEGFA TNF PRF1 IL6 IL1B ICAM1
5
Measles 36
Show member pathways
 12.82 TNF TLR2 PLG IL6 IL1B ICAM1
6
Herpes simplex virus 1 infection 36
12.81 TNF TLR2 IL6 IL1B CARD9
7
MAPK signaling pathway 36 1
12.78 VEGFB VEGFA TNF PGF IL1B
8
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.77 TNF TLR2 IL6 IL1B CXCL8 CARD9
9
Salmonella infection (KEGG) 36
Show member pathways
 12.76 TNF TLR2 IL6 IL1B CXCL8
10
NF-KappaB Family Pathway 63
Show member pathways
 12.75 VEGFB TNF TLR2 PGF IL6 IL1B
11
NF-kappaB Signaling 4
12.6 TNF TLR2 LGALS1 IL1B CARD9
12
IL-17 Family Signaling Pathways 64
Show member pathways
 12.39 TNF TLR2 IL6 IL1B CXCL8
13
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.29 TNF TLR2 IL6 CXCL8
14
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.29 VEGFB TNF PGF IL6 IL1B CXCL8
15
NOD-like receptor signaling pathway 36
12.27 TNF IL6 IL1B CXCL8 CARD9
16
Tuberculosis 36
12.26 TNF TLR2 IL6 IL1B CARD9
17
C-type lectin receptor signaling pathway 36
Show member pathways
 12.24 TNF IL6 IL1B CARD9
18
Folate Metabolism 1
Show member pathways
 12.24 TNF PLG IL6 IL1B ICAM1 CRP
19
Colorectal Cancer Metastasis 63
12.21 VEGFA TNF TLR2 IL6
20
Bacterial infections in CF airways 23
Show member pathways
 12.2 TNF TLR2 IL6 IL1B CXCL8
21
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.18 VEGFA TNF IL6 IL1B CXCL8
22
Yersinia infection 36
12.12 TNF IL6 IL1B CXCL8
23
Fluid shear stress and atherosclerosis 36
12.09 VEGFA TNF SELE IL1B ICAM1
24
Spinal Cord Injury 1
12.01 TNF IL6 IL1B ICAM1 CXCL8
25
NF-kappa B signaling pathway 36
11.98 TNF IL1B ICAM1 CXCL8
26
TNF signaling pathway 36
11.97 TNF SELE IL6 IL1B ICAM1
27
Interleukin-4 and 13 signaling 65
11.94 VEGFA TNF IL6 IL1B ICAM1 CXCL8
28
Amoebiasis 36
11.92 TNF TLR2 IL6 IL1B CXCL8
29
Glucocorticoid receptor regulatory network 1
11.86 SELE IL6 ICAM1 CXCL8
30
Th1 Differentiation Pathway 64
Show member pathways
 11.82 TNF TLR2 IL6 IL1B
31
Pertussis 36
11.82 TNF IL6 IL1B CXCL8
32
Rheumatoid arthritis 36
11.77 VEGFA TNF TLR2 IL6 IL1B ICAM1
33
Dendritic Cells Developmental Lineage Pathway 64
11.76 TNF IL6 IL1B
34
IgA-Producing B Cells in the Intestine 64
11.73 TNF TLR2 IL6 ICAM1
35
Lung fibrosis 1
11.69 TNF IL6 IL1B CXCL8
36
Legionellosis 36
11.63 TNF TLR2 IL6 IL1B CXCL8
37
ATF-2 transcription factor network 1
11.62 SELE IL6 CXCL8
38
Hepatitis C and Hepatocellular Carcinoma 1
11.58 VEGFA IL6 CXCL8
39
MSP-RON Signaling 63
11.55 TNF TLR2 IL1B
40
Interleukin-10 signaling 65
11.54 TNF IL6 IL1B ICAM1 CXCL8
41
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.52 TNF IL6 IL1B
42
amb2 Integrin signaling 1
11.51 TNF PLG IL6 ICAM1 HMGB1
43
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 VEGFA TNF SELE IL6 IL1B ICAM1
44
IL-10 Pathway 63
11.4 TNF IL6 IL1B
45
Development and heterogeneity of the ILC family 1
11.36 TNF IL6 IL1B
46
Antifolate resistance 36
11.34 TNF IL6 IL1B
47
Cytokines and Inflammatory Response 1
11.31 TNF IL6 IL1B
48
African trypanosomiasis 36
11.29 TNF SELE IL6 IL1B ICAM1
49
IL1 and megakaryocytes in obesity 1
11.24 TLR2 IL1B ICAM1
50
AGE-RAGE signaling pathway in diabetic complications 36
11.23 VEGFB VEGFA TNF SELE IL6 IL1B
Sources

GO Terms for Endophthalmitis

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Cellular components related to Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 VEGFA TNF TLR2 PLG LGALS1 ICAM1
2 extracellular region GO:0005576 9.8 VEGFB VEGFA TNF PRF1 PLG PGF
3 extracellular space GO:0005615 9.5 VEGFB VEGFA TNF SELE PLG PGF
4 platelet alpha granule lumen GO:0031093 9.46 VEGFB VEGFA PLG ALB

Biological processes related to Endophthalmitis according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.34 VEGFB VEGFA TLR2 SAG PGF IL6
2 immune response GO:0006955 10.11 TNF TLR2 IL6 IL1B DEFB1 CXCL8
3 negative regulation of cell proliferation GO:0008285 10.1 TLR2 PLG IL6 IL1B CXCL8
4 positive regulation of gene expression GO:0010628 10.07 VEGFA TNF TLR2 IL6 IL1B CXCL8
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.02 VEGFB VEGFA TNF ICAM1 HMGB1
6 cellular protein metabolic process GO:0044267 10.01 PLG LGALS1 IL6 ALB
7 cytokine-mediated signaling pathway GO:0019221 10.01 VEGFA TNF IL6 IL1B ICAM1 CXCL8
8 response to lipopolysaccharide GO:0032496 9.98 TLR2 SELE IL1B ICAM1
9 response to hypoxia GO:0001666 9.97 VEGFB VEGFA TLR2 PGF ICAM1
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.97 TNF TLR2 IL6 IL1B ICAM1
11 positive regulation of angiogenesis GO:0045766 9.95 VEGFB VEGFA PGF IL1B CXCL8
12 platelet degranulation GO:0002576 9.94 VEGFB VEGFA PLG ALB
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.93 VEGFB VEGFA IL6 ICAM1
14 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR2 IL6 HMGB1 CARD9
15 positive regulation of JNK cascade GO:0046330 9.91 TNF IL1B HMGB1 CARD9
16 regulation of insulin secretion GO:0050796 9.89 TNF IL6 IL1B
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 VEGFA TNF IL6
18 positive regulation of endothelial cell proliferation GO:0001938 9.88 VEGFB VEGFA PGF
19 cellular response to organic cyclic compound GO:0071407 9.88 TNF LGALS1 IL1B
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF TLR2 IL1B HMGB1
21 positive regulation of protein phosphorylation GO:0001934 9.88 VEGFB VEGFA TNF PGF IL1B HMGB1
22 response to glucocorticoid GO:0051384 9.87 TNF IL6 HMGB1
23 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.87 VEGFB VEGFA PGF
24 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 HMGB1
25 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.85 TNF HMGB1 CARD9
26 positive regulation of nitric oxide biosynthetic process GO:0045429 9.85 TNF IL1B ICAM1
27 cellular response to lipopolysaccharide GO:0071222 9.85 TNF IL6 IL1B ICAM1 HMGB1 CXCL8
28 positive regulation of chemokine production GO:0032722 9.84 TNF TLR2 IL6
29 positive regulation of interleukin-10 production GO:0032733 9.83 TLR2 IL6 HMGB1
30 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 TNF TLR2 IL1B
31 sprouting angiogenesis GO:0002040 9.82 VEGFB VEGFA PGF
32 negative regulation of neurogenesis GO:0050768 9.81 TNF IL6 IL1B
33 positive regulation of cell division GO:0051781 9.81 VEGFB VEGFA PGF IL1B
34 positive regulation of glial cell proliferation GO:0060252 9.78 TNF IL6 IL1B
35 positive chemotaxis GO:0050918 9.78 VEGFB VEGFA PGF HMGB1
36 vascular endothelial growth factor signaling pathway GO:0038084 9.77 VEGFB VEGFA PGF
37 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.77 TNF IL6 ICAM1
38 inflammatory response GO:0006954 9.76 TNF TLR2 SELE IL6 IL1B HMGB1
39 positive regulation of neuroinflammatory response GO:0150078 9.73 TNF IL6 IL1B
40 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.72 TNF HMGB1
41 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.72 VEGFA PLG
42 positive regulation of interleukin-8 production GO:0032757 9.72 TNF TLR2 IL6 IL1B HMGB1
43 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
44 endothelial cell chemotaxis GO:0035767 9.7 VEGFA HMGB1
45 response to peptidoglycan GO:0032494 9.69 IL6 CARD9
46 positive regulation of dendritic cell differentiation GO:2001200 9.68 LGALS1 HMGB1
47 positive regulation of fever generation GO:0031622 9.67 TNF IL1B
48 sequestering of triglyceride GO:0030730 9.67 TNF IL1B
49 negative regulation of lipid storage GO:0010888 9.67 TNF IL6 CRP
50 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.65 TNF IL1B

Molecular functions related to Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.32 VEGFB VEGFA TNF TLR2 SELE SAG
2 cytokine activity GO:0005125 9.73 VEGFA TNF IL6 IL1B HMGB1 CXCL8
3 growth factor activity GO:0008083 9.71 VEGFB VEGFA PGF IL6
4 chemoattractant activity GO:0042056 9.46 VEGFB VEGFA PGF HMGB1
5 vascular endothelial growth factor receptor 1 binding GO:0043183 9.37 VEGFB VEGFA
6 identical protein binding GO:0042802 9.36 VEGFB VEGFA TNF TLR2 PRF1 LGALS1
7 vascular endothelial growth factor receptor binding GO:0005172 9.13 VEGFB VEGFA PGF
Sources

Sources for Endophthalmitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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