MCID: END047
MIFTS: 53

Endophthalmitis

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Endophthalmitis

MalaCards integrated aliases for Endophthalmitis:

Name: Endophthalmitis 12 58 54 43 15 71

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:4692
MeSH 43 D009877
NCIt 49 C34586
SNOMED-CT 67 1847009
ICD10 32 H45.1
MESH via Orphanet 44 D009877
ICD10 via Orphanet 33 H44.0 H44.1
UMLS via Orphanet 72 C0014236
Orphanet 58 ORPHA199323
UMLS 71 C0014236

Summaries for Endophthalmitis

Disease Ontology : 12 A globe disease that is characterized by inflammation of the inside of the eye.

MalaCards based summary : Endophthalmitis is related to acute endophthalmitis and chronic endophthalmitis, and has symptoms including redness or discharge of eye An important gene associated with Endophthalmitis is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Human cytomegalovirus infection. The drugs Cefazolin and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 74 Endophthalmitis is an inflammation of the interior of the eye. It is a possible complication of all... more...

Related Diseases for Endophthalmitis

Diseases in the Endophthalmitis family:

Chronic Endophthalmitis Acute Endophthalmitis

Diseases related to Endophthalmitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 882)
# Related Disease Score Top Affiliating Genes
1 acute endophthalmitis 34.6 VEGFA PRF1 ASPRV1
2 chronic endophthalmitis 34.6 MRAP ASPRV1
3 purulent endophthalmitis 34.6 VEGFA PRF1 ASPRV1
4 sympathetic ophthalmia 31.9 TNF SELE ICAM1
5 retinal detachment 31.5 VEGFA TNF IL6 HMGB1
6 panuveitis 31.3 TNF SAG MRAP IL6 CRP
7 cataract 31.3 VEGFA TNF IL6 ICAM1 CRYAA CRP
8 neuroretinitis 31.2 SAG MRAP CRP
9 hypopyon 30.9 VEGFA TNF MRAP IL6 CRP ASPRV1
10 uveitis 30.9 TNF SAG IL6 IL1B ICAM1 CRYAA
11 retinal vasculitis 30.9 TNF SAG MRAP
12 endocarditis 30.8 TNF TLR2 IL6 CRP
13 haemophilus influenzae 30.8 TNF TLR2
14 scleritis 30.8 TNF SELE MRAP CRP
15 chorioretinitis 30.7 VEGFA TNF SAG MRAP IL6
16 microvascular complications of diabetes 5 30.7 VEGFA PLG PGF ICAM1 CRYAA
17 vitreous detachment 30.7 VEGFB VEGFA PLG
18 conjunctivitis 30.7 TNF PLG IL6 ICAM1
19 macular holes 30.7 VEGFA PLG CRYAA
20 erythema multiforme 30.6 TNF IL6 ICAM1
21 retinal vein occlusion 30.6 VEGFA TNF IL6 IL1B
22 keratitis, hereditary 30.6 VEGFA TNF TLR2 IL6 IL1B CRYAA
23 vasculitis 30.6 TNF SELE IL6 ICAM1 CRP
24 cellulitis 30.6 TNF IL6 IL1B CRP
25 iritis 30.6 TNF MRAP IL6 CRP
26 iridocyclitis 30.5 VEGFA TNF MRAP IL6 CRP ASPRV1
27 diabetic macular edema 30.5 VEGFB VEGFA PGF IL6 ICAM1
28 blastomycosis 30.5 TNF IL6 CARD9
29 choroiditis 30.5 VEGFA TNF SAG MRAP
30 kuhnt-junius degeneration 30.5 VEGFB VEGFA PLG PGF CRYAA
31 infective endocarditis 30.4 TNF TLR2 IL6 CRP
32 severe cutaneous adverse reaction 30.4 TNF PRF1 CRP
33 keratoconjunctivitis 30.4 TNF IL6 ICAM1
34 intermediate uveitis 30.4 TNF MRAP IL6
35 aspergillosis 30.3 TNF TLR2 IL6 IL1B
36 posterior uveitis 30.3 TNF SAG MRAP IL6
37 osteomyelitis 30.3 TNF TLR2 IL6 IL1B
38 hydrocele 30.3 VEGFA SELE ICAM1
39 exudative vitreoretinopathy 1 30.2 VEGFB VEGFA PGF IL1B CRYAA
40 central retinal vein occlusion 30.2 VEGFA PLG PGF IL6
41 spondylitis 30.2 TNF IL6 CRP
42 acute pyelonephritis 30.2 PGF IL6 CRP
43 candidiasis 30.2 TNF TLR2 IL6 IL1B DEFB1 CARD9
44 blepharitis 30.2 TNF IL6 IL1B
45 branch retinal artery occlusion 30.2 VEGFA PLG CRYAA CRP
46 fasciitis 30.2 TNF IL6 CRP
47 acute cystitis 30.2 TNF TLR2 IL6 IL1B CRP
48 herpes zoster 30.1 TNF TLR2 CRP
49 neovascular glaucoma 30.1 VEGFB VEGFA PLG PGF CRYAA
50 rubeosis iridis 30.1 VEGFA PLG

Graphical network of the top 20 diseases related to Endophthalmitis:



Diseases related to Endophthalmitis

Symptoms & Phenotypes for Endophthalmitis

UMLS symptoms related to Endophthalmitis:


redness or discharge of eye

MGI Mouse Phenotypes related to Endophthalmitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.34 CARD9 CRP ICAM1 IL1B IL6 LGALS1
2 cardiovascular system MP:0005385 10.23 CRP ICAM1 IL1B IL6 PGF PLG
3 immune system MP:0005387 10.22 CARD9 CRP ICAM1 IL1B IL6 LGALS1
4 integument MP:0010771 10.15 ASPRV1 ICAM1 IL1B IL6 LGALS1 PGF
5 liver/biliary system MP:0005370 9.92 IL6 MRAP PLG PRF1 SELE TLR2
6 neoplasm MP:0002006 9.91 ICAM1 IL1B IL6 PGF PLG PRF1
7 nervous system MP:0003631 9.9 ICAM1 IL1B IL6 LGALS1 PLG PRF1
8 respiratory system MP:0005388 9.61 IL6 LGALS1 MRAP PGF PLG SELE
9 vision/eye MP:0005391 9.28 ICAM1 IL6 PGF PLG SAG SELE

Drugs & Therapeutics for Endophthalmitis

Drugs for Endophthalmitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Phase 4 25953-19-9 656510 33255
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
4
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
5
Vancomycin Approved Phase 4 1404-90-6 14969 441141
6
Iodine Approved, Investigational Phase 4 7553-56-2 807
7
Povidone-iodine Approved Phase 4 25655-41-8
8
Povidone Approved Phase 4 9003-39-8
9
Bevacizumab Approved, Investigational Phase 4 216974-75-3
10
Gatifloxacin Approved, Investigational Phase 4 112811-59-3 5379
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
13
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
14
Polyestradiol phosphate Approved Phase 4 28014-46-2
15
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
16
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
17
Ranibizumab Approved Phase 4 347396-82-1 459903
18
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
19
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
20
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
21
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
22 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
23
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
24
Bromfenac Approved Phase 4 91714-94-2 60726
25
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
26
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
27 Sodium Channel Blockers Phase 4
28 Cephalosporins Phase 4
29 Anti-Arrhythmia Agents Phase 4
30 Anesthetics, Local Phase 4
31 Diuretics, Potassium Sparing Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Hormones Phase 4
34 Hormone Antagonists Phase 4
35 glucocorticoids Phase 4
36 Anti-Inflammatory Agents Phase 4
37 Clindamycin phosphate Phase 4
38 Clindamycin palmitate Phase 4
39 Gentamicins Phase 4
40 Norgestimate, ethinyl estradiol drug combination Phase 4
41 cadexomer iodine Phase 4
42 Anti-Infective Agents, Local Phase 4
43 Plasma Substitutes Phase 4
44 Blood Substitutes Phase 4
45 Angiogenesis Inhibitors Phase 4
46 Anesthetics Phase 4
47 Estradiol 17 beta-cypionate Phase 4
48 Contraceptive Agents Phase 4
49 Estradiol 3-benzoate Phase 4
50 Contraceptives, Oral, Combined Phase 4

Interventional clinical trials:

(show top 50) (show all 126)
# Name Status NCT ID Phase Drugs
1 Cefazolin-Lidocaine Solution for Reducing Pain Associated With Subconjunctival Antibiotic Prophylaxis in Vitreo-Retinal Surgery Unknown status NCT02324166 Phase 4 Cefazolin;Lidocaine
2 Intravitreal Diclofenac Versus Intravitreal Ranibizumab for the Treatment of Diabetic Macular Edema. Unknown status NCT03458923 Phase 4 Diclofenac Sodium 0.1 ml containing 500µg;Ranibizumab 0.5 mg Solution for Injection
3 Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis Completed NCT00398658 Phase 4 gentamycin and clindamycin
4 Comparative Efficacy of Two Different Regimens of Povidone-iodine 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora Completed NCT01739920 Phase 4
5 Postoperative Safety Outcomes in Patients Undergoing Routine Phacoemulsification Cataract Surgery With Intraoperative Intracameral Injection of Preservative-Free Moxifloxacin Versus Levofloxacin Completed NCT04403334 Phase 4 Levofloxacin Ophthalmic;Moxifloxacin Ophthalmic
6 Prospective, Randomized, Double-blind Comparison of 5 % Against 1.25 % Povidone-iodine Solution as Preoperative Antisepsis for Strabismus Surgery in Young Children Completed NCT00461656 Phase 4 Preoperative conjunctival irrigation with 5% or 1.25% PI
7 Phase 4 Study on Effectiveness of Topical 0.5% Levofloxacin on Reduction of Preoperative Conjunctival Flora in Patients Scheduled for Intraocular Surgery Completed NCT00491049 Phase 4 0.5% levofloxacin eye drops
8 Povidone Iodine vs AVEnova: A Pre-injection Disinfection Study (PAVE Study) Completed NCT04018482 Phase 4
9 To Compare the Efficacy of Topical Vigamox Eye Drops at Tid 3 Days Prior to Intravitreal Injection Versus Tid 1 Day Prior to Intravitreal Injection Completed NCT00690313 Phase 4 Vigamox
10 A Two Different Chemoprophylaxis Approaches After Phacoemulsification Surgery in One Thousand Patients in Iraq :a Clinical Trial Completed NCT03634852 Phase 4 Moxifloxacin hydrochloride 0.5% eye drops;Dexamethasone 0.1% eye drops;Intracameral Moxifloxacin 0.1%;Subconjunctival Triamcinolone acetonide 4 mg /0.4 ml
11 Dropless™ vs. Less Drops™ Pharmaceutical Regimens After Cataract Surgery Completed NCT02819908 Phase 4 Imprimis Dropless;Imprimis Less Drops
12 Lessdrops™ Prophylactic Treatment After Routine Phacoemulsification Compared to Standard Drops Regimen Completed NCT03578276 Phase 4 Pred-Gati-Brom;Prednisolone acetate 1% ophthalmic suspension;Gatifloxacin Ophthalmic;Bromfenac 0.075% Oph Solution
13 Evaluation on Efficacy of Topical Nepafenac as Supplement Therapy in the Treatment of Diabetic Macular Edema Completed NCT02443012 Phase 4 Topical Gutt Nepafenac 0.1%
14 Prospective Randomized Controlled Study of Intravitreal Injection of 0.16 mg Bevacizumab One Day Before Surgery for Proliferative Diabetic Retinopathy Completed NCT01854593 Phase 4 Bevacizumab
15 Comparison of Dropless Prophylaxis After Routine Phacoemulsification to Standard Drops Regimen Completed NCT02515045 Phase 4 TriMoxiVanc;Moxifloxacin HCl 0.5%;Ilevro;Prednisolone acetate 1%
16 Evaluation of the Effect of Repeated Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using Optical Coherence Tomography Angiography Completed NCT03246152 Phase 4 Bevacizumab
17 A Study to Investigate the Safety and Efficacy of Lucentis (Ranibizumab) in Patients With CNV Due to Causes Other Than AMD and in Patients Where Pigment Epithelial Detachments Are the Primary Manifestation of Their AMD. Completed NCT01628354 Phase 4 Ranibizumab
18 Prospective, Single-center, Six-month Study of Intravitreal Ranibizumab for Macular Edema With Nonproliferative Diabetic Retinopathy: Effects on Microaneurysm Turnover and Non-perfused Retinal Area Completed NCT02834663 Phase 4 Lucentis
19 Intravitreal Aflibercept (VEGF Trap-Eye) in Neovascular Age-related Macular Degeneration With Limited Response to Ranibizumab Completed NCT02309281 Phase 4 aflibercept 2mg
20 A Phase IV OpenLabelled Prospective Pilot Study of Intravitreal Macugen (Pegaptanib) for Ischaemic Diabetic Macular Oedema (MIDME Study) Completed NCT01175070 Phase 4 Intravitreal injection of pegaptanib sodium
21 Evaluation and Comparison of Macular and Choroidal Thickness After Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis Recruiting NCT03363295 Phase 4 Moxifloxacin Injection
22 A Multicenter Study Comparing Efficacy and Safety of " Treat-and-Extend" Regimen Versus "Pro Re Nata" Regimen of Conbercept in Neovascular Age-related Macular Degeneration Active, not recruiting NCT02802657 Phase 4 Conbercept
23 Randomized, Double Blind, Controlled Study With Verteporfin Photodynamic Therapy And Intravitreal Triamcinolone(IVTA) Vs Triple Therapy With Verteporfin Photodynamic Therapy, Intravitreal Triamcinolone And Intravitreal Ranibizumab In Patients With Subfoveal Choroidal Neovascularization(CNV) Secondary To Age-Related Macular Degeneration(AMD) Unknown status NCT00930189 Phase 2, Phase 3 intravitreal injection of ranibizumab;intravitreal injection of triamcinolone
24 Efficacy and Safety of Intravitreal Triamcinolone as Treatment of the Diffuse Diabetic Macular Edema Unknown status NCT00309192 Phase 3 Triamcinolone Acetonide 4 mg intravitreal injection
25 A Randomized, Prospective, Double Masked Clinical Trial of Life 4°C Versus Optisol GS Corneal Storage Media Unknown status NCT01657500 Phase 3
26 Interest of Intravitreal Corticotherapy as the First-line Treatment for Post-operative Endophthalmitis. Completed NCT01768078 Phase 3
27 Endophthalmitis Vitrectomy Study (EVS) Completed NCT00000130 Phase 3 Intravitreal Antibiotics
28 Retaane® in Age-Related Macular Degeneration Completed NCT00569569 Phase 2, Phase 3 juxtascleral depot injection of Retaane
29 Clinical Study for Evaluating the Safety and Clinical Effectiveness of Intravitreal Bevacizumab (Lumiere®) in Patients With Wet Age-related Macular Degeneration. Completed NCT03668054 Phase 3 Bevacizumab (Lumiere®)
30 Systemic Bevacizumab (Avastin) Therapy for Exudative Neovascular Age-Related Macular Degeneration Completed NCT00531024 Phase 2, Phase 3 Bevacizumab;Sodium Chloride
31 Intravitreal Bevacizumab and Intravitreal Triamcinolone Associated to Laser Photocoagulation for Diabetic Macular Edema(IBeTA) Completed NCT00997191 Phase 3 Intravitreal triamcinolone;Intravitreal bevacizumab
32 The Standard Care vs. Corticosteroid for Retinal Vein Occlusion (SCORE) Study Completed NCT00106132 Phase 3 Triamcinolone Acetonide
33 An Evaluation of Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy Completed NCT00996437 Phase 2, Phase 3 Ranibizumab;Saline
34 Safety and Efficacy of Intracameral Zimoxin (0.1% Moxifloxacin Solution) for Prevention of Endophthalmitis After Cataract Surgery Not yet recruiting NCT03244072 Phase 2, Phase 3 Moxifloxacin;Placebo
35 Intracameral Antibiotic Safety Study Not yet recruiting NCT02590523 Phase 3 Vancomycin;Moxifloxacin;Placebo
36 Use of Intracameral Moxifloxacin for the Prevention of Acute Endophthalmitis Following Cataract Surgery: a Controlled and Randomized Clinical Trial Terminated NCT02770729 Phase 3 Moxifloxacin;No injection of moxifloxacin
37 Prospective Randomized Controlled Trial of Trabectome Versus Trabeculectomy With Mitomycin C in Patients With Open Angle Glaucoma Terminated NCT00901108 Phase 3
38 The Effect of Intravitral Injection of Triamcinolone Combined With Cataract Surgery (Phacoemulsification) on Diabetic Macular Edema and Diabetic Retinopathy Unknown status NCT00849537 Phase 1, Phase 2 Triamcinolone
39 Combined Posterior Sub-Tenon Injection of Triamcinolone Acetonide and Laser Photocoagulation for the Treatment of Clinically Significant Macular Edema Unknown status NCT00229918 Phase 2 triamcinolone acetonide
40 Does Hyperbaric Chamber Improve the Functionality and Symptoms Related to Central Retinal Vein Occlusion (CRVO)? Unknown status NCT02405741 Phase 2
41 Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis Completed NCT02595359 Phase 2 Moxifloxacin
42 Combination Ranibizumab and Bromfenac for Neovascular Age-related Macular Degeneration Completed NCT00805233 Phase 2 combination ranibizumab + bromfenac;ranibizumab injection alone
43 Ranibizumab and Reduced Fluence Photodynamic Therapy for Choroidal Neovascularization in Age Related Macular Degeneration Completed NCT00527475 Phase 2 ranibizumab;verteporfin
44 Comparative Study of the Efficacy and Safety of Ologen Collagen Implant Versus Cohesive Viscoelastic in Trabeculectomy Performed for Steroid Induced Glaucoma Completed NCT01912638 Phase 1, Phase 2 Provisc
45 An Open Label, Multicenter, Randomized, Uncontrolled Study Assessing the Safety and Efficacy of KH902 in Patients With Choroidal Neovascularization Due to Neovascular Age-related Macular Degeneration(HOPE Study) Completed NCT01242254 Phase 1, Phase 2
46 The Clinical Safety of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5% Recruiting NCT04212429 Phase 1, Phase 2 Levofloxacin Ophthalmic Product;Moxifloxacin Ophthalmic Solution
47 Intracameral Levofloxacin (0.5%) Versus Intracameral Cefuroxime (1mg/0.1ml) Effect on Corneal Endothelial Cell Count and Morphology in Uneventful Phacoemulsification Recruiting NCT04212078 Phase 1, Phase 2 Levofloxacin Ophthalmic;Cefuroxime
48 The Pharmacokinetics of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5% Recruiting NCT04214821 Phase 1, Phase 2 Levofloxacin Ophthalmic Solution;Moxifloxacin Ophthalmic Solution
49 Phase 2 Ziv-aflibercept in Ocular Disease Short and Long-term Study Recruiting NCT02486484 Phase 2 ziv-aflibercept
50 Phase I/II Comparative Study of a Single Intraoperative Sub-Tenon's Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System Versus 1% Prednisolone and 0.3% Ciprofloxacin Eyedrops for Cataract Surgery Terminated NCT00431028 Phase 1, Phase 2

Search NIH Clinical Center for Endophthalmitis

Cochrane evidence based reviews: endophthalmitis

Genetic Tests for Endophthalmitis

Anatomical Context for Endophthalmitis

MalaCards organs/tissues related to Endophthalmitis:

40
Eye, Endothelial, Liver, Testes, Retina, Lung, Colon

Publications for Endophthalmitis

Articles related to Endophthalmitis:

(show top 50) (show all 7991)
# Title Authors PMID Year
1
Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis. 54 61
9423880 1998
2
Virulence of enterococci. 61 54
7834601 1994
3
Criteria for intravitreal antibiotics during surgical removal of intraocular foreign bodies. 61 54
1286707 1992
4
Candida auris and endogenous panophthalmitis: clinical and histopathological features. 61
32462100 2020
5
Epidemiology and Outcomes Following Open Globe Injury in Agricultural Region, an 11-Year Experience. 61
31994961 2020
6
Eye-Related Emergency Department Visits and The Opioid Epidemic: a 10-Year Analysis. 61
32223491 2020
7
Prophylaxis measures for postinjection endophthalmitis. 61
31923477 2020
8
EFFICACY AND SAFETY OF A TREAT-AND-EXTEND REGIMEN WITH AFLIBERCEPT IN TREATMENT-NAIVE PATIENTS WITH TYPE 3 NEOVASCULARIZATION: A 52-Week, Single-Arm, Multicenter Trial. 61
31259813 2020
9
A survey exploring ophthalmologists' attitudes and beliefs in performing Immediately Sequential Bilateral Cataract Surgery in the United Kingdom. 61
32487105 2020
10
Bilateral endophthalmitis following bilateral same-day anti-VEGF injections. 61
32533656 2020
11
[Bilateral endogenous endophthalmitis in the intensive care unit]. 61
32461188 2020
12
Pasteurella multocida-induced endophthalmitis after a cat scratch. 61
32322756 2020
13
Toll-like receptors in acute post-cataract surgery endophthalmitis. 61
32507952 2020
14
Endogenous endophthalmitis during pregnancy: Case report. 61
32553803 2020
15
Endogenous endophthalmitis and bilateral optic neuropathy secondary to Mycobacterium bovis. 61
31879069 2020
16
Colon Adenocarcinoma Associated With Clostridium Septicum Endophthalmitis Detected on 18F-FDG PET/CT. 61
32332308 2020
17
Infectious Endophthalmitis in the Current Era. 61
32507272 2020
18
Listeria monocytogenes, a rare cause of endophthalmitis. 61
32397694 2020
19
Intravitreal aflibercept for management of choroidal neovascularization secondary to angioid streaks: The Italian EYLEA-STRIE study. 61
32483995 2020
20
Posterior hypopyon in fungal endogenous endophthalmitis secondary to presumably contaminated dextrose infusion. 61
32373756 2020
21
Delayed-onset bleb-related endophthalmitis caused by Moraxella nonliquefaciens. 61
32561182 2020
22
Open globe injuries in children under 7 years referred to a tertiary center in Iran from 2006 to 2016. 61
32572182 2020
23
Bacterial contamination of intravitreal needles by the ocular surface microbiome. 61
32497656 2020
24
Coccidioidal Endophthalmitis: Excellent Recovery of Vision with Aggressive Use of Intravitreal Antifungals and Vitrectomy. 61
32541432 2020
25
A Nine-Year Analysis of Practice Patterns, Microbiologic Yield, and Clinical Outcomes in Cases of Presumed Infectious Endophthalmitis. 61
32387054 2020
26
Endophthalmitis after strabismus surgery: incidence and outcome in relation to age, operated eye muscle, surgical technique, scleral perforation and immune state. 61
32533628 2020
27
A Novel Vitreous Culture Technique. 61
32541443 2020
28
Are high-efficiency particulate air (HEPA) filters and laminar air flow necessary in operating rooms to control acute post-operative endophthalmitis? 61
32461444 2020
29
Predictive factors of enucleation after open globe injuries. 61
32567040 2020
30
Pre-operative conjunctival flora in patients with local and/or systemic risk factors for post cataract surgery infection in Northern Italy. 61
32552180 2020
31
Asymmetric retinopathy of prematurity in presumed fungal endophthalmitis. 61
32382688 2020
32
Quantitative Ocular Ultrasound Findings in Microbial Keratitis-Associated Endophthalmitis. 61
32147489 2020
33
Therapeutic penetrating keratoplasty for microbial keratitis in Taiwan from 2001 to 2014. 61
31635845 2020
34
Rapidly progressive streptococcus dysgalactiae corneal ulceration associated with erlotinib use in stage IV lung cancer. 61
32140616 2020
35
Short-Term Clinical Outcomes of a Novel Corneal Prosthetic Device in a Rabbit Model. 61
31990845 2020
36
Postoperative complications in Medicare beneficiaries following endothelial keratoplasty (EK) surgery. 61
32574781 2020
37
Twenty years of endophthalmitis: Incidence, aetiology and clinical outcome. 61
32567150 2020
38
Polymicrobial infection confined to Ahmed glaucoma shunt. 61
32195438 2020
39
Posterior segment complications following glaucoma surgeries. 61
32461411 2020
40
A case report of fulminant endophthalmitis caused by Streptococcus dysgalactiae in a patient with traumatic corneal laceration. 61
32552664 2020
41
Simple Technique for Transscleral Fixation of a Foldable Posterior Chamber Intraocular Lens Using a Single Suture. 61
30884995 2020
42
Characteristics of paediatric patients hospitalised for eye trauma in 2007-2015 and factors related to their visual outcomes. 61
32518396 2020
43
Ciprofloxacin Loaded Nanostructured Lipid Carriers Incorporated into In-Situ Gels to Improve Management of Bacterial Endophthalmitis. 61
32575524 2020
44
The first case of fungal endogenous endophthalmitis caused by Aspergillus nidulans: Diagnostic and therapeutic challenge. 61
32486857 2020
45
Intraocular foreign body injury in children: clinical characteristics and factors associated with endophthalmitis. 61
31554633 2020
46
Clinical Course and Characteristics of Eyes that Developed Recurrent Episodes of Endophthalmitis. 61
32544624 2020
47
CLINICAL UTILITY OF BETA-D-GLUCAN TESTING FOR ENDOGENOUS FUNGAL CHORIORETINITIS OR ENDOPHTHALMITIS. 61
32516224 2020
48
Toward a chimeric vaccine against multiple isolates of Mycobacteroides - An integrative approach. 61
32169520 2020
49
Unilateral acute iris depigmentation and transillumination after glaucoma surgery with mitomycin application and intracameral moxifloxacin. 61
32154439 2020
50
Prompt vitrectomy for management of endophthalmitis in setting of unexposed glaucoma drainage implant. 61
32274446 2020

Variations for Endophthalmitis

Expression for Endophthalmitis

Search GEO for disease gene expression data for Endophthalmitis.

Pathways for Endophthalmitis

Pathways related to Endophthalmitis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 VEGFB VEGFA TNF TLR2 PGF IL6
2
Show member pathways
12.92 VEGFA TNF TLR2 IL6 IL1B ICAM1
3
Show member pathways
12.83 VEGFA TNF PRF1 IL6 IL1B ICAM1
4 12.79 TNF TLR2 IL6 IL1B CARD9
5
Show member pathways
12.79 TNF TLR2 PLG IL6 IL1B ICAM1
6 12.75 VEGFB VEGFA TNF PGF IL1B
7
Show member pathways
12.71 TNF TLR2 IL6 IL1B CARD9
8
Show member pathways
12.66 VEGFB TNF TLR2 PGF IL6 IL1B
9 12.55 TNF TLR2 LGALS1 IL1B CARD9
10
Show member pathways
12.32 TNF TLR2 IL6 IL1B
11 12.3 TNF TLR2 IL6 IL1B
12
Show member pathways
12.25 VEGFB TNF PGF IL6 IL1B
13 12.23 TNF IL6 IL1B CARD9
14
Show member pathways
12.21 TNF IL6 IL1B CARD9
15
Show member pathways
12.21 TNF PLG IL6 IL1B ICAM1 CRP
16 12.18 VEGFA TNF TLR2 IL6
17
Show member pathways
12.18 TNF TLR2 IL6 IL1B
18 12.18 TNF TLR2 IL6 IL1B CARD9
19 12.17 VEGFA TNF IL6 IL1B
20 12.04 VEGFA TNF SELE IL1B ICAM1
21 12 TNF IL6 IL1B ICAM1
22
Show member pathways
11.92 TNF TLR2 IL6 IL1B
23 11.91 VEGFA TNF IL6 IL1B ICAM1
24 11.89 TNF TLR2 IL6 IL1B
25 11.88 TNF SELE IL6 IL1B ICAM1
26 11.79 SELE IL6 ICAM1
27 11.75 TNF IL6 IL1B
28 11.74 TNF IL6 IL1B
29 11.7 VEGFA TNF TLR2 IL6 IL1B ICAM1
30 11.66 TNF IL6 IL1B
31 11.57 TNF TLR2 IL6 IL1B
32 11.52 TNF TLR2 IL1B
33 11.48 TNF IL6 IL1B
34 11.47 TNF IL6 IL1B ICAM1
35 11.45 TNF PLG IL6 ICAM1 HMGB1
36
Show member pathways
11.43 VEGFA TNF SELE IL6 IL1B ICAM1
37 11.35 TNF IL6 IL1B
38 11.31 TNF IL6 IL1B
39 11.29 TNF SELE IL6 IL1B ICAM1
40 11.28 TNF IL6 IL1B
41 11.24 TNF IL6 IL1B
42 11.17 VEGFB VEGFA TNF SELE IL6 IL1B
43 11.15 TLR2 IL1B ICAM1
44 11.13 TNF TLR2 SELE IL6 IL1B ICAM1
45 11.01 TNF IL6 CRP
46
Show member pathways
10.93 VEGFB VEGFA PGF
47 10.92 TNF IL1B ICAM1
48 10.65 VEGFB VEGFA

GO Terms for Endophthalmitis

Cellular components related to Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VEGFB VEGFA TNF PRF1 PLG PGF
2 cell surface GO:0009986 9.7 VEGFA TNF TLR2 PLG LGALS1 ICAM1
3 membrane raft GO:0045121 9.62 TNF TLR2 SELE ICAM1
4 extracellular space GO:0005615 9.44 VEGFB VEGFA TNF SELE PLG PGF
5 platelet alpha granule lumen GO:0031093 9.43 VEGFB VEGFA PLG

Biological processes related to Endophthalmitis according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.1 TNF TLR2 IL6 IL1B DEFB1
2 positive regulation of gene expression GO:0010628 10.09 VEGFA TNF TLR2 IL6 IL1B CRP
3 response to drug GO:0042493 10.04 VEGFB PGF LGALS1 ICAM1 CARD9
4 cytokine-mediated signaling pathway GO:0019221 10.02 VEGFA TNF IL6 IL1B ICAM1
5 leukocyte migration GO:0050900 9.98 TNF SELE IL1B ICAM1
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.97 TNF LGALS1 IL1B CARD9
7 positive regulation of protein phosphorylation GO:0001934 9.97 VEGFB VEGFA TNF PGF IL1B
8 response to lipopolysaccharide GO:0032496 9.96 TLR2 SELE IL1B ICAM1
9 cellular response to lipopolysaccharide GO:0071222 9.96 TNF IL6 IL1B ICAM1 HMGB1
10 positive regulation of angiogenesis GO:0045766 9.95 VEGFB VEGFA PGF IL1B
11 response to hypoxia GO:0001666 9.93 VEGFB VEGFA TLR2 PGF ICAM1
12 positive regulation of JNK cascade GO:0046330 9.9 TNF IL1B HMGB1 CARD9
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNF TLR2 IL6 IL1B ICAM1
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.87 VEGFA TNF IL6
15 positive regulation of endothelial cell proliferation GO:0001938 9.87 VEGFB VEGFA PGF
16 cellular response to organic cyclic compound GO:0071407 9.86 TNF LGALS1 IL1B
17 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.86 VEGFB VEGFA PGF
18 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.85 TNF HMGB1 CARD9
19 positive regulation of tumor necrosis factor production GO:0032760 9.84 TLR2 HMGB1 CARD9
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.82 TNF IL1B ICAM1
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 IL1B
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF TLR2 IL1B HMGB1
23 inflammatory response GO:0006954 9.8 TNF TLR2 SELE IL6 IL1B HMGB1
24 sprouting angiogenesis GO:0002040 9.79 VEGFB VEGFA PGF
25 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 IL1B
26 positive regulation of chemokine production GO:0032722 9.77 TNF TLR2 IL6
27 positive regulation of glial cell proliferation GO:0060252 9.76 TNF IL6 IL1B
28 vascular endothelial growth factor signaling pathway GO:0038084 9.74 VEGFB VEGFA PGF
29 positive chemotaxis GO:0050918 9.73 VEGFB VEGFA PGF HMGB1
30 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.72 TNF IL6 ICAM1
31 positive regulation of cell division GO:0051781 9.71 VEGFB VEGFA PGF IL1B
32 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.7 VEGFA PLG
33 induction of positive chemotaxis GO:0050930 9.7 VEGFB VEGFA PGF
34 regulation of establishment of endothelial barrier GO:1903140 9.68 TNF IL1B
35 response to peptidoglycan GO:0032494 9.68 IL6 CARD9
36 positive regulation of dendritic cell differentiation GO:2001200 9.67 LGALS1 HMGB1
37 positive regulation of interleukin-6 secretion GO:2000778 9.67 TNF TLR2 IL1B HMGB1
38 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
39 positive regulation of neuroinflammatory response GO:0150078 9.65 TNF IL6 IL1B
40 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B
42 negative regulation of lipid storage GO:0010888 9.63 TNF IL6 CRP
43 positive regulation of mast cell chemotaxis GO:0060754 9.5 VEGFB VEGFA PGF
44 positive regulation of interleukin-8 production GO:0032757 9.46 TNF TLR2 IL1B HMGB1
45 defense response to Gram-positive bacterium GO:0050830 9.43 TNF TLR2 IL6 DEFB1 CRP CARD9
46 positive regulation of interleukin-6 production GO:0032755 9.1 TNF TLR2 IL6 IL1B HMGB1 CARD9

Molecular functions related to Endophthalmitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 VEGFB VEGFA TNF TLR2 SELE PRF1
2 growth factor activity GO:0008083 9.67 VEGFB VEGFA PGF IL6
3 cytokine activity GO:0005125 9.65 VEGFA TNF IL6 IL1B HMGB1
4 chemoattractant activity GO:0042056 9.46 VEGFB VEGFA PGF HMGB1
5 identical protein binding GO:0042802 9.36 VEGFB VEGFA TNF TLR2 PRF1 PGF
6 vascular endothelial growth factor receptor 1 binding GO:0043183 9.32 VEGFB VEGFA
7 vascular endothelial growth factor receptor binding GO:0005172 9.13 VEGFB VEGFA PGF

Sources for Endophthalmitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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