Endotheliitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: END072 MIFTS: 36	Endotheliitis Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Endotheliitis

MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare eye diseases

External Ids:

Orphanet ⁵⁸ ORPHA137602

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Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to severe acute respiratory syndrome and pulmonary fibrosis, idiopathic. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Abacavir and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : ⁷³ Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

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Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)

#	Related Disease	Score	Top Affiliating Genes
1	severe acute respiratory syndrome	30.0	CXCL9 CXCL10
2	pulmonary fibrosis, idiopathic	29.0	CXCL9 CXCL10
3	corneal edema	10.6
4	herpes simplex	10.5
5	uveitis	10.4
6	iridocyclitis	10.4
7	chickenpox	10.4
8	keratitis, hereditary	10.3
9	bullous keratopathy	10.3
10	keratopathy	10.3
11	covid-19	10.2
12	cataract	10.1
13	ifap syndrome 2	10.1
14	neuroretinitis	10.1
15	retinitis	10.1
16	ocular hypertension	10.1
17	thrombosis	10.0
18	mumps	10.0
19	vascular disease	10.0
20	mansonelliasis	9.9	CXCL9 CXCL10
21	acrodermatitis	9.9	CXCL9 CXCL10
22	spotted fever	9.9	CXCL9 CXCL10
23	stroke, ischemic	9.9
24	human cytomegalovirus infection	9.9
25	corneal disease	9.9
26	parotitis	9.9
27	iritis	9.9
28	viral hepatitis	9.9
29	vasculitis	9.9
30	acanthamoeba keratitis	9.9
31	encephalopathy	9.9
32	paracoccidioidomycosis	9.9	CXCL9 CXCL10
33	viral encephalitis	9.9	CXCL9 CXCL10
34	encephalitis	9.9	CXCL9 CXCL10
35	proliferative glomerulonephritis	9.9	CXCL9 CXCL10
36	alopecia areata	9.9	CXCL9 CXCL10
37	trypanosomiasis	9.9	CXCL9 CXCL10
38	sarcoidosis 1	9.8	CXCL9 CXCL10
39	dermatitis	9.8	CXCL9 CXCL11
40	interstitial lung disease	9.8	CXCL9 CXCL10
41	polycystic echinococcosis	9.8	CXCL11 CXCL10
42	mycobacterium tuberculosis 1	9.8	CXCL9 CXCL10
43	cerebral amyloid angiopathy, cst3-related	9.8
44	autoimmune disease	9.8
45	facial spasm	9.8
46	hemifacial spasm, familial	9.8
47	retinoblastoma	9.8
48	sneddon syndrome	9.8
49	corneal endothelial dystrophy	9.8
50	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	9.8

Graphical network of the top 20 diseases related to Endotheliitis:

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Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-108	9.4	CXCL11
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.4	CXCL11
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-119	9.4	CXCL11
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-121	9.4	CXCL11
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.4	CXCL10
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-142	9.4	CXCL10
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-145	9.4	CXCL10
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.4	CXCL11
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-57	9.4	CXCL10
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.4	CXCL11
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-76	9.4	CXCL10
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-94	9.4	CXCL10

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Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 670)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Abacavir

Approved, Investigational

Phase 4

136470-78-5

65140 441300

Curcumin

Approved, Experimental, Investigational

Phase 4

458-37-7

969516

Olmesartan

Approved, Investigational

Phase 4

144689-24-7, 144689-63-4

158781 130881

Insulin glulisine

Approved

Phase 4

207748-29-6

Mineral oil

Approved, Vet_approved

Phase 4

8042-47-5

Naproxen

Approved, Vet_approved

Phase 4

22204-53-1

1302 156391

Certolizumab pegol

Approved

Phase 4

428863-50-7

Chromium

Approved

Phase 4

7440-47-3

27668

Cobalt

Approved, Experimental

Phase 4

7440-48-4

104729

Adenosine

Approved, Investigational

Phase 4

58-61-7

60961

Nitroprusside

Approved, Investigational

Phase 4

15078-28-1

11963622

Bevacizumab

Approved, Investigational

Phase 4

216974-75-3

Nebivolol

Approved, Investigational

Phase 4

152520-56-4, 118457-14-0, 99200-09-6

71301

Infliximab

Approved

Phase 4

170277-31-3

Paclitaxel

Approved, Vet_approved

Phase 4

33069-62-4

36314

Protein C

Approved

Phase 4

tannic acid

Approved

Phase 4

1401-55-4

Benzocaine

Approved, Investigational

Phase 4

1994-09-7, 94-09-7

2337

Tocopherol

Approved, Investigational

Phase 4

1406-66-2

Exenatide

Approved, Investigational

Phase 4

141758-74-9

15991534

Aspirin

Approved, Vet_approved

Phase 4

50-78-2

2244

Lactitol

Approved, Investigational

Phase 4

585-86-4

157355

Ezetimibe

Approved

Phase 4

163222-33-1

150311

Carvedilol

Approved, Investigational

Phase 4

72956-09-3

2585

Telmisartan

Approved, Investigational

Phase 4

144701-48-4

65999

Febuxostat

Approved

Phase 4

144060-53-7

134018

Dexmedetomidine

Approved, Vet_approved

Phase 4

113775-47-6

68602 5311068

Esomeprazole

Approved, Investigational

Phase 4

161796-78-7, 161973-10-0, 119141-88-7

9568614 4594

Ketoconazole

Approved, Investigational

Phase 4

65277-42-1

47576

Allopurinol

Approved

Phase 4

315-30-0

2094

Bosentan

Approved, Investigational

Phase 4

147536-97-8

104865

Linagliptin

Approved

Phase 4

668270-12-0

10096344

Efavirenz

Approved, Investigational

Phase 4

154598-52-4

64139

Emtricitabine

Approved, Investigational

Phase 4

143491-57-0

60877

Glyburide

Approved

Phase 4

10238-21-8

3488

Insulin glargine

Approved

Phase 4

160337-95-1

Insulin detemir

Approved

Phase 4

169148-63-4

5311023

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Dextromethorphan

Approved

Phase 4

125-71-3

5360696 5362449

Phenylpropanolamine

Approved, Vet_approved, Withdrawn

Phase 4

14838-15-4

26934

Fenofibrate

Approved

Phase 4

49562-28-9

3339

Acetaminophen

Approved

Phase 4

103-90-2

1983

Caffeine

Approved

Phase 4

58-08-2

2519

Benazepril

Approved, Investigational

Phase 4

86541-75-5

5362124

Pitavastatin

Approved

Phase 4

147511-69-1, 147526-32-7

6366718 5282452

Epoprostenol

Approved

Phase 4

61849-14-7, 35121-78-9

5280427 5282411

Vildagliptin

Approved, Investigational

Phase 4

274901-16-5

6918537

Irbesartan

Approved, Investigational

Phase 4

138402-11-6

3749

Drospirenone

Approved

Phase 4

67392-87-4

68873

Atenolol

Approved

Phase 4

29122-68-7

2249

Interventional clinical trials:

(show top 50) (show all 1657)

#	Name	Status	NCT ID	Phase	Drugs
1	To Compare the Efficacy of Monotherapy With Anti-Vascular Endothelial Growth Factor (Ranibizumab or Bevacizumab) Versus Combination Therapy With Anti-Vascular Endothelial Growth Factor and End-point-management Grid Laser Photocoagulation for Diabetic Macular Edema	Unknown status	NCT02462304	Phase 4	ranibizumab;Bevacizumab
2	Cilostazol Enhances the Number and Functions of Circulating Endothelial Progenitor Cells and Endothelial Function Mediated Through Modification of Vasculogenesis and Angiogenesis Factors in Patients With Stable Coronary Artery Disease	Unknown status	NCT02174939	Phase 4	Cilostazol;Dummy Placebo
3	Evaluate the Effect of Exenatide Treatment on Coronary Artery Endothelial Function	Unknown status	NCT02584075	Phase 4	Byetta (Exenatide);Glucophage ( Metformin Hydrochloride)
4	Effect of Gemigliptin or Acarbose on Endothelial Function in Type 2 DM Patients (GetUp Trial)	Unknown status	NCT02500329	Phase 4	Gemigliptin;Acarbose
5	Maraviroc Abacavir STudy - Effect on Endothelial Recovery	Unknown status	NCT01389063	Phase 4	Maraviroc
6	A Randomized, Observer-masked, Clinical Trial Comparing the Neusidl Corneal Inserter Corneal Transplant Technique to the Standard Forceps Insertion Technique for Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)	Unknown status	NCT01357122	Phase 4
7	Effect of Coreg CR on BP, Endothelial Function, Exhaled Nitric Oxide, and Nitric Oxide Production and Oxidation	Unknown status	NCT00732511	Phase 4	carvedilol;metoprolol extended release
8	Effect of Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor on Systemic and Renal Endothelial Function in Patients With Type 2 Diabetes Mellitus Without History of Coronary Artery Disease (SOCCER Trial)	Unknown status	NCT02501616	Phase 4	Metformin;Dapagliflozin
9	A Prospective Randomized Double Blind Study to Evaluate the Effect of Ticagrelor on Endothelial Function	Unknown status	NCT02261922	Phase 4	ticagrelor;prasugrel
10	Comparison of the Effects of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation in Patients With Prior Non-ST-segment Acute Coronary Syndrome	Unknown status	NCT02379676	Phase 4	Ticagrelor;Clopidogrel
11	Personalized Medicine in HCV Chronic Infection. Endothelial Dysfunction and Subclinical Atheromatosis in Patients With HCV Infection. Characterization and Potential Reversibility With Direct Antiviral Agents.	Unknown status	NCT02802280	Phase 4
12	Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study	Unknown status	NCT02651168	Phase 4
13	Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease	Unknown status	NCT00917527	Phase 4	Atorvastatin
14	Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients	Unknown status	NCT02933788	Phase 4	Cilostazol;Acetylsalicylic acid
15	Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis	Unknown status	NCT01752335	Phase 4
16	Telmisartan vs Ramipril for Reduction of Inflammation and Recruitment of Endothelial Progenitor Cells After Acute Coronary Syndrome	Unknown status	NCT00702936	Phase 4	TELMISARTAN;RAMIPRIL
17	Type 2 Diabetes Mellitus: Role of Inflammation and Innate Immunity in The Pathogenesis of Endothelial Dysfunction and Atherosclerosis	Unknown status	NCT01250340	Phase 4	Aspirin;Placebo
18	A TElmisartan and AMlodipine STudy to Assess the Cardiovascular PROTECTive Effects as Measured by Endothelial Dysfunction in Hypertensive at Risk Patients Beyond Blood Pressure	Unknown status	NCT01180205	Phase 4	Telmisartan;Amlodipine;Olmesartan medoxomil;Hydrochlorothiazide
19	Phase IV, Randomized, Open Label, Crossover, Intervention Trial to Investigate the Effect of the Switch of Lopinavir/Ritonavir to Raltegravir on Endothelial Function, Chronic Inflammation, Immune Activation and HIV Replication <50 Copies/ml	Unknown status	NCT01453933	Phase 4	raltegravir
20	Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers	Unknown status	NCT00526695	Phase 4	Sevoflurane (Preconditioning)
21	A Prospective, Randomized, Two Period, With an Intermediate Wash Out Period, Cross-over Study to Compare the Effects of Either Combined Therapy With Ramipril and Clopidogrel or Ramipril Monotherapy on Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Patients With Type 2 Diabetes and Diabetic Nephropathy	Unknown status	NCT01743014	Phase 4	Ramipril;Clopidogrel
22	Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease	Unknown status	NCT01595750	Phase 4	Roflumilast 500;Placebo
23	Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease	Unknown status	NCT01038050	Phase 4	Ginkgo Biloba Extract (GBE)
24	Changes in Central Aortic Pressure, Endothelial Function and Biomarkers in African Americans With Cardiometabolic Syndrome: Comparison of Amlodipine/Olmesartan Versus Hydrochlorothiazide/Losartan	Unknown status	NCT01271374	Phase 4	amlodipine and olmesartan;losartan and HCTZ
25	Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines	Unknown status	NCT02797028	Phase 4	Allopurinol
26	Effects of On-Line Hemodiafiltration(HDF) on Endothelial Dysfunction in Chronic Hemodialysis Patients	Unknown status	NCT00532597	Phase 4
27	Prospective Influence of Bedtime Insulin Glargine on Mobilization and Function of Endothelial Progenitor Cells in Patients With Type 2 Diabetes: a Partially Double-Blind, Randomized, Three-Arm Unicenter Study	Unknown status	NCT00523393	Phase 4	Insulin Glargin;Human Insulin
28	The Comparison of Endothelial Cell Count in Pterygium Surgery Relating to the Timing of MMC Application.	Unknown status	NCT02641132	Phase 4	Mitomycin C 0.02%
29	The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Gene Expression and Serum Levels of Some Inflammatory and Endothelial Factors in Migraine Patients	Unknown status	NCT02532023	Phase 4
30	Human Insulin Analogs: Evaluation of Inflammatory mRNA Expression of Macrophages and Endothelial Function of Short-acting Insulin - HERMES Pilot Study	Unknown status	NCT01417897	Phase 4	Insulin glulisine;Insulin aspart;Regular human insulin
31	A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES"	Unknown status	NCT01168700	Phase 4	aged garlic extract;Placebo
32	The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease	Unknown status	NCT01157260	Phase 4	Kremezin
33	Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure: Effects of Endothelial Progenitor Cells and a Direct Renin Inhibitor	Unknown status	NCT01156207	Phase 4	Aliskiren
34	Prospective, Randomized, Double - Blind Placebo Controlled Trial of Simvastatin and Resveratrol Therapy on Clinical, Endocrinological, Biochemical and Endothelial Dysfunction Parameters in Women With Polycystic Ovary Syndrome.	Unknown status	NCT02766803	Phase 4	Simvastatin and micronized trans-resveratrol
35	Early Re-Endothelialization Might Not be the Unique Solution to Prevent Restenosis. The EREMUS Study	Unknown status	NCT00870038	Phase 4
36	NSAIDs vs. Coxibs in the Presence of Aspirin: Effects on Platelet Function, Endothelial Function, and Biomarkers of Inflammation in Subjects With Rheumatoid Arthritis and Increased Cardiovascular Risk or Cardiovascular Disease	Unknown status	NCT03699293	Phase 4	celecoxib 200mg capsule;naproxen sodium 550mg tablet;Aspirin 81mg tablet
37	The Difference of Circulating Endothelial-derived and Platelet-derived Microparticles in Patients With Psoriasis Successfully Treated With Stelara(Ustekinumab)	Unknown status	NCT02693470	Phase 4	Ustekinumab
38	Use of Vascular Endothelial Growth Factor Inhibitor, Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery	Unknown status	NCT01229202	Phase 4	Bevacizumab
39	Assessment of the Effect of Moxonidine and Diet on Cardiac, Renal and Endothelial Function in Young Subjects With Abdominal Obesity	Unknown status	NCT01180231	Phase 4	Moxonidine (Physiotens)
40	The Effect of Far Infrared (FIR) Therapy on Access Flow of Arteriovenous (AV) Fistula, Echocardiographic Parameters and Endothelial Function in Patients With End Stage Renal Disease	Unknown status	NCT01138254	Phase 4
41	A Randomized, Prospective, Parallel Design Study to Compare the Effectiveness of Sitagliptin Versus Glimepiride on Endothelial Dysfunction During an Oral Glucose Loading in Drug Naive Patients With Type 2 Diabetes.	Unknown status	NCT02301806	Phase 4	Sitagliptin;Glimepiride
42	Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis	Unknown status	NCT02132234	Phase 4	Etanercept;Adalimumab;Certolizumab;Infliximab
43	The Effect of Single Dose of Atorvastatin on Change of Circulating Endothelial Microparticles	Unknown status	NCT02023892	Phase 4	atorvastatin;placebo
44	Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes	Unknown status	NCT01978405	Phase 4	Alpha lipoic acid
45	Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System	Unknown status	NCT00446810	Phase 4	Benfotiamine;Placebo
46	Effects of Continuous Positive Airway Pressure (CPAP) and Nebivolol Treatment on Arterial Blood Pressure and Endothelial Function in Hypertensive OSA Patients.	Unknown status	NCT01771406	Phase 4	Nebivolol
47	A Randomised, Placebo Controlled, Double Blind, Cross-over, Single Center Clinical Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease	Unknown status	NCT01768585	Phase 4	Ivabradine;Placebo
48	Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression, Severity, Symptoms and Left Ventricular Function Assessed by 2D Strain Echocardiography	Unknown status	NCT02060071	Phase 4
49	Endothelial Dysfunction in Systemic Lupus Erythematosus: Its Contribution to Abnormalities in Coronary Perfusion.	Unknown status	NCT00188188	Phase 4	quinipril
50	Phase 4 Study of Intravitreal Aflibercept Injection for Recalcitrant Central Retinal Vein Occlusion Associated Macular Edema Despite Prior Anti-Vascular Endothelial Growth Factor (VEGF) Therapy. (ARChiMEDES)	Unknown status	NCT01857544	Phase 4	Aflibercept

Search NIH Clinical Center for Endotheliitis

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Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

⁴⁰

Endothelial, Eye, Liver, Bone, Ovary, Bone Marrow, Smooth Muscle

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Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 338)

#	Title	Authors	PMID	Year
1	Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19. ⁶¹	Kirschenbaum D...Frontzek K	33249605	2021
2	COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies. ⁶¹	Calabretta E...Richardson P	33538335	2021
3	Rare presentation of sequential epithelial microsporidiosis and endotheliitis. ⁶¹	Chandran K...Murthy SI	33795265	2021
4	Biology of the Heparanase-Heparan Sulfate Axis and Its Role in Disease Pathogenesis. ⁶¹	Vlodavsky I...Ilan N	33794549	2021
5	Pathogenesis-directed therapy of 2019 novel coronavirus disease. ⁶¹	Stratton CW...Lu H	33073355	2021
6	Complement cascade in severe forms of COVID-19: recent advances in therapy. ⁶¹	Benmansour NC...Vivier E	33738806	2021
7	COVID-19 encephalopathy: clinical and neurobiological features. ⁶¹	Uginet M...Allali G	33782993	2021
8	Reply For: "Re: Endotheliitis in COVID-19-Positive Patients After Extremity Amputation for Acute Thrombotic Events". ⁶¹	Ilonzo N...Ting W	33684512	2021
9	Cerebrovascular Complications and Vessel Wall Imaging in COVID-19 Encephalopathy-A Pilot Study. ⁶¹	Uginet M...Lovblad KO	33770199	2021
10	Role of lupus anticoagulant and von Willebrand factor in chronic reactive endotheliitis in COVID-19. ⁶¹	Lopez Reboiro ML...Lopez Castro J	33737115	2021
11	Covid-19 and oral diseases: Crosstalk, synergy or association? ⁶¹	Brandini DA...Naqvi AR	33646645	2021
12	Proposal of a new nomenclature for the underlying pathogenetic mechanism of severe Coronavirus Disease-19: "Inflammatory Thrombosis with Immune Endotheliitis-ITIE". ⁶¹	Bilgin E...Ertenli AI	33388970	2021
13	COVID-19 and the clinical course of rheumatic manifestations. ⁶¹	Ahmed S...Gasparyan AY	33733315	2021
14	Case Report: Ischemic Enterocolitis Associated with Coronavirus Disease 2019: Two Case Reports and a Review of the Literature. ⁶¹	Kinjo T...Fujita J	33735103	2021
15	Herpes Simplex Virus Keratitis in a University Tertiary Referral Centre - Clinical Features and Surgical Approaches. ⁶¹	Alfaro Rangel R...Seitz B	33607690	2021
16	COVID-19 associated stroke and cerebral endotheliitis. ⁶¹	Stancu P...Lovblad KO	33549612	2021
17	Obesity, Nutrients and the Immune System in the Era of COVID-19. ⁶¹	De Bandt JP...Monin C	33668493	2021
18	Cytomegalovirus endotheliitis with recurrent anterior uveitis and secondary glaucoma misdiagnosed as HLA-B27 uveitis. ⁶¹	Tendolkar S...Senthil S	33608341	2021
19	MR-proADM as marker of endotheliitis predicts COVID-19 severity. ⁶¹	Garcia de Guadiana-Romualdo L...Andaluz-Ojeda D	33569769	2021
20	Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. ⁶¹	Lima-Morales R...Salmeron J	33578014	2021
21	Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin. ⁶¹	Qian Y...Fu M	33594363	2021
22	SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation. ⁶¹	Ostergaard L	33523608	2021
23	Presumed herpes simplex virus endotheliitis following ultra-thin Descemet's stripping automated endothelial keratoplasty. ⁶¹	Sharma A...Sharma R	33463607	2021
24	Coronavirus disease-19: The multi-level, multi-faceted vasculopathy. ⁶¹	Quinaglia T...Sposito AC	33706082	2021
25	Sudden cardiogenic shock mimicking fulminant myocarditis in a surviving teenager affected by severe acute respiratory syndrome coronavirus 2 infection. ⁶¹	Garau G...Hoffer E	33190387	2021
26	Findings of Hepatic Severe Acute Respiratory Syndrome Coronavirus-2 Infection. ⁶¹	Fiel MI...Schiano T	32992052	2021
27	Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis. ⁶¹	Satturwar S...Pantanowitz L	33481385	2021
28	Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients. ⁶¹	Leleu I...Errera MH	31642720	2021
29	Targeting the Vascular Endothelium in the Treatment of COVID-19. ⁶¹	Suvorava T...Kaesemeyer W	33079828	2021
30	SARS-CoV-2 leads to a small vessel endotheliitis in the heart. ⁶¹	Maccio U...Varga Z	33422990	2021
31	Discordant anti-SARS-CoV-2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. ⁶¹	Ko CJ...Damsky W	32895985	2021
32	Hyperacute multi-organ thromboembolic storm in COVID-19: a case report. ⁶¹	Chibane S...Lanthier S	32506364	2021
33	Management of cytomegalovirus corneal endotheliitis. ⁶¹	Wong AHY...Wan KH	33441165	2021
34	[Clinical and anatomical features of SARS-COV-2 with acute hemorrhagic necrotizing encephalopathy]. ⁶¹	Ermilov VV...Filatov VE	33512126	2021
35	Severe Cytomegalovirus anterior uveitis and corneal endotheliitis after use of topical tacrolimus. ⁶¹	Tsubota Y...Mayama C	33747827	2021
36	Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality. ⁶¹	Philippe A...Smadja DM	33449299	2021
37	Transbronchial biopsies' histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure. ⁶¹	Klein F...Caneva J	33411031	2021
38	Presentations and mechanisms of CNS disorders related to COVID-19. ⁶¹	Bodro M...Sanchez-Valle R	33310765	2021
39	Role of Tissue Factor in the Pathogenesis of COVID-19 and the Possible Ways to Inhibit It. ⁶¹	Canas CA...Bonilla-Abadia F	33784877	2021
40	Systemic arterio-venous thrombosis in COVID-19: A pictorial review. ⁶¹	Shankar A...Kalyanasundaram S	33574991	2021
41	Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies. ⁶¹	Ikezoe T	32902759	2021
42	Corneal Neurotization for Postherpetic Neurotrophic Keratopathy: Initial Experience and Clinical Outcomes. ⁶¹	Kim JS...Leyngold IM	32332687	2021
43	Endotheliitis in Coronavirus Disease 2019-Positive Patients After Extremity Amputation for Acute Thrombotic Events. ⁶¹	Ilonzo N...Ting W	33387621	2020
44	Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation. ⁶¹	Amigues I...Konig M	33146561	2020
45	[COVID-19 and venous thromboembolism]. ⁶¹	Trimaille A...Bonnet G	33081917	2020
46	The vascular side of COVID-19 disease. Position paper of the International Union of Angiology. ⁶¹	Costanzo L...Mansilha A	32892615	2020
47	Post-COVID-19 Syndrome (PC19S): Chronic Reactive Endotheliitis and Disseminated Vascular Disease. ⁶¹	Lopez Castro J	33496258	2020
48	The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review. ⁶¹	Bhattacharyya R...Lee JH	32844302	2020
49	Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses. ⁶¹	Nascimento Conde J...Mackow ER	33310781	2020
50	Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis. ⁶¹	Cardinale V...Alvaro D	33023827	2020

Sources

Genes for Endotheliitis

Genes related to Endotheliitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	6.54	GeneCards inferred via : Publications (show sections)
2	CXCL11	C-X-C Motif Chemokine Ligand 11	Protein Coding	6.54	GeneCards inferred via : Publications (show sections)
3	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	6.54	GeneCards inferred via : Publications (show sections)

Sources

Variations for Endotheliitis

Sources

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Sources

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.03	CXCL9 CXCL11 CXCL10
2	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	12.95	CXCL9 CXCL11 CXCL10
3	Integrin Pathway ⁶³ Show member pathways FAK1 Signaling ⁶³ GnRH Signaling ⁶³ Inhibition of Angiogenesis by TSP1 ⁶³ Transendothelial Migration of Leukocytes ⁶³ UPA-UPAR Pathway ⁶³	12.79	CXCL9 CXCL11 CXCL10
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	12.78	CXCL9 CXCL11 CXCL10
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.65	CXCL9 CXCL11 CXCL10
6	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Lipid and atherosclerosis ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.54	CXCL9 CXCL11 CXCL10
7	CCR5 Pathway in Macrophages ⁶³ Show member pathways Androgen Signaling ⁶³ Chemokine Signaling ⁶³ Chemokine signaling pathway ³⁶	12.26	CXCL9 CXCL11 CXCL10
8	Bacterial infections in CF airways ²³ Show member pathways IL-1 beta-dependent CFTR expression ²³ Immune response Bacterial infections in normal airways ²³ Immune response TLR signaling pathways ²³	11.65	CXCL11 CXCL10
9	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	11.47	CXCL9 CXCL11 CXCL10
10	Type II interferon signaling (IFNG) ¹	10.72	CXCL9 CXCL10
11	G-protein signaling_Rap2B regulation pathway ²³	10.34	CXCL9 CXCL11 CXCL10
12	CXCR3-mediated signaling events ¹	10.33	CXCL9 CXCL11 CXCL10

Sources

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.96	CXCL9 CXCL10
2	extracellular space	GO:0005615	8.8	CXCL9 CXCL11 CXCL10

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	9.74	CXCL9 CXCL11 CXCL10
2	G protein-coupled receptor signaling pathway	GO:0007186	9.72	CXCL9 CXCL11 CXCL10
3	immune response	GO:0006955	9.7	CXCL9 CXCL11 CXCL10
4	inflammatory response	GO:0006954	9.69	CXCL9 CXCL11 CXCL10
5	cell-cell signaling	GO:0007267	9.67	CXCL9 CXCL11 CXCL10
6	regulation of cell proliferation	GO:0042127	9.63	CXCL9 CXCL11 CXCL10
7	cellular response to lipopolysaccharide	GO:0071222	9.61	CXCL9 CXCL11 CXCL10
8	chemotaxis	GO:0006935	9.58	CXCL9 CXCL11 CXCL10
9	defense response to virus	GO:0051607	9.56	CXCL9 CXCL10
10	response to bacterium	GO:0009617	9.54	CXCL9 CXCL10
11	defense response	GO:0006952	9.54	CXCL9 CXCL11 CXCL10
12	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.5	CXCL9 CXCL11 CXCL10
13	T cell chemotaxis	GO:0010818	9.48	CXCL11 CXCL10
14	neutrophil chemotaxis	GO:0030593	9.43	CXCL9 CXCL11 CXCL10
15	chemokine-mediated signaling pathway	GO:0070098	9.33	CXCL9 CXCL11 CXCL10
16	antimicrobial humoral immune response mediated by antimicrobial peptide	GO:0061844	9.13	CXCL9 CXCL11 CXCL10
17	positive regulation of release of sequestered calcium ion into cytosol	GO:0051281	8.8	CXCL9 CXCL11 CXCL10

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.43	CXCL9 CXCL11 CXCL10
2	chemokine activity	GO:0008009	9.33	CXCL9 CXCL11 CXCL10
3	heparin binding	GO:0008201	9.32	CXCL11 CXCL10
4	CXCR chemokine receptor binding	GO:0045236	9.13	CXCL9 CXCL11 CXCL10
5	CXCR3 chemokine receptor binding	GO:0048248	8.8	CXCL9 CXCL11 CXCL10

Sources

Sources for Endotheliitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia