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MCID: END072
MIFTS: 40

Endotheliitis

Categories: Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Endotheliitis

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MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis 59

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA137602
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Summaries for Endotheliitis

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MalaCards based summary : Endotheliitis is related to carrion's disease and psoriasis. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Ganciclovir and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Endotheliitis is an immune response within endothelium in blood vessels, in which they become inflamed. ... more...

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Related Diseases for Endotheliitis

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Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1391)
# Related Disease Score Top Affiliating Genes
1 carrion's disease 31.2 CXCL10 CXCL9
2 psoriasis 29.8 CXCL10 CXCL9
3 encephalitis 29.6 CXCL10 CXCL9
4 multiple sclerosis 29.6 CXCL10 CXCL11 CXCL9
5 pulmonary fibrosis, idiopathic 29.5 CXCL10 CXCL9
6 alopecia areata 29.2 CXCL10 CXCL9
7 dermatitis, atopic 29.2 CXCL10 CXCL9
8 cryoglobulinemia 29.1 CXCL10 CXCL11
9 mycosis fungoides 28.8 CXCL10 CXCL11 CXCL9
10 tick-borne encephalitis 28.7 CXCL10 CXCL11
11 corneal endothelial dystrophy 12.6
12 fuchs' endothelial dystrophy 12.6
13 corneal dystrophy, fuchs endothelial, 1 12.6
14 corneal endothelial dystrophy type 2 12.5
15 corneal dystrophy, fuchs endothelial, 3 12.4
16 intravascular papillary endothelial hyperplasia 12.4
17 corneal dystrophy, fuchs endothelial, 4 12.4
18 corneal dystrophy, fuchs endothelial, 6 12.4
19 iridocorneal endothelial syndrome 12.4
20 corneal dystrophy, fuchs endothelial, 2 12.3
21 corneal dystrophy, fuchs endothelial, 8 12.3
22 corneal dystrophy, fuchs endothelial, 5 12.3
23 corneal dystrophy, endothelial, x-linked 12.3
24 congenital hereditary endothelial dystrophy type i 12.2
25 corneal dystrophy, fuchs endothelial, 7 12.1
26 corneal dystrophy, posterior polymorphous, 1 12.1
27 endothelial dystrophy, congenital hereditary, with nail hypoplasia 11.9
28 corneal dystrophy and perceptive deafness 11.9
29 edict syndrome 11.8
30 spotted fever 11.3
31 lymphangiosarcoma 11.3
32 pulmonary hypertension, primary, 1 11.3
33 hemangioma 11.3
34 bullous keratopathy 11.2
35 cerebral cavernous malformations 11.2
36 hemolytic-uremic syndrome 11.2
37 hepatic veno-occlusive disease 11.2
38 angioimmunoblastic t-cell lymphoma 11.2
39 essential iris atrophy 11.2
40 macular dystrophy, corneal 11.2
41 aneurysmal bone cysts 11.2
42 heme oxygenase 1 deficiency 11.2
43 epidemic typhus 11.2
44 susac syndrome 11.2
45 capillary malformations, congenital 11.2
46 hemangioma, capillary infantile 11.1
47 hepatic lipase deficiency 11.1
48 vascular hemostatic disease 11.1
49 kanzaki disease 11.0
50 corneal dystrophy, congenital stromal 11.0

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis
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Symptoms & Phenotypes for Endotheliitis

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GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.32 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 CXCL10 CXCL11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.32 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 CXCL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.32 CXCL11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CXCL11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.32 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 CXCL10
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Drugs & Therapeutics for Endotheliitis

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Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Difluprednate Approved Phase 4 23674-86-4 443936
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Acyclovir Approved Phase 4 59277-89-3 2022
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
10 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Not Applicable
11 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
12 Antiviral Agents Phase 4,Phase 2,Phase 3,Not Applicable
13 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
14 Ophthalmic Solutions Phase 4
15 Prednisolone acetate Phase 4
16 Methylprednisolone acetate Phase 4
17 valacyclovir Phase 4
18
Valganciclovir Approved, Investigational Phase 2, Phase 3 175865-60-8 64147

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
2 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
3 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
4 Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis Unknown status NCT01359995
5 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Not Applicable Ganciclovir

Search NIH Clinical Center for Endotheliitis

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Genetic Tests for Endotheliitis

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Anatomical Context for Endotheliitis

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MalaCards organs/tissues related to Endotheliitis:

41
Endothelial, Eye, Liver, Brain, Heart, Breast, Thyroid
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Publications for Endotheliitis

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Articles related to Endotheliitis:

(show top 50) (show all 95)
# Title Authors Year
1
Topical Ganciclovir for Prophylaxis of Cytomegalovirus Endotheliitis in Endothelial Keratoplasty. ( 30379718 )
2019
2
Descemet membrane endothelial keratoplasty for corneal decompensation caused by herpes simplex virus endotheliitis. ( 29502597 )
2018
3
Role of Dendritic Cells and Inflammatory Cells in Herpetic Endotheliitis: Analysis Using In Vivo Confocal Microscopy. ( 29543663 )
2018
4
The Effect of Topical Ganciclovir and Corticosteroid on Cytomegalovirus Corneal Endotheliitis in Korean Patients. ( 29953306 )
2018
5
Fungal corneal endotheliitis: a series of case reports. ( 29977824 )
2018
6
Incidence and Risk Factors of New Onset Endotheliitis After Cataract Surgery. ( 30372749 )
2018
7
Clinical Results and Utility of Herpesviruses Multiplex Polymerase Chain Reaction: Assessment of Aqueous Humor Samples From Patients With Corneal Endotheliitis and High Intraocular Pressure. ( 30234744 )
2018
8
Clinical Manifestations and Characteristics of In Vivo Confocal Microscopy in Varicella Zoster Virus-Related Corneal Endotheliitis. ( 30252558 )
2018
9
Cerebral adenovirus endotheliitis presenting as posterior reversible encephalopathy syndrome after allogeneic stem cell transplantation. ( 28692025 )
2017
10
CMV endotheliitis: a cause for recurrent failed corneal transplant. ( 29326863 )
2017
11
Sinusoidal endotheliitis as a histological parameter for diagnosing acute liver allograft rejection. ( 28223723 )
2017
12
Clinical features, diagnosis and treatment outcomes of cytomegalovirus endotheliitis in Hong Kong. ( 27306329 )
2016
13
Long-Term Topical Ganciclovir and Corticosteroids Preserve Corneal Endothelial Function in Cytomegalovirus Corneal Endotheliitis. ( 26967107 )
2016
14
Acute Bilateral Toxic Endotheliitis Following Alcohol Consumption. ( 27494457 )
2016
15
Activation of Cytomegalovirus corneal endotheliitis following laser in situ keratomileusis. ( 27899387 )
2016
16
Multiple parallel-line endotheliitis: case report and literature review of an emerging entity. ( 27316289 )
2016
17
The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis. ( 27142389 )
2016
18
Management of recurrent acute bilateral corneal endotheliitis monitored by serial corneal pachymetry. ( 28050086 )
2016
19
Differential Changes in Intraocular Pressure and Corneal Manifestations in Individuals With Viral Endotheliitis After Keratoplasty. ( 26967113 )
2016
20
Descemet Stripping Automated Endothelial Keratoplasty Outcomes in Patients With Cytomegalovirus Endotheliitis. ( 27661068 )
2016
21
Clinical Findings of Anterior Segment Spectral Domain Optical Coherence Tomography Images in Cytomegalovirus Corneal Endotheliitis. ( 27941387 )
2016
22
In Vivo Confocal Microscopy Use in Endotheliitis. ( 26540476 )
2015
23
Polymorphisms in cytomegalovirus genotype in immunocompetent patients with corneal endotheliitis or iridocyclitis. ( 25963863 )
2015
24
Rare Anterior Segment Retinoblastoma Masquerading as Corneal Endotheliitis. ( 25961779 )
2015
25
Herpes Simplex Virus Endotheliitis following Descemet's Membrane Endothelial Keratoplasty. ( 26425323 )
2015
26
In vivo imaging of coin-shaped lesions in cytomegalovirus corneal endotheliitis by anterior segment optical coherence tomography. ( 25285587 )
2014
27
A case of corneal endothelial dysfunction due to coxsackievirus A24 corneal endotheliitis after cataract surgery. ( 24608251 )
2014
28
Acute Idiopathic Endotheliitis Early After Corneal Cross-linking With Riboflavin and Ultraviolet-A. ( 24699560 )
2014
29
Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study. ( 25075122 )
2014
30
Review of clinical and basic approaches to corneal endotheliitis. ( 25170583 )
2014
31
Progressive cicatrizing endotheliitis associated with leucocytoclastic vasculitis and Crohn disease. ( 23514527 )
2013
32
A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR. ( 23252654 )
2013
33
Identification of cytomegalovirus and human herpesvirus-6 DNA in a patient with corneal endotheliitis. ( 23247975 )
2013
34
Concomitant herpes simplex virus and cytomegalovirus endotheliitis in immunocompetent patient. ( 23667217 )
2013
35
Mapping owl's eye cells of patients with cytomegalovirus corneal endotheliitis using in vivo laser confocal microscopy. ( 23124832 )
2013
36
Cytomegalovirus-related corneal endotheliitis: A review article. ( 23964187 )
2013
37
Infectious endotheliitis: a rare case of presumed mycotic origin. ( 23901253 )
2013
38
Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty. ( 23009154 )
2013
39
A case of CMV endotheliitis treated with intravitreal ganciclovir injection. ( 23543604 )
2013
40
Outcomes of corneal transplantation for irreversible corneal decompensation secondary to corneal endotheliitis in Asian eyes. ( 23622566 )
2013
41
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. ( 23957427 )
2013
42
Bilateral lineal endotheliitis: case report. ( 23828474 )
2013
43
Clinical significance of owl eye morphologic features by in vivo laser confocal microscopy in patients with cytomegalovirus corneal endotheliitis. ( 22030352 )
2012
44
Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with rift valley fever virus. ( 21601870 )
2012
45
Multiple parallel-line endotheliitis--a form of herpes simplex keratitis? ( 22179220 )
2012
46
Post-phacoemulsification cytomegalovirus corneal endotheliitis diagnosis and management. ( 22768376 )
2012
47
Immune ring formation associated with cytomegalovirus endotheliitis. ( 22813453 )
2012
48
Treatment outcome and risk factors for visual loss in Cytomegalovirus endotheliitis. ( 21892696 )
2012
49
Expression of CXCL9, -10, and -11 in the aqueous humor of patients with herpetic endotheliitis. ( 22367045 )
2012
50
Endothelial damage after cardiac arrest--"endotheliitis". ( 22429972 )
2012
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Variations for Endotheliitis

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Expression for Endotheliitis

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Search GEO for disease gene expression data for Endotheliitis.
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Pathways for Endotheliitis

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Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 64
Show member pathways
 13.06 CXCL10 CXCL11 CXCL9
2
Peptide ligand-binding receptors 66
Show member pathways
 12.98 CXCL10 CXCL11 CXCL9
3
Akt Signaling 64
Show member pathways
 12.85 CXCL10 CXCL11 CXCL9
4
Integrin Pathway 64
Show member pathways
 12.82 CXCL10 CXCL11 CXCL9
5
PAK Pathway 64
Show member pathways
 12.72 CXCL10 CXCL11 CXCL9
6
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.48 CXCL10 CXCL11 CXCL9
7
CCR5 Pathway in Macrophages 64
Show member pathways
 12.37 CXCL10 CXCL11 CXCL9
8
Bacterial infections in CF airways 22
Show member pathways
 11.71 CXCL10 CXCL11
9
G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins 22
Show member pathways
 11.68 CXCL10 CXCL11 CXCL9
10
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.4 CXCL10 CXCL11 CXCL9
11
Microglia Activation During Neuroinflammation: Microglia Polarization 65
10.98 CXCL10 CXCL11 CXCL9
12
Type II interferon signaling (IFNG) 1
10.89 CXCL10 CXCL9
13
G-protein signaling_RhoB regulation pathway 22
10.66 CXCL10 CXCL11 CXCL9
14
G-protein signaling_Rap2B regulation pathway 22
10.45 CXCL10 CXCL11 CXCL9
15
CXCR3-mediated signaling events 1
10.33 CXCL10 CXCL11 CXCL9
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GO Terms for Endotheliitis

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Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.16 CXCL10 CXCL9
2 extracellular space GO:0005615 9.13 CXCL10 CXCL11 CXCL9
3 intracellular GO:0005622 8.8 CXCL10 CXCL11 CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.77 CXCL10 CXCL11 CXCL9
2 G protein-coupled receptor signaling pathway GO:0007186 9.75 CXCL10 CXCL11 CXCL9
3 immune response GO:0006955 9.73 CXCL10 CXCL11 CXCL9
4 regulation of signaling receptor activity GO:0010469 9.72 CXCL10 CXCL11 CXCL9
5 inflammatory response GO:0006954 9.71 CXCL10 CXCL11 CXCL9
6 cell-cell signaling GO:0007267 9.7 CXCL10 CXCL11 CXCL9
7 regulation of cell proliferation GO:0042127 9.67 CXCL10 CXCL11 CXCL9
8 cellular response to lipopolysaccharide GO:0071222 9.65 CXCL10 CXCL11 CXCL9
9 chemotaxis GO:0006935 9.63 CXCL10 CXCL11 CXCL9
10 defense response GO:0006952 9.61 CXCL10 CXCL11 CXCL9
11 defense response to virus GO:0051607 9.58 CXCL10 CXCL9
12 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.58 CXCL10 CXCL11 CXCL9
13 response to bacterium GO:0009617 9.57 CXCL10 CXCL9
14 neutrophil chemotaxis GO:0030593 9.54 CXCL10 CXCL11 CXCL9
15 T cell chemotaxis GO:0010818 9.51 CXCL10 CXCL11
16 chemokine-mediated signaling pathway GO:0070098 9.5 CXCL10 CXCL11 CXCL9
17 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.43 CXCL10 CXCL11 CXCL9
18 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.33 CXCL10 CXCL11 CXCL9
19 leukocyte chemotaxis GO:0030595 9.13 CXCL10 CXCL11 CXCL9
20 positive regulation of cAMP-mediated signaling GO:0043950 8.8 CXCL10 CXCL11 CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL10 CXCL9
2 heparin binding GO:0008201 9.16 CXCL10 CXCL11
3 chemokine activity GO:0008009 9.13 CXCL10 CXCL11 CXCL9
4 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL10 CXCL11 CXCL9
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Sources for Endotheliitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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