MCID: END072
MIFTS: 36

Endotheliitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

Orphanet 58 ORPHA137602

Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to severe acute respiratory syndrome and pulmonary fibrosis, idiopathic. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Abacavir and Curcumin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Endotheliitis is an immune response within the endothelium in blood vessels, in which they become... more...

Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 severe acute respiratory syndrome 30.0 CXCL9 CXCL10
2 pulmonary fibrosis, idiopathic 29.0 CXCL9 CXCL10
3 corneal edema 10.6
4 herpes simplex 10.5
5 uveitis 10.4
6 iridocyclitis 10.4
7 chickenpox 10.4
8 keratitis, hereditary 10.3
9 bullous keratopathy 10.3
10 keratopathy 10.3
11 covid-19 10.2
12 cataract 10.1
13 ifap syndrome 2 10.1
14 neuroretinitis 10.1
15 retinitis 10.1
16 ocular hypertension 10.1
17 thrombosis 10.0
18 mumps 10.0
19 vascular disease 10.0
20 mansonelliasis 9.9 CXCL9 CXCL10
21 acrodermatitis 9.9 CXCL9 CXCL10
22 spotted fever 9.9 CXCL9 CXCL10
23 stroke, ischemic 9.9
24 human cytomegalovirus infection 9.9
25 corneal disease 9.9
26 parotitis 9.9
27 iritis 9.9
28 viral hepatitis 9.9
29 vasculitis 9.9
30 acanthamoeba keratitis 9.9
31 encephalopathy 9.9
32 paracoccidioidomycosis 9.9 CXCL9 CXCL10
33 viral encephalitis 9.9 CXCL9 CXCL10
34 encephalitis 9.9 CXCL9 CXCL10
35 proliferative glomerulonephritis 9.9 CXCL9 CXCL10
36 alopecia areata 9.9 CXCL9 CXCL10
37 trypanosomiasis 9.9 CXCL9 CXCL10
38 sarcoidosis 1 9.8 CXCL9 CXCL10
39 dermatitis 9.8 CXCL9 CXCL11
40 interstitial lung disease 9.8 CXCL9 CXCL10
41 polycystic echinococcosis 9.8 CXCL11 CXCL10
42 mycobacterium tuberculosis 1 9.8 CXCL9 CXCL10
43 cerebral amyloid angiopathy, cst3-related 9.8
44 autoimmune disease 9.8
45 facial spasm 9.8
46 hemifacial spasm, familial 9.8
47 retinoblastoma 9.8
48 sneddon syndrome 9.8
49 corneal endothelial dystrophy 9.8
50 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis

Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.4 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.4 CXCL11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.4 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.4 CXCL11
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.4 CXCL10
6 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.4 CXCL10
7 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.4 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.4 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.4 CXCL10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 CXCL11
11 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.4 CXCL10
12 Increased shRNA abundance (Z-score > 2) GR00366-A-94 9.4 CXCL10

Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 670)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
2
Curcumin Approved, Experimental, Investigational Phase 4 458-37-7 969516
3
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
4
Insulin glulisine Approved Phase 4 207748-29-6
5
Mineral oil Approved, Vet_approved Phase 4 8042-47-5
6
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
7
Certolizumab pegol Approved Phase 4 428863-50-7
8
Chromium Approved Phase 4 7440-47-3 27668
9
Cobalt Approved, Experimental Phase 4 7440-48-4 104729
10
Adenosine Approved, Investigational Phase 4 58-61-7 60961
11
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
12
Bevacizumab Approved, Investigational Phase 4 216974-75-3
13
Nebivolol Approved, Investigational Phase 4 152520-56-4, 118457-14-0, 99200-09-6 71301
14
Infliximab Approved Phase 4 170277-31-3
15
Paclitaxel Approved, Vet_approved Phase 4 33069-62-4 36314
16
Protein C Approved Phase 4
17
tannic acid Approved Phase 4 1401-55-4
18
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
19
Tocopherol Approved, Investigational Phase 4 1406-66-2
20
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
21
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
22
Lactitol Approved, Investigational Phase 4 585-86-4 157355
23
Ezetimibe Approved Phase 4 163222-33-1 150311
24
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
25
Telmisartan Approved, Investigational Phase 4 144701-48-4 65999
26
Febuxostat Approved Phase 4 144060-53-7 134018
27
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
28
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
29
Ketoconazole Approved, Investigational Phase 4 65277-42-1 47576
30
Allopurinol Approved Phase 4 315-30-0 2094
31
Bosentan Approved, Investigational Phase 4 147536-97-8 104865
32
Linagliptin Approved Phase 4 668270-12-0 10096344
33
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
34
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
35
Glyburide Approved Phase 4 10238-21-8 3488
36
Insulin glargine Approved Phase 4 160337-95-1
37
Insulin detemir Approved Phase 4 169148-63-4 5311023
38
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
39
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
40
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
41
Fenofibrate Approved Phase 4 49562-28-9 3339
42
Acetaminophen Approved Phase 4 103-90-2 1983
43
Caffeine Approved Phase 4 58-08-2 2519
44
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
45
Pitavastatin Approved Phase 4 147511-69-1, 147526-32-7 6366718 5282452
46
Epoprostenol Approved Phase 4 61849-14-7, 35121-78-9 5280427 5282411
47
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
48
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
49
Drospirenone Approved Phase 4 67392-87-4 68873
50
Atenolol Approved Phase 4 29122-68-7 2249

Interventional clinical trials:

(show top 50) (show all 1657)
# Name Status NCT ID Phase Drugs
1 To Compare the Efficacy of Monotherapy With Anti-Vascular Endothelial Growth Factor (Ranibizumab or Bevacizumab) Versus Combination Therapy With Anti-Vascular Endothelial Growth Factor and End-point-management Grid Laser Photocoagulation for Diabetic Macular Edema Unknown status NCT02462304 Phase 4 ranibizumab;Bevacizumab
2 Cilostazol Enhances the Number and Functions of Circulating Endothelial Progenitor Cells and Endothelial Function Mediated Through Modification of Vasculogenesis and Angiogenesis Factors in Patients With Stable Coronary Artery Disease Unknown status NCT02174939 Phase 4 Cilostazol;Dummy Placebo
3 Evaluate the Effect of Exenatide Treatment on Coronary Artery Endothelial Function Unknown status NCT02584075 Phase 4 Byetta (Exenatide);Glucophage ( Metformin Hydrochloride)
4 Effect of Gemigliptin or Acarbose on Endothelial Function in Type 2 DM Patients (GetUp Trial) Unknown status NCT02500329 Phase 4 Gemigliptin;Acarbose
5 Maraviroc Abacavir STudy - Effect on Endothelial Recovery Unknown status NCT01389063 Phase 4 Maraviroc
6 A Randomized, Observer-masked, Clinical Trial Comparing the Neusidl Corneal Inserter Corneal Transplant Technique to the Standard Forceps Insertion Technique for Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT01357122 Phase 4
7 Effect of Coreg CR on BP, Endothelial Function, Exhaled Nitric Oxide, and Nitric Oxide Production and Oxidation Unknown status NCT00732511 Phase 4 carvedilol;metoprolol extended release
8 Effect of Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor on Systemic and Renal Endothelial Function in Patients With Type 2 Diabetes Mellitus Without History of Coronary Artery Disease (SOCCER Trial) Unknown status NCT02501616 Phase 4 Metformin;Dapagliflozin
9 A Prospective Randomized Double Blind Study to Evaluate the Effect of Ticagrelor on Endothelial Function Unknown status NCT02261922 Phase 4 ticagrelor;prasugrel
10 Comparison of the Effects of Ticagrelor Versus Clopidogrel on Endothelial Dysfunction and Vascular Inflammation in Patients With Prior Non-ST-segment Acute Coronary Syndrome Unknown status NCT02379676 Phase 4 Ticagrelor;Clopidogrel
11 Personalized Medicine in HCV Chronic Infection. Endothelial Dysfunction and Subclinical Atheromatosis in Patients With HCV Infection. Characterization and Potential Reversibility With Direct Antiviral Agents. Unknown status NCT02802280 Phase 4
12 Predictors of Treatment Response to Aflibercept and Aqueous Cytokine Levels in Patients With Persistent Diabetic Macular Edema Following Treatment With Ranibizumab: An Interventional Prospective Study Unknown status NCT02651168 Phase 4
13 Randomized Placebo-controlled Crossover Trial of Endothelial Function Improvement in Subjects With History of Premature Coronary Artery Disease Unknown status NCT00917527 Phase 4 Atorvastatin
14 Effect of aSpirin Versus CilOstazol for Inhibition of Antiplatelet aggRegaTion in Type 2 DM Patients Unknown status NCT02933788 Phase 4 Cilostazol;Acetylsalicylic acid
15 Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis Unknown status NCT01752335 Phase 4
16 Telmisartan vs Ramipril for Reduction of Inflammation and Recruitment of Endothelial Progenitor Cells After Acute Coronary Syndrome Unknown status NCT00702936 Phase 4 TELMISARTAN;RAMIPRIL
17 Type 2 Diabetes Mellitus: Role of Inflammation and Innate Immunity in The Pathogenesis of Endothelial Dysfunction and Atherosclerosis Unknown status NCT01250340 Phase 4 Aspirin;Placebo
18 A TElmisartan and AMlodipine STudy to Assess the Cardiovascular PROTECTive Effects as Measured by Endothelial Dysfunction in Hypertensive at Risk Patients Beyond Blood Pressure Unknown status NCT01180205 Phase 4 Telmisartan;Amlodipine;Olmesartan medoxomil;Hydrochlorothiazide
19 Phase IV, Randomized, Open Label, Crossover, Intervention Trial to Investigate the Effect of the Switch of Lopinavir/Ritonavir to Raltegravir on Endothelial Function, Chronic Inflammation, Immune Activation and HIV Replication <50 Copies/ml Unknown status NCT01453933 Phase 4 raltegravir
20 Effects of Sevoflurane in Subanesthetic Concentrations on the Forearm Perfusion, Leukocyte/Thrombocyte Activation, and Endothelial Function After Tourniquet-Induced Ischemia/Reperfusion Injury in the Forearm of Volunteers Unknown status NCT00526695 Phase 4 Sevoflurane (Preconditioning)
21 A Prospective, Randomized, Two Period, With an Intermediate Wash Out Period, Cross-over Study to Compare the Effects of Either Combined Therapy With Ramipril and Clopidogrel or Ramipril Monotherapy on Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Patients With Type 2 Diabetes and Diabetic Nephropathy Unknown status NCT01743014 Phase 4 Ramipril;Clopidogrel
22 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effect of Roflumilast on Endothelial Function in Patients With Chronic Obstructive Pulmonary Disease Unknown status NCT01595750 Phase 4 Roflumilast 500;Placebo
23 Study Effects of Ginkgo Biloba Extract on Endothelial Cell Function and Genetic Effects on the Response to Ginkgo Biloba Extract in Diabetic Patients With Stable Coronary Artery Disease Unknown status NCT01038050 Phase 4 Ginkgo Biloba Extract (GBE)
24 Changes in Central Aortic Pressure, Endothelial Function and Biomarkers in African Americans With Cardiometabolic Syndrome: Comparison of Amlodipine/Olmesartan Versus Hydrochlorothiazide/Losartan Unknown status NCT01271374 Phase 4 amlodipine and olmesartan;losartan and HCTZ
25 Investigation of the Atherogenic Effects of Uric Acid-modified in Endothelial Dysfunction and the the Preventional Mechanism by Anthocyanidines Unknown status NCT02797028 Phase 4 Allopurinol
26 Effects of On-Line Hemodiafiltration(HDF) on Endothelial Dysfunction in Chronic Hemodialysis Patients Unknown status NCT00532597 Phase 4
27 Prospective Influence of Bedtime Insulin Glargine on Mobilization and Function of Endothelial Progenitor Cells in Patients With Type 2 Diabetes: a Partially Double-Blind, Randomized, Three-Arm Unicenter Study Unknown status NCT00523393 Phase 4 Insulin Glargin;Human Insulin
28 The Comparison of Endothelial Cell Count in Pterygium Surgery Relating to the Timing of MMC Application. Unknown status NCT02641132 Phase 4 Mitomycin C 0.02%
29 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Gene Expression and Serum Levels of Some Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
30 Human Insulin Analogs: Evaluation of Inflammatory mRNA Expression of Macrophages and Endothelial Function of Short-acting Insulin - HERMES Pilot Study Unknown status NCT01417897 Phase 4 Insulin glulisine;Insulin aspart;Regular human insulin
31 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES" Unknown status NCT01168700 Phase 4 aged garlic extract;Placebo
32 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
33 Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart Failure: Effects of Endothelial Progenitor Cells and a Direct Renin Inhibitor Unknown status NCT01156207 Phase 4 Aliskiren
34 Prospective, Randomized, Double - Blind Placebo Controlled Trial of Simvastatin and Resveratrol Therapy on Clinical, Endocrinological, Biochemical and Endothelial Dysfunction Parameters in Women With Polycystic Ovary Syndrome. Unknown status NCT02766803 Phase 4 Simvastatin and micronized trans-resveratrol
35 Early Re-Endothelialization Might Not be the Unique Solution to Prevent Restenosis. The EREMUS Study Unknown status NCT00870038 Phase 4
36 NSAIDs vs. Coxibs in the Presence of Aspirin: Effects on Platelet Function, Endothelial Function, and Biomarkers of Inflammation in Subjects With Rheumatoid Arthritis and Increased Cardiovascular Risk or Cardiovascular Disease Unknown status NCT03699293 Phase 4 celecoxib 200mg capsule;naproxen sodium 550mg tablet;Aspirin 81mg tablet
37 The Difference of Circulating Endothelial-derived and Platelet-derived Microparticles in Patients With Psoriasis Successfully Treated With Stelara(Ustekinumab) Unknown status NCT02693470 Phase 4 Ustekinumab
38 Use of Vascular Endothelial Growth Factor Inhibitor, Bevacizumab to Modulate the Outcomes of Trabeculectomy Surgery Unknown status NCT01229202 Phase 4 Bevacizumab
39 Assessment of the Effect of Moxonidine and Diet on Cardiac, Renal and Endothelial Function in Young Subjects With Abdominal Obesity Unknown status NCT01180231 Phase 4 Moxonidine (Physiotens)
40 The Effect of Far Infrared (FIR) Therapy on Access Flow of Arteriovenous (AV) Fistula, Echocardiographic Parameters and Endothelial Function in Patients With End Stage Renal Disease Unknown status NCT01138254 Phase 4
41 A Randomized, Prospective, Parallel Design Study to Compare the Effectiveness of Sitagliptin Versus Glimepiride on Endothelial Dysfunction During an Oral Glucose Loading in Drug Naive Patients With Type 2 Diabetes. Unknown status NCT02301806 Phase 4 Sitagliptin;Glimepiride
42 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
43 The Effect of Single Dose of Atorvastatin on Change of Circulating Endothelial Microparticles Unknown status NCT02023892 Phase 4 atorvastatin;placebo
44 Short-Term Alpha Lipoic Acid Therapy for Prevention of Contrast-induced Acute Kidney Injury and Endothelial Dysfunction in Type 2 Diabetes Unknown status NCT01978405 Phase 4 Alpha lipoic acid
45 Effects of a Chronical Treatment With Benfotiamine in People With Type 2 Diabetes Mellitus on Pre- and Postprandial Endothelial Function, as Well as on the Function of the Autonomic Nervous System Unknown status NCT00446810 Phase 4 Benfotiamine;Placebo
46 Effects of Continuous Positive Airway Pressure (CPAP) and Nebivolol Treatment on Arterial Blood Pressure and Endothelial Function in Hypertensive OSA Patients. Unknown status NCT01771406 Phase 4 Nebivolol
47 A Randomised, Placebo Controlled, Double Blind, Cross-over, Single Center Clinical Study to Investigate the Effect of Heart Rate Reduction With Ivabradine on Vascular Elastic Properties and Endothelial Function in Patients With Stable Coronary Heart Disease Unknown status NCT01768585 Phase 4 Ivabradine;Placebo
48 Endothelial Progenitors in Aortic Stenosis: Association With Aortic Stenosis Progression, Severity, Symptoms and Left Ventricular Function Assessed by 2D Strain Echocardiography Unknown status NCT02060071 Phase 4
49 Endothelial Dysfunction in Systemic Lupus Erythematosus: Its Contribution to Abnormalities in Coronary Perfusion. Unknown status NCT00188188 Phase 4 quinipril
50 Phase 4 Study of Intravitreal Aflibercept Injection for Recalcitrant Central Retinal Vein Occlusion Associated Macular Edema Despite Prior Anti-Vascular Endothelial Growth Factor (VEGF) Therapy. (ARChiMEDES) Unknown status NCT01857544 Phase 4 Aflibercept

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

40
Endothelial, Eye, Liver, Bone, Ovary, Bone Marrow, Smooth Muscle

Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 338)
# Title Authors PMID Year
1
Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19. 61
33249605 2021
2
COVID-19-induced endotheliitis: emerging evidence and possible therapeutic strategies. 61
33538335 2021
3
Rare presentation of sequential epithelial microsporidiosis and endotheliitis. 61
33795265 2021
4
Biology of the Heparanase-Heparan Sulfate Axis and Its Role in Disease Pathogenesis. 61
33794549 2021
5
Pathogenesis-directed therapy of 2019 novel coronavirus disease. 61
33073355 2021
6
Complement cascade in severe forms of COVID-19: recent advances in therapy. 61
33738806 2021
7
COVID-19 encephalopathy: clinical and neurobiological features. 61
33782993 2021
8
Reply For: "Re: Endotheliitis in COVID-19-Positive Patients After Extremity Amputation for Acute Thrombotic Events". 61
33684512 2021
9
Cerebrovascular Complications and Vessel Wall Imaging in COVID-19 Encephalopathy-A Pilot Study. 61
33770199 2021
10
Role of lupus anticoagulant and von Willebrand factor in chronic reactive endotheliitis in COVID-19. 61
33737115 2021
11
Covid-19 and oral diseases: Crosstalk, synergy or association? 61
33646645 2021
12
Proposal of a new nomenclature for the underlying pathogenetic mechanism of severe Coronavirus Disease-19: "Inflammatory Thrombosis with Immune Endotheliitis-ITIE". 61
33388970 2021
13
COVID-19 and the clinical course of rheumatic manifestations. 61
33733315 2021
14
Case Report: Ischemic Enterocolitis Associated with Coronavirus Disease 2019: Two Case Reports and a Review of the Literature. 61
33735103 2021
15
Herpes Simplex Virus Keratitis in a University Tertiary Referral Centre - Clinical Features and Surgical Approaches. 61
33607690 2021
16
COVID-19 associated stroke and cerebral endotheliitis. 61
33549612 2021
17
Obesity, Nutrients and the Immune System in the Era of COVID-19. 61
33668493 2021
18
Cytomegalovirus endotheliitis with recurrent anterior uveitis and secondary glaucoma misdiagnosed as HLA-B27 uveitis. 61
33608341 2021
19
MR-proADM as marker of endotheliitis predicts COVID-19 severity. 61
33569769 2021
20
Effectiveness of a multidrug therapy consisting of Ivermectin, Azithromycin, Montelukast, and Acetylsalicylic acid to prevent hospitalization and death among ambulatory COVID-19 cases in Tlaxcala, Mexico. 61
33578014 2021
21
Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin. 61
33594363 2021
22
SARS CoV-2 related microvascular damage and symptoms during and after COVID-19: Consequences of capillary transit-time changes, tissue hypoxia and inflammation. 61
33523608 2021
23
Presumed herpes simplex virus endotheliitis following ultra-thin Descemet's stripping automated endothelial keratoplasty. 61
33463607 2021
24
Coronavirus disease-19: The multi-level, multi-faceted vasculopathy. 61
33706082 2021
25
Sudden cardiogenic shock mimicking fulminant myocarditis in a surviving teenager affected by severe acute respiratory syndrome coronavirus 2 infection. 61
33190387 2021
26
Findings of Hepatic Severe Acute Respiratory Syndrome Coronavirus-2 Infection. 61
32992052 2021
27
Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis. 61
33481385 2021
28
Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients. 61
31642720 2021
29
Targeting the Vascular Endothelium in the Treatment of COVID-19. 61
33079828 2021
30
SARS-CoV-2 leads to a small vessel endotheliitis in the heart. 61
33422990 2021
31
Discordant anti-SARS-CoV-2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. 61
32895985 2021
32
Hyperacute multi-organ thromboembolic storm in COVID-19: a case report. 61
32506364 2021
33
Management of cytomegalovirus corneal endotheliitis. 61
33441165 2021
34
[Clinical and anatomical features of SARS-COV-2 with acute hemorrhagic necrotizing encephalopathy]. 61
33512126 2021
35
Severe Cytomegalovirus anterior uveitis and corneal endotheliitis after use of topical tacrolimus. 61
33747827 2021
36
Circulating Von Willebrand factor and high molecular weight multimers as markers of endothelial injury predict COVID-19 in-hospital mortality. 61
33449299 2021
37
Transbronchial biopsies' histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure. 61
33411031 2021
38
Presentations and mechanisms of CNS disorders related to COVID-19. 61
33310765 2021
39
Role of Tissue Factor in the Pathogenesis of COVID-19 and the Possible Ways to Inhibit It. 61
33784877 2021
40
Systemic arterio-venous thrombosis in COVID-19: A pictorial review. 61
33574991 2021
41
Advances in the diagnosis and treatment of disseminated intravascular coagulation in haematological malignancies. 61
32902759 2021
42
Corneal Neurotization for Postherpetic Neurotrophic Keratopathy: Initial Experience and Clinical Outcomes. 61
32332687 2021
43
Endotheliitis in Coronavirus Disease 2019-Positive Patients After Extremity Amputation for Acute Thrombotic Events. 61
33387621 2020
44
Coronavirus disease 2019: investigational therapies in the prevention and treatment of hyperinflammation. 61
33146561 2020
45
[COVID-19 and venous thromboembolism]. 61
33081917 2020
46
The vascular side of COVID-19 disease. Position paper of the International Union of Angiology. 61
32892615 2020
47
Post-COVID-19 Syndrome (PC19S): Chronic Reactive Endotheliitis and Disseminated Vascular Disease. 61
33496258 2020
48
The Interplay Between Coagulation and Inflammation Pathways in COVID-19-Associated Respiratory Failure: A Narrative Review. 61
32844302 2020
49
Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses. 61
33310781 2020
50
Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis. 61
33023827 2020

Variations for Endotheliitis

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 CXCL9 CXCL11 CXCL10
2
Show member pathways
12.95 CXCL9 CXCL11 CXCL10
3
Show member pathways
12.79 CXCL9 CXCL11 CXCL10
4
Show member pathways
12.78 CXCL9 CXCL11 CXCL10
5
Show member pathways
12.65 CXCL9 CXCL11 CXCL10
6
Show member pathways
12.54 CXCL9 CXCL11 CXCL10
7
Show member pathways
12.26 CXCL9 CXCL11 CXCL10
8
Show member pathways
11.65 CXCL11 CXCL10
9
Show member pathways
11.47 CXCL9 CXCL11 CXCL10
10 10.72 CXCL9 CXCL10
11 10.34 CXCL9 CXCL11 CXCL10
12 10.33 CXCL9 CXCL11 CXCL10

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CXCL9 CXCL10
2 extracellular space GO:0005615 8.8 CXCL9 CXCL11 CXCL10

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.74 CXCL9 CXCL11 CXCL10
2 G protein-coupled receptor signaling pathway GO:0007186 9.72 CXCL9 CXCL11 CXCL10
3 immune response GO:0006955 9.7 CXCL9 CXCL11 CXCL10
4 inflammatory response GO:0006954 9.69 CXCL9 CXCL11 CXCL10
5 cell-cell signaling GO:0007267 9.67 CXCL9 CXCL11 CXCL10
6 regulation of cell proliferation GO:0042127 9.63 CXCL9 CXCL11 CXCL10
7 cellular response to lipopolysaccharide GO:0071222 9.61 CXCL9 CXCL11 CXCL10
8 chemotaxis GO:0006935 9.58 CXCL9 CXCL11 CXCL10
9 defense response to virus GO:0051607 9.56 CXCL9 CXCL10
10 response to bacterium GO:0009617 9.54 CXCL9 CXCL10
11 defense response GO:0006952 9.54 CXCL9 CXCL11 CXCL10
12 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.5 CXCL9 CXCL11 CXCL10
13 T cell chemotaxis GO:0010818 9.48 CXCL11 CXCL10
14 neutrophil chemotaxis GO:0030593 9.43 CXCL9 CXCL11 CXCL10
15 chemokine-mediated signaling pathway GO:0070098 9.33 CXCL9 CXCL11 CXCL10
16 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.13 CXCL9 CXCL11 CXCL10
17 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 8.8 CXCL9 CXCL11 CXCL10

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CXCL9 CXCL11 CXCL10
2 chemokine activity GO:0008009 9.33 CXCL9 CXCL11 CXCL10
3 heparin binding GO:0008201 9.32 CXCL11 CXCL10
4 CXCR chemokine receptor binding GO:0045236 9.13 CXCL9 CXCL11 CXCL10
5 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL9 CXCL11 CXCL10

Sources for Endotheliitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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