MCID: END072
MIFTS: 39

Endotheliitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis 60

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 60  
Rare eye diseases


External Ids:

Orphanet 60 ORPHA137602

Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to carrion's disease and encephalitis. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Ganciclovir and Difluprednate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, heart and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Endotheliitis is an immune response within endothelium in blood vessels, in which they become inflamed. ... more...

Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1542)
# Related Disease Score Top Affiliating Genes
1 carrion's disease 31.2 CXCL10 CXCL9
2 encephalitis 29.5 CXCL10 CXCL9
3 pulmonary fibrosis, idiopathic 29.4 CXCL10 CXCL9
4 multiple sclerosis 29.3 CXCL10 CXCL11
5 cryoglobulinemia 28.9 CXCL10 CXCL11
6 mycobacterium tuberculosis 1 28.7 CXCL10 CXCL9
7 mycosis fungoides 28.6 CXCL10 CXCL11 CXCL9
8 tick-borne encephalitis 28.6 CXCL10 CXCL11
9 corneal endothelial dystrophy 12.7
10 fuchs' endothelial dystrophy 12.7
11 corneal dystrophy, fuchs endothelial, 1 12.6
12 corneal dystrophy, fuchs endothelial, 3 12.6
13 corneal dystrophy, fuchs endothelial, 4 12.5
14 corneal dystrophy, fuchs endothelial, 6 12.5
15 corneal endothelial dystrophy type 2 12.5
16 intravascular papillary endothelial hyperplasia 12.4
17 iridocorneal endothelial syndrome 12.4
18 corneal dystrophy, fuchs endothelial, 2 12.4
19 corneal dystrophy, fuchs endothelial, 8 12.4
20 corneal dystrophy, fuchs endothelial, 5 12.3
21 corneal dystrophy, endothelial, x-linked 12.3
22 congenital hereditary endothelial dystrophy type i 12.2
23 corneal dystrophy, fuchs endothelial, 7 12.1
24 corneal dystrophy, posterior polymorphous, 1 12.1
25 endothelial dystrophy, congenital hereditary, with nail hypoplasia 12.0
26 corneal dystrophy and perceptive deafness 11.9
27 edict syndrome 11.8
28 spotted fever 11.4
29 lymphangiosarcoma 11.4
30 hemangioma, capillary infantile 11.4
31 pulmonary hypertension, primary, 1 11.3
32 hemangioma 11.3
33 bullous keratopathy 11.3
34 cytokine deficiency 11.3
35 cerebral cavernous malformations 11.3
36 arteriovenous malformations of the brain 11.2
37 hepatic veno-occlusive disease 11.2
38 epidemic typhus 11.2
39 angioimmunoblastic t-cell lymphoma 11.2
40 essential iris atrophy 11.2
41 macular dystrophy, corneal 11.2
42 aneurysmal bone cysts 11.2
43 heme oxygenase 1 deficiency 11.2
44 susac syndrome 11.2
45 capillary malformations, congenital 11.2
46 hepatic lipase deficiency 11.1
47 vascular hemostatic disease 11.1
48 kanzaki disease 11.1
49 corneal dystrophy, congenital stromal 11.1
50 cogan-reese syndrome 11.1

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis

Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.32 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 CXCL10 CXCL11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.32 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 CXCL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.32 CXCL11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CXCL11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.32 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 CXCL10

Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 82410-32-0 3454
2
Difluprednate Approved Phase 4 23674-86-4 443936
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Acyclovir Approved Phase 4 59277-89-3 2022
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
9 Ganciclovir triphosphate Phase 4,Phase 2,Phase 3,Not Applicable
10 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Not Applicable
11 Antiviral Agents Phase 4,Phase 2,Phase 3,Not Applicable
12 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
13 Ophthalmic Solutions Phase 4
14 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3
15 Methylprednisolone Acetate Phase 4
16 valacyclovir Phase 4
17 Prednisolone acetate Phase 4
18
Valganciclovir Approved, Investigational Phase 2, Phase 3 175865-60-8 64147

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
2 Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
3 Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes Not yet recruiting NCT03586284 Phase 2, Phase 3 Valganciclovir Hydrochloride;Ganciclovir Sodium;Placebo Oral Tablet;Topical placebo
4 Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis Unknown status NCT01359995
5 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Not Applicable Ganciclovir

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

42
Endothelial, Heart, Bone, Thyroid, T Cells, Liver, Brain

Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 102)
# Title Authors Year
1
The Effect of Topical Ganciclovir and Corticosteroid on Cytomegalovirus Corneal Endotheliitis in Korean Patients. ( 29953306 )
2019
2
Topical Ganciclovir for Prophylaxis of Cytomegalovirus Endotheliitis in Endothelial Keratoplasty. ( 30379718 )
2019
3
Human Herpesvirus-6 corneal Endotheliitis after intravitreal injection of Ranibizumab. ( 30651089 )
2019
4
Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report. ( 30653172 )
2019
5
Clinical Evaluation of Intravitreal Injection of Ganciclovir in Refractory Corneal Endotheliitis. ( 30806530 )
2019
6
A Review of Corneal Endotheliitis and Endotheliopathy: Differential Diagnosis, Evaluation, and Treatment. ( 30859513 )
2019
7
Recurrence of herpes simplex virus endotheliitis in a Descemet membrane endothelial keratoplasty graft: mimicking fungal interface infection. ( 31064790 )
2019
8
Acute onset of autoimmune hepatitis with sinusoidal and central vein endotheliitis, and marked involvement of activated dendritic cells: A case report. ( 30593193 )
2018
9
Incidence and Risk Factors of New Onset Endotheliitis After Cataract Surgery. ( 30372749 )
2018
10
Clinical features, diagnosis and treatment outcomes of cytomegalovirus endotheliitis in Hong Kong. ( 27306329 )
2018
11
Acute Bilateral Toxic Endotheliitis Following Alcohol Consumption. ( 27494457 )
2018
12
Descemet membrane endothelial keratoplasty for corneal decompensation caused by herpes simplex virus endotheliitis. ( 29502597 )
2018
13
Role of Dendritic Cells and Inflammatory Cells in Herpetic Endotheliitis: Analysis Using In Vivo Confocal Microscopy. ( 29543663 )
2018
14
Fungal corneal endotheliitis: a series of case reports. ( 29977824 )
2018
15
Clinical Results and Utility of Herpesviruses Multiplex Polymerase Chain Reaction: Assessment of Aqueous Humor Samples From Patients With Corneal Endotheliitis and High Intraocular Pressure. ( 30234744 )
2018
16
Clinical Manifestations and Characteristics of In Vivo Confocal Microscopy in Varicella Zoster Virus-Related Corneal Endotheliitis. ( 30252558 )
2018
17
Cytomegalovirus Corneal Endotheliitis After Descemet Membrane Endothelial Keratoplasty. ( 30614903 )
2018
18
Cerebral adenovirus endotheliitis presenting as posterior reversible encephalopathy syndrome after allogeneic stem cell transplantation. ( 28692025 )
2017
19
The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis. ( 27142389 )
2017
20
Descemet Stripping Automated Endothelial Keratoplasty Outcomes in Patients With Cytomegalovirus Endotheliitis. ( 27661068 )
2017
21
Clinical Findings of Anterior Segment Spectral Domain Optical Coherence Tomography Images in Cytomegalovirus Corneal Endotheliitis. ( 27941387 )
2017
22
Sinusoidal endotheliitis as a histological parameter for diagnosing acute liver allograft rejection. ( 28223723 )
2017
23
CMV endotheliitis: a cause for recurrent failed corneal transplant. ( 29326863 )
2017
24
Rare Anterior Segment Retinoblastoma Masquerading as Corneal Endotheliitis. ( 25961779 )
2016
25
Long-Term Topical Ganciclovir and Corticosteroids Preserve Corneal Endothelial Function in Cytomegalovirus Corneal Endotheliitis. ( 26967107 )
2016
26
Differential Changes in Intraocular Pressure and Corneal Manifestations in Individuals With Viral Endotheliitis After Keratoplasty. ( 26967113 )
2016
27
Multiple parallel-line endotheliitis: case report and literature review of an emerging entity. ( 27316289 )
2016
28
Activation of Cytomegalovirus corneal endotheliitis following laser in situ keratomileusis. ( 27899387 )
2016
29
Management of recurrent acute bilateral corneal endotheliitis monitored by serial corneal pachymetry. ( 28050086 )
2016
30
Clinical features and management of cytomegalovirus corneal endotheliitis: analysis of 106 cases from the Japan corneal endotheliitis study. ( 25075122 )
2015
31
Polymorphisms in cytomegalovirus genotype in immunocompetent patients with corneal endotheliitis or iridocyclitis. ( 25963863 )
2015
32
Herpes Simplex Virus Endotheliitis following Descemet's Membrane Endothelial Keratoplasty. ( 26425323 )
2015
33
In Vivo Confocal Microscopy Use in Endotheliitis. ( 26540476 )
2015
34
A case of corneal endothelial dysfunction due to coxsackievirus A24 corneal endotheliitis after cataract surgery. ( 24608251 )
2014
35
Acute Idiopathic Endotheliitis Early After Corneal Cross-linking With Riboflavin and Ultraviolet-A. ( 24699560 )
2014
36
Review of clinical and basic approaches to corneal endotheliitis. ( 25170583 )
2014
37
In vivo imaging of coin-shaped lesions in cytomegalovirus corneal endotheliitis by anterior segment optical coherence tomography. ( 25285587 )
2014
38
An atypical case of herpes simplex virus endotheliitis presented as bullous keratopathy. ( 23957427 )
2013
39
Topical ganciclovir treatment in patients with cytomegalovirus endotheliitis receiving penetrating keratoplasty. ( 23009154 )
2013
40
Mapping owl's eye cells of patients with cytomegalovirus corneal endotheliitis using in vivo laser confocal microscopy. ( 23124832 )
2013
41
Identification of cytomegalovirus and human herpesvirus-6 DNA in a patient with corneal endotheliitis. ( 23247975 )
2013
42
A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR. ( 23252654 )
2013
43
Progressive cicatrizing endotheliitis associated with leucocytoclastic vasculitis and Crohn disease. ( 23514527 )
2013
44
A case of CMV endotheliitis treated with intravitreal ganciclovir injection. ( 23543604 )
2013
45
Outcomes of corneal transplantation for irreversible corneal decompensation secondary to corneal endotheliitis in Asian eyes. ( 23622566 )
2013
46
Concomitant herpes simplex virus and cytomegalovirus endotheliitis in immunocompetent patient. ( 23667217 )
2013
47
Bilateral lineal endotheliitis: case report. ( 23828474 )
2013
48
Infectious endotheliitis: a rare case of presumed mycotic origin. ( 23901253 )
2013
49
Cytomegalovirus-related corneal endotheliitis: A review article. ( 23964187 )
2013
50
Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with rift valley fever virus. ( 21601870 )
2012

Variations for Endotheliitis

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 CXCL10 CXCL11 CXCL9
2
Show member pathways
12.99 CXCL10 CXCL11 CXCL9
3
Show member pathways
12.85 CXCL10 CXCL11 CXCL9
4
Show member pathways
12.82 CXCL10 CXCL11 CXCL9
5
Show member pathways
12.72 CXCL10 CXCL11 CXCL9
6
Show member pathways
12.57 CXCL10 CXCL11 CXCL9
7
Show member pathways
12.37 CXCL10 CXCL11 CXCL9
8
Show member pathways
11.71 CXCL10 CXCL11
9
Show member pathways
11.68 CXCL10 CXCL11 CXCL9
10
Show member pathways
11.4 CXCL10 CXCL11 CXCL9
11 10.98 CXCL10 CXCL11 CXCL9
12 10.89 CXCL10 CXCL9
13 10.66 CXCL10 CXCL11 CXCL9
14 10.45 CXCL10 CXCL11 CXCL9
15 10.33 CXCL10 CXCL11 CXCL9

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CXCL10 CXCL9
2 extracellular space GO:0005615 8.8 CXCL10 CXCL11 CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.76 CXCL10 CXCL11 CXCL9
2 G protein-coupled receptor signaling pathway GO:0007186 9.74 CXCL10 CXCL11 CXCL9
3 immune response GO:0006955 9.72 CXCL10 CXCL11 CXCL9
4 regulation of signaling receptor activity GO:0010469 9.71 CXCL10 CXCL11 CXCL9
5 inflammatory response GO:0006954 9.7 CXCL10 CXCL11 CXCL9
6 cell-cell signaling GO:0007267 9.69 CXCL10 CXCL11 CXCL9
7 regulation of cell proliferation GO:0042127 9.65 CXCL10 CXCL11 CXCL9
8 cellular response to lipopolysaccharide GO:0071222 9.63 CXCL10 CXCL11 CXCL9
9 chemotaxis GO:0006935 9.61 CXCL10 CXCL11 CXCL9
10 defense response to virus GO:0051607 9.58 CXCL10 CXCL9
11 defense response GO:0006952 9.58 CXCL10 CXCL11 CXCL9
12 response to bacterium GO:0009617 9.56 CXCL10 CXCL9
13 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.54 CXCL10 CXCL11 CXCL9
14 neutrophil chemotaxis GO:0030593 9.5 CXCL10 CXCL11 CXCL9
15 T cell chemotaxis GO:0010818 9.49 CXCL10 CXCL11
16 chemokine-mediated signaling pathway GO:0070098 9.43 CXCL10 CXCL11 CXCL9
17 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.33 CXCL10 CXCL11 CXCL9
18 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.13 CXCL10 CXCL11 CXCL9
19 leukocyte chemotaxis GO:0030595 8.8 CXCL10 CXCL11 CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CXCL10 CXCL9
2 heparin binding GO:0008201 9.16 CXCL10 CXCL11
3 chemokine activity GO:0008009 9.13 CXCL10 CXCL11 CXCL9
4 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL10 CXCL11 CXCL9

Sources for Endotheliitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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