MCID: END072
MIFTS: 45

Endotheliitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Endotheliitis

MalaCards integrated aliases for Endotheliitis:

Name: Endotheliitis 59

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA137602

Summaries for Endotheliitis

MalaCards based summary : Endotheliitis is related to carrion's disease and encephalitis. An important gene associated with Endotheliitis is CXCL10 (C-X-C Motif Chemokine Ligand 10), and among its related pathways/superpathways are PEDF Induced Signaling and Peptide ligand-binding receptors. The drugs Ganciclovir and Ganciclovir triphosphate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, monocytes and brain, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Endotheliitis is an immune response within endothelium in blood vessels, in which they become inflamed.... more...

Related Diseases for Endotheliitis

Diseases related to Endotheliitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1190)
# Related Disease Score Top Affiliating Genes
1 carrion's disease 30.8 CXCL10 CXCL9
2 encephalitis 28.9 CXCL10 CXCL9
3 psoriasis 28.8 CXCL10 CXCL9
4 alopecia areata 28.8 CXCL10 CXCL9
5 pulmonary fibrosis, idiopathic 28.6 CXCL10 CXCL9
6 cryoglobulinemia 28.4 CXCL10 CXCL11
7 multiple sclerosis 28.2 CXCL10 CXCL11 CXCL9
8 mycosis fungoides 27.6 CXCL10 CXCL11 CXCL9
9 fuchs' endothelial dystrophy 12.5
10 corneal endothelial dystrophy 12.5
11 corneal dystrophy, fuchs endothelial, 1 12.4
12 corneal endothelial dystrophy type 2 12.3
13 corneal dystrophy, fuchs endothelial, 3 12.3
14 intravascular papillary endothelial hyperplasia 12.3
15 corneal dystrophy, fuchs endothelial, 4 12.2
16 corneal dystrophy, fuchs endothelial, 6 12.2
17 iridocorneal endothelial syndrome 12.2
18 corneal dystrophy, fuchs endothelial, 2 12.2
19 corneal dystrophy, fuchs endothelial, 8 12.2
20 corneal dystrophy, fuchs endothelial, 5 12.1
21 corneal dystrophy, endothelial, x-linked 12.1
22 congenital hereditary endothelial dystrophy type i 12.0
23 corneal dystrophy, fuchs endothelial, 7 11.9
24 corneal dystrophy, posterior polymorphous, 1 11.9
25 endothelial dystrophy, congenital hereditary, with nail hypoplasia 11.8
26 edict syndrome 11.6
27 corneal dystrophy and perceptive deafness 11.5
28 spotted fever 11.2
29 lymphangiosarcoma 11.2
30 hemangioma 11.1
31 bullous keratopathy 11.1
32 pulmonary hypertension, primary, 1 11.1
33 cerebral cavernous malformations 11.1
34 hemolytic-uremic syndrome 11.1
35 angioimmunoblastic t-cell lymphoma 11.0
36 heme oxygenase 1 deficiency 11.0
37 susac syndrome 11.0
38 macular dystrophy, corneal 11.0
39 hepatic veno-occlusive disease 11.0
40 aneurysmal bone cysts 11.0
41 essential iris atrophy 11.0
42 capillary malformations, congenital 11.0
43 hepatic lipase deficiency 11.0
44 hemangioma, capillary infantile 11.0
45 kanzaki disease 10.9
46 corneal dystrophy, congenital stromal 10.9
47 lung cancer 10.9
48 high molecular weight kininogen deficiency 10.7
49 pulmonary hypertension, primary, 2 10.7
50 gapo syndrome 10.7

Graphical network of the top 20 diseases related to Endotheliitis:



Diseases related to Endotheliitis

Symptoms & Phenotypes for Endotheliitis

GenomeRNAi Phenotypes related to Endotheliitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.32 CXCL11
2 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.32 CXCL10 CXCL11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.32 CXCL11
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.32 CXCL10
5 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.32 CXCL11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.32 CXCL11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.32 CXCL10
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.32 CXCL11
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.32 CXCL10

Drugs & Therapeutics for Endotheliitis

Drugs for Endotheliitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ganciclovir Approved, Investigational Phase 4,Not Applicable 82410-32-0 3454
2 Ganciclovir triphosphate Phase 4,Not Applicable
3 Nucleic Acid Synthesis Inhibitors Phase 4,Not Applicable
4 Anti-Infective Agents Phase 4,Not Applicable
5 Antiviral Agents Phase 4,Not Applicable
6 Tetrahydrozoline Phase 4
7 Ophthalmic Solutions Phase 4
8 Pharmaceutical Solutions Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis Recruiting NCT02943057 Phase 4 2% guttae ganciclovir
2 Topical Ganciclovir in Patients Receiving Penetrating Keratoplasty With Cytomegalovirus Endotheliitis Unknown status NCT01359995
3 Topical Administration of 0.15% Ganciclovir Gel for CMV Anterior Uveitis / Endotheliitis Completed NCT01647529 Not Applicable Ganciclovir

Search NIH Clinical Center for Endotheliitis

Genetic Tests for Endotheliitis

Anatomical Context for Endotheliitis

MalaCards organs/tissues related to Endotheliitis:

41
Endothelial, Monocytes, Brain, Lung, Breast, Neutrophil, Smooth Muscle

Publications for Endotheliitis

Articles related to Endotheliitis:

(show top 50) (show all 27512)
# Title Authors Year
1
Modeling and rescue of defective blood-brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients. ( 29615068 )
2018
2
Fusion-Negative Rhabdomyosarcoma Can Arise from Endothelial Cells. ( 29352048 )
2018
3
Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )
2018
4
MACULAR ATROPHY INCIDENCE IN ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR-TREATED NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: Risk Factor Evaluation for Individualized Treatment Need of Ranibizumab or Aflibercept According to an Observe-and-Plan Regimen. ( 29370035 )
2018
5
Descemet membrane endothelial keratoplasty for corneal decompensation caused by herpes simplex virus endotheliitis. ( 29502597 )
2018
6
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity. ( 29114076 )
2018
7
Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin. ( 29462613 )
2018
8
Transcriptional Analysis of Endothelial Cell Alternation Induced by Atrial Natriuretic Polypeptide in Human Umbilical Vein Endothelial Cells. ( 29279524 )
2018
9
Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. ( 29677349 )
2018
10
Hyperuricemia and Progression of Chronic Kidney Disease: Role of Phenotype Transition of Renal Tubular and Endothelial Cells. ( 29393109 )
2018
11
Vascular endothelial growth factor and pulmonary hypertension in children with beta thalassemia major. ( 29859904 )
2018
12
Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors. ( 29316425 )
2018
13
Vascular targeting of LIGHT normalizes blood vessels in primary brain cancer and induces intratumoural high endothelial venules. ( 29603739 )
2018
14
TRPV4 regulates migration and tube formation of human retinal capillary endothelial cells. ( 29433476 )
2018
15
Arginine administration increases circulating endothelial progenitor cells and attenuates tissue injury in a mouse model of hind limb ischemia/reperfusion. ( 29960153 )
2018
16
Vascular Endothelial Growth Factor Inhibitor Therapy and Cardiovascular and Renal Damage in Renal Cell Carcinoma. ( 28676023 )
2018
17
Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis. ( 29872403 )
2018
18
Corneal endothelial alterations in alcohol dependence syndrome. ( 29305345 )
2018
19
Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan. ( 29102546 )
2018
20
Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization. ( 29945770 )
2018
21
Biomarkers of vascular injury and endothelial dysfunction after recent glucose intolerance in pregnancy. ( 29871496 )
2018
22
Analysis of candidate genes ZEB1 and LOXHD1 in late-onset Fuchs' endothelial corneal dystrophy in an Indian cohort. ( 29799290 )
2018
23
Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis. ( 29980767 )
2018
24
Vascular Endothelial Growth Factor-A165b Restores Normal Glomerular Water Permeability in a Diphtheria-Toxin Mouse Model of Glomerular Injury. ( 29393270 )
2018
25
The long non-coding RNA MALAT1 activates Nrf2 signaling to protect human umbilical vein endothelial cells from hydrogen peroxide. ( 29274336 )
2018
26
Sinusoidal hemangioma and intravascular papillary endothelial hyperplasia: Interrelated processes that share a histogenetic piecemeal angiogenic mechanism. ( 29486986 )
2018
27
Tanshinone I prevents atorvastatin-induced cerebral hemorrhage in zebrafish and stabilizes endothelial cell-cell adhesion by inhibiting VE-cadherin internalization and actin-myosin contractility. ( 29017932 )
2018
28
Anti-Vascular Endothelial Growth Factor Therapy in Diabetic Macular Edema: Does Flavor Matter? ( 29392302 )
2018
29
Role of Dendritic Cells and Inflammatory Cells in Herpetic Endotheliitis: Analysis Using In Vivo Confocal Microscopy. ( 29543663 )
2018
30
An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. ( 29630665 )
2018
31
A mixed form of intravascular papillary endothelial hyperplasia in an uncommon location: case and literature review. ( 29630155 )
2018
32
Insulinlike Growth Factor-Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance. ( 29186427 )
2018
33
Survivin regulated by autophagy mediates hyperglycemia-induced vascular endothelial cell dysfunction. ( 29391151 )
2018
34
Visual Outcomes Based on Early Response to Anti-Vascular Endothelial Growth Factor Treatment for Diabetic Macular Edema. ( 29316563 )
2018
35
TOPICAL DORZOLAMIDE-TIMOLOL WITH INTRAVITREOUS ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR FOR RETINAL VEIN OCCLUSION: A PILOT STUDY. ( 29864044 )
2018
36
An intravascular papillary endothelial hyperplasia of the hand radiologically mimicking a hemangiopericytoma: A case report and literature review. ( 29348916 )
2018
37
Gene Editing as a Potential Therapeutic Solution for Fuchs Endothelial Corneal Dystrophy: The Future Is Clearer. ( 29931030 )
2018
38
Endothelial Robo4 regulates IL-6 production by endothelial cells and monocytes via a crosstalk mechanism in inflammation. ( 29137978 )
2018
39
Impaired Endothelial Function in Hereditary Angioedema During the Symptom-Free Period. ( 29867566 )
2018
40
Endothelial JAK2<sup>V617F</sup>does not enhance liver lesions in mice with Budd-Chiari syndrome. ( 29360553 )
2018
41
The relationship between the levels and function of endothelial progenitor cells and factor V Leiden and protein C deficiency in patients with primary Budd-Chiari syndrome. ( 29771426 )
2018
42
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
43
Associations between endothelial progenitor cells, clinical characteristics and coronary restenosis in patients undergoing percutaneous coronary artery intervention. ( 29739448 )
2018
44
Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models. ( 29698634 )
2018
45
Developmental endothelial locus-1 (Del-1) antagonizes Interleukin-17-mediated allergic asthma. ( 29437247 )
2018
46
Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy. ( 29531856 )
2018
47
Outcomes of conventional phacoemulsification versus femtosecond laser-assisted cataract surgery in eyes with Fuchs endothelial corneal dystrophy. ( 29773458 )
2018
48
Phosphatidylserine-exposing blood and endothelial cells contribute to the hypercoagulable state in essential thrombocythemia patients. ( 29332224 )
2018
49
The association between oxidative stress and endothelial dysfunction in early childhood patients with Kawasaki disease. ( 29426283 )
2018
50
MicroRNA-19 restores vascular endothelial cell function in lower limb ischemia-reperfusion injury through the KLF10-dependent TGF-I^1/Smad signaling pathway in rats. ( 29953651 )
2018

Variations for Endotheliitis

Expression for Endotheliitis

Search GEO for disease gene expression data for Endotheliitis.

Pathways for Endotheliitis

Pathways related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CXCL10 CXCL11 CXCL9
2
Show member pathways
12.92 CXCL10 CXCL11 CXCL9
3
Show member pathways
12.77 CXCL10 CXCL11 CXCL9
4
Show member pathways
12.76 CXCL10 CXCL11 CXCL9
5
Show member pathways
12.61 CXCL10 CXCL11 CXCL9
6
Show member pathways
12.35 CXCL10 CXCL11 CXCL9
7
Show member pathways
12.19 CXCL10 CXCL11 CXCL9
8
Show member pathways
11.62 CXCL10 CXCL11
9
Show member pathways
11.2 CXCL10 CXCL11 CXCL9
10 10.72 CXCL10 CXCL9
11 10.33 CXCL10 CXCL11 CXCL9

GO Terms for Endotheliitis

Cellular components related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CXCL10 CXCL9
2 extracellular space GO:0005615 8.8 CXCL10 CXCL11 CXCL9

Biological processes related to Endotheliitis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.74 CXCL10 CXCL11 CXCL9
2 G-protein coupled receptor signaling pathway GO:0007186 9.72 CXCL10 CXCL11 CXCL9
3 immune response GO:0006955 9.71 CXCL10 CXCL11 CXCL9
4 regulation of signaling receptor activity GO:0010469 9.7 CXCL10 CXCL11 CXCL9
5 inflammatory response GO:0006954 9.69 CXCL10 CXCL11 CXCL9
6 cell-cell signaling GO:0007267 9.67 CXCL10 CXCL11 CXCL9
7 regulation of cell proliferation GO:0042127 9.65 CXCL10 CXCL11 CXCL9
8 response to lipopolysaccharide GO:0032496 9.63 CXCL10 CXCL11 CXCL9
9 chemotaxis GO:0006935 9.61 CXCL10 CXCL11 CXCL9
10 defense response GO:0006952 9.58 CXCL10 CXCL11 CXCL9
11 defense response to virus GO:0051607 9.56 CXCL10 CXCL9
12 chemokine-mediated signaling pathway GO:0070098 9.54 CXCL10 CXCL11 CXCL9
13 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.5 CXCL10 CXCL11 CXCL9
14 positive regulation of leukocyte chemotaxis GO:0002690 9.43 CXCL10 CXCL11 CXCL9
15 positive regulation of cAMP-mediated signaling GO:0043950 9.33 CXCL10 CXCL11 CXCL9
16 positive regulation of cAMP metabolic process GO:0030816 9.13 CXCL10 CXCL11 CXCL9
17 T cell chemotaxis GO:0010818 8.8 CXCL10 CXCL11 CXCL9

Molecular functions related to Endotheliitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CXCL10 CXCL11 CXCL9
2 chemokine activity GO:0008009 9.33 CXCL10 CXCL11 CXCL9
3 heparin binding GO:0008201 9.32 CXCL10 CXCL11
4 CXCR chemokine receptor binding GO:0045236 9.13 CXCL10 CXCL11 CXCL9
5 CXCR3 chemokine receptor binding GO:0048248 8.8 CXCL10 CXCL11 CXCL9

Sources for Endotheliitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....