MCID: ENG004
MIFTS: 34

Engraftment Syndrome

Categories: Rare diseases

Aliases & Classifications for Engraftment Syndrome

MalaCards integrated aliases for Engraftment Syndrome:

Name: Engraftment Syndrome 54 74

Classifications:



External Ids:

UMLS 74 C0919746

Summaries for Engraftment Syndrome

MalaCards based summary : Engraftment Syndrome is related to capillary leak syndrome and leukemia, acute myeloid. An important gene associated with Engraftment Syndrome is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and IL-17 Family Signaling Pathways. The drugs tannic acid and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and myeloid.

Related Diseases for Engraftment Syndrome

Diseases related to Engraftment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 31.8 CSF2 CXCL8
2 leukemia, acute myeloid 29.3 ABCB1 CSF2 CSF3
3 bacterial infectious disease 29.3 CSF2 CSF3 CXCL8
4 myeloma, multiple 29.1 ABCB1 CSF2 CSF3 CXCL8 IFNA1
5 hematopoietic stem cell transplantation 10.3
6 clopidogrel resistance 10.2 ABCB1 CYP3A5
7 vaginitis 10.2 ABCB1 CXCL8
8 graft-versus-host disease 10.1
9 trichosporonosis 10.1 CSF2 CSF3
10 parathyroid adenoma 10.1 ABCB1 CALCA
11 aseptic meningitis 10.1 CALCA CXCL8
12 granulocytopenia 10.1 CSF2 CSF3
13 bacterial sepsis 10.1 CALCA CXCL8
14 anemia of prematurity 10.1 CSF2 CSF3
15 bacterial pneumonia 10.1 CALCA CXCL8
16 ecthyma 10.1 CSF2 CSF3
17 small cell cancer of the lung 10.0 ABCB1 CALCA CSF3
18 acute monoblastic leukemia 10.0 CSF2 CXCL8
19 severe acute respiratory syndrome 10.0 CXCL8 IFNA1
20 meconium aspiration syndrome 10.0 CSF2 CXCL8
21 leukocyte disease 10.0 CSF2 CSF3
22 spondylocarpotarsal synostosis syndrome 10.0
23 acute graft versus host disease 10.0
24 gastroenteritis 10.0 CXCL8 IFNA1
25 pancytopenia 10.0 CSF2 CSF3
26 impetigo 10.0 CALCA PI3
27 erysipelas 10.0 CALCA PI3
28 stomatitis 10.0 CSF2 CSF3
29 poems syndrome 9.9
30 mastitis 9.9 CSF2 CXCL8
31 mucositis 9.9 ABCB1 CSF2 CSF3
32 murray valley encephalitis 9.9 IFNA1 PI3
33 bronchial disease 9.9 CSF2 CXCL8
34 hematologic cancer 9.9 ABCB1 CSF2 CSF3
35 lymphoma, non-hodgkin, familial 9.9 ABCB1 CSF2 CSF3
36 acute respiratory distress syndrome 9.9 CXCL8 PI3
37 felty syndrome 9.8 CSF2 CSF3 CXCL8
38 cyclic neutropenia 9.8 CSF2 CSF3 CXCL8
39 neutropenia 9.8 CSF2 CSF3 IFNA1
40 severe congenital neutropenia 9.8 CSF2 CSF3
41 bone marrow cancer 9.8 CSF2 CSF3 IFNA1
42 monocytic leukemia 9.8 CSF2 CXCL8
43 extrinsic allergic alveolitis 9.8 CXCL8 PI3
44 acquired immunodeficiency syndrome 9.8 CSF2 IFNA1
45 renal cell carcinoma, nonpapillary 9.8 ABCB1 CSF2 IFNA1
46 kaposi sarcoma 9.7 CSF2 CXCL8 IFNA1
47 acute lymphocytic leukemia 9.7 CSF2 CSF3
48 breast cancer 9.7
49 multiple sclerosis 9.7
50 keratitis, hereditary 9.7

Graphical network of the top 20 diseases related to Engraftment Syndrome:



Diseases related to Engraftment Syndrome

Symptoms & Phenotypes for Engraftment Syndrome

Drugs & Therapeutics for Engraftment Syndrome

Drugs for Engraftment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 3 1401-55-4
2
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
3
Mycophenolic acid Approved Phase 3,Phase 2,Phase 1 24280-93-1 446541
4
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Fludarabine Approved Phase 3,Phase 1,Phase 2 75607-67-9, 21679-14-1 30751
7
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
8
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
9 Immunosuppressive Agents Phase 3,Phase 2
10 Cyclosporins Phase 3,Phase 2
11 Vidarabine Phosphate Phase 3
12 Antibiotics, Antitubercular Phase 3,Phase 2
13 Antiviral Agents Phase 3
14 Antineoplastic Agents, Alkylating Phase 3,Phase 2
15 Antimetabolites, Antineoplastic Phase 3,Phase 2
16 Alkylating Agents Phase 3,Phase 2
17 Dermatologic Agents Phase 3,Phase 2
18 Antitubercular Agents Phase 3,Phase 2
19 Antifungal Agents Phase 3,Phase 2
20 Antimetabolites Phase 3,Phase 2
21 Calcineurin Inhibitors Phase 3
22 Anti-Infective Agents Phase 3,Phase 2
23 Anti-Bacterial Agents Phase 3,Phase 2
24 Antirheumatic Agents Phase 3,Phase 2,Phase 1
25 Immunologic Factors Phase 3,Phase 2,Phase 1
26
Adenosine Approved, Investigational Phase 2 58-61-7 60961
27
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
28
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 5284616 6436030
29
Pentostatin Approved, Investigational Phase 2 53910-25-1 439693 40926
30
Lenograstim Approved, Investigational Phase 2 135968-09-1
31
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
32
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
33
Tacrolimus Approved, Investigational Phase 1, Phase 2,Phase 2 104987-11-3 6473866 445643 439492
34
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
35
Propranolol Approved, Investigational Phase 2 525-66-6 4946
36
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
37
Histamine Approved, Investigational Phase 2 51-45-6 774
38
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
39
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
40
Promethazine Approved, Investigational Phase 2 60-87-7 4927
41
Mesna Approved, Investigational Phase 2 3375-50-6 598
42
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
43
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
44
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
45
Acetaminophen Approved Phase 2 103-90-2 1983
46
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
47
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
48 Tin Fluorides Phase 2
49 Adjuvants, Immunologic Phase 2
50 Antineoplastic Agents, Immunological Phase 1, Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Completed NCT00412360 Phase 3 Cyclophosphamide;Fludarabine;Cyclosporine A;Mycophenolate Mofetil
2 Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney Cancer Completed NCT00923845 Phase 2 Pentostatin;Sirolimus;Cyclophosphamide
3 Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant Completed NCT02668315 Phase 1, Phase 2
4 Allogeneic Stem Cell Transplantationin Relapsed Hematological Malignancy: Early GVHD Prophylaxis Recruiting NCT02593123 Phase 2 mycophenolate mofetil
5 Stem Cell Transplant With or Without Tbo-filgrastim in Treating Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Recruiting NCT03317899 Phase 2 Tbo-filgrastim
6 ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma Recruiting NCT03441958 Phase 1, Phase 2
7 Renal Allograft Tolerance Through Mixed Chimerism Active, not recruiting NCT01780454 Phase 1, Phase 2 MEDI-507;Rituximab
8 Tinostamustine Conditioning and Autologous Stem Cell Active, not recruiting NCT03687125 Phase 1, Phase 2 Treatment with TINOSTAMUSTINE
9 Pilot Study Using Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in Hematopoietic Stem Cell Transplant Recipients Active, not recruiting NCT02420223 Phase 2 Propranolol
10 Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant Active, not recruiting NCT03330795 Phase 1, Phase 2
11 Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases Enrolling by invitation NCT01852370 Phase 1, Phase 2
12 UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia Not yet recruiting NCT03913026 Phase 2
13 BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance Terminated NCT02029638 Phase 2 Fludarabine;Cyclophosphamide;acetaminophen;diphenhydramine;methylprednisolone;MESNA;mycophenolate mofetil;prednisone;filgrastim
14 Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation Recruiting NCT03483324 Phase 1
15 Engraftment Syndrome After Autologous Stem Cell Transplant: Retrospective Review in Patients With Multiple Myeloma Completed NCT01622582

Search NIH Clinical Center for Engraftment Syndrome

Genetic Tests for Engraftment Syndrome

Anatomical Context for Engraftment Syndrome

MalaCards organs/tissues related to Engraftment Syndrome:

42
Bone, Bone Marrow, Myeloid, Kidney, Skin, Monocytes, T Cells

Publications for Engraftment Syndrome

Articles related to Engraftment Syndrome:

(show top 50) (show all 70)
# Title Authors Year
1
Development of pre-engraftment syndrome, but not acute graft-versus-host disease, reduces relapse rate of acute myeloid leukemia after single cord blood transplantation. ( 30771495 )
2019
2
Engraftment syndrome, transplant-associated thrombotic microangiopathy and hemophagocytic syndrome following autologous stem cell transplant in multiple myeloma. ( 31090118 )
2019
3
Case of engraftment syndrome appearing as scratch dermatitis. ( 28983967 )
2018
4
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. ( 29706650 )
2018
5
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. ( 29741437 )
2018
6
Late-onset fever and engraftment syndrome following autologous stem cell transplant: Impact on resource utilization. ( 30027614 )
2018
7
Engraftment Syndrome: Clinical Features and Predictive Factors in Autologous Stem Cell Transplant. ( 30127551 )
2018
8
Procalcitonin as a Biomarker to differentiate Bacterial Infections from Engraftment Syndrome following Autologous Hematopoietic Stem Cell Transplantation for multiple myeloma. ( 30549311 )
2018
9
Procalcitonin and cytokine profiles in engraftment syndrome in pediatric stem cell transplantation. ( 27762068 )
2017
10
Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients. ( 28756243 )
2017
11
High incidence of engraftment syndrome after haploidentical allogeneic stem cell transplantation. ( 26152555 )
2016
12
Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. ( 26526424 )
2016
13
Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients. ( 26740373 )
2016
14
Favorable outcome to glucocorticoid therapy for engraftment syndrome in pediatric autologous hematopoietic cell transplant. ( 26833703 )
2016
15
Evaluation of engraftment syndrome in children following full-matched related donor hematopoietic stem cell transplantations. ( 27103077 )
2016
16
Engraftment syndrome manifesting as acute brachial neuropathy following high-dose chemotherapy for management of plasma cell myeloma. ( 27116896 )
2016
17
Dexamethasone palmitate for patients with engraftment syndrome is associated with favorable outcome for children with hematological malignancy. ( 27376452 )
2016
18
Pre-engraftment syndrome: clinical significance and pathophysiology. ( 27722122 )
2016
19
Infusion-related febrile reaction after haploidentical stem cell transplantation in children is associated with higher rates of engraftment syndrome and acute graft-versus-host disease. ( 26332180 )
2015
20
Engraftment syndrome: double-edged sword of hematopoietic cell transplants. ( 25581406 )
2015
21
Engraftment syndrome, the Emperor's new clothes and the artist formerly known as Prince. ( 25642762 )
2015
22
Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach. ( 26327628 )
2015
23
Pulmonary manifestations of the pre-engraftment syndrome after umbilical cord blood transplantation. ( 24346710 )
2014
24
Engraftment syndrome after allogeneic hematopoietic cell transplantation in adults. ( 24668776 )
2014
25
Engraftment syndrome in hematopoietic stem cell transplantations. ( 24867116 )
2014
26
Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes. ( 24892262 )
2014
27
Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease. ( 23380345 )
2013
28
Peri-engraftment syndrome in allogeneic hematopoietic SCT. ( 23000648 )
2013
29
Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. ( 23334274 )
2013
30
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. ( 23792270 )
2013
31
Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. ( 23806770 )
2013
32
Elafin: a possible new biomarker and immunohistochemical stain for pre-engraftment syndrome. ( 23866880 )
2013
33
Post-autologous hematopoietic SCT engraftment syndrome: a single center experience. ( 21499317 )
2012
34
Pre-engraftment syndrome after unrelated donor umbilical cord blood transplantation in patients with hematologic malignancies. ( 21933279 )
2012
35
Histological features and immune cell changes in skin lesions of engraftment syndrome of children undergoing hematopoietic stem cell transplantation. ( 22207558 )
2012
36
Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. ( 22399264 )
2012
37
Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic SCT. ( 20383212 )
2011
38
Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome. ( 20603623 )
2011
39
Syngeneic donor hematopoietic stem cell transplantation is associated with high rates of engraftment syndrome. ( 20870027 )
2011
40
Engraftment syndrome after hematopoietic stem cell transplantation: high-resolution computed tomography findings in 2 patients. ( 21042224 )
2011
41
Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation. ( 21815185 )
2011
42
Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. ( 19857590 )
2010
43
Colitis secondary to engraftment syndrome in a patient with autologous peripheral blood stem cell transplant. ( 19499337 )
2010
44
Engraftment syndrome after auto-SCT: analysis of diagnostic criteria and risk factors in a large series from a single center. ( 20062097 )
2010
45
Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature. ( 20371446 )
2010
46
Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children. ( 19067915 )
2009
47
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. ( 19509133 )
2009
48
Peripheral blood stem cell transplant for POEMS syndrome is associated with high rates of engraftment syndrome. ( 18221391 )
2008
49
Pre-engraftment syndrome in hematopoietic stem cell transplantation. ( 18303207 )
2008
50
Incidence, predisposing factors, and outcome of engraftment syndrome in pediatric allogeneic stem cell transplant recipients. ( 18342786 )
2008

Variations for Engraftment Syndrome

Expression for Engraftment Syndrome

Search GEO for disease gene expression data for Engraftment Syndrome.

Pathways for Engraftment Syndrome

Pathways related to Engraftment Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.07 CSF2 CSF3 IFNA1
2
Show member pathways
11.97 CSF2 CSF3 CXCL8
3
Show member pathways
11.7 ABCB1 CYP3A5
4 11.51 CSF2 CXCL8
5
Show member pathways
11.46 CSF2 CXCL8
6
Show member pathways
11.37 ABCB1 CYP3A5
7
Show member pathways
11.36 CSF2 CXCL8
8
Show member pathways
11.3 CSF2 CSF3 CXCL8
9 11.24 CSF3 CXCL8
10 11.22 CSF2 CSF3
11 11.03 CSF2 CXCL8
12 11 ABCB1 CYP3A5
13 10.94 CSF2 CSF3
14 10.84 CSF2 CSF3 CXCL8
15 10.82 CSF2 CSF3 CXCL8
16 10.72 CALCA CSF2 CSF3 CXCL8
17 10.58 ABCB1 CYP3A5
18 10.54 ABCB1 CYP3A5
19 10.44 ABCB1 CYP3A5
20 10.26 ABCB1 CYP3A5

GO Terms for Engraftment Syndrome

Cellular components related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CSF2 CSF3 CXCL8 IFNA1
2 extracellular region GO:0005576 9.1 CALCA CSF2 CSF3 CXCL8 IFNA1 PI3

Biological processes related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.33 CSF2 CSF3 CXCL8
2 receptor internalization GO:0031623 9.26 CALCA CXCL8
3 cytokine-mediated signaling pathway GO:0019221 9.26 CSF2 CSF3 CXCL8 IFNA1
4 regulation of signaling receptor activity GO:0010469 9.02 CALCA CSF2 CSF3 CXCL8 IFNA1

Molecular functions related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CSF2 CSF3 CXCL8 IFNA1

Sources for Engraftment Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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