MCID: ENG004
MIFTS: 35

Engraftment Syndrome

Categories: Rare diseases

Aliases & Classifications for Engraftment Syndrome

MalaCards integrated aliases for Engraftment Syndrome:

Name: Engraftment Syndrome 53 73

Classifications:



External Ids:

UMLS 73 C0919746

Summaries for Engraftment Syndrome

MalaCards based summary : Engraftment Syndrome is related to capillary leak syndrome and myeloma, multiple. An important gene associated with Engraftment Syndrome is ABCB1 (ATP Binding Cassette Subfamily B Member 1), and among its related pathways/superpathways are Kaposi's sarcoma-associated herpesvirus infection and Regulation of IFNA signaling. The drugs Vidarabine and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lung.

Related Diseases for Engraftment Syndrome

Diseases related to Engraftment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 31.8 CSF2 CXCL8
2 myeloma, multiple 28.0 ABCB1 CSF2 CSF3 CXCL8 IFNA1
3 trichosporonosis 10.4 CSF2 CSF3
4 vaginitis 10.4 ABCB1 CXCL8
5 sapho syndrome 10.4 CALCA CXCL8
6 chronic neutrophilic leukemia 10.3 CSF3 IFNA1
7 septic arthritis 10.3 CALCA CXCL8
8 anemia of prematurity 10.3 CSF2 CSF3
9 ecthyma 10.3 CSF2 CSF3
10 acute monoblastic leukemia 10.2 CSF2 CXCL8
11 hematopoietic stem cell transplantation 10.2
12 meconium aspiration syndrome 10.2 CSF2 CXCL8
13 parathyroid adenoma 10.2 ABCB1 CALCA
14 pharyngitis 10.2 CSF2 CXCL8
15 clopidogrel resistance 10.1 ABCB1 CYP3A5
16 small cell cancer of the lung 10.1 ABCB1 CALCA CSF3
17 severe acute respiratory syndrome 10.1 CXCL8 IFNA1
18 pancytopenia 10.0 CSF2 CSF3
19 mastitis 10.0 CSF2 CXCL8
20 gastroenteritis 10.0 CXCL8 IFNA1
21 graft-versus-host disease 10.0
22 mucositis 10.0 ABCB1 CSF2 CSF3
23 bronchial disease 10.0 CSF2 CXCL8
24 impetigo 9.9 CALCA PI3
25 erysipelas 9.9 CALCA PI3
26 lymphoma, non-hodgkin, familial 9.9 ABCB1 CSF2 CSF3
27 felty syndrome 9.9 CSF2 CSF3 CXCL8
28 hematologic cancer 9.9 ABCB1 CSF2 CSF3
29 cyclic neutropenia 9.9 CSF2 CSF3 CXCL8
30 respiratory system disease 9.9 CSF2 CXCL8
31 poems syndrome 9.8
32 acute graft versus host disease 9.8
33 leukocyte disease 9.8 CSF2 CSF3 IFNA1
34 leukemia, acute myeloid 9.8 ABCB1 CSF2 CSF3
35 stomatitis 9.8 CSF2 CSF3 IFNA1
36 bone marrow cancer 9.8 CSF2 CSF3 IFNA1
37 monocytic leukemia 9.8 CSF2 CXCL8
38 acute respiratory distress syndrome 9.8 CXCL8 PI3
39 extrinsic allergic alveolitis 9.7 CXCL8 PI3
40 kaposi sarcoma 9.6 CSF2 CXCL8 IFNA1
41 renal cell carcinoma, nonpapillary 9.6 ABCB1 CSF2 IFNA1
42 multiple sclerosis 9.6
43 aging 9.6
44 myelodysplastic syndrome 9.6
45 colitis 9.6
46 respiratory failure 9.6
47 pericarditis 9.6
48 dermatitis 9.6
49 plasma cell neoplasm 9.6
50 neuropathy 9.6

Graphical network of the top 20 diseases related to Engraftment Syndrome:



Diseases related to Engraftment Syndrome

Symptoms & Phenotypes for Engraftment Syndrome

Drugs & Therapeutics for Engraftment Syndrome

Drugs for Engraftment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vidarabine Approved, Investigational Phase 3 24356-66-9 32326 21704
2
Fludarabine Approved Phase 3,Phase 2 21679-14-1, 75607-67-9 30751
3
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
5
Mycophenolic acid Approved Phase 3,Phase 2 24280-93-1 446541
6
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
7
Mycophenolate mofetil Approved, Investigational Phase 3,Phase 2 128794-94-5 5281078
8 tannic acid Approved, Nutraceutical Phase 3
9
Cobalt Phase 3 7440-48-4 104729
10 Alkylating Agents Phase 3,Phase 2
11 Cyclosporins Phase 3,Phase 2
12 Dermatologic Agents Phase 3,Phase 2
13 Vidarabine Phosphate Phase 3
14 Anti-Bacterial Agents Phase 3,Phase 2
15 Antibiotics, Antitubercular Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 2
17 Anti-Infective Agents Phase 3,Phase 2
18 Antifungal Agents Phase 3,Phase 2
19 Antitubercular Agents Phase 3,Phase 2
20 Antirheumatic Agents Phase 3,Phase 2,Phase 1
21 Antimetabolites Phase 3,Phase 2
22 Antiviral Agents Phase 3
23 Antimetabolites, Antineoplastic Phase 3,Phase 2
24 Calcineurin Inhibitors Phase 3
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2
26
Pentostatin Approved, Investigational Phase 2 53910-25-1 40926 439693
27
Everolimus Approved Phase 2 159351-69-6 6442177
28
Adenosine Approved, Investigational Phase 2 58-61-7 60961
29
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
30
Lenograstim Approved, Investigational Phase 2 135968-09-1
31
Fluticasone Approved, Experimental, Investigational Phase 2 90566-53-3 62924
32
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
33
Propranolol Approved, Investigational Phase 2 525-66-6 4946
34
Mesna Approved, Investigational Phase 2 3375-50-6 598
35
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
36
Acetaminophen Approved Phase 2 103-90-2 1983
37
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
38
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
39
Promethazine Approved, Investigational Phase 2 60-87-7 4927
40
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
41
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
42 Adjuvants, Immunologic Phase 2
43 Tin Fluorides Phase 2
44 JM 3100 Phase 2
45 Adrenergic Agents Phase 2
46 Adrenergic Antagonists Phase 2
47 Adrenergic beta-Antagonists Phase 2
48 Neurotransmitter Agents Phase 2
49 Anti-Arrhythmia Agents Phase 2
50 Vasodilator Agents Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Completed NCT00412360 Phase 3 Cyclophosphamide;Fludarabine;Cyclosporine A;Mycophenolate Mofetil
2 Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney Cancer Completed NCT00923845 Phase 2 Pentostatin;Sirolimus;Cyclophosphamide
3 Allogeneic Stem Cell Transplantationin Relapsed Hematological Malignancy: Early GVHD Prophylaxis Recruiting NCT02593123 Phase 2 mycophenolate mofetil
4 Stem Cell Transplant With or Without Tbo-filgrastim in Treating Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Recruiting NCT03317899 Phase 2 Tbo-filgrastim
5 ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma Recruiting NCT03441958 Phase 1, Phase 2
6 Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant Recruiting NCT02668315 Phase 1, Phase 2
7 Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant Recruiting NCT03330795 Phase 1, Phase 2
8 Renal Allograft Tolerance Through Mixed Chimerism Active, not recruiting NCT01780454 Phase 1, Phase 2 MEDI-507;Rituximab
9 Pilot Study Using Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in Hematopoietic Stem Cell Transplant Recipients Active, not recruiting NCT02420223 Phase 2 Propranolol
10 Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases Enrolling by invitation NCT01852370 Phase 1, Phase 2
11 BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance Terminated NCT02029638 Phase 2 Fludarabine;Low dose Pre-transplant cyclophosphamide;Acetaminophen;Diphenhydramine;Methylprednisolone;MESNA;Mycophenolate mofetil (MMF);Prednisone;Filgrastim;High dose post-transplant cyclophosphamide
12 Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation Recruiting NCT03483324 Phase 1
13 Engraftment Syndrome After Autologous Stem Cell Transplant: Retrospective Review in Patients With Multiple Myeloma Completed NCT01622582

Search NIH Clinical Center for Engraftment Syndrome

Genetic Tests for Engraftment Syndrome

Anatomical Context for Engraftment Syndrome

MalaCards organs/tissues related to Engraftment Syndrome:

41
Bone, Bone Marrow, Lung, Kidney, Neutrophil, T Cells, Skin

Publications for Engraftment Syndrome

Articles related to Engraftment Syndrome:

(show top 50) (show all 65)
# Title Authors Year
1
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. ( 29741437 )
2018
2
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. ( 29706650 )
2018
3
Case of engraftment syndrome appearing as scratch dermatitis. ( 28983967 )
2018
4
Procalcitonin and cytokine profiles in engraftment syndrome in pediatric stem cell transplantation. ( 27762068 )
2017
5
Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients. ( 28756243 )
2017
6
Evaluation of engraftment syndrome in children following full-matched related donor hematopoietic stem cell transplantations. ( 27103077 )
2016
7
Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients. ( 26740373 )
2016
8
Favorable outcome to glucocorticoid therapy for engraftment syndrome in pediatric autologous hematopoietic cell transplant. ( 26833703 )
2016
9
Dexamethasone palmitate for patients with engraftment syndrome is associated with favorable outcome for children with hematological malignancy. ( 27376452 )
2016
10
Pre-engraftment syndrome: clinical significance and pathophysiology. ( 27722122 )
2016
11
Engraftment syndrome manifesting as acute brachial neuropathy following high-dose chemotherapy for management of plasma cell myeloma. ( 27116896 )
2016
12
Infusion-related febrile reaction after haploidentical stem cell transplantation in children is associated with higher rates of engraftment syndrome and acute graft-versus-host disease. ( 26332180 )
2015
13
Engraftment syndrome, the Emperor's new clothes and the artist formerly known as prince. ( 25642762 )
2015
14
Engraftment syndrome: double-edged sword of hematopoietic cell transplants. ( 25581406 )
2015
15
Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach. ( 26327628 )
2015
16
Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. ( 26526424 )
2015
17
High incidence of engraftment syndrome after haploidentical allogeneic stem cell transplantation. ( 26152555 )
2015
18
Engraftment syndrome after allogeneic hematopoietic cell transplantation in adults. ( 24668776 )
2014
19
Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes. ( 24892262 )
2014
20
Engraftment syndrome in hematopoietic stem cell transplantations. ( 24867116 )
2014
21
Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. ( 23806770 )
2013
22
Pulmonary manifestations of the pre-engraftment syndrome after umbilical cord blood transplantation. ( 24346710 )
2013
23
Elafin: a possible new biomarker and immunohistochemical stain for pre-engraftment syndrome. ( 23866880 )
2013
24
Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. ( 23334274 )
2013
25
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. ( 23792270 )
2013
26
Peri-engraftment syndrome in allogeneic hematopoietic SCT. ( 23000648 )
2013
27
Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease. ( 23380345 )
2013
28
Histological features and immune cell changes in skin lesions of engraftment syndrome of children undergoing hematopoietic stem cell transplantation. ( 22207558 )
2012
29
Pre-engraftment syndrome after unrelated donor umbilical cord blood transplantation in patients with hematologic malignancies. ( 21933279 )
2012
30
Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. ( 22399264 )
2012
31
Post-autologous hematopoietic SCT engraftment syndrome: a single center experience. ( 21499317 )
2012
32
Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome. ( 20603623 )
2011
33
Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic SCT. ( 20383212 )
2011
34
Syngeneic donor hematopoietic stem cell transplantation is associated with high rates of engraftment syndrome. ( 20870027 )
2011
35
Engraftment syndrome after hematopoietic stem cell transplantation: high-resolution computed tomography findings in 2 patients. ( 21042224 )
2011
36
Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation. ( 21815185 )
2011
37
Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. ( 19857590 )
2010
38
Engraftment syndrome after auto-SCT: analysis of diagnostic criteria and risk factors in a large series from a single center. ( 20062097 )
2010
39
Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature. ( 20371446 )
2010
40
Colitis secondary to engraftment syndrome in a patient with autologous peripheral blood stem cell transplant. ( 19499337 )
2010
41
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. ( 19509133 )
2009
42
Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children. ( 19067915 )
2009
43
Incidence, predisposing factors, and outcome of engraftment syndrome in pediatric allogeneic stem cell transplant recipients. ( 18342786 )
2008
44
Peripheral blood stem cell transplant for POEMS syndrome is associated with high rates of engraftment syndrome. ( 18221391 )
2008
45
Pre-engraftment syndrome in hematopoietic stem cell transplantation. ( 18303207 )
2008
46
Bilateral marginal keratitis associated with engraftment syndrome after hematopoietic stem cell transplantation. ( 17592333 )
2007
47
Engraftment syndrome after hematopoietic stem cell transplantation in multiple myeloma. ( 17026829 )
2006
48
Engraftment syndrome after nonmyeloablative allogeneic hematopoietic stem cell transplantation: incidence and effects on survival. ( 15983554 )
2005
49
Steroids prevent engraftment syndrome after autologous hematopoietic stem cell transplantation without increasing the risk of infection. ( 15640827 )
2005
50
Engraftment syndrome after autologous peripheral blood progenitor cell transplantation in pediatric patients: a prospective evaluation of risk factors and outcome. ( 15516943 )
2004

Variations for Engraftment Syndrome

Expression for Engraftment Syndrome

Search GEO for disease gene expression data for Engraftment Syndrome.

Pathways for Engraftment Syndrome

Pathways related to Engraftment Syndrome according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.26 CSF2 CXCL8 IFNA1
2
Show member pathways
12.05 CSF2 CSF3 CXCL8 IFNA1
3
Show member pathways
11.99 CSF2 CSF3 CXCL8
4
Show member pathways
11.51 ABCB1 CYP3A5
5
Show member pathways
11.49 CSF2 CXCL8
6
Show member pathways
11.4 CSF2 CXCL8
7
Show member pathways
11.4 CSF2 CSF3 CXCL8
8
Show member pathways
11.38 ABCB1 CYP3A5
9
Show member pathways
11.33 ABCB1 CYP3A5
10
Show member pathways
11.32 ABCB1 CYP3A5
11 11.25 CSF3 CXCL8
12 11.23 CSF2 CSF3
13
Show member pathways
11.12 ABCB1 CYP3A5
14 11.04 CSF2 CXCL8
15 11.02 ABCB1 CYP3A5
16 10.97 CSF2 CSF3
17
Show member pathways
10.84 ABCB1 CYP3A5
18 10.82 CSF2 CSF3 CXCL8
19 10.72 CALCA CSF2 CSF3 CXCL8
20 10.61 ABCB1 CYP3A5
21 10.58 ABCB1 CYP3A5
22 10.48 ABCB1 CYP3A5
23 10.32 ABCB1 CYP3A5

GO Terms for Engraftment Syndrome

Cellular components related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CSF2 CSF3 CXCL8 IFNA1
2 extracellular region GO:0005576 9.1 CALCA CSF2 CSF3 CXCL8 IFNA1 PI3

Biological processes related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 CSF2 CSF3 CXCL8 IFNA1
2 cellular response to lipopolysaccharide GO:0071222 9.43 CSF2 CSF3 CXCL8
3 receptor internalization GO:0031623 9.32 CALCA CXCL8
4 regulation of signaling receptor activity GO:0010469 9.02 CALCA CSF2 CSF3 CXCL8 IFNA1
5 neutrophil differentiation GO:0030223 8.96 CSF2 CSF3

Molecular functions related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CSF2 CSF3 CXCL8 IFNA1

Sources for Engraftment Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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