MCID: ENG004
MIFTS: 26

Engraftment Syndrome

Categories: Rare diseases

Aliases & Classifications for Engraftment Syndrome

MalaCards integrated aliases for Engraftment Syndrome:

Name: Engraftment Syndrome 20 70

Classifications:



External Ids:

UMLS 70 C0919746

Summaries for Engraftment Syndrome

MalaCards based summary : Engraftment Syndrome is related to capillary leak syndrome and exanthem. An important gene associated with Engraftment Syndrome is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are JAK-STAT signaling pathway and IL-17 Family Signaling Pathways. Affiliated tissues include skin, bone marrow and endothelial.

Related Diseases for Engraftment Syndrome

Diseases related to Engraftment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 31.7 CXCL8 CSF2
2 exanthem 30.1 IFNA1 CXCL8 CSF3 CSF2
3 myeloma, multiple 29.9 CXCL8 CSF3 CSF2 ABCB1
4 bacterial infectious disease 29.5 CXCL8 CSF3 CSF2
5 testicular germ cell cancer 29.5 CYP3A5 CSF3 ABCB1
6 myelodysplastic syndrome 29.4 CXCL8 CSF3 CSF2 ABCB1
7 peripheral nervous system disease 29.2 CXCL8 CSF3 CSF2 CALCA
8 adult respiratory distress syndrome 29.2 PI3 CXCL8 CSF3 CALCA
9 hypereosinophilic syndrome 29.1 IFNA1 CXCL8 CSF2
10 diarrhea 29.1 IFNA1 CXCL8 CSF3 CALCA ABCB1
11 graft-versus-host disease 10.4
12 acute graft versus host disease 10.4
13 soft tissue sarcoma 10.2 CSF3 ABCB1
14 granulocytopenia 10.2 CSF3 CSF2
15 felty syndrome 10.2 CSF3 CSF2
16 pulmonary edema 10.2
17 mucormycosis 10.2 CSF3 CSF2
18 neutrophilia, hereditary 10.2 CSF3 CSF2
19 eosinophilic gastroenteritis 10.2 CSF3 CSF2
20 neutropenia, severe congenital, 3, autosomal recessive 10.2 CSF3 CSF2
21 hypersplenism 10.2 CSF3 CSF2
22 cellulitis 10.2 CSF3 CSF2
23 scabies 10.2 CXCL8 CSF3
24 metanephric adenoma 10.2 CXCL8 CSF3
25 neutrophilic dermatosis, acute febrile 10.1 CXCL8 CSF3
26 relapsing polychondritis 10.1 CXCL8 CSF3
27 vaginitis 10.1 CXCL8 ABCB1
28 acute chest syndrome 10.1 CXCL8 CSF3
29 sapho syndrome 10.1 CXCL8 CALCA
30 erysipelas 10.1 PI3 CALCA
31 impetigo 10.1 PI3 CALCA
32 burning mouth syndrome 10.1 CXCL8 CALCA
33 pyoderma 10.1 CXCL8 CSF3
34 acute monoblastic leukemia 10.1 CXCL8 CSF2
35 pyoderma gangrenosum 10.1 CXCL8 CSF3
36 fungal meningitis 10.1 CXCL8 CSF2
37 juvenile arthritis 10.1 CXCL8 CSF2
38 viral meningitis 10.1 CXCL8 CALCA
39 acute pyelonephritis 10.1 CXCL8 CALCA
40 drug-induced lupus erythematosus 10.1 CXCL8 CSF2
41 amyloidosis 10.1
42 invasive aspergillosis 10.1 CXCL8 CSF3
43 pasteurellosis 10.1 PI3 CXCL8
44 septic arthritis 10.1 CXCL8 CALCA
45 pharyngitis 10.1 CXCL8 CSF2
46 appendicitis 10.1 CXCL8 CSF3
47 eosinophilic pneumonia 10.0 CXCL8 CSF2
48 clopidogrel resistance 10.0 CYP3A5 ABCB1
49 complex regional pain syndrome 10.0 CXCL8 CALCA
50 erythema nodosum 10.0 CXCL8 CSF2

Graphical network of the top 20 diseases related to Engraftment Syndrome:



Diseases related to Engraftment Syndrome

Symptoms & Phenotypes for Engraftment Syndrome

Drugs & Therapeutics for Engraftment Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Engraftment Syndrome After Autologous Stem Cell Transplant: Retrospective Review in Patients With Multiple Myeloma Completed NCT01622582

Search NIH Clinical Center for Engraftment Syndrome

Genetic Tests for Engraftment Syndrome

Anatomical Context for Engraftment Syndrome

MalaCards organs/tissues related to Engraftment Syndrome:

40
Skin, Bone Marrow, Endothelial, Myeloid, Heart, T Cells, Neutrophil

Publications for Engraftment Syndrome

Articles related to Engraftment Syndrome:

(show top 50) (show all 163)
# Title Authors PMID Year
1
Successful treatment of EBV-related lymphoproliferative disease after heart transplantation with autologous hematopoietic stem cell transplantation despite transient heart failure associated with engraftment syndrome. 61
32766933 2021
2
Utility of novel T-cell-specific extracellular vesicles in monitoring and evaluation of acute GVHD. 61
33683652 2021
3
Kidney injury and disease in patients with haematological malignancies. 61
33785910 2021
4
Comparison of Total Body Irradiation-based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL. 61
33625092 2021
5
Prophylactic corticosteroid use prevents engraftment syndrome in patients after autologous stem cell transplantation. 61
32979278 2021
6
Evaluating the incidence of engraftment syndrome with different melphalan formulations in adult multiple myeloma and immunoglobulin light chain amyloidosis patients undergoing autologous hematopoietic cell transplantation. 61
33435822 2021
7
Intrapatient variability in concentration/dose ratio of tacrolimus predicts transplant-associated thrombotic microangiopathy. 61
32876853 2021
8
The induction strategies administered in the treatment of multiple myeloma exhibit a deleterious effect on the endothelium. 61
32404979 2020
9
Prior anti-PD-1 therapy as a risk factor for life-threatening peri-engraftment respiratory distress syndrome in patients undergoing autologous stem cell transplantation. 61
33273659 2020
10
Retrospective Evaluation of Relationship Between Iron Overload and Transplantation Complications in Pediatric Patient Who Underwent Allogeneic Stem Cell Transplantation Due to Acute Leukemia and Myelodysplastic Syndrome. 61
32427707 2020
11
Inducing Transient Mixed Chimerism for Allograft Survival Without Maintenance Immunosuppression With Combined Kidney and Bone Marrow Transplantation: Protocol Optimization. 61
31634324 2020
12
Engraftment Syndrome and Acute Graft-versus-Host Disease: A Meta-Analysis. 61
32524098 2020
13
Engraftment syndrome following hematopoietic stem cell transplant: A review of the literature. 61
32279341 2020
14
Toxoplasma-induced hemophagocytic lymphohistiocytosis after haploidentical allogeneic stem cell transplantation. 61
31895492 2020
15
Postautologous stem cell transplantation engraftment syndrome: Improved treatment and outcomes. 61
31997402 2020
16
The avoidance of G-CSF and the addition of prophylactic corticosteroids after autologous stem cell transplantation for multiple myeloma patients appeal for the at-home setting to reduce readmission for neutropenic fever. 61
33147257 2020
17
Outcome of Acute Respiratory Failure Secondary to Engraftment in Children After Hematopoietic Stem Cell Transplant. 61
33163412 2020
18
Chemotherapy-induced pulmonary complications in cancer: Significance of clinicoradiological correlation. 61
32476746 2020
19
Incidence and characteristics of engraftment syndrome after autologous hematopoietic cell transplantation in light chain amyloidosis. 61
31347424 2019
20
Acute kidney injury in hematopoietic stem cell transplantation. 61
31524721 2019
21
Increased fecal primary bile acids in multiple myeloma with engraftment syndrome diarrhea after stem cell transplant. 61
31148601 2019
22
Autologous Stem Cell Transplantation for Multiple Myeloma: Growth Factor Matters. 61
31173899 2019
23
POEMS Syndrome: Indian Experience From a Tertiary-Care Institute. 61
31262669 2019
24
Engraftment syndrome, transplant-associated thrombotic microangiopathy and hemophagocytic syndrome following autologous stem cell transplant in multiple myeloma. 61
31090118 2019
25
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. 61
31409584 2019
26
Erythema migrans spares rash of engraftment syndrome. 61
31268589 2019
27
Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies. 61
31097308 2019
28
Complications of Stem Cell Transplantation that Affect Infections in Stem Cell Transplant Recipients, with Analogies to Patients with Hematologic Malignancies. 61
30940464 2019
29
Development of Pre-Engraftment Syndrome, but Not Acute Graft-versus-Host Disease, Reduces Relapse Rate of Acute Myelogenous Leukemia after Single Cord Blood Transplantation. 61
30771495 2019
30
Effect of Timing and Complement Receptor Antagonism on Intragraft Recruitment and Protolerogenic Effects of Mesenchymal Stromal Cells in Murine Kidney Transplantation. 61
30801518 2019
31
Procalcitonin as a biomarker to differentiate bacterial infections from engraftment syndrome following autologous hematopoietic stem cell transplantation for multiple myeloma. 61
30549311 2019
32
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. 61
29741437 2019
33
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. 61
29706650 2018
34
[Efficacy Analysis of Unrelated Umbilical Cord Blood Transplantation for the Treatment of Wiskott-Aldrich Syndrome]. 61
30501726 2018
35
Late-onset fever and engraftment syndrome following autologous stem cell transplant: Impact on resource utilization. 61
30027614 2018
36
Pulmonary infectious complications after hematopoietic stem cell transplantation: a practical guide to clinicians. 61
29889152 2018
37
Engraftment Syndrome: Clinical Features and Predictive Factors in Autologous Stem Cell Transplant. 61
30127551 2018
38
Post-hematopoietic stem cell transplant hemophagocytic lymphohistiocytosis or an impostor: Case report and review of literature. 61
29577525 2018
39
Case of engraftment syndrome appearing as scratch dermatitis. 61
28983967 2018
40
Autologous Graft-Versus-Host Disease of the Gastrointestinal Tract in Patients With Multiple Myeloma and Hematopoietic Stem Cell Transplantation. 61
29511407 2018
41
Circulating endothelial cell count: a reliable marker of endothelial damage in patients undergoing hematopoietic stem cell transplantation. 61
28892085 2017
42
[A Case of Shock Due to nabPTX Administration Successfully Treated with Cytokine Adsorption Therapy]. 61
29394633 2017
43
Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients. 61
28756243 2017
44
Capillary leak syndrome: etiologies, pathophysiology, and management. 61
28318633 2017
45
Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. 61
28207973 2017
46
Viral encephalitis after haplo-identical hematopoietic stem cell transplantation: Causative viral spectrum, characteristics, and risk factors. 61
28129450 2017
47
Procalcitonin and cytokine profiles in engraftment syndrome in pediatric stem cell transplantation. 61
27762068 2017
48
Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions. 61
28111964 2017
49
Higher dose of CD34+ peripheral blood stem cells is associated with better survival after haploidentical stem cell transplantation in pediatric patients. 61
27888540 2017
50
Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis. 61
27643869 2017

Variations for Engraftment Syndrome

Expression for Engraftment Syndrome

Search GEO for disease gene expression data for Engraftment Syndrome.

Pathways for Engraftment Syndrome

Pathways related to Engraftment Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.07 IFNA1 CSF3 CSF2
2
Show member pathways
11.91 CXCL8 CSF3 CSF2
3
Show member pathways
11.35 CYP3A5 ABCB1
4
Show member pathways
11.3 CXCL8 CSF3 CSF2
5
Show member pathways
11.28 CYP3A5 ABCB1
6 11.26 CXCL8 CSF3
7 11.23 CSF3 CSF2
8 11.12 CYP3A5 ABCB1
9
Show member pathways
11.07 CYP3A5 ABCB1
10
Show member pathways
11.04 CYP3A5 ABCB1
11 11 CXCL8 CSF2
12 10.96 CYP3A5 ABCB1
13 10.9 CSF3 CSF2
14 10.82 CXCL8 CSF3 CSF2
15 10.72 CXCL8 CSF3 CSF2 CALCA
16 10.54 CYP3A5 ABCB1
17 10.5 CYP3A5 ABCB1
18 10.26 CYP3A5 ABCB1

GO Terms for Engraftment Syndrome

Cellular components related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 PI3 IFNA1 CXCL8 CSF3 CSF2 CALCA
2 extracellular space GO:0005615 9.1 PI3 IFNA1 CXCL8 CSF3 CSF2 CALCA

Biological processes related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor internalization GO:0031623 9.16 CXCL8 CALCA
2 cellular response to lipopolysaccharide GO:0071222 9.13 CXCL8 CSF3 CSF2
3 cytokine-mediated signaling pathway GO:0019221 8.92 IFNA1 CXCL8 CSF3 CSF2

Molecular functions related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNA1 CXCL8 CSF3 CSF2

Sources for Engraftment Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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