MCID: ENG004
MIFTS: 35

Engraftment Syndrome

Categories: Rare diseases

Aliases & Classifications for Engraftment Syndrome

MalaCards integrated aliases for Engraftment Syndrome:

Name: Engraftment Syndrome 54 74

Classifications:



External Ids:

UMLS 74 C0919746

Summaries for Engraftment Syndrome

MalaCards based summary : Engraftment Syndrome is related to capillary leak syndrome and bacterial infectious disease. An important gene associated with Engraftment Syndrome is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and IL-17 Family Signaling Pathways. The drugs Mycophenolic acid and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney.

Related Diseases for Engraftment Syndrome

Diseases related to Engraftment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 32.0 CSF2 CXCL8
2 bacterial infectious disease 29.6 CSF2 CSF3 CXCL8
3 leukemia, acute myeloid 29.4 ABCB1 CSF2 CSF3
4 myeloma, multiple 29.2 ABCB1 CSF2 CSF3 CXCL8 IFNA1
5 hematopoietic stem cell transplantation 10.3
6 trichosporonosis 10.2 CSF2 CSF3
7 granulocytopenia 10.2 CSF2 CSF3
8 acute monoblastic leukemia 10.2 CSF2 CXCL8
9 meconium aspiration syndrome 10.2 CSF2 CXCL8
10 anemia of prematurity 10.2 CSF2 CSF3
11 ecthyma 10.2 CSF2 CSF3
12 vaginitis 10.2 ABCB1 CXCL8
13 mastitis 10.2 CSF2 CXCL8
14 graft-versus-host disease 10.1
15 aseptic meningitis 10.1 CALCA CXCL8
16 leukocyte disease 10.1 CSF2 CSF3
17 bacterial sepsis 10.1 CALCA CXCL8
18 bacterial pneumonia 10.1 CALCA CXCL8
19 severe acute respiratory syndrome 10.1 CXCL8 IFNA1
20 bronchial disease 10.1 CSF2 CXCL8
21 pancytopenia 10.1 CSF2 CSF3
22 stomatitis 10.1 CSF2 CSF3
23 gastroenteritis 10.1 CXCL8 IFNA1
24 felty syndrome 10.0 CSF2 CSF3 CXCL8
25 cyclic neutropenia 10.0 CSF2 CSF3 CXCL8
26 monocytic leukemia 10.0 CSF2 CXCL8
27 clopidogrel resistance 10.0 ABCB1 CYP3A5
28 parathyroid adenoma 10.0 ABCB1 CALCA
29 acute graft versus host disease 10.0
30 mucositis 10.0 ABCB1 CSF2 CSF3
31 neutropenia 10.0 CSF2 CSF3 IFNA1
32 hematologic cancer 10.0 ABCB1 CSF2 CSF3
33 lymphoma, non-hodgkin, familial 10.0 ABCB1 CSF2 CSF3
34 severe congenital neutropenia 10.0 CSF2 CSF3
35 bone marrow cancer 10.0 CSF2 CSF3 IFNA1
36 poems syndrome 9.9
37 acute respiratory distress syndrome 9.9 CXCL8 PI3
38 kaposi sarcoma 9.9 CSF2 CXCL8 IFNA1
39 small cell cancer of the lung 9.9 ABCB1 CALCA CSF3
40 acquired immunodeficiency syndrome 9.9 CSF2 IFNA1
41 murray valley encephalitis 9.9 IFNA1 PI3
42 impetigo 9.9 CALCA PI3
43 extrinsic allergic alveolitis 9.9 CXCL8 PI3
44 erysipelas 9.9 CALCA PI3
45 acute lymphocytic leukemia 9.8 CSF2 CSF3
46 renal cell carcinoma, nonpapillary 9.8 ABCB1 CSF2 IFNA1
47 lung disease 9.7 CSF2 CXCL8 PI3
48 breast cancer 9.7
49 multiple sclerosis 9.7
50 myelodysplastic syndrome 9.7

Graphical network of the top 20 diseases related to Engraftment Syndrome:



Diseases related to Engraftment Syndrome

Symptoms & Phenotypes for Engraftment Syndrome

Drugs & Therapeutics for Engraftment Syndrome

Drugs for Engraftment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 3,Phase 2,Phase 1 24280-93-1 446541
2
Fludarabine Approved Phase 3,Phase 1,Phase 2 75607-67-9, 21679-14-1 30751
3
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
4
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
5
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
6
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
7
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
8
tannic acid Approved Phase 3 1401-55-4
9 Anti-Bacterial Agents Phase 3,Phase 2
10 Antineoplastic Agents, Alkylating Phase 3,Phase 2
11 Antiviral Agents Phase 3
12 Antimetabolites Phase 3,Phase 2
13 Anti-Infective Agents Phase 3,Phase 2
14 Immunosuppressive Agents Phase 3,Phase 2
15 Antimetabolites, Antineoplastic Phase 3,Phase 2
16 Immunologic Factors Phase 3,Phase 2,Phase 1
17 Vidarabine Phosphate Phase 3
18 Alkylating Agents Phase 3,Phase 2
19 Antibiotics, Antitubercular Phase 3,Phase 2
20 Antitubercular Agents Phase 3,Phase 2
21 Cyclosporins Phase 3,Phase 2
22 Antifungal Agents Phase 3,Phase 2
23 Dermatologic Agents Phase 3,Phase 2
24 Antirheumatic Agents Phase 3,Phase 2,Phase 1
25 Calcineurin Inhibitors Phase 3
26
Pentostatin Approved, Investigational Phase 2 53910-25-1 40926 439693
27
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
28
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
29
Adenosine Approved, Investigational Phase 2 58-61-7 60961
30
Lenograstim Approved, Investigational Phase 2 135968-09-1
31
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
32
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
33
Tacrolimus Approved, Investigational Phase 1, Phase 2,Phase 2 104987-11-3 445643 439492 6473866
34
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
35
Propranolol Approved, Investigational Phase 2 525-66-6 4946
36
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
37
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
38
Mesna Approved, Investigational Phase 2 3375-50-6 598
39
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
40
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
41
Acetaminophen Approved Phase 2 103-90-2 1983
42
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
43
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
44
Promethazine Approved, Investigational Phase 2 60-87-7 4927
45
Histamine Approved, Investigational Phase 2 51-45-6 774
46
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
47 Adjuvants, Immunologic Phase 2
48 Tin Fluorides Phase 2
49 Antineoplastic Agents, Immunological Phase 1, Phase 2
50 Antihypertensive Agents Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Single vs Double Umbilical Cord Blood Transplants in Children With High Risk Leukemia and Myelodysplasia (BMT CTN 0501) Completed NCT00412360 Phase 3 Cyclophosphamide;Fludarabine;Cyclosporine A;Mycophenolate Mofetil
2 Low-Intensity Stem Cell Transplantation With Multiple Lymphocyte Infusions to Treat Advanced Kidney Cancer Completed NCT00923845 Phase 2 Pentostatin;Sirolimus;Cyclophosphamide
3 Expanded Cord Blood in Patients in Need of an Allogeneic Stem Cell Transplant Completed NCT02668315 Phase 1, Phase 2
4 Allogeneic Stem Cell Transplantationin Relapsed Hematological Malignancy: Early GVHD Prophylaxis Recruiting NCT02593123 Phase 2 mycophenolate mofetil
5 Stem Cell Transplant With or Without Tbo-filgrastim in Treating Patients With Multiple Myeloma or Non-Hodgkin Lymphoma Recruiting NCT03317899 Phase 2 Tbo-filgrastim
6 ECT-001 (UM171) Expanded Cord Blood Transplant to Treat High-risk Multiple Myeloma Recruiting NCT03441958 Phase 1, Phase 2
7 Bilateral Orthotopic Lung Transplant - Bone Marrow Transplant Recruiting NCT03330795 Phase 1, Phase 2
8 Renal Allograft Tolerance Through Mixed Chimerism Active, not recruiting NCT01780454 Phase 1, Phase 2 MEDI-507;Rituximab
9 Tinostamustine Conditioning and Autologous Stem Cell Active, not recruiting NCT03687125 Phase 1, Phase 2 Treatment with TINOSTAMUSTINE
10 Pilot Study Using Propranolol to Decrease Gene Expression of Stress-Mediated Beta-Adrenergic Pathways in Hematopoietic Stem Cell Transplant Recipients Active, not recruiting NCT02420223 Phase 2 Propranolol
11 Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases Enrolling by invitation NCT01852370 Phase 1, Phase 2
12 BMT and High Dose Post-Transplant Cyclophosphamide for Chimerism Induction and Renal Allograft Tolerance Terminated NCT02029638 Phase 2 Fludarabine;Cyclophosphamide;acetaminophen;diphenhydramine;methylprednisolone;MESNA;mycophenolate mofetil;prednisone;filgrastim
13 Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation Recruiting NCT03483324 Phase 1
14 Engraftment Syndrome After Autologous Stem Cell Transplant: Retrospective Review in Patients With Multiple Myeloma Completed NCT01622582

Search NIH Clinical Center for Engraftment Syndrome

Genetic Tests for Engraftment Syndrome

Anatomical Context for Engraftment Syndrome

MalaCards organs/tissues related to Engraftment Syndrome:

42
Bone, Bone Marrow, Kidney, Skin, Breast, T Cells, Myeloid

Publications for Engraftment Syndrome

Articles related to Engraftment Syndrome:

(show top 50) (show all 69)
# Title Authors Year
1
Development of pre-engraftment syndrome, but not acute graft-versus-host disease, reduces relapse rate of acute myeloid leukemia after single cord blood transplantation. ( 30771495 )
2019
2
Procalcitonin as a biomarker to differentiate bacterial infections from engraftment syndrome following autologous hematopoietic stem cell transplantation for multiple myeloma. ( 30549311 )
2019
3
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. ( 29741437 )
2018
4
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. ( 29706650 )
2018
5
Case of engraftment syndrome appearing as scratch dermatitis. ( 28983967 )
2018
6
Late-onset fever and engraftment syndrome following autologous stem cell transplant: Impact on resource utilization. ( 30027614 )
2018
7
Engraftment Syndrome: Clinical Features and Predictive Factors in Autologous Stem Cell Transplant. ( 30127551 )
2018
8
Procalcitonin and cytokine profiles in engraftment syndrome in pediatric stem cell transplantation. ( 27762068 )
2017
9
Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients. ( 28756243 )
2017
10
Evaluation of engraftment syndrome in children following full-matched related donor hematopoietic stem cell transplantations. ( 27103077 )
2016
11
Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients. ( 26740373 )
2016
12
Favorable outcome to glucocorticoid therapy for engraftment syndrome in pediatric autologous hematopoietic cell transplant. ( 26833703 )
2016
13
Dexamethasone palmitate for patients with engraftment syndrome is associated with favorable outcome for children with hematological malignancy. ( 27376452 )
2016
14
Pre-engraftment syndrome: clinical significance and pathophysiology. ( 27722122 )
2016
15
Engraftment syndrome manifesting as acute brachial neuropathy following high-dose chemotherapy for management of plasma cell myeloma. ( 27116896 )
2016
16
Infusion-related febrile reaction after haploidentical stem cell transplantation in children is associated with higher rates of engraftment syndrome and acute graft-versus-host disease. ( 26332180 )
2015
17
Engraftment syndrome, the Emperor's new clothes and the artist formerly known as prince. ( 25642762 )
2015
18
Engraftment syndrome: double-edged sword of hematopoietic cell transplants. ( 25581406 )
2015
19
Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach. ( 26327628 )
2015
20
Graft-versus-host disease (GVHD) prophylaxis by using methotrexate decreases pre-engraftment syndrome and severe acute GVHD, and accelerates engraftment after cord blood transplantation. ( 26526424 )
2015
21
High incidence of engraftment syndrome after haploidentical allogeneic stem cell transplantation. ( 26152555 )
2015
22
Engraftment syndrome after allogeneic hematopoietic cell transplantation in adults. ( 24668776 )
2014
23
Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes. ( 24892262 )
2014
24
Engraftment syndrome in hematopoietic stem cell transplantations. ( 24867116 )
2014
25
Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma. ( 23806770 )
2013
26
Pulmonary manifestations of the pre-engraftment syndrome after umbilical cord blood transplantation. ( 24346710 )
2013
27
Elafin: a possible new biomarker and immunohistochemical stain for pre-engraftment syndrome. ( 23866880 )
2013
28
Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment. ( 23334274 )
2013
29
Low levels of interleukin-1 receptor antagonist (IL-1RA) predict engraftment syndrome after autologous stem cell transplantation in POEMS syndrome and other plasma cell neoplasms. ( 23792270 )
2013
30
Peri-engraftment syndrome in allogeneic hematopoietic SCT. ( 23000648 )
2013
31
Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease. ( 23380345 )
2013
32
Histological features and immune cell changes in skin lesions of engraftment syndrome of children undergoing hematopoietic stem cell transplantation. ( 22207558 )
2012
33
Pre-engraftment syndrome after unrelated donor umbilical cord blood transplantation in patients with hematologic malignancies. ( 21933279 )
2012
34
Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. ( 22399264 )
2012
35
Post-autologous hematopoietic SCT engraftment syndrome: a single center experience. ( 21499317 )
2012
36
Recombinant human soluble thrombomodulin counteracts capillary leakage associated with engraftment syndrome. ( 20603623 )
2011
37
Engraftment syndrome, but not acute GVHD, younger age, CYP3A5 or MDR1 polymorphisms, increases tacrolimus clearance in pediatric hematopoietic SCT. ( 20383212 )
2011
38
Syngeneic donor hematopoietic stem cell transplantation is associated with high rates of engraftment syndrome. ( 20870027 )
2011
39
Engraftment syndrome after hematopoietic stem cell transplantation: high-resolution computed tomography findings in 2 patients. ( 21042224 )
2011
40
Cyclophosphamide and prednisone induction followed by cyclophosphamide mobilization effectively decreases the incidence of engraftment syndrome in patients with POEMS syndrome who undergo stem cell transplantation. ( 21815185 )
2011
41
Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. ( 19857590 )
2010
42
Engraftment syndrome after auto-SCT: analysis of diagnostic criteria and risk factors in a large series from a single center. ( 20062097 )
2010
43
Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature. ( 20371446 )
2010
44
Colitis secondary to engraftment syndrome in a patient with autologous peripheral blood stem cell transplant. ( 19499337 )
2010
45
Rapid immune recovery and graft-versus-host disease-like engraftment syndrome following adoptive transfer of Costimulated autologous T cells. ( 19509133 )
2009
46
Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children. ( 19067915 )
2009
47
Incidence, predisposing factors, and outcome of engraftment syndrome in pediatric allogeneic stem cell transplant recipients. ( 18342786 )
2008
48
Peripheral blood stem cell transplant for POEMS syndrome is associated with high rates of engraftment syndrome. ( 18221391 )
2008
49
Pre-engraftment syndrome in hematopoietic stem cell transplantation. ( 18303207 )
2008
50
Bilateral marginal keratitis associated with engraftment syndrome after hematopoietic stem cell transplantation. ( 17592333 )
2007

Variations for Engraftment Syndrome

Expression for Engraftment Syndrome

Search GEO for disease gene expression data for Engraftment Syndrome.

Pathways for Engraftment Syndrome

Pathways related to Engraftment Syndrome according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.08 CSF2 CSF3 IFNA1
2
Show member pathways
11.99 CSF2 CSF3 CXCL8
3 11.53 CSF2 CXCL8
4
Show member pathways
11.49 ABCB1 CYP3A5
5
Show member pathways
11.48 CSF2 CXCL8
6
Show member pathways
11.44 ABCB1 CYP3A5
7
Show member pathways
11.39 ABCB1 CYP3A5
8
Show member pathways
11.38 CSF2 CXCL8
9
Show member pathways
11.32 ABCB1 CYP3A5
10
Show member pathways
11.3 CSF2 CSF3 CXCL8
11 11.25 CSF3 CXCL8
12 11.23 CSF2 CSF3
13 11.04 CSF2 CXCL8
14 11.02 ABCB1 CYP3A5
15 10.96 CSF2 CSF3
16
Show member pathways
10.84 ABCB1 CYP3A5
17 10.84 CSF2 CSF3 CXCL8
18 10.82 CSF2 CSF3 CXCL8
19 10.72 CALCA CSF2 CSF3 CXCL8
20 10.58 ABCB1 CYP3A5
21 10.54 ABCB1 CYP3A5
22 10.44 ABCB1 CYP3A5
23 10.26 ABCB1 CYP3A5

GO Terms for Engraftment Syndrome

Cellular components related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 CALCA CSF2 CSF3 CXCL8 IFNA1
2 extracellular region GO:0005576 9.1 CALCA CSF2 CSF3 CXCL8 IFNA1 PI3

Biological processes related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.33 CSF2 CSF3 CXCL8
2 receptor internalization GO:0031623 9.26 CALCA CXCL8
3 cytokine-mediated signaling pathway GO:0019221 9.26 CSF2 CSF3 CXCL8 IFNA1
4 regulation of signaling receptor activity GO:0010469 9.02 CALCA CSF2 CSF3 CXCL8 IFNA1

Molecular functions related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CSF2 CSF3 CXCL8 IFNA1

Sources for Engraftment Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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