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MCID: ENG004
MIFTS: 30

Engraftment Syndrome

Categories: Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Engraftment Syndrome

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MalaCards integrated aliases for Engraftment Syndrome:

Name: Engraftment Syndrome 52 71

Classifications:

MalaCards categories:
Global: Rare diseases
See all MalaCards categories (disease lists)


External Ids:

UMLS 71 C0919746
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Summaries for Engraftment Syndrome

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MalaCards based summary : Engraftment Syndrome is related to capillary leak syndrome and exanthem. An important gene associated with Engraftment Syndrome is CSF3 (Colony Stimulating Factor 3), and among its related pathways/superpathways are JAK-STAT signaling pathway and IL-17 Family Signaling Pathways. The drugs Fludarabine and Thiotepa have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and kidney.

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Related Diseases for Engraftment Syndrome

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Diseases related to Engraftment Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 32.5 CXCL8 CSF2
2 exanthem 29.7 IFNA1 CXCL8 CSF3 CSF2
3 adult respiratory distress syndrome 29.4 CXCL8 CSF3 CALCA
4 peripheral nervous system disease 29.4 CXCL8 CSF3 CALCA
5 myelodysplastic syndrome 29.1 CXCL8 CSF3 CSF2 ABCB1
6 thrombocytosis 29.0 IFNA1 CSF3 CSF2
7 hypereosinophilic syndrome 28.8 IFNA1 CXCL8 CSF2
8 bacterial infectious disease 28.8 PI3 CXCL8 CSF3 CSF2
9 myeloma, multiple 28.7 IFNA1 CXCL8 CSF3 CSF2 ABCB1
10 diarrhea 28.6 IFNA1 CXCL8 CSF3 CALCA ABCB1
11 graft-versus-host disease 10.3
12 acute graft versus host disease 10.3
13 soft tissue sarcoma 10.3 CSF3 ABCB1
14 large granular lymphocyte leukemia 10.3 CSF3 CSF2
15 neutropenia, severe congenital, 3, autosomal recessive 10.2 CSF3 CSF2
16 granulocytopenia 10.2 CSF3 CSF2
17 neutrophilia, hereditary 10.2 CSF3 CSF2
18 mucormycosis 10.2 CSF3 CSF2
19 eosinophilic gastroenteritis 10.2 CSF3 CSF2
20 capillary disease 10.2 CSF3 CSF2
21 hypersplenism 10.2 CSF3 CSF2
22 scabies 10.2 CXCL8 CSF3
23 relapsing polychondritis 10.2 CXCL8 CSF3
24 acute chest syndrome 10.1 CXCL8 CSF3
25 sapho syndrome 10.1 CXCL8 CALCA
26 vaginitis 10.1 CXCL8 ABCB1
27 pyoderma 10.1 CXCL8 CSF3
28 erysipelas 10.1 PI3 CALCA
29 pyoderma gangrenosum 10.1 CXCL8 CSF3
30 burning mouth syndrome 10.1 CXCL8 CALCA
31 pulmonary edema 10.1
32 impetigo 10.1 PI3 CALCA
33 acute monoblastic leukemia 10.1 CXCL8 CSF2
34 headache 10.1 CALCA ABCB1
35 juvenile arthritis 10.1 CXCL8 CSF2
36 clopidogrel resistance 10.1 CYP3A5 ABCB1
37 invasive aspergillosis 10.1 CXCL8 CSF3
38 viral meningitis 10.1 CXCL8 CALCA
39 septic arthritis 10.1 CXCL8 CALCA
40 pasteurellosis 10.0 PI3 CXCL8
41 pharyngitis 10.0 CXCL8 CSF2
42 eosinophilic pneumonia 10.0 CXCL8 CSF2
43 bacterial sepsis 10.0 CXCL8 CALCA
44 bronchopneumonia 10.0 PI3 CXCL8
45 complex regional pain syndrome 10.0 CXCL8 CALCA
46 sensory peripheral neuropathy 10.0 CSF3 CALCA ABCB1
47 pulmonary eosinophilia 10.0 CXCL8 CSF2
48 nasal cavity disease 10.0 CXCL8 CSF2
49 appendicitis 10.0 CXCL8 CSF3
50 gastric ulcer 10.0 CXCL8 CALCA

Graphical network of the top 20 diseases related to Engraftment Syndrome:



Diseases related to Engraftment Syndrome
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Symptoms & Phenotypes for Engraftment Syndrome

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Drugs & Therapeutics for Engraftment Syndrome

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Drugs for Engraftment Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
2
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
3
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
4
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492 6473866
5
Clotrimazole Approved, Vet_approved Phase 1, Phase 2 23593-75-1 2812
6
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
7
alemtuzumab Approved, Investigational Phase 1, Phase 2 216503-57-0
8
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
9
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
10 Immunoglobulins Phase 1, Phase 2
11 Antibodies Phase 1, Phase 2
12 Anti-Infective Agents Phase 1, Phase 2
13 Antibodies, Monoclonal Phase 1, Phase 2
14 Alkylating Agents Phase 1, Phase 2
15 Antifungal Agents Phase 1, Phase 2
16 Immunosuppressive Agents Phase 1, Phase 2
17 Anti-Bacterial Agents Phase 1, Phase 2
18 Immunologic Factors Phase 1, Phase 2
19 Antirheumatic Agents Phase 1, Phase 2
20 Antineoplastic Agents, Immunological Phase 1, Phase 2
21 Antibiotics, Antitubercular Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Open-label Study of ECT-001-expanded Cord Blood Transplantation in Patients With High-risk Acute Leukemia/Myelodysplasia Recruiting NCT03913026 Phase 2
2 High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease Recruiting NCT02629120 Phase 1, Phase 2 Campath;Busulfan IV;Sirolimus;cyclophosphamide
3 Engraftment Syndrome After Autologous Stem Cell Transplant: Retrospective Review in Patients With Multiple Myeloma Completed NCT01622582
4 Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage From Patients With Lung Infiltrates Recruiting NCT00077909

Search NIH Clinical Center for Engraftment Syndrome

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Genetic Tests for Engraftment Syndrome

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Anatomical Context for Engraftment Syndrome

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MalaCards organs/tissues related to Engraftment Syndrome:

40
Bone, Bone Marrow, Kidney, Lung, Endothelial, Breast, Skin
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Publications for Engraftment Syndrome

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Articles related to Engraftment Syndrome:

(show top 50) (show all 153)
# Title Authors PMID Year
1
Retrospective Evaluation of Relationship Between Iron Overload and Transplantation Complications in Pediatric Patient Who Underwent Allogeneic Stem Cell Transplantation Due to Acute Leukemia and Myelodysplastic Syndrome. 61
32427707 2020
2
Inducing Transient Mixed Chimerism for Allograft Survival Without Maintenance Immunosuppression With Combined Kidney and Bone Marrow Transplantation: Protocol Optimization. 61
31634324 2020
3
Engraftment Syndrome and Acute Graft-versus-Host Disease: A Meta-Analysis. 61
32524098 2020
4
Engraftment syndrome following hematopoietic stem cell transplant: A review of the literature. 61
32279341 2020
5
The induction strategies administered in the treatment of multiple myeloma exhibit a deleterious effect on the endothelium. 61
32404979 2020
6
Toxoplasma-induced hemophagocytic lymphohistiocytosis after haploidentical allogeneic stem cell transplantation. 61
31895492 2020
7
Postautologous stem cell transplantation engraftment syndrome: Improved treatment and outcomes. 61
31997402 2020
8
Chemotherapy-induced pulmonary complications in cancer: Significance of clinicoradiological correlation. 61
32476746 2020
9
Incidence and characteristics of engraftment syndrome after autologous hematopoietic cell transplantation in light chain amyloidosis. 61
31347424 2019
10
Acute kidney injury in hematopoietic stem cell transplantation. 61
31524721 2019
11
Increased fecal primary bile acids in multiple myeloma with engraftment syndrome diarrhea after stem cell transplant. 61
31148601 2019
12
Autologous Stem Cell Transplantation for Multiple Myeloma: Growth Factor Matters. 61
31173899 2019
13
POEMS Syndrome: Indian Experience From a Tertiary-Care Institute. 61
31262669 2019
14
Engraftment syndrome, transplant-associated thrombotic microangiopathy and hemophagocytic syndrome following autologous stem cell transplant in multiple myeloma. 61
31090118 2019
15
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. 61
31409584 2019
16
Erythema migrans spares rash of engraftment syndrome. 61
31268589 2019
17
Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies. 61
31097308 2019
18
Effect of Timing and Complement Receptor Antagonism on Intragraft Recruitment and Protolerogenic Effects of Mesenchymal Stromal Cells in Murine Kidney Transplantation. 61
30801518 2019
19
Complications of Stem Cell Transplantation that Affect Infections in Stem Cell Transplant Recipients, with Analogies to Patients with Hematologic Malignancies. 61
30940464 2019
20
Development of Pre-Engraftment Syndrome, but Not Acute Graft-versus-Host Disease, Reduces Relapse Rate of Acute Myelogenous Leukemia after Single Cord Blood Transplantation. 61
30771495 2019
21
Procalcitonin as a biomarker to differentiate bacterial infections from engraftment syndrome following autologous hematopoietic stem cell transplantation for multiple myeloma. 61
30549311 2019
22
Previous exposure to bortezomib is linked to a lower risk of engraftment syndrome after autologous hematopoietic stem cell transplantation. 61
29741437 2019
23
Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation. 61
29706650 2018
24
[Efficacy Analysis of Unrelated Umbilical Cord Blood Transplantation for the Treatment of Wiskott-Aldrich Syndrome]. 61
30501726 2018
25
Late-onset fever and engraftment syndrome following autologous stem cell transplant: Impact on resource utilization. 61
30027614 2018
26
Pulmonary infectious complications after hematopoietic stem cell transplantation: a practical guide to clinicians. 61
29889152 2018
27
Engraftment Syndrome: Clinical Features and Predictive Factors in Autologous Stem Cell Transplant. 61
30127551 2018
28
Post-hematopoietic stem cell transplant hemophagocytic lymphohistiocytosis or an impostor: Case report and review of literature. 61
29577525 2018
29
Autologous Graft-Versus-Host Disease of the Gastrointestinal Tract in Patients With Multiple Myeloma and Hematopoietic Stem Cell Transplantation. 61
29511407 2018
30
Case of engraftment syndrome appearing as scratch dermatitis. 61
28983967 2018
31
Circulating endothelial cell count: a reliable marker of endothelial damage in patients undergoing hematopoietic stem cell transplantation. 61
28892085 2017
32
[A Case of Shock Due to nabPTX Administration Successfully Treated with Cytokine Adsorption Therapy]. 61
29394633 2017
33
Cytokine Profiles of Pre-Engraftment Syndrome after Single-Unit Cord Blood Transplantation for Adult Patients. 61
28756243 2017
34
Capillary leak syndrome: etiologies, pathophysiology, and management. 61
28318633 2017
35
Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation. 61
28207973 2017
36
Viral encephalitis after haplo-identical hematopoietic stem cell transplantation: Causative viral spectrum, characteristics, and risk factors. 61
28129450 2017
37
Procalcitonin and cytokine profiles in engraftment syndrome in pediatric stem cell transplantation. 61
27762068 2017
38
Association between C-reactive protein levels in the first 1-3 days post-transplant and allogeneic immune reactions. 61
28111964 2017
39
Higher dose of CD34+ peripheral blood stem cells is associated with better survival after haploidentical stem cell transplantation in pediatric patients. 61
27888540 2017
40
Thrombomodulin blocks calcineurin inhibitor-induced vascular permeability via inhibition of Src/VE-cadherin axis. 61
27643869 2017
41
High-dose therapy and autologous stem cell transplantation in patients with POEMS syndrome: a retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancy Working Party of the European Society for Blood & Marrow Transplantation. 61
27634201 2017
42
Engraftment syndrome manifesting as acute brachial neuropathy following high-dose chemotherapy for management of plasma cell myeloma. 61
27116896 2016
43
Raiders of the lost mark - endothelial cells and their role in transplantation for hematologic malignancies. 61
27396981 2016
44
Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation. 61
27358215 2016
45
Dexamethasone palmitate for patients with engraftment syndrome is associated with favorable outcome for children with hematological malignancy. 61
27376452 2016
46
Pre-engraftment syndrome: clinical significance and pathophysiology. 61
27722122 2016
47
Umbilical cord blood transplantation for adults using tacrolimus with two-day very-short-term methotrexate for graft-versus-host disease prophylaxis. 61
27376545 2016
48
[Comparison of intensified myeloablative conditioning regime without antithymocytic globulin (ATG) with myeloablative conditioning regime for single-unit unrelated umbilical cord blood transplantation in hematological malignancies]. 61
27480651 2016
49
Epidemiology of Acute Respiratory Distress Syndrome Following Hematopoietic Stem Cell Transplantation. 61
26807683 2016
50
Evaluation of engraftment syndrome in children following full-matched related donor hematopoietic stem cell transplantations. 61
27103077 2016
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Variations for Engraftment Syndrome

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Expression for Engraftment Syndrome

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Search GEO for disease gene expression data for Engraftment Syndrome.
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Pathways for Engraftment Syndrome

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Pathways related to Engraftment Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
JAK-STAT signaling pathway 36
Show member pathways
 12.14 IFNA1 CSF3 CSF2
2
IL-17 Family Signaling Pathways 64
Show member pathways
 11.91 CXCL8 CSF3 CSF2
3
Irinotecan Pathway, Pharmacokinetics 60
Show member pathways
 11.35 CYP3A5 ABCB1
4
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.3 CXCL8 CSF3 CSF2
5
Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics 60
Show member pathways
 11.27 CYP3A5 ABCB1
6
Malaria 36
11.25 CXCL8 CSF3
7
Hematopoietic Stem Cell Differentiation 1
11.22 CSF3 CSF2
8
Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics 60
11.1 CYP3A5 ABCB1
9
Erlotinib Pathway, Pharmacokinetics 60
Show member pathways
 11.05 CYP3A5 ABCB1
10
Pazopanib Pathway, Pharmacokinetics 60
Show member pathways
 11.03 CYP3A5 ABCB1
11
Syndecan-2-mediated signaling events 1
11 CXCL8 CSF2
12
Constitutive Androstane Receptor Pathway 1
10.96 CYP3A5 ABCB1
13
Cytokines and Inflammatory Response 1
10.9 CSF3 CSF2
14
Interleukin-10 signaling 65
10.82 CXCL8 CSF3 CSF2
15
Lung fibrosis 1
10.72 CXCL8 CSF3 CSF2 CALCA
16
Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics 60
10.54 CYP3A5 ABCB1
17
Etoposide Pathway, Pharmacokinetics/Pharmacodynamics 60
10.5 CYP3A5 ABCB1
18
Vinka Alkaloid Pathway, Pharmacokinetics 60
10.26 CYP3A5 ABCB1
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GO Terms for Engraftment Syndrome

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Cellular components related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 PI3 IFNA1 CXCL8 CSF3 CSF2 CALCA
2 extracellular space GO:0005615 9.1 PI3 IFNA1 CXCL8 CSF3 CSF2 CALCA

Biological processes related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor internalization GO:0031623 9.16 CXCL8 CALCA
2 cellular response to lipopolysaccharide GO:0071222 9.13 CXCL8 CSF3 CSF2
3 cytokine-mediated signaling pathway GO:0019221 8.92 IFNA1 CXCL8 CSF3 CSF2

Molecular functions related to Engraftment Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNA1 CXCL8 CSF3 CSF2
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Sources for Engraftment Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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