MCID: ENP001
MIFTS: 30

Enophthalmos

Categories: Eye diseases

Aliases & Classifications for Enophthalmos

MalaCards integrated aliases for Enophthalmos:

Name: Enophthalmos 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11175
ICD10 33 H05.4 H05.40
ICD9CM 35 376.5 376.50
MeSH 44 D015841
NCIt 50 C79552
SNOMED-CT 68 80093006
UMLS 73 C0014306

Summaries for Enophthalmos

MalaCards based summary : Enophthalmos is related to esotropia and silent sinus syndrome. An important gene associated with Enophthalmos is TFAP2A (Transcription Factor AP-2 Alpha). The drugs Calcium, Dietary and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and breast, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Enophthalmos is the posterior displacement of the eyeball within the orbit due to changes in the volume... more...

Related Diseases for Enophthalmos

Graphical network of the top 20 diseases related to Enophthalmos:



Diseases related to Enophthalmos

Symptoms & Phenotypes for Enophthalmos

GenomeRNAi Phenotypes related to Enophthalmos according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.17 EPB41L1 TFAP2A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.17 TFAP2A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.17 TFAP2A
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.17 EPB41L1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.17 EPB41L1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.17 EPB41L1

Drugs & Therapeutics for Enophthalmos

Drugs for Enophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Calcium, Dietary Phase 2
2 Bone Density Conservation Agents Phase 2
3
Cocaine Approved, Illicit ,Not Applicable 50-36-2 5760 446220
4 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polycaprolactone / Tricalcium Phosphate (PCL/TCP) v Titanium Orbital Implant : Randomised Trial Unknown status NCT01119144 Phase 2
2 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
3 Use of a Low Profile Titanium Mesh in Orbital Reconstruction Completed NCT01432964
4 Resorbable Polymer Plates in Repair of Blowout Orbital Floor Fractures Active, not recruiting NCT03683615 Not Applicable
5 Efficiency of 3D-printed Implant Versus Autograft for Orbital Reconstruction (TOR-3D) Not yet recruiting NCT03608280 Not Applicable
6 The Use of 3D Printing in Orbital Fractures Not yet recruiting NCT03673865 Not Applicable

Search NIH Clinical Center for Enophthalmos

Cochrane evidence based reviews: enophthalmos

Genetic Tests for Enophthalmos

Anatomical Context for Enophthalmos

MalaCards organs/tissues related to Enophthalmos:

41
Eye, Bone, Breast, Brain

Publications for Enophthalmos

Articles related to Enophthalmos:

(show top 50) (show all 288)
# Title Authors Year
1
Resolution of Diplopia in Late Repair of Enophthalmos Following Facial Trauma. ( 29561480 )
2018
2
Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid. ( 29369151 )
2018
3
&amp;quot;Functional Outcomes of Late Post-Traumatic Enophthalmos Correction&amp;quot;. ( 29870508 )
2018
4
Isolated Medial Orbital Wall Fracture Associated with Enophthalmos in a Paediatric Patient: An Unusual Presentation. ( 29643794 )
2018
5
Correction of Delayed Traumatic Enophthalmos Using Customized Orbital Implants. ( 29654775 )
2018
6
Correlation between increased orbital volume and enophthalmos and diplopia in patients with fractures of the orbital floor or the medial orbital wall. ( 30041991 )
2018
7
Functional Outcomes of Late Posttraumatic Enophthalmos Correction. ( 30045183 )
2018
8
Enophthalmos and Orbital Volume Changes in Zygomaticomaxillary Complex Fractures: Is There a Correlation Between Them? ( 30267706 )
2018
9
Predictors of enophthalmos among adult patients with pure orbital blowout fractures. ( 30289909 )
2018
10
Localized scleroderma causing enophthalmos: A rare entity. ( 30355873 )
2018
11
3-Dimensional Volumetric Analysis of Relationship Between the Orbital Volume Ratio and Enophthalmos in Unoperated Blowout Fractures. ( 30399329 )
2018
12
Re: "Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid". ( 30418403 )
2018
13
Reply re: "Autologous Fat Graft (AFG) for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid". ( 30418404 )
2018
14
Comments on &amp;quot;A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line&amp;quot;. ( 28279685 )
2017
15
Development of late enophthalmos in pure blowout fractures: methodologic issues in prediction studies. ( 28983893 )
2017
16
Secondary Repair of Posttraumatic Enophthalmos and Extraocular Movement Disorders. ( 29195241 )
2017
17
Secondary Reconstruction of Posttraumatic Enophthalmos with Titanium Mesh and Buccal Fat Pad Graft: Case Report. ( 28825031 )
2017
18
Orbital Volume Augmentation with Calcium Hydroxyapatite Filler in Anophthalmic Enophthalmos. ( 29090049 )
2017
19
Isolated nonpulsatile enophthalmos in neurofibromatosis: An uncommon entity. ( 29044092 )
2017
20
Prediction of Late Enophthalmos Using Preoperative Orbital Volume and Fracture Area Measurements in Blowout Fracture. ( 28834836 )
2017
21
Differences in interpalpebral fissure measurement in patients with unilateral enophthalmos resulting from orbital wall fractures. ( 28344027 )
2017
22
A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line. ( 27542546 )
2016
23
Sliced Costochondral Chip Grafts in Posttraumatic Enophthalmos Correction. ( 28027179 )
2016
24
Secondary Reconstruction of Residual Enophthalmos Using an Endoscope and Considering the Orbital Floor and Medial Wall Slope. ( 27244206 )
2016
25
Can customized implants correct enophthalmos and delayed diplopia in post-traumatic orbital deformities? A volumetric analysis. ( 27157630 )
2016
26
The Correlation between the Orbital Volume Ratio and Enophthalmos in Unoperated Blowout Fractures. ( 27896181 )
2016
27
Prediction of the development of late enophthalmos in pure blowout fractures: delayed orbital tissue atrophy plays a major role. ( 27198642 )
2016
28
Linear scleroderma en coup de sabre presenting with positional diplopia and enophthalmos. ( 27754909 )
2016
29
Predicting late enophthalmos: Differences between medial and inferior orbital wall fractures. ( 27769606 )
2016
30
The imploding antrum: An unusual case of nontraumatic painless enophthalmos. ( 27905348 )
2016
31
Orbital Volume Augmentation for Enophthalmos Following Ventriculoperitoneal Shunting: A Case Study in &amp;quot;Silent Brain Syndrome&amp;quot;. ( 26866332 )
2016
32
Periorbital and Orbital Aging: Senile Enophthalmos as a Cause of Upper Eyelid Ptosis. ( 27348683 )
2016
33
Metastatic Scirrhous Breast Carcinoma to Orbit Causing Enophthalmos. ( 27342331 )
2016
34
Antral bony wall erosion, trigeminal nerve injury, and enophthalmos after root canal surgery. ( 27465790 )
2016
35
Enophthalmos and Hemifacial Skeletal Atrophy After Trigeminal Nerve Injury. ( 26784553 )
2016
36
Surgical correction of severe enophthalmos caused by bullet injury. ( 27723646 )
2016
37
Association of Titanium Mesh and Bovine Pericardium Membrane in the Treatment of Severe Enophthalmos. ( 26468837 )
2015
38
Acquired enophthalmos with systemic lupus erythematosus. ( 26306741 )
2015
39
Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. ( 25439599 )
2015
40
Correction of Late Posttraumatic Enophthalmos Using an Antral Balloon. ( 26080197 )
2015
41
Prostaglandin-Associated Enophthalmos: An Observer-Masked Radiological Study of Patients Treated with Prostaglandin Drops to One Eye Only. ( 26540119 )
2015
42
Hyaluronic Acid Gel Re-Injection for Enophthalmos Correction in Silent Sinus Syndrome. ( 26516690 )
2015
43
Retracting Globe: Enophthalmos and Retraction Due to an Accessory Extraocular Muscle. ( 25714085 )
2015
44
Posttraumatic Delayed Enophthalmos: Analogies with Silent Sinus Syndrome? Case Report and Literature Review. ( 26269736 )
2015
45
Pulsatile enophthalmos, severe esotropia, kinked optic nerve and visual loss in neurofibromatosis type-1. ( 26903735 )
2015
46
Silent sinus syndrome as a recognised cause of unilateral painless enophthalmos. ( 24859556 )
2014
47
Retroseptal lipotransfer to correct enophthalmos in the postraumatic amaurotic eye. ( 25415124 )
2014
48
Titanium screw entered into maxillary sinus: a rare incident during rigid fixation of the porous polyethylene implant in enophthalmos correction. ( 25006927 )
2014
49
The temporoparietal adipofascial flap for the correction of recurrent idiopathic enophthalmos. ( 24621720 )
2014
50
Correction of severe enophthalmos by simultaneous fat grafting and anatomic orbital reconstruction. ( 25203579 )
2014

Variations for Enophthalmos

Expression for Enophthalmos

Search GEO for disease gene expression data for Enophthalmos.

Pathways for Enophthalmos

GO Terms for Enophthalmos

Sources for Enophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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