MCID: ENP001
MIFTS: 30

Enophthalmos

Categories: Eye diseases

Aliases & Classifications for Enophthalmos

MalaCards integrated aliases for Enophthalmos:

Name: Enophthalmos 12 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11175
ICD9CM 36 376.5 376.50
MeSH 45 D015841
NCIt 51 C79552
SNOMED-CT 69 80093006
ICD10 34 H05.4 H05.40
UMLS 74 C0014306

Summaries for Enophthalmos

MalaCards based summary : Enophthalmos is related to silent sinus syndrome and horner's syndrome. An important gene associated with Enophthalmos is ERCC6 (ERCC Excision Repair 6, Chromatin Remodeling Factor). The drugs Calcium and Hormones have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Enophthalmos is the posterior displacement of the eyeball within the orbit due to changes in the volume... more...

Related Diseases for Enophthalmos

Diseases related to Enophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 silent sinus syndrome 11.5
2 horner's syndrome 11.4
3 fourth cranial nerve palsy, familial congenital 11.1
4 tetrasomy 9p 11.1
5 sinusitis 10.2
6 neurofibromatosis, type iv, of riccardi 10.2
7 systemic scleroderma 10.2
8 ptosis 10.1
9 maxillary sinusitis 10.1
10 lupus erythematosus 10.1
11 exophthalmos 10.1
12 orbital varix 10.1
13 breast cancer 10.0
14 neurofibromatosis, type i 10.0
15 hydrocephalus 10.0
16 chronic maxillary sinusitis 10.0
17 linear scleroderma 10.0
18 depression 10.0
19 blue rubber bleb nevus 9.9
20 duane retraction syndrome 1 9.9
21 systemic lupus erythematosus 9.9
22 retinoblastoma 9.9
23 strabismus 9.9
24 hallermann-streiff syndrome 9.9
25 aging 9.9
26 cataract 9.9
27 human venous malformation 9.9
28 lymphoma 9.9
29 monocular esotropia 9.9
30 entropion 9.9
31 tolosa-hunt syndrome 9.9
32 senile entropion 9.9
33 lagophthalmos 9.9
34 senile ectropion 9.9
35 ectropion 9.9
36 facial hemiatrophy 9.9
37 exostosis 9.9
38 retinitis 9.9
39 intracranial hypotension 9.9
40 movement disease 9.9
41 human immunodeficiency virus infectious disease 9.9
42 localized scleroderma 9.9
43 mechanical strabismus 9.9
44 neurofibroma 9.9
45 esotropia 9.9
46 orbit lymphoma 9.9
47 congenital hydrocephalus 9.9
48 degos 'en cocarde' erythrokeratoderma 9.9
49 orbital lymphoma 9.9
50 orbital disease 9.0 EPB41L1 FAF2 TFAP2A TNNI3K

Graphical network of the top 20 diseases related to Enophthalmos:



Diseases related to Enophthalmos

Symptoms & Phenotypes for Enophthalmos

GenomeRNAi Phenotypes related to Enophthalmos according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.1 EPB41L1 TFAP2A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.1 TFAP2A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.1 EPB41L1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.1 EPB41L1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.1 EPB41L1

Drugs & Therapeutics for Enophthalmos

Drugs for Enophthalmos (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
2 Hormones Phase 2
3 Bone Density Conservation Agents Phase 2
4 Calcium, Dietary Phase 2
5
Cocaine Approved, Illicit ,Not Applicable 50-36-2 446220 5760
6 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polycaprolactone / Tricalcium Phosphate (PCL/TCP) v Titanium Orbital Implant : Randomised Trial Unknown status NCT01119144 Phase 2
2 Reconstruction of the Orbit With a Bioresorbable Polycaprolactone Implant Completed NCT00233922 Phase 2
3 Use of a Low Profile Titanium Mesh in Orbital Reconstruction Completed NCT01432964
4 Resorbable Polymer Plates in Repair of Blowout Orbital Floor Fractures Active, not recruiting NCT03683615 Not Applicable
5 Efficiency of 3D-printed Implant Versus Autograft for Orbital Reconstruction (TOR-3D) Not yet recruiting NCT03608280 Not Applicable
6 Orbital Fractures Registry Not yet recruiting NCT03887988
7 The Use of 3D Printing in Orbital Fractures Not yet recruiting NCT03673865 Not Applicable

Search NIH Clinical Center for Enophthalmos

Cochrane evidence based reviews: enophthalmos

Genetic Tests for Enophthalmos

Anatomical Context for Enophthalmos

MalaCards organs/tissues related to Enophthalmos:

42
Eye, Bone, Brain

Publications for Enophthalmos

Articles related to Enophthalmos:

(show top 50) (show all 291)
# Title Authors Year
1
Enophthalmos and Orbital Volume Changes in Zygomaticomaxillary Complex Fractures: Is There a Correlation Between Them? ( 30267706 )
2019
2
Does Orbital Volume Change Using the Mirror Technique Have a Correlation With Posttraumatic Enophthalmos? ( 30817515 )
2019
3
Decreased orbital fat and enophthalmos due to bimatoprost: Quantitative analysis using magnetic resonance imaging. ( 30917168 )
2019
4
The Degree of Post-traumatic Enophthalmos Detectable by Lay Observers. ( 31100769 )
2019
5
Development of late enophthalmos in pure blowout fractures: methodologic issues in prediction studies. ( 28983893 )
2018
6
Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid. ( 29369151 )
2018
7
Resolution of Diplopia in Late Repair of Enophthalmos Following Facial Trauma. ( 29561480 )
2018
8
Isolated Medial Orbital Wall Fracture Associated with Enophthalmos in a Paediatric Patient: An Unusual Presentation. ( 29643794 )
2018
9
Correction of Delayed Traumatic Enophthalmos Using Customized Orbital Implants. ( 29654775 )
2018
10
"Functional Outcomes of Late Post-Traumatic Enophthalmos Correction". ( 29870508 )
2018
11
Correlation between increased orbital volume and enophthalmos and diplopia in patients with fractures of the orbital floor or the medial orbital wall. ( 30041991 )
2018
12
Functional Outcomes of Late Posttraumatic Enophthalmos Correction. ( 30045183 )
2018
13
Predictors of enophthalmos among adult patients with pure orbital blowout fractures. ( 30289909 )
2018
14
Localized scleroderma causing enophthalmos: A rare entity. ( 30355873 )
2018
15
3-Dimensional Volumetric Analysis of Relationship Between the Orbital Volume Ratio and Enophthalmos in Unoperated Blowout Fractures. ( 30399329 )
2018
16
Re: "Autologous Fat Graft for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid". ( 30418403 )
2018
17
Reply re: "Autologous Fat Graft (AFG) for the Treatment of Sighted Posttraumatic Enophthalmos and Sunken Upper Eyelid". ( 30418404 )
2018
18
Enophthalmos and Hemifacial Skeletal Atrophy After Trigeminal Nerve Injury. ( 26784553 )
2017
19
Orbital Volume Augmentation for Enophthalmos Following Ventriculoperitoneal Shunting: A Case Study in "Silent Brain Syndrome". ( 26866332 )
2017
20
Prediction of the development of late enophthalmos in pure blowout fractures: delayed orbital tissue atrophy plays a major role. ( 27198642 )
2017
21
Sliced Costochondral Chip Grafts in Posttraumatic Enophthalmos Correction. ( 28027179 )
2017
22
Comments on "A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line". ( 28279685 )
2017
23
Differences in interpalpebral fissure measurement in patients with unilateral enophthalmos resulting from orbital wall fractures. ( 28344027 )
2017
24
Secondary Reconstruction of Posttraumatic Enophthalmos with Titanium Mesh and Buccal Fat Pad Graft: Case Report. ( 28825031 )
2017
25
Prediction of Late Enophthalmos Using Preoperative Orbital Volume and Fracture Area Measurements in Blowout Fracture. ( 28834836 )
2017
26
Isolated nonpulsatile enophthalmos in neurofibromatosis: An uncommon entity. ( 29044092 )
2017
27
Orbital Volume Augmentation with Calcium Hydroxyapatite Filler in Anophthalmic Enophthalmos. ( 29090049 )
2017
28
Secondary Repair of Posttraumatic Enophthalmos and Extraocular Movement Disorders. ( 29195241 )
2017
29
Acquired enophthalmos with systemic lupus erythematosus. ( 26306741 )
2016
30
Can customized implants correct enophthalmos and delayed diplopia in post-traumatic orbital deformities? A volumetric analysis. ( 27157630 )
2016
31
Secondary Reconstruction of Residual Enophthalmos Using an Endoscope and Considering the Orbital Floor and Medial Wall Slope. ( 27244206 )
2016
32
Metastatic Scirrhous Breast Carcinoma to Orbit Causing Enophthalmos. ( 27342331 )
2016
33
Periorbital and Orbital Aging: Senile Enophthalmos as a Cause of Upper Eyelid Ptosis. ( 27348683 )
2016
34
Antral bony wall erosion, trigeminal nerve injury, and enophthalmos after root canal surgery. ( 27465790 )
2016
35
A Straightforward Method of Predicting Enophthalmos in Blowout Fractures Using Enophthalmos Estimate Line. ( 27542546 )
2016
36
Surgical correction of severe enophthalmos caused by bullet injury. ( 27723646 )
2016
37
Linear scleroderma en coup de sabre presenting with positional diplopia and enophthalmos. ( 27754909 )
2016
38
Predicting late enophthalmos: Differences between medial and inferior orbital wall fractures. ( 27769606 )
2016
39
The Correlation between the Orbital Volume Ratio and Enophthalmos in Unoperated Blowout Fractures. ( 27896181 )
2016
40
The imploding antrum: An unusual case of nontraumatic painless enophthalmos. ( 27905348 )
2016
41
Enophthalmos and choroidal atrophy after intraophthalmic artery chemotherapy for retinoblastoma. ( 25439599 )
2015
42
Retracting globe: enophthalmos and retraction due to an accessory extraocular muscle. ( 25714085 )
2015
43
Correction of Late Posttraumatic Enophthalmos Using an Antral Balloon. ( 26080197 )
2015
44
Posttraumatic Delayed Enophthalmos: Analogies with Silent Sinus Syndrome? Case Report and Literature Review. ( 26269736 )
2015
45
Association of Titanium Mesh and Bovine Pericardium Membrane in the Treatment of Severe Enophthalmos. ( 26468837 )
2015
46
Hyaluronic Acid Gel Re-Injection for Enophthalmos Correction in Silent Sinus Syndrome. ( 26516690 )
2015
47
Prostaglandin-Associated Enophthalmos: An Observer-Masked Radiological Study of Patients Treated with Prostaglandin Drops to One Eye Only. ( 26540119 )
2015
48
Pulsatile enophthalmos, severe esotropia, kinked optic nerve and visual loss in neurofibromatosis type-1. ( 26903735 )
2015
49
The temporoparietal adipofascial flap for the correction of recurrent idiopathic enophthalmos. ( 24621720 )
2014
50
Silent sinus syndrome as a recognised cause of unilateral painless enophthalmos. ( 24859556 )
2014

Variations for Enophthalmos

Expression for Enophthalmos

Search GEO for disease gene expression data for Enophthalmos.

Pathways for Enophthalmos

GO Terms for Enophthalmos

Molecular functions related to Enophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 8.62 ERCC6 TNNI3K

Sources for Enophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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