MCID: ENT003
MIFTS: 40

Enterobiasis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Enterobiasis

MalaCards integrated aliases for Enterobiasis:

Name: Enterobiasis 12 77 45 15 17 74
Oxyuriasis 12 45 74
Pinworm Infection 12 3
Enterobius Vermicularis Infection 12
Oxyuris Vermicularis Infection 12
Threadworm Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7457
SNOMED-CT 69 19722001
ICD10 34 B80

Summaries for Enterobiasis

CDC : 3 Image: Left: Adult male of E. vermicularis from a formalin-ethyl acetate (FEA) concentrated stool smear. The worm measured 1.4 mm in length. Image courtesy of Centre for Tropical Medicine and Imported Infectious Diseases. Right: Image of the eggs of the human parasite Enterobius vermicularis, or “human pinworm, ” captured on cellulose tape under significant magnification. Credit: DPDx, PHIL.

MalaCards based summary : Enterobiasis, also known as oxyuriasis, is related to strongyloidiasis and ascaris lumbricoides infection, and has symptoms including fever and pruritus. An important gene associated with Enterobiasis is ANGPTL6 (Angiopoietin Like 6), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Presenilin-Mediated Signaling. The drugs Mebendazole and Piperazine have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and ovary, and related phenotypes are mortality/aging and neoplasm

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching.

Wikipedia : 77 Pinworm infection, also known as enterobiasis, is a human parasitic disease caused by the pinworm. The... more...

Related Diseases for Enterobiasis

Diseases related to Enterobiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 strongyloidiasis 11.5
2 ascaris lumbricoides infection 10.4
3 ascaridiasis 10.4
4 appendicitis 10.3
5 arthritis 10.2
6 ileocolitis 10.2
7 endometritis 10.2
8 vaginal discharge 10.2
9 reactive arthritis 10.2
10 peritonitis 10.2
11 myoclonic-atonic epilepsy 10.1
12 trichuriasis 10.1
13 intestinal obstruction 10.1
14 trichinosis 10.0
15 suppressor of tumorigenicity 3 10.0
16 neutrophilic dermatosis, acute febrile 10.0
17 malaria 10.0
18 crohn's disease 10.0
19 arrhythmogenic right ventricular cardiomyopathy 10.0
20 taeniasis 10.0
21 giardiasis 10.0
22 acute cystitis 10.0
23 disease of mental health 10.0
24 post-traumatic stress disorder 10.0
25 endometriosis 10.0
26 in situ carcinoma 10.0
27 hypereosinophilic syndrome 10.0
28 ankylostomiasis 10.0

Graphical network of the top 20 diseases related to Enterobiasis:



Diseases related to Enterobiasis

Symptoms & Phenotypes for Enterobiasis

UMLS symptoms related to Enterobiasis:


fever, pruritus

MGI Mouse Phenotypes related to Enterobiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.35 ANGPTL6 APC MAF RBPJ SLC11A1
2 neoplasm MP:0002006 8.8 APC RBPJ SLC11A1

Drugs & Therapeutics for Enterobiasis

Drugs for Enterobiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mebendazole Approved, Vet_approved Phase 3 31431-39-7 4030
2
Piperazine Approved, Vet_approved Phase 3 110-85-0 4837
3
Sodium Citrate Approved, Investigational Phase 3 68-04-2
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
5 Antimitotic Agents Phase 3
6 Anthelmintics Phase 3
7 DMP 777 Phase 3 157341-41-8
8 Antiparasitic Agents Phase 3
9 Anti-Infective Agents Phase 3
10 Citrate Phase 3
11 Piperazine citrate Phase 3
12
Lithium carbonate Approved 554-13-2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Safety Study of Mebendazole in Children 2 to 10 Years of Age Completed NCT01173562 Phase 3 Mebendazole
2 Enterobius Vermicularis and Bruxism in Children Completed NCT03833505
3 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Enterobiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: enterobiasis

Genetic Tests for Enterobiasis

Anatomical Context for Enterobiasis

MalaCards organs/tissues related to Enterobiasis:

42
Colon, Kidney, Ovary, Neutrophil

Publications for Enterobiasis

Articles related to Enterobiasis:

(show top 50) (show all 196)
# Title Authors Year
1
Sweet syndrome in association with enterobiasis. ( 30187540 )
2019
2
Extraintestinal Oxyuriasis. ( 29807567 )
2018
3
A case of enterobiasis presenting as post-traumatic-stress-disorder (PTSD): a curious case of the infection with predominant mental health symptoms, presenting for the first time in the settings of a refugee camp. ( 28819532 )
2017
4
Incidental diagnosis of oxyuriasis through a colonoscopy. ( 27077026 )
2016
5
Enterobiasis: threadworm infection presenting as acute appendicitis in a 13-year-old girl. ( 25589531 )
2015
6
Fulminant variant of Loeffler disease mimicking arrhythmogenic right ventricular cardiomyopathy in the course of enterobiasis. ( 25246480 )
2014
7
Enterobiasis-related inflammatory caecal polyp masquerading as a malignancy. ( 24429050 )
2014
8
Effect of a one-off educational session about enterobiasis on knowledge, preventative practices, and infection rates among schoolchildren in South Korea. ( 25372146 )
2014
9
Enterobiasis of anterior rectal wall mimicking a tumour-like lesion. ( 25470874 )
2014
10
Enterobiasis and strongyloidiasis and associated co-infections and morbidity markers in infants, preschool- and school-aged children from rural coastal Tanzania: a cross-sectional study. ( 25486986 )
2014
11
Extraintestinal oxyuriasis - report of three cases and review of literature. ( 25186597 )
2014
12
Epidemiology of ascariasis, enterobiasis and giardiasis in a Romanian western county (Timis), 1993-2006. ( 23092688 )
2013
13
Environmental factors related to enterobiasis in a southeast region of Korea. ( 23468007 )
2013
14
Prevalence of enterobiasis among primary school children in Ragama, Sri Lanka. ( 24081170 )
2013
15
Fatal case of ectopic enterobiasis: Enterobius vermicularis in the kidneys. ( 21879805 )
2012
16
Impact of health education on the prevalence of enterobiasis in Korean preschool students. ( 22172595 )
2012
17
Peritoneal enterobiasis causing endometriosis-like symptoms. ( 23157050 )
2012
18
The post-treatment effects of enterobiasis on the occurrence of enuresis among children in Calabar, Nigeria. ( 21771477 )
2011
19
Geographical aspects of enterobiasis in Estonia. ( 19926328 )
2010
20
Parents' knowledge about enterobiasis might be one of the most important risk factors for enterobiasis in children. ( 20585527 )
2010
21
Education and imaging. Gastrointestinal: enterobiasis. ( 19196402 )
2009
22
Effectiveness of repeated examination to diagnose enterobiasis in nursery school groups. ( 19724696 )
2009
23
Enterobiasis in ectopic locations mimicking tumor-like lesions. ( 20016678 )
2009
24
Case-based estimation of the risk of enterobiasis. ( 18502624 )
2008
25
Enterobiasis: a neglected infection in adults. ( 18564704 )
2008
26
Enterobiasis among preschool children: a study from Kayseri, Turkey. ( 19050361 )
2008
27
Association between previous enterobiasis and current wheezing: evaluation of 1018 children. ( 17479601 )
2007
28
Distribution of enterobiasis among nursery school children in SE Estonia and of other helminthiases in Estonia. ( 16752158 )
2006
29
Impact of health educational programmes on the prevalence of enterobiasis in schoolchildren in Thailand. ( 15831115 )
2005
30
Enterobiasis and its relationship with anal itching and enuresis among school-age children in Calabar, Nigeria. ( 16156975 )
2005
31
Assessment of frequency, transmission, and genitourinary complications of enterobiasis (pinworms). ( 16207185 )
2005
32
Very high prevalence of enterobiasis among the hilltribal children in rural district "Mae Suk," Thailand. ( 15266232 )
2004
33
Enterobiasis mimicking Crohn's disease. ( 15333976 )
2004
34
Perineal nodule due to enterobiasis: an aspiration cytologic diagnosis. ( 12508185 )
2003
35
Prevalence and risk factors for enterobiasis among preschool children in a metropolitan city in Korea. ( 12884012 )
2003
36
Malaria and enterobiasis among Karen Long-neck tribe in Mae Hong Son Province. ( 19230567 )
2003
37
Oxyuriasis-induced intestinal obstruction in a child--case report. ( 14737955 )
2003
38
A case of ovarian enterobiasis. ( 12325444 )
2002
39
First evidence of enterobiasis in ancient Egypt. ( 12435149 )
2002
40
Enterobiasis in primary schools in Bang Khun Thian District, Bangkok, Thailand. ( 12971479 )
2002
41
Chemotherapy of enterobiasis (oxyuriasis). ( 11336585 )
2001
42
The prevalence of enterobiasis in children attending mobile health clinic of Huachiew Chalermprakiet University. ( 12041578 )
2001
43
Epidemiology and control of enterobiasis in a developmental center. ( 10832422 )
2000
44
Prevalence of enterobiasis and its incidence after blanket chemotherapy in a male orphanage. ( 11023083 )
2000
45
Progressive eosinophilia and elevated IgE in enterobiasis. ( 10435486 )
1999
46
Human enterobiasis in evolution: origin, specificity and transmission. ( 10511967 )
1999
47
Review of enterobiasis in Taiwan and offshore islands. ( 10496160 )
1998
48
Chemotherapeutic trial to control enterobiasis in schoolchildren. ( 9446908 )
1997
49
A longitudinal study of enterobiasis in three day care centers of Havana City. ( 9071032 )
1996
50
Ileal and colonic ulceration due to enterobiasis. ( 7472913 )
1995

Variations for Enterobiasis

Expression for Enterobiasis

Search GEO for disease gene expression data for Enterobiasis.

Pathways for Enterobiasis

Pathways related to Enterobiasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.52 APC RBPJ
2 11.31 APC RBPJ
3 10.62 APC RBPJ
4 10.29 MAF RBPJ

GO Terms for Enterobiasis

Biological processes related to Enterobiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 8.8 MAF RBPJ SLC11A1

Molecular functions related to Enterobiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.62 MAF RBPJ

Sources for Enterobiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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