MCID: ENT003
MIFTS: 49

Enterobiasis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Enterobiasis

MalaCards integrated aliases for Enterobiasis:

Name: Enterobiasis 12 76 44 15 73
Oxyuriasis 12 44 73
Pinworm Infection 12 3
Enterobius Vermicularis Infection 12
Oxyuris Vermicularis Infection 12
Threadworm Infection 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7457
ICD10 33 B80
SNOMED-CT 68 19722001

Summaries for Enterobiasis

CDC : 3 Pinworm infection is caused by a small, thin, white roundworm called Enterobius vermicularis. Although pinworom infection can affect all people, it most commonly occurs among children, institutionalized persons, and household members of persons with pinworm infection. Pinworm infection is treatable with over-the-counter or prescription medication, but reinfection, which occurs easily, should be prevented.

MalaCards based summary : Enterobiasis, also known as oxyuriasis, is related to strongyloidiasis and hypereosinophilic syndrome, and has symptoms including fever and pruritus. An important gene associated with Enterobiasis is ANGPTL6 (Angiopoietin Like 6), and among its related pathways/superpathways are Akt Signaling and Allograft rejection. The drugs Piperazine and Mebendazole have been mentioned in the context of this disorder. Affiliated tissues include colon, kidney and ovary, and related phenotypes are growth/size/body region and hematopoietic system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching.

Wikipedia : 76 Pinworm infection, also known as enterobiasis, is a human parasitic disease caused by the pinworm. The... more...

Related Diseases for Enterobiasis

Diseases related to Enterobiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 strongyloidiasis 32.3 IL13 IL5
2 hypereosinophilic syndrome 30.4 IL13 IL4 IL5
3 trichuriasis 30.4 IL13 IL9
4 trichinosis 30.3 IL4 IL5 IL9
5 malaria 29.3 CD163 IL13 IL17A IL4 IL5 IL9
6 appendicitis 10.2
7 jak3-deficient severe combined immunodeficiency 10.2 IL4 IL9
8 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL13 IL5
9 penicillin allergy 10.2 IL13 IL4
10 respiratory syncytial virus infectious disease 10.2 IL13 IL5
11 cough variant asthma 10.2 IL4 IL5
12 scleritis 10.2 IL4 IL5
13 paragonimiasis 10.2 IL13 IL5
14 egg allergy 10.2 IL4 IL5
15 arthritis 10.2
16 ileocolitis 10.2
17 endometritis 10.2
18 vaginal discharge 10.2
19 reactive arthritis 10.2
20 epididymitis 10.2
21 cytokine deficiency 10.2 IL13 IL5 IL9
22 sulfamethoxazole allergy 10.2 IL4 IL5
23 central nervous system sarcoma 10.2 CD163 CD68
24 atopic keratoconjunctivitis 10.2 IL4 IL5
25 campylobacteriosis 10.2 SLC11A1 TLR4
26 virus associated hemophagocytic syndrome 10.1 CD68 IL4
27 gaucher disease, type ii 10.1 IL4 IL5
28 brucellosis 10.1 IL4 SLC11A1 TLR4
29 nickel allergic contact dermatitis 10.1 IL13 IL4 IL5
30 adult xanthogranuloma 10.1 CD163 CD68
31 angiostrongyliasis 10.1 IL13 IL4 IL5
32 inflammatory bowel disease 4 10.1 IL13 IL4 IL5
33 apple allergy 10.1 IL13 IL4 IL5
34 latex allergy 10.1 IL13 IL4 IL5
35 eosinophilic meningitis 10.1 IL13 IL4 IL5
36 lymphoplasmacyte-rich meningioma 10.1 CD163 CD68
37 intestinal schistosomiasis 10.1 IL13 IL4 IL5
38 schistosomiasis 10.1 IL13 IL4 IL5
39 chronic tic disorder 10.1 IL13 IL4 IL5
40 chronic conjunctivitis 10.1 IL13 IL4 IL5
41 conjunctivitis 10.1 IL13 IL4 IL5
42 eosinophilic gastritis 10.1 IL13 IL4 IL5
43 bacterial infectious disease 10.1 IL17A SLC11A1 TLR4
44 vernal keratoconjunctivitis 10.1 IL13 IL4 IL5
45 keratoconjunctivitis 10.1 IL13 IL4 IL5
46 parasitic ichthyosporea infectious disease 10.1 CD68 IL4
47 urinary schistosomiasis 10.1 IL13 IL4 IL5
48 spleen cancer 10.1 CD163 CD68
49 conjunctival disease 10.1 IL13 IL4 IL5
50 pulmonary eosinophilia 10.1 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Enterobiasis:



Diseases related to Enterobiasis

Symptoms & Phenotypes for Enterobiasis

UMLS symptoms related to Enterobiasis:


fever, pruritus

MGI Mouse Phenotypes related to Enterobiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.21 ANGPTL6 IL13 IL17A IL4 IL5 MAF
2 hematopoietic system MP:0005397 10.18 CD163 CD68 IL13 IL17A IL4 IL5
3 homeostasis/metabolism MP:0005376 10.18 ANGPTL6 CD163 IL13 IL17A IL4 IL5
4 immune system MP:0005387 10.17 CD163 CD68 IL13 IL17A IL4 IL5
5 digestive/alimentary MP:0005381 10.16 IL13 IL17A IL4 IL5 IL9 NOS2
6 mortality/aging MP:0010768 10.03 ANGPTL6 IL13 IL17A IL4 MAF MCU
7 muscle MP:0005369 9.7 CD163 IL13 MCU NOS2 RBPJ TLR4
8 neoplasm MP:0002006 9.43 IL5 NOS2 RBPJ SLC11A1 TLR4 TRIM33
9 respiratory system MP:0005388 9.28 CD163 IL13 IL17A IL4 IL5 MCU

Drugs & Therapeutics for Enterobiasis

Drugs for Enterobiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Piperazine Approved, Vet_approved Phase 3 110-85-0 4837
2
Mebendazole Approved, Vet_approved Phase 3 31431-39-7 4030
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
4 Piperazine citrate Phase 3
5 Citrate Phase 3
6 Anti-Infective Agents Phase 3
7 Antiparasitic Agents Phase 3
8 Antimitotic Agents Phase 3
9 Anthelmintics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Safety Study of Mebendazole in Children 2 to 10 Years of Age Completed NCT01173562 Phase 3 Mebendazole
2 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Enterobiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: enterobiasis

Genetic Tests for Enterobiasis

Anatomical Context for Enterobiasis

MalaCards organs/tissues related to Enterobiasis:

41
Colon, Kidney, Ovary, Skin, Spleen, Neutrophil

Publications for Enterobiasis

Articles related to Enterobiasis:

(show top 50) (show all 194)
# Title Authors Year
1
Sweet syndrome in association with enterobiasis. ( 30187540 )
2018
2
Extraintestinal Oxyuriasis. ( 29807567 )
2018
3
A case of enterobiasis presenting as post-traumatic-stress-disorder (PTSD): a curious case of the infection with predominant mental health symptoms, presenting for the first time in the settings of a refugee camp. ( 28819532 )
2017
4
Incidental diagnosis of oxyuriasis through a colonoscopy. ( 27077026 )
2016
5
Enterobiasis: threadworm infection presenting as acute appendicitis in a 13-year-old girl. ( 25589531 )
2015
6
Fulminant variant of Loeffler disease mimicking arrhythmogenic right ventricular cardiomyopathy in the course of enterobiasis. ( 25246480 )
2014
7
Enterobiasis of anterior rectal wall mimicking a tumour-like lesion. ( 25508501 )
2014
8
Enterobiasis of anterior rectal wall mimicking a tumour-like lesion. ( 25470874 )
2014
9
Enterobiasis-related inflammatory caecal polyp masquerading as a malignancy. ( 24429050 )
2014
10
Effect of a One-Off Educational Session about Enterobiasis on Knowledge, Preventative Practices, and Infection Rates among Schoolchildren in South Korea. ( 25372146 )
2014
11
Enterobiasis and strongyloidiasis and associated co-infections and morbidity markers in infants, preschool- and school-aged children from rural coastal Tanzania: a cross-sectional study. ( 25486986 )
2014
12
Extraintestinal oxyuriasis - report of three cases and review of literature. ( 25186597 )
2014
13
Prevalence of enterobiasis among primary school children in Ragama, Sri Lanka. ( 24081170 )
2013
14
Epidemiology of ascariasis, enterobiasis and giardiasis in a Romanian western county (Timis), 1993-2006. ( 23092688 )
2013
15
Environmental factors related to enterobiasis in a southeast region of Korea. ( 23468007 )
2013
16
Impact of health education on the prevalence of enterobiasis in Korean preschool students. ( 22172595 )
2012
17
Fatal case of ectopic enterobiasis: Enterobius vermicularis in the kidneys. ( 21879805 )
2012
18
Peritoneal enterobiasis causing endometriosis-like symptoms. ( 23157050 )
2012
19
The post-treatment effects of enterobiasis on the occurrence of enuresis among children in Calabar, Nigeria. ( 21771477 )
2011
20
Geographical aspects of enterobiasis in Estonia. ( 19926328 )
2010
21
Parents' knowledge about enterobiasis might be one of the most important risk factors for enterobiasis in children. ( 20585527 )
2010
22
Enterobiasis in ectopic locations mimicking tumor-like lesions. ( 20016678 )
2009
23
Education and imaging. Gastrointestinal: enterobiasis. ( 19196402 )
2009
24
Effectiveness of repeated examination to diagnose enterobiasis in nursery school groups. ( 19724696 )
2009
25
Enterobiasis among preschool children: a study from Kayseri, Turkey. ( 19050361 )
2008
26
Case-based estimation of the risk of enterobiasis. ( 18502624 )
2008
27
Enterobiasis: a neglected infection in adults. ( 18564704 )
2008
28
Association between previous enterobiasis and current wheezing: evaluation of 1018 children. ( 17479601 )
2007
29
Distribution of enterobiasis among nursery school children in SE Estonia and of other helminthiases in Estonia. ( 16752158 )
2006
30
Impact of health educational programmes on the prevalence of enterobiasis in schoolchildren in Thailand. ( 15831115 )
2005
31
Assessment of frequency, transmission, and genitourinary complications of enterobiasis (pinworms). ( 16207185 )
2005
32
Enterobiasis and its relationship with anal itching and enuresis among school-age children in Calabar, Nigeria. ( 16156975 )
2005
33
Enterobiasis mimicking Crohn's disease. ( 15333976 )
2004
34
Very high prevalence of enterobiasis among the hilltribal children in rural district "Mae Suk," Thailand. ( 15266232 )
2004
35
Perineal nodule due to enterobiasis: an aspiration cytologic diagnosis. ( 12508185 )
2003
36
Prevalence and risk factors for enterobiasis among preschool children in a metropolitan city in Korea. ( 12884012 )
2003
37
Malaria and enterobiasis among Karen Long-neck tribe in Mae Hong Son Province. ( 19230567 )
2003
38
Oxyuriasis-induced intestinal obstruction in a child--case report. ( 14737955 )
2003
39
Enterobiasis in primary schools in Bang Khun Thian District, Bangkok, Thailand. ( 12971479 )
2002
40
A case of ovarian enterobiasis. ( 12325444 )
2002
41
First evidence of enterobiasis in ancient Egypt. ( 12435149 )
2002
42
The prevalence of enterobiasis in children attending mobile health clinic of Huachiew Chalermprakiet University. ( 12041578 )
2001
43
Chemotherapy of enterobiasis (oxyuriasis). ( 11336585 )
2001
44
Prevalence of enterobiasis and its incidence after blanket chemotherapy in a male orphanage. ( 11023083 )
2000
45
Epidemiology and control of enterobiasis in a developmental center. ( 10832422 )
2000
46
Progressive eosinophilia and elevated IgE in enterobiasis. ( 10435486 )
1999
47
Human enterobiasis in evolution: origin, specificity and transmission. ( 10511967 )
1999
48
Review of enterobiasis in Taiwan and offshore islands. ( 10496160 )
1998
49
Chemotherapeutic trial to control enterobiasis in schoolchildren. ( 9446908 )
1997
50
A longitudinal study of enterobiasis in three day care centers of Havana City. ( 9071032 )
1996

Variations for Enterobiasis

Expression for Enterobiasis

Search GEO for disease gene expression data for Enterobiasis.

Pathways for Enterobiasis

Pathways related to Enterobiasis according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 ANGPTL6 IL13 IL17A IL4 IL5 IL9
2
Show member pathways
12.75 IL13 IL17A IL4 IL5 IL9
3 12.71 IL13 IL4 IL5 NOS2 XIAP
4
Show member pathways
12.4 IL13 IL17A IL4 IL5 MAF RBPJ
5
Show member pathways
12.31 IL17A IL4 IL5 IL9
6
Show member pathways
12.27 IL13 IL4 IL5 IL9
7
Show member pathways
12.2 IL13 IL17A IL4 IL5
8
Show member pathways
12.12 IL4 NOS2 TLR4 XIAP
9
Show member pathways
12.12 ANGPTL6 IL13 IL17A IL4 IL5 IL9
10
Show member pathways
11.96 ANGPTL6 IL13 IL17A IL4 IL5 IL9
11
Show member pathways
11.9 IL13 IL4 TLR4
12
Show member pathways
11.89 IL13 IL5 TLR4
13 11.88 CD163 CD68 IL4 IL5
14 11.87 IL4 NOS2 TLR4
15 11.85 IL13 IL17A IL4 NOS2
16 11.67 IL13 IL4 IL5
17
Show member pathways
11.63 IL4 IL5 MAF
18 11.56 IL13 IL17A IL4 IL5 IL9
19 11.53 IL13 IL4 IL5
20 11.28 CD163 CD68 IL13 IL17A IL4 NOS2
21 11.12 IL13 IL4 IL5
22 11.09 IL13 IL17A IL4 IL5 IL9
23 11.08 IL13 IL4 IL5 IL9
24 11.06 IL13 IL17A IL4 IL5 IL9
25 10.9 ANGPTL6 IL13 IL17A IL4 IL5 IL9
26 10.76 IL13 IL4 IL5 IL9 MAF RBPJ

GO Terms for Enterobiasis

Cellular components related to Enterobiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD163 IL13 IL17A TLR4

Biological processes related to Enterobiasis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 IL13 IL17A IL4 IL5 IL9
2 defense response to bacterium GO:0042742 9.81 NOS2 RBPJ SLC11A1 TLR4
3 regulation of cell proliferation GO:0042127 9.73 NOS2 RBPJ TCFL5 XIAP
4 positive regulation of gene expression GO:0010628 9.73 IL13 IL4 MAF RBPJ SLC11A1 TLR4
5 cytokine-mediated signaling pathway GO:0019221 9.72 IL13 IL17A IL4 IL5 NOS2
6 response to bacterium GO:0009617 9.71 NOS2 SLC11A1 TLR4
7 response to lipopolysaccharide GO:0032496 9.71 IL13 NOS2 SLC11A1 TLR4
8 defense response to Gram-negative bacterium GO:0050829 9.7 NOS2 SLC11A1 TLR4
9 immune response GO:0006955 9.7 IL13 IL17A IL4 IL5 IL9 SLC11A1
10 myeloid dendritic cell differentiation GO:0043011 9.57 IL4 RBPJ
11 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.56 IL17A TLR4
12 positive regulation of macrophage activation GO:0043032 9.55 IL13 TLR4
13 macrophage activation GO:0042116 9.49 SLC11A1 TLR4
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IL4 TLR4
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
16 positive regulation of B cell proliferation GO:0030890 9.26 IL13 IL4 IL5 TLR4
17 inflammatory response GO:0006954 9.17 CD163 IL13 IL17A IL5 IL9 SLC11A1
18 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 IL17A IL4 MAF RBPJ SLC11A1 TLR4

Molecular functions related to Enterobiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.13 IL13 IL4 IL9
2 cytokine activity GO:0005125 9.02 IL13 IL17A IL4 IL5 IL9

Sources for Enterobiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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