MCID: ENT001
MIFTS: 45

Enterocele

Categories: Gastrointestinal diseases, Reproductive diseases

Aliases & Classifications for Enterocele

MalaCards integrated aliases for Enterocele:

Name: Enterocele 12 15
Vaginal Enterocele 12
Hernias 63
Hernia 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1283
ICD9CM 35 618.6
MeSH 44 D006547
SNOMED-CT 68 47671001
UMLS 73 C0205792

Summaries for Enterocele

PubMed Health : 63 About hernias: Most hernias occur when part of the intestine or peritoneum pushes through a gap in the abdominal wall. The peritoneum is the membrane that lines the abdominal cavity and (completely or partly) encloses most of the organs in the abdomen. The protruding pouch, called the hernia sac or hernial sac, may contain part of the peritoneum, intestine or stomach, as well as belly fat. A bulge can usually be seen from the outside. Whether or not a hernia causes problems will depend on where it is and how big it is.These are the most common types of hernias:

MalaCards based summary : Enterocele, also known as vaginal enterocele, is related to syringomyelia and diaphragmatic hernia, congenital. An important gene associated with Enterocele is BRD2 (Bromodomain Containing 2), and among its related pathways/superpathways are G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Cefuroxime and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and lung, and related phenotypes are Decreased HIV-LTR-beta-galactosidase protein expression and cardiovascular system

Disease Ontology : 12 A prolapse of female genital organ that is characterized by the descent of a peritoneal sac containing small bowel into the rectovagnial space causing a bulge in the posterior vaginal wall.

Wikipedia : 76 An enterocele or enterocoele is a protrusion of the small intestines and peritoneum into the vaginal... more...

Related Diseases for Enterocele

Diseases related to Enterocele via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 727)
# Related Disease Score Top Affiliating Genes
1 syringomyelia 29.5 COL1A1 PVR
2 diaphragmatic hernia, congenital 12.7
3 hernia, hiatus 12.6
4 inguinal hernia 12.6
5 umbilical hernia 12.5
6 diaphragmatic hernia 3 12.4
7 omphalocele, diaphragmatic hernia, and radial ray defects 12.2
8 arthrogryposis multiplex with deafness, inguinal hernias, and early death 12.1
9 hernia of ovary and fallopian tube 12.1
10 diaphragmatic hernia 2 12.0
11 acromegaloid features, overgrowth, cleft palate, and hernia 12.0
12 microspherophakia with hernia 12.0
13 dandy-walker malformation with nasopharyngeal teratoma and diaphragmatic hernia 12.0
14 hernia, double inguinal 11.9
15 diverticulosis of bowel, hernia, and retinal detachment 11.9
16 epidermolysis bullosa with diaphragmatic hernia 11.9
17 sucrosuria, hiatus hernia and mental retardation 11.9
18 hernia, anterior diaphragmatic 11.9
19 diaphragmatic hernia exomphalos corpus callosum agenesis 11.9
20 diaphragmatic hernia upper limb defects 11.9
21 hydrocephaly corpus callosum agenesis diaphragmatic hernia 11.9
22 spigelian hernia-cryptorchidism syndrome 11.9
23 marfanoid habitus-inguinal hernia-advanced bone age syndrome 11.9
24 lethal hydranencephaly-diaphragmatic hernia syndrome 11.9
25 fryns syndrome 11.9
26 donnai-barrow syndrome 11.9
27 microphthalmia, syndromic 9 11.9
28 shprintzen-goldberg craniosynostosis syndrome 11.8
29 short syndrome 11.8
30 abdominal wall defect 11.7
31 galloway-mowat syndrome 11.7
32 microphthalmia, syndromic 12 11.7
33 smith-kingsmore syndrome 11.7
34 persistent mullerian duct syndrome 11.7
35 lambert syndrome 11.6
36 gastrocutaneous syndrome 11.6
37 pagod syndrome 11.6
38 galloway-mowat syndrome 1 11.6
39 tonne-kalscheuer syndrome 11.5
40 displacement of cardia through esophageal hiatus 11.5
41 spondylocostal dysostosis 3, autosomal recessive 11.3
42 chromosome 15q24 deletion syndrome 11.3
43 gas bloat syndrome 11.3
44 hydrocele 11.3
45 persistent mullerian duct syndrome, types i and ii 11.2
46 saal bulas syndrome 11.2
47 pseudomyxoma peritonei 11.2
48 mucopolysaccharidosis, type ii 11.1
49 simpson-golabi-behmel syndrome 11.1
50 hyperekplexia 11.1

Graphical network of the top 20 diseases related to Enterocele:



Diseases related to Enterocele

Symptoms & Phenotypes for Enterocele

GenomeRNAi Phenotypes related to Enterocele according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HIV-LTR-beta-galactosidase protein expression GR00224-A-1 8.8 CMKLR1 F2 MMP13

MGI Mouse Phenotypes related to Enterocele:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 ARHGEF1 BRD2 COL1A1 F2 IDUA MMP13
2 hematopoietic system MP:0005397 9.56 ARHGEF1 BRD2 CD9 CMKLR1 COL1A1 F2
3 immune system MP:0005387 9.23 ARHGEF1 BRD2 CD9 CMKLR1 COL1A1 F2

Drugs & Therapeutics for Enterocele

PubMedHealth treatment related to Enterocele: 63

Surgery is the only treatment option for hernias. It involves pushing the hernia sac back into the abdomen or removing it, and closing the gap in the abdominal wall with stitches. A fine synthetic mesh is usually placed on the affected area too, to strengthen the abdominal wall and prevent the hernia from coming back.In open surgery, the operation is carried out through a larger cut where the hernia is. In minimally invasive surgery (also called laparoscopic or keyhole surgery), several smaller cuts are made. The abdomen or abdominal wall are operated on by inserting surgical instruments and a fine tube with a camera attached to it (laparoscope) through the cuts. The camera enables the surgeon to see the inside of the abdomen on a monitor. The surgery options will depend on things like the type and size of the hernia.Hernias don’t always have to be operated on. If they aren’t causing any problems and the risk of complications is low, surgery isn’t necessary. This is also true in people who are very old, weak or seriously ill and have a hernia that doesn’t pose an acute risk.Hernia supports or hernia belts – tight, belt-like bandages – were often used in the past to try to stop hernias from bulging out of the abdomen. This is discouraged nowadays, though, because they don’t make the hernia go away and can have side effects such as pressure ulcers (bedsores).

Drugs for Enterocele (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefuroxime Approved Not Applicable 55268-75-2 5361202 5479529
2 tannic acid Approved Not Applicable
3
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
4 Anti-Infective Agents Not Applicable
5 Antibiotics, Antitubercular Not Applicable
6 cefuroxime axetil Not Applicable
7 Anti-Bacterial Agents Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
2 Prophylactic Antibiotic Treatment During Vaginal Repair Unknown status NCT00162604 Not Applicable Cefuroxime
3 Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy Unknown status NCT01289314 Not Applicable
4 Clinical Performance of the GYNECARE PROLIFT + M* Pelvic Floor Repair System as a Device for Pelvic Organ Prolapse Completed NCT00833001
5 Evaluation of the Avaulta Procedure for the Correction of Pelvic Organ Prolapse - Results at 1 Year Completed NCT00774215
6 Obstructed Defaecation: Proctography Versus Ultrasound in Symptomatic Patients Completed NCT02239302
7 Normal Values in Ano-rectal 3D High Resolution Manometry Completed NCT01710579 Not Applicable
8 Observational Data Collection of Surgical Outcomes in the Treatment of Vaginal Prolapse With AMS Products Completed NCT00388947
9 Treatment for Stress and Mixed Urinary Incontinence and Vaginal Vault Prolapse Completed NCT00223106 Not Applicable
10 SCP vs HUSLS for Pelvic Organ Prolapse Repair Recruiting NCT02800512 Not Applicable
11 Laser Therapy in Managing Vaginal Prolapse Recruiting NCT03714607 Not Applicable
12 Dynamic Magnetic Resonance Imaging Before and After Vaginal Prolapse Repair Recruiting NCT03315715
13 Sacrocolpopexy Versus Vaginal Mesh Procedure for Pelvic Prolapse Active, not recruiting NCT01097200 Not Applicable
14 Restorelle® Mesh Versus Native Tissue Repair for Prolapse Active, not recruiting NCT02162615
15 Anterior Versus Posterior Laparoscopic Mesh Rectopexy For Rectal Prolapse; a Randomized Controlled Trial. Not yet recruiting NCT03026738 Not Applicable
16 Exair® Versus Native Tissue Repair for Prolapse Terminated NCT02162628

Search NIH Clinical Center for Enterocele

Cochrane evidence based reviews: hernia

Genetic Tests for Enterocele

Anatomical Context for Enterocele

MalaCards organs/tissues related to Enterocele:

41
Small Intestine, Colon, Lung, Kidney, Liver, Heart, Prostate

Publications for Enterocele

Articles related to Enterocele:

(show top 50) (show all 137)
# Title Authors Year
1
Transvaginal native-tissue repair of enterocele. ( 29934767 )
2018
2
Intraoperative check for enterocele in perineal stapled prolapse resection. ( 29766343 )
2018
3
Enterocele Reduction in the Prone Position: New Horizons for Safer Stapled Transanal Rectal Resections. ( 30500977 )
2018
4
Temporary successful results of ventral rectopexy for enterocele surgical correction, about 138 patients. ( 28803377 )
2017
5
Rectal axis and enterocele on proctogram may predict laparoscopic ventral mesh rectopexy outcomes for rectal intussusception. ( 28674947 )
2017
6
Robot-assisted versus laparoscopic ventral rectopexy for external, internal rectal prolapse and enterocele: a randomised controlled trial. ( 26919191 )
2016
7
The Manchester-Fothergill and the Elevate PosteriorAr technique for the correction of a cervical elongation and large enterocele in a patient with bladder exstrophy and multiple surgeries. ( 25578871 )
2015
8
Urogynecological prolapse and enterocele are predictive of poor functional outcome after failed or complicated STARR procedures. ( 24691768 )
2014
9
Laparoscopic repair of recurrent lateral enterocele and rectocele. ( 25224146 )
2014
10
Aggressive angiomyxoma of rectovaginal septum, mimicking a huge recto-enterocele: a rare case report. ( 24757344 )
2014
11
[Enterocele containing cecum and terminal ileum at labium majus level]. ( 24094927 )
2013
12
Entero-colpo-defecography vs supine entero-MRI: which one is the best tool in the differentiation of enterocele, elytrocele and edrocele? ( 24152850 )
2013
13
The TRAM dam design: a new method for treatment of an enterocele. ( 22124762 )
2012
14
Enterocele is not a contraindication to stapled transanal surgery for outlet obstruction: an analysis of 170 patients. ( 21564465 )
2011
15
Symptomatic vaginal enterocele associated with malfunctioning ventriculoperitoneal shunt and cerebrospinal ascites. ( 21487828 )
2011
16
Small bowel incarceration associated with posthysterectomy enterocele. ( 19855912 )
2010
17
Role of enterocele in the obstructed defecation syndrome (ODS): a new radiological point of view. ( 19788492 )
2010
18
Rare cause of intestinal obstruction - Vaginal enterocele. ( 23133218 )
2010
19
Laparoscopic correction of enterocele associated to stapled transanal rectal resection for obstructed defecation syndrome. ( 19921222 )
2010
20
Transvaginal pelvic organ prolapse repair of anterior enterocele following cystectomy in females. ( 19089305 )
2009
21
Enterocele--diagnosis and treatment. ( 19200673 )
2009
22
Symptomatic enterocele. An unusual presentation of chylous ascites and lymphoma. ( 18239020 )
2008
23
A comparison of dynamic transperineal ultrasound (DTP-US) with dynamic evacuation proctography (DEP) in the diagnosis of cul de sac hernia (enterocele) in patients with evacuatory dysfunction. ( 18256847 )
2008
24
Rectal prolapse, rectal intussusception, rectocele, solitary rectal ulcer syndrome, and enterocele. ( 18794001 )
2008
25
Enterocele repair by abdominal obliteration of the pelvic inlet: long-term outcome on obstructed defaecation and symptoms of pelvic discomfort. ( 17608820 )
2007
26
Obliteration of the pelvic inlet by prophylene mesh and omentoplasty for enterocele. ( 16969606 )
2006
27
Laparoscopic vaginal vault suspension and enterocele repair. ( 16920116 )
2006
28
Enterocele: what is the clinical implication? ( 17106819 )
2006
29
Stapled transanal rectal resection under laparoscopic surveillance for rectocele and concomitant enterocele. ( 16583290 )
2006
30
Transvaginal repair of enterocele and vaginal vault prolapse using autologous fascia lata graft. ( 16817089 )
2006
31
Anatomy of the sigmoid colon, rectum, and the rectovaginal pouch in women with enterocele and anterior rectal wall procidentia. ( 16287126 )
2006
32
Posterior compartment prolapse on two-dimensional and three-dimensional pelvic floor ultrasound: the distinction between true rectocele, perineal hypermobility and enterocele. ( 15973648 )
2005
33
Bilateral iliococcygeal fixation for vaginal vault prolapse and enterocele repair using a new suturing device--the digital needle driver. ( 16045532 )
2005
34
Metastatic colon carcinoma found within an enterocele sac: a case report. ( 15647967 )
2005
35
Enterocele associated with rectocele revealed by dynamic pelvic CT. ( 15803223 )
2005
36
Laparoscopic treatment of enterocele: a 3-year evaluation. ( 15089832 )
2004
37
The pathophysiology of an enterocele and its management. ( 15203582 )
2004
38
Anterior enterocele: a report of three cases. ( 15278250 )
2004
39
Severe intra-abdominal bleeding following stapled mucosectomy due to enterocele: report of a case. ( 15057589 )
2004
40
Transection of a colonic diverticulum during enterocele repair. ( 15663145 )
2004
41
Commentary on: "Posterior culdeplasty: surgical correction of enterocele during vaginal hysterectomy: A preliminary report". 1957. ( 12681861 )
2003
42
Treatment of enterocele by abdominal colporectosacropexy - efficacy on pelvic pressure. ( 12780575 )
2002
43
Diagnosis of posterior enterocele: comparison of rectal ultrasonography with intraoperative diagnosis. ( 11934095 )
2002
44
Enterocele: is there a histologic defect? ( 11576580 )
2001
45
High uterosacral vaginal vault suspension with fascial reconstruction for vaginal repair of enterocele and vaginal vault prolapse. ( 11744906 )
2001
46
Combined abdominoperineal repair of enterocele and rectocele. ( 11862573 )
2001
47
Repair of enterocele and vault prolapse: transvaginal culdosuspension. ( 11383993 )
2001
48
Vaginal vault fixation and prevention of enterocele recurrence by high midline levator myorraphy: physical examination and questionnaire-based follow-up. ( 11805411 )
2001
49
Vaginal vault suspension and enterocele repair by Richardson-Saye laparoscopic technique: description of training technique and results. ( 11303992 )
2001
50
Functional and anatomic follow-up of enterocele repairs. ( 11506843 )
2001

Variations for Enterocele

Expression for Enterocele

Search GEO for disease gene expression data for Enterocele.

Pathways for Enterocele

GO Terms for Enterocele

Biological processes related to Enterocele according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of fat cell differentiation GO:0045600 9.16 CMKLR1 WDFY2
2 endochondral ossification GO:0001958 8.96 COL1A1 MMP13
3 platelet activation GO:0030168 8.8 CD9 COL1A1 F2

Sources for Enterocele

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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