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MCID: ENT011
MIFTS: 54

Enterocolitis

Categories: Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Enterocolitis

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MalaCards integrated aliases for Enterocolitis:

Name: Enterocolitis 58 30 56 17 74

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive


HPO:

33
enterocolitis:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

OMIM 58 226150
ICD10 34 A04.7
MedGen 43 C0014356
UMLS 74 C0014356
Sources

Summaries for Enterocolitis

About this section
MalaCards based summary : Enterocolitis is related to perinatal necrotizing enterocolitis and autoinflammation with infantile enterocolitis. An important gene associated with Enterocolitis is NLRC4 (NLR Family CARD Domain Containing 4), and among its related pathways/superpathways are Innate Immune System and Complement and coagulation cascades. The drugs Ceftriaxone and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and breast, and related phenotypes are hematochezia and abdominal distention

Wikipedia : 77 Enterocolitis or coloenteritis is an inflammation of the digestive tract, involving enteritis of the... more...

Description from OMIM: 226150
Sources

Related Diseases for Enterocolitis

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Diseases related to Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 306)
# Related Disease Score Top Affiliating Genes
1 perinatal necrotizing enterocolitis 34.5 FABP2 TLR4
2 autoinflammation with infantile enterocolitis 34.4 NLRC4 SLC30A6
3 ileitis 30.0 FABP2 TLR4
4 salmonellosis 29.6 NLRC4 TLR4
5 hemolytic uremic syndrome, atypical 1 29.3 C3 CD46 CFB CFH CFHR1 CFHR3
6 hemolytic-uremic syndrome 27.3 C3 CD46 CFB CFH CFHR1 CFHR3
7 mastocytic enterocolitis 12.5
8 clostridium difficile colitis 11.8
9 short bowel syndrome 11.4
10 hirschsprung disease 1 11.4
11 hypoganglionosis 11.3
12 5-oxoprolinase deficiency 11.0
13 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.0
14 hemolytic uremic syndrome, atypical 2 11.0
15 hemolytic uremic syndrome, atypical 3 11.0
16 hemolytic uremic syndrome, atypical 4 11.0
17 hemolytic uremic syndrome, atypical 5 11.0
18 hemolytic uremic syndrome, atypical 6 11.0
19 intestinal perforation 10.5
20 leukemia 10.4
21 heart disease 10.3
22 familial cold autoinflammatory syndrome 10.3 NLRC4 SLC30A6
23 familial cold autoinflammatory syndrome 4 10.3 NLRC4 SLC30A6
24 diarrhea 10.3
25 colitis 10.3
26 hypoxia 10.3
27 legionnaires' disease 10.2 NLRC4 TLR4
28 proliferative glomerulonephritis 10.2 C3 CFH
29 appendicitis 10.2
30 ischemia 10.2
31 inflammatory bowel disease 10.2
32 intussusception 10.2
33 acute leukemia 10.2
34 arthritis 10.1
35 crohn's disease 10.1
36 legionellosis 10.1 NLRC4 TLR4
37 complement deficiency 10.1 C3 CFH
38 patent ductus arteriosus 1 10.1
39 multifocal choroiditis 10.1 CFB CFH
40 neisseria meningitidis infection 10.1 C3 CD46 TLR4
41 choroiditis 10.1 CFB CFH
42 leukemia, acute myeloid 10.1
43 thrombocytopenia 10.1
44 milk allergy 10.1
45 mucormycosis 10.1
46 myeloid leukemia 10.1
47 kuhnt-junius degeneration 10.1 CFB CFH
48 neutropenia 10.0
49 megacolon 10.0
50 gastroenteritis 10.0

Graphical network of the top 20 diseases related to Enterocolitis:



Diseases related to Enterocolitis
Sources

Symptoms & Phenotypes for Enterocolitis

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Human phenotypes related to Enterocolitis:

33
# Description HPO Frequency HPO Source Accession
1 hematochezia 33 HP:0002573
2 abdominal distention 33 HP:0003270
3 ulcerative colitis 33 HP:0100279
4 enterocolitis 33 HP:0004387

Symptoms via clinical synopsis from OMIM:

58
G I:
ulcerative colitis
bloody diarrhea
pseudomembranous enterocolitis

Abdomen:
swelling

Clinical features from OMIM:

226150

MGI Mouse Phenotypes related to Enterocolitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 C3 CFB CFH CFI FABP2 TLR4
Sources

Drugs & Therapeutics for Enterocolitis

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Drugs for Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 363)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
2
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
3
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
4
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
5
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68-04-2
6
Caffeine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-08-2 2519
7 Poractant alfa Approved Phase 4,Not Applicable 129069-19-8
8
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
9
Adalimumab Approved Phase 4 331731-18-1 16219006
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-02-2 5743
11
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1177-87-3
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 22916-47-8 4189
13
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
14
Iodine Approved, Investigational Phase 4 7553-56-2 807
15
Zinc Approved, Investigational Phase 4 7440-66-6 32051
16
Nifedipine Approved Phase 4,Phase 3,Not Applicable 21829-25-4 4485
17
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
18
Histamine Approved, Investigational Phase 4 51-45-6 774
19
Ranitidine Approved Phase 4 66357-59-3, 66357-35-5 3001055
20
Methyldopa Approved Phase 4 555-30-6 38853
21
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
22
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
23
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 77-92-9 311
24
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
25
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1406-16-2
26
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 5280795 6221
27
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
28
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Omega 3 Fatty Acid Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 Soy Bean Phase 4,Phase 2,Phase 1,Not Applicable
33 Olive Phase 4,Phase 1,Phase 2,Not Applicable
34 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Polyethylene glycol 3350 Phase 4,Not Applicable
36 Cathartics Phase 4,Phase 1,Phase 2
37 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Laxatives Phase 4,Phase 1,Phase 2
39 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2,Not Applicable
43 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Betamethasone benzoate Phase 4,Phase 3,Phase 2,Not Applicable
48 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
50 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 590)
# Name Status NCT ID Phase Drugs
1 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
2 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Rate of Bronchopulmonary Dysplasia in Preterms Neonates: a Trial Comparing SMOFlipid and Medialipide Unknown status NCT02853253 Phase 4
5 Clostridial Infection and Oral Lavage -Improving Treatment Before Illness Becomes Severe Unknown status NCT01630096 Phase 4 Nu-Lytely
6 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
7 Effect of Probiotics (Bio-Three) in Children's Enterocolitis Completed NCT00463190 Phase 4 Biothree
8 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
9 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
10 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
11 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4 Nystatin
12 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
13 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
14 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
15 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4 Gastrografin;Sterile water
16 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
17 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
18 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
19 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin
20 Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis Recruiting NCT02343562 Phase 4
21 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
22 Stress Ulcer Prophylaxis Versus Placebo in Critically Ill Infants With Congenital Heart Disease Recruiting NCT03667703 Phase 4 Ranitidine;Placebo
23 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
24 Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor Recruiting NCT02430233 Phase 4 micronized progesterone 400 mg (Utrogestan)
25 Vaginal Versus Intramuscular Progesterone for the Prevention of Recurrent Preterm Birth Recruiting NCT02913495 Phase 4 Vaginal Progesterone;Intramuscular Progesterone
26 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
27 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
28 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
29 Comparing the Effectiveness of IV Bezlotoxumab Versus Placebo in Decreasing Morbidity and Mortality in Patients With Fulminant C. Diff Requiring Surgery. Not yet recruiting NCT03756454 Phase 4
30 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
31 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
32 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
33 Addition of Lactobacillus to Metronidazole in Treatment of CDAD Withdrawn NCT00304863 Phase 4 Lactobacillus GG
34 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
35 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
36 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
37 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
38 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
39 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
40 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Unknown status NCT01503606 Phase 3 Cefazolin;Clarithromycin;Cefazolin;Clarithromycin
41 Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis Unknown status NCT01652118 Phase 3 clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia;Saline
42 Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants Unknown status NCT03024814 Phase 3 Acetaminophen;Dextrose 5
43 Progesterone and Cervical Pessary in Twins Unknown status NCT03058536 Phase 2, Phase 3 Vaginal Progesterone
44 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
45 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
46 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
47 Cerclage for Singletons With Short Cervix Without Prior Preterm Birth Unknown status NCT02716922 Phase 3
48 Modulation of the Intestinal Flora With the Probiotic VIVOMIXXâ„¢ in Pregnant Women at Risk of Metabolic Complications Unknown status NCT02768818 Phase 3
49 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
50 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3

Search NIH Clinical Center for Enterocolitis

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Genetic Tests for Enterocolitis

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Genetic tests related to Enterocolitis:

# Genetic test Affiliating Genes
1 Enterocolitis 30
Sources

Anatomical Context for Enterocolitis

About this section

MalaCards organs/tissues related to Enterocolitis:

42
Colon, Heart, Breast, Brain, Cervix, Small Intestine, Lung
Sources

Publications for Enterocolitis

About this section

Articles related to Enterocolitis:

(show top 50) (show all 3580)
# Title Authors Year
1
Intestinal failure associated cholestasis in surgical necrotizing enterocolitis and spontaneous intestinal perforation. ( 30413273 )
2019
2
Cytomegalovirus enterocolitis in a patient with dihydropyrimidine dehydrogenase deficiency after capecitabine treatment: A case report. ( 30831507 )
2019
3
Comment on: Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis. ( 28911253 )
2019
4
Associations between Red Blood Cell Transfusions and Necrotizing Enterocolitis in Very Low Birth Weight Infants: Ten-Year Data of a Tertiary Neonatal Unit. ( 30650594 )
2019
5
Fulminant pseudomembranous enterocolitis caused by Klebsiella oxytoca: an autopsy case report. ( 30652002 )
2019
6
Acute-on-chronic food protein-induced enterocolitis syndrome in an exclusively breast-fed infant. ( 30656011 )
2019
7
Regulation of ROS-NF-κB axis by tuna backbone derived peptide ameliorates inflammation in necrotizing enterocolitis. ( 30656693 )
2019
8
Food protein-induced enterocolitis syndrome: guidelines summary and practice recommendations. ( 30656696 )
2019
9
Necrotizing Enterocolitis and the Preterm Infant Microbiome. ( 30680646 )
2019
10
Role of NO and other vascular mediators in the etiopathogenesis of necrotizing enterocolitis. ( 30844734 )
2019
11
Use of serum citrulline concentrations from routine newborn screen as a biomarker for necrotizing enterocolitis. ( 30852646 )
2019
12
Abdominal Ultrasound and Abdominal Radiograph to Diagnose Necrotizing Enterocolitis in Extremely Preterm Infants. ( 30854167 )
2019
13
Autoinflammation with Infantile Enterocolitis Associated with Recurrent Perianal Abscesses. ( 30864118 )
2019
14
Necrotizing Enterocolitis: Long Term Complications. ( 30864508 )
2019
15
Early cerebral and intestinal oxygenation in the risk assessment of necrotizing enterocolitis in preterm infants. ( 30870625 )
2019
16
Necrotizing enterocolitis in term neonates: A different disease process? ( 30871720 )
2019
17
Inhibiting hydrogen sulfide production in umbilical stem cells reduces their protective effects during experimental necrotizing enterocolitis. ( 30879750 )
2019
18
Retrospective study identified fish and milk as the main culprits in cases of food protein-induced enterocolitis syndrome. ( 30883926 )
2019
19
Meconium-stained amniotic fluid as a risk factor for necrotizing enterocolitis in very low birth weight preterm infants: a retrospective cohort study. ( 30885024 )
2019
20
Relationship of Necrotizing Enterocolitis Rates to Adoption of Prevention Practices in US Neonatal Intensive Care Units. ( 30893097 )
2019
21
Gastrointestinal sequelae and growth impairment at school age following necrotising enterocolitis in the newborn period. ( 30896048 )
2019
22
Single strain versus multispecies probiotic on necrotizing enterocolitis and faecal IgA levels in very low birth weight preterm neonates: A randomized clinical trial. ( 30898471 )
2019
23
Caveolin 1 is Associated with Upregulated Claudin 2 in Necrotizing Enterocolitis. ( 30899070 )
2019
24
B-lymphocyte-intrinsic and -extrinsic defects in secretory immunoglobulin A production in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated enterocolitis. ( 30908942 )
2019
25
Metabolism of Milk Oligosaccharides in Preterm Pigs Sensitive to Necrotizing Enterocolitis. ( 30931310 )
2019
26
Necrotizing Enterocolitis and Spontaneous Intestinal Perforation: A Spatiotemporal Case Cluster Analysis. ( 30937409 )
2019
27
Inflammatory Bowel Disease Serological Immune Markers Anti-Saccharomyces cerevisiae Mannan Antibodies and Outer Membrane Porin C are Potential Biomarkers for Hirschsprung-associated Enterocolitis. ( 30964819 )
2019
28
Increased risk of rickets but not fractures during childhood and adolescence following necrotizing enterocolitis among children born preterm in Sweden. ( 30970375 )
2019
29
Eosinophilic enterocolitis: A case report and literature review. ( 30139591 )
2019
30
Interleukin-6 serum levels predict surgical intervention in infants with necrotizing enterocolitis. ( 30213531 )
2019
31
Cooking influence in tolerance acquisition in egg-induced acute food protein enterocolitis syndrome. ( 30316559 )
2019
32
Food Protein-induced Enterocolitis Syndrome: Data From a Multicenter Retrospective Study in Spain. ( 30320669 )
2019
33
Is avocado an emerging culprit in food protein-induced enterocolitis syndrome? ( 30326325 )
2019
34
Severe acute radiation-induced enterocolitis after combined palbociclib and palliative radiotherapy treatment. ( 30336956 )
2019
35
Risk factors for the development of post-operative enterocolitis in short segment Hirschsprung's disease. ( 30386902 )
2019
36
Standardized Nutrition Protocol for Very Low-Birth-Weight Infants Resulted in Less Use of Parenteral Nutrition and Associated Complications, Better Growth, and Lower Rates of Necrotizing Enterocolitis. ( 30414179 )
2019
37
Caffeine exposure and acute kidney injury in premature infants with necrotizing enterocolitis and spontaneous intestinal perforation. ( 30415418 )
2019
38
Current use of probiotics to prevent necrotising enterocolitis. ( 30464004 )
2019
39
Inhibition of miR-124 improves neonatal necrotizing enterocolitis via an MYPT1 and TLR9 signal regulation mechanism. ( 30480807 )
2019
40
Bifidobacterium may benefit the prevention of necrotizing enterocolitis in preterm infants: A systematic review and meta-analysis. ( 30500473 )
2019
41
Neutropenic enterocolitis in patients with FLT3 mutated acute myeloid leukemia undergoing induction chemotherapy with midostaurin. ( 30506467 )
2019
42
Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia. ( 30527488 )
2019
43
Feeding preterm infants with formula rather than donor breast milk is associated with faster rates of short-term growth, but increased risk of developing necrotising enterocolitis. ( 30315005 )
2019
44
Necrotizing enterocolitis attenuates developmental heart rate variability increases in newborn rats. ( 30298607 )
2019
45
Low rate of necrotizing enterocolitis in extremely low birth weight infants using a hospital-based preterm milk bank. ( 30291318 )
2019
46
Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes. ( 30281170 )
2019
47
Food protein-induced enterocolitis syndrome: Increased prevalence of this great unknown-results of the PREVALE study. ( 30244024 )
2019
48
Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral Center. ( 30243880 )
2019
49
Probiotics and the prevention of necrotizing enterocolitis. ( 30241961 )
2019
50
Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. ( 30236604 )
2019
Sources

Variations for Enterocolitis

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Expression for Enterocolitis

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Search GEO for disease gene expression data for Enterocolitis.
Sources

Pathways for Enterocolitis

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Pathways related to Enterocolitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 67
Show member pathways
 13.6 C3 CD46 CFB CFH CFHR3 CFI
2
Complement and coagulation cascades 1 38
11.7 C3 CD46 CFB CFH CFI
3
Complement Pathway 65
Show member pathways
 11.65 C3 CD46 CFB CFH
4
Creation of C4 and C2 activators 67
Show member pathways
 11.59 C3 CD46 CFB CFH CFHR3 CFI
5
Staphylococcus aureus infection 38
11.39 C3 CFB CFH CFI
6
Legionellosis 38
11.28 C3 NLRC4 TLR4
7
Immune response Lectin induced complement pathway 23
Show member pathways
 11.23 C3 CD46 CFB CFH CFHR3 CFI
Sources

GO Terms for Enterocolitis

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Cellular components related to Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 C3 CFB CFH CFHR1 CFHR5 CFI
2 extracellular exosome GO:0070062 9.63 C3 CD46 CFB CFH CFHR3 CFI
3 extracellular space GO:0005615 9.43 C3 CFB CFH CFHR1 CFHR3 CFI
4 blood microparticle GO:0072562 9.02 C3 CFB CFH CFHR1 CFHR3

Biological processes related to Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.72 C3 CD46 CFB NLRC4 TLR4
2 innate immune response GO:0045087 9.7 C3 CD46 CFB CFH CFI NLRC4
3 complement activation, classical pathway GO:0006958 9.61 C3 CD46 CFI
4 complement activation GO:0006956 9.56 C3 CFB CFH CFHR1
5 positive regulation of interleukin-10 production GO:0032733 9.48 CD46 TLR4
6 activation of innate immune response GO:0002218 9.46 NLRC4 TLR4
7 interleukin-1 beta secretion GO:0050702 9.4 NLRC4 TLR4
8 positive regulation of cytolysis GO:0045919 9.37 CFHR1 CFHR5
9 complement activation, alternative pathway GO:0006957 9.26 C3 CFB CFH CFHR5
10 regulation of complement activation GO:0030449 9.17 C3 CD46 CFB CFH CFHR1 CFHR5

Molecular functions related to Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.62 CFB CFI
Sources

Sources for Enterocolitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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