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MCID: ENT011
MIFTS: 53

Enterocolitis

Categories: Gastrointestinal diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Enterocolitis

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MalaCards integrated aliases for Enterocolitis:

Name: Enterocolitis 57 29 55 73

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
enterocolitis:
Inheritance autosomal recessive inheritance


Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 226150
MedGen 42 C0014356
ICD10 33 A04.7
UMLS 73 C0014356
Sources

Summaries for Enterocolitis

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MalaCards based summary : Enterocolitis is related to perinatal necrotizing enterocolitis and autoinflammation with infantile enterocolitis. An important gene associated with Enterocolitis is NLRC4 (NLR Family CARD Domain Containing 4), and among its related pathways/superpathways are Innate Immune System and Complement and coagulation cascades. The drugs Ceftriaxone and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include colon, heart and liver, and related phenotypes are hematochezia and abdominal distention

Wikipedia : 76 Enterocolitis or coloenteritis is an inflammation of the digestive tract, involving enteritis of the... more...

Description from OMIM: 226150
Sources

Related Diseases for Enterocolitis

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Diseases related to Enterocolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 perinatal necrotizing enterocolitis 34.3 FABP2 TLR4
2 autoinflammation with infantile enterocolitis 34.3 NLRC4 SLC30A6
3 hemolytic uremic syndrome, atypical 1 30.1 C3 CD46 CFB CFH CFHR1 CFHR3
4 ileitis 29.9 FABP2 TLR4
5 salmonellosis 29.7 NLRC4 TLR4
6 hemolytic-uremic syndrome 28.1 C3 CD46 CFB CFH CFHR1 CFHR3
7 mastocytic enterocolitis 12.4
8 clostridium difficile colitis 11.6
9 short bowel syndrome 11.3
10 hirschsprung disease 1 11.3
11 hypoganglionosis 11.3
12 5-oxoprolinase deficiency 11.0
13 pigmentary disorder, reticulate, with systemic manifestations, x-linked 11.0
14 hemolytic uremic syndrome, atypical 2 11.0
15 hemolytic uremic syndrome, atypical 3 11.0
16 hemolytic uremic syndrome, atypical 4 11.0
17 hemolytic uremic syndrome, atypical 5 11.0
18 hemolytic uremic syndrome, atypical 6 11.0
19 intestinal perforation 10.5
20 colitis 10.2
21 familial cold autoinflammatory syndrome 10.2 NLRC4 SLC30A6
22 familial cold autoinflammatory syndrome 4 10.2 NLRC4 SLC30A6
23 diarrhea 10.2
24 appendicitis 10.2
25 legionnaires' disease 10.2 NLRC4 TLR4
26 heart disease 10.1
27 anterior uveitis 10.1 CFH TLR4
28 multifocal choroiditis 10.1 CFB CFH
29 choroiditis 10.1 CFB CFH
30 inflammatory bowel disease 10.1
31 proliferative glomerulonephritis 10.1 C3 CFH
32 legionellosis 10.1 NLRC4 TLR4
33 kuhnt-junius degeneration 10.1 CFB CFH
34 milk allergy 10.1
35 megacolon 10.0
36 ischemia 10.0
37 hypoxia 10.0
38 thrombotic thrombocytopenic purpura 10.0 CD46 CFH
39 neisseria meningitidis infection 10.0 C3 CD46 TLR4
40 intussusception 10.0
41 hypoplastic left heart syndrome 1 10.0
42 arthritis 10.0
43 crohn's disease 10.0
44 hypoplastic left heart syndrome 10.0
45 leukemia 10.0
46 toxic megacolon 10.0
47 cytomegalovirus infection 10.0
48 de novo thrombotic microangiopathy after kidney transplantation 10.0 CFH CFI
49 familial drusen 10.0 CFH CFI
50 leukemia, acute myeloid 9.9

Graphical network of the top 20 diseases related to Enterocolitis:



Diseases related to Enterocolitis
Sources

Symptoms & Phenotypes for Enterocolitis

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Symptoms via clinical synopsis from OMIM:

57
G I:
ulcerative colitis
bloody diarrhea
pseudomembranous enterocolitis

Abdomen:
swelling


Clinical features from OMIM:

226150

Human phenotypes related to Enterocolitis:

32
# Description HPO Frequency HPO Source Accession
1 hematochezia 32 HP:0002573
2 abdominal distention 32 HP:0003270
3 ulcerative colitis 32 HP:0100279
4 enterocolitis 32 HP:0004387

MGI Mouse Phenotypes related to Enterocolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.1 C3 CFB CFH CFI FABP2 TLR4
Sources

Drugs & Therapeutics for Enterocolitis

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Drugs for Enterocolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 359)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
2
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 378-44-9 9782
3
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-83-0 5994
4
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15687-27-1 3672
5
Caffeine Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-08-2 2519
6 Poractant alfa Approved Phase 4,Not Applicable 129069-19-8
7
Indomethacin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 53-86-1 3715
8
Adalimumab Approved Phase 4 331731-18-1 16219006
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 1177-87-3
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-02-2 5743
11
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1 22916-47-8 4189
13
Iodine Approved, Investigational Phase 4 7553-56-2 807
14
Zinc Approved, Investigational Phase 4 7440-66-6
15
Nifedipine Approved Phase 4,Phase 3,Not Applicable 21829-25-4 4485
16
Metronidazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 443-48-1 4173
17
Labetalol Approved Phase 4,Phase 2,Phase 3 36894-69-6 3869
18
Methyldopa Approved Phase 4 555-30-6 38853
19
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
20
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
21
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
22
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
23
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 5280795 6221
24
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
25
Beta carotene Approved, Nutraceutical Phase 4 7235-40-7
26 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Betamethasone sodium phosphate Phase 4,Phase 3,Phase 2,Not Applicable
31 Betamethasone-17,21-dipropionate Phase 4,Phase 3,Phase 2,Not Applicable
32 Betamethasone Valerate Phase 4,Phase 3,Phase 2,Not Applicable 2152-44-5
33 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Betamethasone benzoate Phase 4,Phase 3,Phase 2,Not Applicable
37 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
41 Acidophilus Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable
42 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Caffeine citrate Phase 4,Phase 3,Phase 2,Not Applicable
47 Citrate Phase 4,Phase 3,Phase 2,Not Applicable
48 Purinergic P1 Receptor Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
49 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
50 Anticoagulants Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 551)
# Name Status NCT ID Phase Drugs
1 The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis Unknown status NCT01278017 Phase 4 ceftriaxone
2 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
3 The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) Unknown status NCT01765998 Phase 4 Probiotic;Placebo
4 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
5 Effect of Probiotics (Bio-Three) in Children's Enterocolitis Completed NCT00463190 Phase 4 Biothree
6 Intestinal Inflammation in Ankylosing Spondylitis and the Effects of Adalimumab on Mucosal Healing Completed NCT01174186 Phase 4 Adalimumab
7 Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
8 A Randomized Trial Comparing the Impact of One Versus Two Courses of Antenatal Steroids (ACS) on Neonatal Outcome Completed NCT00201643 Phase 4 Betamethasone or Dexamethasone (2nd course of ACS);Placebo
9 Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants Completed NCT01531192 Phase 4 Nystatin
10 A Randomised Controlled Trial of Iodide Supplementation in Preterm Infants Follow-up at 2 Years Completed NCT00638092 Phase 4 sodium iodide;Sodium Chloride
11 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
12 Ibuprofen and Renal Function in Premature Infants Completed NCT00217191 Phase 4 Ibuprofen
13 Impact of Oral Application of Gastrografin on the Meconium Evacuation in Very Low Birth Weight Infants Completed NCT01515696 Phase 4 Gastrografin;Sterile water
14 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
15 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
16 MRI and Neurodevelopment in Preterm Infants Following Administration of High-Dose Caffeine Completed NCT00809055 Phase 4 Caffeine citrate
17 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin
18 Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis Recruiting NCT02343562 Phase 4
19 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
20 OPTIMIST-A Trial: Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on CPAP Recruiting NCT02140580 Phase 4
21 Vaginal Progesterone for the Prolongation of Pregnancy After Arrested Pre-term Labor Recruiting NCT02430233 Phase 4 micronized progesterone 400 mg (Utrogestan)
22 Vaginal Versus Intramuscular Progesterone for the Prevention of Recurrent Preterm Birth Recruiting NCT02913495 Phase 4 Vaginal Progesterone;Intramuscular Progesterone
23 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
24 TRAP Intervention STudy: Early Versus Late Intervention for Twin Reversed Arterial Perfusion Sequence Recruiting NCT02621645 Phase 4
25 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
26 Rate of Bronchopulmonary Dysplasia in Preterms Neonates: a Trial Comparing SMOFlipid and Medialipide Not yet recruiting NCT02853253 Phase 4
27 The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study Terminated NCT00164099 Phase 4 Synbiotic 2000
28 Sodium Supplementation and Growth in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
29 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
30 Addition of Lactobacillus to Metronidazole in Treatment of CDAD Withdrawn NCT00304863 Phase 4 Lactobacillus GG
31 Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months Withdrawn NCT02774317 Phase 4
32 RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section Withdrawn NCT02009098 Phase 4 Cefuroxime
33 Comparing Ibuprofen And Indomethacin For The Treatment Of The Patent Ductus Arteriosus in Very Premature Babies Withdrawn NCT00470743 Phase 4 Ibuprofen;Indomethacin
34 Effect of Saccharomyces Boulardii on Necrotizing Enterocolitis in Very Low Birth Weight Infants Unknown status NCT01315821 Phase 3 Saccharomyces boulardii;Placebo
35 Randomized Study of Pessary Versus Standard Management in Women With Increased Chance of Premature Birth Unknown status NCT00735137 Phase 3
36 Cysteine Supplementation in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
37 Duration of Antibiotics Treatment With Cefazolin and Clarithromycin in Women With Preterm Premature Rupture of Membrane Unknown status NCT01503606 Phase 3 Cefazolin;Clarithromycin;Cefazolin;Clarithromycin
38 Clarithromycin Prophylaxis in Preterm Infants Colonisation With Ureaplasma Urealyticum and Mycoplasma Hominis Unknown status NCT01652118 Phase 3 clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia;Saline
39 Prophylactic Acetaminophen for Prevention Intraventricular Hemorrhage in Premature Infants Unknown status NCT03024814 Phase 3 Acetaminophen;Dextrose 5
40 Pessary as Adjunctive Therapy to Cerclage for the Prevention of Preterm Birth Unknown status NCT02678026 Phase 3
41 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Unknown status NCT02336243 Phase 3
42 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
43 Modulation of the Intestinal Flora With the Probiotic VIVOMIXXâ„¢ in Pregnant Women at Risk of Metabolic Complications Unknown status NCT02768818 Phase 3
44 Lactobacillus Reuteri for Prevention of Necrotizing Enterocolitis in Very Low-birth Weight Infants Completed NCT01531179 Phase 3 Lactobacillus reuteri;Placebo
45 Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants Completed NCT01868737 Phase 3
46 The Efficacy of Symbiotic on Cytokines Completed NCT01899677 Phase 3 symbiotic
47 Role of Probiotics for Prevention of NEC in Preterm VLBW Infants Completed NCT02650869 Phase 3
48 Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants Completed NCT01340469 Phase 3
49 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
50 A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea Completed NCT00106509 Phase 3 tolevamer potassium-sodium (GT267-004)

Search NIH Clinical Center for Enterocolitis

Sources

Genetic Tests for Enterocolitis

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Genetic tests related to Enterocolitis:

# Genetic test Affiliating Genes
1 Enterocolitis 29
Sources

Anatomical Context for Enterocolitis

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MalaCards organs/tissues related to Enterocolitis:

41
Colon, Heart, Liver, Small Intestine, Breast, Neutrophil, Lung
Sources

Publications for Enterocolitis

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Articles related to Enterocolitis:

(show top 50) (show all 1760)
# Title Authors Year
1
Hydrogen Sulfide Donor GYY4137 Acts Through Endothelial Nitric Oxide to Protect Intestine in Murine Models of Necrotizing Enterocolitis and Intestinal Ischemia. ( 30527488 )
2019
2
Role of delayed cord clamping in prevention of necrotizing enterocolitis in preterm neonates: a systematic review. ( 28826265 )
2019
3
Food protein-induced enterocolitis syndrome by fish: Not necessarily a restricted diet. ( 29052246 )
2018
4
New insights into necrotizing enterocolitis: From laboratory observation to personalized prevention and treatment. ( 29980346 )
2018
5
Necrotizing enterocolitis in the setting of milk allergy after pediatric living donor liver transplantation. ( 29218832 )
2018
6
Suspected necrotising enterocolitis after surgery for CHD: an opportunity to improve practice and outcomes. ( 29409546 )
2018
7
Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet. ( 29877722 )
2018
8
Necrotizing enterocolitis as a prognostic factor for the neurodevelopmental outcome of preterm infants - match control study after 2years. ( 29409620 )
2018
9
Staging of necrotising enterocolitis by Bell's criteria is supported by a statistical pattern analysis of clinical and radiological variables. ( 29926969 )
2018
10
Necrotizing Enterocolitis Cases Associated with Nosocomial Enterovirus Transmission in a Neonatal Unit. ( 29389824 )
2018
11
Increased incidence of necrotizing enterocolitis associated with routine administration of Inflorana8c in extremely preterm infants. ( 29888655 )
2018
12
Characteristics and incidence of transfusion-associated necrotizing enterocolitis in the UKCharacteristics and incidence of transfusion-associated necrotizing enterocolitis in the UK. ( 29945481 )
2018
13
Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). ( 29930978 )
2018
14
Nutrition Management of Necrotizing Enterocolitis. ( 29940075 )
2018
15
Candidate gene analysis in pathogenesis of surgically and non-surgically treated necrotizing enterocolitis in preterm infants. ( 28770467 )
2018
16
Gastrointestinal sequelae after surgery for necrotising enterocolitis: a systematic review and meta-analysis. ( 29945925 )
2018
17
Routine Supplementation of Lactobacillus rhamnosus GG and Risk of Necrotizing Enterocolitis in Very Low Birth Weight Infants. ( 29402455 )
2018
18
Early onset necrotising enterocolitis in association with congenital diaphragmatic hernia in a term baby. ( 29954766 )
2018
19
Rho Kinase Inhibition Maintains Intestinal and Vascular Barrier Function by Upregulation of Occludin in Experimental Necrotizing Enterocolitis. ( 29927318 )
2018
20
Technical aspects of abdominal ultrasound and color Doppler assessment of bowel viability in necrotizing enterocolitis. ( 29368011 )
2018
21
Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. ( 29885660 )
2018
22
The Microbiome and Metabolome of Preterm Infant Stool Are Personalized and Not Driven by Health Outcomes, Including Necrotizing Enterocolitis and Late-Onset Sepsis. ( 29875143 )
2018
23
Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis. ( 29933378 )
2018
24
Preterm infant gut microbial patterns related to the development of necrotizing enterocolitis. ( 29909714 )
2018
25
Body Composition following Necrotising Enterocolitis in Preterm Infants. ( 29393261 )
2018
26
Clostridial strain-specific characteristics associated with necrotizing enterocolitis. ( 29352082 )
2018
27
Drug-Induced Enterocolitis: Prevention and management in primary care. ( 29417737 )
2018
28
TNF-I+ induces autophagy through ERK1/2 pathway to regulate apoptosis in neonatal necrotizing enterocolitis model cells IEC-6. ( 29950141 )
2018
29
Development of Food Protein-Induced Enterocolitis Syndrome (FPIES) to egg following Immunoglobulin E (IgE)-mediated egg allergy<sup/>. ( 29859249 )
2018
30
Necrotizing Enterocolitis in Infants with Hypoplastic Left Heart Syndrome Following Stage 1 Palliation or Heart Transplant. ( 29392349 )
2018
31
Acute enterocolitis causing an appendicitis like symdrome. ( 29932094 )
2018
32
Topiramate for Seizures in Preterm Infants and the Development of Necrotizing Enterocolitis. ( 29903834 )
2018
33
[Intrauterine necrotizing enterocolitis in premature newborns]. ( 29393025 )
2018
34
Food Protein-Induced Enterocolitis Syndrome Causing Hypovolemic Shock and Methemoglobinemia. ( 29854475 )
2018
35
Shift from IgE-mediated cow's milk allergy to food protein induced enterocolitis syndrome in two infants. ( 29444343 )
2018
36
Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. ( 29883324 )
2018
37
Food protein-induced enterocolitis syndrome: a challenging diagnosis. ( 29437805 )
2018
38
Vital signs analysis algorithm detects inflammatory response in premature infants with late onset sepsis and necrotizing enterocolitis. ( 29351876 )
2018
39
Bowel Ultrasound for the Diagnosis of Necrotizing Enterocolitis: A Meta-analysis. ( 29369246 )
2018
40
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants. ( 29422156 )
2018
41
Loss of tolerance for fishes previously tolerated in children with fish food protein induced enterocolitis syndrome. ( 29338963 )
2018
42
Preterm infants undergoing laparotomy for necrotizing enterocolitis or spontaneous intestinal perforation display evidence of impaired cerebrovascular autoregulation. ( 29454185 )
2018
43
Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. ( 29360809 )
2018
44
Metabolic acidosis as Food Protein Induced Enterocolitis Syndrome (FPIES) onset in a newborn. ( 29747671 )
2018
45
Necrotizing Enterocolitis in Two Siblings and an Unrelated Infant with Overlapping Chromosome 6q25 Deletions. ( 29928179 )
2018
46
Food protein-induced enterocolitis syndrome: a review of the new guidelines. ( 29441147 )
2018
47
Clostridium neonatale sp. nov. linked to necrotizing enterocolitis in neonates and a clarification of species assignable to the genus Clostridium (Prazmowski 1880) emend. Lawson and Rainey 2016. ( 29889020 )
2018
48
Significance of dynamic evolution of TNF-I+, IL-6 and intestinal fatty acid-binding protein levels in neonatal necrotizing enterocolitis. ( 29399120 )
2018
49
Suspicious Yersinia granulomatous enterocolitis mimicking appendicitis. ( 30323099 )
2018
50
Necrotizing enterocolitis and appendicitis in preterm infants. ( 30048607 )
2018
Sources

Variations for Enterocolitis

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Expression for Enterocolitis

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Search GEO for disease gene expression data for Enterocolitis.
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Pathways for Enterocolitis

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Pathways related to Enterocolitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.6 C3 CD46 CFB CFH CFHR3 CFI
2
Complement and coagulation cascades 1 37
11.7 C3 CD46 CFB CFH CFI
3
Complement Pathway 64
Show member pathways
 11.65 C3 CD46 CFB CFH
4
Creation of C4 and C2 activators 66
Show member pathways
 11.59 C3 CD46 CFB CFH CFHR3 CFI
5
Staphylococcus aureus infection 37
11.31 C3 CFB CFH CFI
6
Legionellosis 37
11.28 C3 NLRC4 TLR4
7
Immune response Lectin induced complement pathway 22
Show member pathways
 11.23 C3 CD46 CFB CFH CFHR3 CFI
Sources

GO Terms for Enterocolitis

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Cellular components related to Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 C3 CFB CFH CFHR1 CFHR5 CFI
2 extracellular exosome GO:0070062 9.63 C3 CD46 CFB CFH CFHR3 CFI
3 extracellular space GO:0005615 9.43 C3 CFB CFH CFHR1 CFHR3 CFI
4 blood microparticle GO:0072562 9.02 C3 CFB CFH CFHR1 CFHR3

Biological processes related to Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.72 C3 CD46 CFB NLRC4 TLR4
2 innate immune response GO:0045087 9.7 C3 CD46 CFB CFH CFI NLRC4
3 complement activation, classical pathway GO:0006958 9.61 C3 CD46 CFI
4 complement activation GO:0006956 9.56 C3 CFB CFH CFHR1
5 positive regulation of interleukin-10 production GO:0032733 9.48 CD46 TLR4
6 activation of innate immune response GO:0002218 9.46 NLRC4 TLR4
7 interleukin-1 beta secretion GO:0050702 9.4 NLRC4 TLR4
8 positive regulation of cytolysis GO:0045919 9.37 CFHR1 CFHR5
9 complement activation, alternative pathway GO:0006957 9.26 C3 CFB CFH CFHR5
10 regulation of complement activation GO:0030449 9.17 C3 CD46 CFB CFH CFHR1 CFHR5

Molecular functions related to Enterocolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.8 C3 CFB CFI
Sources

Sources for Enterocolitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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