MCID: ENT007
MIFTS: 29

Enteropathica

Categories: Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Enteropathica

MalaCards integrated aliases for Enteropathica:

Name: Enteropathica 54

Classifications:



Summaries for Enteropathica

MalaCards based summary : Enteropathica is related to acrodermatitis enteropathica, zinc-deficiency type and acrodermatitis. An important gene associated with Enteropathica is SLC39A4 (Solute Carrier Family 39 Member 4), and among its related pathways/superpathways is Metal ion SLC transporters. The drug Zinc has been mentioned in the context of this disorder. Affiliated tissues include breast, skin and eye, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Related Diseases for Enteropathica

Graphical network of the top 20 diseases related to Enteropathica:



Diseases related to Enteropathica

Symptoms & Phenotypes for Enteropathica

MGI Mouse Phenotypes related to Enteropathica:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 ALB OTC PLIN2 SLC30A4 SLC39A4
2 homeostasis/metabolism MP:0005376 9.35 ALB OTC PLIN2 SLC30A4 SLC39A4
3 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4

Drugs & Therapeutics for Enteropathica

Drugs for Enteropathica (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational 7440-66-6 32051

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166

Search NIH Clinical Center for Enteropathica

Genetic Tests for Enteropathica

Anatomical Context for Enteropathica

MalaCards organs/tissues related to Enteropathica:

42
Breast, Skin, Eye, Kidney, Liver, Colon, Pancreas

Publications for Enteropathica

Articles related to Enteropathica:

(show top 50) (show all 390)
# Title Authors Year
1
Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica? ( 30669644 )
2019
2
Acquired acrodermatitis enteropathica secondary to sleeve gastrectomy. ( 30688216 )
2019
3
ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS. ( 29412435 )
2018
4
Acrodermatitis Enteropathica Presenting with Recurrent Diarrhea and Vomiting in an Infant Reluctant to Breastfeed, and a Peculiar Erythemato-Eczematous Eruption around the Oral and Anogenital Regions. ( 29989544 )
2018
5
Acrodermatitis enteropathica from zinc-deficient total parenteral nutrition. ( 30063773 )
2018
6
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 30142747 )
2018
7
Whole Genome Sequencing in an Acrodermatitis Enteropathica Family from the Middle East. ( 30174688 )
2018
8
Acrodermatitis enteropathica: the need for sustained high dose zinc supplementation. ( 30677805 )
2018
9
Acrodermatitis, Enteropathica ( 28722865 )
2017
10
Diagnosis of acrodermatitis enteropathica in resource limited settings. ( 28768674 )
2017
11
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
12
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
13
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
14
Acquired Acrodermatitis Enteropathica: A Case Study. ( 29152424 )
2017
15
Acrodermatitis enteropathica in a patient with short bowel syndrome. ( 29232432 )
2017
16
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
17
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 29469698 )
2017
18
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. ( 27940220 )
2016
19
Acrodermatitis Enteropathica: A Case Report. ( 27196457 )
2016
20
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. ( 26916651 )
2016
21
Acrodermatitis enteropathica in a pair of twins. ( 28435477 )
2016
22
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. ( 26661624 )
2016
23
Acquired acrodermatitis enteropathica as a presenting sign of celiac disease. ( 27222886 )
2016
24
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation. ( 28329567 )
2016
25
Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica. ( 27567652 )
2016
26
Phrynoderm und erworbene Acrodermatitis enteropathica bei stillenden Frauen nach bariatrischer Chirurgie. ( 26513074 )
2015
27
Acrodermatitis enteropathica and other nutritional diseases of the folds (intertriginous areas). ( 26051055 )
2015
28
Acrodermatitis Enteropathica: A Novel SLC39A4 Gene Mutation in a Patient with Normal Zinc Levels. ( 25780817 )
2015
29
Acrodermatitis enteropathica in an infant with normal zinc levels. ( 25566908 )
2015
30
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. ( 26513075 )
2015
31
Acrodermatitis enteropathica in an adult. ( 26244999 )
2015
32
Celiac Disease Presenting With Acquired Acrodermatitis Enteropathica. ( 26465901 )
2015
33
Bullous acrodermatitis enteropathica: case report of a unique clinical presentation and review of the literature. ( 25933075 )
2015
34
Identification of a Novel Mutation in the SLC39A4 Gene in a Case of Acrodermatitis Enteropathica. ( 26351177 )
2015
35
Genetic causes and genea89nutrient interactions in mammalian zinc deficiencies: acrodermatitis enteropathica and transient neonatal zinc deficiency as examples. ( 25468189 )
2015
36
Clinical utility gene card for: acrodermatitis enteropathica - update 2015. ( 26443269 )
2015
37
One recurrent homozygous mutation of SLC39A4 in a girl with acrodermatitis enteropathica from southwestern China. ( 24962159 )
2014
38
Secondary acrodermatitis enteropathica-like lesions in a child with newly diagnosed coeliac disease. ( 25540873 )
2014
39
Cow's Milk Protein Allergy Mimicking Acrodermatitis Enteropathica. ( 24783119 )
2014
40
Images in clinical medicine. Acquired acrodermatitis enteropathica. ( 24988559 )
2014
41
Development of a plasma zinc concentration cutoff to identify individuals with severe zinc deficiency based on results from adults undergoing experimental severe dietary zinc restriction and individuals with acrodermatitis enteropathica. ( 24850624 )
2014
42
Images in emergency medicine. Child with diarrhea and rash. Acrodermatitis enteropathica. ( 24054094 )
2013
43
Acrodermatitis enteropathica-like skin lesions in a neonate. ( 23814231 )
2013
44
Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of acrodermatitis enteropathica. ( 24015258 )
2013
45
Transient symptomatic zinc deficiency resembling acrodermatitis enteropathica in a breast-fed premature infant: case report and brief review of the literature. ( 24442054 )
2013
46
Acrodermatitis enteropathica in three siblings. ( 23442482 )
2013
47
Periorificial dermatitis and erosive inguinal plaques in a 57-year-old woman. Acquired zinc deficiency acrodermatitis enteropathica (ADE). ( 23552816 )
2013
48
Acrodermatitis enteropathica. ( 22486149 )
2012
49
Think zinc deficiency: acquired acrodermatitis enteropathica due to poor diet and common medications. ( 22911205 )
2012
50
Two compound heterozygous novel SLC39A4 mutations in generalized eczematoid acrodermatitis enteropathica. ( 23228939 )
2012

Variations for Enteropathica

Expression for Enteropathica

Search GEO for disease gene expression data for Enteropathica.

Pathways for Enteropathica

Pathways related to Enteropathica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.61 SLC30A4 SLC39A4

GO Terms for Enteropathica

Biological processes related to Enteropathica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to zinc ion GO:0010043 8.96 OTC SLC30A4
2 zinc ion transport GO:0006829 8.62 SLC30A4 SLC39A4

Molecular functions related to Enteropathica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion transmembrane transporter activity GO:0005385 8.62 SLC30A4 SLC39A4

Sources for Enteropathica

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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