Enteropathy-Associated T-Cell Lymphoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

EATL MCID: ENT008 MIFTS: 39	Enteropathy-Associated T-Cell Lymphoma (EATL) Categories: Blood diseases, Cancer diseases, Gastrointestinal diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Enteropathy-Associated T-Cell Lymphoma

MalaCards integrated aliases for Enteropathy-Associated T-Cell Lymphoma:

Name: Enteropathy-Associated T-Cell Lymphoma ⁵³ ⁵⁹ ⁷³

High-Grade Pleomorphic Peripheral T-Cell Lymphoma ⁵³

Enteropathy-Type T-Cell Lymphoma ⁵⁹

Intestinal T-Cell Lymphoma ⁵⁹

Eatcl ⁵³

Eatl ⁵⁹

Ettl ⁵⁹

Characteristics:

Orphanet epidemiological data:

⁵⁹

enteropathy-associated t-cell lymphoma
Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Gastrointestinal diseases Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴ ³³

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Other specified types of T/NK-cell lymphoma

Enteropathy-type (intestinal) T-cell lymphoma

Orphanet: ⁵⁹

Rare gastroenterological diseases

Rare haematological diseases

External Ids:

Orphanet ⁵⁹ ORPHA86880

MESH via Orphanet ⁴⁵ D058527

UMLS via Orphanet ⁷⁴ C0456889

ICD10 via Orphanet ³⁴ C86.2

ICD10 ³³ C86.2

UMLS ⁷³ C0456889

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Summaries for Enteropathy-Associated T-Cell Lymphoma

MalaCards based summary : Enteropathy-Associated T-Cell Lymphoma, also known as high-grade pleomorphic peripheral t-cell lymphoma, is related to lymphoma and celiac disease 1. An important gene associated with Enteropathy-Associated T-Cell Lymphoma is SETD2 (SET Domain Containing 2), and among its related pathways/superpathways are Akt Signaling and G-protein signaling_Regulation of RAC1 activity. The drugs Xalkori and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, small intestine and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷⁶ Enteropathy-associated T-cell lymphoma (EATL), also enteropathy-type T-cell lymphoma (ETTL), is a type... more...

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Related Diseases for Enteropathy-Associated T-Cell Lymphoma

Diseases related to Enteropathy-Associated T-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)

#	Related Disease	Score	Top Affiliating Genes
1	lymphoma	11.1
2	celiac disease 1	10.7
3	refractory celiac disease	10.5
4	b-cell lymphomas	10.2
5	histiocytosis	10.2
6	malignant histiocytosis	10.2
7	autoimmune enteropathy	10.2
8	marginal zone b-cell lymphoma	10.1
9	cauda equina syndrome	10.1
10	composite lymphoma	10.1
11	anemia, autoimmune hemolytic	10.1
12	myocardial infarction	10.1
13	cholangitis, primary sclerosing	10.1
14	hemolytic anemia	10.1
15	hemophagocytic lymphohistiocytosis	10.1
16	peripheral t-cell lymphoma	10.1
17	ulcerative colitis	10.1
18	colitis	10.1
19	jejunoileitis	10.1
20	obstructive jaundice	10.1
21	sclerosing cholangitis	10.1
22	intestinal perforation	10.1
23	restrictive cardiomyopathy	10.1
24	reticulosarcoma	10.1
25	cholangitis	10.1
26	lymphoma, hodgkin, classic	10.1
27	lymphoma, non-hodgkin, familial	10.1
28	spondylocarpotarsal synostosis syndrome	10.0
29	hepatosplenic t-cell lymphoma	10.0
30	anaplastic large cell lymphoma	9.9
31	common variable immunodeficiency	9.9
32	erythema multiforme	9.9
33	lymphangioma	9.9
34	hypereosinophilic syndrome	9.9
35	cavernous lymphangioma	9.9
36	proteasome-associated autoinflammatory syndrome 1	9.8	CCL11 SETD2

Graphical network of the top 20 diseases related to Enteropathy-Associated T-Cell Lymphoma:

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Symptoms & Phenotypes for Enteropathy-Associated T-Cell Lymphoma

MGI Mouse Phenotypes related to Enteropathy-Associated T-Cell Lymphoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.26	CCL11 CD3G ITGAE SETD2
2	immune system	MP:0005387	8.92	CCL11 CD3G ITGAE SETD2

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Drugs & Therapeutics for Enteropathy-Associated T-Cell Lymphoma

FDA approved drugs:

#	Drug Name	Active Ingredient(s) ¹⁸	Company	Approval Date
1	Xalkori ¹⁸ ⁴⁹	CRIZOTINIB	Pfizer	August of 2011
FDA Label: Xalkori Disease/s that Drug Treats:ALK+ non-small cell lung cancer Indications and Usage: ¹⁸ XALKORI is a kinase inhibitor indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplasticlymphoma kinase (ALK)-positive as detected by an FDA-approved test. (1), XALKORI is a kinase inhibitor indicated for the treatment of patients with: * metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test. (1.1) * metastatic NSCLC whose tumors are ROS1-positive. (1.2) DrugBank Targets: ¹⁶ 1. ALK tyrosine kinase receptor;2. Hepatocyte growth factor receptor, ALK tyrosine kinase receptor\|Hepatocyte growth factor receptor Mechanism of Action: ¹⁸ Target: receptor tyrosine kinases, receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), and Recepteur dâOrigine Nantais (RON) Action: inhibitor FDA: Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor(HGFR, c-Met), ROS1 (c-ros), and Recepteur dâOrigine Nantais (RON). Translocations can affect the ALKgene resulting in the expression of oncogenic fusion proteins. The formation of ALK fusion proteins results inactivation and dysregulation of the geneâs expression and signaling which can contribute to increased cellproliferation and survival in tumors expressing these proteins. Crizotinib demonstrated concentration-dependentinhibition of ALK, ROS1, and c-Met phosphorylation in cell-based assays using tumor cell lines anddemonstrated antitumor activity in mice bearing tumor xenografts that expressed EML4- or NPM-ALK fusionproteins or c-Met. , Crizotinib is an inhibitor of receptor tyrosine kinases including ALK, Hepatocyte Growth Factor Receptor (HGFR, c-Met), ROS1 (c-ros), and Recepteur dâOrigine Nantais (RON). Translocations can affect the ALK gene resulting in the expression of oncogenic fusion proteins. The formation of ALK fusion proteins results in activation and dysregulation of the geneâs expression and signaling which can contribute to increased cell proliferation and survival in tumors expressing these proteins. Crizotinib demonstrated concentration-dependent inhibition of ALK, ROS1, and c-Met phosphorylation in cell-based assays using tumor cell lines and demonstrated antitumor activity in mice bearing tumor xenografts that expressed echinoderm microtubule-associated protein-like 4 (EML4)- or nucleophosmin (NPM)-ALK fusion proteins or c-Met.

Drugs for Enteropathy-Associated T-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Cyclophosphamide

Approved, Investigational

Phase 4,Phase 2,Phase 1,Early Phase 1

6055-19-2, 50-18-0

2907

Gemcitabine

Approved

Phase 4,Phase 2

95058-81-4

60750

Vincristine

Approved, Investigational

Phase 4,Phase 2,Phase 1

57-22-7, 2068-78-2

5978

Etoposide

Approved

Phase 4,Phase 2,Phase 1,Early Phase 1

33419-42-0

36462

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4,Early Phase 1

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4,Early Phase 1

1177-87-3

Cisplatin

Approved

Phase 4,Phase 2

15663-27-1

2767 441203 84093

Ifosfamide

Approved

Phase 4,Phase 2,Phase 1,Early Phase 1

3778-73-2

3690

Epirubicin

Approved

Phase 4,Phase 2

56420-45-2

41867

Prednisone

Approved, Vet_approved

Phase 4,Phase 1,Phase 2,Early Phase 1

53-03-2

5865

Methotrexate

Approved

Phase 4,Phase 2,Early Phase 1

59-05-2, 1959-05-2

126941

leucovorin

Approved

Phase 4,Phase 2,Early Phase 1

58-05-9

6006 143

Doxorubicin

Approved, Investigational

Phase 4,Phase 2,Phase 1,Early Phase 1

23214-92-8

31703

Mechlorethamine

Approved, Investigational

Phase 4,Phase 1,Early Phase 1

51-75-2

4033

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Early Phase 1

59-30-3

6037

Doxil

Approved June 1999

Phase 4,Phase 2,Phase 1,Early Phase 1

31703

Pirarubicin

Investigational

Phase 4

72496-41-4

Isophosphamide mustard

Phase 4,Phase 2,Phase 1,Early Phase 1

Hormone Antagonists

Phase 4,Phase 2,Phase 1,Early Phase 1

Anti-Bacterial Agents

Phase 4,Phase 2,Phase 1,Early Phase 1

Antineoplastic Agents, Alkylating

Phase 4,Phase 2,Phase 1,Early Phase 1

Topoisomerase Inhibitors

Phase 4,Phase 2,Phase 1,Early Phase 1

Antibiotics, Antitubercular

Phase 4,Phase 2,Phase 1,Early Phase 1

Immunologic Factors

Phase 4,Phase 2,Phase 1,Early Phase 1

Antineoplastic Agents, Hormonal

Phase 4,Phase 2,Phase 1,Early Phase 1

Antimitotic Agents

Phase 4,Phase 2,Phase 1

Alkylating Agents

Phase 4,Phase 2,Phase 1,Early Phase 1

Hormones

Phase 4,Phase 2,Phase 1,Early Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 2,Phase 1,Early Phase 1

Antineoplastic Agents, Phytogenic

Phase 4,Phase 2,Phase 1,Early Phase 1

Immunosuppressive Agents

Phase 4,Phase 2,Phase 1,Early Phase 1

BB 1101

Phase 4,Early Phase 1

Etoposide phosphate

Phase 4,Phase 2,Phase 1,Early Phase 1

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2,Phase 1,Early Phase 1

Antirheumatic Agents

Phase 4,Phase 2,Phase 1,Early Phase 1

glucocorticoids

Phase 4,Phase 2,Phase 1,Early Phase 1

Folic Acid Antagonists

Phase 4,Phase 2,Early Phase 1

Dermatologic Agents

Phase 4,Phase 2,Phase 1,Early Phase 1

Vitamin B Complex

Phase 4,Phase 2,Early Phase 1

Antimetabolites

Phase 4,Phase 2,Phase 1,Early Phase 1

Folate

Phase 4,Phase 2,Early Phase 1

Antimetabolites, Antineoplastic

Phase 4,Phase 2,Phase 1,Early Phase 1

Vitamin B9

Phase 4,Phase 2,Early Phase 1

Nucleic Acid Synthesis Inhibitors

Phase 4,Phase 2,Early Phase 1

Cytarabine

Approved, Investigational

Phase 2

147-94-4

6253

Methylprednisolone

Approved, Vet_approved

Phase 2

83-43-2

6741

Prednisolone phosphate

Approved, Vet_approved

Phase 2

302-25-0

Prednisolone

Approved, Vet_approved

Phase 2

50-24-8

5755

Melphalan

Approved

Phase 2

148-82-3

4053 460612

Methylprednisolone hemisuccinate

Approved

Phase 2

2921-57-5

Interventional clinical trials:

(show all 22)

#	Name	Status	NCT ID	Phase	Drugs
1	CEOP/IVE/GDP Compared With CEOP as the First-line Therapy for Newly Diagnosed Adult Patients With PTCL	Unknown status	NCT02533700	Phase 4	CEOP/IVE/GDP chemotherapy regimen;CEOP chemotherapy regimen for 6 cycles
2	CTOP/ITE/MTX Compared With CHOP as the First-line Therapy for Newly Diagnosed Young Patients With T Cell Lymphoma	Active, not recruiting	NCT01746992	Phase 4	Cyclophosphamide 750mg/m2;Vincristine 1.4mg/m2;Doxorubicin 50mg/m2;prednisone 60mg/m2;ifosfamide 2000mg/m2;pirarubicin 50mg/m2;pirarubicin 25mg/m2;Etoposide phosphate 100mg/m2;methotrexate 1500mg/m2
3	High-Dose Chemotherapy Given Together With Peripheral Blood Stem Cell Transplant in Treating Patients With Intestinal T-Cell Lymphoma	Unknown status	NCT00669812	Phase 2	carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;melphalan;methotrexate;prednisolone;vincristine sulfate
4	CAR-pNK Cell Immunotherapy in CD7 Positive Leukemia and Lymphoma	Unknown status	NCT02742727	Phase 1, Phase 2
5	Study of Bortezomib and Panobinostat in Treating Patients With Relapsed/Refractory Peripheral T-cell Lymphoma or NK/T-cell Lymphoma	Completed	NCT00901147	Phase 2	panobinostat and bortezomib
6	SAHA + CHOP in Untreated T-cell Non-Hodgkin's Lymphoma	Completed	NCT00787527	Phase 1, Phase 2	Zolinza (vorinostat);Cyclophosphamide;Doxorubicin;Vincristine;Prednisone
7	CHP-BV Followed by Consolidation With High-dose Therapy / ASCT as Frontline Treatment of Patients With EATL Type 1.	Recruiting	NCT03217643	Phase 2	Brentuximab Vedotin
8	Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma	Recruiting	NCT03075553	Phase 2
9	Brentuximab Vedotin and Combination Chemotherapy in Treating Patients With CD30-Positive Peripheral T-cell Lymphoma	Recruiting	NCT03113500	Phase 2	Brentuximab Vedotin;Cyclophosphamide;Doxorubicin;Etoposide;Prednisone
10	A Phase II Study of Single Agent Brentuximab Vedotin in Relapsed/Refractory CD30 Low (<10%) Mature T Cell Lymphoma (TCL)	Recruiting	NCT02588651	Phase 2	Brentuximab vedotin
11	CHOP vs GEM-P in 1st Line Treatment of T-cell Lymphoma, Multicentre Phase II Study	Active, not recruiting	NCT01719835	Phase 2	Cyclophosphamide;Gemcitabine;Doxorubicin;Vincristine;Prednisolone;methylprednisolone;Cisplatin
12	Combination Chemotherapy and Lenalidomide in Treating Patients With Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma	Active, not recruiting	NCT02561273	Phase 1, Phase 2	Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Lenalidomide;Prednisone;Vincristine Sulfate
13	Combination of Vorinostat and Bortezomib in Relapsed or Refractory T-Cell Non-Hodgkin's Lymphoma	Terminated	NCT00810576	Phase 2	Vorinostat;Bortezomib
14	Romidepsin, Ifosfamide, Carboplatin, and Etoposide in Treating Participants With Relapsed or Refractory Peripheral T-Cell Lymphoma	Completed	NCT01590732	Phase 1	Carboplatin;Etoposide;Ifosfamide;Romidepsin
15	Study of MLN8237 in Participants With Advanced Hematological Malignancies	Completed	NCT00697346	Phase 1	Alisertib
16	T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas	Recruiting	NCT03049449	Phase 1	Cyclophosphamide;Fludarabine
17	Everolimus and Bortezomib in Treating Patients With Relapsed or Refractory Lymphoma	Terminated	NCT00671112	Phase 1	Bortezomib;Everolimus
18	Comparison Between Axial- and Lateral-viewing Capsule Endoscopy in Celiac Disease	Recruiting	NCT03095573	Not Applicable
19	MAgnetic Resonance Imaging in COeliac Disease	Recruiting	NCT02551289
20	Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency	Recruiting	NCT01787409	Not Applicable
21	Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma	Active, not recruiting	NCT02652715	Not Applicable
22	INDUCTION CHEMO-IMMUNOTHERAPY FOLLOWED BY CONSOLIDATION WITH REDUCED TOXICITY CONDITIONING AND ALLOGENEIC STEM CELL TRANSPLANT IN ADVANCED STAGE MATURE NON-ANAPLASTIC T-CELL OR NK LYMPHOMA/LEUKEMIA IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS	Not yet recruiting	NCT03719105	Early Phase 1	Methotrexate, ifosfamide, dexamethasone, etoposide, pegasparagase,;pralatraxate, cyclophosphamide, doxorubicin, prednisone, brentuximab vedotin

Search NIH Clinical Center for Enteropathy-Associated T-Cell Lymphoma

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Genetic Tests for Enteropathy-Associated T-Cell Lymphoma

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Anatomical Context for Enteropathy-Associated T-Cell Lymphoma

MalaCards organs/tissues related to Enteropathy-Associated T-Cell Lymphoma:

⁴¹

T Cells, Small Intestine, Lung, Testes, Colon, B Cells, Lymph Node

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Publications for Enteropathy-Associated T-Cell Lymphoma

Articles related to Enteropathy-Associated T-Cell Lymphoma:

(show top 50) (show all 136)

#	Title	Authors	Year
1	Type II enteropathy-associated t-cell lymphoma: A case report and literature review. ( 29888733 )	Zhao L....Zhang Y.	2018
2	Pathogenesis of Enteropathy-Associated T Cell Lymphoma. ( 29943210 )	Chander U....Bhagat G.	2018
3	Coexpression of CD3 and CD20 in Canine Enteropathy-Associated T-cell Lymphoma. ( 29343197 )		2018
4	Intestinal T-cell lymphoma with enteropathy-associated T-cell lymphoma-like features arising in the setting of adult autoimmune enteropathy. ( 29446107 )		2018
5	An unexpected deterrent in diagnosing refractory celiac disease and enteropathy-associated T-cell lymphoma: a gluten-free diet. ( 30181834 )	Hussain N...Lynch T	2018
6	Perforation of the small intestine caused by enteropathy-associated T cell lymphoma. ( 30302434 )	Kabul S...?zt?rk E	2018
7	Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2. ( 28424246 )	Moffitt A.B....Dave S.S.	2017
8	Type II Enteropathy-Associated T-cell Lymphoma: A Rare Report from Iran. ( 28316767 )	Nozari N.	2017
9	Enteropathy-associated T-cell lymphoma presenting as cutaneous deposits. ( 27766624 )	Webster A....Miall F.	2017
10	A Case of Type II Enteropathy-Associated T-Cell Lymphoma in a Patient With Ulcerative Colitis. ( 28572650 )		2017
11	Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations. ( 27600764 )	Roberti A....de Leval L.	2016
12	High myeloid-derived suppressor cell frequencies in the duodenum are associated with enteropathy associated T-cell lymphoma and its precursor lesions. ( 27341082 )	Bontkes H.J....de Gruijl T.D.	2016
13	Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. ( 27772962 )	Tomita S....Nakamura N.	2016
14	Type I enteropathy-associated T-cell lymphoma in the colon of a 29-year-old patient and a brief literature review. ( 26955284 )	Zhang J.C....Zhang F.X.	2016
15	Enteropathy-associated T-cell lymphoma: An extremely rare cause of chronic diarrhoea. ( 27326953 )		2016
16	Eosinophil-Rich Acute Febrile Neutrophilic Dermatosis in a Patient With Enteropathy-Associated T-cell Lymphoma, Type 1. ( 27097333 )		2016
17	Enteropathy-Associated T-Cell Lymphoma. ( 27900603 )		2016
18	Establishment of a Patient-Derived Xenograft of Canine Enteropathy-Associated T-Cell Lymphoma, Large Cell Type. ( 28011041 )		2016
19	Enteropathy-associated T-cell lymphoma in the US: higher incidence and poorer survival among Asians. ( 26104061 )	Karanam P.K....Go R.S.	2015
20	Cross Lineage Rearrangement in Feline Enteropathy-Associated T-cell Lymphoma. ( 26215761 )	Andrews C....Kiupel M.	2015
21	A new and validated clinical prognostic model (EPI) for Enteropathy Associated T-cell Lymphoma. ( 25779949 )	de Baaij L.R....Cillessen S.A.	2015
22	Enteropathy-associated T-cell lymphoma: improving treatment strategies. ( 25925928 )	Nijeboer P....Visser O.	2015
23	Enteropathy-associated T-cell lymphoma: involvement of the gastrointestinal tract from the duodenum to the rectum. ( 26115398 )	Demir Y....Bayram A.^.	2015
24	Primary Enteropathy-Associated T-Cell Lymphoma Type 2: An Emerging Entity? ( 26068772 )	Grigg-Gutierrez N.M....Toro D.H.	2015
25	Enteropathy-associated T-cell lymphoma in childhood: a case report and review of the literature. ( 25629982 )	Chisini M....Testi A.M.	2015
26	Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan. ( 26226842 )		2015
27	Discordant and metachronous Non-Hodgkin's lymphomas: Enteropathy-associated T-cell lymphoma, Type II with aberrant expression of CD4 presenting several years after a mucosa-associated lymphoid tissue type B-cell lymphoma. ( 26549098 )		2015
28	A rare but potentially fatal cause of diarrhoea and weight loss: enteropathy-associated T-cell lymphoma. ( 25568262 )		2015
29	Endoscopic Findings of Enteropathy-Associated T-Cell Lymphoma Type II: A Case Series. ( 26260757 )		2015
30	Treatment response in Enteropathy Associated T-cell Lymphoma; survival in a large multicenter cohort. ( 25716069 )		2015
31	An unusual case of enteropathy-associated T-cell lymphoma with CD20 positivity. ( 25308040 )	Misra D.S....Malhotra V.	2014
32	Enteropathy-associated T-cell lymphoma, type II (monomorphic variant). ( 24822244 )	Raza A....Zu Y.	2014
33	Enteropathy associated T cell lymphoma-monomorphic variant, presenting as bilateral ovarian masses. ( 24943780 )	Jacob P.M....Suchetha S.	2014
34	Enteropathy-associated T-cell lymphoma presenting with gastrointestinal tract symptoms: A report of two cases and review of diagnostic challenges and clinicopathological correlation. ( 24959225 )	Jiao G....Wang B.	2014
35	Detailed clinicopathological characteristics and possible lymphomagenesis of type II intestinal enteropathy-associated T-cell lymphoma in Japan. ( 24746558 )	Kikuma K....Takeshita M.	2014
36	Enteropathy-associated T cell lymphoma as a complication of silent celiac disease. ( 25568762 )	Brito M.D....Mariz J.	2014
37	Enteropathy associated T cell lymphoma - a case report of an uncommon extranodal T cell lymphoma. ( 25478355 )		2014
38	Successful Diagnosis of Type II Enteropathy-associated T-cell Lymphoma Using Flow Cytometry and the Cell Block Technique of Celomic Fluid Manifesting as Massive Pyoid Ascites that Could Not Be Diagnosed via Emergency Laparotomy. ( 24429453 )		2014
39	Enteropathy associated T-cell lymphoma presenting with multiple episodes of small bowel haemorrhage and perforation. ( 24876396 )		2014
40	Profile of CD103 Expression in T-cell Neoplasms: Immunoreactivity Is Not Restricted to Enteropathy-associated T-cell Lymphoma. ( 25025448 )		2014
41	A Case of Type II Enteropathy-Associated T-Cell Lymphoma with Epstein-Barr Virus Positivity. ( 25588633 )	Song MJ...Huh J	2014
42	Hemophagocytic Lymphohistiocytic Syndrome and Enteropathy-Associated T-cell Lymphoma in a Patient with Refractory Celiac Disease. ( 26157854 )	Lu L...Puglia M	2014
43	Classic versus type II enteropathy-associated T-cell lymphoma: diagnostic considerations. ( 23991736 )	Arps D.P....Smith L.B.	2013
44	Hemophagocytic lymphohistiocytosis: an uncommon presentation of enteropathy-associated T-cell lymphoma. ( 23530098 )	Varghese D....Benjamin S.	2013
45	Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT. ( 23361910 )	Jantunen E....Dreger P.	2013
46	Challenges in the diagnosis of enteropathy-associated T cell lymphoma. ( 23964351 )	D'Souza P.M....Teshima C.W.	2013
47	Obscure gastrointestinal bleeding and video capsule retention due to enteropathy-associated T-cell lymphoma. ( 24719605 )	Ho H.C....Hass D.J.	2013
48	A case of colon perforation due to enteropathy-associated T-cell lymphoma. ( 23555174 )		2013
49	Clinically undiagnosed enteropathy associated T-cell lymphoma type II presenting with prolonged lower gastrointestinal tract symptoms: report of an autopsy case and review of diagnostic challenges and clinicopathological correlation. ( 23450273 )		2013
50	Brentuximab in the treatment of CD30-positive enteropathy-associated T-cell lymphoma. ( 23411380 )		2013

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Genes for Enteropathy-Associated T-Cell Lymphoma

Genes related to Enteropathy-Associated T-Cell Lymphoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SETD2	SET Domain Containing 2	Protein Coding	17.53	GeneCards inferred via : Publications (show sections)
2	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	17.18	GeneCards inferred via : Publications (show sections)
3	CD3G	CD3g Molecule	Protein Coding	17.18	GeneCards inferred via : Publications (show sections)
4	ITGAE	Integrin Subunit Alpha E	Protein Coding	17.18	GeneCards inferred via : Publications (show sections)

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Variations for Enteropathy-Associated T-Cell Lymphoma

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Expression for Enteropathy-Associated T-Cell Lymphoma

Search GEO for disease gene expression data for Enteropathy-Associated T-Cell Lymphoma.

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Pathways for Enteropathy-Associated T-Cell Lymphoma

Pathways related to Enteropathy-Associated T-Cell Lymphoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	12.48	CCL11 CD3G ITGAE
2	G-protein signaling_Regulation of RAC1 activity ²²	10.64	CD3G ITGAE
3	Reelin Pathway (Cajal-Retzius cells) ⁶⁴	10.63	CD3G ITGAE

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GO Terms for Enteropathy-Associated T-Cell Lymphoma

Cellular components related to Enteropathy-Associated T-Cell Lymphoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	8.62	CD3G ITGAE

Sources

Sources for Enteropathy-Associated T-Cell Lymphoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Enteropathy-Associated T-Cell Lymphoma (EATL)

Aliases & Classifications for Enteropathy-Associated T-Cell Lymphoma

MalaCards integrated aliases for Enteropathy-Associated T-Cell Lymphoma:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for Enteropathy-Associated T-Cell Lymphoma

Related Diseases for Enteropathy-Associated T-Cell Lymphoma

Diseases related to Enteropathy-Associated T-Cell Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Enteropathy-Associated T-Cell Lymphoma:

Symptoms & Phenotypes for Enteropathy-Associated T-Cell Lymphoma

MGI Mouse Phenotypes related to Enteropathy-Associated T-Cell Lymphoma:

Drugs & Therapeutics for Enteropathy-Associated T-Cell Lymphoma

FDA approved drugs:

Drugs for Enteropathy-Associated T-Cell Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Enteropathy-Associated T-Cell Lymphoma

Anatomical Context for Enteropathy-Associated T-Cell Lymphoma

MalaCards organs/tissues related to Enteropathy-Associated T-Cell Lymphoma:

Publications for Enteropathy-Associated T-Cell Lymphoma

Articles related to Enteropathy-Associated T-Cell Lymphoma:

Genes for Enteropathy-Associated T-Cell Lymphoma

Genes related to Enteropathy-Associated T-Cell Lymphoma (0 elite genes):

Variations for Enteropathy-Associated T-Cell Lymphoma

Expression for Enteropathy-Associated T-Cell Lymphoma

Pathways for Enteropathy-Associated T-Cell Lymphoma

Pathways related to Enteropathy-Associated T-Cell Lymphoma according to GeneCards Suite gene sharing:

GO Terms for Enteropathy-Associated T-Cell Lymphoma

Cellular components related to Enteropathy-Associated T-Cell Lymphoma according to GeneCards Suite gene sharing:

Sources for Enteropathy-Associated T-Cell Lymphoma