MCID: ENT004
MIFTS: 43

Enthesopathy

Categories: Bone diseases, Muscle diseases

Aliases & Classifications for Enthesopathy

Summaries for Enthesopathy

Disease Ontology : 12 A connective tissue disease characterized by damage of tissues located in the entheses, the site of insertion of tendons or ligaments into bones or joint capsules, with symptoms of pain, swelling and inflammation.

MalaCards based summary : Enthesopathy, also known as rheumatism, is related to tendinitis and hypophosphatemic rickets, x-linked dominant, and has symptoms including myalgia, joint symptom and musculoskeletal symptom. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase Homolog X-Linked). The drugs Etanercept and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and kidney, and related phenotype is growth/size/body region.

Wikipedia : 76 In medicine, an enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a... more...

Related Diseases for Enthesopathy

Diseases related to Enthesopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 tendinitis 30.3 MRAP PHB2
2 hypophosphatemic rickets, x-linked dominant 30.2 DMP1 FGF23 PHEX
3 hypophosphatemia 30.2 DMP1 FGF23 PHEX
4 juvenile ankylosing spondylitis 29.8 MEFV MRAP PHB2
5 bursitis 29.8 MRAP PHB2
6 rickets 29.7 DMP1 FGF23 PHEX
7 hypophosphatemic rickets, x-linked recessive 29.7 DMP1 FGF23 PHEX
8 diffuse idiopathic skeletal hyperostosis 11.4
9 epicondylitis 10.7
10 arthritis 10.4
11 psoriasis 10.4
12 arthropathy 10.3
13 spondyloarthropathy 1 10.3
14 spondylitis 10.3
15 psoriatic arthritis 10.3
16 osteoarthritis 10.2
17 hyperostosis 10.2
18 periarthritis 10.2
19 opsismodysplasia 10.2 FGF23 PHEX
20 familial tumoral calcinosis 10.1 FGF23 PHEX
21 calcinosis 10.1 FGF23 PHEX
22 hypophosphatemic rickets, autosomal dominant 10.1 FGF23 PHEX
23 arterial calcification of infancy 10.1 FGF23 PHEX
24 familial mediterranean fever 10.1
25 tendinopathy 10.1
26 spondyloarthropathy 10.1
27 mineral metabolism disease 10.1 FGF23 PHEX
28 iris disease 10.1 MRAP PHEX
29 raine syndrome 10.1 DMP1 FGF23
30 byssinosis 10.1 MEFV MRAP
31 hyperphosphatemia 10.1 FGF23 PHEX
32 balanitis 10.1 MRAP PHB2
33 iritis 10.1 MRAP PHB2
34 urethritis 10.0 MRAP PHB2
35 bone remodeling disease 10.0 FGF23 PHEX
36 uveal disease 10.0 MRAP PHEX
37 palindromic rheumatism 10.0 MEFV MRAP
38 transient arthritis 10.0 MRAP PHB2
39 patellar tendinitis 10.0
40 achilles bursitis 10.0
41 heel spur 10.0
42 urethral syndrome 10.0 MRAP PHB2
43 oncogenic osteomalacia 10.0 DMP1 FGF23 PHEX
44 osteomalacia 10.0 DMP1 FGF23 PHEX
45 autosomal recessive hypophosphatemic rickets 10.0 DMP1 FGF23 PHEX
46 phosphorus metabolism disease 10.0 DMP1 FGF23 PHEX
47 hypophosphatemic rickets with hypercalciuria, hereditary 10.0 DMP1 FGF23 PHEX
48 gout 10.0
49 synovitis 10.0
50 nail disease 10.0

Comorbidity relations with Enthesopathy via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Enthesopathy:



Diseases related to Enthesopathy

Symptoms & Phenotypes for Enthesopathy

UMLS symptoms related to Enthesopathy:


myalgia, joint symptom, musculoskeletal symptom

MGI Mouse Phenotypes related to Enthesopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 DMP1 FGF23 MEFV PHB2 PHEX SERPINI2

Drugs & Therapeutics for Enthesopathy

Drugs for Enthesopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Acetaminophen Approved Phase 4 103-90-2 1983
5 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
6 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
7 Analgesics Phase 4,Phase 3
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
9 Immunosuppressive Agents Phase 4,Phase 3
10 Analgesics, Non-Narcotic Phase 4,Phase 3
11 Gastrointestinal Agents Phase 4
12 Immunologic Factors Phase 4,Phase 3
13 Antirheumatic Agents Phase 4,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Antipyretics Phase 4
16 Analgesics, Opioid Phase 4
17 Narcotics Phase 4
18 Cyclooxygenase Inhibitors Phase 4
19
Lidocaine Approved, Vet_approved Phase 2, Phase 3,Phase 1 137-58-6 3676
20
Apremilast Approved, Investigational Phase 3 608141-41-9 11561674
21 Anesthetics, Local Phase 2, Phase 3,Phase 1
22 Diuretics, Potassium Sparing Phase 2, Phase 3,Phase 1
23 Anti-Arrhythmia Agents Phase 2, Phase 3,Phase 1
24 Sodium Channel Blockers Phase 2, Phase 3,Phase 1
25 Anesthetics Phase 2, Phase 3,Phase 1
26 Anti-Infective Agents Phase 3
27 Angiogenesis Modulating Agents Phase 3
28 Anti-Bacterial Agents Phase 3
29 Angiogenesis Inhibitors Phase 3
30
Iodine Approved, Investigational Not Applicable 7553-56-2 807
31
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
32 cadexomer iodine Not Applicable
33 Performance-Enhancing Substances
34 Hormones
35 Mitogens
36
Boswellic acid Not Applicable 631-69-6 168928

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
2 A Study to Evaluate the Impact of Apremilast (CC-10004) on MRI Outcomes in Subjects With Psoriatic Arthritis Not yet recruiting NCT03783026 Phase 4 CC-10004
3 An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Terminated NCT00766402 Phase 4 Tramadol /acetaminophen;Diclofenac
4 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
5 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA) Completed NCT01307423 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo
6 PALACE 3: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis Completed NCT01212770 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo
7 PALACE 2: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis Completed NCT01212757 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo + 20 mg Apremilast;Placebo + 30 mg Apremilast
8 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis Completed NCT01172938 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo + 20 mg Apremilast;Placebo + 30 mg Apremilast
9 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
10 Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis Unknown status NCT02962271
11 Distal Erosions and Nail Psoriasis Unknown status NCT02813720
12 Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Nail Psoriasis Completed NCT03757364 Methotrexate
13 Comparison of the Effect of Radial Shock Wave, Ultrasound-guided Needle Puncture, and Combination of Both in the Treatment of Calcific Tendinitis of the Shoulder Completed NCT02677103 Not Applicable
14 Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections Completed NCT01200875
15 Characterisation of Adult-Onset Hypophosphatasia Recruiting NCT02796885
16 Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma Recruiting NCT01406821 Not Applicable
17 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716 Not Applicable
18 Clinical Trial to Evaluate the Effects of a Nutraceutical in Patients Affected by Knee Osteoarthritis Not yet recruiting NCT03612986 Not Applicable

Search NIH Clinical Center for Enthesopathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: enthesopathy

Genetic Tests for Enthesopathy

Anatomical Context for Enthesopathy

MalaCards organs/tissues related to Enthesopathy:

41
Bone, Skin, Kidney, Heart, Testes, Thyroid, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Enthesopathy:

19
The Entheses

Publications for Enthesopathy

Articles related to Enthesopathy:

(show top 50) (show all 1004)
# Title Authors Year
1
Psoriasis and the risk of foot and ankle tendinopathy or enthesopathy in the absence of psoriatic arthritis: a population-based study. ( 29862046 )
2018
2
Aberrant TGF-I^ activation in bone tendon insertion induces enthesopathy-like disease. ( 29355842 )
2018
3
Subclinical enthesopathy of extensor digitorum tendon is highly prevalent and associated with clinical and ultrasound alterations of the adjacent fingernails in patients with psoriatic disease. ( 29706002 )
2018
4
Management of Psoriatic Arthritis: Turkish League Against Rheumatism (TLAR) Expert Opinions. ( 30207576 )
2018
5
Ultrasound-Guided Prolotherapy for Acromial Enthesopathy and Acromioclavicular Joint Arthropathy: A Single-Arm Prospective Study. ( 30171616 )
2018
6
Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island. ( 29486812 )
2018
7
Post-chikungunya chronic inflammatory rheumatism: Follow-up of cases after 1 year of infection in Tolima, Colombia. ( 29203304 )
2018
8
Correction: 2016 American college of rheumatology/European league against rheumatism criteria for minimal moderate, and major clinical response in juvenile dermatomyositis. ( 29530915 )
2018
9
Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets. ( 30002128 )
2018
10
Comparative Efficacy and Safety of Nonsurgical Treatment Options for Enthesopathy of the Extensor Carpi Radialis Brevis: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials. ( 30380334 )
2018
11
Tubulointerstitial Nephritis and Uveitis Syndrome with unilateral enthesopathy of the knee joint. ( 30419574 )
2018
12
Regression of peripheral subclinical enthesopathy in therapy-naïve patients treated with Ustekinumab for moderate-to-severe chronic plaque psoriasis. ( 30468001 )
2018
13
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2018
14
Risk of autoimmune rheumatic diseases in patients with palindromic rheumatism: A nationwide, population-based, cohort study. ( 30048527 )
2018
15
Identification of a distinct imaging phenotype may improve the management of palindromic rheumatism. ( 30297331 )
2018
16
Ultrasound findings in palindromic rheumatism. ( 30552178 )
2018
17
Performance of the 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies in clinical practice. ( 29237619 )
2018
18
Response to: 'Performance of the 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies in clinical practice' by Hočevar et al. ( 29317406 )
2018
19
Correction: European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. ( 30097512 )
2018
20
The performance of the European League Against Rheumatism/American College of Rheumatology idiopathic inflammatory myopathies classification criteria in an expert-defined 10 year incident cohort. ( 30496561 )
2018
21
Do the European League Against Rheumatism (EULAR) Sjögren's syndrome outcome measures correlate with impaired quality of life, fatigue, anxiety and depression in primary Sjögren's syndrome? ( 30002701 )
2018
22
Application of the international league against rheumatism classification criteria for systemic juvenile idiopathic arthritis as a prognostic factor in patients with adults-onset Still's disease. ( 29370863 )
2018
23
Common language description of the term rheumatic and musculoskeletal diseases (RMDs) for use in communication with the lay public, healthcare providers and other stakeholders endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). ( 29525777 )
2018
24
Common Language Description of the Term Rheumatic and Musculoskeletal Diseases (RMDs) for Use in Communication With the Lay Public, Healthcare Providers, and Other Stakeholders Endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). ( 29532625 )
2018
25
2017 update of the Turkish League Against Rheumatism (TLAR) evidence-based recommendations for the management of knee osteoarthritis. ( 29777340 )
2018
26
Homologies and heterogeneity between Rheumatology Congresses: Mexican, American College of Rheumatology and European League Against Rheumatism. ( 29891264 )
2018
27
Turkish League Against Rheumatism Consensus Report: Recommendations For Management of Axial Spondyloarthritis. ( 29900976 )
2018
28
Treatment of chronic inflammatory rheumatism by biotherapy in Gabon : eligibility and follow-up of the first 8 patients in sub-Saharan Africa. ( 29997080 )
2018
29
Enthesopathy in rheumatoid arthritis and spondyloarthritis: An ultrasound study. ( 29233691 )
2017
30
Plantar fascia enthesopathy is highly prevalent in diabetic patients without peripheral neuropathy and correlates with retinopathy and impaired kidney function. ( 28358891 )
2017
31
Intratissue percutaneous electolysis combined with active physical therapy for the treatment of adductor longus enthesopathy-related groin pain: a randomized trial. ( 28116876 )
2017
32
Ultrasonographic Enthesopathy and Disease Activity in Psoriatic Arthritis. ( 28932308 )
2017
33
Clinical and ultrasonographic enthesopathy in inflammatory rheumatic diseases : Is MASEI or only calcaneal enthesitis sufficient? ( 29116386 )
2017
34
Styloid Process Elongation on Cervical Spine Computed Tomography is Associated with the Enthesopathy-Related Diseases of Ankylosing Spondylitis and Diffuse Idiopathic Skeletal Hyperostosis. ( 29185278 )
2017
35
Presence of enthesopathy in patients with primary Sjogren's syndrome: ultrasonographic study of a local cohort. ( 28646319 )
2017
36
X-linked hypophosphatemia with enthesopathy. ( 28784895 )
2017
37
Subclinical enthesopathy in patients with psoriasis and its association with other disease parameters: a power Doppler ultrasonographic study. ( 28293449 )
2017
38
Would be IL-6 a missing link between chronic inflammatory rheumatism and depression after chikungunya infection? ( 28550401 )
2017
39
Impaired quality of life after chikungunya virus infection: a 12-month follow-up study of its chronic inflammatory rheumatism in La Virginia, Risaralda, Colombia. ( 28828632 )
2017
40
Letter to the Editor: Chikungunya Virus Infection-An Update on Chronic Rheumatism in Latin America. ( 28178441 )
2017
41
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28382778 )
2017
42
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28385804 )
2017
43
Performance of the 2015 American College of Rheumatology/European League Against Rheumatism gout classification criteria in Thai patients. ( 28349197 )
2017
44
What can palindromic rheumatism tell us? ( 29221602 )
2017
45
2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. ( 29079590 )
2017
46
2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups. ( 29106061 )
2017
47
2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. ( 27789466 )
2017
48
American College of Rheumatology/European League Against Rheumatism Sjögren's Syndrome Classification Criteria May Not Be Adequate for Extraglandular Disease and Necessitate Defining "Seronegative Sjögren's Syndrome": Comment on the Article by Shiboski et al. ( 28245349 )
2017
49
Evidence-based recommendations for the diagnosis and management of rheumatoid arthritis for non-rheumatologists: Integrating systematic literature research and expert opinion of the Thai Rheumatism Association. ( 27452207 )
2017
50
Routine Assessment of Patient Index Data 3 and the American College of Rheumatology/European League Against Rheumatism Provisional Remission Definitions as Predictors of Radiographic Outcome in a Rheumatoid Arthritis Clinical Trial With Tocilizumab. ( 27564431 )
2017

Variations for Enthesopathy

Expression for Enthesopathy

Search GEO for disease gene expression data for Enthesopathy.

Pathways for Enthesopathy

GO Terms for Enthesopathy

Biological processes related to Enthesopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 9.26 DMP1 PHEX
2 cellular response to vitamin D GO:0071305 9.16 FGF23 PHEX
3 cellular response to parathyroid hormone stimulus GO:0071374 8.96 FGF23 PHEX
4 response to sodium phosphate GO:1904383 8.62 FGF23 PHEX

Sources for Enthesopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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