MCID: ENT004
MIFTS: 44

Enthesopathy

Categories: Bone diseases, Muscle diseases

Aliases & Classifications for Enthesopathy

Summaries for Enthesopathy

Disease Ontology : 12 A connective tissue disease characterized by damage of tissues located in the entheses, the site of insertion of tendons or ligaments into bones or joint capsules, with symptoms of pain, swelling and inflammation.

MalaCards based summary : Enthesopathy, also known as rheumatism, is related to tendinitis and hypophosphatemic rickets, x-linked dominant, and has symptoms including myalgia, joint symptom and musculoskeletal symptom. An important gene associated with Enthesopathy is PHEX (Phosphate Regulating Endopeptidase Homolog X-Linked). The drugs Etanercept and Apremilast have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and testes, and related phenotype is growth/size/body region.

Wikipedia : 77 An enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a bone. This... more...

Related Diseases for Enthesopathy

Diseases related to Enthesopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 tendinitis 31.3 MRAP PHB2
2 hypophosphatemic rickets, x-linked dominant 30.2 DMP1 FGF23 PHEX
3 hypophosphatemia 30.2 DMP1 FGF23 PHEX
4 bursitis 30.0 MRAP PHB2
5 juvenile ankylosing spondylitis 29.8 MEFV MRAP PHB2
6 rickets 29.7 DMP1 FGF23 PHEX
7 hypophosphatemic rickets, x-linked recessive 29.7 DMP1 FGF23 PHEX
8 diffuse idiopathic skeletal hyperostosis 11.5
9 epicondylitis 10.7
10 psoriasis 10.4
11 arthritis 10.4
12 joint disorders 10.4
13 arthropathy 10.4
14 spondyloarthropathy 1 10.3
15 spondylitis 10.3
16 psoriatic arthritis 10.3
17 osteoarthritis 10.3
18 hyperostosis 10.2
19 opsismodysplasia 10.2 FGF23 PHEX
20 familial tumoral calcinosis 10.2 FGF23 PHEX
21 calcinosis 10.2 FGF23 PHEX
22 periarthritis 10.2
23 hypophosphatemic rickets, autosomal dominant 10.2 FGF23 PHEX
24 arterial calcification of infancy 10.2 FGF23 PHEX
25 spondyloarthropathy 10.2
26 familial mediterranean fever 10.1
27 tendinopathy 10.1
28 pustulosis of palm and sole 10.1
29 mineral metabolism disease 10.1 FGF23 PHEX
30 iris disease 10.1 MRAP PHEX
31 raine syndrome 10.1 DMP1 FGF23
32 byssinosis 10.1 MEFV MRAP
33 hyperphosphatemia 10.1 FGF23 PHEX
34 balanitis 10.1 MRAP PHB2
35 iritis 10.1 MRAP PHB2
36 urethritis 10.1 MRAP PHB2
37 bone remodeling disease 10.1 FGF23 PHEX
38 uveal disease 10.1 MRAP PHEX
39 palindromic rheumatism 10.1 MEFV MRAP
40 patellar tendinitis 10.1
41 achilles bursitis 10.1
42 heel spur 10.1
43 transient arthritis 10.0 MRAP PHB2
44 urethral syndrome 10.0 MRAP PHB2
45 gout 10.0
46 rheumatic disease 10.0
47 nail disease 10.0
48 fasciitis 10.0
49 plantar fasciitis 10.0
50 spondylarthropathy 10.0

Comorbidity relations with Enthesopathy via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Enthesopathy:



Diseases related to Enthesopathy

Symptoms & Phenotypes for Enthesopathy

UMLS symptoms related to Enthesopathy:


myalgia, joint symptom, musculoskeletal symptom

MGI Mouse Phenotypes related to Enthesopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 DMP1 FGF23 MEFV PHB2 PHEX SERPINI2

Drugs & Therapeutics for Enthesopathy

Drugs for Enthesopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2
Apremilast Approved, Investigational Phase 4,Phase 3 608141-41-9 11561674
3
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
4
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
5
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
6
Acetaminophen Approved Phase 4 103-90-2 1983
7 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
8 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1
9 Antirheumatic Agents Phase 4,Phase 3
10 Analgesics, Non-Narcotic Phase 4,Phase 3
11 Immunologic Factors Phase 4,Phase 3
12 Analgesics Phase 4,Phase 3
13 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
14 Immunosuppressive Agents Phase 4,Phase 3
15 Gastrointestinal Agents Phase 4
16 Anti-Inflammatory Agents Phase 4,Phase 3
17 Anti-Infective Agents Phase 4,Phase 3
18 Angiogenesis Inhibitors Phase 4,Phase 3
19 Angiogenesis Modulating Agents Phase 4,Phase 3
20 Anti-Bacterial Agents Phase 4,Phase 3
21 Antipyretics Phase 4
22 Analgesics, Opioid Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Narcotics Phase 4
25
Lidocaine Approved, Vet_approved Phase 2, Phase 3,Phase 1 137-58-6 3676
26
Adalimumab Approved Phase 3 331731-18-1 16219006
27 Anesthetics Phase 2, Phase 3,Phase 1
28 Sodium Channel Blockers Phase 2, Phase 3,Phase 1
29 Anesthetics, Local Phase 2, Phase 3,Phase 1
30 Anti-Arrhythmia Agents Phase 2, Phase 3,Phase 1
31 Diuretics, Potassium Sparing Phase 2, Phase 3,Phase 1
32 Pharmaceutical Solutions Phase 3
33 Antibodies, Monoclonal Phase 3
34 Immunoglobulins Phase 3
35 Antibodies Phase 3
36
leucovorin Approved 58-05-9 143 6006
37
Iodine Approved, Investigational Not Applicable 7553-56-2 807
38
Certolizumab pegol Approved 428863-50-7
39
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
40
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
41 Nucleic Acid Synthesis Inhibitors
42 Dermatologic Agents
43 Folate
44 Vitamin B9
45 Antimetabolites, Antineoplastic
46 Folic Acid Antagonists
47 Vitamin B Complex
48 Antimetabolites
49 cadexomer iodine Not Applicable
50 Hormones

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 A Study of the Use of the Madrid Ultrasound Scoring System in the Treatment of Anti-TNF Blocker to Peripheral Tendonitis in Patients With Spondyloarthritis Completed NCT02960035 Phase 4 etanercept;etanercept (half dose);placebo
2 Study Evaluating Etanercept for the Treatment of Refractory Heel Enthesitis in Spondylarthropathy Completed NCT00420303 Phase 4 Etanercept
3 A Study to Evaluate the Impact of Apremilast (CC-10004) on MRI Outcomes in Subjects With Psoriatic Arthritis Recruiting NCT03783026 Phase 4 CC-10004
4 An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs) Terminated NCT00766402 Phase 4 Tramadol /acetaminophen;Diclofenac
5 Treatment for Achilles Tendinopathy Unknown status NCT00835939 Phase 2, Phase 3 25% Dextrose and 1% Lidocaine;Lidocaine
6 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis (PsA) Completed NCT01307423 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo
7 A Study of the Efficacy and Safety of Adalimumab in Pediatric Subjects With Enthesitis Related Arthritis Completed NCT01166282 Phase 3
8 PALACE 3: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis Completed NCT01212770 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo
9 PALACE 2: Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis Completed NCT01212757 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo + 20 mg Apremilast;Placebo + 30 mg Apremilast
10 Efficacy and Safety Study of Apremilast to Treat Active Psoriatic Arthritis Completed NCT01172938 Phase 3 Apremilast 20mg;Apremilast 30mg;Placebo + 20 mg Apremilast;Placebo + 30 mg Apremilast
11 Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH Recruiting NCT03920072 Phase 3 Burosumab
12 Study of Efficacy and Safety of Secukinumab in Psoriatic Arthritis and Axial Spondyloarthritis Patients With Active Enthesitis Including One Achilles Tendon Site Active, not recruiting NCT02771210 Phase 3 AIN457/Secukinumab Placebo
13 An Extension Study of Subcutaneous Secukinumab in Patients With Juvenile Psoriatic Arthritis (JPsA) and Enthesitis Related Arthritis (ERA) Not yet recruiting NCT03769168 Phase 3 AIN457
14 Effectiveness of Dextrose Injection for Osgood-Schlatter Disease Completed NCT01300754 Phase 1, Phase 2
15 Comparation of Ultrasonic Imaging of Enthesopathy in Patients With Psoriatic Arthritis and Psoriasis Unknown status NCT02962271
16 Distal Erosions and Nail Psoriasis Unknown status NCT02813720
17 Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Nail Psoriasis Completed NCT03757364 Methotrexate
18 Comparison of the Effect of Radial Shock Wave, Ultrasound-guided Needle Puncture, and Combination of Both in the Treatment of Calcific Tendinitis of the Shoulder Completed NCT02677103 Not Applicable
19 Features and Outcomes of Patients With Reactive Arthritis Completed NCT03926429
20 Treatment of Acute and Chronic Ligament and Tendon Injuries With Platelet Rich Plasma Completed NCT01406821 Not Applicable
21 Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections Completed NCT01200875
22 Characterisation of Adult-Onset Hypophosphatasia Recruiting NCT02796885
23 Ultrasound Enthesitis Response in Psoriatic Arthritis Recruiting NCT03955861
24 Effects of Pilates Training on Respiratory Muscle Strenght in Patients With Ankylosing Spondylitis Recruiting NCT03904953 Not Applicable
25 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716 Not Applicable
26 Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean Fever Not yet recruiting NCT03917277 Not Applicable
27 Yoga Versus Home Exercise Program in Children With Enthesitis Related Arthritis Not yet recruiting NCT03858504 Not Applicable
28 Clinical Trial to Evaluate the Effects of a Nutraceutical in Patients Affected by Knee Osteoarthritis Not yet recruiting NCT03612986 Not Applicable

Search NIH Clinical Center for Enthesopathy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: enthesopathy

Genetic Tests for Enthesopathy

Anatomical Context for Enthesopathy

MalaCards organs/tissues related to Enthesopathy:

42
Bone, Heart, Testes, Skin, Liver, Brain, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Enthesopathy:

20
The Entheses

Publications for Enthesopathy

Articles related to Enthesopathy:

(show top 50) (show all 1800)
# Title Authors Year
1
Is Palindromic Rheumatism a Pre-rheumatoid Arthritis Condition? Low Incidence of Rheumatoid Arthritis in Palindromic Rheumatism Patients Treated with Tight Control Strategy. ( 30987884 )
2019
2
Ultrasound-Guided Prolotherapy for Acromial Enthesopathy and Acromioclavicular Joint Arthropathy: A Single-Arm Prospective Study. ( 30171616 )
2019
3
Chikungunya Masquerading as Acute Rheumatism in an Omani Traveler. ( 30671186 )
2019
4
Tubulointerstitial Nephritis and Uveitis Syndrome with unilateral enthesopathy of the knee joint. ( 30419574 )
2019
5
SAPHO syndrome with enthesopathy. ( 30617190 )
2019
6
Distal interphalangeal joint extensor tendon enthesopathy in patients with nail psoriasis. ( 30842536 )
2019
7
Tophaceous Enthesopathy Mimicking Achilles Enthesitis. ( 31107699 )
2019
8
Identification of a distinct imaging phenotype may improve the management of palindromic rheumatism. ( 30297331 )
2019
9
Efficacy of rituximab in resistant palindromic rheumatism: first report in literature. ( 31076945 )
2019
10
Do the European League Against Rheumatism (EULAR) Sjögren's syndrome outcome measures correlate with impaired quality of life, fatigue, anxiety and depression in primary Sjögren's syndrome? ( 30002701 )
2018
11
Turkish League Against Rheumatism (TLAR) Recommendations for the Pharmacological Management of Rheumatoid Arthritis: 2018 Update Under Guidance of Current Recommendations. ( 30632540 )
2018
12
Management of Psoriatic Arthritis: Turkish League Against Rheumatism (TLAR) Expert Opinions. ( 30207576 )
2018
13
Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island. ( 29486812 )
2018
14
Post-chikungunya chronic inflammatory rheumatism: Follow-up of cases after 1 year of infection in Tolima, Colombia. ( 29203304 )
2018
15
Correction: 2016 American college of rheumatology/European league against rheumatism criteria for minimal moderate, and major clinical response in juvenile dermatomyositis. ( 29530915 )
2018
16
Presence of enthesopathy in patients with primary Sjogren's syndrome: ultrasonographic study of a local cohort. ( 28646319 )
2018
17
Clinical and ultrasonographic enthesopathy in inflammatory rheumatic diseases : Is MASEI or only calcaneal enthesitis sufficient? ( 29116386 )
2018
18
Enthesopathy in rheumatoid arthritis and spondyloarthritis: An ultrasound study. ( 29233691 )
2018
19
Aberrant TGF-β activation in bone tendon insertion induces enthesopathy-like disease. ( 29355842 )
2018
20
Subclinical enthesopathy of extensor digitorum tendon is highly prevalent and associated with clinical and ultrasound alterations of the adjacent fingernails in patients with psoriatic disease. ( 29706002 )
2018
21
Psoriasis and the risk of foot and ankle tendinopathy or enthesopathy in the absence of psoriatic arthritis: a population-based study. ( 29862046 )
2018
22
Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets. ( 30002128 )
2018
23
Comparative Efficacy and Safety of Nonsurgical Treatment Options for Enthesopathy of the Extensor Carpi Radialis Brevis: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials. ( 30380334 )
2018
24
Regression of Peripheral Subclinical Enthesopathy in Therapy-Naive Patients Treated With Ustekinumab for Moderate-to-Severe Chronic Plaque Psoriasis: A Fifty-Two-Week, Prospective, Open-Label Feasibility Study. ( 30468001 )
2018
25
Effect of Methotrexate in the Treatment of Distal Interphalangeal Joint Extensor Tendon Enthesopathy in Patients with Nail Psoriasis. ( 30558114 )
2018
26
Fibroblastic rheumatism: A case of multiple nodules of fingers and hands, contractures of fingers and polyarthritis. ( 29314178 )
2018
27
A case of Hajdu-Cheney syndrome associated with psoriatic rheumatism, two causes of acro-osteolysis. ( 28600213 )
2018
28
2017 update of the Turkish League Against Rheumatism (TLAR) evidence-based recommendations for the management of knee osteoarthritis. ( 29777340 )
2018
29
Progression of palindromic rheumatism to juvenile idiopathic arthritis in a Japanese girl carrying heterozygous L110P-E148Q substitutions of MEFV gene. ( 26457478 )
2018
30
Is palindromic rheumatism amongst children a benign disease? ( 29439723 )
2018
31
Risk of autoimmune rheumatic diseases in patients with palindromic rheumatism: A nationwide, population-based, cohort study. ( 30048527 )
2018
32
Ultrasound findings in palindromic rheumatism. ( 30552178 )
2018
33
Performance of the 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies in clinical practice. ( 29237619 )
2018
34
Response to: 'Performance of the 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies in clinical practice' by Hočevar et al. ( 29317406 )
2018
35
Application of the international league against rheumatism classification criteria for systemic juvenile idiopathic arthritis as a prognostic factor in patients with adults-onset Still's disease. ( 29370863 )
2018
36
The performance of the European League Against Rheumatism/American College of Rheumatology idiopathic inflammatory myopathies classification criteria in an expert-defined 10 year incident cohort. ( 30496561 )
2018
37
Correction: European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. ( 30097512 )
2018
38
Common language description of the term rheumatic and musculoskeletal diseases (RMDs) for use in communication with the lay public, healthcare providers and other stakeholders endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). ( 29525777 )
2018
39
Common Language Description of the Term Rheumatic and Musculoskeletal Diseases (RMDs) for Use in Communication With the Lay Public, Healthcare Providers, and Other Stakeholders Endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR). ( 29532625 )
2018
40
Homologies and heterogeneity between Rheumatology Congresses: Mexican, American College of Rheumatology and European League Against Rheumatism. ( 29891264 )
2018
41
Turkish League Against Rheumatism Consensus Report: Recommendations For Management of Axial Spondyloarthritis. ( 29900976 )
2018
42
Treatment of chronic inflammatory rheumatism by biotherapy in Gabon : eligibility and follow-up of the first 8 patients in sub-Saharan Africa. ( 29997080 )
2018
43
Response to: 'Ultrasound findings in palindromic rheumatism' by Sanmarti et al. ( 30578295 )
2018
44
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Adult Dermatomyositis and Polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28382787 )
2017
45
2016 American College of Rheumatology/European League Against Rheumatism criteria for minimal, moderate, and major clinical response in adult dermatomyositis and polymyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28385805 )
2017
46
Impaired quality of life after chikungunya virus infection: a 12-month follow-up study of its chronic inflammatory rheumatism in La Virginia, Risaralda, Colombia. ( 28828632 )
2017
47
Would be IL-6 a missing link between chronic inflammatory rheumatism and depression after chikungunya infection? ( 28550401 )
2017
48
Letter to the Editor: Chikungunya Virus Infection-An Update on Chronic Rheumatism in Latin America. ( 28178441 )
2017
49
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28382778 )
2017
50
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative. ( 28385804 )
2017

Variations for Enthesopathy

Expression for Enthesopathy

Search GEO for disease gene expression data for Enthesopathy.

Pathways for Enthesopathy

GO Terms for Enthesopathy

Biological processes related to Enthesopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 biomineral tissue development GO:0031214 9.26 DMP1 PHEX
2 cellular response to vitamin D GO:0071305 9.16 FGF23 PHEX
3 cellular response to parathyroid hormone stimulus GO:0071374 8.96 FGF23 PHEX
4 response to sodium phosphate GO:1904383 8.62 FGF23 PHEX

Sources for Enthesopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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