MCID: ENT005
MIFTS: 34

Entropion

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Entropion

MalaCards integrated aliases for Entropion:

Name: Entropion 12 6 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12397
ICD9CM 34 374.00
MeSH 43 D004774
SNOMED-CT 67 33168009
UMLS 71 C0014390

Summaries for Entropion

MalaCards based summary : Entropion is related to senile entropion and cicatricial entropion, and has symptoms including erythema of the eyelids An important gene associated with Entropion is POLR3A (RNA Polymerase III Subunit A). The drugs Sevoflurane and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and salivary gland.

Wikipedia : 74 Entropion is a medical condition in which the eyelid (usually the lower lid) folds inward. It is very... more...

Related Diseases for Entropion

Diseases in the Entropion family:

Rare Disorder with Entropion

Diseases related to Entropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 senile entropion 34.0 LAX1 DCXR
2 cicatricial entropion 32.9 NAGPA LTB4R LAX1 DNAJC15 DCXR
3 senile ectropion 30.8 SRCIN1 LAX1 DCXR
4 lagophthalmos 30.6 LTB4R LAX1 DCXR
5 cicatricial ectropion 30.2 SRCIN1 LAX1 DCXR
6 eyelid disease 30.1 SRCIN1 LTB4R LAX1 DCXR
7 excessive tearing 30.0 SRCIN1 LAX1 DCXR
8 spastic entropion 12.4
9 mechanical entropion 12.3
10 isolated congenital entropion 12.3
11 rare disorder with entropion 12.1
12 rare genetic disorder with entropion 12.1
13 obsolete: congenital entropion 12.1
14 obsolete: secondary entropion 12.1
15 kaufman oculocerebrofacial syndrome 11.3
16 wiedemann-rautenstrauch syndrome 11.3
17 pyramidal molars-abnormal upper lip syndrome 11.3
18 ectropion 10.8
19 trachoma 10.6
20 ptosis 10.5
21 bullous pemphigoid 10.5
22 epiblepharon 10.5
23 blepharospasm 10.5
24 ocular cicatricial pemphigoid 10.4
25 erythema multiforme 10.4
26 cicatricial pemphigoid 10.4
27 severe cutaneous adverse reaction 10.4
28 enophthalmos 10.4
29 erythema multiforme major 10.4
30 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.4
31 distichiasis 10.4
32 keratopathy 10.4
33 keratitis, hereditary 10.3
34 conjunctivitis 10.3
35 yemenite deaf-blind hypopigmentation syndrome 10.2
36 chronic dacryocystitis 10.2 SRCIN1 DCXR
37 dacryocystitis 10.2 SRCIN1 DCXR
38 corneal ulcer 10.2
39 hard palate cancer 10.2
40 blepharitis 10.2
41 acute inflammation of lacrimal passage 10.1 SRCIN1 DCXR
42 astigmatism 10.1
43 intraocular pressure quantitative trait locus 10.1
44 muscle hypertrophy 10.1
45 basal cell carcinoma 10.1
46 cutis laxa 10.1
47 cataract 10.1
48 secondary ectropion 10.1
49 internal hordeolum 10.1 SRCIN1 DCXR
50 chronic inflammation of lacrimal passage 10.1 SRCIN1 LAX1 DCXR

Comorbidity relations with Entropion via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Entropion:



Diseases related to Entropion

Symptoms & Phenotypes for Entropion

UMLS symptoms related to Entropion:


erythema of the eyelids

Drugs & Therapeutics for Entropion

Drugs for Entropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved 28523-86-6 5206
2
Ketamine Approved, Vet_approved 6740-88-1 3821
3
Desflurane Approved 57041-67-5 42113
4
Fluorometholone Approved, Investigational 426-13-1 9878
5 Analgesics
6 Neurotransmitter Agents
7 Anesthetics
8 Platelet Aggregation Inhibitors
9 Anesthetics, General
10 Central Nervous System Depressants
11 Anesthetics, Dissociative
12 Anesthetics, Intravenous
13 Anesthetics, Inhalation
14 Excitatory Amino Acid Antagonists
15 Excitatory Amino Acids
16 Lubricant Eye Drops
17 Pharmaceutical Solutions
18 Hormone Antagonists
19 Ophthalmic Solutions
20 Anti-Inflammatory Agents
21 glucocorticoids
22 Hormones
23 Anti-Allergic Agents
24 Lycium
25 Goji
26 Chrysanthemum
27 Antitubercular Agents
28 Anti-Bacterial Agents
29 Antibiotics, Antitubercular
30 Anti-Infective Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Non-absorbable (Silk) Sutures Verses Absorbable (Vicryl) Sutures During the Surgical Treatment of Trachomatous Trichiasis Completed NCT00522860 Phase 4
2 Post-Marketing Clinical Follow-up (PMCF) Study in Ophthalmic Surgery to Evaluate the Safety and Efficacy of Novosyn® Quick Suture Material. A Multicenter Randomized, Active-controlled, Double-blinded, Prospective, Observational Study. Withdrawn NCT02761083 Phase 4
3 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610
4 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
5 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
6 The Effect of Preoperative Ketamine on the Emergence Characteristics After Desflurane or Sevoflurane Anesthesia in Children Undergoing Entropion Surgery Completed NCT02916407 Sevoflurane;Desflurane
7 Minimally Invasive Holmium:YAG Laser Blepharoplasty Completed NCT00842764
8 A Prospective Double-blind Interventional Study of Tissue Reaction to Polyglycolic Acid Sutures in Human Skin Completed NCT01598376
9 A Randomised Controlled Trial of Epilation Verses Immediate Surgery for the Management of Minor Trachomatous Trichiasis Completed NCT00522912
10 Fluorometholone 0.1% as Perioperative Adjunct Therapy for Lid-rotation Surgery in Trachomatous Entropion and Trichiasis, Dose-varying Study Completed NCT01949454 Fluorometholone 0.1% ophthalmic solution
11 Salivary Gland and Labial Mucous Membrane Transplantation in the Treatment of Severe Symblepharon and Dry Eye in Patients With Stevens-Johnson Syndrome. Completed NCT01178242
12 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
13 Lacrimal Drainage Resistance Study Completed NCT01766232
14 Randomised Research Comparing Acupuncture, Herbal Treatment and Artificial Tear Eye Drops in Dry Eye Completed NCT02219204
15 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374

Search NIH Clinical Center for Entropion

Cochrane evidence based reviews: entropion

Genetic Tests for Entropion

Anatomical Context for Entropion

MalaCards organs/tissues related to Entropion:

40
Eye, Skin, Salivary Gland, Thyroid, Testes, Brain, Bone Marrow

Publications for Entropion

Articles related to Entropion:

(show top 50) (show all 1110)
# Title Authors PMID Year
1
Surgical management of bilateral, upper and lower eyelid entropion in 27 Shar Pei dogs, using the Stades forced granulation procedure of the upper eyelid only. 61
31738860 2020
2
A conjunctival-sparing surgical technique for lower eyelid cicatricial entropion repair in ocular cicatricial pemphigoid. 61
30732510 2020
3
A genome-wide significant association on chromosome 15 for congenital entropion in Swiss White Alpine sheep. 61
31945208 2020
4
Recognising meibomian gland inversion in patients with facial palsy to improve the ocular surface. 61
31893955 2020
5
Assessment of the Safety and Efficacy of Prolapsed Orbital Fat Resection During Involutional Entropion Repair. 61
31567912 2020
6
Shallow periorbital injection of triamcinolone acetonide in treatment of lower eyelid entropion related to thyroid-associated ophthalmopathy: Three case reports. 61
32000449 2020
7
Septo-capsulopalpebral fascial recession flap technique in lower blepharoplasty: An experience of 453 consecutive cases and a review of the literature. 61
31519503 2020
8
The Role of Overriding Preseptal Orbicularis Oculi Muscle in Development of Involutional Lower Eyelid Entropion: Microscopic Viewpoints. 61
31842078 2019
9
Oculoplastic aspects of ocular surface disease and their management. 61
31837384 2019
10
[Surgical management of firework-induced eyelid injuries]. 61
31713068 2019
11
Meibomian gland inversion: under-recognized entity. 61
31184427 2019
12
A New Surgical Technique Used for Correction of Congenital Blepharoptosis. 61
31844945 2019
13
Distichiasis in association with entropion in metastatic HER2-positive breast cancer treated by pertuzumab, trastuzumab, and docetaxel combination chemotherapy. 61
31749208 2019
14
The Use of Umbilical Amnion for Conjunctival Socket, Fornix, and Eyelid Margin Reconstruction. 61
31770177 2019
15
A Comparison of Surgical Outcomes of Two Combination Surgeries for Involutional Entropion: Fixing 3 vs 2 Pathologic Components. 61
31478956 2019
16
Blood Perfusion in Rotational Full-Thickness Lower Eyelid Flaps Measured by Laser Speckle Contrast Imaging. 61
31876674 2019
17
Analysis of Risk Factors Associated With Drooping Deformity After Lower Eyelid Reconstruction: A Newly Developed Drooping Index. 61
31800560 2019
18
Surgical Feasibility of Curtler-Beard Reconstruction for Large Upper Eyelid Defect. 61
31283641 2019
19
Swinging Eyelid Approach to Zygomaticomaxillary Complex Fracture. 61
31574788 2019
20
Four Practical Reconstructive Techniques Using the Transantral Approach to the Orbital Floor Without the Need for an Endoscope. 61
31260675 2019
21
A small incision technique for repairing involutional lower eyelid entropion. 61
31606822 2019
22
The impact of surgical training on the practice of recently graduated ophthalmologists at Riyadh's ophthalmology residency program. 61
31920440 2019
23
Pigmentary keratitis in pugs in the United Kingdom: prevalence and associated features. 61
31666065 2019
24
Simultaneous Forehead Lift and Blepharoplasty Techniques in Management of Orbito-Temporal Plexiform Neurofibroma. 61
30889063 2019
25
Prosthesis-socket volume imbalance and dermofat graft rehabilitation in patients with an anophthalmic socket. 61
31531549 2019
26
Randomized Controlled Trial Comparing Everting Sutures with a Lateral Tarsal Strip for Involutional Lower Eyelid Entropion. 61
31127533 2019
27
Risk of Lower Eyelids Malposition in Subciliary Compared to Transconjunctival Approach in Maxillofacial Fractures Management: A Systematic Review and Meta-Analysis. 61
31844463 2019
28
Pros and Cons of the Transconjunctival Retroseptal Approach to the Isolated Orbital Floor Fracture. 61
30896523 2019
29
A comparison of the lateral tarsal strip with everting sutures and the Quickert procedure for involutional entropion. 61
30916886 2019
30
Involutional lower eyelid entropion: causative factors and therapeutic management. 61
30315389 2019
31
Mini-incisional entropion repair for correcting involutional entropion: Full description and surgical outcome. 61
31415368 2019
32
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. 61
30054850 2019
33
Potential Effect of Epilation on the Outcome of Surgery for Trachomatous Trichiasis. 61
31489257 2019
34
Comparison of the efficacy of different cell sources for transplantation in total limbal stem cell deficiency. 61
31004182 2019
35
Comparison of four Combined Procedures for Correction of Involutional Lower Eyelid Entropion. 61
30882581 2019
36
Re: "Association of Involutional Lower Eyelid Entropion With Reduced Upper Eyelid Position Relative to the Corneal Light Reflex: Quantification of Facial Asymmetry". 61
31793921 2019
37
Reply Re: "Association of Involutional Lower Eyelid Entropion With Reduced Upper Eyelid Position Relative to the Corneal Light Reflex: Quantification of Facial Asymmetry". 61
31793922 2019
38
Lower eyelid tension balance reconstruction: A new procedure for the repair of congenital epiblepharon with epicanthus. 61
30616908 2019
39
Eyelid Malposition Repair: A Review of the Literature and Current Techniques. 61
31037045 2019
40
A Novel Plastic Surgical Technique for Treating Congenital Entropion in Asians. 61
31321164 2019
41
Involutional entropion repair combining the modified Bick quick strip procedure with Quickert rotational sutures. 61
30024812 2019
42
The use of hyaluronic acid subdermal filler for entropion in canines and felines: 40 cases. 61
29520917 2019
43
Exposure, entropion, and bilateral corneal ulceration in a newborn as a manifestation of chromosome 22 q11.2 duplication syndrome. 61
30505980 2019
44
Surgical correction of involutional lower lid entropion with lateral canthal eyelid block excision and imbrication of the capsulopalpebral ligament using non-buried non-resorbable imbricating sutures versus buried resorbable imbricating sutures. 61
29498554 2019
45
Wedge resection of the tarsal plate combined with the modified Hotz procedure for correction of involutional lower eyelid entropion. 61
30851760 2019
46
Aesthetic Outcome of a Case of Orbital Floor Fracture Treated Using a Retroseptal Transconjunctival Approach. 61
31016090 2019
47
Reconstruction of Upper Eyelid Defects Secondary to Malignant Tumors with a Newly Modified Cutler-Beard Technique with Tarsoconjunctival Graft. 61
30944732 2019
48
Correction of Recalcitrant Cicatricial Lower Lid Retraction and Entropion With Transverse Tarsotomy and Tarsoconjunctival Flap. 61
30365475 2019
49
Evaluation of transconjunctival thermal electrocautery for treatment of canine distichiasis: 88 eyelids (2013-2016). 61
29493866 2019
50
Various Manifestations Of Trachoma In Internally Displaced Rural Population - A Free Eye Camp Based Survey. 61
30868779 2019

Variations for Entropion

ClinVar genetic disease variations for Entropion:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XY;inv(6)(p22q13)dninversion Pathogenic 267941

Expression for Entropion

Search GEO for disease gene expression data for Entropion.

Pathways for Entropion

GO Terms for Entropion

Sources for Entropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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