Aliases & Classifications for Entropion

MalaCards integrated aliases for Entropion:

Name: Entropion 12 29 6 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12397
ICD9CM 35 374.00
MeSH 44 D004774
UMLS 73 C0014390

Summaries for Entropion

MalaCards based summary : Entropion is related to senile entropion and lagophthalmos, and has symptoms including erythema of the eyelids An important gene associated with Entropion is MYO3B (Myosin IIIB). The drugs Desflurane and Isoflurane have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 76 Entropion is a medical condition in which the eyelid (usually the lower lid) folds inward. It is very... more...

Related Diseases for Entropion

Diseases related to Entropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 senile entropion 32.9 FOXD3 MBD5
2 lagophthalmos 28.0 DOCK8 DRD5 MBD5
3 cicatricial entropion 12.1
4 spastic entropion 12.1
5 mechanical entropion 12.1
6 ackerman syndrome 11.0
7 ectropion 10.5
8 spasticity 10.4
9 trachoma 10.2
10 epiblepharon 10.2
11 aging 10.0
12 ocular cicatricial pemphigoid 10.0
13 cicatricial pemphigoid 10.0
14 ptosis 9.9
15 mucositis 9.9
16 cutis laxa 9.9
17 paralytic lagophthalmos 9.9 DOCK8 MBD5
18 distichiasis 9.8
19 severe cutaneous adverse reaction 9.8
20 cataract 9.8
21 senile ectropion 9.8
22 blepharospasm 9.8
23 corneal ulcer 9.8
24 hemifacial spasm 9.8
25 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.8
26 epicanthus 9.7
27 hemifacial hyperplasia 9.7
28 trichorhinophalangeal syndrome, type ii 9.7
29 glaucoma 3, primary congenital, a 9.7
30 hallermann-streiff syndrome 9.7
31 blepharospasm, benign essential 9.7
32 muscle hypertrophy 9.7
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
34 hematopoietic stem cell transplantation 9.7
35 erythema multiforme 9.7
36 sensorineural hearing loss 9.7
37 corneal disease 9.7
38 enophthalmos 9.7
39 allergic conjunctivitis 9.7
40 primary angle-closure glaucoma 9.7
41 blepharoconjunctivitis 9.7
42 dermatitis 9.7
43 retinitis 9.7
44 dystonia 9.7
45 conjunctivitis 9.7
46 fundus dystrophy 9.7
47 lichen planus 9.7
48 esotropia 9.7
49 hypotropia 9.7
50 type i 9.7

Comorbidity relations with Entropion via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Entropion:



Diseases related to Entropion

Symptoms & Phenotypes for Entropion

UMLS symptoms related to Entropion:


erythema of the eyelids

GenomeRNAi Phenotypes related to Entropion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.32 DRD5 MYO3B
2 Decreased substrate adherent cell growth GR00193-A-3 9.32 DRD5 MYO3B
3 Decreased substrate adherent cell growth GR00193-A-4 9.32 MYO3B

MGI Mouse Phenotypes related to Entropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.1 DOCK8 DRD5 FOXD3 MBD5 MYO3B SRCIN1

Drugs & Therapeutics for Entropion

Drugs for Entropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desflurane Approved Not Applicable 57041-67-5 42113
2
Isoflurane Approved, Vet_approved Not Applicable 26675-46-7 3763
3
Ketamine Approved, Vet_approved Not Applicable 6740-88-1 3821
4
Sevoflurane Approved, Vet_approved Not Applicable 28523-86-6 5206
5
Fluorometholone Approved, Investigational Not Applicable 426-13-1 9878
6 Pharmaceutical Solutions Not Applicable
7 Analgesics Not Applicable
8 Anesthetics Not Applicable
9 Anesthetics, Dissociative Not Applicable
10 Anesthetics, General Not Applicable
11 Anesthetics, Inhalation Not Applicable
12 Anesthetics, Intravenous Not Applicable
13 Central Nervous System Depressants Not Applicable
14 Excitatory Amino Acid Antagonists Not Applicable
15 Excitatory Amino Acids Not Applicable
16 Neurotransmitter Agents Not Applicable
17 Peripheral Nervous System Agents Not Applicable
18 Platelet Aggregation Inhibitors Not Applicable
19 Anti-Allergic Agents Not Applicable
20 Anti-Inflammatory Agents Not Applicable
21 glucocorticoids Not Applicable
22 Hormone Antagonists Not Applicable
23 Hormones Not Applicable
24 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
25 Lubricant Eye Drops Not Applicable
26 Ophthalmic Solutions Not Applicable
27 Tetrahydrozoline Not Applicable
28 Anti-Bacterial Agents Not Applicable
29 Antibiotics, Antitubercular Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Trial of Non-absorbable Versus Absorbable Sutures for Trichiasis Surgery Completed NCT00522860 Phase 4
2 PMCF-study Using Novosyn® Quick Suture Material in Ophthalmic Surgery Withdrawn NCT02761083 Phase 4
3 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610 Not Applicable
4 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 Not Applicable saline solution
5 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718 Not Applicable
6 The Effect of Preoperative Ketamine on the Emergence Characteristics in Children Undergoing Entropion Surgery Completed NCT02916407 Not Applicable Sevoflurane;Desflurane
7 A Prospective Double-blind Interventional Study of Tissue Reaction to Polyglycolic Acid Sutures in Human Skin Completed NCT01598376 Not Applicable
8 Minimally Invasive Holmium:YAG Laser Blepharoplasty Completed NCT00842764 Not Applicable
9 Fluorometholone as Ancillary Therapy for TT Surgery Completed NCT01949454 Not Applicable Fluorometholone 0.1% ophthalmic solution
10 A Trial of Epilation Verses Surgery for Minor Trichiasis Completed NCT00522912 Not Applicable
11 Lacrimal Drainage Resistance Study Completed NCT01766232
12 Validating the Diagnostic Accuracy of Mediview 2.0 Software as an Image Analysis Tool of Meibomian Glands Completed NCT01991132 Not Applicable
13 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Not Applicable Salt solution
14 IRIS Registry: Intelligent Research in Sight Registry Recruiting NCT02485847

Search NIH Clinical Center for Entropion

Cochrane evidence based reviews: entropion

Genetic Tests for Entropion

Genetic tests related to Entropion:

# Genetic test Affiliating Genes
1 Entropion 29

Anatomical Context for Entropion

MalaCards organs/tissues related to Entropion:

41
Skin, Eye, Testes

Publications for Entropion

Articles related to Entropion:

(show top 50) (show all 499)
# Title Authors Year
1
Anterior tarsal flap rotation combined with anterior lamellar reposition in the repair of cicatricial upper eyelid entropion. ( 29538594 )
2018
2
Correction of upper eyelid entropion: Modified techniques are most welcome. ( 29380775 )
2018
3
Association of Involutional Lower Eyelid Entropion with Reduced Upper Eyelid Position Relative to the Corneal Light Reflex: Quantification of Facial Asymmetry. ( 29342029 )
2018
4
Surgical correction of involutional lower lid entropion with lateral canthal eyelid block excision and imbrication of the capsulopalpebral ligament using non-buried non-resorbable imbricating sutures versus buried resorbable imbricating sutures. ( 29498554 )
2018
5
The use of hyaluronic acid subdermal filler for entropion in canines and felines: 40 cases. ( 29520917 )
2018
6
Management of Severe Cicatricial Entropion With Labial Mucous Membrane Graft in Cicatricial Ocular Surface Disorders. ( 29762330 )
2018
7
Comment on "Anterior lamellar recession for management of upper eyelid cicatricial entropion and associated eyelid abnormalities". ( 29977827 )
2018
8
Entropion and ectropion repair: a snapshot of surgical practice in the United Kingdom. ( 29053043 )
2017
9
Diagnosis, Treatment, and Surgical Repair in a Case of Isolated Conjunctival Lichen Planus Causing Cicatricial Entropion. ( 28538610 )
2017
10
Lower eyelid entropion repair with retractor mobilization and insertion onto the anterior surface of the tarsal plate. ( 29040033 )
2017
11
Lateral tarsoligamentous sling: A successful treatment for involutional entropion in Asians as a modified lateral tarsal strip. ( 28847622 )
2017
12
Congenital entropion and hypotropia secondary to duplication of the inferior rectus muscle. ( 28089746 )
2017
13
Success rate of nurse-led everting sutures for involutional lower lid entropion. ( 28085138 )
2017
14
"The influence of orbital vector on involutional entropion and ectropion". ( 28853964 )
2017
15
Lateral tarsal strip plus skin-muscle flap excision in the treatment of lower eyelid involutional entropion. ( 28837414 )
2017
16
Entropion ( 29262221 )
2017
17
Eyelid Reconstruction, Entropion ( 29262117 )
2017
18
Anterior lamellar recession for management of upper eyelid cicatricial entropion and associated eyelid abnormalities. ( 29259900 )
2017
19
Orbicularis oculi muscle tightening for involutional entropion. ( 28268157 )
2017
20
Correction of involutional entropion with retractor redirection. ( 27322152 )
2016
21
Involvement of inward upper eyelid push on the lower eyelid during eyelid closure in development of involutional lower eyelid entropion. ( 27013384 )
2016
22
Modified lateral tarsal strip for involutional entropion and ectropion surgery. ( 27817116 )
2016
23
Manual Provocation Test for Intermittent Involutional Entropion. ( 26890660 )
2016
24
Posterior layer advancement of lower eyelid retractors with transcanthal canthopexy for involutional lower eyelid entropion. ( 27419836 )
2016
25
Shared buccal mucosal graft for simultaneous repair of severe upper and lower eyelid cicatricial entropion. ( 26710260 )
2016
26
Histopathological changes in involutional lower eyelid entropion: the tarsus is thickened! ( 27938962 )
2016
27
Comparison of Surgical Outcome Between Quickert Suture and Quickert Suture With Modified Lateral Tarsal Strip in Involutional Lower Eyelid Entropion. ( 26703055 )
2016
28
The prevalence of glaucoma in patients undergoing surgery for eyelid entropion or ectropion. ( 27785003 )
2016
29
Anterior lamellar recession, blepharoplasty, and supratarsal fixation for cicatricial upper eyelid entropion without lagophthalmos. ( 26869158 )
2016
30
Modified tarsotomy for the treatment of severe cicatricial entropion. ( 27101749 )
2016
31
Senile lower lid entropion successfully treated with botulinum toxin A. ( 26777720 )
2016
32
Long-Term Results for Entropion Repair by Tarsal Margin Rotation With Posterior Lamella Superadvancement. ( 27861402 )
2016
33
Are You Missing an Entropion? The Test of Induced Entropion 2. ( 26425881 )
2015
34
Management of Patients With Confirmed andA Presumed Mucous Membrane Pemphigoid Undergoing Entropion Repair. ( 25644537 )
2015
35
Marginal Entropion: A Frequently Overlooked Eyelid Malposition. ( 27800233 )
2015
36
Genome-Wide Association Identifies SLC2A9 and NLN Gene Regions as Associated with Entropion in Domestic Sheep. ( 26098909 )
2015
37
Upper lid crease approach for margin rotation in trachomatous cicatricial entropion without external sutures. ( 26677040 )
2015
38
A Case of a Bilateral Cicatricial Upper Eyelid Entropion After Hematopoietic Stem Cell Transplantation in Mucopolysaccharidosis Type I. ( 26588207 )
2015
39
A hammock flap: A modified backflip flap for the surgical correction of cicatricial entropion. ( 25694396 )
2015
40
Involutional entropion: risk factors and surgical remedies. ( 26154839 )
2015
41
Correction of lower eyelid marginal entropion by eyelid margin splitting and anterior lamellar repositioning. ( 24398488 )
2014
42
Orbicularis oculi muscle transposition for repairing involutional lower eyelid entropion. ( 24947549 )
2014
43
What is the best strategy for Asians with involutional entropion? ( 24777025 )
2014
44
Surgical correction of congenital entropion in related Boer goat kids using a combination Hotz-Celsus and lateral eyelid wedge resection procedure. ( 25338664 )
2014
45
Syringoid eccrine carcinoma of the eyelid presenting as cicatricial entropion. ( 25349816 )
2014
46
Anatomical characteristics and surgical treatment of bilateral congenital upper eyelid entropion in an infant with neonatal progeroid syndrome. ( 24807800 )
2014
47
Another case of neonatal progeroid syndrome and bilateral congenital upper eyelid entropion. ( 25069079 )
2014
48
Age-matched, case-controlled comparison of clinical indicators for development of entropion and ectropion. ( 24734167 )
2014
49
Lower eyelid involutional entropion repair with lateral tarsal strip and infraciliary rotation sutures: surgical technique and outcomes. ( 24660998 )
2014
50
Bilateral congenital entropion with cutis laxa. ( 24517732 )
2014

Variations for Entropion

ClinVar genetic disease variations for Entropion:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XY;inv(6)(p22q13)dn inversion Pathogenic

Expression for Entropion

Search GEO for disease gene expression data for Entropion.

Pathways for Entropion

GO Terms for Entropion

Sources for Entropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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