MCID: ENT005
MIFTS: 35

Entropion

Categories: Eye diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Entropion

MalaCards integrated aliases for Entropion:

Name: Entropion 12 6 44 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:12397
ICD9CM 35 374.00
MeSH 44 D004774
SNOMED-CT 68 33168009
UMLS 72 C0014390

Summaries for Entropion

MalaCards based summary : Entropion is related to senile entropion and cicatricial entropion, and has symptoms including erythema of the eyelids An important gene associated with Entropion is MYO3B (Myosin IIIB). The drugs Desflurane and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and salivary gland.

Wikipedia : 75 Entropion is a medical condition in which the eyelid (usually the lower lid) folds inward. It is very... more...

Related Diseases for Entropion

Diseases in the Entropion family:

Rare Disorder with Entropion

Diseases related to Entropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 senile entropion 12.5
2 cicatricial entropion 12.4
3 spastic entropion 12.4
4 mechanical entropion 12.3
5 isolated congenital entropion 12.3
6 rare disorder with entropion 12.1
7 rare genetic disorder with entropion 12.1
8 obsolete: congenital entropion 12.1
9 obsolete: secondary entropion 12.1
10 kaufman oculocerebrofacial syndrome 11.3
11 wiedemann-rautenstrauch syndrome 11.3
12 pyramidal molars-abnormal upper lip syndrome 11.3
13 ectropion 10.8
14 trachoma 10.6
15 ptosis 10.5
16 bullous pemphigoid 10.5
17 epiblepharon 10.5
18 senile ectropion 10.5
19 blepharospasm 10.4
20 ocular cicatricial pemphigoid 10.4
21 erythema multiforme 10.4
22 cicatricial pemphigoid 10.4
23 severe cutaneous adverse reaction 10.4
24 erythema multiforme major 10.4
25 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.4
26 enophthalmos 10.4
27 keratopathy 10.4
28 distichiasis 10.3
29 conjunctivitis 10.3
30 keratitis, hereditary 10.3
31 lagophthalmos 10.3
32 yemenite deaf-blind hypopigmentation syndrome 10.2
33 hard palate cancer 10.2
34 blepharitis 10.2
35 astigmatism 10.1
36 intraocular pressure quantitative trait locus 10.1
37 muscle hypertrophy 10.1
38 basal cell carcinoma 10.1
39 cutis laxa 10.1
40 cataract 10.1
41 corneal ulcer 10.1
42 secondary ectropion 10.1
43 epicanthus 10.0
44 glaucoma, primary open angle 10.0
45 hemifacial spasm, familial 10.0
46 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
47 apraxia of eyelid opening 10.0
48 graft-versus-host disease 10.0
49 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.0
50 apraxia 10.0

Comorbidity relations with Entropion via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Entropion:



Diseases related to Entropion

Symptoms & Phenotypes for Entropion

UMLS symptoms related to Entropion:


erythema of the eyelids

Drugs & Therapeutics for Entropion

Drugs for Entropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desflurane Approved 57041-67-5 42113
2
Sevoflurane Approved, Vet_approved 28523-86-6 5206
3
Ketamine Approved, Vet_approved 6740-88-1 3821
4
Fluorometholone Approved, Investigational 426-13-1 9878
5 Neurotransmitter Agents
6 Analgesics
7 Peripheral Nervous System Agents
8 Anesthetics
9 Central Nervous System Depressants
10 Platelet Aggregation Inhibitors
11 Excitatory Amino Acid Antagonists
12 Anesthetics, General
13 Anesthetics, Inhalation
14 Anesthetics, Dissociative
15 Anesthetics, Intravenous
16 Excitatory Amino Acids
17 Ophthalmic Solutions
18 Anti-Allergic Agents
19 glucocorticoids
20 Anti-Inflammatory Agents
21 Hormones
22 Lubricant Eye Drops
23 Pharmaceutical Solutions
24 Hormone Antagonists
25 Hormones, Hormone Substitutes, and Hormone Antagonists
26 Chrysanthemum
27 Lycium
28 Goji
29 Anti-Infective Agents
30 Antitubercular Agents
31 Antibiotics, Antitubercular
32 Anti-Bacterial Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Non-absorbable (Silk) Sutures Verses Absorbable (Vicryl) Sutures During the Surgical Treatment of Trachomatous Trichiasis Completed NCT00522860 Phase 4
2 Post-Marketing Clinical Follow-up (PMCF) Study in Ophthalmic Surgery to Evaluate the Safety and Efficacy of Novosyn® Quick Suture Material. A Multicenter Randomized, Active-controlled, Double-blinded, Prospective, Observational Study. Withdrawn NCT02761083 Phase 4
3 Assessment of Changes of Periocular Skin Sensation Following Eyelid and Ocular Surface Surgeries Unknown status NCT02638610
4 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
5 Eyelash Line Resection for Entropion Associated With Down's Syndrome Completed NCT01758718
6 The Effect of Preoperative Ketamine on the Emergence Characteristics After Desflurane or Sevoflurane Anesthesia in Children Undergoing Entropion Surgery Completed NCT02916407 Sevoflurane;Desflurane
7 Minimally Invasive Holmium:YAG Laser Blepharoplasty Completed NCT00842764
8 A Prospective Double-blind Interventional Study of Tissue Reaction to Polyglycolic Acid Sutures in Human Skin Completed NCT01598376
9 A Randomised Controlled Trial of Epilation Verses Immediate Surgery for the Management of Minor Trachomatous Trichiasis Completed NCT00522912
10 Fluorometholone 0.1% as Perioperative Adjunct Therapy for Lid-rotation Surgery in Trachomatous Entropion and Trichiasis, Dose-varying Study Completed NCT01949454 Fluorometholone 0.1% ophthalmic solution
11 Salivary Gland and Labial Mucous Membrane Transplantation in the Treatment of Severe Symblepharon and Dry Eye in Patients With Stevens-Johnson Syndrome. Completed NCT01178242
12 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
13 Lacrimal Drainage Resistance Study Completed NCT01766232
14 Randomised Research Comparing Acupuncture, Herbal Treatment and Artificial Tear Eye Drops in Dry Eye Completed NCT02219204
15 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374

Search NIH Clinical Center for Entropion

Cochrane evidence based reviews: entropion

Genetic Tests for Entropion

Anatomical Context for Entropion

MalaCards organs/tissues related to Entropion:

41
Eye, Skin, Salivary Gland, Testes, Brain, Thyroid, Bone Marrow

Publications for Entropion

Articles related to Entropion:

(show top 50) (show all 1086)
# Title Authors PMID Year
1
Randomized Controlled Trial Comparing Everting Sutures with a Lateral Tarsal Strip for Involutional Lower Eyelid Entropion. 38
31127533 2019
2
A comparison of the lateral tarsal strip with everting sutures and the Quickert procedure for involutional entropion. 38
30916886 2019
3
Involutional lower eyelid entropion: causative factors and therapeutic management. 38
30315389 2019
4
Vector analysis of changes in corneal astigmatism following lateral tarsal strip procedure in patients with involutional ectropion or entropion. 38
30054850 2019
5
Mini-incisional entropion repair for correcting involutional entropion: Full description and surgical outcome. 38
31415368 2019
6
Surgical Feasibility of Curtler-Beard Reconstruction for Large Upper Eyelid Defect. 38
31283641 2019
7
Comparison of the efficacy of different cell sources for transplantation in total limbal stem cell deficiency. 38
31004182 2019
8
Four Practical Reconstructive Techniques Using the Transantral Approach to the Orbital Floor Without the Need for an Endoscope. 38
31260675 2019
9
Comparison of four Combined Procedures for Correction of Involutional Lower Eyelid Entropion. 38
30882581 2019
10
Meibomian gland inversion: under-recognized entity. 38
31184427 2019
11
Eyelid Malposition Repair: A Review of the Literature and Current Techniques. 38
31037045 2019
12
Lower eyelid tension balance reconstruction: A new procedure for the repair of congenital epiblepharon with epicanthus. 38
30616908 2019
13
A Novel Plastic Surgical Technique for Treating Congenital Entropion in Asians. 38
31321164 2019
14
Involutional entropion repair combining the modified Bick quick strip procedure with Quickert rotational sutures. 38
30024812 2019
15
The use of hyaluronic acid subdermal filler for entropion in canines and felines: 40 cases. 38
29520917 2019
16
Pros and Cons of The Transconjunctival Retroseptal Approach to The Isolated Orbital Floor Fracture. 38
30896523 2019
17
Simultaneous Forehead Lift and Blepharoplasty Techniques in Management of Orbito-Temporal Plexiform Neurofibroma. 38
30889063 2019
18
Exposure, entropion, and bilateral corneal ulceration in a newborn as a manifestation of chromosome 22 q11.2 duplication syndrome. 38
30505980 2019
19
A conjunctival-sparing surgical technique for lower eyelid cicatricial entropion repair in ocular cicatricial pemphigoid. 38
30732510 2019
20
Aesthetic Outcome of a Case of Orbital Floor Fracture Treated Using a Retroseptal Transconjunctival Approach. 38
31016090 2019
21
Wedge resection of the tarsal plate combined with the modified Hotz procedure for correction of involutional lower eyelid entropion. 38
30851760 2019
22
Surgical correction of involutional lower lid entropion with lateral canthal eyelid block excision and imbrication of the capsulopalpebral ligament using non-buried non-resorbable imbricating sutures versus buried resorbable imbricating sutures. 38
29498554 2019
23
Reconstruction of Upper Eyelid Defects Secondary to Malignant Tumors with a Newly Modified Cutler-Beard Technique with Tarsoconjunctival Graft. 38
30944732 2019
24
Correction of Recalcitrant Cicatricial Lower Lid Retraction and Entropion With Transverse Tarsotomy and Tarsoconjunctival Flap. 38
30365475 2019
25
Evaluation of transconjunctival thermal electrocautery for treatment of canine distichiasis: 88 eyelids (2013-2016). 38
29493866 2019
26
Various Manifestations Of Trachoma In Internally Displaced Rural Population - A Free Eye Camp Based Survey. 38
30868779 2019
27
A search for trachoma in Timor-Leste: no evidence to justify undertaking population-based prevalence surveys. 38
30806540 2018
28
Combined pentagonal resection and inferior retractor plication in involutional entropion. 38
30567578 2018
29
What surgical approach has the lowest risk of the lower lid complications in the treatment of orbital floor and periorbital fractures? A frequentist network meta-analysis. 38
30337055 2018
30
Frontalis-Orbicularis Muscle Advancement for Correction of Upper Eyelid Ptosis: A Systematic Literature Review. 38
29958196 2018
31
Universal ocular screening of 481 infants using wide-field digital imaging system. 38
30376816 2018
32
Efficacy of Inverted "V" Release Surgery in the Correction of a Special Type of Epicanthus. 38
29992338 2018
33
The Prevalence of Lower Eyelid Fornix Fat Prolapse: A Diagnostic Measure of Involutional Entropion. 38
30479717 2018
34
Deepening Fornix Technique Using Central Split-Medium Thickness Skin Graft to Treat Contracted Anophthalmic Sockets. 38
29742574 2018
35
Epidemiology of ocular disorders presumed to be inherited in three small Italian dog breeds in Italy. 38
29284193 2018
36
Management of Severe Cicatricial Entropion With Labial Mucous Membrane Graft in Cicatricial Ocular Surface Disorders. 38
29762330 2018
37
Association of Involutional Lower Eyelid Entropion with Reduced Upper Eyelid Position Relative to the Corneal Light Reflex: Quantification of Facial Asymmetry. 38
29342029 2018
38
Open reduction of zygoma fractures with the extended transconjunctival approach and T-bar screw reduction. 38
30037192 2018
39
Long-Term Outcomes of Acellular Dermal Allograft as a Tarsal Substitute in the Reconstruction of Extensive Eyelid Defects. 38
29521763 2018
40
Lateral tarsal strip versus Bick's procedure in correction of eyelid malposition. 38
29463864 2018
41
Upper eyelid platinum weight placement for the treatment of paralytic lagophthalmos: A new plane between the inner septum and the levator aponeurosis. 38
29788690 2018
42
Utility of PROSE Device in the Management of Complex Oculoplastic Pathology. 38
28542033 2018
43
A review of scoring systems for ocular involvement in chronic cutaneous bullous diseases. 38
29789014 2018
44
Scleral Contact Lenses in an Academic Oculoplastics Clinic: Epidemiology and Emerging Considerations. 38
28538612 2018
45
Lower eyelid entropion repair with retractor mobilization and insertion onto the anterior surface of the tarsal plate. 38
29040033 2018
46
Entropion and ectropion repair: a snapshot of surgical practice in the United Kingdom. 38
29053043 2018
47
Correction of upper eyelid entropion: Modified techniques are most welcome. 38
29380775 2018
48
"The influence of orbital vector on involutional entropion and ectropion". 38
28853964 2018
49
Upper eyelid levator-recession and anterior lamella repositioning through the grey-line: Avoiding a skin-crease incision. 38
29380774 2018
50
Reactivation of herpes simplex viral keratitis following the botulinum toxin injection. 38
29380788 2018

Variations for Entropion

ClinVar genetic disease variations for Entropion:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 46;XY;inv(6)(p22q13)dn inversion Pathogenic

Expression for Entropion

Search GEO for disease gene expression data for Entropion.

Pathways for Entropion

GO Terms for Entropion

Biological processes related to Entropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 8.62 PRCD MYO3B

Sources for Entropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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