EMS
MCID: ESN002
MIFTS: 40

Eosinophilia-Myalgia Syndrome (EMS)

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 73 20 54 44 15 17 70
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 20
Severe Muscle Pain and Abnormally High Eosinophils 20
Eosinophilia Myalgia Syndrome 12
L-Tryptophan Induced Ems 20
Ems 20

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 34 710.5
MeSH 44 D016603
SNOMED-CT 67 95416007
UMLS 70 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

Disease Ontology : 12 A hypereosinophilic syndrome that is characterized by subacute onset of myalgias and peripheral eosinophilia, followed by chronic neuropathy and skin induration.

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to hypereosinophilic syndrome and toxic oil syndrome, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. The drugs Tryptophan and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Eosinophilia-myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 31.9 IL5 IFNG FIP1L1
2 toxic oil syndrome 31.0 IL5 IFNG IDO1 AHR
3 eosinophilic fasciitis 30.8 IL5 IFNG BMP6 AHR
4 myositis 30.6 IFNG HLA-DRB1 HLA-DQA1
5 neuritis 30.4 TGFB1 IFNG HLA-DRB1 HLA-DQA1
6 keloid disorder 30.3 TGFB1 BMP6
7 trichinosis 30.2 RNASE2 IL5
8 connective tissue disease 30.2 IFNG HLA-DRB1 HLA-DQA1 BMP6
9 interstitial lung disease 30.1 TGFB1 IL5 IFNG
10 chronic fatigue syndrome 30.1 IL5 IFNG CRH
11 lung disease 29.8 TGFB1 IL5 IFNG BMP6
12 autoimmune disease 29.0 TGFB1 IL5 IFNG IDO1 HLA-DRB1 HLA-DQA1
13 fasciitis 10.8
14 systemic scleroderma 10.7
15 exanthem 10.6
16 myopathy 10.6
17 polyneuropathy 10.5
18 peripheral nervous system disease 10.5
19 neuropathy 10.4
20 alopecia 10.4
21 localized scleroderma 10.4
22 fibromyalgia 10.3
23 atopic keratoconjunctivitis 10.3 IL5 IFNG
24 beryllium disease 10.3 TGFB1 HLA-DRB1
25 spotted fever rickettsiosis 10.3 IFNG IDO1
26 scleroderma, familial progressive 10.3
27 skin disease 10.3
28 juvenile myasthenia gravis 10.3 TGFB1 HLA-DRB1
29 pustulosis palmaris et plantaris 10.3 TGFB1 IL5
30 nickel allergic contact dermatitis 10.3 IL5 IFNG
31 mansonelliasis 10.3 IL5 IFNG
32 mucocutaneous leishmaniasis 10.2 IL5 IFNG
33 osteonecrosis of the jaw 10.2 TGFB1 HLA-DRB1
34 pemphigoid gestationis 10.2 IL5 HLA-DRB1
35 primary adrenal insufficiency 10.2 HLA-DRB1 HLA-DQA1
36 clonorchiasis 10.2 TGFB1 IFNG
37 polymyositis 10.2
38 myositis fibrosa 10.2
39 cardiac sarcoidosis 10.2 IL5 IFNG
40 focal epithelial hyperplasia 10.2 HLA-DRB1 HLA-DQA1
41 urinary schistosomiasis 10.2 IL5 IFNG
42 berylliosis 10.2 IFNG HLA-DRB1
43 podoconiosis 10.2 HLA-DRB1 HLA-DQA1
44 idiopathic nephrotic syndrome 10.2 TGFB1 HLA-DRB1
45 scleritis 10.2 IL5 IFNG
46 latex allergy 10.2 IL5 IFNG
47 ocular cicatricial pemphigoid 10.2 TGFB1 HLA-DRB1
48 idiopathic neutropenia 10.2 TGFB1 HLA-DRB1
49 ascaris lumbricoides infection 10.2 IL5 IFNG
50 loeffler syndrome 10.2 IL5 FIP1L1

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle weakness; myalgia; muscle cramp; muscle rigidity; muscle spasticity

GenomeRNAi Phenotypes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-104 9.78 FIP1L1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.78 TGFB1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.78 AHR TGFB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.78 AHR
5 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.78 AHR
6 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.78 AHR
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 AHR
8 Increased shRNA abundance (Z-score > 2) GR00366-A-162 9.78 AHR FIP1L1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 TGFB1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-171 9.78 AHR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-175 9.78 AHR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.78 TGFB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.78 AHR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.78 TGFB1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.78 AHR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.78 FIP1L1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.78 TGFB1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.78 AHR FIP1L1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.78 AHR FIP1L1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 FIP1L1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-71 9.78 TGFB1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.78 FIP1L1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-77 9.78 TGFB1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.78 FIP1L1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.78 FIP1L1

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tryptophan Approved, Nutraceutical, Withdrawn 73-22-3 6305
2 5-hydroxytryptophan

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 L-5-Hydroxy-Tryptophan-Related Eosinophilia-Myalgia Syndrome (EMS): Clinical Patient Evaluation Completed NCT00001918

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

40
Lung, Heart, Skin, Spinal Cord, Skeletal Muscle, Pituitary, Neutrophil

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 491)
# Title Authors PMID Year
1
1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant. 54 61
8132737 1994
2
Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome. 61 54
2236076 1990
3
Clinical perspective and practices on pleural effusions in chronic systemic inflammatory diseases. 61
33447289 2020
4
Chemical exposure-induced systemic fibrosing disorders: Novel insights into systemic sclerosis etiology and pathogenesis. 61
33059296 2020
5
Pharmacovigilance and drug-induced rare diseases: Strengths of the French Network of Regional Pharmacovigilance Centres. 61
32113688 2020
6
[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia]. 61
30937528 2019
7
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. 61
29800716 2018
8
Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome. 61
29037509 2018
9
Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion. 61
28074748 2016
10
Prediction of drug-induced eosinophilia adverse effect by using SVM and naïve Bayesian approaches. 61
26044554 2016
11
[Eosinophilic fasciitis (Shulman's disease): Diagnostic and therapeutic review]. 61
26385125 2015
12
Eosinophilia in Rheumatologic/Vascular Disorders. 61
26209895 2015
13
[Eosinophilic fasciitis]. 61
25897110 2015
14
Eosinophilia-myalgia syndrome induced by excessive L-tryptophan intake from cashew nuts. 61
32288933 2014
15
Immunohistochemical studies of the kynurenine pathway in morphea. 61
24385714 2013
16
Effects and side effects associated with the non-nutritional use of tryptophan by humans. 61
23077193 2012
17
Eosinophilic fasciitis (Shulman disease). 61
23040360 2012
18
Severe eosinophilic syndrome associated with the use of probiotic supplements: a new entity? 61
23259129 2012
19
Environmental- and injury-related epidemic-assistance investigations, 1946-2005. 61
22135395 2011
20
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan. 61
21702023 2011
21
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? 61
19941898 2010
22
[Skin manifestations of toxic syndrome due to denatured rapeseed oil]. 61
20038361 2009
23
[Eosinophilia myalgia syndrome (EMS) caused by L-tryptophan product and toxic oil syndrome (TOS) caused by denatured rape-seed oil]. 61
20065617 2009
24
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms. 61
19790128 2009
25
[Shulman's syndrome (eosinophilic fasciitis)]. 61
19300913 2009
26
Neuromuscular disorders associated with apical hypertrophic cardiomyopathy. 61
19317303 2009
27
Activity of certain drugs in inducing of inflammatory myopathies with cutaneous manifestations. 61
18613806 2008
28
[Current differential diagnosis of hypereosinophilic syndrome]. 61
18666600 2007
29
[Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake]. 61
18200378 2007
30
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. 61
17892268 2007
31
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. 61
17806156 2007
32
[Diagnostic problems in eosinophilic fasciitis]. 61
17424924 2006
33
Is the L-tryptophan metabolite quinolinic acid responsible for eosinophilic fasciitis? 61
16820992 2006
34
Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report. 61
16838769 2006
35
Drug-, toxin-, and radiation therapy-induced eosinophilic pneumonia. 61
16612770 2006
36
Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. 61
16023217 2006
37
[Application of multi-slice spiral CT in the diagnosis of pulmonary hypertension]. 61
16548187 2006
38
Does 5-hydroxytryptophan cause acute and chronic toxic perturbations in rats? 61
20021026 2006
39
A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. 61
16307217 2005
40
Miliary tuberculosis in a patient with eosinophilic fasciitis. 61
15678644 2005
41
Review article toxic oil syndrome: review of immune aspects of the disease. 61
18958659 2005
42
Safety of 5-hydroxy-L-tryptophan. 61
15068828 2004
43
[Diagnostic performance of echocardiography in the follow-up of patients with toxic oil syndrome]. 61
14670272 2003
44
Non-L-tryptophan related eosinophilia-myalgia syndrome with hypoproteinemia and hypoalbuminemia. 61
12610828 2003
45
Structural characterization of a case-implicated contaminant, "Peak X," in commercial preparations of 5-hydroxytryptophan. 61
12508395 2003
46
Scleroderma-like cutaneous syndromes. 61
11890876 2002
47
Tryptophan and 5-hydroxytryptophan for depression. 61
11869656 2002
48
L-tryptophan contaminant 'peak E' induces the release of IL-5 and IL-10 by peripheral blood mononuclear cells from patients with functional somatic syndromes. 61
11703359 2001
49
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. 61
11606145 2001
50
The toxic oil syndrome: 20 years on. 61
11501225 2001

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 TGFB1 IL5 IFNG HLA-DRB1 HLA-DQA1
2
Show member pathways
12.03 TGFB1 IL5 IFNG BMP6
3
Show member pathways
11.98 TGFB1 IFNG HLA-DRB1 HLA-DQA1
4
Show member pathways
11.97 TGFB1 IL5 IFNG HLA-DRB1 HLA-DQA1 AHR
5 11.92 TGFB1 IFNG HLA-DRB1 HLA-DQA1
6 11.68 IL5 HLA-DRB1 HLA-DQA1
7 11.64 TGFB1 IFNG BMP6
8 11.56 IL5 IFNG AHR
9 11.43 TGFB1 IFNG HLA-DRB1 HLA-DQA1
10 11.29 TGFB1 IFNG AHR
11 11 IL5 IFNG AHR
12 10.96 IL5 IFNG
13 10.88 TGFB1 IFNG HLA-DRB1
14 10.62 TGFB1 IL5
15 10.39 TGFB1 IL5 IFNG HLA-DRB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 TGFB1 RNASE2 IL5 IFNG HLA-DRB1 CRH
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DRB1 HLA-DQA1
3 MHC class II protein complex GO:0042613 8.96 HLA-DRB1 HLA-DQA1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.86 TGFB1 IFNG CRH BMP6
2 positive regulation of cell proliferation GO:0008284 9.77 TGFB1 IL5 IFNG CRH BMP6
3 immune response GO:0006955 9.72 IL5 IFNG HLA-DRB1 HLA-DQA1 BMP6
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 TGFB1 IL5 BMP6
5 female pregnancy GO:0007565 9.61 TGFB1 IDO1 CRH
6 interferon-gamma-mediated signaling pathway GO:0060333 9.58 IFNG HLA-DRB1 HLA-DQA1
7 cellular response to dexamethasone stimulus GO:0071549 9.57 TGFB1 CRH
8 positive regulation of protein phosphorylation GO:0001934 9.56 TGFB1 IFNG HLA-DRB1 CRH
9 negative regulation of interleukin-17 production GO:0032700 9.55 TGFB1 IFNG
10 macrophage differentiation GO:0030225 9.54 IFNG HLA-DRB1
11 positive regulation of SMAD protein signal transduction GO:0060391 9.52 TGFB1 BMP6
12 regulation of regulatory T cell differentiation GO:0045589 9.51 TGFB1 IFNG
13 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.49 HLA-DRB1 HLA-DQA1
14 positive regulation of vascular permeability GO:0043117 9.48 TGFB1 BMP6
15 inflammatory response GO:0006954 9.35 TGFB1 IL5 IDO1 CRH BMP6
16 negative regulation of T cell proliferation GO:0042130 9.33 TGFB1 IDO1 HLA-DRB1
17 response to immobilization stress GO:0035902 8.8 TGFB1 HNMT CRH

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 TGFB1 IL5 BMP6
2 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQA1
3 cytokine activity GO:0005125 8.92 TGFB1 IL5 IFNG BMP6

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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