EMS
MCID: ESN002
MIFTS: 48

Eosinophilia-Myalgia Syndrome (EMS)

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 53 55 44 15 73
Ems 53 3
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 53
Severe Muscle Pain and Abnormally High Eosinophils 53
Eosinophilia Myalgia Syndrome 12
Eosinophiliamyalgia Syndrome 76
L-Tryptophan Induced Ems 53

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 35 710.5
MeSH 44 D016603
SNOMED-CT 68 95416007
UMLS 73 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

CDC : 3 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as ems, is related to toxic oil syndrome and eosinophilic fasciitis, and has symptoms including muscle weakness, myalgia and muscle rigidity. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs 5-hydroxytryptophan and Tryptophan have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Wikipedia : 76 Eosinophilia�??myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 toxic oil syndrome 31.2 IFNG IL5
2 eosinophilic fasciitis 30.5 BMP6 IFNG IL5
3 fasciitis 10.7
4 fibromyalgia 10.4
5 polyneuropathy 10.3
6 neuropathy 10.3
7 pseudoxanthoma elasticum 10.2
8 pulmonary hypertension 10.2
9 myopathy 10.2
10 demyelinating polyneuropathy 10.2
11 peripheral nervous system disease 10.2
12 perimyositis 10.2
13 norwegian scabies 10.1 IL5 TGFB1
14 cephalosporin allergy 10.1 IFNG IL5
15 nickel allergic contact dermatitis 10.1 IFNG IL5
16 allergic contact dermatitis 10.1 IFNG IL5
17 contact dermatitis 10.1 IFNG IL5
18 pustulosis palmaris et plantaris 10.1 IL5 TGFB1
19 scleritis 10.1 IFNG IL5
20 atopic keratoconjunctivitis 10.1 IFNG IL5
21 keratoconjunctivitis 10.1 IFNG IL5
22 conjunctivitis 10.1 IFNG IL5
23 cardiac sarcoidosis 10.1 IFNG IL5
24 ascaris lumbricoides infection 10.1 IFNG IL5
25 urinary schistosomiasis 10.1 IFNG IL5
26 folliculitis 10.1 IFNG IL5
27 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IFNG IL5
28 pemphigoid gestationis 10.1 HLA-DRB1 IL5
29 allergic conjunctivitis 10.1 IFNG IL5
30 clonorchiasis 10.1 IFNG TGFB1
31 paracoccidioidomycosis 10.1 IFNG IL5
32 chronic active epstein-barr virus infection 10.1 IFNG TGFB1
33 autoimmune disease of gastrointestinal tract 10.1 HLA-DQA1 IFNG
34 ige responsiveness, atopic 10.1 IFNG IL5
35 beryllium disease 10.1 HLA-DQA1 HLA-DRB1
36 hirata disease 10.1 HLA-DQA1 HLA-DRB1
37 sympathetic ophthalmia 10.1 HLA-DQA1 HLA-DRB1
38 filariasis 10.1 IFNG IL5
39 esophagitis 10.1 IL5 TGFB1
40 juvenile myasthenia gravis 10.1 HLA-DRB1 TGFB1
41 food allergy 10.1 IFNG IL5
42 acute disseminated encephalomyelitis 10.1 HLA-DQA1 HLA-DRB1
43 osteonecrosis of the jaw 10.1 HLA-DRB1 TGFB1
44 upper respiratory tract disease 10.1 IFNG IL5
45 focal epithelial hyperplasia 10.1 HLA-DQA1 HLA-DRB1
46 rheumatic fever 10.1 HLA-DQA1 HLA-DRB1
47 cutaneous leishmaniasis 10.0 IFNG IL5
48 berylliosis 10.0 HLA-DRB1 IFNG
49 chronic beryllium disease 10.0 HLA-DRB1 IFNG
50 ocular cicatricial pemphigoid 10.0 HLA-DRB1 TGFB1

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle weakness, myalgia, muscle rigidity, muscle cramp, muscle spasticity

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 5-hydroxytryptophan
2 Tryptophan

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 L-5-HTP-Related EMS Completed NCT00001918
2 Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical Trials Completed NCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

41
Skin, Heart, Lung, Brain, Spinal Cord, Skeletal Muscle, Bone

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 1284)
# Title Authors Year
1
Sexual harassment and its relationship with depressive symptoms: A nationwide study of Korean EMS providers. ( 30507041 )
2019
2
Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome. ( 29037509 )
2018
3
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. ( 29800716 )
2018
4
Gender Differences in the Quality of EMS Care Nationwide for Chest Pain and Out-of- Hospital Cardiac Arrest. ( 30545703 )
2018
5
Feasibility of Out-of-Hospital Cardiac Arrest Ultrasound by EMS Physicians. ( 30192687 )
2018
6
A potential termination of resuscitation rule for EMS to implement in the field for out-of-hospital cardiac arrest: An observational cohort study. ( 29940294 )
2018
7
Using spatial regression methods to evaluate rural emergency medical services (EMS). ( 30522937 )
2018
8
Emergency call characteristics and EMS dispatcher protocol adherence for possible anaphylaxis. ( 30526221 )
2018
9
The impact of prehospital assessment and EMS transport of acute aortic syndrome patients. ( 29276030 )
2018
10
Measuring a Crisis: Questioning the Use of Naloxone Administrations as a Marker for Opioid Overdoses in a Large U.S. EMS System. ( 29297739 )
2018
11
Excessive Endoplasmic Reticulum Stress Correlates with Impaired Mitochondrial Dynamics, Mitophagy and Apoptosis, in Liver and Adipose Tissue, but Not in Muscles in EMS Horses. ( 29316632 )
2018
12
EMS-induced mutation followed by quizalofop-screening increased lipid productivity in Chlorella sp. ( 29350295 )
2018
13
EMS Physician-Performed Clinical Interventions in the Field. ( 29364735 )
2018
14
The Effect of Methyl-β-cyclodextrin on Apoptosis, Proliferative Activity, and Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells of Horses Suffering from Metabolic Syndrome (EMS). ( 29385746 )
2018
15
Disinfection of an EMS/AHPND strain of Vibrio parahaemolyticus using ozone nanobubbles. ( 29399827 )
2018
16
New Immobilization Guidelines Change EMS Critical Thinking in Older Adults With Spine Trauma. ( 29405797 )
2018
17
The Use of Field Triage in Disaster and Mass Casualty Incidents: A Survey of Current Practices by EMS Personnel. ( 29425472 )
2018
18
The Ethics of Real-Time EMS Direction: Suggested Curricular Content. ( 29441840 )
2018
19
Emergency Medical Service (EMS) Utilization by Syrian Refugees Residing in Ankara, Turkey. ( 29455680 )
2018
20
The dead and the dying - a difficult part of EMS transport: A Swiss cross-sectional study. ( 29485991 )
2018
21
Perceived exertion using two different EMS stretcher systems, report from a Swedish study. ( 29510910 )
2018
22
A Descriptive Analysis of Care Provided by Law Enforcement Prior to EMS Arrival in the United States. ( 29530105 )
2018
23
Determinants of Pediatric EMS Utilization in Children with High-Acuity Conditions. ( 29565717 )
2018
24
Defining Quality in EMS. ( 29595357 )
2018
25
Prehospital Blood Product Administration Opportunities in Ground Transport ALS EMS - A Descriptive Study. ( 29669612 )
2018
26
Humoral and cell-mediated immune responses to influenza vaccination in equine metabolic syndrome (EMS) horses. ( 29678227 )
2018
27
AED use before EMS arrival: When survival becomes a matter of law and system in Italy, which can be improved. ( 29762703 )
2018
28
Development and implementation of a geographical area categorisation method with targeted performance indicators for nationwide EMS in Finland. ( 29764468 )
2018
29
EMS providers do not use FOAM for education. ( 29797111 )
2018
30
Antimutagenic activity of compounds isolated from Ajuga bracteosa Wall ex. Benth against EMS induced mutagenicity in mice. ( 29854582 )
2018
31
Preventing EMS workplace violence: A mixed-methods analysis of insights from assaulted medics. ( 29861309 )
2018
32
Efficacy and Safety of Low Frequency Whole-Body Electromyostimulation (WB-EMS) to Improve Health-Related Outcomes in Non-athletic Adults. A Systematic Review. ( 29875684 )
2018
33
Characterization of the loss-of-function mutant NH101 for yield under phosphate deficiency from EMS-induced mutants of rice variety Nagina22. ( 29957570 )
2018
34
Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses. ( 29977307 )
2018
35
Ten years of EMS Fall Calls in a Community: An Opportunity for Injury Prevention Strategies. ( 30013811 )
2018
36
An EMS-induced new sequence variant, TEMS5032, in the coding region of SRS3 gene leads to shorter grain length in rice (Oryza sativa L.). ( 30014258 )
2018
37
Simulated EMS response times until patients located in public train stations: A geospatial model to improve on-foot accessibility. ( 30077741 )
2018
38
Workplace Incivility Among Nationally Certified EMS Professionals and Associations with Workforce-Reducing Factors and Organizational Culture. ( 30118629 )
2018
39
Videographic Assessment of the Quality of EMS to ED Handoff Communication During Pediatric Resuscitations. ( 30118642 )
2018
40
Burnout and safety outcomes - a cross-sectional nationwide survey of EMS-workers in Germany. ( 30126358 )
2018
41
State of the Evidence for Emergency Medical Services (EMS) Care: The Evolution and Current Methodology of the Prehospital Evidence-Based Practice (PEP) Program. ( 30129435 )
2018
42
Death by Suicide-The EMS Profession Compared to the General Public. ( 30136908 )
2018
43
Innovations in EMS Education. ( 30192684 )
2018
44
The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans. ( 30213539 )
2018
45
Safety of on-scene medical care by EMS nurses in non-transported patients: a prospective, observational study. ( 30217231 )
2018
46
Envelope modulation spectral (EMS) analyses of solo reading and choral reading conditions suggest changes in speech rhythm in adults who stutter. ( 30220404 )
2018
47
Understanding Why Frequent Users of EMS Call 9-1-1: A Grounded Theory Study. ( 30222003 )
2018
48
Whole Genome Characterization of a Few EMS-Induced Mutants of Upland Rice Variety Nagina 22 Reveals a Staggeringly High Frequency of SNPs Which Show High Phenotypic Plasticity Towards the Wild-Type. ( 30233603 )
2018
49
Patient Autonomy and Destination Factors in Emergency Medical Services (EMS) and EMS-Affiliated Mobile Integrated Healthcare/Community Paramedicine Programs. ( 30236348 )
2018
50
EMS naloxone administration as non-fatal opioid overdose surveillance: 6-year outcomes in Marion County, Indiana. ( 30255531 )
2018

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
2
Show member pathways
12.54 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
3
Show member pathways
12.35 HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.24 HLA-DQA1 HLA-DRB1 IFNG
5
Show member pathways
12.14 IFNG IL5 TGFB1
6 12.13 HLA-DQA1 HLA-DRB1 TGFB1
7
Show member pathways
12.09 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
8
Show member pathways
11.94 BMP6 IFNG IL5 TGFB1
9
Show member pathways
11.94 HLA-DQA1 HLA-DRB1 IFNG TGFB1
10 11.88 HLA-DQA1 HLA-DRB1 IFNG TGFB1
11
Show member pathways
11.79 BMP6 IFNG IL5 TGFB1
12 11.66 HLA-DQA1 HLA-DRB1 IL5
13 11.56 BMP6 IFNG TGFB1
14 11.45 IFNG TGFB1
15 11.44 BMP6 TGFB1
16 11.42 IL5 TGFB1
17 11.37 IFNG TGFB1
18 11.35 HLA-DQA1 HLA-DRB1
19 11.29 IFNG TGFB1
20 11.27 IFNG TGFB1
21 11.25 IFNG IL5
22 11.21 HLA-DQA1 HLA-DRB1 IFNG TGFB1
23 11.09 IFNG IL5
24 11.04 IFNG IL5
25 10.94 IFNG IL5
26 10.88 HLA-DRB1 IFNG TGFB1
27 10.39 HLA-DRB1 IFNG IL5 TGFB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 BMP6 CRH IFNG IL5 TGFB1
2 extracellular space GO:0005615 9.55 BMP6 CRH IFNG IL5 TGFB1
3 endocytic vesicle membrane GO:0030666 9.43 HLA-DQA1 HLA-DRB1
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DQA1 HLA-DRB1
5 transport vesicle membrane GO:0030658 9.32 HLA-DQA1 HLA-DRB1
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DQA1 HLA-DRB1
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DRB1
8 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.72 CRH IFNG TGFB1
2 positive regulation of protein phosphorylation GO:0001934 9.65 CRH IFNG TGFB1
3 positive regulation of epithelial cell proliferation GO:0050679 9.63 BMP6 TGFB1
4 cell development GO:0048468 9.62 BMP6 TGFB1
5 regulation of MAPK cascade GO:0043408 9.62 BMP6 TGFB1
6 regulation of signaling receptor activity GO:0010469 9.62 BMP6 IFNG IL5 TGFB1
7 SMAD protein signal transduction GO:0060395 9.61 BMP6 TGFB1
8 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.61 BMP6 TGFB1
9 extrinsic apoptotic signaling pathway GO:0097191 9.6 IFNG TGFB1
10 antigen processing and presentation GO:0019882 9.59 HLA-DQA1 HLA-DRB1
11 negative regulation of T cell proliferation GO:0042130 9.58 HLA-DRB1 TGFB1
12 positive regulation of protein secretion GO:0050714 9.58 BMP6 TGFB1
13 positive regulation of bone mineralization GO:0030501 9.57 BMP6 TGFB1
14 cellular response to dexamethasone stimulus GO:0071549 9.56 CRH TGFB1
15 inflammatory response GO:0006954 9.56 BMP6 CRH IL5 TGFB1
16 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.54 CRH HLA-DRB1
17 positive regulation of protein complex assembly GO:0031334 9.52 IFNG TGFB1
18 response to immobilization stress GO:0035902 9.51 CRH TGFB1
19 protein import into nucleus, translocation GO:0000060 9.49 IFNG TGFB1
20 regulation of regulatory T cell differentiation GO:0045589 9.46 IFNG TGFB1
21 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.43 HLA-DQA1 HLA-DRB1
22 negative regulation of interleukin-17 production GO:0032700 9.4 IFNG TGFB1
23 positive regulation of SMAD protein signal transduction GO:0060391 9.37 BMP6 TGFB1
24 positive regulation of cell proliferation GO:0008284 9.35 BMP6 CRH IFNG IL5 TGFB1
25 interferon-gamma-mediated signaling pathway GO:0060333 9.33 HLA-DQA1 HLA-DRB1 IFNG
26 immune response GO:0006955 9.02 BMP6 HLA-DQA1 HLA-DRB1 IFNG IL5

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 BMP6 IL5 TGFB1
2 transforming growth factor beta receptor binding GO:0005160 9.32 BMP6 TGFB1
3 peptide antigen binding GO:0042605 9.26 HLA-DQA1 HLA-DRB1
4 MHC class II receptor activity GO:0032395 8.96 HLA-DQA1 HLA-DRB1
5 cytokine activity GO:0005125 8.92 BMP6 IFNG IL5 TGFB1

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....