EMS
MCID: ESN002
MIFTS: 48

Eosinophilia-Myalgia Syndrome (EMS)

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 77 54 56 45 15 17 74
Ems 54 3
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 54
Severe Muscle Pain and Abnormally High Eosinophils 54
Eosinophilia Myalgia Syndrome 12
L-Tryptophan Induced Ems 54

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 36 710.5
MeSH 45 D016603
SNOMED-CT 69 95416007
UMLS 74 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

CDC : 3 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as ems, is related to toxic oil syndrome and eosinophilic fasciitis, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs 5-hydroxytryptophan and Tryptophan have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and brain, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 77 Eosinophilia–myalgia syndrome (EMS) is an incurable and sometimes fatal flu-like neurological condition... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 toxic oil syndrome 30.9 AHR IFNG IL5
2 eosinophilic fasciitis 30.7 AHR IFNG IL5
3 fasciitis 10.7
4 fibromyalgia 10.4
5 polyneuropathy 10.3
6 neuropathy 10.3
7 norwegian scabies 10.2 IL5 TGFB1
8 pustulosis palmaris et plantaris 10.2 IL5 TGFB1
9 cephalosporin allergy 10.2 IFNG IL5
10 nickel allergic contact dermatitis 10.2 IFNG IL5
11 allergic contact dermatitis 10.2 IFNG IL5
12 contact dermatitis 10.2 IFNG IL5
13 scleritis 10.2 IFNG IL5
14 atopic keratoconjunctivitis 10.2 IFNG IL5
15 keratoconjunctivitis 10.2 IFNG IL5
16 conjunctivitis 10.2 IFNG IL5
17 pseudoxanthoma elasticum 10.2
18 pulmonary hypertension 10.2
19 myopathy 10.2
20 demyelinating polyneuropathy 10.2
21 peripheral nervous system disease 10.2
22 perimyositis 10.2
23 multicentric castleman disease 10.2 IFNG IL5
24 urinary schistosomiasis 10.2 IFNG IL5
25 schistosomiasis 10.2 IFNG IL5
26 clonorchiasis 10.2 IFNG TGFB1
27 folliculitis 10.2 IFNG IL5
28 tuberculoid leprosy 10.2 IFNG TGFB1
29 chronic active epstein-barr virus infection 10.2 IFNG TGFB1
30 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IFNG IL5
31 pemphigoid gestationis 10.2 HLA-DRB1 IL5
32 esophagitis 10.2 IL5 TGFB1
33 nonspecific interstitial pneumonia 10.1 IFNG TGFB1
34 allergic conjunctivitis 10.1 IFNG IL5
35 paracoccidioidomycosis 10.1 IFNG IL5
36 juvenile myasthenia gravis 10.1 HLA-DRB1 TGFB1
37 ige responsiveness, atopic 10.1 IFNG IL5
38 filariasis 10.1 IFNG IL5
39 osteonecrosis of the jaw 10.1 HLA-DRB1 TGFB1
40 autoimmune disease of gastrointestinal tract 10.1 HLA-DQA1 IFNG
41 beryllium disease 10.1 HLA-DQA1 HLA-DRB1
42 food allergy 10.1 IFNG IL5
43 hirata disease 10.1 HLA-DQA1 HLA-DRB1
44 upper respiratory tract disease 10.1 IFNG IL5
45 sympathetic ophthalmia 10.1 HLA-DQA1 HLA-DRB1
46 cutaneous leishmaniasis 10.1 IFNG IL5
47 ocular cicatricial pemphigoid 10.1 HLA-DRB1 TGFB1
48 idiopathic neutropenia 10.1 HLA-DRB1 TGFB1
49 berylliosis 10.1 HLA-DRB1 IFNG
50 chronic beryllium disease 10.1 HLA-DRB1 IFNG

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 AHR CRH HLA-DQA1 IFNG IL5 TGFB1
2 endocrine/exocrine gland MP:0005379 9.77 AHR CRH HLA-DQA1 IFNG TGFB1
3 immune system MP:0005387 9.73 AHR CRH HLA-DQA1 IFNG IL5 TGFB1
4 liver/biliary system MP:0005370 9.55 AHR CRH IFNG IL5 TGFB1
5 neoplasm MP:0002006 9.26 AHR IFNG IL5 TGFB1
6 respiratory system MP:0005388 9.02 AHR CRH IFNG IL5 TGFB1

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 5-hydroxytryptophan
2 Tryptophan

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 L-5-HTP-Related EMS Completed NCT00001918
2 Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical Trials Completed NCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

42
Skin, Heart, Brain, Spinal Cord, Skeletal Muscle, Neutrophil, T Cells

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 344)
# Title Authors Year
1
Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome. ( 29037509 )
2018
2
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. ( 29800716 )
2018
3
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan. ( 21702023 )
2011
4
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? ( 19941898 )
2010
5
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms. ( 19790128 )
2009
6
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. ( 17892268 )
2007
7
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. ( 17806156 )
2007
8
Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report. ( 16838769 )
2006
9
A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. ( 16307217 )
2005
10
Non-L-tryptophan related eosinophilia-myalgia syndrome with hypoproteinemia and hypoalbuminemia. ( 12610828 )
2003
11
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. ( 11606145 )
2001
12
Eosinophilic cholecystitis as a possible late manifestation of the eosinophilia-myalgia syndrome. ( 11147758 )
2000
13
Eosinophilia-myalgia syndrome case-associated contaminants in commercially available 5-hydroxytryptophan. ( 10721089 )
1999
14
Is there any relationship between eosinophilia myalgia syndrome (EMS) and fibromyalgia syndrome (FMS)? An analysis of clinical and immunological data. ( 10721092 )
1999
15
Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. ( 10606395 )
1999
16
Eosinophilia-myalgia syndrome and giant cell myocarditis: a case report and therapeutic approach. ( 11720607 )
1999
17
Structural characterization of case-associated contaminants peak C and FF in L-tryptophan implicated in eosinophilia-myalgia syndrome. ( 10721088 )
1999
18
Pain, fatigue, and sleep in eosinophilia-myalgia syndrome: relationship to neuropsychological performance. ( 9706542 )
1998
19
Structural characterization of contaminants found in commercial preparations of melatonin: similarities to case-related compounds from L-tryptophan associated with eosinophilia-myalgia syndrome. ( 9544622 )
1998
20
On-line HPLC-tandem mass spectrometry structural characterization of case-associated contaminants of L-tryptophan implicated with the onset of eosinophilia myalgia syndrome. ( 9817085 )
1998
21
Rapid HPLC screening method for contaminants found in implicated L-tryptophan associated with eosinophilia myalgia syndrome and adulterated rapeseed oil associated with toxic oil syndrome. ( 9787895 )
1998
22
L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. ( 9858150 )
1998
23
Neurologic, MR imaging, and MR spectroscopic findings in eosinophilia myalgia syndrome. ( 9802492 )
1998
24
Elevated L-kynurenine level and its normalization by prednisolone in a patient with eosinophilia-myalgia syndrome. ( 9037890 )
1997
25
Increased activity of the alpha 1(I) procollagen promoter in skin fibroblasts from patients with chronic eosinophilia-myalgia syndrome. ( 9076948 )
1997
26
The eosinophilia myalgia syndrome: to be or not to be. ( 9213375 )
1997
27
Eosinophilia-myalgia syndrome: description of an unusual case. ( 9196880 )
1997
28
Eosinophilia myalgia syndrome. ( 9213377 )
1997
29
Eosinophilia-myalgia syndrome: opportunities realized and missed. ( 9195545 )
1997
30
On-line HPLC-tandem mass spectrometry analysis of contaminants of L-tryptophan associated with the onset of the eosinophilia-myalgia syndrome. ( 9295237 )
1997
31
Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders. ( 9375286 )
1997
32
Eosinophilia-myalgia syndrome: selective cognitive impairment, longitudinal effects, and neuroimaging findings. ( 9408106 )
1997
33
Clinical features of eosinophilia myalgia syndrome and related disorders. ( 8906285 )
1996
34
Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. ( 8895181 )
1996
35
Delayed onset of skin fibrosis after the ingestion of eosinophilia-myalgia syndrome-associated L-tryptophan. ( 8708033 )
1996
36
Cognitive deficits in a murine model of the eosinophilia-myalgia syndrome: a preliminary report. ( 8888024 )
1996
37
A contaminant of L-tryptophan enhances expression of dermal collagen in a murine model of eosinophilia myalgia syndrome. ( 8863345 )
1996
38
Pathophysiology of the eosinophilia-myalgia syndrome. ( 8895179 )
1996
39
The eosinophilia-myalgia syndrome: what we know, what we think we know, and what we need to know. ( 8895175 )
1996
40
1995 Bailey K. Ashford lecture. Public health lessons from two catastrophic epidemics: the toxic oil syndrome and the eosinophilia-myalgia syndrome. ( 8744866 )
1996
41
Eosinophilia-Myalgia Syndrome: Review and Reappraisal of Clinical, Epidemiologic and Animal Studies Symposium. Washington, D.C., USA, December 7-8, 1994. Proceedings. ( 9053528 )
1996
42
Fibromyalgia, psychiatric disorders, and assessment of the longterm outcome of eosinophilia-myalgia syndrome. ( 8895180 )
1996
43
Eosinophilia-myalgia syndrome: patient status 2-4 years after onset. ( 8895178 )
1996
44
A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome. ( 8906290 )
1996
45
Diagnostic bias in clinical decision making: an example of L-tryptophan and the diagnosis of eosinophilia-myalgia syndrome. ( 8970044 )
1996
46
Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. ( 8895182 )
1996
47
Persistent microvasculopathy in chronic eosinophilia-myalgia syndrome. ( 8906289 )
1996
48
Eosinophilia-myalgia syndrome among the non-L-tryptophan users and pre-epidemic cases. ( 8895159 )
1996
49
Animal models of the eosinophilia-myalgia syndrome. ( 8895185 )
1996
50
Eosinophilia-myalgia syndrome. Status of patients at onset and after four years of disease. ( 8906291 )
1996

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
2
Show member pathways
12.57 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
3
Show member pathways
12.35 HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.23 HLA-DQA1 HLA-DRB1 IFNG
5
Show member pathways
12.13 IFNG IL5 TGFB1
6 12.05 HLA-DQA1 HLA-DRB1 TGFB1
7
Show member pathways
11.98 IFNG IL5 TGFB1
8
Show member pathways
11.98 HLA-DQA1 HLA-DRB1 IFNG TGFB1
9 11.92 HLA-DQA1 HLA-DRB1 IFNG TGFB1
10
Show member pathways
11.79 IFNG IL5 TGFB1
11 11.66 HLA-DQA1 HLA-DRB1 IL5
12
Show member pathways
11.64 AHR HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
13 11.56 AHR IFNG IL5
14 11.49 HLA-DQA1 HLA-DRB1
15 11.48 IFNG TGFB1
16 11.45 IFNG TGFB1
17 11.44 HLA-DQA1 HLA-DRB1
18 11.42 IL5 TGFB1
19 11.42 HLA-DQA1 HLA-DRB1 IFNG TGFB1
20 11.37 IFNG TGFB1
21 11.31 AHR IFNG TGFB1
22 11.27 IFNG TGFB1
23 11.24 IFNG IL5
24 11.08 IFNG IL5
25 11 AHR IFNG IL5
26 10.94 IFNG IL5
27 10.88 HLA-DRB1 IFNG TGFB1
28 10.72 HLA-DRB1 IFNG IL5 TGFB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.37 HLA-DQA1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQA1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.26 HLA-DQA1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQA1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DRB1
6 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.74 CRH IFNG TGFB1
2 inflammatory response GO:0006954 9.73 CRH IL5 TGFB1
3 negative regulation of gene expression GO:0010629 9.67 CRH IFNG TGFB1
4 positive regulation of cell proliferation GO:0008284 9.62 CRH IFNG IL5 TGFB1
5 positive regulation of protein phosphorylation GO:0001934 9.58 CRH IFNG TGFB1
6 extrinsic apoptotic signaling pathway GO:0097191 9.55 IFNG TGFB1
7 antigen processing and presentation GO:0019882 9.54 HLA-DQA1 HLA-DRB1
8 negative regulation of T cell proliferation GO:0042130 9.52 HLA-DRB1 TGFB1
9 cellular response to dexamethasone stimulus GO:0071549 9.51 CRH TGFB1
10 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.48 CRH HLA-DRB1
11 positive regulation of protein complex assembly GO:0031334 9.46 IFNG TGFB1
12 immune response GO:0006955 9.46 HLA-DQA1 HLA-DRB1 IFNG IL5
13 response to immobilization stress GO:0035902 9.43 CRH TGFB1
14 regulation of regulatory T cell differentiation GO:0045589 9.37 IFNG TGFB1
15 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQA1 HLA-DRB1
16 negative regulation of interleukin-17 production GO:0032700 8.96 IFNG TGFB1
17 interferon-gamma-mediated signaling pathway GO:0060333 8.8 HLA-DQA1 HLA-DRB1 IFNG

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQA1 HLA-DRB1
2 cytokine activity GO:0005125 9.13 IFNG IL5 TGFB1
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DRB1

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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