MCID: ESN002
MIFTS: 50

Eosinophilia-Myalgia Syndrome

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 77 54 56 45 15 17 74
Ems 54 3
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 54
Severe Muscle Pain and Abnormally High Eosinophils 54
Eosinophilia Myalgia Syndrome 12
L-Tryptophan Induced Ems 54

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 36 710.5
MeSH 45 D016603
SNOMED-CT 69 95416007
UMLS 74 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

CDC : 3 Emergency medical services (EMS) workers provide pre-hospital emergency medical care. Their duties create an inherent risk for on-the-job injuries and illnesses. Research shows that EMS workers have high rates of fatal injuries and nonfatal injuries and illnesses.

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as ems, is related to eosinophilic fasciitis and toxic oil syndrome, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Tryptophan and 5-hydroxytryptophan have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Eosinophilia–myalgia syndrome is an incurable and sometimes fatal flu-like neurological condition linked... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 eosinophilic fasciitis 31.1 IFNG IL5
2 toxic oil syndrome 31.0 IDO1 IFNG IL5
3 hypereosinophilic syndrome 11.0
4 fasciitis 10.7
5 fibromyalgia 10.4
6 polyneuropathy 10.3
7 neuropathy 10.3
8 norwegian scabies 10.2 IL5 TGFB1
9 pustulosis palmaris et plantaris 10.2 IL5 TGFB1
10 cephalosporin allergy 10.2 IFNG IL5
11 nickel allergic contact dermatitis 10.2 IFNG IL5
12 allergic contact dermatitis 10.2 IFNG IL5
13 contact dermatitis 10.2 IFNG IL5
14 scleritis 10.2 IFNG IL5
15 atopic keratoconjunctivitis 10.2 IFNG IL5
16 keratoconjunctivitis 10.2 IFNG IL5
17 conjunctivitis 10.2 IFNG IL5
18 pseudoxanthoma elasticum 10.2
19 pulmonary hypertension 10.2
20 myopathy 10.2
21 demyelinating polyneuropathy 10.2
22 peripheral nervous system disease 10.2
23 perimyositis 10.2
24 multicentric castleman disease 10.2 IFNG IL5
25 urinary schistosomiasis 10.2 IFNG IL5
26 schistosomiasis 10.2 IFNG IL5
27 folliculitis 10.2 IFNG IL5
28 clonorchiasis 10.2 IFNG TGFB1
29 tuberculoid leprosy 10.2 IFNG TGFB1
30 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IFNG IL5
31 esophagitis 10.2 IL5 TGFB1
32 pemphigoid gestationis 10.2 HLA-DRB1 IL5
33 nonspecific interstitial pneumonia 10.2 IFNG TGFB1
34 allergic conjunctivitis 10.1 IFNG IL5
35 paracoccidioidomycosis 10.1 IFNG IL5
36 ige responsiveness, atopic 10.1 IFNG IL5
37 juvenile myasthenia gravis 10.1 HLA-DRB1 TGFB1
38 filariasis 10.1 IFNG IL5
39 autoimmune disease of gastrointestinal tract 10.1 HLA-DQA1 IFNG
40 osteonecrosis of the jaw 10.1 HLA-DRB1 TGFB1
41 food allergy 10.1 IFNG IL5
42 beryllium disease 10.1 HLA-DQA1 HLA-DRB1
43 upper respiratory tract disease 10.1 IFNG IL5
44 hirata disease 10.1 HLA-DQA1 HLA-DRB1
45 cutaneous leishmaniasis 10.1 IFNG IL5
46 sympathetic ophthalmia 10.1 HLA-DQA1 HLA-DRB1
47 ocular cicatricial pemphigoid 10.1 HLA-DRB1 TGFB1
48 idiopathic neutropenia 10.1 HLA-DRB1 TGFB1
49 aspergillosis 10.1 IFNG IL5
50 acute disseminated encephalomyelitis 10.1 HLA-DQA1 HLA-DRB1

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

MGI Mouse Phenotypes related to Eosinophilia-Myalgia Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CRH HLA-DQA1 IDO1 IFNG IL5 TGFB1
2 immune system MP:0005387 9.1 CRH HLA-DQA1 IDO1 IFNG IL5 TGFB1

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Tryptophan
2 5-hydroxytryptophan

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 L-5-HTP-Related EMS Completed NCT00001918
2 Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical Trials Completed NCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

42
Heart, Skin, Lung, Testes, Brain, Bone, Eye

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 3064)
# Title Authors Year
1
Effect of Physician-Staffed Emergency Medical Services (P-EMS) on the Outcome of Patients with Severe Traumatic Brain Injury: A Review of the Literature. ( 30693835 )
2019
2
Comparison of EMS Provider In-Transit Performance and Exertion with Standard and Experimental Resuscitation Protocols during Simulated Out-of-Hospital Cardiac Arrest. ( 31042340 )
2019
3
Feasibility of Out-of-Hospital Cardiac Arrest Ultrasound by EMS Physicians. ( 30192687 )
2019
4
Performance of the RACE Score for the Prehospital Identification of Large Vessel Occlusion Stroke in a Suburban/Rural EMS Service. ( 30668202 )
2019
5
Workplace Incivility Among Nationally Certified EMS Professionals and Associations with Workforce-Reducing Factors and Organizational Culture. ( 30118629 )
2019
6
Videographic Assessment of the Quality of EMS to ED Handoff Communication During Pediatric Resuscitations. ( 30118642 )
2019
7
Death by Suicide-The EMS Profession Compared to the General Public. ( 30136908 )
2019
8
Patient perceptions of EMS provider attire. ( 30401595 )
2019
9
Sexual harassment and its relationship with depressive symptoms: A nationwide study of Korean EMS providers. ( 30507041 )
2019
10
Comparison of Outcomes and Characteristics of Emergency Medical Services (EMS)-Witnessed, Bystander-Witnessed, and Unwitnessed Out-of-Hospital Cardiac Arrests in Singapore. ( 30795712 )
2019
11
Military Considerations in Emergency Medical Services (EMS). ( 30797311 )
2019
12
Social Support Outside the Workplace, Coping Styles, and Burnout in a Cohort of EMS Providers From Minnesota. ( 31064273 )
2019
13
Tracking Senior Fall and Fall-Related Injury EMS Calls to Target Fall Prevention Programs, Salt Lake County, Utah. ( 31002637 )
2019
14
A single-base change at a splice site in Wx-A1 caused incorrect RNA splicing and gene inactivation in a wheat EMS mutant line. ( 30993362 )
2019
15
Acute coronary syndromes in insulin treated diabetics, elderly and female patients: remaining gaps in EMS activation, therapy and clinical outcomes. ( 30964339 )
2019
16
Predictors of Hypothermia upon Trauma Center Arrival in Severe Trauma Patients Transported to Hospital via EMS. ( 30945956 )
2019
17
EMS Can Safely Transport Intoxicated Patients to a Sobering Center as an Alternate Destination. ( 30926186 )
2019
18
Evidence-Based Guidelines for EMS Administration of Naloxone. ( 30924736 )
2019
19
Caring for Infectious Disease in the Prehospital Setting: A Qualitative Analysis of EMS Providers Experiences and Suggestions for Improvement. ( 30917729 )
2019
20
How Well Do EMS Providers Predict Intracranial Hemorrhage in Head-Injured Older Adults? ( 30895835 )
2019
21
Identification and Description of Non-Fatal Opioid Overdoses using Rhode Island EMS Data, 2016-2018. ( 30823701 )
2019
22
Effects of Real-time EMS direction on Optimizing EMS Turnaround and Load-balancing Between Neighboring Hospital Campuses. ( 30798628 )
2019
23
An Executive Summary of Educational Content from EMS Agenda 2050. ( 30773955 )
2019
24
Examination of EMS Decision Making in Determining Suitability of Patient Diversion to Urgent Care Centers. ( 30717383 )
2019
25
Organizational response to workplace violence, and its association with depressive symptoms: A nationwide survey of 1966 Korean EMS providers. ( 30698342 )
2019
26
The Digital EMS California Academy of Learning: One State's Innovative Approach to EMS Fellow Education. ( 30680354 )
2019
27
Existing Science on Human Factors and Ergonomics in the Design of Ambulances and EMS Equipment. ( 30638417 )
2019
28
Introduction of a New EMS Protocol Using the Communities of Practice Educational Model. ( 30630539 )
2019
29
Systematic Review of Community Paramedicine and EMS Mobile Integrated Health Care Interventions in the United States. ( 30614761 )
2019
30
Pediatric Behavioral Health-Related EMS Encounters: A Statewide Analysis. ( 30612501 )
2019
31
Gender Differences in the Quality of EMS Care Nationwide for Chest Pain and Out-of- Hospital Cardiac Arrest. ( 30545703 )
2018
32
A potential termination of resuscitation rule for EMS to implement in the field for out-of-hospital cardiac arrest: An observational cohort study. ( 29940294 )
2018
33
Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome. ( 29037509 )
2018
34
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. ( 29800716 )
2018
35
Prehospital Blood Product Administration Opportunities in Ground Transport ALS EMS - A Descriptive Study. ( 29669612 )
2018
36
Humoral and cell-mediated immune responses to influenza vaccination in equine metabolic syndrome (EMS) horses. ( 29678227 )
2018
37
AED use before EMS arrival: When survival becomes a matter of law and system in Italy, which can be improved. ( 29762703 )
2018
38
Development and implementation of a geographical area categorisation method with targeted performance indicators for nationwide EMS in Finland. ( 29764468 )
2018
39
EMS providers do not use FOAM for education. ( 29797111 )
2018
40
Antimutagenic activity of compounds isolated from Ajuga bracteosa Wall ex. Benth against EMS induced mutagenicity in mice. ( 29854582 )
2018
41
Preventing EMS workplace violence: A mixed-methods analysis of insights from assaulted medics. ( 29861309 )
2018
42
Efficacy and Safety of Low Frequency Whole-Body Electromyostimulation (WB-EMS) to Improve Health-Related Outcomes in Non-athletic Adults. A Systematic Review. ( 29875684 )
2018
43
Characterization of the loss-of-function mutant NH101 for yield under phosphate deficiency from EMS-induced mutants of rice variety Nagina22. ( 29957570 )
2018
44
Evaluation of Oxidative Stress and Mitophagy during Adipogenic Differentiation of Adipose-Derived Stem Cells Isolated from Equine Metabolic Syndrome (EMS) Horses. ( 29977307 )
2018
45
Ten years of EMS Fall Calls in a Community: An Opportunity for Injury Prevention Strategies. ( 30013811 )
2018
46
An EMS-induced new sequence variant, TEMS5032, in the coding region of SRS3 gene leads to shorter grain length in rice (Oryza sativa L.). ( 30014258 )
2018
47
Simulated EMS response times until patients located in public train stations: A geospatial model to improve on-foot accessibility. ( 30077741 )
2018
48
Burnout and safety outcomes - a cross-sectional nationwide survey of EMS-workers in Germany. ( 30126358 )
2018
49
State of the Evidence for Emergency Medical Services (EMS) Care: The Evolution and Current Methodology of the Prehospital Evidence-Based Practice (PEP) Program. ( 30129435 )
2018
50
Innovations in EMS Education. ( 30192684 )
2018

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
2
Show member pathways
12.54 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
3
Show member pathways
12.35 HLA-DQA1 HLA-DRB1 IFNG
4
Show member pathways
12.24 IFNG IL5 TGFB1
5
Show member pathways
12.23 HLA-DQA1 HLA-DRB1 IFNG
6
Show member pathways
12.09 HLA-DQA1 HLA-DRB1 IFNG IL5 TGFB1
7 12.03 HLA-DQA1 HLA-DRB1 TGFB1
8
Show member pathways
11.98 IFNG IL5 TGFB1
9
Show member pathways
11.94 HLA-DQA1 HLA-DRB1 IFNG TGFB1
10 11.88 HLA-DQA1 HLA-DRB1 IFNG TGFB1
11
Show member pathways
11.79 IFNG IL5 TGFB1
12 11.6 HLA-DQA1 HLA-DRB1 IL5
13 11.49 HLA-DQA1 HLA-DRB1
14 11.48 IFNG TGFB1
15 11.45 IFNG TGFB1
16 11.44 HLA-DQA1 HLA-DRB1
17 11.42 IL5 TGFB1
18 11.37 IFNG TGFB1
19 11.27 IFNG TGFB1
20 11.26 IFNG TGFB1
21 11.23 IFNG IL5
22 11.22 HLA-DQA1 HLA-DRB1 IFNG TGFB1
23 11.12 IDO1 IFNG
24 11.05 IFNG IL5
25 11 IFNG IL5
26 10.89 IFNG IL5
27 10.88 HLA-DRB1 IFNG TGFB1
28 10.39 HLA-DRB1 IFNG IL5 TGFB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.37 HLA-DQA1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQA1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.26 HLA-DQA1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQA1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DRB1
6 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DRB1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.76 CRH IFNG TGFB1
2 positive regulation of cell proliferation GO:0008284 9.73 CRH IFNG IL5 TGFB1
3 negative regulation of gene expression GO:0010629 9.72 CRH IFNG TGFB1
4 immune response GO:0006955 9.67 HLA-DQA1 HLA-DRB1 IFNG IL5
5 positive regulation of protein phosphorylation GO:0001934 9.65 CRH IFNG TGFB1
6 extrinsic apoptotic signaling pathway GO:0097191 9.58 IFNG TGFB1
7 antigen processing and presentation GO:0019882 9.57 HLA-DQA1 HLA-DRB1
8 cellular response to dexamethasone stimulus GO:0071549 9.56 CRH TGFB1
9 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 9.54 CRH HLA-DRB1
10 positive regulation of interleukin-12 production GO:0032735 9.52 IDO1 IFNG
11 positive regulation of protein complex assembly GO:0031334 9.51 IFNG TGFB1
12 response to immobilization stress GO:0035902 9.49 CRH TGFB1
13 regulation of regulatory T cell differentiation GO:0045589 9.46 IFNG TGFB1
14 inflammatory response GO:0006954 9.46 CRH IDO1 IL5 TGFB1
15 female pregnancy GO:0007565 9.43 CRH IDO1 TGFB1
16 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.4 HLA-DQA1 HLA-DRB1
17 negative regulation of interleukin-17 production GO:0032700 9.32 IFNG TGFB1
18 interferon-gamma-mediated signaling pathway GO:0060333 9.13 HLA-DQA1 HLA-DRB1 IFNG
19 negative regulation of T cell proliferation GO:0042130 8.8 HLA-DRB1 IDO1 TGFB1

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQA1 HLA-DRB1
2 cytokine activity GO:0005125 9.13 IFNG IL5 TGFB1
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DRB1

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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