EMS
MCID: ESN002
MIFTS: 38

Eosinophilia-Myalgia Syndrome (EMS)

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Eosinophilia-Myalgia Syndrome

MalaCards integrated aliases for Eosinophilia-Myalgia Syndrome:

Name: Eosinophilia-Myalgia Syndrome 12 74 52 54 43 15 17 71
Syndrome with Inflammatory and Autoimmune Components That Affect the Skin, Fascia, Muscle, Nerve, Blood Vessels, Lung, and Heart 52
Severe Muscle Pain and Abnormally High Eosinophils 52
Eosinophilia Myalgia Syndrome 12
L-Tryptophan Induced Ems 52
Ems 52

Classifications:



External Ids:

Disease Ontology 12 DOID:998
ICD9CM 34 710.5
MeSH 43 D016603
SNOMED-CT 67 95416007
UMLS 71 C0085179

Summaries for Eosinophilia-Myalgia Syndrome

MalaCards based summary : Eosinophilia-Myalgia Syndrome, also known as syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart, is related to hypereosinophilic syndrome and toxic oil syndrome, and has symptoms including muscle weakness, myalgia and muscle cramp. An important gene associated with Eosinophilia-Myalgia Syndrome is IL5 (Interleukin 5), and among its related pathways/superpathways are Allograft rejection and Immune response IFN alpha/beta signaling pathway. The drug 5-hydroxytryptophan has been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung.

Wikipedia : 74 Eosinophilia-myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion... more...

Related Diseases for Eosinophilia-Myalgia Syndrome

Diseases related to Eosinophilia-Myalgia Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 31.6 IL5 IFNG FIP1L1
2 toxic oil syndrome 31.2 IL5 IFNG IDO1 AHR
3 eosinophilic fasciitis 31.0 IL5 IFNG BMP6 AHR
4 myositis 30.6 IFNG HLA-DRB1 HLA-DQA1
5 keloid disorder 30.5 TGFB1 BMP6
6 interstitial lung disease 30.2 TGFB1 IL5 IFNG
7 chronic fatigue syndrome 30.2 IL5 IFNG CRH
8 connective tissue disease 30.2 IFNG HLA-DRB1 HLA-DQA1 BMP6
9 lung disease 29.8 TGFB1 IL5 IFNG BMP6
10 autoimmune disease 29.0 TGFB1 IL5 IFNG IDO1 HLA-DRB1 HLA-DQA1
11 fasciitis 10.9
12 systemic scleroderma 10.7
13 exanthem 10.7
14 myopathy 10.6
15 polyneuropathy 10.6
16 neuropathy 10.6
17 peripheral nervous system disease 10.5
18 vasculitis 10.5
19 alopecia 10.5
20 localized scleroderma 10.4
21 pulmonary hypertension 10.4
22 neuritis 10.4
23 fibromyalgia 10.4
24 atopic keratoconjunctivitis 10.4 IL5 IFNG
25 scleroderma, familial progressive 10.4
26 respiratory failure 10.4
27 skin disease 10.4
28 spotted fever rickettsiosis 10.3 IFNG IDO1
29 juvenile myasthenia gravis 10.3 TGFB1 HLA-DRB1
30 nickel allergic contact dermatitis 10.3 IL5 IFNG
31 pustulosis palmaris et plantaris 10.3 TGFB1 IL5
32 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 IL5 IFNG
33 idiopathic nephrotic syndrome 10.3 TGFB1 HLA-DRB1
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
35 myositis fibrosa 10.3
36 polymyositis 10.3
37 chronic beryllium disease 10.3 IFNG HLA-DRB1
38 pemphigoid gestationis 10.3 IL5 HLA-DRB1
39 primary adrenal insufficiency 10.3 HLA-DRB1 HLA-DQA1
40 beryllium disease 10.3 HLA-DRB1 HLA-DQA1
41 osteonecrosis of the jaw 10.3 TGFB1 HLA-DRB1
42 cow milk allergy 10.3 TGFB1 IL5
43 mucocutaneous leishmaniasis 10.3 IL5 IFNG
44 focal epithelial hyperplasia 10.2 HLA-DRB1 HLA-DQA1
45 berylliosis 10.2 IFNG HLA-DRB1
46 clonorchiasis 10.2 TGFB1 IFNG
47 cholecystolithiasis 10.2 TGFB1 BMP6
48 idiopathic neutropenia 10.2 TGFB1 HLA-DRB1
49 dupuytren contracture 10.2 TGFB1 BMP6
50 ocular cicatricial pemphigoid 10.2 TGFB1 HLA-DRB1

Graphical network of the top 20 diseases related to Eosinophilia-Myalgia Syndrome:



Diseases related to Eosinophilia-Myalgia Syndrome

Symptoms & Phenotypes for Eosinophilia-Myalgia Syndrome

UMLS symptoms related to Eosinophilia-Myalgia Syndrome:


muscle weakness, myalgia, muscle cramp, muscle rigidity, muscle spasticity

Drugs & Therapeutics for Eosinophilia-Myalgia Syndrome

Drugs for Eosinophilia-Myalgia Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 5-hydroxytryptophan

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 L-5-Hydroxy-Tryptophan-Related Eosinophilia-Myalgia Syndrome (EMS): Clinical Patient Evaluation Completed NCT00001918
2 Survey of the Use of Alternative Medical Therapies in Adult Cancer Patients Enrolled in Phase I Clinical Trials Completed NCT00001695

Search NIH Clinical Center for Eosinophilia-Myalgia Syndrome

Cochrane evidence based reviews: eosinophilia-myalgia syndrome

Genetic Tests for Eosinophilia-Myalgia Syndrome

Anatomical Context for Eosinophilia-Myalgia Syndrome

MalaCards organs/tissues related to Eosinophilia-Myalgia Syndrome:

40
Skin, Heart, Lung, Brain, Spinal Cord, Skeletal Muscle, Small Intestine

Publications for Eosinophilia-Myalgia Syndrome

Articles related to Eosinophilia-Myalgia Syndrome:

(show top 50) (show all 489)
# Title Authors PMID Year
1
1,1'-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: association of eosinophilia-myalgia syndrome with a L-tryptophan contaminant. 61 54
8132737 1994
2
Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome. 61 54
2236076 1990
3
Pharmacovigilance and drug-induced rare diseases: Strengths of the French Network of Regional Pharmacovigilance Centres. 61
32113688 2020
4
[Hypereosinophilic syndrome and other rheumatic diseases with hypereosinophilia]. 61
30937528 2019
5
Peak AAA fatty acid homolog contaminants present in the dietary supplement l-Tryptophan associated with the onset of eosinophilia-myalgia syndrome. 61
29800716 2018
6
Structure determination of disease associated peak AAA from l-Tryptophan implicated in the eosinophilia-myalgia syndrome. 61
29037509 2018
7
Possible Parkinson's Disease Induced by Chronic Manganese Supplement Ingestion. 61
28074748 2016
8
Prediction of drug-induced eosinophilia adverse effect by using SVM and naïve Bayesian approaches. 61
26044554 2016
9
[Eosinophilic fasciitis (Shulman's disease): Diagnostic and therapeutic review]. 61
26385125 2015
10
Eosinophilia in Rheumatologic/Vascular Disorders. 61
26209895 2015
11
[Eosinophilic fasciitis]. 61
25897110 2015
12
Eosinophilia-myalgia syndrome induced by excessive L-tryptophan intake from cashew nuts. 61
32288933 2014
13
Immunohistochemical studies of the kynurenine pathway in morphea. 61
24385714 2013
14
Effects and side effects associated with the non-nutritional use of tryptophan by humans. 61
23077193 2012
15
Eosinophilic fasciitis (Shulman disease). 61
23040360 2012
16
Severe eosinophilic syndrome associated with the use of probiotic supplements: a new entity? 61
23259129 2012
17
Environmental- and injury-related epidemic-assistance investigations, 1946-2005. 61
22135395 2011
18
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan. 61
21702023 2011
19
AHR activation by tryptophan--pathogenic hallmark of Th17-mediated inflammation in eosinophilic fasciitis, eosinophilia-myalgia-syndrome and toxic oil syndrome? 61
19941898 2010
20
[Skin manifestations of toxic syndrome due to denatured rapeseed oil]. 61
20038361 2009
21
[Eosinophilia myalgia syndrome (EMS) caused by L-tryptophan product and toxic oil syndrome (TOS) caused by denatured rape-seed oil]. 61
20065617 2009
22
Immunogenetic risk and protective factors for the development of L-tryptophan-associated eosinophilia-myalgia syndrome and associated symptoms. 61
19790128 2009
23
[Shulman's syndrome (eosinophilic fasciitis)]. 61
19300913 2009
24
Neuromuscular disorders associated with apical hypertrophic cardiomyopathy. 61
19317303 2009
25
Activity of certain drugs in inducing of inflammatory myopathies with cutaneous manifestations. 61
18613806 2008
26
[Current differential diagnosis of hypereosinophilic syndrome]. 61
18666600 2007
27
[Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake]. 61
18200378 2007
28
Generation of quinoneimine intermediates in the bioactivation of 3-(N-phenylamino)alanine (PAA) by human liver microsomes: a potential link between eosinophilia-myalgia syndrome and toxic oil syndrome. 61
17892268 2007
29
Part II. Eosinophilia-Myalgia Syndrome: further correlations between compromised histamine degradation, eosinophilias and myopathies. 61
17806156 2007
30
[Diagnostic problems in eosinophilic fasciitis]. 61
17424924 2006
31
Is the L-tryptophan metabolite quinolinic acid responsible for eosinophilic fasciitis? 61
16820992 2006
32
Calcinosis cutis in a patient with eosinophilia-myalgia syndrome: case report. 61
16838769 2006
33
Drug-, toxin-, and radiation therapy-induced eosinophilic pneumonia. 61
16612770 2006
34
Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. 61
16023217 2006
35
[Application of multi-slice spiral CT in the diagnosis of pulmonary hypertension]. 61
16548187 2006
36
Does 5-hydroxytryptophan cause acute and chronic toxic perturbations in rats? 61
20021026 2006
37
A heretofore undisclosed crux of eosinophilia-myalgia syndrome: compromised histamine degradation. 61
16307217 2005
38
Miliary tuberculosis in a patient with eosinophilic fasciitis. 61
15678644 2005
39
Review article toxic oil syndrome: review of immune aspects of the disease. 61
18958659 2005
40
Safety of 5-hydroxy-L-tryptophan. 61
15068828 2004
41
[Diagnostic performance of echocardiography in the follow-up of patients with toxic oil syndrome]. 61
14670272 2003
42
Non-L-tryptophan related eosinophilia-myalgia syndrome with hypoproteinemia and hypoalbuminemia. 61
12610828 2003
43
Structural characterization of a case-implicated contaminant, "Peak X," in commercial preparations of 5-hydroxytryptophan. 61
12508395 2003
44
Scleroderma-like cutaneous syndromes. 61
11890876 2002
45
Tryptophan and 5-hydroxytryptophan for depression. 61
11869656 2002
46
L-tryptophan contaminant 'peak E' induces the release of IL-5 and IL-10 by peripheral blood mononuclear cells from patients with functional somatic syndromes. 61
11703359 2001
47
Rigorous new approach to constructing a gold standard for validating new diagnostic criteria, as exemplified by the eosinophilia-myalgia syndrome. 61
11606145 2001
48
The toxic oil syndrome: 20 years on. 61
11501225 2001
49
Effect of L-tryptophan supplementation on eosinophils and eotaxin in guinea pigs. 61
11361035 2001
50
[Eosinophilia myalgia syndrome, toxic oil syndrome]. 61
11555954 2001

Variations for Eosinophilia-Myalgia Syndrome

Expression for Eosinophilia-Myalgia Syndrome

Search GEO for disease gene expression data for Eosinophilia-Myalgia Syndrome.

Pathways for Eosinophilia-Myalgia Syndrome

Pathways related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.6 TGFB1 IL5 IFNG HLA-DRB1 HLA-DQA1
2
Show member pathways
12.05 TGFB1 IL5 IFNG BMP6
3
Show member pathways
12.01 TGFB1 IFNG HLA-DRB1 HLA-DQA1
4
Show member pathways
11.97 TGFB1 IL5 IFNG HLA-DRB1 HLA-DQA1 AHR
5 11.92 TGFB1 IFNG HLA-DRB1 HLA-DQA1
6 11.68 IL5 HLA-DRB1 HLA-DQA1
7 11.64 TGFB1 IFNG BMP6
8 11.56 IL5 IFNG AHR
9 11.43 TGFB1 IFNG HLA-DRB1 HLA-DQA1
10 11.26 TGFB1 IFNG AHR
11 11 IL5 IFNG AHR
12 10.96 IL5 IFNG
13 10.88 TGFB1 IFNG HLA-DRB1
14 10.6 TGFB1 IL5
15 10.39 TGFB1 IL5 IFNG HLA-DRB1

GO Terms for Eosinophilia-Myalgia Syndrome

Cellular components related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DRB1 HLA-DQA1
2 MHC class II protein complex GO:0042613 8.62 HLA-DRB1 HLA-DQA1

Biological processes related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.87 TGFB1 IFNG CRH BMP6
2 positive regulation of cell proliferation GO:0008284 9.77 TGFB1 IL5 IFNG CRH BMP6
3 immune response GO:0006955 9.72 IL5 IFNG HLA-DRB1 HLA-DQA1 BMP6
4 female pregnancy GO:0007565 9.63 TGFB1 IDO1 CRH
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 TGFB1 IL5 BMP6
6 interferon-gamma-mediated signaling pathway GO:0060333 9.58 IFNG HLA-DRB1 HLA-DQA1
7 positive regulation of interleukin-12 production GO:0032735 9.56 IFNG IDO1
8 positive regulation of protein phosphorylation GO:0001934 9.56 TGFB1 IFNG HLA-DRB1 CRH
9 macrophage differentiation GO:0030225 9.55 IFNG HLA-DRB1
10 regulation of regulatory T cell differentiation GO:0045589 9.54 TGFB1 IFNG
11 positive regulation of SMAD protein signal transduction GO:0060391 9.52 TGFB1 BMP6
12 negative regulation of interleukin-17 production GO:0032700 9.51 TGFB1 IFNG
13 positive regulation of vascular permeability GO:0043117 9.49 TGFB1 BMP6
14 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.48 HLA-DRB1 HLA-DQA1
15 inflammatory response GO:0006954 9.35 TGFB1 IL5 IDO1 CRH BMP6
16 negative regulation of T cell proliferation GO:0042130 9.33 TGFB1 IDO1 HLA-DRB1
17 response to immobilization stress GO:0035902 8.8 TGFB1 HNMT CRH

Molecular functions related to Eosinophilia-Myalgia Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 TGFB1 IL5 BMP6
2 MHC class II receptor activity GO:0032395 8.96 HLA-DRB1 HLA-DQA1
3 cytokine activity GO:0005125 8.92 TGFB1 IL5 IFNG BMP6

Sources for Eosinophilia-Myalgia Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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