Eosinophilic Gastroenteritis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ESN005 MIFTS: 53	Eosinophilic Gastroenteritis Categories: Gastrointestinal diseases, Rare diseases
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Aliases & Classifications for Eosinophilic Gastroenteritis

MalaCards integrated aliases for Eosinophilic Gastroenteritis:

Name: Eosinophilic Gastroenteritis ¹² ⁷⁷ ⁶⁰ ⁵⁶ ¹⁵ ⁷⁴

Eosinophilic Gastroenterocolitis ⁶⁰

Gastroenteritis, Eosinophilic ⁷⁷

Eosinophilic Enteropathy ⁷⁴

Eosinophilic Enteritis ⁶⁰

Ege ⁶⁰

Characteristics:

Orphanet epidemiological data:

⁶⁰

eosinophilic gastroenteritis
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

ICD10: ³⁵

Diseases of the digestive system

Noninfective enteritis and colitis

Other noninfective gastroenteritis and colitis

Other specified noninfective gastroenteritis and colitis

Orphanet: ⁶⁰

Rare gastroenterological diseases

External Ids:

Disease Ontology ¹² DOID:4031

ICD9CM ³⁶ 558.41

MeSH ⁴⁵ C535952

NCIt ⁵¹ C35330

SNOMED-CT ⁶⁹ 32183007 68270003

MESH via Orphanet ⁴⁶ C535952

ICD10 via Orphanet ³⁵ K52.8

UMLS via Orphanet ⁷⁵ C1262481 C2062326

Orphanet ⁶⁰ ORPHA2070

UMLS ⁷⁴ C1262481 C2062326

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Summaries for Eosinophilic Gastroenteritis

MalaCards based summary : Eosinophilic Gastroenteritis, also known as eosinophilic gastroenterocolitis, is related to gastroenteritis and hypereosinophilic syndrome, idiopathic. An important gene associated with Eosinophilic Gastroenteritis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and Allograft rejection. The drugs Fluticasone and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and bone, and related phenotypes are eosinophilia and dysphagia

Wikipedia : ⁷⁷ Eosinophilic gastroenteritis (EG) is a rare and heterogeneous condition characterized by patchy or... more...

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Related Diseases for Eosinophilic Gastroenteritis

Diseases related to Eosinophilic Gastroenteritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)

#	Related Disease	Score	Top Affiliating Genes
1	gastroenteritis	30.7	ALB CCL11 IL5 RNASE3 TSLP
2	hypereosinophilic syndrome, idiopathic	30.3	IL3 IL5
3	milk allergy	30.2	IL5 RNASE3
4	esophagitis, eosinophilic, 1	30.2	CCL11 IL5 TSLP
5	esophagitis	30.2	CCL11 IL5 TSLP
6	churg-strauss syndrome	30.0	IL5 RNASE3
7	dermatitis	30.0	CCL11 IL5 TSLP
8	allergic bronchopulmonary aspergillosis	29.7	EPX IL5
9	eosinophilic granuloma	29.7	EPX RNASE3
10	chronic eosinophilic pneumonia	29.5	CCL11 IL5 RNASE3
11	food allergy	29.5	ALB EPX IL5 RNASE3
12	hypereosinophilic syndrome	29.4	CCL11 EPX IL3 IL5 RNASE3
13	eosinophilic pneumonia	29.4	CCL11 IL3 IL5 RNASE3
14	bronchitis	29.2	ALB CCL11 IL5 RNASE3
15	asthma	28.7	CCL11 EPX IL3 IL5 RNASE3 TSLP
16	allergic asthma	28.5	CCL11 EPX IL5 RNASE3 TSLP
17	allergic hypersensitivity disease	28.1	CCL11 EPX IL3 IL5 RNASE3 TSLP
18	eosinophilic enteropathy	12.0
19	megalencephaly-capillary malformation-polymicrogyria syndrome	11.1
20	aplastic anemia	11.1
21	pyridoxine deficiency anemia	11.1
22	exercise-induced anaphylaxis	11.1
23	paroxysmal cold hemoglobinuria	11.1
24	protein-losing enteropathy	10.3
25	pancreatitis	10.3
26	colitis	10.2
27	pyloric stenosis	10.2
28	seborrheic infantile dermatitis	10.2	IL3 IL5
29	pemphigoid gestationis	10.2	CCL11 IL5
30	duodenal ulcer	10.2
31	acute pancreatitis	10.2
32	chronic meningitis	10.2	CCL11 IL5
33	angiostrongyliasis	10.2	CCL11 IL5
34	strongyloidiasis	10.2	CCL11 IL5
35	loeffler endocarditis	10.2	IL5 RNASE3
36	eosinophilic meningitis	10.2	CCL11 IL5
37	paragonimiasis	10.2	IL5 RNASE3
38	cough variant asthma	10.2	IL5 RNASE3
39	duodenal obstruction	10.2
40	cow milk allergy	10.2	IL5 RNASE3
41	folliculitis	10.2	CCL11 IL5
42	drug allergy	10.1	ALB IL5
43	radiculopathy	10.1	CCL11 IL5
44	latex allergy	10.1	IL5 RNASE3
45	status asthmaticus	10.1	IL5 RNASE3
46	blepharoconjunctivitis	10.1	CCL11 RNASE3
47	sinusitis	10.1	IL5 RNASE3
48	giant papillary conjunctivitis	10.1	CCL11 RNASE3
49	chloramine t respiratory allergy	10.1	ALB RNASE3
50	crohn's disease	10.1

Graphical network of the top 20 diseases related to Eosinophilic Gastroenteritis:

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Symptoms & Phenotypes for Eosinophilic Gastroenteritis

Human phenotypes related to Eosinophilic Gastroenteritis:

⁶⁰ ³³ (show all 22)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	eosinophilia ⁶⁰ ³³	hallmark (90%)	Very frequent (99-80%)	HP:0001880
2	dysphagia ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0002015
3	vomiting ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0002013
4	anemia ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0001903
5	abdominal pain ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0002027
6	elevated c-reactive protein level ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0011227
7	hypoalbuminemia ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0003073
8	steatorrhea ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0002570
9	allergic rhinitis ⁶⁰ ³³	frequent (33%)	Frequent (79-30%)	HP:0003193
10	ascites ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001541
11	edema ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0000969
12	weight loss ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001824
13	asthma ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002099
14	hematochezia ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002573
15	elevated erythrocyte sedimentation rate ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0003565
16	protein-losing enteropathy ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0002243
17	atopic dermatitis ⁶⁰ ³³	occasional (7.5%)	Occasional (29-5%)	HP:0001047
18	malabsorption ⁶⁰		Frequent (79-30%)
19	leukocytosis ⁶⁰		Frequent (79-30%)
20	diarrhea ⁶⁰		Frequent (79-30%)
21	abnormality of the gastrointestinal tract ⁶⁰		Frequent (79-30%)
22	abnormal test result ⁶⁰		Frequent (79-30%)

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Drugs & Therapeutics for Eosinophilic Gastroenteritis

Drugs for Eosinophilic Gastroenteritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 128)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fluticasone

Approved, Experimental

Phase 4,Phase 3,Phase 2,Not Applicable

90566-53-3

62924

Budesonide

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

51333-22-3

5281004 63006

Lansoprazole

Approved, Investigational

Phase 4,Phase 2,Phase 1,Not Applicable

103577-45-3

3883

Dexlansoprazole

Approved, Investigational

Phase 4,Phase 2,Phase 1,Not Applicable

138530-94-6, 103577-45-3

9578005

Omeprazole

Approved, Investigational, Vet_approved

Phase 4

73590-58-6

4594

Anti-Asthmatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Respiratory System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Allergic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hormones

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Bronchodilator Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Dermatologic Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Cromolyn Sodium

Phase 4

glucocorticoids

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2,Not Applicable

Soy Bean

Phase 4,Phase 2,Phase 3,Not Applicable

Olive

Phase 4

Antacids

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

Anti-Ulcer Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

Gastrointestinal Agents

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

Proton Pump Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

Montelukast

Approved

Phase 3,Phase 1,Not Applicable

158966-92-8

5281040

Reslizumab

Approved, Investigational

Phase 3,Phase 2

Esomeprazole

Approved, Investigational

Phase 2, Phase 3,Not Applicable

161796-78-7, 161973-10-0, 119141-88-7

9568614 4594

Histamine

Approved, Investigational

Phase 3

51-45-6

774

Ketotifen

Approved

Phase 3

34580-14-8, 34580-13-7

3827

Leukotriene Antagonists

Phase 3,Phase 1,Not Applicable

Antibodies

Phase 3,Phase 2,Phase 1

Immunologic Factors

Phase 3,Phase 2,Phase 1,Not Applicable

Antibodies, Monoclonal

Phase 3,Phase 2,Phase 1

Immunoglobulins

Phase 3,Phase 2,Phase 1

Neurotransmitter Agents

Phase 3,Phase 2,Not Applicable

Antipruritics

Phase 3,Not Applicable

Histamine Antagonists

Phase 3

Histamine Phosphate

Phase 3

51-74-1

65513

Histamine H1 Antagonists

Phase 3

Omalizumab

Approved, Investigational

Phase 2,Phase 1

242138-07-4

Infliximab

Approved

Phase 2

170277-31-3

Benzocaine

Approved, Investigational

Phase 2,Not Applicable

1994-09-7, 94-09-7

2337

tannic acid

Approved

Phase 2,Not Applicable

1401-55-4

Benralizumab

Approved, Investigational

Phase 1, Phase 2

1044511-01-4

Losartan

Approved

Phase 2

114798-26-4

3961

Angiotensin II

Approved, Investigational

Phase 2

11128-99-7, 68521-88-0, 4474-91-3

172198

Bethanechol

Approved

Phase 2

674-38-4

2370

mometasone furoate

Approved, Investigational, Vet_approved

Phase 2

83919-23-7

Caseins

Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 140)

#	Name	Status	NCT ID	Phase	Drugs
1	Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis	Completed	NCT02371941	Phase 4	oral cromolyn sodium;Placebo
2	Budesonide Versus Fluticasone for Treatment of Eosinophilic Esophagitis	Completed	NCT02019758	Phase 4	Oral Viscous Budesonide;Fluticasone MDI;Placebo slurry;Placebo inhaler
3	Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis	Completed	NCT01846962	Phase 4	Budesonide;Fluticasone;Oral Viscous Budesonide (OVB)
4	EoE RCT Fluticasone and Omeprazole vs Fluticasone Alone	Recruiting	NCT03781596	Phase 4	Fluticasone;Omeprazole;Placebo oral capsule
5	The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors	Terminated	NCT01404832	Phase 4	Treat with lansoprazole 30 mg BID for 2 weeks, endoscopic examination with esophageal biopsy for patients with persistent symptoms
6	Eosinophilic Esophagitis Treatment: Montelukast vs Fluticasone	Unknown status	NCT01702701	Phase 3	Montelukast;Fluticasone
7	Open-Label Extension Study of Reslizumab in Pediatric Subjects With Eosinophilic Esophagitis	Completed	NCT00635089	Phase 3	reslizumab
8	Budesonide Orodispersible Tablet vs. Placebo in Active Eosinophilic Esophagitis	Completed	NCT02434029	Phase 3	Budesonide 1mg orodispersible tablet twice daily;Placebo orodispersible tablet twice daily
9	A Study in Adolescents and Adults With Eosinophilic Esophagitis (EoE) Measuring Histologic Response and Determine if Reduction in Dysphagia is Achieved	Completed	NCT02605837	Phase 3	Oral Budesonide Suspension (OBS);Placebo
10	Efficacy and Safety Study of Reslizumab to Treat Eosinophilic Esophagitis in Subjects Aged 5 to 18 Years	Completed	NCT00538434	Phase 2, Phase 3
11	Eosinophilic Esophagitis Intervention Trial-1 Food vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids	Completed	NCT02610816	Phase 2, Phase 3	Fluticasone Propionate, 800 mcg twice daily (post 4FED failure)
12	A Study Comparing Swallowed Flovent and Placebo in Patients With Eosinophilic Disorders	Completed	NCT00266578	Phase 3	Fluticasone Propionate
13	The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis	Completed	NCT00728481	Phase 2, Phase 3	Esomeprazole;Budesonide
14	Continuation Study With Budesonide Oral Suspension (BOS) for Adolescent and Adult Subjects With Eosinophilic Esophagitis (EoE)	Recruiting	NCT03245840	Phase 3	Budesonide oral suspension
15	Study to Determine the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients With Eosinophilic Esophagitis (EoE)	Recruiting	NCT03633617	Phase 3	Dupilumab;Placebo
16	SOFEED: Six Food vs. One Food Eosinophilic Esophagitis Diet Study	Recruiting	NCT02778867	Phase 2, Phase 3	Flovent
17	Ketotifen for Children With Functional Dyspepsia in Association With Duodenal Eosinophilia	Recruiting	NCT02484248	Phase 3	Ketotifen;Placebo
18	Maintenance of Remission With Budesonide Orodispersible Tablets vs. Placebo in Eosinophilic Esophagitis	Active, not recruiting	NCT02493335	Phase 3	Budesonide 0.5mg orodispersible tablet twice daily;Budesonide 1mg orodispersible tablet twice daily;Placebo orodispersible tablet twice daily
19	An Extension Study to Evaluate Maintenance of Efficacy and Long-term Treatment Effect of Oral Budesonide Suspension (OBS) in Adults and Adolescents With Eosinophilic Esophagitis (EoE)	Active, not recruiting	NCT02736409	Phase 3	Oral Budesonide Suspension (OBS);Placebo
20	Dose-Ranging Study of Oral Viscous Budesonide in Pediatrics With Eosinophilic Esophagitis	Completed	NCT00762073	Phase 2	budesonide;placebo
21	A Study of Flovent in Patients With Eosinophilic Esophagitis	Completed	NCT00426283	Phase 2	Flovent
22	Budesonide for Eosinophilic Esophagitis	Completed	NCT00271349	Phase 2	Budesonide
23	Milk Patch for Eosinophilic Esophagitis	Completed	NCT02579876	Phase 2	Viaskin Milk 500 mcg;Viaskin Placebo
24	Topical Steroid Treatment for Eosinophilic Esophagitis	Completed	NCT00275561	Phase 2	Fluticasone;Placebo
25	Budesonide Effervescent Tablets vs. Viscous Budesonide Suspension vs. Placebo in Eosinophilic Esophagitis	Completed	NCT02280616	Phase 2	low dose budesonide tablet;high dose budesonide tablet;high dose budesonide suspension;Placebo
26	Dose Ranging Study of RPC4046 in Eosinophilic Esophagitis	Completed	NCT02098473	Phase 2	RPC4046;Placebo
27	Omalizumab to Treat Eosinophilic Gastroenteritis	Completed	NCT00084097	Phase 2	Omalizumab
28	Proof of Concept Study of OC000459 in Eosinophilic Esophagitis	Completed	NCT01056783	Phase 2	OC000459;Placebo
29	Use of Topical Budesonide in the Treatment of Eosinophilic Esophagitis	Completed	NCT00638456	Phase 2	Budesonide plus Prevacid;placebo plus Prevacid
30	Safety and Tolerability Study of Oral EUR-1100 to Treat Eosinophilic Esophagitis	Completed	NCT01386112	Phase 1, Phase 2	EUR-1100;placebo
31	Efficacy and Safety of QAX576 in Patients With Eosinophilic Esophagitis	Completed	NCT01022970	Phase 2	QAX576 placebo;QAX576
32	Study of Dupilumab in Adult Patients With Active Eosinophilic Esophagitis (EoE)	Completed	NCT02379052	Phase 2	Dupilumab;Placebo
33	A Pilot Study of the Treatment of Eosinophilic Esophagitis With Omalizumab	Completed	NCT00123630	Phase 2	omalizumab;Placebo
34	Comparison of Esomeprazole to Aerosolized, Swallowed Fluticasone for Eosinophilic Esophagitis	Completed	NCT00123656	Phase 2	esomeprazole;fluticasone
35	OBS in Adolescent and Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension	Completed	NCT01642212	Phase 2	Oral Budesonide Suspension (MB-9);Placebo
36	Off Label Use of Infliximab in Adult Patients With Severe Eosinophilic Esophagitis	Completed	NCT00523354	Phase 2	Infliximab
37	Intravenous Mepolizumab In Children With Eosinophilic Esophagitis	Completed	NCT00358449	Phase 2	mepolizumab
38	An Evaluation Of Mepolizumab In Therapy Of Eosinophilic Oesophagitis In Adult Patients	Completed	NCT00274703	Phase 2	mepolizumab
39	Anti-Interleukin-5 Antibody to Treat Hypereosinophilic Syndrome	Completed	NCT00017862	Phase 2	SCH55700
40	Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome	Completed	NCT00266565	Phase 1, Phase 2	Mepolizumab
41	A Study of AK002 in Patients With Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis	Recruiting	NCT03496571	Phase 2	AK002
42	Benralizumab for Eosinophilic Gastritis	Recruiting	NCT03473977	Phase 1, Phase 2
43	Mepo for EoE Study	Recruiting	NCT03656380	Phase 2	Mepolizumab 300 mg;Mepolizumab 100 mg
44	Eosinophilic Esophagitis Clinical Therapy Comparison Trial	Active, not recruiting	NCT01821898	Phase 2	Oral Budesonide
45	Efficacy, Safety, and Pharmacokinetics of APT-1011 in Subjects With Eosinophilic Esophagitis (EoE)	Active, not recruiting	NCT03191864	Phase 2	APT-1011;Placebo
46	An Open-Label Trial of Losartan Potassium in Participants With Eosinophilic Esophagitis (EoE)	Active, not recruiting	NCT03029091	Phase 2	Losartan Potassium
47	Testing Effectiveness of Losartan in Patients With EoE With or Without a CTD	Active, not recruiting	NCT01808196	Phase 2	Losartan Potassium
48	An Extension Study of AK002 in Patients With Eosinophilic Gastritis and/or Eosinophilic Gastroenteritis	Enrolling by invitation	NCT03664960	Phase 2	AK002
49	DEGS - Dupilumab for Eosinophilic Gastritis Study	Not yet recruiting	NCT03678545	Phase 2	Dupilumab (blinded);Placebo (blinded);Dupilumab (open-label)
50	Efficacy and Safety of Three Doses of Florence Oral Suspension in Adults With Eosinophilic Esophagitis	Not yet recruiting	NCT02873468	Phase 2	Florence 30 μg/mL;Florence 60 μg/mL;Florence 90 μg/mL

Search NIH Clinical Center for Eosinophilic Gastroenteritis

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Genetic Tests for Eosinophilic Gastroenteritis

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Anatomical Context for Eosinophilic Gastroenteritis

MalaCards organs/tissues related to Eosinophilic Gastroenteritis:

⁴²

Colon, Testes, Bone, Small Intestine, Skin, Liver, T Cells

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Publications for Eosinophilic Gastroenteritis

Articles related to Eosinophilic Gastroenteritis:

(show top 50) (show all 439)

#	Title	Authors	Year
1	Eosinophilic Gastroenteritis Presenting With Gastric Perforation. ( 29366927 )	Matsueda K...Toyokawa T	2019
2	Eosinophilic gastroenteritis: An unusual presentation of a rare disease. ( 29555104 )	Sylva D...P?rez JC	2019
3	Clinical and pathological profile of eosinophilic gastroenteritis. ( 30113369 )	Sato H...Terai S	2019
4	Abdominal ascites in children as the presentation of eosinophilic gastroenteritis: A surgeon's perspective. ( 30528318 )	Cheng LJ...Zhang SC	2019
5	A Case of Eosinophilic Gastroenteritis Associated with Eosinophilic Ascites Diagnosed by Full-Thickness Biopsy of the Small Intestine. ( 30755542 )	Salah HT...Alanazi KM	2019
6	Abnormal thymic stromal lymphopoietin expression in the gastrointestinal mucosa of patients with eosinophilic gastroenteritis. ( 30763528 )	Guo H...Jin Y	2019
7	Modified oral enteric-coated budesonide regimens to treat pediatric eosinophilic gastroenteritis, a single center experience. ( 30763733 )	Kennedy K...Ruffner MA	2019
8	Clinical features and treatment outcomes of eosinophilic gastroenteritis : an analysis of 28 cases. ( 30888747 )	Yang XM...Zhang Y	2019
9	Eosinophilic Gastroenteritis: Clinical Manifestation, Natural Course, and Evaluation of Treatment with Corticosteroids and Vedolizumab. ( 30982212 )	Grandinetti T...Hruz P	2019
10	Endoscopic Features and Diagnostic Procedures of Eosinophilic Gastroenteritis. ( 30996166 )	Ashitani K...Imaeda H	2019
11	Efficacy of an elimination diet in a patient with eosinophilic gastroenteritis : a pediatric case with multiple food allergies. ( 31064942 )	Sasaki A...Kagami S	2019
12	Severe asthma with eosinophilic gastroenteritis effectively managed by mepolizumab and omalizumab. ( 30056148 )	Han D...Lee JK	2018
13	Eosinophilic gastroenteritis complicating acute calculus eosinophilic cholecystitis 6 months after cholecystectomy. ( 30370999 )	Hui CK	2018
14	Eosinophilic Gastroenteritis and Colitis: Not Yet Ready for the Big Leagues. ( 29620603 )	Zevit N...Furuta GT	2018
15	Post-partum eosinophilic gastroenteritis: A case report. ( 28081983 )	Ribeiro MI...Barata C	2018
16	A Prospective Study on the Prevalence, Extent of Disease and Outcome of Eosinophilic Gastroenteritis in Patients Presenting with Lower Abdominal Symptoms. ( 29212311 )	Hui CK...Hui NK	2018
17	Eosinophilic Gastroenteritis in Which Obstructive Jaundice Developed due to Invagination of the Duodenal Wall. ( 29434146 )	Hamamoto H...Ido A	2018
18	Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus. ( 29533199 )	Walker MM...Talley NJ	2018
19	Vedolizumab Treatment May Reduce Steroid Burden and Improve Histology in Patients With Eosinophilic Gastroenteritis. ( 29596982 )	Kim HP...Dellon ES	2018
20	Successful Food-Elimination Diet in an Adult with Eosinophilic Gastroenteritis. ( 29850645 )	Okimoto E...Kinoshita Y	2018
21	Ascites in a Young Woman: A Rare Presentation of Eosinophilic Gastroenteritis. ( 29862093 )	Santos C...Cardoso P	2018
22	Takayasu's arteritis associated with eosinophilic gastroenteritis, possibly via the overactivation of Th17. ( 29942355 )	Fujiya M...Makino Y	2018
23	Massive hemorrhagic ascites: A rare presentation of eosinophilic gastroenteritis. ( 30079343 )	Shi L...Jiang ZY	2018
24	Prevalence of Eosinophilic Gastroenteritis and Colitis in a Population-Based Study, From 2012 to 2017. ( 28603057 )	Mansoor E...Cooper GS	2017
25	Eosinophilic gastroenteritis: A state-of-the-art review. ( 27253425 )	Zhang M...Li Y	2017
26	Eosinophilic gastroenteritis in a teenager: A rare diagnosis. ( 27283450 )	Masiques Mas L...Cuatrecases M	2017
27	Eosinophilic gastroenteritis: three clinical cases with different presentations. ( 28063615 )	Campos Ruiz A...Orive-Calzada A	2017
28	Eosinophilic Gastroenteritis Presenting with Red Streaking. ( 28250308 )	Goto A...Sakaida I	2017
29	Eosinophilic gastroenteritis caused by eating hens' eggs: A case report. ( 28279648 )	Yanagimoto Y...Kaneko K	2017
30	Hematemesis as Initial Presentation in a 10-Week-Old Infant with Eosinophilic Gastroenteritis. ( 28299223 )	Shetty V...Kesavan A	2017
31	CCR3 Monoclonal Antibody Inhibits Eosinophilic Inflammation and Mucosal Injury in a Mouse Model of Eosinophilic Gastroenteritis. ( 28497923 )	Song DJ...Choung JT	2017
32	Diagnosis of eosinophilic gastroenteritis is easily missed. ( 28596692 )	Abassa KK...Guo YW	2017
33	Lack of Knowledge and Low Readiness for Health Care Transition in Eosinophilic Esophagitis and Eosinophilic Gastroenteritis. ( 28644350 )	Eluri S...Dellon ES	2017
34	Eosinophilic gastroenteritis presenting as upper gastrointestinal hematoma and ulcers after endoscopic biopsy: A case report and literature review. ( 28906408 )	Chen B...Liu C	2017
35	Serum Biomarkers for the Diagnosis of Eosinophilic Esophagitis and Eosinophilic Gastroenteritis. ( 28943560 )	Ishihara S...Kinoshita Y	2017
36	Eosinophilic Ascites: Uncommon Presentation of Eosinophilic Gastroenteritis in a Young Adult Male. ( 29255753 )	Louren?o LC...Reis J	2017
37	Eosinophilic Ascites-Rarest Presentation of a Rare Disease, Eosinophilic Gastroenteritis. ( 29313586 )	Bagasarawala I...Runderawala H	2017
38	Eosinophilic gastroenteritis; a report of two cases with different presentations. ( 29511487 )	Sadeghi A...Lahmi F	2017
39	Subserous Eosinophilic Gastroenteritis: A Rare Cause of Ascites. ( 30755942 )	Ferreira AA...Silva A	2017
40	Severe Eosinophilic Gastroenteritis in a Crohn's Disease Patient Treated With Infliximab and Adalimumab. ( 27018120 )	Muir A...Piccoli DA	2016
41	A Case of Eosinophilic Gastroenteritis Forming a Rigid Chamber Mimicking Giant Duodenal Ulcer on Computed Tomography Imaging. ( 27086704 )	Shimamoto Y...Harima Y	2016
42	Eosinophilic Esophagitis, Eosinophilic Gastroenteritis, and Eosinophilic Colitis: Common Mechanisms and Differences between East and West. ( 29922659 )	Ishihara S...Schoepfer A	2016
43	Eosinophilic Gastroenteritis and Colitis: a Comprehensive Review. ( 26054822 )	Uppal V...Kutsch E	2016
44	Severe eosinophilic gastroenteritis. ( 26802190 )	Zuo L...Yang Z	2016
45	Eosinophilic gastroenteritis in a patient with Bruton's tyrosine kinase deficiency. ( 26840762 )	Yamazaki S...Shimizu T	2016
46	Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL-33 levels. ( 26948075 )	Shoda T...Nomura I	2016
47	Eosinophilic Gastroenteritis: An Underdiagnosed Condition. ( 27234270 )	Alhmoud T...Parasher G	2016
48	Eosinophilic Gastroenteritis as a Rare Cause of Recurrent Epigastric Pain. ( 27274524 )	Safari MT...Ehsani Ardakani MJ	2016
49	Eosinophilic Gastroenteritis : Brief Review. ( 27382945 )	Shih HM...Lin IT	2016
50	Eosinophilic gastroenteritis in a woman with multiple sclerosis on dimethyl fumarate. ( 27466473 )	Purchiaroni F...Annibale B	2016

Sources

Genes for Eosinophilic Gastroenteritis

Genes related to Eosinophilic Gastroenteritis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	31.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	15833687
2	IL5	Interleukin 5	Protein Coding	30.58	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁶ GeneCards inferred via : Publications (show sections)	7814459 1380204 10359103 (more) 15187490 8608886
3	RNASE3	Ribonuclease A Family Member 3	Protein Coding	22.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TSLP	Thymic Stromal Lymphopoietin	Protein Coding	22.03	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL3	Interleukin 3	Protein Coding	21.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	EPX	Eosinophil Peroxidase	Protein Coding	20.81	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	ALB	Albumin	Protein Coding	20.74	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Eosinophilic Gastroenteritis

Sources

Expression for Eosinophilic Gastroenteritis

Search GEO for disease gene expression data for Eosinophilic Gastroenteritis.

Sources

Pathways for Eosinophilic Gastroenteritis

Pathways related to Eosinophilic Gastroenteritis according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	JAK-STAT signaling pathway (KEGG) ⁶⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁷ JAK-STAT signaling pathway ³⁸	11.86	IL3 IL5 TSLP
2	Allograft rejection ³⁸ ¹ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	11.76	CCL11 EPX IL3 IL5 RNASE3
3	Immune response IFN gamma signaling pathway ²³ Show member pathways IFN-gamma pathway ¹	11.65	CCL11 IL3 IL5
4	Hematopoietic cell lineage ³⁸	11.52	IL3 IL5
5	Innate Lymphoid Cell Differentiation Pathways ⁶⁶	11.43	IL5 TSLP
6	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.39	IL3 IL5
7	IL4-mediated signaling events ¹	11.29	CCL11 IL5
8	Lung fibrosis ¹	11.28	CCL11 IL5
9	Hematopoietic Stem Cell Differentiation ¹	11.11	IL3 IL5
10	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.08	CCL11 TSLP
11	Th2 Differentiation Pathway ⁶⁶	11.03	CCL11 IL5
12	Development and heterogeneity of the ILC family ¹	10.76	IL5 TSLP
13	Cytokines and Inflammatory Response ¹	10.62	IL3 IL5
14	G-protein signaling_RhoB regulation pathway ²³	10.36	CCL11 IL3 IL5

Sources

GO Terms for Eosinophilic Gastroenteritis

Cellular components related to Eosinophilic Gastroenteritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.5	ALB CCL11 EPX IL3 IL5 RNASE3
2	extracellular space	GO:0005615	9.17	ALB CCL11 EPX IL3 IL5 RNASE3

Biological processes related to Eosinophilic Gastroenteritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.54	CCL11 IL3 IL5
2	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.32	IL3 IL5
3	cellular oxidant detoxification	GO:0098869	9.26	ALB EPX
4	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.16	IL3 TSLP
5	cytokine-mediated signaling pathway	GO:0019221	9.13	CCL11 IL3 IL5
6	regulation of signaling receptor activity	GO:0010469	8.92	CCL11 IL3 IL5 TSLP

Molecular functions related to Eosinophilic Gastroenteritis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	8.92	CCL11 IL3 IL5 TSLP

Sources

Sources for Eosinophilic Gastroenteritis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia