MCID: ESN017
MIFTS: 39

Eosinophilic Granuloma

Categories: Blood diseases, Bone diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Eosinophilic Granuloma

Summaries for Eosinophilic Granuloma

MalaCards based summary : Eosinophilic Granuloma, also known as chronic and localized langerhans cell histiocytosis, is related to histiocytosis and langerhans cell histiocytosis. An important gene associated with Eosinophilic Granuloma is CD1A (CD1a Molecule), and among its related pathways/superpathways are Innate Immune System and Hematopoietic cell lineage. Affiliated tissues include bone, testes and skin, and related phenotypes are chest pain and bone pain

Wikipedia : 77 Eosinophilic granuloma is a form of Langerhans cell histiocytosis. It is a condition of both human and... more...

Related Diseases for Eosinophilic Granuloma

Diseases related to Eosinophilic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 32.3 BRAF CD1A
2 langerhans cell histiocytosis 32.2 BRAF CD1A
3 eosinophilic gastroenteritis 29.9 EPX RNASE3
4 hypereosinophilic syndrome 29.7 EPX RNASE3
5 pulmonary eosinophilia 29.7 EPX RNASE3
6 kimura disease 11.3
7 hashimoto-pritzker syndrome 11.2
8 letterer-siwe disease 10.3
9 eosinophilic cystitis 10.1 BRAF RNASE3
10 diabetes insipidus 10.1
11 ocular cicatricial pemphigoid 10.1 CD36 RNASE3
12 interstitial keratitis 10.1 CD36 DCN
13 inflammatory bowel disease 4 10.1 EPX RNASE3
14 odontogenic myxoma 10.1 CD36 DCN
15 conjunctival nevus 10.1 EPX RNASE3
16 torticollis 10.1
17 erdheim-chester disease 10.1
18 lipogranulomatosis 10.1
19 urinary schistosomiasis 10.1 EPX RNASE3
20 differentiated thyroid carcinoma 10.0 BRAF CD36
21 collagenous colitis 10.0 EPX RNASE3
22 pollen allergy 10.0 EPX RNASE3
23 proctitis 10.0 EPX RNASE3
24 vernal conjunctivitis 10.0 EPX RNASE3
25 conjunctivitis 10.0 EPX RNASE3
26 onchocerciasis 10.0 EPX RNASE3
27 brittle bone disorder 10.0 CD36 DCN
28 sarcoma 10.0
29 reticuloendotheliosis 10.0
30 food allergy 10.0 EPX RNASE3
31 bronchial disease 10.0 EPX RNASE3
32 gingival overgrowth 10.0 CD36 DCN
33 allergic asthma 9.9 EPX RNASE3
34 reticulum cell sarcoma 9.9
35 mental retardation, skeletal dysplasia, and abducens palsy 9.9
36 xanthomatosis 9.9
37 lymphoma 9.9
38 erythema elevatum diutinum 9.9
39 aggressive periodontitis 9.9
40 gastroenteritis 9.9
41 papillary carcinoma 9.9
42 pulmonary coin lesion 9.9
43 pneumonia 9.9
44 eosinophilic pneumonia 9.9
45 periodontitis 9.9
46 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9
47 lymphosarcoma 9.9
48 exophthalmos 9.9
49 eosinophilic enteropathy 9.9
50 allergic hypersensitivity disease 9.9 EPX RNASE3

Graphical network of the top 20 diseases related to Eosinophilic Granuloma:



Diseases related to Eosinophilic Granuloma

Symptoms & Phenotypes for Eosinophilic Granuloma

Human phenotypes related to Eosinophilic Granuloma:

60 33 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chest pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0100749
2 bone pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002653
3 osteolysis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002797
4 advanced eruption of teeth 60 33 hallmark (90%) Very frequent (99-80%) HP:0006288
5 increased susceptibility to fractures 60 33 hallmark (90%) Very frequent (99-80%) HP:0002659
6 abnormal oral mucosa morphology 33 hallmark (90%) HP:0011830
7 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
8 pulmonary infiltrates 60 33 frequent (33%) Frequent (79-30%) HP:0002113
9 chills 60 33 frequent (33%) Frequent (79-30%) HP:0025143
10 hyperhidrosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000975
11 chronic otitis media 60 33 occasional (7.5%) Occasional (29-5%) HP:0000389
12 joint swelling 60 33 occasional (7.5%) Occasional (29-5%) HP:0001386
13 dyspnea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002094
14 emphysema 60 33 occasional (7.5%) Occasional (29-5%) HP:0002097
15 pulmonary arterial hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0002092
16 hemiplegia/hemiparesis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004374
17 migraine 60 33 occasional (7.5%) Occasional (29-5%) HP:0002076
18 cachexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0004326
19 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
20 proptosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000520
21 lymphadenopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0002716
22 tapered finger 60 33 occasional (7.5%) Occasional (29-5%) HP:0001182
23 restrictive deficit on pulmonary function testing 60 33 occasional (7.5%) Occasional (29-5%) HP:0002111
24 obstructive deficit on pulmonary function testing 60 33 occasional (7.5%) Occasional (29-5%) HP:0030877
25 abnormality of the dentition 60 Very frequent (99-80%)
26 abnormality of oral mucosa 60 Very frequent (99-80%)

Drugs & Therapeutics for Eosinophilic Granuloma

Search Clinical Trials , NIH Clinical Center for Eosinophilic Granuloma

Genetic Tests for Eosinophilic Granuloma

Anatomical Context for Eosinophilic Granuloma

MalaCards organs/tissues related to Eosinophilic Granuloma:

42
Bone, Testes, Skin, Lymph Node, Thyroid, Kidney, Spleen

Publications for Eosinophilic Granuloma

Articles related to Eosinophilic Granuloma:

(show top 50) (show all 159)
# Title Authors Year
1
Langerhans cell histiocytosis presenting as eosinophilic granuloma of the bilateral forearms in an 8-year-old girl: a case report. ( 30885248 )
2019
2
<sup>18</sup>F FDG-PET/CT for the Evaluation of Primary Eosinophilic Granuloma of the Hypothalamus. ( 29724799 )
2018
3
Eosinophilic granuloma at the cerebellopontine angle in an adult; a rare case report and literature review. ( 28700967 )
2017
4
A Case of Multifocal Eosinophilic Granuloma Involving Spine and Pelvis in a Young Adult: A Radiopathological Correlation. ( 29333031 )
2017
5
Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings. ( 28274065 )
2017
6
A Case of Eosinophilic Granuloma Presenting as a Small Submucosal Tumor. ( 28458323 )
2017
7
A reply to the letter to the editor by Nima Derakhshan and Mahsa Roshanfarzad with regard to the paper &amp;quot;Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?&amp;quot; ( 28717831 )
2017
8
Eosinophilic Granuloma of Skull with Fluid Level and Epidural Hematoma: A Case Report and Review of the Literature. ( 27595542 )
2017
9
Cerebello-pontine angle eosinophilic granuloma; a reappraisal in the management of intracranial eosinophilic granuloma. ( 28646263 )
2017
10
Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases. ( 28490189 )
2017
11
The outcome of eosinophilic granuloma involving unilateral atlantoaxial joint: A case report and literature review. ( 28640106 )
2017
12
Remarkable improvement in mitral valve regurgitation in paediatric eosinophilic granuloma with polyangiitis. ( 28552076 )
2017
13
Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma. ( 28361364 )
2017
14
Management of eosinophilic granuloma in pediatric patients: surgical intervention and surgery combined with postoperative radiotherapy and/or chemotherapy. ( 28247113 )
2017
15
[Eosinophilic granuloma of the parietal bone of an adult patient with BRAF mutation]. ( 28791997 )
2017
16
Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. ( 29114286 )
2017
17
Spontaneous improvement of cervical kyphosis in eosinophilic granuloma: a case report. ( 27898494 )
2017
18
Reconstruction of the C-1 lateral mass with a titanium expandable cage after resection of eosinophilic granuloma in an adult patient. ( 27716017 )
2016
19
Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control? ( 26999697 )
2016
20
Spontaneous resolution of an eosinophilic granuloma of the mandible following open biopsy. ( 27033671 )
2016
21
Eosinophilic granuloma of the sacrum treated with radiation therapy: a case report. ( 26386170 )
2016
22
Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it? ( 26661575 )
2016
23
Eosinophilic granuloma of the lumbar spine in a child. ( 26723260 )
2016
24
A Novel Surgical Approach to Coracoid-based Eosinophilic Granuloma and the Technical Trick. ( 27280752 )
2016
25
Eosinophilic granuloma with Splendore-Hoeppli material caused by Mannheimia granulomatis in a calf. ( 26947171 )
2016
26
Current concepts for the diagnosis and management of eosinophilic granuloma of bone. ( 27770337 )
2016
27
Eosinophilic Granuloma Presenting as Palatal Swelling. ( 27891486 )
2016
28
The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability. ( 27923375 )
2016
29
Eosinophilic Granuloma in Jaw Bone: A Pare Pediatric Case Report. ( 28446855 )
2016
30
Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil. ( 27374751 )
2016
31
Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: a case report. ( 27251410 )
2016
32
Short Segment Stabilization by Protecting the Alar Ligaments in a Case of Eosinophilic Granuloma Involving the C2 Spine. ( 27032524 )
2016
33
MEDICAL MANAGEMENT OF RECURRENT EOSINOPHILIC GRANULOMA IN TWO BLACK RHINOCEROS (DICEROS BICORNIS). ( 27691969 )
2016
34
Emperipolesis in eosinophilic granuloma of the skull. ( 27191911 )
2016
35
Facial involutive tumors: A case of tumor-like eosinophilic granuloma of the skin. ( 26728823 )
2016
36
Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case. ( 26414822 )
2015
37
A Right Middle Cerebral Artery Infarct After Frontal Eosinophilic Granuloma Resection in an 8-Year-Old Boy with Factor V Leiden. ( 26442559 )
2015
38
Healing calvarial eosinophilic granuloma or healing skull fracture? ( 25837576 )
2015
39
PET/CT positive in a case with eosinophilic granuloma. ( 26523904 )
2015
40
Solitary eosinophilic granuloma of mandibular condyle: literature review and report of a rare case. ( 25861187 )
2015
41
Eosinophilic granuloma/Langerhans cell histiocytosis: Pediatric neurosurgery update. ( 26539317 )
2015
42
Rapid Growing Eosinophilic Granuloma in Skull after Minor Trauma. ( 27169061 )
2015
43
ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer. ( 26107936 )
2015
44
Eosinophilic granuloma of the cervical spine manifesting as torticollis in a child. ( 25667698 )
2014
45
Primary Hodgkin disease of the spine could mimic eosinophilic granuloma initially. ( 24034117 )
2013
46
Erdheim-Chester disease--a rare differential diagnosis of eosinophilic granuloma: a case report. ( 22467484 )
2012
47
Pulmonary Langerhans cell histiocytosis and eosinophilic granuloma. ( 22880529 )
2012
48
Operative case of Langerhans'cell histiocytosis of the skull with dural invasion. An immunohystochemical study of ki-67 expression of eosinophilic granuloma: case report and review of the literature. ( 22415385 )
2012
49
Orbital Rosai-Dorfman disease with subperiosteal bone involvement mimicking eosinophilic granuloma. ( 22085401 )
2012
50
Detection of feline herpes virus 1 via polymerase chain reaction and immunohistochemistry in cats with ulcerative facial dermatitis, eosinophilic granuloma complex reaction patterns and mosquito bite hypersensitivity. ( 21651631 )
2011

Variations for Eosinophilic Granuloma

Expression for Eosinophilic Granuloma

Search GEO for disease gene expression data for Eosinophilic Granuloma.

Pathways for Eosinophilic Granuloma

Pathways related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 BRAF CD1A CD36 EPX RNASE3
2 10.61 CD1A CD36

GO Terms for Eosinophilic Granuloma

Cellular components related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CD36 DCN EPX RNASE3

Biological processes related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 BRAF DCN
2 defense response to Gram-positive bacterium GO:0050830 8.96 CD36 RNASE3
3 neutrophil degranulation GO:0043312 8.8 CD36 EPX RNASE3

Sources for Eosinophilic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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