MCID: ESN017
MIFTS: 42

Eosinophilic Granuloma

Categories: Blood diseases, Bone diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Eosinophilic Granuloma

Summaries for Eosinophilic Granuloma

MalaCards based summary : Eosinophilic Granuloma, also known as chronic and localized langerhans cell histiocytosis, is related to histiocytosis and langerhans cell histiocytosis. An important gene associated with Eosinophilic Granuloma is CD1A (CD1a Molecule), and among its related pathways/superpathways are Innate Immune System and Hematopoietic cell lineage. Affiliated tissues include bone, lung and skin, and related phenotypes are hyperhidrosis and chronic otitis media

Wikipedia : 76 Eosinophilic granuloma is a form of Langerhans cell histiocytosis. It is a condition of both human and... more...

Related Diseases for Eosinophilic Granuloma

Diseases related to Eosinophilic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 32.3 BRAF CD1A
2 langerhans cell histiocytosis 32.2 BRAF CD1A
3 eosinophilic gastroenteritis 29.8 EPX RNASE3
4 pulmonary eosinophilia 29.6 EPX RNASE3
5 hypereosinophilic syndrome 29.4 EPX RNASE3
6 kimura disease 11.2
7 hashimoto-pritzker syndrome 11.2
8 letterer-siwe disease 10.3
9 diabetes insipidus 10.1
10 sarcoma 10.1
11 interstitial keratitis 10.1 CD36 DCN
12 odontogenic myxoma 10.1 CD36 DCN
13 eosinophilic cystitis 10.1 BRAF RNASE3
14 ocular cicatricial pemphigoid 10.1 CD36 RNASE3
15 torticollis 10.0
16 erdheim-chester disease 10.0
17 periodontitis 10.0
18 lipogranulomatosis 10.0
19 brittle bone disorder 10.0 CD36 DCN
20 differentiated thyroid carcinoma 10.0 BRAF CD36
21 gingival overgrowth 10.0 CD36 DCN
22 inflammatory bowel disease 4 10.0 EPX RNASE3
23 conjunctival nevus 10.0 EPX RNASE3
24 urinary schistosomiasis 10.0 EPX RNASE3
25 collagenous colitis 10.0 EPX RNASE3
26 pollen allergy 10.0 EPX RNASE3
27 proctitis 10.0 EPX RNASE3
28 vernal conjunctivitis 10.0 EPX RNASE3
29 conjunctivitis 10.0 EPX RNASE3
30 lymphoma 10.0
31 reticuloendotheliosis 10.0
32 onchocerciasis 10.0 EPX RNASE3
33 food allergy 9.9 EPX RNASE3
34 bronchial disease 9.9 EPX RNASE3
35 allergic asthma 9.9 EPX RNASE3
36 reticulum cell sarcoma 9.9
37 mental retardation, skeletal dysplasia, and abducens palsy 9.9
38 xanthomatosis 9.9
39 erythema elevatum diutinum 9.9
40 aggressive periodontitis 9.9
41 pneumothorax 9.9
42 melanoma 9.9
43 gastroenteritis 9.9
44 papillary carcinoma 9.9
45 periodontal disease 9.9
46 pulmonary coin lesion 9.9
47 pneumonia 9.9
48 eosinophilic pneumonia 9.9
49 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9
50 lymphosarcoma 9.9

Graphical network of the top 20 diseases related to Eosinophilic Granuloma:



Diseases related to Eosinophilic Granuloma

Symptoms & Phenotypes for Eosinophilic Granuloma

Human phenotypes related to Eosinophilic Granuloma:

59 32 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000975
2 chronic otitis media 59 32 occasional (7.5%) Occasional (29-5%) HP:0000389
3 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
4 joint swelling 59 32 occasional (7.5%) Occasional (29-5%) HP:0001386
5 dyspnea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002094
6 emphysema 59 32 occasional (7.5%) Occasional (29-5%) HP:0002097
7 pulmonary arterial hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002092
8 hemiplegia/hemiparesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004374
9 migraine 59 32 occasional (7.5%) Occasional (29-5%) HP:0002076
10 cachexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0004326
11 chest pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0100749
12 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
13 bone pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002653
14 proptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000520
15 osteolysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002797
16 lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002716
17 tapered finger 59 32 occasional (7.5%) Occasional (29-5%) HP:0001182
18 advanced eruption of teeth 59 32 hallmark (90%) Very frequent (99-80%) HP:0006288
19 restrictive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0002111
20 pulmonary infiltrates 59 32 frequent (33%) Frequent (79-30%) HP:0002113
21 increased susceptibility to fractures 59 32 hallmark (90%) Very frequent (99-80%) HP:0002659
22 chills 59 32 frequent (33%) Frequent (79-30%) HP:0025143
23 obstructive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0030877
24 abnormality of the dentition 59 Very frequent (99-80%)
25 abnormality of oral mucosa 59 Very frequent (99-80%)
26 abnormal oral mucosa morphology 32 hallmark (90%) HP:0011830

Drugs & Therapeutics for Eosinophilic Granuloma

Search Clinical Trials , NIH Clinical Center for Eosinophilic Granuloma

Genetic Tests for Eosinophilic Granuloma

Anatomical Context for Eosinophilic Granuloma

MalaCards organs/tissues related to Eosinophilic Granuloma:

41
Bone, Lung, Skin, Testes, Lymph Node, Kidney, Thyroid

Publications for Eosinophilic Granuloma

Articles related to Eosinophilic Granuloma:

(show top 50) (show all 922)
# Title Authors Year
1
<sup>18</sup>F FDG-PET/CT for the Evaluation of Primary Eosinophilic Granuloma of the Hypothalamus. ( 29724799 )
2018
2
Eosinophilic granuloma of the spine involving C1 and pulmonary infiltration in young children - Presentation of two cases with a follow-up over 10 years including review of the literature. ( 30147276 )
2018
3
Multidisciplinary rehabilitation of eosinophilic granuloma with bone graft surgery and a modified implant-supported hybrid prosthesis: A case report with a 6-year follow-up. ( 30431184 )
2018
4
Eosinophilic granuloma at the cerebellopontine angle in an adult; a rare case report and literature review. ( 28700967 )
2017
5
A Case of Multifocal Eosinophilic Granuloma Involving Spine and Pelvis in a Young Adult: A Radiopathological Correlation. ( 29333031 )
2017
6
Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings. ( 28274065 )
2017
7
A Case of Eosinophilic Granuloma Presenting as a Small Submucosal Tumor. ( 28458323 )
2017
8
A reply to the letter to the editor by Nima Derakhshan and Mahsa Roshanfarzad with regard to the paper &amp;quot;Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?&amp;quot; ( 28717831 )
2017
9
Eosinophilic Granuloma of Skull with Fluid Level and Epidural Hematoma: A Case Report and Review of the Literature. ( 27595542 )
2017
10
Cerebello-pontine angle eosinophilic granuloma; a reappraisal in the management of intracranial eosinophilic granuloma. ( 28646263 )
2017
11
Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases. ( 28490189 )
2017
12
The outcome of eosinophilic granuloma involving unilateral atlantoaxial joint: A case report and literature review. ( 28640106 )
2017
13
Remarkable improvement in mitral valve regurgitation in paediatric eosinophilic granuloma with polyangiitis. ( 28552076 )
2017
14
Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma. ( 28361364 )
2017
15
Management of eosinophilic granuloma in pediatric patients: surgical intervention and surgery combined with postoperative radiotherapy and/or chemotherapy. ( 28247113 )
2017
16
[Eosinophilic granuloma of the parietal bone of an adult patient with BRAF mutation]. ( 28791997 )
2017
17
Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. ( 29114286 )
2017
18
Spontaneous improvement of cervical kyphosis in eosinophilic granuloma: a case report. ( 27898494 )
2017
19
Reconstruction of the C-1 lateral mass with a titanium expandable cage after resection of eosinophilic granuloma in an adult patient. ( 27716017 )
2016
20
Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control? ( 26999697 )
2016
21
Spontaneous resolution of an eosinophilic granuloma of the mandible following open biopsy. ( 27033671 )
2016
22
Eosinophilic granuloma of the sacrum treated with radiation therapy: a case report. ( 26386170 )
2016
23
Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it? ( 26661575 )
2016
24
Eosinophilic granuloma of the lumbar spine in a child. ( 26723260 )
2016
25
A Novel Surgical Approach to Coracoid-based Eosinophilic Granuloma and the Technical Trick. ( 27280752 )
2016
26
Eosinophilic granuloma with Splendore-Hoeppli material caused by Mannheimia granulomatis in a calf. ( 26947171 )
2016
27
Current concepts for the diagnosis and management of eosinophilic granuloma of bone. ( 27770337 )
2016
28
Eosinophilic Granuloma Presenting as Palatal Swelling. ( 27891486 )
2016
29
The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability. ( 27923375 )
2016
30
Eosinophilic Granuloma in Jaw Bone: A Pare Pediatric Case Report. ( 28446855 )
2016
31
Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil. ( 27374751 )
2016
32
Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: a case report. ( 27251410 )
2016
33
Short Segment Stabilization by Protecting the Alar Ligaments in a Case of Eosinophilic Granuloma Involving the C2 Spine. ( 27032524 )
2016
34
MEDICAL MANAGEMENT OF RECURRENT EOSINOPHILIC GRANULOMA IN TWO BLACK RHINOCEROS (DICEROS BICORNIS). ( 27691969 )
2016
35
Emperipolesis in eosinophilic granuloma of the skull. ( 27191911 )
2016
36
Facial involutive tumors: A case of tumor-like eosinophilic granuloma of the skin. ( 26728823 )
2016
37
Intralesional Injection of Interferon-α2b in Orbital Eosinophilic Granuloma. ( 25226096 )
2016
38
Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case. ( 26414822 )
2015
39
A Right Middle Cerebral Artery Infarct After Frontal Eosinophilic Granuloma Resection in an 8-Year-Old Boy with Factor V Leiden. ( 26442559 )
2015
40
Healing calvarial eosinophilic granuloma or healing skull fracture? ( 25837576 )
2015
41
PET/CT positive in a case with eosinophilic granuloma. ( 26523904 )
2015
42
Solitary eosinophilic granuloma of mandibular condyle: literature review and report of a rare case. ( 25861187 )
2015
43
Eosinophilic granuloma/Langerhans cell histiocytosis: Pediatric neurosurgery update. ( 26539317 )
2015
44
Rapid Growing Eosinophilic Granuloma in Skull after Minor Trauma. ( 27169061 )
2015
45
Eosinophilic granuloma of the skull base: patient with unique clinical moreover, radiographic presentation. ( 25597609 )
2015
46
Eosinophilic granuloma of mandibular condyle: resection and complete regeneration. ( 25729234 )
2015
47
Skull fracture mimicking eosinophilic granuloma. ( 25758644 )
2015
48
Adult onset asynchronous multifocal eosinophilic granuloma of bone: an 11-year follow-up. ( 25793108 )
2015
49
Eosinophilic granuloma with Splendore-Hoeppli material caused by toxigenic Corynebacterium ulcerans in a heifer. ( 24632861 )
2014
50
Atlantoaxial instability secondary to eosinophilic granuloma of the axis in adults: long-term follow-up in six cases. ( 24647385 )
2014

Variations for Eosinophilic Granuloma

Expression for Eosinophilic Granuloma

Search GEO for disease gene expression data for Eosinophilic Granuloma.

Pathways for Eosinophilic Granuloma

Pathways related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 BRAF CD1A CD36 EPX RNASE3
2 10.61 CD1A CD36

GO Terms for Eosinophilic Granuloma

Cellular components related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CD36 DCN EPX RNASE3

Biological processes related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 BRAF DCN
2 defense response to Gram-positive bacterium GO:0050830 8.96 CD36 RNASE3
3 neutrophil degranulation GO:0043312 8.8 CD36 EPX RNASE3

Sources for Eosinophilic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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