MCID: ESN017
MIFTS: 38

Eosinophilic Granuloma

Categories: Respiratory diseases, Bone diseases, Blood diseases, Rare diseases

Aliases & Classifications for Eosinophilic Granuloma

Summaries for Eosinophilic Granuloma

MalaCards based summary : Eosinophilic Granuloma, also known as chronic and localized langerhans cell histiocytosis, is related to langerhans cell histiocytosis and histiocytosis. An important gene associated with Eosinophilic Granuloma is CD1A (CD1a Molecule), and among its related pathways/superpathways are Innate Immune System and Hematopoietic cell lineage. Affiliated tissues include bone, testes and lung, and related phenotypes are hyperhidrosis and chronic otitis media

Wikipedia : 76 Eosinophilic granuloma is a form of Langerhans cell histiocytosis. It is a condition of both human and... more...

Related Diseases for Eosinophilic Granuloma

Diseases related to Eosinophilic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 langerhans cell histiocytosis 31.7 BRAF CD1A
2 histiocytosis 31.6 BRAF CD1A
3 eosinophilic gastroenteritis 29.7 EPX RNASE3
4 pulmonary eosinophilia 29.4 EPX RNASE3
5 kimura disease 11.1
6 hashimoto-pritzker syndrome 11.0
7 interstitial keratitis 10.3 CD36 DCN
8 odontogenic myxoma 10.3 CD36 DCN
9 ocular cicatricial pemphigoid 10.2 CD36 RNASE3
10 letterer-siwe disease 10.2
11 gingival overgrowth 10.1 CD36 DCN
12 brittle bone disorder 10.1 CD36 DCN
13 differentiated thyroid carcinoma 10.1 BRAF CD36
14 inflammatory bowel disease 4 10.0 EPX RNASE3
15 conjunctival nevus 10.0 EPX RNASE3
16 urinary schistosomiasis 10.0 EPX RNASE3
17 collagenous colitis 10.0 EPX RNASE3
18 pollen allergy 10.0 EPX RNASE3
19 proctitis 10.0 EPX RNASE3
20 onchocerciasis 10.0 EPX RNASE3
21 vernal conjunctivitis 9.9 EPX RNASE3
22 lipogranulomatosis 9.9
23 erdheim-chester disease 9.9
24 leukocyte disease 9.9 EPX RNASE3
25 conjunctivitis 9.9 EPX RNASE3
26 cervicitis 9.9
27 food allergy 9.9 EPX RNASE3
28 bronchial disease 9.8 EPX RNASE3
29 erythema elevatum diutinum 9.8
30 aggressive periodontitis 9.8
31 gastroenteritis 9.8
32 eosinophilic enteropathy 9.8
33 reticuloendotheliosis 9.8
34 pneumonia 9.8
35 eosinophilic pneumonia 9.8
36 hepatitis 9.8
37 periodontitis 9.8
38 allergic hypersensitivity disease 9.7 EPX RNASE3
39 allergic asthma 9.7 EPX RNASE3
40 reticulosarcoma 9.6
41 chronic eosinophilic pneumonia 9.6
42 psychotic disorder 9.6
43 dermatitis 9.6
44 myelitis 9.6
45 rosai-dorfman disease 9.6
46 cerebritis 9.6
47 transverse myelitis 9.6
48 headache 9.6
49 torticollis 9.6
50 acute transverse myelitis 9.6

Graphical network of the top 20 diseases related to Eosinophilic Granuloma:



Diseases related to Eosinophilic Granuloma

Symptoms & Phenotypes for Eosinophilic Granuloma

Human phenotypes related to Eosinophilic Granuloma:

59 32 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperhidrosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000975
2 chronic otitis media 59 32 occasional (7.5%) Occasional (29-5%) HP:0000389
3 fatigue 59 32 frequent (33%) Frequent (79-30%) HP:0012378
4 joint swelling 59 32 occasional (7.5%) Occasional (29-5%) HP:0001386
5 dyspnea 59 32 occasional (7.5%) Occasional (29-5%) HP:0002094
6 emphysema 59 32 occasional (7.5%) Occasional (29-5%) HP:0002097
7 pulmonary arterial hypertension 59 32 occasional (7.5%) Occasional (29-5%) HP:0002092
8 hemiplegia/hemiparesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004374
9 migraine 59 32 occasional (7.5%) Occasional (29-5%) HP:0002076
10 cachexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0004326
11 chest pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0100749
12 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
13 bone pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002653
14 proptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000520
15 osteolysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0002797
16 lymphadenopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002716
17 tapered finger 59 32 occasional (7.5%) Occasional (29-5%) HP:0001182
18 advanced eruption of teeth 59 32 hallmark (90%) Very frequent (99-80%) HP:0006288
19 pulmonary infiltrates 59 32 frequent (33%) Frequent (79-30%) HP:0002113
20 restrictive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0002111
21 increased susceptibility to fractures 59 32 hallmark (90%) Very frequent (99-80%) HP:0002659
22 chills 59 32 frequent (33%) Frequent (79-30%) HP:0025143
23 obstructive deficit on pulmonary function testing 59 32 occasional (7.5%) Occasional (29-5%) HP:0030877
24 abnormality of the dentition 59 Very frequent (99-80%)
25 abnormality of oral mucosa 59 Very frequent (99-80%)
26 abnormal oral mucosa morphology 32 hallmark (90%) HP:0011830

Drugs & Therapeutics for Eosinophilic Granuloma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases Completed NCT00366509

Search NIH Clinical Center for Eosinophilic Granuloma

Genetic Tests for Eosinophilic Granuloma

Anatomical Context for Eosinophilic Granuloma

MalaCards organs/tissues related to Eosinophilic Granuloma:

41
Bone, Testes, Lung, Skin, Hypothalamus

Publications for Eosinophilic Granuloma

Articles related to Eosinophilic Granuloma:

(show top 50) (show all 86)
# Title Authors Year
1
<sup>18</sup>F FDG-PET/CT for the Evaluation of Primary Eosinophilic Granuloma of the Hypothalamus. ( 29724799 )
2018
2
Eosinophilic granuloma at the cerebellopontine angle in an adult; a rare case report and literature review. ( 28700967 )
2017
3
A Case of Multifocal Eosinophilic Granuloma Involving Spine and Pelvis in a Young Adult: A Radiopathological Correlation. ( 29333031 )
2017
4
Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings. ( 28274065 )
2017
5
A Case of Eosinophilic Granuloma Presenting as a Small Submucosal Tumor. ( 28458323 )
2017
6
A reply to the letter to the editor by Nima Derakhshan and Mahsa Roshanfarzad with regard to the paper &amp;quot;Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?&amp;quot; ( 28717831 )
2017
7
Eosinophilic Granuloma of Skull with Fluid Level and Epidural Hematoma: A Case Report and Review of the Literature. ( 27595542 )
2017
8
Cerebello-pontine angle eosinophilic granuloma; a reappraisal in the management of intracranial eosinophilic granuloma. ( 28646263 )
2017
9
Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases. ( 28490189 )
2017
10
The outcome of eosinophilic granuloma involving unilateral atlantoaxial joint: A case report and literature review. ( 28640106 )
2017
11
Remarkable improvement in mitral valve regurgitation in paediatric eosinophilic granuloma with polyangiitis. ( 28552076 )
2017
12
Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma. ( 28361364 )
2017
13
Management of eosinophilic granuloma in pediatric patients: surgical intervention and surgery combined with postoperative radiotherapy and/or chemotherapy. ( 28247113 )
2017
14
[Eosinophilic granuloma of the parietal bone of an adult patient with BRAF mutation]. ( 28791997 )
2017
15
Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. ( 29114286 )
2017
16
Spontaneous improvement of cervical kyphosis in eosinophilic granuloma: a case report. ( 27898494 )
2017
17
Reconstruction of the C-1 lateral mass with a titanium expandable cage after resection of eosinophilic granuloma in an adult patient. ( 27716017 )
2016
18
Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control? ( 26999697 )
2016
19
Spontaneous resolution of an eosinophilic granuloma of the mandible following open biopsy. ( 27033671 )
2016
20
Eosinophilic granuloma of the sacrum treated with radiation therapy: a case report. ( 26386170 )
2016
21
Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it? ( 26661575 )
2016
22
Eosinophilic granuloma of the lumbar spine in a child. ( 26723260 )
2016
23
A Novel Surgical Approach to Coracoid-based Eosinophilic Granuloma and the Technical Trick. ( 27280752 )
2016
24
Eosinophilic granuloma with Splendore-Hoeppli material caused by Mannheimia granulomatis in a calf. ( 26947171 )
2016
25
Current concepts for the diagnosis and management of eosinophilic granuloma of bone. ( 27770337 )
2016
26
Eosinophilic Granuloma Presenting as Palatal Swelling. ( 27891486 )
2016
27
The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability. ( 27923375 )
2016
28
Eosinophilic Granuloma in Jaw Bone: A Pare Pediatric Case Report. ( 28446855 )
2016
29
Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil. ( 27374751 )
2016
30
Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: a case report. ( 27251410 )
2016
31
Short Segment Stabilization by Protecting the Alar Ligaments in a Case of Eosinophilic Granuloma Involving the C2 Spine. ( 27032524 )
2016
32
MEDICAL MANAGEMENT OF RECURRENT EOSINOPHILIC GRANULOMA IN TWO BLACK RHINOCEROS (DICEROS BICORNIS). ( 27691969 )
2016
33
Emperipolesis in eosinophilic granuloma of the skull. ( 27191911 )
2016
34
Facial involutive tumors: A case of tumor-like eosinophilic granuloma of the skin. ( 26728823 )
2016
35
Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case. ( 26414822 )
2015
36
A Right Middle Cerebral Artery Infarct After Frontal Eosinophilic Granuloma Resection in an 8-Year-Old Boy with Factor V Leiden. ( 26442559 )
2015
37
Healing calvarial eosinophilic granuloma or healing skull fracture? ( 25837576 )
2015
38
PET/CT positive in a case with eosinophilic granuloma. ( 26523904 )
2015
39
Solitary eosinophilic granuloma of mandibular condyle: literature review and report of a rare case. ( 25861187 )
2015
40
Eosinophilic granuloma/Langerhans cell histiocytosis: Pediatric neurosurgery update. ( 26539317 )
2015
41
Rapid Growing Eosinophilic Granuloma in Skull after Minor Trauma. ( 27169061 )
2015
42
Monosystem multifocal Langerhans cell histiocytosis (multifocal eosinophilic granulomas of the bone) in a 36-year old patient: case report, therapeutic doubts and review of literature. ( 23940999 )
2013
43
Erdheim-Chester disease--a rare differential diagnosis of eosinophilic granuloma: a case report. ( 22467484 )
2012
44
Pulmonary Langerhans cell histiocytosis and eosinophilic granuloma. ( 22880529 )
2012
45
Operative case of Langerhans'cell histiocytosis of the skull with dural invasion. An immunohystochemical study of ki-67 expression of eosinophilic granuloma: case report and review of the literature. ( 22415385 )
2012
46
Orbital Rosai-Dorfman disease with subperiosteal bone involvement mimicking eosinophilic granuloma. ( 22085401 )
2012
47
Detection of feline herpes virus 1 via polymerase chain reaction and immunohistochemistry in cats with ulcerative facial dermatitis, eosinophilic granuloma complex reaction patterns and mosquito bite hypersensitivity. ( 21651631 )
2011
48
Eosinophilic granuloma: resolution of lesion after biopsy. ( 22134295 )
2011
49
Langerhans cell histiocytosis (eosinophilic granuloma). ( 22128475 )
2011
50
Spontaneous resolution of eosinophilic granuloma in a patient with a psychotic disorder. ( 24148635 )
2010

Variations for Eosinophilic Granuloma

Expression for Eosinophilic Granuloma

Search GEO for disease gene expression data for Eosinophilic Granuloma.

Pathways for Eosinophilic Granuloma

Pathways related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 BRAF CD1A CD36 EPX RNASE3
2 10.61 CD1A CD36

GO Terms for Eosinophilic Granuloma

Cellular components related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CD36 DCN EPX RNASE3

Biological processes related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 BRAF DCN
2 defense response to Gram-positive bacterium GO:0050830 8.96 CD36 RNASE3
3 neutrophil degranulation GO:0043312 8.8 CD36 EPX RNASE3

Sources for Eosinophilic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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