MCID: ESN017
MIFTS: 40

Eosinophilic Granuloma

Categories: Blood diseases, Bone diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Eosinophilic Granuloma

Summaries for Eosinophilic Granuloma

MalaCards based summary : Eosinophilic Granuloma, also known as chronic and localized langerhans cell histiocytosis, is related to histiocytosis and langerhans cell histiocytosis. An important gene associated with Eosinophilic Granuloma is CD1A (CD1a Molecule), and among its related pathways/superpathways are Innate Immune System and Hematopoietic cell lineage. Affiliated tissues include bone, lung and skin, and related phenotypes are chest pain and bone pain

Wikipedia : 77 Eosinophilic granuloma is a form of Langerhans cell histiocytosis. It is a condition of both human and... more...

Related Diseases for Eosinophilic Granuloma

Diseases related to Eosinophilic Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 32.3 BRAF CD1A
2 langerhans cell histiocytosis 32.2 BRAF CD1A
3 eosinophilic gastroenteritis 30.0 EPX RNASE3
4 hypereosinophilic syndrome 29.9 EPX RNASE3
5 pulmonary eosinophilia 29.7 EPX RNASE3
6 kimura disease 11.3
7 hashimoto-pritzker syndrome 11.2
8 letterer-siwe disease 10.3
9 diabetes insipidus 10.2
10 eosinophilic cystitis 10.1 BRAF RNASE3
11 sarcoma 10.1
12 inflammatory bowel disease 4 10.1 EPX RNASE3
13 conjunctival nevus 10.1 EPX RNASE3
14 urinary schistosomiasis 10.1 EPX RNASE3
15 collagenous colitis 10.1 EPX RNASE3
16 pollen allergy 10.1 EPX RNASE3
17 proctitis 10.1 EPX RNASE3
18 vernal conjunctivitis 10.1 EPX RNASE3
19 conjunctivitis 10.1 EPX RNASE3
20 torticollis 10.1
21 erdheim-chester disease 10.1
22 periodontitis 10.1
23 lipogranulomatosis 10.1
24 onchocerciasis 10.1 EPX RNASE3
25 food allergy 10.0 EPX RNASE3
26 bronchial disease 10.0 EPX RNASE3
27 interstitial keratitis 10.0 CD36 DCN
28 lymphoma 10.0
29 reticuloendotheliosis 10.0
30 odontogenic myxoma 10.0 CD36 DCN
31 allergic asthma 10.0 EPX RNASE3
32 ocular cicatricial pemphigoid 10.0 CD36 RNASE3
33 differentiated thyroid carcinoma 10.0 BRAF CD36
34 brittle bone disorder 9.9 CD36 DCN
35 allergic hypersensitivity disease 9.9 EPX RNASE3
36 reticulum cell sarcoma 9.9
37 mental retardation, skeletal dysplasia, and abducens palsy 9.9
38 xanthomatosis 9.9
39 erythema elevatum diutinum 9.9
40 lymphoproliferative syndrome 9.9
41 aggressive periodontitis 9.9
42 pneumothorax 9.9
43 melanoma 9.9
44 gastroenteritis 9.9
45 papillary carcinoma 9.9
46 periodontal disease 9.9
47 pulmonary coin lesion 9.9
48 pneumonia 9.9
49 eosinophilic pneumonia 9.9
50 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9

Graphical network of the top 20 diseases related to Eosinophilic Granuloma:



Diseases related to Eosinophilic Granuloma

Symptoms & Phenotypes for Eosinophilic Granuloma

Human phenotypes related to Eosinophilic Granuloma:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 chest pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0100749
2 bone pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002653
3 osteolysis 60 33 hallmark (90%) Very frequent (99-80%) HP:0002797
4 advanced eruption of teeth 60 33 hallmark (90%) Very frequent (99-80%) HP:0006288
5 increased susceptibility to fractures 60 33 hallmark (90%) Very frequent (99-80%) HP:0002659
6 abnormal oral mucosa morphology 33 hallmark (90%) HP:0011830
7 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
8 pulmonary infiltrates 60 33 frequent (33%) Frequent (79-30%) HP:0002113
9 chills 60 33 frequent (33%) Frequent (79-30%) HP:0025143
10 hyperhidrosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000975
11 chronic otitis media 60 33 occasional (7.5%) Occasional (29-5%) HP:0000389
12 joint swelling 60 33 occasional (7.5%) Occasional (29-5%) HP:0001386
13 dyspnea 60 33 occasional (7.5%) Occasional (29-5%) HP:0002094
14 emphysema 60 33 occasional (7.5%) Occasional (29-5%) HP:0002097
15 pulmonary arterial hypertension 60 33 occasional (7.5%) Occasional (29-5%) HP:0002092
16 hemiplegia/hemiparesis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004374
17 migraine 60 33 occasional (7.5%) Occasional (29-5%) HP:0002076
18 cachexia 60 33 occasional (7.5%) Occasional (29-5%) HP:0004326
19 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
20 proptosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000520
21 lymphadenopathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0002716
22 tapered finger 60 33 occasional (7.5%) Occasional (29-5%) HP:0001182
23 restrictive deficit on pulmonary function testing 60 33 occasional (7.5%) Occasional (29-5%) HP:0002111
24 reduced fev1/fvc ratio 33 occasional (7.5%) HP:0030877
25 abnormality of the dentition 60 Very frequent (99-80%)
26 abnormality of oral mucosa 60 Very frequent (99-80%)
27 obstructive deficit on pulmonary function testing 60 Occasional (29-5%)

Drugs & Therapeutics for Eosinophilic Granuloma

Search Clinical Trials , NIH Clinical Center for Eosinophilic Granuloma

Genetic Tests for Eosinophilic Granuloma

Anatomical Context for Eosinophilic Granuloma

MalaCards organs/tissues related to Eosinophilic Granuloma:

42
Bone, Lung, Skin, Testes, Lymph Node, Kidney, Tongue

Publications for Eosinophilic Granuloma

Articles related to Eosinophilic Granuloma:

(show top 50) (show all 928)
# Title Authors Year
1
Langerhans cell histiocytosis presenting as eosinophilic granuloma of the bilateral forearms in an 8-year-old girl: a case report. ( 30885248 )
2019
2
Cone Beam CT study of a case of eosinophilic granuloma of the mandible in a young patient. ( 31061179 )
2019
3
Incidence and radiological pattern of eosinophilic granuloma: a retrospective study in a Chinese tertiary hospital. ( 31072377 )
2019
4
Multidisciplinary rehabilitation of eosinophilic granuloma with bone graft surgery and a modified implant-supported hybrid prosthesis: A case report with a 6-year follow-up. ( 30431184 )
2019
5
Eosinophilic granuloma of the cervical spine in adults: A review. ( 30771538 )
2019
6
Langerhans cell histiocytosis (eosinophilic granuloma) of the skull mimicking nummular headache. Report of two cases. ( 28490189 )
2018
7
18F-FDG PET/CT for the Evaluation of Primary Eosinophilic Granuloma of the Hypothalamus. ( 29724799 )
2018
8
Eosinophilic granuloma of the spine involving C1 and pulmonary infiltration in young children - Presentation of two cases with a follow-up over 10 years including review of the literature. ( 30147276 )
2018
9
Eosinophilic Granuloma of Mandible: A Diagnostic Challenge. ( 30636766 )
2018
10
Eosinophilic Granuloma of Skull with Fluid Level and Epidural Hematoma: A Case Report and Review of the Literature. ( 27595542 )
2017
11
Reconstruction of the C-1 lateral mass with a titanium expandable cage after resection of eosinophilic granuloma in an adult patient. ( 27716017 )
2017
12
Current concepts for the diagnosis and management of eosinophilic granuloma of bone. ( 27770337 )
2017
13
Spontaneous improvement of cervical kyphosis in eosinophilic granuloma: a case report. ( 27898494 )
2017
14
Management of eosinophilic granuloma in pediatric patients: surgical intervention and surgery combined with postoperative radiotherapy and/or chemotherapy. ( 28247113 )
2017
15
Multifocal Eosinophilic Granuloma of Jaws and Skull with Classical and Unusual Radiographic/Imaging Findings. ( 28274065 )
2017
16
Spontaneous and complete regeneration of a vertebra plana after surgical curettage of an eosinophilic granuloma. ( 28361364 )
2017
17
A Case of Eosinophilic Granuloma Presenting as a Small Submucosal Tumor. ( 28458323 )
2017
18
Remarkable improvement in mitral valve regurgitation in paediatric eosinophilic granuloma with polyangiitis. ( 28552076 )
2017
19
The outcome of eosinophilic granuloma involving unilateral atlantoaxial joint: A case report and literature review. ( 28640106 )
2017
20
Cerebello-pontine angle eosinophilic granuloma; a reappraisal in the management of intracranial eosinophilic granuloma. ( 28646263 )
2017
21
Eosinophilic granuloma at the cerebellopontine angle in an adult; a rare case report and literature review. ( 28700967 )
2017
22
A reply to the letter to the editor by Nima Derakhshan and Mahsa Roshanfarzad with regard to the paper "Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it?" ( 28717831 )
2017
23
Intradural Eosinophilic Granuloma Invading Skull: Case Report and Review of the Literature. ( 29114286 )
2017
24
A Case of Multifocal Eosinophilic Granuloma Involving Spine and Pelvis in a Young Adult: A Radiopathological Correlation. ( 29333031 )
2017
25
Eosinophilic granuloma of the mandible mimicking a periapical lesion. ( 30895086 )
2017
26
[Eosinophilic granuloma of the parietal bone of an adult patient with BRAF mutation]. ( 28791997 )
2017
27
Intralesional Injection of Interferon-α2b in Orbital Eosinophilic Granuloma. ( 25226096 )
2016
28
Eosinophilic granuloma of the sacrum treated with radiation therapy: a case report. ( 26386170 )
2016
29
Pandora's box: eosinophilic granuloma at the cerebellopontine angle-should we open it? ( 26661575 )
2016
30
Eosinophilic granuloma of the lumbar spine in a child. ( 26723260 )
2016
31
Facial involutive tumors: A case of tumor-like eosinophilic granuloma of the skin. ( 26728823 )
2016
32
Eosinophilic granuloma with Splendore-Hoeppli material caused by Mannheimia granulomatis in a calf. ( 26947171 )
2016
33
Eosinophilic Granuloma of the Mandible: Is a Conservative Treatment Sufficient for Local Disease Control? ( 26999697 )
2016
34
Short Segment Stabilization by Protecting the Alar Ligaments in a Case of Eosinophilic Granuloma Involving the C2 Spine. ( 27032524 )
2016
35
Spontaneous resolution of an eosinophilic granuloma of the mandible following open biopsy. ( 27033671 )
2016
36
Emperipolesis in eosinophilic granuloma of the skull. ( 27191911 )
2016
37
Spontaneous remission of eosinophilic granuloma of the maxilla after incisional biopsy: a case report. ( 27251410 )
2016
38
A Novel Surgical Approach to Coracoid-based Eosinophilic Granuloma and the Technical Trick. ( 27280752 )
2016
39
Canine eosinophilic granuloma of the digits treated with prednisolone and chlorambucil. ( 27374751 )
2016
40
MEDICAL MANAGEMENT OF RECURRENT EOSINOPHILIC GRANULOMA IN TWO BLACK RHINOCEROS (DICEROS BICORNIS). ( 27691969 )
2016
41
Eosinophilic Granuloma Presenting as Palatal Swelling. ( 27891486 )
2016
42
The surgical strategy for eosinophilic granuloma of the pediatric cervical spine complicated with neurologic deficit and/or spinal instability. ( 27923375 )
2016
43
Eosinophilic Granuloma in Jaw Bone: A Pare Pediatric Case Report. ( 28446855 )
2016
44
Eosinophilic granuloma of the skull base: patient with unique clinical moreover, radiographic presentation. ( 25597609 )
2015
45
Eosinophilic granuloma of mandibular condyle: resection and complete regeneration. ( 25729234 )
2015
46
Skull fracture mimicking eosinophilic granuloma. ( 25758644 )
2015
47
Adult onset asynchronous multifocal eosinophilic granuloma of bone: an 11-year follow-up. ( 25793108 )
2015
48
Healing calvarial eosinophilic granuloma or healing skull fracture? ( 25837576 )
2015
49
Solitary eosinophilic granuloma of mandibular condyle: literature review and report of a rare case. ( 25861187 )
2015
50
Solitary Hepatic Eosinophilic Granuloma Accompanied by Eosinophilia Without Parasitosis: Report of a Case. ( 26414822 )
2015

Variations for Eosinophilic Granuloma

Expression for Eosinophilic Granuloma

Search GEO for disease gene expression data for Eosinophilic Granuloma.

Pathways for Eosinophilic Granuloma

Pathways related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 BRAF CD1A CD36 EPX RNASE3
2 10.61 CD1A CD36

GO Terms for Eosinophilic Granuloma

Cellular components related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.92 CD36 DCN EPX RNASE3

Biological processes related to Eosinophilic Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 BRAF DCN
2 defense response to Gram-positive bacterium GO:0050830 8.96 CD36 RNASE3
3 neutrophil degranulation GO:0043312 8.8 CD36 EPX RNASE3

Sources for Eosinophilic Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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