MCID: ESN006
MIFTS: 37

Eosinophilic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Eosinophilic Meningitis

MalaCards integrated aliases for Eosinophilic Meningitis:

Name: Eosinophilic Meningitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10361
ICD9CM 35 322.1
SNOMED-CT 68 25671008
UMLS 73 C0154652

Summaries for Eosinophilic Meningitis

MalaCards based summary : Eosinophilic Meningitis is related to hypereosinophilic syndrome and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain and endothelial, and related phenotypes are hematopoietic system and immune system

Related Diseases for Eosinophilic Meningitis

Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 28.1 CCL11 IL13 IL4 IL5
2 angiostrongyliasis 27.2 CCL11 IL13 IL4 IL5 MMP9 PLAU
3 gnathomiasis 11.0
4 meningitis 10.8
5 cough variant asthma 10.6 IL4 IL5
6 chromoblastomycosis 10.6 IL4 MMP9
7 egg allergy 10.5 IL4 IL5
8 intrinsic asthma 10.5 IL4 IL5
9 atopic keratoconjunctivitis 10.5 IL4 IL5
10 pemphigoid gestationis 10.5 CCL11 IL5
11 non-suppurative otitis media 10.5 IL4 IL5
12 cercarial dermatitis 10.5 IL4 IL5
13 toxic oil syndrome 10.5 IL4 IL5
14 primary amebic meningoencephalitis 10.5 IL4 IL5
15 blepharoconjunctivitis 10.5 CCL11 IL4
16 papillary conjunctivitis 10.5 CCL11 IL4
17 eosinophilic gastroenteritis 10.5 CCL11 IL5
18 chronic eosinophilic pneumonia 10.4 CCL11 IL5
19 giant papillary conjunctivitis 10.4 CCL11 IL4
20 allergic bronchopulmonary aspergillosis 10.4 IL4 IL5
21 milk allergy 10.4 IL4 IL5
22 immunoglobulin a deficiency 1 10.4 CD40LG IL4
23 congenital hypogammaglobulinemia 10.4 CD40LG IL4
24 parasitic ichthyosporea infectious disease 10.4 CD40LG IL4
25 periodontosis 10.4 CD40LG MMP9
26 rhinosporidiosis 10.4 CD40LG IL4
27 intratubular embryonal carcinoma 10.3 MMP9 PLAU
28 immunodeficiency with hyper-igm, type 1 10.3 CD40LG IL4
29 japanese spotted fever 10.3 CCL11 CD40LG
30 buruli ulcer 10.3 CD40LG IL4
31 pustulosis palmaris et plantaris 10.3 CD40LG IL5
32 norwegian scabies 10.3 CD40LG IL5
33 primary systemic mycosis 10.3 CD40LG IL4
34 paracoccidioidomycosis 10.3 IL4 IL5
35 coccidiosis 10.3 CD40LG IL4
36 pelvic inflammatory disease 10.3 CD40LG MMP9
37 lichen disease 10.3 CD40LG IL4
38 cryptosporidiosis 10.2 CCL11 CD40LG
39 churg-strauss syndrome 10.2 CD40LG IL5
40 scleritis 10.2 IL4 IL5 MMP9
41 granulomatous hepatitis 10.2 CD40LG IL4
42 carrion's disease 10.2 CCL11 CD40LG
43 extrinsic cardiomyopathy 10.2 CD40LG IL4
44 opportunistic mycosis 10.2 CD40LG IL4
45 echinococcosis 10.1 CD40LG IL5
46 vernal conjunctivitis 10.1 CD40LG IL4
47 blepharitis 10.1 CCL11 IL4 MMP9
48 cytokine deficiency 10.1 IL13 IL5
49 allergic contact dermatitis 10.1 IL4 IL5
50 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL13 IL5

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to Eosinophilic Meningitis

Symptoms & Phenotypes for Eosinophilic Meningitis

MGI Mouse Phenotypes related to Eosinophilic Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CCL11 CD40LG IL13 IL4 IL5 MMP9
2 immune system MP:0005387 9.8 CCL11 CD40LG IL13 IL4 IL5 MMP9
3 digestive/alimentary MP:0005381 9.77 IL13 IL4 IL5 MMP9 PLAU
4 integument MP:0010771 9.55 CD40LG IL13 IL4 MMP9 PLAU
5 reproductive system MP:0005389 9.43 CD40LG IL13 IL4 IL5 MMP9 PLAU
6 respiratory system MP:0005388 9.1 CCL11 IL13 IL4 IL5 MMP9 PLAU

Drugs & Therapeutics for Eosinophilic Meningitis

Drugs for Eosinophilic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882

Search NIH Clinical Center for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

Anatomical Context for Eosinophilic Meningitis

MalaCards organs/tissues related to Eosinophilic Meningitis:

41
Brain, Endothelial

Publications for Eosinophilic Meningitis

Articles related to Eosinophilic Meningitis:

(show top 50) (show all 229)
# Title Authors Year
1
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
2
Invasive Pomacea snails as important intermediate hosts of Angiostrongylus cantonensis in Laos, Cambodia and Vietnam: Implications for outbreaks of eosinophilic meningitis. ( 29574000 )
2018
3
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an infant: A case report. ( 29901586 )
2018
4
Chronic eosinophilic meningitis as a manifestation of isolated spinal neurocysticercosis: A rare case and a review of literature. ( 29547198 )
2018
5
Angiostrongylus cantonensis DNA in Cerebrospinal Fluid of Persons with Eosinophilic Meningitis, Laos. ( 29148389 )
2017
6
Eosinophilic Meningitis Caused by Angiostrongylus cantonensis. ( 28704038 )
2017
7
Angiostrongylus cantonensis Is an Important Cause of Eosinophilic Meningitis in Southern Vietnam. ( 28158507 )
2017
8
Eosinophilic Meningitis Due to Infection With Paragonimus kellicotti. ( 28158416 )
2017
9
Closing the Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947512 )
2017
10
Autochthonous Case of Eosinophilic Meningitis Caused by Angiostrongylus cantonensis, France, 2016. ( 28518042 )
2017
11
Angiostrongylus cantonensis Eosinophilic Meningitis in an Infant, Tennessee, USA. ( 28930003 )
2017
12
The Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947508 )
2017
13
An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000. ( 27350332 )
2016
14
Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. ( 27278827 )
2016
15
Eosinophilic meningitis triggered by implanted Gliadel wafers: case report. ( 27285546 )
2016
16
Eosinophilic meningitis caused by Angiostrongylus cantonensis mimicking embolic stroke. ( 27185606 )
2016
17
Dexamethasone inhibits brain apoptosis in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 25890054 )
2015
18
Real-Time Polymerase Chain Reaction Detection of Angiostrongylus cantonensis DNA in Cerebrospinal Fluid from Patients with Eosinophilic Meningitis. ( 26526920 )
2015
19
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis. ( 26682840 )
2015
20
Corticosteroids for parasitic eosinophilic meningitis. ( 25687750 )
2015
21
Evaluation of dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of eosinophilic meningitis due to Angio-strongylus cantonensis (Nematoda: Metastrongyloidea). ( 25801261 )
2015
22
Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. ( 25660199 )
2015
23
Eosinophilic meningitis: a case series and review of literature of Angiostrongylus cantonensis and Gnathostoma spinigerum. ( 25560024 )
2015
24
Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. ( 25910624 )
2015
25
Angiostrongylus cantonensis eosinophilic meningitis: a clinical study of 42 consecutive cases in French Polynesia. ( 24583335 )
2014
26
Eosinophilic Meningitis After Bovine Dural Graft Placement in a 5-Year-Old Male. ( 24803627 )
2014
27
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
28
A rare case of Ibuprofen-induced eosinophilic meningitis in a 13-year-old girl. ( 24596473 )
2014
29
Expect the unexpected: a case of isolated eosinophilic meningitis in toxocariasis. ( 25535488 )
2014
30
14-3-3I^ protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24555778 )
2014
31
Eosinophilic meningitis due to Angiostrongylus cantonensis with confirmed finding of intrathecal parasite. ( 24676451 )
2014
32
MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model. ( 24682888 )
2014
33
Eosinophilic meningitis caused by Angiostrongylus cantonensis - a neglected disease with escalating importance. ( 25776582 )
2014
34
Unusual Larva in the CSF and Unique MRI Findings in a Case of Eosinophilic Meningitis. ( 25806134 )
2014
35
Eosinophilic meningitis: what's the "diff"? ( 24060328 )
2014
36
Eosinophilic meningitis caused by Angiostrongylus cantonensis: an emergent disease in Brazil. ( 25075779 )
2014
37
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
38
Eosinophilic meningitis. ( 23829911 )
2013
39
Molecular diagnosis of eosinophilic meningitis due to Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) by polymerase chain reaction-DNA sequencing of cerebrospinal fluids of patients. ( 23440126 )
2013
40
First case of neurognathostomiasis in Taiwan-A Thai laborer presenting with eosinophilic meningitis and intracranial hemorrhage. ( 23969044 )
2013
41
Eosinophilic meningitis in a previously healthy 13-year-old child. ( 23328824 )
2013
42
Eosinophilic meningitis caused by primary angiitis of the central nervous system. ( 23774554 )
2013
43
Medical management of eosinophilic meningitis following bovine graft duraplasty for Chiari malformation Type I repair: case report. ( 23909615 )
2013
44
An 8-week Brain MRI Follow-up Analysis of Rat Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. ( 24207053 )
2013
45
An interesting case of eosinophilic meningitis. ( 23730662 )
2013
46
Eosinophilic meningitis in a 10-year old nigerian boy: a case report. ( 24381722 )
2013
47
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. ( 23445744 )
2013
48
Dexamethasone downregulated the expression of CSF 14-3-3I^ protein in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24361722 )
2013
49
Genetic diversity of the rat lungworm, Angiostrongylus cantonensis, the major cause of eosinophilic meningitis. ( 23901375 )
2013
50
Clinical aspects of eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis, the rat lungworm. ( 23901382 )
2013

Variations for Eosinophilic Meningitis

Expression for Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for Eosinophilic Meningitis

Pathways related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 CCL11 CD40LG IL13 IL4 IL5 MMP9
2
Show member pathways
13.15 CCL11 CD40LG IL13 IL4 IL5 YWHAB
3
Show member pathways
13.04 CCL11 CD40LG IL13 IL4 IL5
4
Show member pathways
12.98 CCL11 CD40LG IL13 IL4 IL5 MMP9
5
Show member pathways
12.65 CCL11 CD40LG IL13 IL4 IL5
6 12.61 IL13 IL4 IL5 MMP9
7
Show member pathways
12.4 IL13 IL4 IL5
8
Show member pathways
12.36 IL13 IL4 IL5
9
Show member pathways
12.22 IL13 IL5 YWHAB
10
Show member pathways
12.21 IL13 IL4 IL5
11
Show member pathways
12.2 CD40LG IL4 IL5
12
Show member pathways
11.89 CCL11 IL13 IL4 IL5 MMP9
13
Show member pathways
11.88 CCL11 IL13 IL4 IL5
14 11.73 CCL11 IL13 IL4 MMP9
15 11.65 IL13 IL4 IL5
16 11.63 IL13 IL4 IL5
17
Show member pathways
11.59 CD40LG IL4 IL5
18 11.36 CCL11 CD40LG IL4 IL5
19 11.34 IL13 IL4
20 11.32 MMP9 PLAU
21 11.31 MMP9 PLAU
22
Show member pathways
11.28 MMP9 PLAU
23 11.17 CD40LG IL4 IL5
24 11.14 MMP9 PLAU
25 11.14 IL13 IL4 IL5
26 11.1 CD40LG MMP9
27 11.09 IL13 IL4 IL5
28 11.07 CD40LG IL4
29 11 IL13 IL4 IL5
30 10.92 CCL11 IL13 IL4 IL5
31 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU

GO Terms for Eosinophilic Meningitis

Cellular components related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 CD40LG IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 CD40LG IL13 IL4 IL5 MMP9

Biological processes related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CCL11 CD40LG IL13 IL5
2 positive regulation of cell migration GO:0030335 9.58 CCL11 MMP9 PLAU
3 immune response GO:0006955 9.55 CCL11 CD40LG IL13 IL4 IL5
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.43 IL13 IL4
5 positive regulation of B cell proliferation GO:0030890 9.43 IL13 IL4 IL5
6 cytokine-mediated signaling pathway GO:0019221 9.35 CCL11 IL13 IL4 IL5 MMP9
7 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
8 regulation of signaling receptor activity GO:0010469 9.1 CCL11 CD40LG IL13 IL4 IL5 PLAU

Molecular functions related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 CD40LG IL13 IL4 IL5
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4

Sources for Eosinophilic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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