MCID: ESN006
MIFTS: 36

Eosinophilic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Eosinophilic Meningitis

MalaCards integrated aliases for Eosinophilic Meningitis:

Name: Eosinophilic Meningitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10361
ICD9CM 34 322.1
NCIt 50 C128374
SNOMED-CT 67 25671008
UMLS 70 C0154652

Summaries for Eosinophilic Meningitis

MalaCards based summary : Eosinophilic Meningitis is related to meningitis and cytokine deficiency. An important gene associated with Eosinophilic Meningitis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include brain, lung and skin, and related phenotypes are hematopoietic system and immune system

Related Diseases for Eosinophilic Meningitis

Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 396)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.0 MMP9 IL5 IL4 IL2 IL13 IL10
2 cytokine deficiency 30.4 IL5 IL13
3 cysticercosis 30.2 IL5 IL4 IL10 IGHE
4 myelitis 30.0 MMP9 IL10 CCL11
5 angiostrongyliasis 29.8 PLAU MMP9 IL5 IL4 IL2 IL13
6 paragonimiasis 29.8 IL5 IL13 IGHE
7 sarcoidosis 1 29.8 IL2 IL13 CCL11
8 nervous system disease 29.8 MMP9 IL4 IL2 IL10
9 chronic meningitis 29.7 YWHAB MMP9 IL5 IL13 CCL11
10 toxocariasis 29.6 IL5 IL4 IL13 IL10 IGHE
11 hypereosinophilic syndrome 29.6 IL5 IL4 IL2 IL13 IL10 IGHE
12 toxoplasmosis 29.4 IL5 IL4 IL10 CD40LG
13 gastroenteritis 29.4 MMP9 IL5 IL4 IL10 CCL11
14 intestinal schistosomiasis 29.4 IL5 IL4 IL2 IL13 IL10
15 diarrhea 28.9 IL5 IL2 IL13 IL10 CD40LG
16 schistosomiasis 28.5 IL5 IL4 IL2 IL13 IL10 IGHE
17 autoimmune disease 28.5 MMP9 IL5 IL4 IL2 IL13 IL10
18 allergic disease 28.3 IL5 IL4 IL2 IL13 IL10 IGHE
19 gnathomiasis 11.1
20 meningoencephalitis 10.5
21 headache 10.4
22 1-chloro-2,4-dinitrobenzene allergic contact dermatitis 10.3 IL4 IL2
23 acute asthma 10.3 IL5 IL4
24 virus associated hemophagocytic syndrome 10.3 IL4 IL2
25 jak3-deficient severe combined immunodeficiency 10.3 IL4 IL2
26 cefaclor allergy 10.3 IL5 IL13
27 cefuroxime allergy 10.3 IL5 IL13
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
29 respiratory syncytial virus infectious disease 10.3 IL5 IL13
30 loeffler syndrome 10.3 IL5 IL13
31 paresthesia 10.3
32 orange allergy 10.3 IL5 IL13
33 patulous eustachian tube 10.3 IL5 CCL11
34 neurodermatitis 10.3 IL4 IL13
35 intratubular embryonal carcinoma 10.3 PLAU MMP9
36 pemphigoid gestationis 10.3 IL5 CCL11
37 chromoblastomycosis 10.2 MMP9 IL4
38 ocular motor apraxia 10.2
39 hydrocephalus 10.2
40 scleritis 10.2 MMP9 IL5 IL4
41 tropical endomyocardial fibrosis 10.2 IL4 IL10
42 perforated corneal ulcer 10.2 PLAU MMP9
43 acute transverse myelitis 10.2 MMP9 IL10
44 gnathostoma infection 10.2
45 erythema multiforme 10.2 IL5 IL4 IL2
46 eosinophilic gastroenteritis 10.2 IL5 IL4 CCL11
47 folliculitis 10.2 IL5 IL4 CCL11
48 acute gonococcal cervicitis 10.2 IL4 IL10
49 autoimmune vasculitis 10.2 IL4 IL2
50 aztreonam allergy 10.2 IL5 IL2 IL13

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to Eosinophilic Meningitis

Symptoms & Phenotypes for Eosinophilic Meningitis

MGI Mouse Phenotypes related to Eosinophilic Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CCL11 CCL24 CD40LG HGF IL10 IL13
2 immune system MP:0005387 9.96 CCL11 CCL24 CD40LG IL10 IL13 IL2
3 digestive/alimentary MP:0005381 9.91 IL10 IL13 IL2 IL4 IL5 MMP9
4 liver/biliary system MP:0005370 9.63 HGF IL10 IL2 IL4 IL5 PLAU
5 reproductive system MP:0005389 9.56 CD40LG IL10 IL13 IL2 IL4 IL5
6 respiratory system MP:0005388 9.28 CCL11 CCL24 IL10 IL13 IL2 IL4

Drugs & Therapeutics for Eosinophilic Meningitis

Search Clinical Trials , NIH Clinical Center for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

Anatomical Context for Eosinophilic Meningitis

MalaCards organs/tissues related to Eosinophilic Meningitis:

40
Brain, Lung, Skin, Spinal Cord, Thymus, Liver, Nk Cells

Publications for Eosinophilic Meningitis

Articles related to Eosinophilic Meningitis:

(show top 50) (show all 533)
# Title Authors PMID Year
1
Tetraventricular Hydrocephalus Following Eosinophilic Meningitis due to Angiostrongylus cantonensis in a 14-Month-Old Boy From Mayotte: A Case Report. 61
33728356 2021
2
TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection. 61
33683530 2021
3
In vitro efficacy of anthelmintics on Angiostrongylus cantonensis L3 larvae. 61
32799943 2021
4
Eosinophilic Meningitis in a Toddler. 61
33632958 2021
5
Dexamethasone downregulates the expressions of MMP-9 and oxidative stress in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. 61
33004090 2021
6
Variation in Angiostrongylus cantonensis infection in definitive and intermediate hosts in Hawaii, a global hotspot of rat lungworm disease. 61
32907654 2021
7
An unusual cause of visual loss: Subfoveal, motile angiostrongyliasis. 61
33470180 2021
8
An integrative study of the invasive jumping-snail Ovachlamys fulgens (Gastropoda, Helicarionidae) in Rio de Janeiro and its fast spreading in Southeastern and Southern Brazil. 61
33656047 2021
9
MicroRNA miR-155-5p knockdown attenuates Angiostrongylus cantonensis-induced eosinophilic meningitis by downregulating MMP9 and TSLP proteins. 61
32966836 2021
10
Downregulated RPS-30 in Angiostrongylus cantonensis L5 plays a defensive role against damage due to oxidative stress. 61
33298148 2020
11
Clinical features and course of Angiostrongylus cantonensis eosinophilic meningitis in patients receiving supportive therapy. 61
33294648 2020
12
Biomphalaria glabrata infected with Angiostrongylus cantonensis: Proteomic changes in the snail host. 61
32931750 2020
13
Meningitis patients with Angiostrongylus cantonensis may present without eosinophilia in the cerebrospinal fluid in northern Vietnam. 61
33351806 2020
14
Case Report: Protracted Eosinophilic Meningitis due to Probable Angiostrongyliasis. 61
33236700 2020
15
AcanR3990 qPCR: a novel, highly sensitive, bioinformatically-informed assay to detect Angiostrongylus cantonensis infections. 61
33252651 2020
16
Case of eosinophilic meningitis in an autistic child. 61
32896664 2020
17
Angiostrongylus cantonensis infection induces MMP-9 and causes tight junction protein disruption associated with Purkinje cell degeneration. 61
32789733 2020
18
First record of natural infection by Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) in Belocaulus willibaldoi and Rattus norvegicus in an urban area of São Paulo city, SP, Brazil. 61
33083611 2020
19
Eosinophilic meningitis outbreak related to religious practice. 61
32553843 2020
20
A case of human angiostrongyliasis manifesting as eosinophilic meningitis in Okinawa, Japan. 61
32305672 2020
21
Angiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report. 61
32502661 2020
22
Temporal-spatial expressions of interleukin-4, interleukin-10, and interleukin-13 in the brains of C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis: An immunohistochemical study. 61
30600200 2020
23
Case Report: Angiostrongylus cantonensis Meningoencephalitis in a 9-Month-Old Baby in Vietnam. 61
32431278 2020
24
Angiostrongyliasis infection masquerading as granulomatosis with polyangiitis: a case-based review. 61
32424614 2020
25
The excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis induces autophagy via the Sonic hedgehog pathway in mouse brain astrocytes. 61
32479527 2020
26
Species Identity and Size are Associated with Rat Lungworm Infection in Gastropods. 61
32676832 2020
27
Molecular cloning and characterization of a cathepsin L-like cysteine protease of Angiostrongylus cantonensis. 61
31756482 2020
28
Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes. 61
32552877 2020
29
First case report of eosinophilic meningitis associated with cerebral toxoplasmosis in an HIV-positive patient. 61
32264778 2020
30
Physiology and immunity of the invasive giant African snail, Achatina (Lissachatina) fulica, intermediate host of Angiostrongylus cantonensis. 61
31877327 2020
31
Eosinophilic meningitis due to Angiostrongylus cantonensis in Europe. 61
31972289 2020
32
Case Report: Subarachnoid Hemorrhage and Eosinophilic Meningitis due to Disseminated Fascioliasis. 61
31933459 2020
33
A Case Report of Slug Ingestion Causing Eosinophilic Meningitis, Papilledema, and Pronounced Motor Weakness in a US Marine. 61
31436288 2020
34
Development of an immunochromatographic device to detect antibodies for rapid diagnosis of human angiostrongyliasis. 61
31690362 2020
35
Control of eosinopilic meningitis caused by Angiostrongylus cantonensis in China. 61
32563328 2020
36
SCHISTOSOMAL MYELORADICULOPATHY IN A NON-ENDEMIC AREA. 61
31939512 2020
37
First cases of Angiostrongylus cantonensis infection reported in Martinique, 2002-2017. 61
32394891 2020
38
Two cases of neuroangiostrongyliasis: A rare disease because rarely considered or rarely diagnosed? 61
30945367 2019
39
The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome. 61
31751335 2019
40
IL-17A neutralizing antibody attenuates eosinophilic meningitis caused by Angiostrongylus cantonensis by involving IL-17RA/Traf6/NF-κB signaling. 61
31415761 2019
41
An ecological study of eosinophilic meningitis caused by the nematode, Angiostrongylus cantonensis (Chen, 1935) (Nematoda: Metastrongylidae). 61
31220635 2019
42
First record of Bulimulus tenuissimus (Mollusca) as potential experimental intermediate host of Angiostrongylus cantonensis (Nematoda). 61
30379205 2019
43
Application of Recombinant Angiostrongylus cantonensis Galectin-2 Protein for Serodiagnosis of Human Angiostrongyliasis by Immunoblotting. 61
31392957 2019
44
Validation of a death assay for Angiostrongylus cantonensis larvae (L3) using propidium iodide in a rat model (Rattus norvegicus). 61
31267883 2019
45
Histopathological characterization of Toxocara canis- and T. cati-induced neurotoxocarosis in the mouse model. 61
31350619 2019
46
Angiostrongylus cantonensis in North African hedgehogs as vertebrate hosts, Mallorca, Spain, October 2018. 61
31431209 2019
47
Magnetic resonance imaging findings and clinical manifestations in cerebral angiostrongyliasis from Dali, China. 61
31313505 2019
48
Diagnostic importance of eosinophilic meningitis in HIV-positive and HIV-negative patients. 61
30673998 2019
49
Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection. 61
31284347 2019
50
Frequency of Occurrence of the Rat Lungworm Parasite in the Invasive Island Apple Snail in South Carolina, USA. 61
30719754 2019

Variations for Eosinophilic Meningitis

Expression for Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for Eosinophilic Meningitis

Pathways related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 YWHAB PLAU MMP9 IL5 IL4 IL2
2
Show member pathways
13.74 IL5 IL4 IL2 IL13 IL10 HGF
3
Show member pathways
13.61 IL5 IL4 IL2 IL13 IL10 HGF
4
Show member pathways
13.47 IL5 IL4 IL2 IL13 IL10 HGF
5
Show member pathways
13.3 YWHAB IL5 IL4 IL2 IL13 IL10
6
Show member pathways
13.22 IL5 IL4 IL2 IL13 IL10 HGF
7
Show member pathways
13.11 YWHAB MMP9 IL5 IL4 IL2 IL13
8 12.81 MMP9 IL5 IL4 IL2 IL13 HGF
9
Show member pathways
12.81 IL5 IL4 IL2 IL13 IL10 CD40LG
10
Show member pathways
12.6 IL4 IL2 IL10 IGHE CD40LG
11
Show member pathways
12.58 IL5 IL4 IL2 IL10 CD40LG
12
Show member pathways
12.57 IL5 IL4 IL2 IL13 IL10
13
Show member pathways
12.51 IL5 IL4 IL13 IGHE
14 12.49 IL4 IL2 IL10 CD40LG
15
Show member pathways
12.4 YWHAB IL5 IL2 IL13
16
Show member pathways
12.39 IL5 IL4 IL2 IL13 IL10
17
Show member pathways
12.35 YWHAB IL4 IGHE CCL11
18
Show member pathways
12.31 MMP9 IL5 IL4 IL13 CCL11
19
Show member pathways
12.3 IL2 IL10 CCL24 CCL11
20
Show member pathways
12.23 IL5 IL4 IL2 IL13 IL10 HGF
21 12.08 YWHAB IL13 IL10
22 11.99 IL5 IL4 IL2 IL10
23
Show member pathways
11.95 IL5 IL2 IL13
24 11.94 MMP9 IL4 IL2
25 11.81 IL5 IL4 IL2 IL13
26 11.78 IL5 IL4 IL2 IL13 IL10
27
Show member pathways
11.77 IL5 IL4 IL2 CD40LG
28 11.69 IL5 IL4 IL10 CD40LG
29
Show member pathways
11.64 MMP9 IL2 CD40LG
30 11.6 IL5 IL4 IL10 IGHE CD40LG CCL11
31 11.56 MMP9 IL4 IL13 IL10 IGHE HGF
32 11.53 IL10 HGF CD40LG
33 11.52 IL4 IL13 IL10
34 11.5 PLAU MMP9 HGF
35 11.36 IL5 IL4 IL2 CD40LG
36 11.32 IL5 IL4 IL13
37 11.3 IL5 IL4 IL2 IL13 IL10 CCL11
38 11.29 IL5 IL4 IL2 IL13 IL10
39 11.22 IL5 IL4 IL2 IL13 IL10
40 10.97 PLAU MMP9 IL5 IL4 IL13 HGF
41 10.92 MMP9 HGF
42 10.92 IL5 IL4 IL2 IL13 IL10 HGF
43 10.81 IL5 IL4 IL13

GO Terms for Eosinophilic Meningitis

Cellular components related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 PLAU MMP9 IL5 IL4 IL2 IL13
2 extracellular region GO:0005576 9.4 PLAU MMP9 IL5 IL4 IL2 IL13

Biological processes related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.17 PLAU IL5 IL4 IL10 CD40LG CCL24
2 negative regulation of apoptotic process GO:0043066 9.91 MMP9 IL4 IL2 IL10 HGF CD40LG
3 MAPK cascade GO:0000165 9.88 YWHAB IL5 IL2 HGF
4 inflammatory response GO:0006954 9.88 IL5 IL13 CD40LG CCL24 CCL11
5 chemotaxis GO:0006935 9.83 PLAU CCL24 CCL11
6 positive regulation of angiogenesis GO:0045766 9.82 HGF CCL24 CCL11
7 negative regulation of inflammatory response GO:0050728 9.8 IL4 IL2 IL13 IL10 HGF
8 B cell differentiation GO:0030183 9.75 IL4 IL10 CD40LG
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.74 IL4 IL2 IL13
10 positive regulation of endothelial cell proliferation GO:0001938 9.73 IL10 CCL24 CCL11
11 positive regulation of cell migration GO:0030335 9.73 PLAU MMP9 IL4 HGF CCL24 CCL11
12 positive regulation of T cell proliferation GO:0042102 9.72 IL4 IL2 CD40LG
13 positive regulation of B cell proliferation GO:0030890 9.67 IL5 IL4 IL2 IL13
14 positive regulation of T cell differentiation GO:0045582 9.64 IL4 IL2
15 positive regulation of macrophage activation GO:0043032 9.64 IL13 IL10
16 eosinophil chemotaxis GO:0048245 9.63 CCL24 CCL11
17 cellular response to hepatocyte growth factor stimulus GO:0035729 9.63 IL10 HGF
18 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 IL4 IL13 IL10
19 macrophage activation GO:0042116 9.62 IL4 IL13
20 positive regulation of interleukin-10 production GO:0032733 9.62 IL4 IL13 HGF CD40LG
21 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IL4 IL10
22 negative regulation of T-helper 17 cell differentiation GO:2000320 9.61 IL4 IL2
23 immune response GO:0006955 9.61 IL5 IL4 IL2 IL13 IL10 IGHE
24 positive regulation of isotype switching to IgG isotypes GO:0048304 9.6 IL4 IL2
25 positive regulation of mast cell degranulation GO:0043306 9.59 IL4 IL13
26 type 2 immune response GO:0042092 9.54 IL4 IL10
27 negative regulation of complement-dependent cytotoxicity GO:1903660 9.52 IL4 IL13
28 positive regulation of plasma cell differentiation GO:1900100 9.51 IL2 IL10
29 regulation of isotype switching GO:0045191 9.49 IL4 IL10
30 positive regulation of immunoglobulin production GO:0002639 9.46 IL5 IL2 IL13 IL10
31 cytokine-mediated signaling pathway GO:0019221 9.28 MMP9 IL5 IL4 IL2 IL13 IL10

Molecular functions related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.35 IL5 IL4 IL2 IL10 HGF
2 cytokine activity GO:0005125 9.23 IL5 IL4 IL2 IL13 IL10 CD40LG
3 CCR3 chemokine receptor binding GO:0031728 9.16 CCL24 CCL11

Sources for Eosinophilic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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