MCID: ESN006
MIFTS: 40

Eosinophilic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Eosinophilic Meningitis

MalaCards integrated aliases for Eosinophilic Meningitis:

Name: Eosinophilic Meningitis 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10361
ICD9CM 36 322.1
NCIt 51 C128374
SNOMED-CT 69 25671008
UMLS 74 C0154652

Summaries for Eosinophilic Meningitis

MalaCards based summary : Eosinophilic Meningitis is related to hypereosinophilic syndrome and angiostrongyliasis. An important gene associated with Eosinophilic Meningitis is YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and endothelial, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Eosinophilic Meningitis

Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 29.1 CCL11 IL13 IL4 IL5
2 angiostrongyliasis 28.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
3 gnathomiasis 11.2
4 meningitis 10.9
5 chromoblastomycosis 10.3 IL4 MMP9
6 cough variant asthma 10.3 IL4 IL5
7 egg allergy 10.3 IL4 IL5
8 sulfamethoxazole allergy 10.3 IL4 IL5
9 atopic keratoconjunctivitis 10.3 IL4 IL5
10 intrinsic asthma 10.3 IL4 IL5
11 trichinosis 10.3 IL4 IL5
12 non-suppurative otitis media 10.3 IL4 IL5
13 toxic oil syndrome 10.3 IL4 IL5
14 acute transverse myelitis 10.2 IL10 MMP9
15 transverse myelitis 10.2 IL10 MMP9
16 allergic bronchopulmonary aspergillosis 10.2 IL4 IL5
17 cephalosporin allergy 10.2 IL10 IL5
18 pemphigoid gestationis 10.2 CCL11 IL5
19 necatoriasis 10.2 IL10 IL5
20 blepharitis 10.2 CCL11 MMP9
21 cow milk allergy 10.2 IL10 IL5
22 tropical endomyocardial fibrosis 10.2 IL10 IL4
23 endomyocardial fibrosis 10.2 IL10 IL4
24 hyperlucent lung 10.2 IL10 IL4
25 tungiasis 10.2 IL10 IL4
26 blepharoconjunctivitis 10.2 CCL11 IL4
27 eosinophilic gastroenteritis 10.2 CCL11 IL5
28 retinitis pigmentosa 22 10.2 IL10 IL4
29 baylisascariasis 10.2 IL10 IL4
30 mycetoma 10.2 IL10 MMP9
31 multicentric castleman disease 10.2 IL10 IL5
32 chronic eosinophilic pneumonia 10.2 CCL11 IL5
33 papillary conjunctivitis 10.2 CCL11 IL4
34 yellow fever 10.2 IL4 IL5
35 giant papillary conjunctivitis 10.2 CCL11 IL4
36 autoimmune gastritis 10.2 IL10 IL4
37 orofacial granulomatosis 10.2 IL10 IL4
38 buruli ulcer 10.2 IL10 IL4
39 churg-strauss syndrome 10.2 IL10 IL5
40 bardet-biedl syndrome 15 10.2 IL10 IL4
41 primary systemic mycosis 10.2 IL10 IL4
42 poliomyelitis 10.2 IL10 IL4
43 eales disease 10.2 IL10 IL4
44 coccidiosis 10.1 IL10 IL4
45 genital herpes 10.1 IL10 IL4
46 transient hypogammaglobulinemia of infancy 10.1 IL10 IL4
47 vulvovaginitis 10.1 CCL11 IL10
48 q fever 10.1 IL10 IL4
49 scabies 10.1 CCL11 IL10
50 aphthous stomatitis 10.1 IL10 IL4

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to Eosinophilic Meningitis

Symptoms & Phenotypes for Eosinophilic Meningitis

MGI Mouse Phenotypes related to Eosinophilic Meningitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CCL11 IL10 IL13 IL4 IL5 MMP9
2 digestive/alimentary MP:0005381 9.85 IL10 IL13 IL4 IL5 MMP9 PLAU
3 immune system MP:0005387 9.8 CCL11 IL10 IL13 IL4 IL5 MMP9
4 integument MP:0010771 9.55 IL10 IL13 IL4 MMP9 PLAU
5 reproductive system MP:0005389 9.43 IL10 IL13 IL4 IL5 MMP9 PLAU
6 respiratory system MP:0005388 9.17 CCL11 IL10 IL13 IL4 IL5 MMP9

Drugs & Therapeutics for Eosinophilic Meningitis

Drugs for Eosinophilic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882

Search NIH Clinical Center for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

Anatomical Context for Eosinophilic Meningitis

MalaCards organs/tissues related to Eosinophilic Meningitis:

42
Lung, Brain, Endothelial, Skin, Bone, Heart, Bone Marrow

Publications for Eosinophilic Meningitis

Articles related to Eosinophilic Meningitis:

(show top 50) (show all 240)
# Title Authors Year
1
A blind passenger: a rare case of documented seroconversion in an Angiostrongylus cantonensis induced eosinophilic meningitis in a traveler visiting friends and relatives. ( 31016026 )
2019
2
Increased 14-3-3β and γ protein isoform expressions in parasitic eosinophilic meningitis caused by Angiostrongylus cantonensis infection in mice. ( 30845271 )
2019
3
Eosinophilic Meningitis: Report of Three Cases from a Hilly Area in Kerala. ( 30692771 )
2019
4
Diagnostic importance of eosinophilic meningitis in HIV-positive and HIV-negative patients. ( 30673998 )
2019
5
Pharmacological Management of Severe Neuropathic Pain in a Case of Eosinophilic Meningitis Related to Angiostrongylus cantonensis. ( 30416830 )
2018
6
Eosinophilic meningitis caused by consumption of meat of monitor lizard (Varanus bengalensis). ( 30038112 )
2018
7
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an infant: A case report. ( 29901586 )
2018
8
Invasive Pomacea snails as important intermediate hosts of Angiostrongylus cantonensis in Laos, Cambodia and Vietnam: Implications for outbreaks of eosinophilic meningitis. ( 29574000 )
2018
9
Chronic eosinophilic meningitis as a manifestation of isolated spinal neurocysticercosis: A rare case and a review of literature. ( 29547198 )
2018
10
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
11
Angiostrongylus cantonensis DNA in Cerebrospinal Fluid of Persons with Eosinophilic Meningitis, Laos. ( 29148389 )
2017
12
Closing the Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947512 )
2017
13
The Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947508 )
2017
14
Angiostrongylus cantonensis Eosinophilic Meningitis in an Infant, Tennessee, USA. ( 28930003 )
2017
15
Eosinophilic Meningitis Caused by Angiostrongylus cantonensis. ( 28704038 )
2017
16
Autochthonous Case of Eosinophilic Meningitis Caused by Angiostrongylus cantonensis, France, 2016. ( 28518042 )
2017
17
Angiostrongylus cantonensis Is an Important Cause of Eosinophilic Meningitis in Southern Vietnam. ( 28158507 )
2017
18
Eosinophilic Meningitis Due to Infection With Paragonimus kellicotti. ( 28158416 )
2017
19
Eosinophilic meningitis triggered by implanted Gliadel wafers: case report. ( 27285546 )
2017
20
An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000. ( 27350332 )
2016
21
Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. ( 27278827 )
2016
22
Eosinophilic meningitis caused by Angiostrongylus cantonensis mimicking embolic stroke. ( 27185606 )
2016
23
Real-Time Polymerase Chain Reaction Detection of Angiostrongylus cantonensis DNA in Cerebrospinal Fluid from Patients with Eosinophilic Meningitis. ( 26526920 )
2016
24
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis. ( 26682840 )
2015
25
Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. ( 25910624 )
2015
26
Dexamethasone inhibits brain apoptosis in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 25890054 )
2015
27
Evaluation of dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of eosinophilic meningitis due to Angio-strongylus cantonensis (Nematoda: Metastrongyloidea). ( 25801261 )
2015
28
Corticosteroids for parasitic eosinophilic meningitis. ( 25687750 )
2015
29
Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. ( 25660199 )
2015
30
Eosinophilic meningitis: a case series and review of literature of Angiostrongylus cantonensis and Gnathostoma spinigerum. ( 25560024 )
2015
31
Eosinophilic meningitis after bovine dural graft placement in a 5-year-old male. ( 24803627 )
2015
32
First case of neurognathostomiasis in Taiwan--A Thai laborer presenting with eosinophilic meningitis and intracranial hemorrhage. ( 23969044 )
2015
33
Unusual Larva in the CSF and Unique MRI Findings in a Case of Eosinophilic Meningitis. ( 25806134 )
2014
34
Eosinophilic meningitis caused by Angiostrongylus cantonensis--a neglected disease with escalating importance. ( 25776582 )
2014
35
Expect the unexpected: a case of isolated eosinophilic meningitis in toxocariasis. ( 25535488 )
2014
36
Eosinophilic meningitis caused by Angiostrongylus cantonensis: an emergent disease in Brazil. ( 25075779 )
2014
37
MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model. ( 24682888 )
2014
38
Eosinophilic meningitis due to Angiostrongylus cantonensis with confirmed finding of intrathecal parasite. ( 24676451 )
2014
39
A rare case of Ibuprofen-induced eosinophilic meningitis in a 13-year-old girl. ( 24596473 )
2014
40
Angiostrongylus cantonensis eosinophilic meningitis: a clinical study of 42 consecutive cases in French Polynesia. ( 24583335 )
2014
41
14-3-3β protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24555778 )
2014
42
Dexamethasone downregulated the expression of CSF 14-3-3β protein in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24361722 )
2014
43
An 8-week brain MRI follow-up analysis of rat eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24207053 )
2014
44
Severe eosinophilic meningitis owing to Angiostrongylus cantonensis in young Jamaican children: case report and literature review. ( 24199629 )
2014
45
Eosinophilic meningitis: what's the "diff"? ( 24060328 )
2014
46
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
47
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
48
Clinical manifestations of Eosinophilic meningitis due to infection with Angiostrongylus cantonensis in children. ( 24516281 )
2013
49
Eosinophilic meningitis in a 10-year old nigerian boy: a case report. ( 24381722 )
2013
50
A severe case of Angiostrongylus eosinophilic meningitis with encephalitis and neurologic sequelae in Hawa'i. ( 23901383 )
2013

Variations for Eosinophilic Meningitis

Expression for Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for Eosinophilic Meningitis

Pathways related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 IL10 IL13 IL4 IL5 MMP9
2
Show member pathways
13.29 CCL11 IL10 IL13 IL4 IL5
3
Show member pathways
13.2 CCL11 IL10 IL13 IL4 IL5 YWHAB
4
Show member pathways
13.13 CCL11 IL10 IL13 IL4 IL5 MMP9
5
Show member pathways
13.09 CCL11 IL10 IL13 IL4 IL5
6
Show member pathways
12.7 CCL11 IL10 IL13 IL4 IL5
7 12.65 IL13 IL4 IL5 MMP9
8
Show member pathways
12.44 IL10 IL13 IL4 IL5
9
Show member pathways
12.38 IL13 IL4 IL5
10
Show member pathways
12.36 IL10 IL4 IL5
11
Show member pathways
12.25 IL13 IL5 YWHAB
12
Show member pathways
12.25 IL10 IL13 IL4 IL5
13
Show member pathways
12.2 CCL11 IL4 YWHAB
14
Show member pathways
12.16 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
12.11 IL10 IL13 IL4 IL5
16 12.02 IL10 IL13 YWHAB
17
Show member pathways
11.92 CCL11 IL10 IL13 IL4 IL5
18
Show member pathways
11.89 IL13 IL4 MMP9
19 11.85 IL10 IL4 IL5
20 11.78 CCL11 IL10 IL13 IL4 MMP9
21 11.7 IL10 IL13 IL4 IL5
22 11.68 IL13 IL4 IL5
23 11.56 CCL11 IL10 IL4 IL5
24 11.42 IL10 IL13 IL4
25 11.4 CCL11 IL10 IL13 IL4 MMP9
26 11.35 MMP9 PLAU
27 11.34 MMP9 PLAU
28
Show member pathways
11.32 MMP9 PLAU
29 11.21 IL13 IL4 IL5
30 11.18 MMP9 PLAU
31 11.16 IL4 IL5
32 11.13 IL10 IL13 IL4 IL5
33 11.03 CCL11 IL10 IL13 IL4 IL5
34 11.02 CCL11 IL10 IL13 IL4 IL5
35 10.97 IL10 IL13 IL4 IL5
36 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
37 10.84 CCL11 IL10 IL13 IL4 IL5

GO Terms for Eosinophilic Meningitis

Cellular components related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 IL10 IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 IL10 IL13 IL4 IL5 MMP9

Biological processes related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 CCL11 IL10 IL13 IL5
2 positive regulation of cell migration GO:0030335 9.69 CCL11 MMP9 PLAU
3 immune response GO:0006955 9.65 CCL11 IL10 IL13 IL4 IL5
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 IL10 MMP9
5 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
6 positive regulation of macrophage activation GO:0043032 9.49 IL10 IL13
7 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IL10 IL4
8 regulation of isotype switching GO:0045191 9.43 IL10 IL4
9 regulation of signaling receptor activity GO:0010469 9.43 CCL11 IL10 IL13 IL4 IL5 PLAU
10 type 2 immune response GO:0042092 9.4 IL10 IL4
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.33 IL10 IL13 IL4
13 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 IL10 IL13 IL4 IL5 MMP9

Molecular functions related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL13 IL4
2 growth factor activity GO:0008083 9.13 IL10 IL4 IL5
3 cytokine activity GO:0005125 9.02 CCL11 IL10 IL13 IL4 IL5

Sources for Eosinophilic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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