MCID: ESN006
MIFTS: 40

Eosinophilic Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Eosinophilic Meningitis

MalaCards integrated aliases for Eosinophilic Meningitis:

Name: Eosinophilic Meningitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10361
ICD9CM 35 322.1
NCIt 50 C128374
SNOMED-CT 68 25671008
UMLS 73 C0154652

Summaries for Eosinophilic Meningitis

MalaCards based summary : Eosinophilic Meningitis is related to angiostrongyliasis and hypereosinophilic syndrome. An important gene associated with Eosinophilic Meningitis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and endothelial, and related phenotypes are hematopoietic system and digestive/alimentary

Related Diseases for Eosinophilic Meningitis

Diseases related to Eosinophilic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
# Related Disease Score Top Affiliating Genes
1 angiostrongyliasis 29.5 PLAU MMP9 IL5 IL4 IL13 CCL11
2 hypereosinophilic syndrome 29.2 IL5 IL4 IL13 CCL11
3 gnathomiasis 11.1
4 meningitis 10.9
5 chromoblastomycosis 10.2 MMP9 IL4
6 cough variant asthma 10.2 IL5 IL4
7 egg allergy 10.2 IL5 IL4
8 atopic keratoconjunctivitis 10.2 IL5 IL4
9 sulfamethoxazole allergy 10.2 IL5 IL4
10 trichinosis 10.2 IL5 IL4
11 intrinsic asthma 10.2 IL5 IL4
12 pemphigoid gestationis 10.2 IL5 CCL11
13 non-suppurative otitis media 10.2 IL5 IL4
14 blepharitis 10.2 MMP9 CCL11
15 toxic oil syndrome 10.2 IL5 IL4
16 acute transverse myelitis 10.2 MMP9 IL10
17 eosinophilic gastroenteritis 10.2 IL5 CCL11
18 transverse myelitis 10.2 MMP9 IL10
19 blepharoconjunctivitis 10.2 IL4 CCL11
20 allergic bronchopulmonary aspergillosis 10.2 IL4 IL5
21 chronic eosinophilic pneumonia 10.2 IL5 CCL11
22 papillary conjunctivitis 10.1 IL4 CCL11
23 cephalosporin allergy 10.1 IL5 IL10
24 giant papillary conjunctivitis 10.1 IL4 CCL11
25 radiculopathy 10.1 CCL11 IL5
26 necatoriasis 10.1 IL5 IL10
27 cow milk allergy 10.1 IL5 IL10
28 tropical endomyocardial fibrosis 10.1 IL4 IL10
29 endomyocardial fibrosis 10.1 IL4 IL10
30 hyperlucent lung 10.1 IL4 IL10
31 tungiasis 10.1 IL4 IL10
32 multicentric castleman disease 10.1 IL5 IL10
33 castleman disease 10.1 IL10 IL5
34 mycetoma 10.1 IL10 MMP9
35 baylisascariasis 10.1 IL4 IL10
36 yellow fever 10.1 IL4 IL5
37 retinitis pigmentosa 22 10.1 IL4 IL10
38 scabies 10.1 IL10 CCL11
39 autoimmune gastritis 10.1 IL4 IL10
40 vulvovaginitis 10.1 IL10 CCL11
41 orofacial granulomatosis 10.1 IL4 IL10
42 bardet-biedl syndrome 15 10.1 IL10 IL4
43 buruli ulcer 10.1 IL4 IL10
44 churg-strauss syndrome 10.1 IL10 IL5
45 primary systemic mycosis 10.1 IL10 IL4
46 poliomyelitis 10.1 IL10 IL4
47 eales disease 10.1 IL10 IL4
48 coccidiosis 10.1 IL10 IL4
49 genital herpes 10.1 IL10 IL4
50 transient hypogammaglobulinemia of infancy 10.1 IL10 IL4

Graphical network of the top 20 diseases related to Eosinophilic Meningitis:



Diseases related to Eosinophilic Meningitis

Symptoms & Phenotypes for Eosinophilic Meningitis

MGI Mouse Phenotypes related to Eosinophilic Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.87 CCL11 IL10 IL13 IL4 IL5 MMP9
2 digestive/alimentary MP:0005381 9.85 IL10 IL13 IL4 IL5 MMP9 PLAU
3 immune system MP:0005387 9.8 CCL11 IL10 IL13 IL4 IL5 MMP9
4 integument MP:0010771 9.55 IL10 IL13 IL4 MMP9 PLAU
5 reproductive system MP:0005389 9.43 IL10 IL13 IL4 IL5 MMP9 PLAU
6 respiratory system MP:0005388 9.17 CCL11 IL10 IL13 IL4 IL5 MMP9

Drugs & Therapeutics for Eosinophilic Meningitis

Drugs for Eosinophilic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Research for Angiostrongylus Cantonensis and Costaricensis in French West Indies and French Guiana Recruiting NCT03378882

Search NIH Clinical Center for Eosinophilic Meningitis

Genetic Tests for Eosinophilic Meningitis

Anatomical Context for Eosinophilic Meningitis

MalaCards organs/tissues related to Eosinophilic Meningitis:

41
Brain, Bone, Endothelial, Lung, Skin, Heart, Bone Marrow

Publications for Eosinophilic Meningitis

Articles related to Eosinophilic Meningitis:

(show top 50) (show all 236)
# Title Authors Year
1
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an infant: A case report. ( 29901586 )
2018
2
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
3
Invasive Pomacea snails as important intermediate hosts of Angiostrongylus cantonensis in Laos, Cambodia and Vietnam: Implications for outbreaks of eosinophilic meningitis. ( 29574000 )
2018
4
Chronic eosinophilic meningitis as a manifestation of isolated spinal neurocysticercosis: A rare case and a review of literature. ( 29547198 )
2018
5
Eosinophilic meningitis caused by consumption of meat of monitor lizard (Varanus bengalensis). ( 30038112 )
2018
6
Pharmacological Management of Severe Neuropathic Pain in a Case of Eosinophilic Meningitis Related to Angiostrongylus cantonensis. ( 30416830 )
2018
7
Angiostrongylus cantonensis DNA in Cerebrospinal Fluid of Persons with Eosinophilic Meningitis, Laos. ( 29148389 )
2017
8
Closing the Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947512 )
2017
9
Autochthonous Case of Eosinophilic Meningitis Caused by Angiostrongylus cantonensis, France, 2016. ( 28518042 )
2017
10
The Brief Case: Angiostrongylus cantonensis Eosinophilic Meningitis in a Returned Traveler. ( 28947508 )
2017
11
Eosinophilic Meningitis Due to Infection With Paragonimus kellicotti. ( 28158416 )
2017
12
Eosinophilic Meningitis Caused by Angiostrongylus cantonensis. ( 28704038 )
2017
13
Angiostrongylus cantonensis Is an Important Cause of Eosinophilic Meningitis in Southern Vietnam. ( 28158507 )
2017
14
Angiostrongylus cantonensis Eosinophilic Meningitis in an Infant, Tennessee, USA. ( 28930003 )
2017
15
Comparative pathogenesis of eosinophilic meningitis caused by Angiostrongylus mackerrasae and Angiostrongylus cantonensis in murine and guinea pig models of human infection. ( 27278827 )
2016
16
Eosinophilic meningitis triggered by implanted Gliadel wafers: case report. ( 27285546 )
2016
17
Eosinophilic meningitis caused by Angiostrongylus cantonensis mimicking embolic stroke. ( 27185606 )
2016
18
An epidemiological study of A. cantonensis in Jamaica subsequent to an outbreak of human cases of eosinophilic meningitis in 2000. ( 27350332 )
2016
19
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis. ( 26682840 )
2015
20
Evaluation of dot immunogold filtration assay (DIGFA) for rapid serodiagnosis of eosinophilic meningitis due to Angio-strongylus cantonensis (Nematoda: Metastrongyloidea). ( 25801261 )
2015
21
Eosinophilic meningitis: a case series and review of literature of Angiostrongylus cantonensis and Gnathostoma spinigerum. ( 25560024 )
2015
22
Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. ( 25660199 )
2015
23
Corticosteroids for parasitic eosinophilic meningitis. ( 25687750 )
2015
24
Real-Time Polymerase Chain Reaction Detection of Angiostrongylus cantonensis DNA in Cerebrospinal Fluid from Patients with Eosinophilic Meningitis. ( 26526920 )
2015
25
Dexamethasone inhibits brain apoptosis in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 25890054 )
2015
26
Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. ( 25910624 )
2015
27
Communicating hydrocephalus following eosinophilic meningitis is pathogenic for chronic Viliuisk encephalomyelitis in Northeastern Siberia. ( 24586232 )
2014
28
A rare case of Ibuprofen-induced eosinophilic meningitis in a 13-year-old girl. ( 24596473 )
2014
29
Expect the unexpected: a case of isolated eosinophilic meningitis in toxocariasis. ( 25535488 )
2014
30
Eosinophilic meningitis caused by Angiostrongylus cantonensis - a neglected disease with escalating importance. ( 25776582 )
2014
31
Eosinophilic meningitis caused by Angiostrongylus cantonensis: an emergent disease in Brazil. ( 25075779 )
2014
32
Acute eosinophilic meningitis and orbital inflammation from presumed angiostrongyliasis. ( 24862785 )
2014
33
Eosinophilic meningitis: what's the "diff"? ( 24060328 )
2014
34
Unusual Larva in the CSF and Unique MRI Findings in a Case of Eosinophilic Meningitis. ( 25806134 )
2014
35
MicroRNA expressions associated with eosinophilic meningitis caused by Angiostrongylus cantonensis infection in a mouse model. ( 24682888 )
2014
36
Eosinophilic meningitis due to Angiostrongylus cantonensis with confirmed finding of intrathecal parasite. ( 24676451 )
2014
37
14-3-3I^ protein expression in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. ( 24555778 )
2014
38
Eosinophilic Meningitis After Bovine Dural Graft Placement in a 5-Year-Old Male. ( 24803627 )
2014
39
Angiostrongylus cantonensis eosinophilic meningitis: a clinical study of 42 consecutive cases in French Polynesia. ( 24583335 )
2014
40
Eosinophilic meningitis. ( 23829911 )
2013
41
Molecular diagnosis of eosinophilic meningitis due to Angiostrongylus cantonensis (Nematoda: Metastrongyloidea) by polymerase chain reaction-DNA sequencing of cerebrospinal fluids of patients. ( 23440126 )
2013
42
Medical management of eosinophilic meningitis following bovine graft duraplasty for Chiari malformation Type I repair: case report. ( 23909615 )
2013
43
Eosinophilic meningitis caused by Angiostrongylus cantonensis in an adolescent with mental retardation and pica disorder. ( 23445744 )
2013
44
Severe eosinophilic meningitis owing to Angiostrongylus cantonensis in young Jamaican children: case report and literature review. ( 24199629 )
2013
45
A severe case of Angiostrongylus eosinophilic meningitis with encephalitis and neurologic sequelae in Hawa'i. ( 23901383 )
2013
46
Eosinophilic meningitis secondary to intravenous vancomycin. ( 22842500 )
2013
47
The first case of Angiostrongylus cantonensis eosinophilic meningitis diagnosed in the city of SALo Paulo, Brazil. ( 23563769 )
2013
48
Guest Editor's message: Eosinophilic meningitis caused by Angiostrongylus cantonensis, the rat lungworm: biology, distribution, epidemiology, detection, diagnosis, treatment, and management. ( 23901370 )
2013
49
Clinical aspects of eosinophilic meningitis and meningoencephalitis caused by Angiostrongylus cantonensis, the rat lungworm. ( 23901382 )
2013
50
Genetic diversity of the rat lungworm, Angiostrongylus cantonensis, the major cause of eosinophilic meningitis. ( 23901375 )
2013

Variations for Eosinophilic Meningitis

Expression for Eosinophilic Meningitis

Search GEO for disease gene expression data for Eosinophilic Meningitis.

Pathways for Eosinophilic Meningitis

Pathways related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 IL10 IL13 IL4 IL5 MMP9
2
Show member pathways
13.29 CCL11 IL10 IL13 IL4 IL5
3
Show member pathways
13.2 CCL11 IL10 IL13 IL4 IL5 YWHAB
4
Show member pathways
13.13 CCL11 IL10 IL13 IL4 IL5 MMP9
5
Show member pathways
13.09 CCL11 IL10 IL13 IL4 IL5
6
Show member pathways
12.7 CCL11 IL10 IL13 IL4 IL5
7 12.65 IL13 IL4 IL5 MMP9
8
Show member pathways
12.44 IL10 IL13 IL4 IL5
9
Show member pathways
12.38 IL13 IL4 IL5
10
Show member pathways
12.25 IL13 IL5 YWHAB
11
Show member pathways
12.25 IL10 IL13 IL4 IL5
12
Show member pathways
12.24 IL10 IL4 IL5
13
Show member pathways
12.2 CCL11 IL4 YWHAB
14
Show member pathways
12.16 CCL11 IL13 IL4 IL5 MMP9
15
Show member pathways
12.11 IL10 IL13 IL4 IL5
16 12.02 IL10 IL13 YWHAB
17
Show member pathways
11.92 CCL11 IL10 IL13 IL4 IL5
18
Show member pathways
11.89 IL13 IL4 MMP9
19 11.85 IL10 IL4 IL5
20 11.78 CCL11 IL10 IL13 IL4 MMP9
21 11.7 IL10 IL13 IL4 IL5
22 11.68 IL13 IL4 IL5
23 11.56 CCL11 IL10 IL4 IL5
24 11.42 IL10 IL13 IL4
25 11.4 CCL11 IL10 IL13 IL4 MMP9
26 11.35 MMP9 PLAU
27 11.34 MMP9 PLAU
28
Show member pathways
11.32 MMP9 PLAU
29 11.21 IL13 IL4 IL5
30 11.18 MMP9 PLAU
31 11.16 IL4 IL5
32 11.13 IL10 IL13 IL4 IL5
33 11.03 CCL11 IL10 IL13 IL4 IL5
34 11.02 CCL11 IL10 IL13 IL4 IL5
35 10.97 IL10 IL13 IL4 IL5
36 10.9 CCL11 IL13 IL4 IL5 MMP9 PLAU
37 10.84 CCL11 IL10 IL13 IL4 IL5

GO Terms for Eosinophilic Meningitis

Cellular components related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CCL11 IL10 IL13 IL4 IL5 MMP9
2 extracellular space GO:0005615 9.17 CCL11 IL10 IL13 IL4 IL5 MMP9

Biological processes related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 CCL11 IL10 IL13 IL5
2 positive regulation of cell migration GO:0030335 9.69 CCL11 MMP9 PLAU
3 immune response GO:0006955 9.65 CCL11 IL10 IL13 IL4 IL5
4 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.52 IL10 MMP9
5 positive regulation of B cell proliferation GO:0030890 9.5 IL13 IL4 IL5
6 positive regulation of macrophage activation GO:0043032 9.49 IL10 IL13
7 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IL10 IL4
8 regulation of isotype switching GO:0045191 9.43 IL10 IL4
9 regulation of signaling receptor activity GO:0010469 9.43 CCL11 IL10 IL13 IL4 IL5 PLAU
10 type 2 immune response GO:0042092 9.4 IL10 IL4
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.33 IL10 IL13 IL4
13 cytokine-mediated signaling pathway GO:0019221 9.1 CCL11 IL10 IL13 IL4 IL5 MMP9

Molecular functions related to Eosinophilic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 9.16 IL13 IL4
2 growth factor activity GO:0008083 9.13 IL10 IL4 IL5
3 cytokine activity GO:0005125 9.02 CCL11 IL10 IL13 IL4 IL5

Sources for Eosinophilic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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