MCID: EPD015
MIFTS: 43

Epidemic Typhus

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Epidemic Typhus

MalaCards integrated aliases for Epidemic Typhus:

Name: Epidemic Typhus 12 53 59 3 15
Typhus 12 76 53 55 15 73
Endemic Flea-Borne Typhus 12 73
Brill-Zinsser Disease 53 73
Murine Typhus 12 53
Jail Fever 12 53
Epidemic Louse-Borne Typhus Fever Due to Rickettsia Prowazekii 12
Typhus Group Rickettsial Disease 73
Louse-Borne [epidemic] Typhus 12
Typhus, Epidemic Louse-Borne 73
Epidemic Louse-Borne Typhus 12
Typhus, Endemic Flea-Borne 44
Exanthematic Typhus Fever 12
Louse-Borne Rickettsiosis 12
Flea-Borne Rickettsiosis 12
Murine [endemic] Typhus 12
Typhus Exanthematique 12
Endemic Typhus Fever 12
Exanthematous Typhus 12
Louse-Borne Typhus 12
Epidemic Typhus 12
Flea-Borne Typhus 12
Classical Typhus 12
Sylvatic Typhus 12
European Typhus 12
Petechial Fever 12
Rat Flea Typhus 12
Relapsing Fever 73
Endemic Typhus 53
Hospital Fever 12
Mexican Typhus 12
Moscow Typhus 12
Urban Typhus 12
Famine Fever 12
Prison Fever 12
Typhus Fever 12
Shop Typhus 12
Flea Typhus 12
Ship Fever 12

Characteristics:

Orphanet epidemiological data:

59
epidemic typhus
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050480 DOID:11256
ICD9CM 35 080 081.0 081.9
Orphanet 59 ORPHA83314
MESH via Orphanet 45 D014438
UMLS via Orphanet 74 C0041473
ICD10 via Orphanet 34 A75.0

Summaries for Epidemic Typhus

Disease Ontology : 12 A typhus that has material basis in Rickettsia prowazekii, which is transmitted by human body louse (Pediculus humanus corporis). The infection has symptom high fever, has symptom cough, has symptom rash, has symptom severe muscle pain, has symptom chills, has symptom falling blood pressure, has symptom stupor, has symptom sensitivity to light, and has symptom delirium.

MalaCards based summary : Epidemic Typhus, also known as typhus, is related to brill-zinsser disease and scrub typhus, and has symptoms including recurrent fevers An important gene associated with Epidemic Typhus is AFF2 (AF4/FMR2 Family Member 2), and among its related pathways/superpathways is Selenium Metabolism and Selenoproteins. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes and bone.

CDC : 3 Typhus fevers are a group of diseases caused by bacteria that are spread to humans by fleas, lice, and chiggers. Typhus fevers include scrub typhus, murine typhus, and epidemic typhus. Chiggers spread scrub typhus, fleas spread murine typhus, and body lice spread epidemic typhus. The most common symptoms are fever, headaches, and sometimes rash.

Wikipedia : 76 Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus,... more...

Related Diseases for Epidemic Typhus

Diseases related to Epidemic Typhus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 brill-zinsser disease 33.6 AFF2 CD40LG
2 scrub typhus 32.0 CD40LG GPT TCN2
3 rocky mountain spotted fever 30.4 AFF2 CD40LG MRRF
4 spotted fever 30.4 AFF2 CCL5
5 relapsing epidemic typhus 12.2
6 endemic typhus 11.3
7 pediculus humanus corporis infestation 11.1
8 flinders island spotted fever 10.7 AFF2 CD40LG
9 ornithosis 10.7 AFF2 CD40LG
10 fasciolopsiasis 10.7 CD40LG TCN2
11 japanese spotted fever 10.7 AFF2 CD40LG
12 toxocariasis 10.6 CD40LG TCN2
13 hepatitis d 10.4 CD40LG GPT
14 hemorrhagic fever 10.3 CD40LG GPT
15 hepatitis e 10.3 CD40LG GPT
16 african tick-bite fever 10.3 CCL5 CD40LG
17 inclusion conjunctivitis 10.2 CCL5 CD40LG
18 hepatitis a 10.2 CD40LG GPT
19 meningoencephalitis 10.1 CCL5 CD40LG
20 idiopathic neutropenia 10.1 CCL5 CD40LG
21 dengue disease 10.1 CCL5 CD40LG
22 trench fever 10.1
23 chikungunya 10.1 CCL5 CD40LG
24 human immunodeficiency virus infectious disease 10.0 CCL5 CD40LG
25 norwegian scabies 10.0 CD40LG NKX2-1
26 severe acute respiratory syndrome 9.9 CCL5 CD40LG
27 relapsing fever 9.9
28 parasitic protozoa infectious disease 9.9 CD40LG TCN2
29 temporal arteritis 9.9 CCL5 CD40LG
30 salmonellosis 9.8
31 pasteurellosis 9.8
32 pneumonia 9.8
33 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
34 q fever 9.8
35 dysentery 9.8
36 louse-borne relapsing fever 9.8
37 meningitis 9.8
38 encephalitis 9.8
39 transmitted_by 9.8
40 rabies 9.7 CCL5 CD40LG
41 viral infectious disease 9.7 CCL5 CD40LG GPT
42 congenital syphilis 9.5
43 trehalase deficiency 9.3 AFF2 CD40LG NKX2-1 TCN2

Graphical network of the top 20 diseases related to Epidemic Typhus:



Diseases related to Epidemic Typhus

Symptoms & Phenotypes for Epidemic Typhus

UMLS symptoms related to Epidemic Typhus:


recurrent fevers

Drugs & Therapeutics for Epidemic Typhus

Drugs for Epidemic Typhus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
4 Antibiotics, Antitubercular Phase 4,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
6 Antimalarials Phase 4,Phase 3,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
9 Antitubercular Agents Phase 4,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 5462516 0
11
Rifampicin Approved Not Applicable 13292-46-1 5458213 5381226
12
Ethanol Approved 64-17-5 702
13 Cytochrome P-450 CYP3A Inducers Not Applicable
14 Nucleic Acid Synthesis Inhibitors Not Applicable
15 Antibodies
16 Immunoglobulin A
17 Immunoglobulin G
18 Immunoglobulin M
19 Immunoglobulins
20 Vaccines

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 Not Applicable doxycycline;rifampin
4 Causes of Fever in Bangladeshi Patients Unknown status NCT02339259
5 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
6 Scrub Typhus RDT Study Recruiting NCT03269266
7 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
8 Scrub Typhus Pediatric Immunology Study Recruiting NCT02398162
9 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
10 The Impact of C-reactive Protein Testing Recruiting NCT02758821 Not Applicable
11 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Not yet recruiting NCT02876367
12 Eschar Investigations in Scrub Typhus Not yet recruiting NCT02915861

Search NIH Clinical Center for Epidemic Typhus

Cochrane evidence based reviews: typhus, endemic flea-borne

Genetic Tests for Epidemic Typhus

Anatomical Context for Epidemic Typhus

MalaCards organs/tissues related to Epidemic Typhus:

41
Testes, Bone

Publications for Epidemic Typhus

Articles related to Epidemic Typhus:

(show top 50) (show all 109)
# Title Authors Year
1
The epidemic typhus and trench fever are risk for public health due to increased migration in southeast of Turkey. ( 29126839 )
2018
2
Rickettsia Prowazekii (Epidemic Typhus) ( 28846313 )
2017
3
An Overview of Epidemic Typhus in the World and Iran during the 19th and 20th Centuries. ( 27743443 )
2016
4
A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012. ( 27352876 )
2016
5
The History of Epidemic Typhus. ( 27726780 )
2016
6
Drought and epidemic typhus, central Mexico, 1655-1918. ( 24564928 )
2014
7
Genome Sequencing of Four Strains of Rickettsia prowazekii, the Causative Agent of Epidemic Typhus, Including One Flying Squirrel Isolate. ( 23814035 )
2013
8
Environmental risk factors for epidemic typhus in the United States: wintertime is typhus time. ( 22533108 )
2012
9
Brill-Zinsser disease in a patient following infection with sylvatic epidemic typhus associated with flying squirrels. ( 20687836 )
2010
10
Cluster of sylvatic epidemic typhus cases associated with flying squirrels, 2004-2006. ( 19624912 )
2009
11
Epidemic typhus. ( 18582834 )
2008
12
A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. ( 17537665 )
2007
13
Autochthonous epidemic typhus associated with Bartonella quintana bacteremia in a homeless person. ( 15891141 )
2005
14
Multispacer typing of Rickettsia prowazekii enabling epidemiological studies of epidemic typhus. ( 16145131 )
2005
15
Reemerging threat of epidemic typhus in Algeria. ( 15297561 )
2004
16
The history of epidemic typhus. ( 15081509 )
2004
17
Epidemic typhus meningitis in the southwestern United States. ( 11247722 )
2001
18
Serological differentiation of murine typhus and epidemic typhus using cross-adsorption and Western blotting. ( 10882661 )
2000
19
Epidemic typhus imported from Algeria. ( 10511530 )
1999
20
Survey of three bacterial louse-associated diseases among rural Andean communities in Peru: prevalence of epidemic typhus, trench fever, and relapsing fever. ( 10476755 )
1999
21
Imported epidemic typhus. ( 9853468 )
1998
22
Outbreak of epidemic typhus in Russia. ( 9798622 )
1998
23
Outbreak of epidemic typhus associated with trench fever in Burundi. ( 9717922 )
1998
24
Epidemic typhus in a prison in Burundi. ( 9196749 )
1997
25
Jail fever (epidemic typhus) outbreak in Burundi. ( 9284381 )
1997
26
How Charles Nicolle of the Pasteur Institute discovered that epidemic typhus is transmitted by lice: reminiscences from my years at the Pasteur Institute in Paris. ( 8855211 )
1996
27
Epidemic typhus risk in Rwandan refugee camps. ( 7947074 )
1994
28
Epidemic typhus fever and hearing loss: a histological study (Hallpike collection of temporal bone sections). ( 8320509 )
1993
29
A clinico-epidemiological study of epidemic typhus in Africa. ( 1600020 )
1992
30
Cardiovascular and pulmonary complications of epidemic typhus. ( 2763350 )
1989
31
Decreased oxygen utilization in epidemic typhus infection: case report with sequential hemodynamic studies. ( 3177416 )
1988
32
Flying squirrels and their ectoparasites: disseminators of epidemic typhus. ( 15462918 )
1987
33
Rickettsial vaccines with emphasis on epidemic typhus. Initial report of an old vaccine trial. ( 3095934 )
1986
34
Flying squirrel-associated Rickettsia prowazekii (epidemic typhus rickettsiae) characterized by a specific DNA fragment produced by restriction endonuclease digestion. ( 3009528 )
1986
35
Epidemic typhus acquired in Wisconsin. ( 3976245 )
1985
36
Epidemic typhus--Georgia. ( 6436662 )
1984
37
Detection and characterization of mouse monoclonal antibodies to epidemic typhus rickettsiae. ( 6415092 )
1983
38
Murine and epidemic typhus rickettsiae: how close is their relationship? ( 6817526 )
1982
39
Epidemic typhus associated with flying squirrels--United States. ( 6817059 )
1982
40
Indigenous acquisition of epidemic typhus in the eastern United States. ( 6781073 )
1981
41
Epidemic typhus (Rickettsia prowazekii) in Massachusetts: evidence of infection. ( 6783902 )
1981
42
Suspected Rocky Mountain spotted fever in the winter--epidemic typhus? ( 7312012 )
1981
43
Epidemic typhus in the United States associated with flying squirrels. ( 6785459 )
1981
44
Epidemic typhus infection in cynomolgus monkeys (Macaca fascicularis). ( 7439974 )
1980
45
Epizootiology of epidemic typhus (Rickettsia prowazekii) in flying squirrels. ( 646026 )
1978
46
Prescription and devotion: the Reverend Doctor Donne and the learned Doctor Mayerne--two seventeenth-century records of epidemic typhus fever. ( 362088 )
1978
47
Serologic diagnosis of epidemic typhus fever. ( 403761 )
1977
48
A reference, inactivated, epidemic typhus vaccine: clinical trials in man. ( 820697 )
1976
49
John Donne's Devotions: an early record of epidemic typhus. ( 791999 )
1976
50
Epidemic typhus rickettsiae isolated from flying squirrels. ( 806809 )
1975

Variations for Epidemic Typhus

Expression for Epidemic Typhus

Search GEO for disease gene expression data for Epidemic Typhus.

Pathways for Epidemic Typhus

Pathways related to Epidemic Typhus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.29 SARS SARS2

GO Terms for Epidemic Typhus

Biological processes related to Epidemic Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brain development GO:0007420 9.5 AFF2 NKX2-1 POU3F3
2 tRNA aminoacylation for protein translation GO:0006418 9.26 SARS SARS2
3 leukocyte cell-cell adhesion GO:0007159 9.16 CCL5 CD40LG
4 selenocysteinyl-tRNA(Sec) biosynthetic process GO:0097056 8.96 SARS SARS2
5 seryl-tRNA aminoacylation GO:0006434 8.62 SARS SARS2

Molecular functions related to Epidemic Typhus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aminoacyl-tRNA ligase activity GO:0004812 8.96 SARS SARS2
2 serine-tRNA ligase activity GO:0004828 8.62 SARS SARS2

Sources for Epidemic Typhus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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